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Pesquisa : B01.650.940.800.575.912.250.859.625.333.400 [Categoria DeCS]
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[PMID]:27825990
[Au] Autor:Farahna M; Seke Etet PF; Osman SY; Yurt KK; Amir N; Vecchio L; Aydin I; Aldebasi YH; Sheikh A; Chijuka JC; Kaplan S; Adem A
[Ad] Endereço:Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia. Electronic address: mohammed.farahna@gmail.com.
[Ti] Título:Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat - a type 1 diabetes mellitus model.
[So] Source:J Ethnopharmacol;195:159-165, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mitigate diabetes mellitus metabolic syndrome and complications. AIM OF THE STUDY: We have investigated the neuroprotective properties of a suspension of G. kola seeds in long-term type 1 diabetes mellitus rat model. MATERIALS AND METHODS: Wistar rats, made diabetic by single injection of streptozotocin were monitored for 8 months. Then, they were administered with distilled water or G. kola oral aqueous suspension daily for 30 days. Body weight and glycemia were determined before and after treatment. After sacrifice, cerebella were dissected out and processed for stereological quantification of Purkinje cells. Histopathological and immunohistochemical analyses of markers of neuroinflammation and neurodegeneration were performed. RESULTS: Purkinje cell counts were significantly increased, and histopathological signs of apoptosis and neuroinflammation decreased, in diabetic animals treated with G. kola compared to diabetic rats given distilled water. Glycemia was also markedly improved and body weight restored to non-diabetic control values, following G. kola treatment. CONCLUSIONS: These results suggest that G. kola treatment improved the general condition of long-term diabetic rats and protected Purkinje cells partly by improving the systemic glycemia and mitigating neuroinflammation.
[Mh] Termos MeSH primário: Doenças Cerebelares/prevenção & controle
Cerebelo/efeitos dos fármacos
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 1/tratamento farmacológico
Neuropatias Diabéticas/prevenção & controle
Garcinia kola/química
Hipoglicemiantes/farmacologia
Degeneração Neural
Fármacos Neuroprotetores/farmacologia
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Glicemia/efeitos dos fármacos
Glicemia/metabolismo
Doenças Cerebelares/sangue
Doenças Cerebelares/etiologia
Doenças Cerebelares/patologia
Cerebelo/metabolismo
Cerebelo/patologia
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 1/induzido quimicamente
Neuropatias Diabéticas/sangue
Neuropatias Diabéticas/etiologia
Neuropatias Diabéticas/patologia
Hipoglicemiantes/isolamento & purificação
Neuroimunomodulação/efeitos dos fármacos
Fármacos Neuroprotetores/isolamento & purificação
Fitoterapia
Preparações de Plantas/isolamento & purificação
Plantas Medicinais
Células de Purkinje/efeitos dos fármacos
Células de Purkinje/metabolismo
Células de Purkinje/patologia
Ratos Wistar
Estreptozocina
Fatores de Tempo
Fator de Necrose Tumoral alfa/metabolismo
Receptor fas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Neuroprotective Agents); 0 (Plant Preparations); 0 (Tnfrsf6 protein, rat); 0 (Tumor Necrosis Factor-alpha); 0 (fas Receptor); 5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27842536
[Au] Autor:Jouda JB; Tamokou JD; Mbazoa CD; Douala-Meli C; Sarkar P; Bag PK; Wandji J
[Ad] Endereço:Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
[Ti] Título:Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut.
[So] Source:BMC Complement Altern Med;16(1):462, 2016 Nov 14.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp., an endophytic fungus associated with Garcinia kola nuts. METHODS: The fungus Phomopsis sp. was isolated from the nut of Garcinia kola. The crude extract was prepared from mycelium of Phomopsis sp. by maceration in ethyl acetate and sequentially fractionated by column chromatography. The structures of isolated compounds were elucidated on the basis of spectral studies and comparison with published data. The isolated compounds were evaluated for their antibacterial and anticancer properties by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods respectively. The samples were also tested spectrophotometrically for their hemolytic properties against human red blood cells. RESULTS: The fractionation of the crude extract afforded three known cytochalasins including 18-metoxycytochalasin J (1), cytochalasins H (2) and J (3) together with alternariol (4). The cytochalasin compounds showed different degrees of antibacterial activities against the tested bacterial pathogens. Shigella flexneri was the most sensitive microorganism while Vibrio cholerae SG24 and Vibrio cholerae PC2 were the most resistant. Ampicillin did not show any antibacterial activity against Vibrio cholerae NB2, Vibrio cholerae PC2 and Shigella flexneri at concentrations up to 512 µg/mL, but interestingly, these multi-drug resistant bacterial strains were sensitive to the cytochalasin metabolites. These compounds also showed significant cytotoxic properties against human cancer cells (LC = 3.66-35.69 µg/mL) with low toxicity to normal non-cancer cells. CONCLUSION: The three cytochalasin compounds isolated from the Phomopsis sp. crude extract could be a clinically useful alternative for the treatment of cervical cancer and severe infections caused by MDR Shigella and Vibrio cholerae.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Ascomicetos/química
Citocalasinas/farmacologia
Garcinia kola/microbiologia
Nozes/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Sobrevivência Celular/efeitos dos fármacos
Citocalasinas/química
Citocalasinas/isolamento & purificação
Bactérias Gram-Positivas/efeitos dos fármacos
Células HeLa
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cytochalasins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27686270
[Au] Autor:Popoola TD; Awodele O; Omisanya A; Obi N; Umezinwa C; Fatokun AA
[Ad] Endereço:Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Nigeria. Electronic address: tdpopoola@cmul.edu.ng.
[Ti] Título:Three indigenous plants used in anti-cancer remedies, Garcinia kola Heckel (stem bark), Uvaria chamae P. Beauv. (root) and Olax subscorpioidea Oliv. (root) show analgesic and anti-inflammatory activities in animal models.
[So] Source:J Ethnopharmacol;194:440-449, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Phytochemicals with anti-oxidative and anti-inflammatory properties are known to inhibit tumour initiation, promotion and progression. Hence, there is an increasingly-convincing rationale for employing remedies containing those phytochemicals in the treatment of cancers and also as analgesic and anti-inflammatory adjuvants in therapy. The plants Garcinia kola Heckel (Clusiaceae), stem bark; Uvaria chamae P. Beauv. (Annonaceae), root; and Olax subscorpioidea Oliv. (Olacaceae), root, have been documented to be part of various indigenous anti-cancer regimens. AIM OF THE STUDY: To determine if the three plants exhibit significant anti-oxidative and anti-inflammatory properties. MATERIALS AND METHODS: Using established models, the analgesic and anti-inflammatory activities of the three plants were investigated. RESULTS: Pre-treatment with the plant extracts at 100, 200 and 400mg/kg produced inhibition of writhes; G. kola and U. chamae showed no significant effect on formalin-induced pain, but O. subscorpioidea produced inhibition in both phases of the formalin test. Similarly, while G. kola and U. chamae did not produce any significant inhibitory effect in the xylene-induced ear oedema model, the oedema was significantly reduced by O. subscorpioidea pre-treatment. However, all the three plants significantly inhibited the time-dependent increase in paw circumference in the carrageenan- and formaldehyde-induced rat paw oedema tests, with peak effects observed at 400mg/kg, 6h after the induction of oedema, comparable in some cases to the effects of two standard drugs, the non-steroidal anti-inflammatory drug diclofenac and the anti-inflammatory antibiotic doxycycline. CONCLUSION: We conclude that the three plant extracts possess analgesic and anti-inflammatory properties, thus providing a scientific rationale for their inclusion in some traditional anti-cancer regimens.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Garcinia kola/química
Olacaceae/química
Extratos Vegetais/uso terapêutico
Uvaria/química
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Masculino
Camundongos
Estruturas Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE


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[PMID]:27599375
[Au] Autor:Kalu WO; Okafor PN; Ijeh II; Eleazu C
[Ad] Endereço:Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria. Electronic address: winnnerkalu@gmail.com.
[Ti] Título:Effect of kolaviron, a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats.
[So] Source:Biomed Pharmacother;83:1436-1443, 2016 Oct.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To determine the effect of kolaviron on some biochemical parameters in benign prostatic hyperplasia (BPH) rats. METHODS: BPH was induced in rats using a mixture of dihydrotestosterone and estradiol valerate (10:1). RESULTS: The lethal dose of kolaviron was 3050mg/kg body weight. Body weights, relative heart weight (RHW), relative liver weight (RLW), serum levels of prostate specific antigen, prolactin, estradiol, testosterone, testosterone/estradiol ratio, aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine and prostatic levels of total proteins in the normal rats administered finasteride (standard drug) or kolaviron were not different (P>0.05) from normal control whereas most of these parameters were altered in the disease control except RHW, RLW, AST and ALT. Finasteride (5mg/70kg) or kolaviron (100 and 200mg/kg) ameliorated most of these parameters compared with disease control except RHW, RLW, prolactin, AST, ALT, urea and creatinine (for kolaviron at 100mg/kg). The normal rats administered finasteride or kolaviron had decreased prostate weights (P<0.05) compared with the normal control which results were corroborated by histological assay that also showed that treatment with kolaviron (200mg/kg) or finasteride reversed the histoarchitecture of the prostates of the BPH rats. CONCLUSION: Kolaviron could be useful in the management of BPH.
[Mh] Termos MeSH primário: Flavanonas/uso terapêutico
Flavonoides/uso terapêutico
Garcinia kola
Extratos Vegetais/uso terapêutico
Hiperplasia Prostática/tratamento farmacológico
Hiperplasia Prostática/metabolismo
[Mh] Termos MeSH secundário: Animais
Di-Hidrotestosterona/toxicidade
Estradiol/análogos & derivados
Estradiol/toxicidade
Flavanonas/isolamento & purificação
Flavonoides/isolamento & purificação
Masculino
Extratos Vegetais/isolamento & purificação
Hiperplasia Prostática/induzido quimicamente
Ratos
Ratos Wistar
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavanones); 0 (Flavonoids); 0 (Plant Extracts); 08J2K08A3Y (Dihydrotestosterone); 4TI98Z838E (Estradiol); OKG364O896 (estradiol valerate); PX7M0YV62G (kolaviron)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27548501
[Au] Autor:Akinrinde AS; Omobowale O; Oyagbemi A; Asenuga E; Ajibade T
[Ad] Endereço:a Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, 900001 Nigeria.
[Ti] Título:Protective effects of kolaviron and gallic acid against cobalt-chloride-induced cardiorenal dysfunction via suppression of oxidative stress and activation of the ERK signaling pathway.
[So] Source:Can J Physiol Pharmacol;94(12):1276-1284, 2016 Dec.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping in athletes and horses. We investigated the protective roles of kolaviron (KV), a bi-flavonoid of Garcinia kola, and gallic acid (GA) on cobalt chloride (CoCl )-induced cardiorenal damage in rats. CoCl caused significant increases (p < 0.05) in serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase (XO), urea, creatinine, malondialdehyde, H O , nitric oxide, as well as C-reactive protein expression, along with significant (p < 0.05) reduction in cardiac and renal expression of extracellular signal regulated kinase (ERK) and the activities of superoxide dismutase, catalase, and glutathione S-transferase. KV and GA prevented the toxic effects of CoCl by stimulating ERK expression and reversing Co-induced biochemical changes. Administration of CoCl alone did not significantly alter ECG patterns in the rats, although co-treatment with KV (200 mg/kg) produced QT-segment prolongation and also appeared to potentiate Co hypotension. Histopathology of the heart and kidneys of rats treated with KV and GA confirmed the biochemical data. KV and GA thus protected against cardiac and renal damage in Co intoxication via antioxidant and (or) cell survival mechanisms, possibly involving ERK activation.
[Mh] Termos MeSH primário: Lesão Renal Aguda/prevenção & controle
Cobalto/toxicidade
Flavonoides/administração & dosagem
Ácido Gálico/administração & dosagem
Cardiopatias/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/metabolismo
Animais
Antioxidantes/administração & dosagem
Quimioterapia Combinada
Flavonoides/isolamento & purificação
Garcinia kola
Cardiopatias/induzido quimicamente
Cardiopatias/metabolismo
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Sistema de Sinalização das MAP Quinases/fisiologia
Masculino
Estresse Oxidativo/fisiologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/administração & dosagem
Ratos
Ratos Wistar
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Protective Agents); 3G0H8C9362 (Cobalt); 632XD903SP (Gallic Acid); EVS87XF13W (cobaltous chloride); PX7M0YV62G (kolaviron)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


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[PMID]:27343901
[Au] Autor:Tshibangu PT; Kapepula PM; Kapinga MJK; Lupona HK; Ngombe NK; Kalenda DT; Jansen O; Wauters JN; Tits M; Angenot L; Rozet E; Hubert P; Marini RD; Frédérich M
[Ad] Endereço:University of Liege (ULg), Department of Pharmacy, CIRM, Laboratory of Pharmacognosy, 15, Avenue Hippocrate, B36, B-4000 Liège, Belgium; University of Kinshasa (UNIKIN), Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, B-127 Kinshasa XI, Democratic Republic of the Congo.
[Ti] Título:Fingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines.
[So] Source:J Pharm Biomed Anal;128:382-390, 2016 Sep 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ensuring the health of population and in order to advance towards improved traditional medicines (ITMs). In this paper chromatographic methods were developed for qualitative and quantitative analyses of a per os antimalarial ITM containing Garcinia kola. The identified analytical markers were used to establish TLC and HPLC fingerprints. G. kola seeds were analysed by HPLC to confirm the identity of the extract used by the Congolese manufacturer in the ITM. The main compounds (GB1, GB2, GB-1a and Kolaflavanone) were isolated by preparative TLC and identified by UPLC-MS and NMR. For the quantification of the major compound GB1, a simple and rapid experimental design was applied to develop an LC method, and then its validation was demonstrated using the total error strategy with the accuracy profile as a decision tool. The accurate results were observed within 0.14-0.45mg/mL range of GB1 expressed as naringenin. The extracts used in several batches of the analysed oral solutions contained GB1 (expressed as naringenin) within 2.04-2.43%. Both the fingerprints and the validated LC-DAD were found suitable for the quality control of G. kola-based raw material and finished products, respectively.
[Mh] Termos MeSH primário: Antimaláricos/análise
Biflavonoides/análise
Cromatografia Líquida de Alta Pressão/métodos
Garcinia kola/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antimaláricos/isolamento & purificação
Biflavonoides/isolamento & purificação
Flavanonas/análise
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Antimalarials); 0 (Biflavonoids); 0 (Flavanones); 0 (Plant Extracts); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170812
[Lr] Data última revisão:
170812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160626
[St] Status:MEDLINE


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[PMID]:27089414
[Au] Autor:Kehinde A; Adefisan A; Adebayo O; Adaramoye O
[Ti] Título:Biflavonoid fraction from Garcinia kola seed ameliorates hormonal imbalance and testicular oxidative damage by anti-tuberculosis drugs in Wistar rats.
[So] Source:J Basic Clin Physiol Pharmacol;27(4):393-401, 2016 Jun 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tuberculosis (TB) is a global health problem. The effects of anti-TB drugs on male reproductive system have not been properly evaluated. We investigated the effects of anti-TB drugs on testicular antioxidant indices, sperm characteristics and hormonal levels in rats, and the protective role of kolaviron (KV), a biflavonoid from Garcinia kola seed. METHODS: Twenty-eight male Wistar rats were assigned into four groups and orally treated with corn oil (control), anti-TB drugs [4-Tabs=isoniazid (5 mg/kg), rifampicin (10 mg/kg), pyrazinamide (15 mg/kg) and ethambutol (15 mg/kg) in combination], anti-TB drugs +KV and KV alone (200 mg/kg). Anti-TB drugs and KV were given three times per week for 8 weeks. In vitro, reducing power, inhibition of lipid peroxidation (LPO), diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging effects of KV were examined. RESULTS: KV at 10, 20, 50 and 100 µg/mL showed strong reducing potential and effectively scavenged DPPH and OH radicals in a concentration-dependent manner. Furthermore, KV significantly inhibited LPO in rats' liver homogenate. In vivo, administration of 4-Tabs caused a significant (p<0.05) decrease in body weight gain and weight of testis of rats. Body weight gain and weight of testis decreased by 45% and 36%, respectively, in the 4-Tabs-treated rats. Also, 4-Tabs increased testicular lipid peroxidation by 82%, with a concomitant decrease in antioxidant indices. Testicular reduced glutathione, superoxide dismutase and glutathione peroxidase decreased by 2.2-, 1.9- and 1.6-folds, respectively. Likewise, 4-Tabs markedly decreased sperm count, motility, luteinizing hormone and testosterone. Co-administration of KV with 4-Tabs normalized body weight, enhanced antioxidant system and improved sperm characteristics. CONCLUSIONS: Kolaviron protects male reproductive system from oxidative damage by anti-tuberculosis drugs via the antioxidative mechanism.
[Mh] Termos MeSH primário: Antituberculosos/farmacologia
Biflavonoides/farmacologia
Garcinia kola/química
Hormônios/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Sementes/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Compostos de Bifenilo/farmacologia
Flavonoides/farmacologia
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Picratos/farmacologia
Ratos
Ratos Wistar
Espermatozoides/efeitos dos fármacos
Espermatozoides/metabolismo
Superóxido Dismutase/metabolismo
Testículo/efeitos dos fármacos
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Antitubercular Agents); 0 (Biflavonoids); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Hormones); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); PX7M0YV62G (kolaviron)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE


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[PMID]:27050890
[Au] Autor:Adaramoye OA; Kehinde AO; Adefisan A; Adeyemi O; Oyinlola I; Akanni OO
[Ad] Endereço:Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo, State, Nigeria. aoadaramoye@yahoo.com.
[Ti] Título:Ameliorative Effects of Kolaviron, a Biflavonoid Fraction from Garcinia Kola Seed, on Hepato-renal Toxicity of Anti-tuberculosis Drugs in Wistar Rats.
[So] Source:Tokai J Exp Clin Med;41(1):14-21, 2016 Mar 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tuberculosis (TB) is an infectious disease of international health priority. The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern. PURPOSE: The study was designed to evaluate the toxicity of anti-TB drugs in male Wistar rats and possible ameliorative effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds. METHODS: Twenty-eight rats were assigned into four groups; Group 1 (Control) received corn oil, Group 2 (4-Tabs) received therapeutic doses of INH (5 mg/kg), RIF (10 mg/kg), PZA (15 mg/kg) and ETB (15 mg/kg) in combination, Group 3 (4-Tabs + KV) received INH, RIF, PZA, ETB and KV (200 mg/kg) and Group 4 (KV) received KV (200 mg/kg) by oral gavage three times per week for 8 consecutive weeks. RESULTS: Administration of 4-Tabs caused oxidative stress resulting in significant (p = 0.031, 0.027) increase in malondialdehyde levels in the liver and kidney of rats by 101% and 34%, respectively. Also, 4-Tabs caused significant (p = 0.023-0.035) elevation of serum alanine and aspartate aminotransferases by 41% and 48%, creatinine by 252% and total bilirubin by 89%, respectively. In contrast, hepatic and renal antioxidant indices- reduced glutathione, glutathione peroxidase, glutathione-s-transferase and superoxide dismutase were significantly (p = 0.028-0.039) decreased in 4-Tabs-treated rats. Co-administration of KV with 4-Tabs significantly restored the antioxidant parameters and biochemical indices to near normal. CONCLUSION: These findings suggest that anti-TB drugs elicit oxidative damage in liver and kidney of rats while KV protects against the adverse effects via antioxidative mechanism.
[Mh] Termos MeSH primário: Antioxidantes
Antituberculosos/efeitos adversos
Antituberculosos/toxicidade
Flavonoides/farmacologia
Garcinia kola/química
Rim/metabolismo
Fígado/metabolismo
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alanina Transaminase/metabolismo
Animais
Aspartato Aminotransferases
Etambutol/efeitos adversos
Etambutol/toxicidade
Flavonoides/isolamento & purificação
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Isoniazida/efeitos adversos
Isoniazida/toxicidade
Masculino
Malondialdeído/metabolismo
Pirazinamida/efeitos adversos
Pirazinamida/toxicidade
Ratos Wistar
Rifampina/efeitos adversos
Rifampina/toxicidade
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Antitubercular Agents); 0 (Flavonoids); 2KNI5N06TI (Pyrazinamide); 4Y8F71G49Q (Malondialdehyde); 8G167061QZ (Ethambutol); EC 1.11.1.9 (Glutathione Peroxidase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione); PX7M0YV62G (kolaviron); V83O1VOZ8L (Isoniazid); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE


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[PMID]:26123866
[Au] Autor:Sewani-Rusike CR; Ralebona N; Nkeh-Chungag BN
[Ad] Endereço:Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
[Ti] Título:Dose- and time-dependent effects of Garcinia kola seed extract on sexual behaviour and reproductive parameters in male Wistar rats.
[So] Source:Andrologia;48(3):300-7, 2016 Apr.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to investigate the effects of a crude extract of Garcinia kola on male sexual function after subchronic and chronic treatment periods at different sublethal doses. Adult male Wistar rats were treated orally with 100, 200 and 400 mg kg(-1) of a 70% ethanolic extract of G. kola daily for 56 days. Sexual behaviour studies were performed on days 28 and 50. At termination on day 56, organ weights, sperm count, reproductive hormone levels and testicular histology were assessed. Subchronic and chronic treatment of normal male rats with G. kola extract resulted in overall increase in components of libido, erection and ejaculation in treated rats - with lower doses being more efficient than the higher dose. There was a slight reduction in some components of sexual behaviour with prolonged time of treatment. G. kola treatment at all doses resulted in increased testicular weights, increased sperm count with no change in motility and increased serum testosterone levels with no change in gonadotropin levels. Gross testicular histology was not affected by treatment. We conclude that G. kola seed extract possesses potent aphrodisiac activity in male albino rats with resultant increase in sperm count and testosterone levels.
[Mh] Termos MeSH primário: Garcinia kola
Extratos Vegetais/farmacologia
Sementes
Comportamento Sexual Animal/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ejaculação/efeitos dos fármacos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Wistar
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE
[do] DOI:10.1111/and.12447


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[PMID]:25916484
[Au] Autor:Olajide OJ; Enaibe BU; Bankole OO; Akinola OB; Laoye BJ; Ogundele OM
[Ad] Endereço:Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
[Ti] Título:Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex.
[So] Source:Metab Brain Dis;31(1):25-35, 2016 Feb.
[Is] ISSN:1573-7365
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kolaviron is a phytochemical isolated from Garcina kola (G. kola); a common oral masticatory agent in Nigeria (West Africa). It is a bioflavonoid used--as an antiviral, anti-inflammatory and antioxidant--in relieving the symptoms of several diseases and infections. In this study we have evaluated the neuroprotective and regenerative effect of kolaviron in neurons of the prefrontal cortex (Pfc) before or after exposure to sodium azide (NaN3) induced oxidative stress. Separate groups of animals were treated as follows; kolaviron (200 mg/Kg) for 21 days; kolaviron (200 mg/Kg for 21 days) followed by NaN3 treatment (20 mg/Kg for 5 days); NaN3 treatment (20 mg/Kg for 5 days) followed by kolaviron (200 mg/Kg for 21 days); 1 ml of corn-oil (21 days-vehicle); NaN3 treatment (20 mg/Kg for 5 days). Exploratory activity associated with Pfc function was assessed in the open field test (OFT) following which the microscopic anatomy of the prefrontal cortex was examined in histology (Haematoxylin and Eosin) and antigen retrieval Immunohistochemistry to show astroglia activation (GFAP), neuronal metabolism (NSE), cytoskeleton (NF) and cell cycle dysregulation (p53). Subsequently, we quantified the level of Glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) in the brain tissue homogenate as a measure of stress-related glucose metabolism. Kolaviron (Kv) and Kolaviron/NaN3 treatment caused no prominent change in astroglia density and size while NaN3 and NaN3/Kv induced astroglia activation and scar formation (astrogliosis) in the Pfc when compared with the control. Similarly, Kolaviron and Kv/NaN3 did not alter NSE expression (glucose metabolism) while NaN3 and NaN3/Kv treatment increased cortical NSE expression; thus indicating stress related metabolism. Further studies on enzymes of glucose metabolism (G6PDH and LDH) showed that NaN3 increased LDH while kolaviron reduced LDH in the brain tissue homogenate (P < 0.001). In addition kolaviron treatment before (P < 0.001) or after (P < 0.05) NaN3 treatment also reduced LDH expression; thus supporting its role in suppression of oxidative stress. Interestingly, NF deposition increased in the Pfc after kolaviron treatment while Kv/NaN3 showed no significant change in NF when compared with the control. In furtherance, NaN3 and NaN3/Kv caused a decrease in NF deposition (degeneration). Ultimately, the protective effect of KV administered prior to NaN3 treatment was confirmed through p53 expression; which was similar to the control. However, NaN3 and NaN3/Kv caused an increase in p53 expression in the Pfc neurons (cell cycle dysregulation). We conclude that kolaviron is not neurotoxic when used at 200 mg/Kg BW. Furthermore, 200 mg/Kg of kolaviron administered prior to NaN3 treatment (Kv/NaN3) was neuroprotective when compared with Kolaviron administered after NaN3 treatment (NaN3/Kv). Some of the observed effects of kolaviron administered before NaN3 treatment includes reduction of astroglia activation, absence of astroglia scars, antioxidation (reduced NSE and LDH), prevention of neurofilament loss and cell cycle regulation.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Flavonoides/farmacologia
Garcinia kola/química
Estresse Oxidativo/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Azida Sódica/antagonistas & inibidores
Azida Sódica/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Comportamento Animal/efeitos dos fármacos
Química Encefálica/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Comportamento Exploratório/efeitos dos fármacos
Flavonoides/química
Ativação de Macrófagos/efeitos dos fármacos
Proteínas de Neurofilamentos/metabolismo
Neuroglia/efeitos dos fármacos
Nigéria
Fosfopiruvato Hidratase/metabolismo
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Córtex Pré-Frontal/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Neurofilament Proteins); 0 (Plant Extracts); 968JJ8C9DV (Sodium Azide); EC 4.2.1.11 (Phosphopyruvate Hydratase); PX7M0YV62G (kolaviron)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE
[do] DOI:10.1007/s11011-015-9674-0



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