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Pesquisa : B01.650.940.800.575.912.250.859.625 [Categoria DeCS]
Referências encontradas : 225 [refinar]
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[PMID]:29110583
[Au] Autor:Omer FAA; Hashim NBM; Ibrahim MY; Dehghan F; Yahayu M; Karimian H; Salim LZA; Mohan S
[Ad] Endereço:1 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G /G cell-cycle arrest.
[So] Source:Tumour Biol;39(11):1010428317731451, 2017 Nov.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Xanthones are phytochemical compounds found in a number of fruits and vegetables. Characteristically, they are noted to be made of diverse properties based on their biological, biochemical, and pharmacological actions. Accordingly, the apoptosis mechanisms induced by beta-mangostin, a xanthone compound isolated from Cratoxylum arborescens in the human promyelocytic leukemia cell line (HL60) in vitro, were examined in this study. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was done to estimate the cytotoxicity effect of ß-mangostin on the HL60 cell line. Acridine orange/propidium iodide and Hoechst 33342 dyes and Annexin V tests were conducted to detect the apoptosis features. Caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for Bcl-2, Bax, caspase-3, and caspase-9 Hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. Cell-cycle analysis conducted revealed that ß-mangostin inhibited the growth of HL60 at 58 µM in 24 h. The administration of ß-mangostin with HL60 caused cell morphological changes related to apoptosis which increased the number of early and late apoptotic cells. The ß-mangostin-catalyzed apoptosis action through caspase-3, caspase-7, and caspase-9 activation overproduced reactive oxygen species which downregulated the expression of antiapoptotic genes Bcl-2 and HSP70. Conversely, the expression of the apoptotic genes Bax, caspase-3, and caspase-9 were upregulated. Meanwhile, at the protein level, ß-mangostin activated the formation of cleaved caspase-3 and caspase-9 and also upregulated the p53. ß-mangostin arrested the cell cycle at the G /G phase. Overall, the results for ß-mangostin showed an antiproliferative effect in HL60 via stopping the cell cycle at the G /G phase and prompted the intrinsic apoptosis pathway.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Proteínas de Choque Térmico HSP70/efeitos dos fármacos
Leucemia Promielocítica Aguda
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Clusiaceae
Regulação para Baixo
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células HL-60
Proteínas de Choque Térmico HSP70/biossíntese
Seres Humanos
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (HSP70 Heat-Shock Proteins); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317731451


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[PMID]:28771629
[Au] Autor:Torroba-Balmori P; Budde KB; Heer K; González-Martínez SC; Olsson S; Scotti-Saintagne C; Casalis M; Sonké B; Dick CW; Heuertz M
[Ad] Endereço:Department of Forest Ecology and Genetics, INIA Forest Research Centre, Madrid, Spain.
[Ti] Título:Altitudinal gradients, biogeographic history and microhabitat adaptation affect fine-scale spatial genetic structure in African and Neotropical populations of an ancient tropical tree species.
[So] Source:PLoS One;12(8):e0182515, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The analysis of fine-scale spatial genetic structure (FSGS) within populations can provide insights into eco-evolutionary processes. Restricted dispersal and locally occurring genetic drift are the primary causes for FSGS at equilibrium, as described in the isolation by distance (IBD) model. Beyond IBD expectations, spatial, environmental or historical factors can affect FSGS. We examined FSGS in seven African and Neotropical populations of the late-successional rain forest tree Symphonia globulifera L. f. (Clusiaceae) to discriminate the influence of drift-dispersal vs. landscape/ecological features and historical processes on FSGS. We used spatial principal component analysis and Bayesian clustering to assess spatial genetic heterogeneity at SSRs and examined its association with plastid DNA and habitat features. African populations (from Cameroon and São Tomé) displayed a stronger FSGS than Neotropical populations at both marker types (mean Sp = 0.025 vs. Sp = 0.008 at SSRs) and had a stronger spatial genetic heterogeneity. All three African populations occurred in pronounced altitudinal gradients, possibly restricting animal-mediated seed dispersal. Cyto-nuclear disequilibria in Cameroonian populations also suggested a legacy of biogeographic history to explain these genetic patterns. Conversely, Neotropical populations exhibited a weaker FSGS, which may reflect more efficient wide-ranging seed dispersal by Neotropical bats and other dispersers. The population from French Guiana displayed an association of plastid haplotypes with two morphotypes characterized by differential habitat preferences. Our results highlight the importance of the microenvironment for eco-evolutionary processes within persistent tropical tree populations.
[Mh] Termos MeSH primário: Aclimatação
Clusiaceae/crescimento & desenvolvimento
Clusiaceae/genética
[Mh] Termos MeSH secundário: África
Variação Genética
Análise de Componente Principal
Clima Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182515


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[PMID]:28716025
[Au] Autor:Omer FAA; Hashim NM; Ibrahim MY; Aldoubi AF; Hassandarvish P; Dehghan F; Nordin N; Karimian H; Salim LZA; Abdulla MA; Al-Jashamy K; Mohan S
[Ad] Endereço:Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. fatimaomer51@yahoo.com.
[Ti] Título:Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo.
[So] Source:BMC Complement Altern Med;17(1):366, 2017 Jul 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Beta-mangostin (BM) is a xanthone-type of natural compound isolated from Cratoxylum arborescens. This study aimed to examine the apoptosis mechanisms induced by BM in a murine monomyelocytic cell line (WEHI-3) in vitro and in vivo. METHODS: A WEHI-3 cell line was used to evaluate the cytotoxicity of BM by MTT. AO/PI and Hoechst 33342 dyes, Annexin V, multiparametric cytotoxicity 3 by high content screening (HCS); cell cycle tests were used to estimate the features of apoptosis and BM effects. Caspase 3 and 9 activities, ROS, western blot for Bcl2, and Bax were detected to study the mechanism of apoptosis. BALB/c mice injected with WEHI-3 cells were used to assess the apoptotic effect of BM in vivo. RESULTS: BM suppressed the growth of WEHI-3 cells at an IC value of 14 ± 3 µg/mL in 24 h. The ROS production was increased inside the cells in the treated doses. Both caspases (9 and 3) were activated in treating WEHI-3 cells at 24, 48 and 72 h. Different signs of apoptosis were detected, such as cell membrane blebbing, DNA segmentation and changes in the asymmetry of the cell membrane. Another action by which BM could inhibit WEHI-3 cells is to restrain the cell cycle at the G1/G0 phase. In the in vivo study, BM reduced the destructive effects of leukaemia on the spleen and liver by inducing apoptosis in leukaemic cells. CONCLUSION: BM exerts anti-leukaemic properties in vitro and in vivo.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose
Clusiaceae/química
Leucemia/tratamento farmacológico
Fitoterapia
Extratos Vegetais/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/uso terapêutico
Caspase 3/metabolismo
Caspase 9/metabolismo
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular
Fígado/efeitos dos fármacos
Fígado/patologia
Camundongos Endogâmicos BALB C
Extratos Vegetais/uso terapêutico
Espécies Reativas de Oxigênio/metabolismo
Baço/efeitos dos fármacos
Baço/patologia
Xantonas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Xanthones); 9749WEV0CA (xanthone); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1867-0


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[PMID]:28653908
[Au] Autor:Rodanant P; Boonnak N; Surarit R; Kuvatanasuchati J; Lertsooksawat W
[Ad] Endereço:Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Thailand.
[Ti] Título:Antibacterial, anti-inflammatory and anti-oxidatant activities of various isolated compounds from Cratoxylum species.
[So] Source:Pak J Pharm Sci;30(3):667-674, 2017 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to investigate the bioactivity of twenty-nine known isolated compounds from Cratoxylum species including three anthraquinones, four triterpenes, and twenty-two xanthones. All isolated compounds were subjected to antibacterial, anti-inflammatory and anti-oxidant activities. Cytotoxicity evaluations were performed by MTT assay. The anti-oxidatant activity was performed using DPPH assay. The anti-inflammatory activity was evaluated from the production of cytokines TNF-α and IL1-ß using ELISA assay. Human gingival fibroblasts and monocytes could tolerate both anthraquinones and triterpenes. All isolated anthraquinones showed moderate-to-high antibacterial efficacy while compound A3 also demonstrated moderate anti-inflammatory effect. None of the isolated triterpenes, except for T1, inhibited the expression of TNF-α. A number of isolated xanthones was toxic to HGFs and monocytes. Compound X5, X14 and a 1:1 mixture of X5 and X6 showed comparative anti-inflammatory activity to dexamethasone. Several triterpene and xanthone compounds also expressed antibacterial effect against P. gingivalis. Some isolated xanthones exerted anti-oxidant activity comparable to ascorbic acid. Accordingly, selected pure compounds from plants of Cratoxylum genus might be of benefit in developing medications that are important in treating periodontal diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Clusiaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28228111
[Au] Autor:Kemegne GA; Mkounga P; Essia Ngang JJ; Sado Kamdem SL; Nkengfack AE
[Ad] Endereço:Department of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
[Ti] Título:Antimicrobial structure activity relationship of five anthraquinones of emodine type isolated from Vismia laurentii.
[So] Source:BMC Microbiol;17(1):41, 2017 Feb 22.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antimicrobial activity of anthraquinone compounds of emodine type has been reported by many authors. These compounds are found in Vismia laurentii (Clusiaceae), a plant used in traditional pharmacopoeia for treatment of microbial infections among others affections. The continuous identification of new compounds has raised the problem of the relation between the structure and antimicrobial properties. RESULTS: The yeast growth kinetics parameters were not influenced by the pH variation as it was the case for the other tested bacteria. Fungicidal activities were noted for all molecules while only few of them had bactericidal activities, mostly on Gram positive bacteria. Mathematical model establishing a quantitative relationship between physicochemical properties of molecules and their fungicidal activities were obtained for Candida albicans and showed that physicochemical properties impacting on antifungal activity were polarizability, partition coefficient, molecular weight and hydrogen bond acceptor. CONCLUSIONS: This work demonstrated that the presence of a long aliphatic chain methoxy group substituted in position two of the emodine structure increased the antibacterial properties of the studied compounds. Moreover this antimicrobial property depends on the pH of the environment, and specifically on the polarizability and number of hydrogen bond acceptors of the compound.
[Mh] Termos MeSH primário: Antraquinonas/farmacologia
Anti-Infecciosos/farmacologia
Clusiaceae/química
Extratos Vegetais/farmacologia
Relação Estrutura-Atividade
[Mh] Termos MeSH secundário: Antraquinonas/química
Antibacterianos/química
Antibacterianos/farmacologia
Anti-Infecciosos/química
Antifúngicos/química
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Fenômenos Químicos
Fungos/efeitos dos fármacos
Fungos/crescimento & desenvolvimento
Bactérias Gram-Positivas/efeitos dos fármacos
Ligações de Hidrogênio
Concentração de Íons de Hidrogênio
Cinética
Testes de Sensibilidade Microbiana/métodos
Modelos Teóricos
Estrutura Molecular
Peso Molecular
Extratos Vegetais/química
Leveduras/efeitos dos fármacos
Leveduras/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-0954-1


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[PMID]:28041556
[Au] Autor:Akpanika GA; Winters A; Wilson T; Ayoola GA; Adepoju-Bello AA; Hauck B
[Ad] Endereço:Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Nigeria. Electronic address: gakpanika@yahoo.com.
[Ti] Título:Polyphenols from Allanblackia floribunda seeds: Identification, quantification and antioxidant activity.
[So] Source:Food Chem;222:35-42, 2017 May 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oil rich seeds of Allanblackia floribunda, a tree from tropical Africa, have traditionally been used in food preparation. Furthermore, the therapeutic properties of various parts of this tree have long been exploited in traditional medicine. As both food and pharmaceutical industries show growing interest in tropical tree crops, this study aimed to investigate whether A. floribunda seeds could also be used as a source of potentially bioactive compounds. The polyphenol profile revealed six predominant compounds which were identified by HPLC-PDA-ESI/MS as the biflavonoids morelloflavone, Gb-2a and volkensiflavone and their respective glucosides. A range of less abundant flavones, flavonols and flavan-3-ols was also detected. All six major compounds showed antioxidant activity, with the activity of morelloflavone, its glucoside and Gb-2a-glucoside comparable with that of ascorbic acid. The main compounds accounted for approximately 10% of dry weight, making the seeds used for oil production a rich source of biflavonoids as a by-product.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Clusiaceae/química
Polifenóis/análise
[Mh] Termos MeSH secundário: Biflavonoides/análise
Biflavonoides/farmacologia
Polifenóis/farmacologia
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biflavonoids); 0 (Polyphenols); 16851-21-1 (morelloflavone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:28033006
[Au] Autor:Yang XW; Yang J; Xu G
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
[Ti] Título:Skeleton Reassignment of Type C Polycyclic Polyprenylated Acylphloroglucinols.
[So] Source:J Nat Prod;80(1):108-113, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The previous assignment of the type C skeleton of polycyclic polyprenylated acylphloroglucinols (PPAPs) was controversial and proved to be incorrect in this study. The structures of the type C PPAPs (3-6) were revised to corresponding type A structures (3a-6a) via C NMR spectroscopic analysis and a quantum computational chemistry method. Therefore, only types A and B PPAPs are likely present in plants of the family Clusiaceae.
[Mh] Termos MeSH primário: Clusiaceae/química
Hypericum/química
Floroglucinol/química
Compostos Policíclicos/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Floroglucinol/análogos & derivados
Floroglucinol/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polycyclic Compounds); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00754


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[PMID]:27856302
[Au] Autor:Oliveira AH; de Oliveira GG; Carnevale Neto F; Portuondo DF; Batista-Duharte A; Carlos IZ
[Ad] Endereço:Faculdade de Ciências Farmacêuticas. Universidade Estadual Paulista Julio Mesquita Filho, UNESP, Rod. Araraquara-Jaú - Km 1 -s/n -CEP: 14800-903, Araraquara, SP, Brazil.
[Ti] Título:Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii.
[So] Source:J Ethnopharmacol;195:266-274, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Since the strategy associating immunomodulators with antifungal drugs seems to be promissory to improve the treatment efficacy in fungal infections, we aimed to investigate the antifungal activity of V. guianensis ethanolic extract of leaves (VGL) and bark (VGB) against Sporothrix schenckii ATCC 16345 and their antinflammatory activities. MATERIAL AND METHODS: The extracts were analyzed by HPLC-DAD-IT MS/MS for in situ identification of major compounds. Antifungal activity was evaluated in vitro (microdilution test) and in vivo using a murine model of S. schenckii infection. The production of TNF-α, IFN-γ, IL-4, IL-10 and IL-12 by measured by ELISA, as well as measured the production and inhibition of the NO after treatment with the plant extracts or itraconazole (ITR). RESULTS: Two O-glucosyl-flavonoids and 16 prenylated benzophenone derivatives already described for Vismia were detected. Both VGL and VGB showed significant antifungal activity either in in vitro assay of microdilution (MIC=3.9µg/mL) and in vivo model of infection with reduction of S. schenckii load in spleen. It was also observed a predominance of reduction in the production of NO and the proinflammatory cytokines evaluated except TNFα, but with stimulation of IL-10, as evidence of a potential anti-inflammatory effect associated. CONCLUSION: The results showed that both VGL and VGB have a significant antifungal against S. schenckii and an anti-inflammatory activity. These results can support the use of these extracts for alternative treatment of sporotrichosis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antifúngicos/farmacologia
Clusiaceae/química
Extratos Vegetais/farmacologia
Sporothrix/efeitos dos fármacos
Esporotricose/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Antifúngicos/isolamento & purificação
Células Cultivadas
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Etanol/química
Interferon gama/metabolismo
Interleucina-10/metabolismo
Interleucina-12/metabolismo
Interleucina-4/metabolismo
Itraconazol/farmacologia
Masculino
Camundongos Endogâmicos BALB C
Óxido Nítrico/metabolismo
Fitoterapia
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Solventes/química
Sporothrix/imunologia
Esporotricose/imunologia
Esporotricose/metabolismo
Esporotricose/microbiologia
Espectrometria de Massas em Tandem
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antifungal Agents); 0 (IL10 protein, mouse); 0 (Plant Extracts); 0 (Solvents); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 187348-17-0 (Interleukin-12); 207137-56-2 (Interleukin-4); 304NUG5GF4 (Itraconazole); 31C4KY9ESH (Nitric Oxide); 3K9958V90M (Ethanol); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:27765208
[Au] Autor:Uekane TM; Nicolotti L; Griglione A; Bizzo HR; Rubiolo P; Bicchi C; Rocha-Leão MH; Rezende CM
[Ad] Endereço:Instituto de Química, Pós Graduação em Ciência de Alimentos, Universidade Federal do Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Bloco A-6°-Lab 626A, CEP: 21941-909, Cidade Universitária, Rio de Janeiro, RJ, Brazil. Electronic address: thais.uekane@gmail.com.
[Ti] Título:Studies on the volatile fraction composition of three native Amazonian-Brazilian fruits: Murici (Byrsonima crassifolia L., Malpighiaceae), bacuri (Platonia insignis M., Clusiaceae), and sapodilla (Manilkara sapota L., Sapotaceae).
[So] Source:Food Chem;219:13-22, 2017 Mar 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The volatile fraction of murici, bacuri and sapodilla are here studied because of their increasing interest for consumers, abundance of production in Brazil, and the general demand for new flavors and aromas. Their volatile profiles were studied by two High Concentration Capacity Headspace techniques (HCC-HS), Headspace Solid Phase Microextraction (HS-SPME) and Headspace Sorptive Extraction (HSSE), in combination with GC-MS. Murici volatile fraction mainly contains esters (38%), carboxylic acids (19%), aldehydes (11%), alcohols (14%), others (13%) and sulfur compounds; bacuri is characterized by terpenes (41%), non-terpenic alcohols (24%), esters (15%), aldehydes (6%), and others (12%); sapodilla consists of esters (33%), alcohols (27%), terpenes (18%) and others (21%). The GC-MS component co-elution was overcome by GC×GC-qMS. The adoption of modern analysis technologies afforded to achieve a better knowledge of the volatile fraction composition of these fruit pulps by increasing substantially the number of compounds identified.
[Mh] Termos MeSH primário: Clusiaceae/química
Frutas/química
Malpighiaceae/química
Manilkara/química
Microextração em Fase Sólida/métodos
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Brasil
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27907087
[Au] Autor:Rouger C; Pagie S; Derbré S; Le Ray AM; Richomme P; Charreau B
[Ad] Endereço:Université d'Angers, Campus du végétal, SFR4207 QUASAV, EA921 SONAS, Beaucouzé, France.
[Ti] Título:Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells.
[So] Source:PLoS One;11(12):e0167361, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endothelial cells (ECs) are key players in inflammation and immune responses involved in numerous pathologies. Although attempts were experimentally undertaken to prevent and control EC activation, drug leads and probes still remain necessary. Natural products (NPs) from Clusiaceous and Calophyllaceous plants were previously reported as potential candidates to prevent endothelial dysfunction. The present study aimed to identify more precisely the molecular scaffolds that could limit EC activation. Here, 13 polyphenols belonging to 5 different chemical types of secondary metabolites (i.e., mammea coumarins, a biflavonoid, a pyranochromanone acid, a polyprenylated polycyclic acylphloroglucinol (PPAP) and two xanthones) were tested on resting and cytokine-activated EC cultures. Quantitative and qualitative changes in the expression of both adhesion molecules (VCAM-1, ICAM-1, E-selectin) and major histocompatibility complex (MHC) molecules have been used to measure their pharmaceutical potential. As a result, we identified 3 mammea coumarins that efficiently reduce (up to >90% at 10 µM) both basal and cytokine-regulated levels of MHC class I, class II, MICA and HLA-E on EC surface. They also prevented VCAM-1 induction upon inflammation. From a structural point of view, our results associate the loss of the free prenyl group substituting mammea coumarins with a reduced cellular cytotoxicity but also an abrogation of their anti-inflammatory potential and a reduction of their immunosuppressive effects. A PPAP, guttiferone J, also triggers a strong immunomodulation but restricted to HLA-E and MHC class II molecules. In conclusion, mammea coumarins with a free prenyl group and the PPAP guttiferone J emerge as NPs able to drastically decrease both VCAM-1 and a set of MHC molecules and to potentially reduce the immunogenicity of the endothelium.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Células Endoteliais/efeitos dos fármacos
Inflamação/tratamento farmacológico
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Apresentação do Antígeno/efeitos dos fármacos
Produtos Biológicos/química
Clusiaceae/química
Cumarínicos/farmacologia
Citocinas/biossíntese
Selectina E/biossíntese
Células Endoteliais/patologia
Antígenos de Histocompatibilidade Classe II/biossíntese
Seres Humanos
Inflamação/genética
Inflamação/patologia
Molécula 1 de Adesão Intercelular/biossíntese
Interferon gama/biossíntese
Polifenóis/química
Prenilação/efeitos dos fármacos
Fator de Necrose Tumoral alfa/biossíntese
Molécula 1 de Adesão de Célula Vascular/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Coumarins); 0 (Cytokines); 0 (E-Selectin); 0 (Histocompatibility Antigens Class II); 0 (Polyphenols); 0 (Tumor Necrosis Factor-alpha); 0 (Vascular Cell Adhesion Molecule-1); 126547-89-5 (Intercellular Adhesion Molecule-1); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167361



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