Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.625.333.600 [Categoria DeCS]
Referências encontradas : 219 [refinar]
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[PMID]:28455132
[Au] Autor:Boonprom P; Boonla O; Chayaburakul K; Welbat JU; Pannangpetch P; Kukongviriyapan U; Kukongviriyapan V; Pakdeechote P; Prachaney P
[Ad] Endereço:Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
[Ti] Título:Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47 and iNOS in nitric oxide deficient rats.
[So] Source:Ann Anat;212:27-36, 2017 Jul.
[Is] ISSN:1618-0402
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:N -Nitro-l-arginine methyl ester (l-NAME)-induced hypertension and cardiovascular remodeling are associated with oxidative stress and inflammation. Garcinia mangostana Linn., has been reported to have antioxidant and anti-inflammatory properties. This study investigated whether G. mangostana pericarp extract (GME) could prevent l-NAME-induced hemodynamic alterations, cardiovascular remodeling, oxidative stress and inflammation in rats. Male Sprague-Dawley rats were given 40mg/kg/day of l-NAME in drinking water to induce hypertension, and were simultaneously treated with GME at a dose of 200mg/kg/day. Rats that received l-NAME for five weeks had high blood pressure, left ventricular hypertrophy and thickening of aortic wall. Vascular superoxide production, plasma malondialdehyde (MDA), and plasma tumor necrosis factor alpha (TNF-α) were significantly increased in l-NAME-hypertensive rats (p<0.05). This was consistent with up-regulation of the p47 NADPH oxidase subunit and iNOS protein expression in aortic tissues (p<0.05). Low levels of plasma nitric oxide metabolites were observed in l-NAME hypertension. GME prevented the development of hypertension and cardiovascular remodeling induced by l-NAME with reduced oxidative stress and inflammation. These data suggest that GME had a protective effect against l-NAME-induced hypertension and cardiovascular remodeling via suppressing p47 NADPH oxidase subunit and iNOS protein expression resulting in enhancing NO bioavailability.
[Mh] Termos MeSH primário: Sistema Cardiovascular/efeitos dos fármacos
Garcinia mangostana/química
Hipertensão/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/efeitos adversos
Depuradores de Radicais Livres/metabolismo
Frutas/química
Hipertensão/induzido quimicamente
Hipertensão/complicações
Hipertensão/metabolismo
Hipertrofia Ventricular Esquerda/induzido quimicamente
Hipertrofia Ventricular Esquerda/etiologia
Hipertrofia Ventricular Esquerda/prevenção & controle
Inflamação/etiologia
Masculino
Artérias Mesentéricas/efeitos dos fármacos
Artérias Mesentéricas/patologia
NADPH Oxidases/antagonistas & inibidores
NADPH Oxidases/metabolismo
NG-Nitroarginina Metil Éster/administração & dosagem
NG-Nitroarginina Metil Éster/efeitos adversos
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Extratos Vegetais/uso terapêutico
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Remodelação Ventricular/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Free Radical Scavengers); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.1 (neutrophil cytosolic factor 1); V55S2QJN2X (NG-Nitroarginine Methyl Ester)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28656594
[Au] Autor:Tousian Shandiz H; Razavi BM; Hosseinzadeh H
[Ad] Endereço:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ti] Título:Review of Garcinia mangostana and its Xanthones in Metabolic Syndrome and Related Complications.
[So] Source:Phytother Res;31(8):1173-1182, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation. This study reviewed all pharmacological effects and molecular pathways of G. mangostana and its xanthones in the management of metabolic syndrome and its complications in in-vitro and in-vivo studies. Based on these studies, mangosteen and its xanthones have good potential to design human studies for controlling and modification of metabolic syndrome and its related disorders such as obesity, disrupted lipid profile, diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Garcinia mangostana/química
Síndrome Metabólica/tratamento farmacológico
Extratos Vegetais/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Obesidade/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5862


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[PMID]:28441346
[Au] Autor:Yang R; Li P; Li N; Zhang Q; Bai X; Wang L; Xiao Y; Sun L; Yang Q; Yan J
[Ad] Endereço:Key Laboratory of Tropical Agro Environment, Ministry of Agriculture and Guangdong Engineering Research Centre for Modern Eco-Agriculture, South China Agricultural University, Guangzhou 510642, China. renyueyang123@126.com.
[Ti] Título:Xanthones from the Pericarp of Garcinia mangostana.
[So] Source:Molecules;22(5), 2017 Apr 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mangosteen ( L.) is one of the most popular tropical fruits (called the "Queen of Fruits"), and is a rich source of oxygenated and prenylated xanthone derivatives. In the present work, phytochemical investigation has resulted in one new prenylated xanthone and 13 known xanthones isolated from the pericarp of . Their structures were established by spectroscopic data analysis, including X-ray diffraction. The new one was further tested for cytotoxic activity against seven cancer cell lines (CNE-1, CNE-2, A549, H490, PC-3, SGC-7901, U87), displaying the half maximal inhibitory concentration (IC50) values 3.35, 4.01, 4.84, 7.84, 6.21, 8.09, and 6.39 µM, respectively. It is noteworthy that the new compound can promote CNE-2 cells apoptosis in late stage, having a remarkable inhibition effect on the side population growth of CNE-2 at 1.26 µM. The bioactive compound was also detected in extract from fresh mangosteen flesh, which indicated that the popular fruit could have potential cytotoxic activity for cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Frutas/química
Garcinia mangostana/química
Extratos Vegetais/química
Xantonas/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Concentração Inibidora 50
Células-Tronco Neoplásicas/efeitos dos fármacos
Células-Tronco Neoplásicas/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Células da Side Population
Xantonas/isolamento & purificação
Xantonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Xanthones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


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[PMID]:28284429
[Au] Autor:Wang MH; Zhang KJ; Gu QL; Bi XL; Wang JX
[Ad] Endereço:Key Laboratory of Drug Design and Optimization of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Pharmacology of mangostins and their derivatives: A comprehensive review.
[So] Source:Chin J Nat Med;15(2):81-93, 2017 Feb.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Mangosteen (Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit's pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer's disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs). Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies of mangostins are also described for further druggability exploration in the future.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Fármacos Cardiovasculares/farmacologia
Garcinia mangostana/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticarcinógenos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Frutas/química
Seres Humanos
Fármacos Neuroprotetores/farmacologia
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anticarcinogenic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Cardiovascular Agents); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Protective Agents); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28254113
[Au] Autor:Xu WK; Jiang H; Yang K; Wang YQ; Zhang Q; Zuo J
[Ad] Endereço:Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
[Ti] Título:Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin.
[So] Source:Kaohsiung J Med Sci;33(3):116-123, 2017 Mar.
[Is] ISSN:1607-551X
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:α-Mangostin (MG) is a versatile bioactive compound isolated from mangosteen and possesses significant pharmacokinetic shortages. To augment the potential clinical efficacy, MG-loaded self-microemulsion (MG-SME) was designed and prepared in this study, and its potential as a drug loading system was evaluated based on the pharmacokinetic performance and tissue distribution feature. The formula of MG-SME was optimized by an orthogonal test under the guidance of ternary phase diagram, and the prepared MG-SME was characterized by encapsulation efficiency, size distribution, and morphology. Optimized high performance liquid chromatography method was employed to determine concentrations of MG and characterize the pharmacokinetic and tissue distribution features of MG in rodents. It was found that diluted MG-SME was characterized as spherical particles with a mean diameter of 24.6 nm and an encapsulation efficiency of 87.26%. The delivery system enhanced the area under the curve of MG by 4.75 times and increased the distribution in lymphatic organs. These findings suggested that SME as a nano-sized delivery system efficiently promoted the digestive tract absorption of MG and modified its distribution in tissues. The targeting feature and high oral bioavailability of MG-SME promised a good clinical efficacy, especially for immune diseases.
[Mh] Termos MeSH primário: Composição de Medicamentos/métodos
Sistemas de Liberação de Medicamentos/métodos
Garcinia mangostana/química
Absorção Gastrointestinal/fisiologia
Xantonas/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Área Sob a Curva
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Emulsões
Análise Fatorial
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Especificidade de Órgãos
Tamanho da Partícula
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Solubilidade
Distribuição Tecidual
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Plant Extracts); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28241761
[Au] Autor:Tjahjani S
[Ad] Endereço:Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia. susy_tjahjani@yahoo.com.
[Ti] Título:Antimalarial activity of Garcinia mangostana L rind and its synergistic effect with artemisinin in vitro.
[So] Source:BMC Complement Altern Med;17(1):131, 2017 Feb 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Malaria especially falciparum malaria still causes high morbidity and mortality in tropical countries. Several factors have been linked to this situation and the most important one is the rapid spread of parasite resistance to the currently available antimalarials, including artemisinin. Artemisinin is the main component of the currently recommended antimalarial, artemisinin based combination therapy (ACT), and it is a free radical generating antimalarial. Garcinia mangostana L (mangosteen) rind contain a lot of xanthone compounds acting as an antioxidant and exhibited antimalarial activity. The aim of this study was to evaluate the antimalarial activity of mangosteen rind extract and its fractions and their interaction with artemisinin against the 3D7 clone of Plasmodium falciparum in vitro. METHODS: Dry ripe mangosteen rind was extracted with ethanol followed by fractionation with hexane, ethylacetate, buthanol, and water consecutively to get ethanol extract, hexane, athylacetate, buthanol, and water fractions. Each of these substances was diluted in DMSO and examined for antimalarial activity either singly or in combination with artemisinin in vitro against Plasmodium falciparum 3D7 clone. Synergism between these substances with artemisinin was evaluated according to certain formula to get the sum of fractional inhibitory concentration 50 (∑FIC ). RESULTS: Analysis of the parasite growth in vitro indicated that IC of these mangosteen rind extract, hexane, ethylacetate, buthanol, and water fraction ranged from 0.41 to > 100 µg/mL. All of the ∑FIC50 were <1. CONCLUSIONS: This study demonstrated a promising antimalarial activity of the extract and fractions of G.mangostana L rind and its synergistic effect with artemisinin. Further study using lead compound(s) isolated from extract and fractions should be performed to identify more accurately their mechanism of antimalarial activities.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Artemisininas/farmacologia
Garcinia mangostana/química
Malária/parasitologia
Extratos Vegetais/farmacologia
Plasmodium falciparum/efeitos dos fármacos
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Sinergismo Farmacológico
Frutas/química
Técnicas In Vitro
Concentração Inibidora 50
Plasmodium falciparum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Plant Extracts); 0 (Xanthones); 9RMU91N5K2 (artemisinine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1649-8


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[PMID]:28208680
[Au] Autor:Narasimhan S; Maheshwaran S; Abu-Yousef IA; Majdalawieh AF; Rethavathi J; Das PE; Poltronieri P
[Ad] Endereço:Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India. asthagiri.herbal@gmail.com.
[Ti] Título:Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana.
[So] Source:Molecules;22(2), 2017 Feb 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that showed high anti-bacterial activity whereas showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Garcinia mangostana/química
Xantonas/química
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Fungos/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Xantonas/síntese química
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28108382
[Au] Autor:Mohamed GA; Al-Abd AM; El-Halawany AM; Abdallah HM; Ibrahim SR
[Ad] Endereço:Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
[Ti] Título:New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines.
[So] Source:J Ethnopharmacol;198:302-312, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer. AIM OF STUDY: Although anticancer activity has been reported for the plant, the goal of the study was designed to isolate and characterize the active metabolites from G. mangostana and measure their cytotoxic properties. In this research, the mechanism of antiproliferative/cytotoxic effects of the tested compounds was investigated. MATERIALS AND METHODS: The CHCl fraction of the air-dried fruit hulls was repeatedly chromatographed on SiO , RP , Diaion HP-20, and polyamide columns to furnish fourteen compounds. The structures of these metabolites were proven by UV, IR, 1D, and 2D NMR measurements and HRESIMS. Additionally, the cytotoxic potential of all compounds was assessed against MCF-7, HCT-116, and HepG2 cell lines using SRB-U assay. Antiproliferative and cell cycle interference effects of potentially potent compounds were tested using DNA content flow cytometry. The mechanism of cell death induction was also studied using annexin-V/PI differential staining coupled with flow cytometry. RESULTS: The CHCl soluble fraction afforded two new xanthones: mangostanaxanthones V (1) and VI (2), along with twelve known compounds: mangostanaxanthone IV (3), ß-mangostin (4), garcinone E (5), α-mangostin (6), nor-mangostin (7), garcimangosone D (8), aromadendrin-8-C-ß-D-glucopyranoside (9), 1,2,4,5-tetrahydroxybenzene (10), 2,4,3`-trihydroxybenzophenone-6-O-ß-glucopyranoside (11), maclurin-6-O-ß-D-glucopyranoside (rhodanthenone) (12), epicatechin (13), and 2,4,6,3`,5`-pentahydroxybenzophenone (14). Only compound 5 showed considerable antiproliferative/cytotoxic effects with IC 's ranging from 15.8 to 16.7µM. Compounds 3, 4, and 6 showed moderate to weak cytotoxic effects (IC 's ranged from 45.7 to 116.4µM). Using DNA content flow cytometry, it was found that only 5 induced significant cell cycle arrest at G /G -phase which is indicative of its antiproliferative properties. Additionally, by using annexin V-FITC/PI differential staining, 5 induced cells killing effect via the induction of apoptosis and necrosis in both HepG and HCT116 cells. Compound 3 produce necrosis and apoptosis only in HCT116 cells. On contrary, 6 induced apoptosis and necrosis in HepG cells and moderate necrosis in HCT116 cells. CONCLUSION: Fourteen compounds were isolated from chloroform fraction of G. mangostana fruit hulls. Cytotoxic properties exhibited by the isolated xanthones from G. mangostana reinforce the avail of it as a natural cytotoxic agent against various cancers. These evidences could provide relevant bases for the scientific rationale of using G. mangostana in anti-cancer treatment.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Garcinia mangostana/química
Extratos Vegetais/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/patologia
Carcinoma Hepatocelular/tratamento farmacológico
Carcinoma Hepatocelular/patologia
Neoplasias Colorretais/tratamento farmacológico
Neoplasias Colorretais/patologia
Feminino
Citometria de Fluxo
Frutas
Células HCT116
Células Hep G2
Seres Humanos
Concentração Inibidora 50
Neoplasias Hepáticas/tratamento farmacológico
Neoplasias Hepáticas/patologia
Células MCF-7
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Xantonas/administração & dosagem
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Xanthones)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE


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[PMID]:28081600
[Au] Autor:Chen S; Han K; Li H; Cen J; Yang Y; Wu H; Wei Q
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology Beijing Key Laboratory, College of Life Sciences, Beijing Normal University , Beijing 100875, People's Republic of China.
[Ti] Título:Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in Mice.
[So] Source:J Agric Food Chem;65(4):846-857, 2017 Feb 01.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isogarcinol (YDIS), a natural compound extracted from Garcinia mangostana L., has a significant immunosuppressive effect on systemic lupus erythematosus and rheumatoid arthritis. This paper reports that it reduced imiquimod-induced psoriasis-like skin lesions in mice. It strongly attenuated the aberrant proliferation and differentiation of keratinocytes. Moreover, the expression of genes involving the interleukin-23 (IL-23)/T-helper 17 (Th17) axis was significantly inhibited in the dorsal skin of the YDIS-treated mice, as was that of the other pro-inflammatory factors TNF-α, IL-2, and even interferon (IFN)-γ. Furthermore, YDIS prevented the abnormal distribution of T cell types and suppressed the differentiation of CD4 T cells into Th17 cells in the spleens of mice exposed to imiquimod. Interestingly, it elevated numbers of regulatory T cells (Tregs) in the spleen and boosted IL-10 expression in the skin. In agreement with the above, YDIS increased serum IL-10 and reduced serum IL-17. It also caused less damage to the liver and, especially, kidneys of mice than cyclosporine A (CsA). In vitro, YDIS caused more death of HaCaT keratinocytes than CsA. It also strongly inhibited inflammatory factor expression in lipopolysaccharide (LPS)-stimulated HaCaT cells. These findings suggest that YDIS is a promising immunosuppressive agent for treating psoriasis.
[Mh] Termos MeSH primário: Aminoquinolinas/administração & dosagem
Garcinia mangostana/química
Extratos Vegetais/administração & dosagem
Psoríase/tratamento farmacológico
Pele/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Seres Humanos
Interleucina-2/genética
Interleucina-2/imunologia
Interleucina-23/genética
Interleucina-23/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Psoríase/genética
Psoríase/imunologia
Pele/efeitos dos fármacos
Linfócitos T Reguladores/efeitos dos fármacos
Linfócitos T Reguladores/imunologia
Células Th17/efeitos dos fármacos
Células Th17/imunologia
Fator de Necrose Tumoral alfa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoquinolines); 0 (Interleukin-2); 0 (Interleukin-23); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); P1QW714R7M (imiquimod)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05207


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[PMID]:27824406
[Au] Autor:Zhang KJ; Gu QL; Yang K; Ming XJ; Wang JX
[Ad] Endereço:Key Laboratory of Drug Design and Optimization of Jiangsu Province, China Pharmaceutical University, Nanjing, China.
[Ti] Título:Anticarcinogenic Effects of α-Mangostin: A Review.
[So] Source:Planta Med;83(3-04):188-202, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cancer chemoprevention is a promising strategy taken to block, reverse, or retard carcinogenesis. -Mangostin, a natural xanthone isolated from the pericarps of mangosteen, represents one of the most studied chemopreventive agents. This compound has been reported to interfere with all the major stages of carcinogenesis: initiation, promotion, and progression. A number of mechanisms have been proposed for its anticarcinogenic activities. This review summarizes the current knowledge on the mechanisms that contribute to the observed activity of -mangostin related to (i) modulation of carcinogenic biotransformation and mitigation of oxidative damage, (ii) induction of growth arrest and apoptosis, (iii) suppression of angiogenesis and metastasis, and (iv) combination with clinical chemotherapy drugs enhancing their efficacy and decreasing the toxic side effects. In addition, pharmacokinetic and toxicological studies of -mangostin have also been highlighted in this review. Despite an overwhelming amount of knowledge in preclinical studies, there was almost no translation of -mangostin into the clinic. It is hoped that continuous extensive and profound research will lead to the application of -mangostin from experimental studies to evidence-based, clinically applicable pharmacotherapy.
[Mh] Termos MeSH primário: Anticarcinógenos/farmacologia
Carcinogênese/efeitos dos fármacos
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticarcinógenos/efeitos adversos
Anticarcinógenos/farmacocinética
Anticarcinógenos/uso terapêutico
Garcinia mangostana/química
Seres Humanos
Xantonas/efeitos adversos
Xantonas/farmacocinética
Xantonas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-119651



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