Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.625.500 [Categoria DeCS]
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  1 / 1985 MEDLINE  
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[PMID]:28450246
[Au] Autor:Günes S; Tihminlioglu F
[Ad] Endereço:Graduate Program of Biogineering, Izmir Institute of Technology, Izmir, 35430, Turkey.
[Ti] Título:Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material.
[So] Source:Int J Biol Macromol;102:933-943, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Recent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25-1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films. Antimicrobial test was performed by disc diffusion method and the growth inhibition effects of the films including different amount of H. perforatum oil were investigated on Escherichia coli and Staphylococcus aureus. WVP increased with oil incorporation and the highest value was obtained for 0.25% oil concentration.The highest strain value was obtained in 0.25% oil content films although tensile stress decreased with increasing oil content. H. perforatum oil incorporated films had antimicrobial effect on both microorganisms. Chitosan based films had no cytotoxic effects on NIH3T3fibroblast cells and provided a good surface for cell attachment and proliferation. The results showed that the H. perforatum incorporated chitosan films seems to be a potential and novel biomaterial for wound healing applications.
[Mh] Termos MeSH primário: Bandagens
Materiais Biocompatíveis/química
Materiais Biocompatíveis/farmacologia
Quitosana/química
Hypericum/química
Óleos Vegetais/química
Cicatrização
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Bandagens/microbiologia
Adesão Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Fenômenos Mecânicos
Camundongos
Células NIH 3T3
Permeabilidade
Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Biocompatible Materials); 0 (Plant Oils); 0 (Steam); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  2 / 1985 MEDLINE  
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[PMID]:29199980
[Au] Autor:Stewart C; Woods K; Macias G; Allan AC; Hellens RP; Noel JP
[Ad] Endereço:Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
[Ti] Título:Molecular architectures of benzoic acid-specific type III polyketide synthases.
[So] Source:Acta Crystallogr D Struct Biol;73(Pt 12):1007-1019, 2017 Dec 01.
[Is] ISSN:2059-7983
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biphenyl synthase and benzophenone synthase constitute an evolutionarily distinct clade of type III polyketide synthases (PKSs) that use benzoic acid-derived substrates to produce defense metabolites in plants. The use of benzoyl-CoA as an endogenous substrate is unusual for type III PKSs. Moreover, sequence analyses indicate that the residues responsible for the functional diversification of type III PKSs are mutated in benzoic acid-specific type III PKSs. In order to gain a better understanding of structure-function relationships within the type III PKS family, the crystal structures of biphenyl synthase from Malus × domestica and benzophenone synthase from Hypericum androsaemum were compared with the structure of an archetypal type III PKS: chalcone synthase from Malus × domestica. Both biphenyl synthase and benzophenone synthase contain mutations that reshape their active-site cavities to prevent the binding of 4-coumaroyl-CoA and to favor the binding of small hydrophobic substrates. The active-site cavities of biphenyl synthase and benzophenone synthase also contain a novel pocket associated with their chain-elongation and cyclization reactions. Collectively, these results illuminate structural determinants of benzoic acid-specific type III PKSs and expand the understanding of the evolution of specialized metabolic pathways in plants.
[Mh] Termos MeSH primário: Aciltransferases/química
Hypericum/enzimologia
Malus/enzimologia
[Mh] Termos MeSH secundário: Acil Coenzima A/química
Acil Coenzima A/metabolismo
Aciltransferases/metabolismo
Carbono-Carbono Ligases/química
Carbono-Carbono Ligases/metabolismo
Domínio Catalítico
Clonagem Molecular
Cristalografia por Raios X
Evolução Molecular
Modelos Moleculares
Estrutura Molecular
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acyl Coenzyme A); 6756-74-7 (benzoyl-coenzyme A); EC 2.3.- (Acyltransferases); EC 2.3.1.74 (flavanone synthetase); EC 6.4.- (Carbon-Carbon Ligases); EC 6.4.- (benzophenone synthase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1107/S2059798317016618


  3 / 1985 MEDLINE  
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[PMID]:29190454
[Au] Autor:Mathioudaki A; Berzesta A; Kypriotakis Z; Skaltsa H; Heilmann J
[Ad] Endereço:Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece; Universität Regensburg, Pharmaceutical Biology, Universitätsstr. 31, D-93053, Regensburg, Germany.
[Ti] Título:Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece).
[So] Source:Phytochemistry;146:1-7, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thirteen compounds were isolated from the aerial parts of Hypericum kelleri Bald., growing as an endemic on the island of Crete (Greece). These compounds comprise four previously unknown prenylated xanthones 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine A), 1,2-dihydro-3,6,8-trihydroxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine B), 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1-bi(3-methylbut-2-enyl)xanthen-2,9-dione (6-methylpatulone), (R/S)-1,3,5-trihydroxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-6-methoxy-9H-xanthen-9-one ((2″R/S)-kellerine C) and the hitherto undescribed depsidone (R/S)-1,3,6-trihydroxy-5-methoxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-11Η-dibenzo[b,e] [1,4]dioxepin-9-one ((2″R/S)-creticine). As known compounds, brevipsidone D, 4-geranyl-2-(2'-isobutyryl)-phloroglucinol, 4-geranyl-2-(2'-methylbutyryl)-phloroglucinol, I3, II8-biapigenin, quercetin, avicularin, pseudohypericin and neochlorogenic acid have been isolated. The structures were elucidated on the basis of their 1D, 2D NMR, CD and MS data. The study confirms the typical occurrence of xanthones in Hypericum section Oligostema (Boiss.) Stef., and is also the first report on the simultaneous isolation of acylphloroglucinols in this section. Furthermore the first evidence of depsidones in the genus Hypericum L. is reported. Cytotoxicity was investigated in HeLa cells for prenylated xanthones and the depsidones. Both triprenylated 1,2-dihydroxanthones (kellerine A and B) showed significant in vitro cytotoxicity with IC values of 2.5 ± 0.1 (kellerine A) and 5.9 ± 0.9 (kellerine B) µM, whereas other compounds were less cytotoxic (IC > 20 µM).
[Mh] Termos MeSH primário: Hypericum/química
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Grécia
Células HeLa
Seres Humanos
Estrutura Molecular
Fenóis/química
Fenóis/isolamento & purificação
Componentes Aéreos da Planta/química
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  4 / 1985 MEDLINE  
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[PMID]:28885074
[Au] Autor:Soleymani S; Bahramsoltani R; Rahimi R; Abdollahi M
[Ad] Endereço:a Department of Traditional Pharmacy, School of Traditional Medicine , Tehran University of Medical Sciences , Tehran , Iran.
[Ti] Título:Clinical risks of St John's Wort (Hypericum perforatum) co-administration.
[So] Source:Expert Opin Drug Metab Toxicol;13(10):1047-1062, 2017 Oct.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: St. John's wort (SJW) is a common medicinal herb used for the treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW, plays an important role in the induction of cytochrome P450 enzymes (CYP) and P-glycoprotein transporter (P-gp), and therefore, affects the pharmacokinetics of various drugs. There are several clinical studies demonstrating the interaction of SJW with the metabolism of conventional drugs which may cause life-threatening events. Areas covered: This review focuses on human studies that have evaluated pharmacokinetic alterations of conventional drugs in concomitant use with different SJW preparations. Expert opinion: SJW preparations have demonstrated clinically important interactions with several classes of conventional drugs such as immunosuppressants, anticancer agents, cardiovascular drugs, oral contraceptives, and lipid lowering agents that caused life-threatening events in several cases. The patient information label on the SJW products should provide enough information regarding the possible risk of interaction. Hyperforin seems to be the major ingredient responsible for CYP and P-gp inducing activity of SJW; thus, hyperforin-free products may be future candidates to decrease SJW's drug interactions.
[Mh] Termos MeSH primário: Interações Ervas-Drogas
Hypericum/química
Preparações de Plantas/administração & dosagem
[Mh] Termos MeSH secundário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo
Animais
Sistema Enzimático do Citocromo P-450/efeitos dos fármacos
Depressão/tratamento farmacológico
Seres Humanos
Farmacocinética
Floroglucinol/análogos & derivados
Floroglucinol/isolamento & purificação
Floroglucinol/farmacologia
Preparações de Plantas/efeitos adversos
Preparações de Plantas/farmacologia
Terpenos/isolamento & purificação
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Plant Preparations); 0 (Terpenes); 9035-51-2 (Cytochrome P-450 Enzyme System); DHD7FFG6YS (Phloroglucinol); RM741E34FP (hyperforin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2017.1378342


  5 / 1985 MEDLINE  
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[PMID]:28675829
[Au] Autor:Liu R; Su Y; Yang J; Wang A
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
[Ti] Título:Polyprenylated acylphloroglucinols from Hypericum scabrum.
[So] Source:Phytochemistry;142:38-50, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fourteen phloroglucinols, named hyperciumoxide A-N, and a known compound were isolated from air-dried aerial parts of Hypericum scabrum. The structures of these compounds were deduced on the basis of extensive 1D- and 2D-NMR experiments. Hepatoprotective properties against D-galactosamine-induced HL-7702 cell damage of isolated compounds were evaluated. Meanwhile, these compounds were also tested for antidepressant activity by inhibiting reuptake of tritiated serotonin ([ H]-5-HT) and Noradrenalinet ([ H]-NE) in rat brain synaptosomes.
[Mh] Termos MeSH primário: Antidepressivos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Compostos Heterocíclicos de Anel em Ponte/farmacologia
Hypericum/química
Floroglucinol/isolamento & purificação
Componentes Aéreos da Planta/química
Antagonistas da Serotonina/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Antidepressivos/química
Antidepressivos/farmacologia
Encéfalo/efeitos dos fármacos
Cicloexanonas/química
Cicloexanonas/isolamento & purificação
Cicloexanonas/farmacologia
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Células HL-60
Compostos Heterocíclicos de Anel em Ponte/química
Seres Humanos
Fígado/efeitos dos fármacos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Floroglucinol/análogos & derivados
Floroglucinol/química
Floroglucinol/farmacologia
Ratos
Antagonistas da Serotonina/química
Antagonistas da Serotonina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Cyclohexanones); 0 (Drugs, Chinese Herbal); 0 (Heterocyclic Compounds, Bridged-Ring); 0 (Serotonin Antagonists); 0 (hyperciumoxide N); 5QOR3YM052 (cyclohexanone); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  6 / 1985 MEDLINE  
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[PMID]:28647480
[Au] Autor:Mandrone M; Scognamiglio M; Fiorentino A; Sanna C; Cornioli L; Antognoni F; Bonvicini F; Poli F
[Ad] Endereço:Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio, 42, 40126 Bologna, Italy. Electronic address: manuela.mandrone2@unibo.it.
[Ti] Título:Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum.
[So] Source:Fitoterapia;120:184-193, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The phytochemical profile, antioxidant activity and α-glucosidase inhibitory activity of Hypericum scruglii Bacchetta, Brullo et Salmeri and Hypericum hircinum L. were analyzed and compared to those of the best-known Hypericum perforatum L. Samples were prepared using three different extraction methods (maceration in 70% ethanol, extraction in MeOH/phosphate buffer and decoction), the influence of which on the metabolic profile and bioactivities are discussed. H. scruglii and H. hircinum extracted in 70% ethanol strongly inhibited α-glucosidase (IC 7.25 and 14.05µg/ml, respectively), which is a valuable enzymatic target for treating metabolic disorders, while H. perforatum was found to be less powerful than the other two species in all the performed biological tests. The phytochemical profile was analyzed by NMR, HPLC-DAD and HPLC-FLD, revealing remarkable differences among the species. In particular, H. scruglii, which is a species endemic to Sardinia Island (Italy), was particularly enriched in two phloroglucinol-derivatives identified by means of 2D NMR and LC/MS/MS experiments as 3-geranyl-1-(2'-methylbutanoyl)-phloroglucinol and 3-geranyl-1-(2'-methylpropanoyl)-phloroglucinol.
[Mh] Termos MeSH primário: Inibidores de Glicosídeo Hidrolases/química
Hypericum/química
Compostos Fitoquímicos/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Cercopithecus aethiops
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Hypericum/classificação
Itália
Floroglucinol/análogos & derivados
Floroglucinol/química
Floroglucinol/isolamento & purificação
Compostos Fitoquímicos/isolamento & purificação
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Quercetina/análogos & derivados
Quercetina/química
Quercetina/isolamento & purificação
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glycoside Hydrolase Inhibitors); 0 (Phytochemicals); 0 (Plant Extracts); 2Y8906LC5P (quercitrin); 9IKM0I5T1E (Quercetin); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


  7 / 1985 MEDLINE  
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[PMID]:28557380
[Au] Autor:Heinrich M; Lorenz P; Daniels R; Stintzing FC; Kammerer DR
[Ad] Endereço:WALA Heilmittel GmbH, Department of Analytical Development & Research, Section Phytochemical Research, Dorfstraße 1, DE-73087 Bad, Boll/Eckwälden.
[Ti] Título:Lipid and Phenolic Constituents from Seeds of Hypericum perforatum L. and Hypericum tetrapterum Fr. and their Antioxidant Activity.
[So] Source:Chem Biodivers;14(8), 2017 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Seeds of Hypericum perforatum and H. tetrapterum were extracted with dichloromethane and methanol and investigated by chromatographic and mass spectrometric methods. Both species yielded a fatty oil fraction amounting to 30.5% and 18.0% of the seed weight, respectively. Linoleic acid (C18:2n-6) was shown to be the predominant fatty acid constituent. Moreover, xanthone derivatives, i.e. tetrahydroxyxanthones (THX), xanthone-glycosides and xanthone-sulfonates, were assigned in methanolic extracts. For structure elucidation, one representative xanthone, namely 1,3,6,7-THX, was synthesized and analyzed via HPLC-DAD/MS and GC/MS. Total THX contents were quantitated applying a validated HPLC-DAD method, resulting in 1.25 g/kg (H. perforatum) and 0.27 g/kg (H. tetrapterum), respectively. Moreover, the free radical scavenging capacity of the methanol extracts was tested using the DPPH antioxidant assay. Both, H. perforatum (IC = 8.7 mg/l) and 1,3,6,7-THX (IC = 3.0 mg/l), exhibited good DPPH free radical scavenging activity compared to Trolox (IC = 6.6 mg/l).
[Mh] Termos MeSH primário: Hypericum/química
Lipídeos/química
Lipídeos/farmacologia
Fenóis/química
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/farmacologia
Cromatografia Líquida de Alta Pressão
Cromatografia Gasosa-Espectrometria de Massas
Hypericum/metabolismo
Lipídeos/análise
Espectroscopia de Ressonância Magnética
Oxirredução/efeitos dos fármacos
Fenóis/análise
Sementes/química
Sementes/metabolismo
Espectrometria de Massas por Ionização por Electrospray
Xantonas/análise
Xantonas/química
Xantonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Lipids); 0 (Phenols); 0 (Plant Extracts); 0 (Xanthones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700100


  8 / 1985 MEDLINE  
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[PMID]:28555608
[Au] Autor:Egilmez OK; Kökten N; Kalcioglu MT
[Ad] Endereço:Clinic of Otolaryngology, Malkara State Hospital, Tekirdag, Turkey. mtkalcioglu@hotmail.com.
[Ti] Título:Does Hypericum Perforatum Have Inflammatory or Anti-Inflammatory Effects?
[So] Source:J Int Adv Otol;13(1):151, 2017 Apr.
[Is] ISSN:1308-7649
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Hypericum
Extratos Vegetais/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Extratos Vegetais/química
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.5152/iao.2017.3457


  9 / 1985 MEDLINE  
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[PMID]:28480399
[Au] Autor:Okmen G; Balpinar N
[Ad] Endereço:Department of Biology, Faculty of Science, University of Mugla Sitki Kocman, 48000 Mugla, Turkey.
[Ti] Título:THE BIOLOGICAL ACTIVITIES OF L.
[So] Source:Afr J Tradit Complement Altern Med;14(1):213-218, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed in bacteria. Today's researches are focused on discovering and using new antibiotics against bacteria. OBJECTIVE: The aim of this work was to discover the antibacterial effects of L. extracts against mastitis pathogens, and its other biological activities. MATERIAL AND METHODS: Kirby-Bauer assay was applied to the extracts. The other antibacterial activity was MIC for plant extracts. The non-enzymatic antioxidant activity was found using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH). RESULTS: The extract was showed maximum inhibition zone against two bacteria (Coagulase-negative -33 and 37; CNS 33 and 37), and the zone was 17 mm. A bacterium (CNS - 22) showed the lowest sensitivity to 812.5 µg/mL concentration. In addition, the extract was tried against the stable DPPH for antioxidant activity. As a result, the extract showed a strength antioxidant activity. Trolox equivalent is 0.83 mM. CONCLUSION: The extract of have antibacterial, antioxidant and antimutagenic potentials.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções Bacterianas/veterinária
Hypericum/química
Mastite Bovina/microbiologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antioxidantes/química
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Infecções Bacterianas/tratamento farmacológico
Infecções Bacterianas/microbiologia
Bovinos
Feminino
Flores/química
Mastite Bovina/tratamento farmacológico
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i1.23


  10 / 1985 MEDLINE  
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[PMID]:28445039
[Au] Autor:Guo Y; Zhang N; Chen C; Huang J; Li XN; Liu J; Zhu H; Tong Q; Zhang J; Luo Z; Xue Y; Zhang Y
[Ti] Título:Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.
[So] Source:J Nat Prod;80(5):1493-1504, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The new polyprenylated acylphloroglucinol derivatives 1-15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh (OCOCF ) -induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicyclo[3.3.1]nonane core. Hyperforatins G (10) and H (11) are similarly the first examples of naturally occurring [3.3.1]-type polycyclic prenylated acylphloroglucinols possessing a carbonyl functionality at C-32. The compounds were tested for their acetylcholinesterase (AChE) inhibitory activities and cytotoxic activities against a panel of human tumor cell lines. Compounds 3, 5, 6, 8, and 9 exerted moderate inhibitory activities (IC 3.98-9.13 µM) against AChE.
[Mh] Termos MeSH primário: Acetilcolinesterase/química
Acetilcolinesterase/efeitos dos fármacos
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Floroglucinol/análogos & derivados
Floroglucinol/isolamento & purificação
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Linhagem Celular Tumoral
Dicroísmo Circular
Seres Humanos
Hypericum
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Floroglucinol/química
Floroglucinol/farmacologia
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (furohyperforin); 0 (hyperforatin G); 0 (hyperforatin H); DHD7FFG6YS (Phloroglucinol); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01178



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