Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.625.249 [Categoria DeCS]
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  1 / 43 MEDLINE  
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[PMID]:27371561
[Au] Autor:Pincebourde S; Suppo C
[Ad] Endereço:*Institut de Recherche sur la Biologie de l'Insecte (IRBI, CNRS UMR 7261), Université François Rabelais, Faculté des Sciences et Techniques, Tours 37200, France Société Entomologique Antilles-Guyane (SEAG), 18 Lotissement Amaryllis, 97354 Rémire-Montjoly, Guyane Française, France.
[Ti] Título:The Vulnerability of Tropical Ectotherms to Warming Is Modulated by the Microclimatic Heterogeneity.
[So] Source:Integr Comp Biol;56(1):85-97, 2016 07.
[Is] ISSN:1557-7023
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Most tropical ectotherms live near their physiological limits for temperature. Substantial ecological effects of global change are predicted in the tropics despite the low amplitude of temperature change. These predictions assume that tropical ectotherms experience air temperature as measured by weather stations or predicted by global circulation models. The body temperature of ectotherms, however, can deviate from ambient air when the organism samples the mosaic of microclimates at fine scales. The thermal heterogeneity of tropical landscapes has been quantified only rarely in comparison to temperate habitats, limiting our ability to infer the vulnerability to warming of tropical ectotherms. Here, we used thermal imaging to quantify the heterogeneity in surface temperatures across spatial scales, from the micro- up to landscape scale, at the top of an Inselberg in French Guiana. We measured the thermal heterogeneity at the scale of Clusia nemorosa leaves, by categorizing leaves in full sun versus leaves in the shade to quantify the microclimatic variance available to phytophagous insects. Then, we measured the thermal heterogeneity at the scales of the single shrub and the landscape, for several sites differing in their orientation toward the sun to quantify the microclimatic heterogeneity available for larger ectotherms. All measurements were made three times per day over four consecutive days. There was a high level of thermal heterogeneity at all spatial scales. The thermal variance varied between scales, increasing from the within-leaf surface to the landscape scale. It also shifted across the day in different ways depending on the spatial scale. Then, using a set of published data, we compared the critical temperature (CTmax) of neo-tropical ectotherms and temperature distributions. The portion of space above the CTmax varied substantially depending on spatial scale and taxa. Insects were particularly at risk at the surface of leaves exposed to solar radiation but not on shaded leaves. By contrast, ants tolerated elevated surface temperatures and can survive almost anywhere in the habitat. We suggest that the fine scale mosaic of microclimates in the tropics modulates the vulnerability of ectotherms to warming. By moving just a few meters, or even a few centimeters, small tropical ectotherms can radically change their microclimatic temperature and escape overheating.
[Mh] Termos MeSH primário: Anfíbios/fisiologia
Mudança Climática
Temperatura Alta
Insetos/fisiologia
Microclima
Répteis/fisiologia
[Mh] Termos MeSH secundário: Animais
Formigas/fisiologia
Clusia/fisiologia
Guiana Francesa
Folhas de Planta/fisiologia
Temperatura Ambiente
Clima Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160703
[St] Status:MEDLINE
[do] DOI:10.1093/icb/icw014


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[PMID]:26691460
[Au] Autor:Costa LA; Gusmão LF
[Ad] Endereço:Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
[Ti] Título:Characterization saprobic fungi on leaf litter of two species of trees in the Atlantic Forest, Brazil.
[So] Source:Braz J Microbiol;46(4):1027-35, 2015 Oct-Dec.
[Is] ISSN:1678-4405
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:We investigated the composition and structure of fungal communities associated with leaf litter generated by Clusia nemorosa and Vismia guianensis that belong to phylogenetically-related botanical families and exist together in a remnant of the Atlantic Forest in Bahia, Brazil. Samplings were conducted during wet (June 2011) and dry (January 2013) seasons in Serra da Jibóia. The fungi were isolated using particle filtration and the 1,832 isolates represented 92 taxa. The wet season yielded the largest number of isolates (1,141) and taxa (76) compared with the dry season (641 isolates and 37 taxa). The richness and diversity of fungal species associated with C. nemorosa (64 taxa, Simpson=0.95)were higher compared with those of V.guianensis (59 taxa, Simpson =0.90). Analysis of similarity (ANOSIM) revealed significant variations in the composition and community structure of fungi isolated from the two plants as a function of seasons. In contrast, nonmetric multidimensional scaling (NMDS) analysis show that the seasonality was an important influence on the distribution of fungal species. However, the populations of the saprobic fungal communities were dynamic, and several factors may influence such communities in the Atlantic Forest.
[Mh] Termos MeSH primário: Clusia/microbiologia
Clusiaceae/microbiologia
Fungos/isolamento & purificação
Folhas de Planta/microbiologia
[Mh] Termos MeSH secundário: Brasil
Ecossistema
Florestas
Fungos/classificação
Fungos/genética
Estações do Ano
Árvores/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE


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[PMID]:26200711
[Au] Autor:Anholeti MC; Duprat RC; Figueiredo MR; Kaplan MA; Santos MG; Gonzalez MS; Ratcliffe NA; Feder D; Paiva SR; Mello CB
[Ad] Endereço:Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BR.
[Ti] Título:Biocontrol evaluation of extracts and a major component, clusianone, from Clusia fluminensis Planch. & Triana against Aedes aegypti.
[So] Source:Mem Inst Oswaldo Cruz;110(5):629-35, 2015 Aug.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Studies evaluated the effects of hexanic extracts from the fruits and flowers of Clusia fluminensis and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti. The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not affect the survival ofAe. aegypti (50 mg/L), however, the flower extracts significantly delayed development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the flower extract, representing 54.85% of this sample composition, showed a highly significant inhibition of survival, killing 93.3% of the larvae and completely blocking development of Ae. aegypti. The results showed, for the first time, high activity of clusianone against Ae. aegypti that both killed and inhibited mosquito development. Therefore, clusianone has potential for development as a biopesticide for controlling insect vectors of tropical diseases. Future work will elucidate the mode of action of clusianone isolated from C. fluminensis.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Clusia/química
Insetos Vetores/efeitos dos fármacos
Larva/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150723
[St] Status:MEDLINE


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[PMID]:25806988
[Au] Autor:Anholeti MC; Paiva SR; Figueiredo MR; Kaplan MA
[Ad] Endereço:Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Chemosystematic aspects of polyisoprenylated benzophenones from the genus Clusia.
[So] Source:An Acad Bras Cienc;87(1):289-301, 2015 Mar.
[Is] ISSN:1678-2690
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Benzophenone derivatives are special metabolites that arouse great scientific interest. The Clusiaceae family is known for producing large amounts of benzophenone derivatives with several isoprene residues on their structures, which are responsible for the observed complexity and structural variety in this class of substances, and also contribute to their biological activities. Clusia is an important genus belonging to Clusiaceae, with 55 different polyisoprenylated benzophenones identified so far. These substances were analyzed from biosynthetic and chemosystematic points of view, allowing the determination of characteristics regarding their production, accumulation and distribution within this genus. Polyisoprenylated benzophenones found in Clusia showed a high prenylation degree, with 2 to 5 isoprene units and a greater occurrence in flowers and fruits. Section Cordylandra showed a very similar occurrence of 2,4,6-trihydroxybenzophenone derivatives and bicyclo[3.3.1]nonane-2,4,9-trione derivatives, the majority of them with 4 isoprene units. In section Anandrogyne there is a predominance of simple 2,4,6-trihydroxy-benzophenone derivatives, with 2 isoprene units, and in Chlamydoclusia predominates bicyclo[3.3.1]nonane-2,4,9-trione derivatives with 4 isoprene units. Although highly prenylated, these substances showed low oxidation indexes, which from an evolutionary perspective corroborates the fact that Clusiaceae is a family in transition, with some common aspects with both basal and derived botanical families.
[Mh] Termos MeSH primário: Benzofenonas/isolamento & purificação
Clusia/química
[Mh] Termos MeSH secundário: Benzofenonas/química
Clusia/classificação
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzophenones); 701M4TTV9O (benzophenone)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150326
[Lr] Data última revisão:
150326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150326
[St] Status:MEDLINE


  5 / 43 MEDLINE  
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[PMID]:25678221
[Au] Autor:Sá-Haiad B; Silva CP; Paula RC; Rocha JF; Machado SR
[Ad] Endereço:Departamento de Botânica, Museu Nacional, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Androecia in two Clusia species: development, structure and resin secretion.
[So] Source:Plant Biol (Stuttg);17(4):816-24, 2015 Jul.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Clusia fluminensis and C. lanceolata are dioecious shrubs having resiniferous flowers with strongly distinct androecia. The aim of this study was to investigate the development and anatomy of their androecia and the ultrastructure, histochemistry and secretory process of their androecium resin glands, examining whether the cellular aspects of resin secretion differed between these two morphologically distinct androecia. Stamens differ, being free in C. fluminensis and clustered in a synandrium in C. lanceolata. Staminode sterility is due to the undifferentiated nature of the anthers in C. lanceolata and degeneration of meiocytes and anther indehiscence in C. fluminensis. Resin is produced in subepidermal cavities and canals with wide lumens. In the secretory stage, epithelial cells present sinuous walls, voluminous nuclei, polymorphic plastids associated with periplastidial reticulum, mitochondria, oil bodies, multivesicular bodies, endoplasmic reticulum and dictyosomes. The resin is released through rupture points on the distal surface of stamens and staminodes, associated with disrupted cavities and canals. Our results show morphological diversity associated with functional similarity. Also, a secretion pattern shared by the two species includes initiation of the secretory process in young floral buds, compartmentalisation of the secretion in pre-anthesis buds and release of secretions at anthesis. Cellular aspects of resin secretion in these species are quite similar, as are the chemical identities of the main components of the floral resins of the genus.
[Mh] Termos MeSH primário: Clusia/ultraestrutura
Flores/ultraestrutura
[Mh] Termos MeSH secundário: Clusia/crescimento & desenvolvimento
Clusia/metabolismo
Flores/crescimento & desenvolvimento
Flores/metabolismo
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Plastídeos
Resinas Vegetais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Resins, Plant)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150624
[Lr] Data última revisão:
150624
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150214
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12314


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[PMID]:25636884
[Au] Autor:Camargo MS; Oliveira MT; Santoni MM; Resende FA; Oliveira-Höhne AP; Espanha LG; Nogueira CH; Cuesta-Rubio O; Vilegas W; Varanda EA
[Ad] Endereço:UNESP - Univ. Estadual Paulista, Faculdade de Ciências Farmacêuticas de Araraquara, Departamento de Ciências Biológicas, CEP 14801-902, Araraquara, São Paulo, Brazil.
[Ti] Título:Effects of nemorosone, isolated from the plant Clusia rosea, on the cell cycle and gene expression in MCF-7 BUS breast cancer cell lines.
[So] Source:Phytomedicine;22(1):153-7, 2015 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breast cancer is the cause of considerable morbidity and mortality in women. While estrogen receptor antagonists have been widely used in breast cancer treatment, patients have increasingly shown resistance to these agents and the identification of novel targeted therapies is therefore required. Nemorosone is the major constituent of the floral resin from Clusia rosea and belongs to the class of polycyclic polyisoprenylated benzophenones of the acylphloroglucinol group. The cytotoxicity of nemorosone in human cancer cell lines has been reported in recent years and has been related to estrogen receptors in breast cancer cells. METHODS: Changes induced by nemorosone in the cell cycle and gene expression of the MCF-7 BUS (estrogen-dependent) breast cancer cell line were analyzed using flow cytometry and the RT(2) Profiler PCR array, respectively. RESULTS: In comparison to breast cancer cells without treatment, nemorosone induced discrete cell cycle arrest in the G1 phase and significant depletion in the G2 phase. Moreover, the compound altered the expression of 19 genes related to different pathways, especially the cell cycle, apoptosis and hormone receptors. CONCLUSION: These promising results justify further studies to clarify mechanisms of action of nemorosone, in view of evaluate the possible use of this benzophenone as adjuvant in the treatment of breast cancer.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Benzofenonas/farmacologia
Neoplasias da Mama/patologia
Ciclo Celular/efeitos dos fármacos
Clusia/química
[Mh] Termos MeSH secundário: Feminino
Flores/química
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Células MCF-7/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Benzophenones); 0 (nemorosone)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150131
[Lr] Data última revisão:
150131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150201
[St] Status:MEDLINE


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[PMID]:24660453
[Au] Autor:de Oliveira EC; Anholeti MC; Domingos TF; Faioli CN; Sanchez EF; de Paiva SR; Fuly AL
[Ti] Título:Inhibitory effect of the plant Clusia fluminensis against biological activities of Bothrops jararaca snake venom.
[So] Source:Nat Prod Commun;9(1):21-5, 2014 Jan.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability of extracts of the plant Clusia fluminensis Planch & Triana (Clusiaceae Lindl.) to neutralize proteolysis, clotting, hemolysis, hemorrhagic and lethality activities of Bothrops jararaca snake venom was studied. Clusianone and lanosterol from the flower and fruit extracts, respectively, were also tested. The extracts of different organs of C. fluminensis inhibited proteolysis and hemolysis induced by B. jararaca venom, but with different potencies. Only the stems prevented blood clotting. Only the acetone extract of the fruit protected mice from hemorrhage while the acetone or methanol extracts prevented mice from death. Clusianone and lanosterol did not inhibit clotting or hemorrhage, but the former inhibited proteolysis and the latter hemolysis.
[Mh] Termos MeSH primário: Antivenenos/análise
Bothrops
Clusia/química
Venenos de Crotalídeos/antagonistas & inibidores
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antivenins); 0 (Crotalid Venoms); 0 (Plant Extracts)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140325
[Lr] Data última revisão:
140325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140326
[St] Status:MEDLINE


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[PMID]:24642847
[Au] Autor:Winter K; Holtum JA
[Ad] Endereço:Smithsonian Tropical Research Institute, PO Box 0843-03092, Balboa, Ancon, Republic of Panama winterk@si.edu.
[Ti] Título:Facultative crassulacean acid metabolism (CAM) plants: powerful tools for unravelling the functional elements of CAM photosynthesis.
[So] Source:J Exp Bot;65(13):3425-41, 2014 Jul.
[Is] ISSN:1460-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Facultative crassulacean acid metabolism (CAM) describes the optional use of CAM photosynthesis, typically under conditions of drought stress, in plants that otherwise employ C3 or C4 photosynthesis. In its cleanest form, the upregulation of CAM is fully reversible upon removal of stress. Reversibility distinguishes facultative CAM from ontogenetically programmed unidirectional C3-to-CAM shifts inherent in constitutive CAM plants. Using mainly measurements of 24h CO2 exchange, defining features of facultative CAM are highlighted in five terrestrial species, Clusia pratensis, Calandrinia polyandra, Mesembryanthemum crystallinum, Portulaca oleracea and Talinum triangulare. For these, we provide detailed chronologies of the shifts between photosynthetic modes and comment on their usefulness as experimental systems. Photosynthetic flexibility is also reviewed in an aquatic CAM plant, Isoetes howellii. Through comparisons of C3 and CAM states in facultative CAM species, many fundamental biochemical principles of the CAM pathway have been uncovered. Facultative CAM species will be of even greater relevance now that new sequencing technologies facilitate the mapping of genomes and tracking of the expression patterns of multiple genes. These technologies and facultative CAM systems, when joined, are expected to contribute in a major way towards our goal of understanding the essence of CAM.
[Mh] Termos MeSH primário: Magnoliopsida/fisiologia
Fotossíntese
Estresse Fisiológico
[Mh] Termos MeSH secundário: Dióxido de Carbono/metabolismo
Clusia/fisiologia
Secas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140320
[St] Status:MEDLINE
[do] DOI:10.1093/jxb/eru063


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[PMID]:24510939
[Au] Autor:Barrera Zambrano VA; Lawson T; Olmos E; Fernández-García N; Borland AM
[Ad] Endereço:School of Biology, Newcastle University, Newcastle upon Tyne NE17RU, UK.
[Ti] Título:Leaf anatomical traits which accommodate the facultative engagement of crassulacean acid metabolism in tropical trees of the genus Clusia.
[So] Source:J Exp Bot;65(13):3513-23, 2014 Jul.
[Is] ISSN:1460-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Succulence and leaf thickness are important anatomical traits in CAM plants, resulting from the presence of large vacuoles to store organic acids accumulated overnight. A higher degree of succulence can result in a reduction in intercellular air space which constrains internal conductance to CO2. Thus, succulence presents a trade-off between the optimal anatomy for CAM and the internal structure ideal for direct C3 photosynthesis. This study examined how plasticity for the reversible engagement of CAM in the genus Clusia could be accommodated by leaf anatomical traits that could facilitate high nocturnal PEPC activity without compromising the direct day-time uptake of CO2 via Rubisco. Nine species of Clusia ranging from constitutive C3 through C3/CAM intermediates to constitutive CAM were compared in terms of leaf gas exchange, succulence, specific leaf area, and a range of leaf anatomical traits (% intercellular air space (IAS), length of mesophyll surface exposed to IAS per unit area, cell size, stomatal density/size). Relative abundances of PEPC and Rubisco proteins in different leaf tissues of a C3 and a CAM-performing species of Clusia were determined using immunogold labelling. The results indicate that the relatively well-aerated spongy mesophyll of Clusia helps to optimize direct C3-mediated CO2 fixation, whilst enlarged palisade cells accommodate the potential for C4 carboxylation and nocturnal storage of organic acids. The findings provide insight on the optimal leaf anatomy that could accommodate the bioengineering of inducible CAM into C3 crops as a means of improving water use efficiency without incurring detrimental consequences for direct C3-mediated photosynthesis.
[Mh] Termos MeSH primário: Dióxido de Carbono/metabolismo
Clusia/anatomia & histologia
Fotossíntese
Folhas de Planta/anatomia & histologia
Transpiração Vegetal
Água/metabolismo
[Mh] Termos MeSH secundário: Clusia/fisiologia
Luz
Células do Mesofilo
Fenótipo
Fosfoenolpiruvato Carboxilase/metabolismo
Folhas de Planta/fisiologia
Proteínas de Plantas/metabolismo
Estômatos de Plantas/anatomia & histologia
Estômatos de Plantas/fisiologia
Ribulose-Bifosfato Carboxilase/metabolismo
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Plant Proteins); 059QF0KO0R (Water); 142M471B3J (Carbon Dioxide); EC 4.1.1.31 (Phosphoenolpyruvate Carboxylase); EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140709
[Lr] Data última revisão:
140709
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140211
[St] Status:MEDLINE
[do] DOI:10.1093/jxb/eru022


  10 / 43 MEDLINE  
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[PMID]:23845547
[Au] Autor:de Souza Ferro JN; da Silva JP; Conserva LM; Barreto E
[Ad] Endereço:Laboratório de Biologia Celular, Universidade Federal de Alagoas, Maceió 57072-970, AL, Brazil.
[Ti] Título:Leaf extract from Clusia nemorosa induces an antinociceptive effect in mice via a mechanism that is adrenergic systems dependent.
[So] Source:Chin J Nat Med;11(4):385-90, 2013 Jul.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts, but its antinociceptive activity has never been characterized. In the present study, the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa G. Mey, called HECn, was examined. Antinociceptive activity was evaluated using acetic acid-induced writhing, formalin, and hot-plate tests. All experiments were carried out on male Swiss mice. The extract (1-400 mg·kg(-1)), given by intraperitoneal route (i.p.) 1 h prior to testing, produced a dose-dependent inhibition on the number of abdominal writhings, with an ID50 of 62 mg·kg(-1). In addition, HECn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 h. In the formalin test, HECn had no effect in the first phase, but produced an analgesic effect on the second phase with the inhibition of licking time. The HECn did not show a significant analgesic effect in the hot plate test. Pretreatment with yohimbine attenuated the antinociceptive effect induced by HECn in the writhing test. However, naloxone, atropine, or haloperidol did not affect antinociception induced by HECn in the writhing test. Together, these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.
[Mh] Termos MeSH primário: Adrenérgicos/administração & dosagem
Analgésicos/administração & dosagem
Clusia/química
Dor/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Masculino
Camundongos
Nociceptividade/efeitos dos fármacos
Dor/psicologia
Fitoterapia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Agents); 0 (Analgesics); 0 (Plant Extracts)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:141224
[Lr] Data última revisão:
141224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130713
[St] Status:MEDLINE



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