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Pesquisa : B01.650.940.800.575.912.250.859.750.200.750 [Categoria DeCS]
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[PMID]:29236500
[Au] Autor:Liu X; Liu T; Zhang Y; Xin F; Mi S; Wen B; Gu T; Shi X; Wang F; Sun L
[Ad] Endereço:Laboratory of Biomanufacturing and Food Engineering, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences , Beijing 100193, P.R. China.
[Ti] Título:Structural Insights into the Thermophilic Adaption Mechanism of Endo-1,4-ß-Xylanase from Caldicellulosiruptor owensensis.
[So] Source:J Agric Food Chem;66(1):187-193, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Xylanases (EC 3.2.1.8) are a kind of enzymes degrading xylan to xylooligosaccharides (XOS) and have been widely used in a variety of industrial applications. Among them, xylanases from thermophilic microorganisms have distinct advantages in industries that require high temperature conditions. The CoXynA gene, encoding a glycoside hydrolase (GH) family 10 xylanase, was identified from thermophilic Caldicellulosiruptor owensensis and was overexpressed in Escherichia coli. Recombinant CoXynA showed optimal activity at 90 °C with a half-life of about 1 h at 80 °C and exhibited highest activity at pH 7.0. The activity of CoXynA activity was affected by a variety of cations. CoXynA showed distinct substrate specificities for beechwood xylan and birchwood xylan. The crystal structure of CoXynA was solved and a molecular dynamics simulation of CoXynA was performed. The relatively high thermostability of CoXynA was proposed to be due to the increased overall protein rigidity resulting from the reduced length and fluctuation of Loop 7.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Endo-1,4-beta-Xilanases/química
Endo-1,4-beta-Xilanases/metabolismo
Firmicutes/enzimologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Betula/química
Cristalografia por Raios X
Endo-1,4-beta-Xilanases/genética
Estabilidade Enzimática
Escherichia coli/genética
Fagus/química
Concentração de Íons de Hidrogênio
Cinética
Simulação de Dinâmica Molecular
Conformação Proteica
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Especificidade por Substrato
Madeira/química
Xilanos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Recombinant Proteins); 0 (Xylans); EC 3.2.1.8 (Endo-1,4-beta Xylanases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03607


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[PMID]:28450660
[Au] Autor:Kong B; Chen L; Kasahara Y; Sumida A; Ono K; Wild J; Nagatake A; Hatano R; Hara T
[Ad] Endereço:Institute of Low Temperature Science, Hokkaido University.
[Ti] Título:Understory Dwarf Bamboo Affects Microbial Community Structures and Soil Properties in a Betula ermanii Forest in Northern Japan.
[So] Source:Microbes Environ;32(2):103-111, 2017 Jun 24.
[Is] ISSN:1347-4405
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In order to understand the relationships between understory bamboo and soil properties, we compared microbial community structures in the soil of a Betula ermanii boreal forest with Sasa kurilensis present and removed using high-throughput DNA sequencing. The presence of understory S. kurilensis strongly affected soil properties, including total carbon, total nitrogen, nitrate, and the C:N ratio as well as relative soil moisture. Marked differences were also noted in fungal and bacterial communities between plots. The relative abundance of the fungal phylum Ascomycota was 13.9% in the Sasa-intact plot and only 0.54% in the Sasa-removed plot. Among the Ascomycota fungi identified, the most prevalent were members of the family Pezizaceae. We found that the abundance of Pezizaceae, known to act as mycorrhizal fungi, was related to the amount of total carbon in the Sasa-intact plot. The relative abundance of Proteobacteria was significantly higher, whereas those of Planctomycetes and Actinobacteria were lower in the Sasa-intact plot than in the Sasa-removed plot. Furthermore, the results obtained suggest that some species of the phylum Planctomycetes are more likely to occur in the presence of S. kurilensis. Collectively, these results indicate that the presence of S. kurilensis affects microbial communities and soil properties in a B. ermanii boreal forest.
[Mh] Termos MeSH primário: Betula
Florestas
Sasa/crescimento & desenvolvimento
Microbiologia do Solo
[Mh] Termos MeSH secundário: Bactérias/classificação
Carbono/análise
Fungos/classificação
Sequenciamento de Nucleotídeos em Larga Escala
Japão
Nitrogênio/análise
Análise de Sequência de DNA
Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 7440-44-0 (Carbon); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1264/jsme2.ME16154


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[PMID]:28460081
[Au] Autor:Lihavainen J; Ahonen V; Keski-Saari S; Sõber A; Oksanen E; Keinänen M
[Ad] Endereço:Department of Environmental and Biological Sciences, University of Eastern Finland, PO Box 111, 80101 Joensuu, Finland.
[Ti] Título:Low vapor pressure deficit reduces glandular trichome density and modifies the chemical composition of cuticular waxes in silver birch leaves.
[So] Source:Tree Physiol;37(9):1166-1181, 2017 Sep 01.
[Is] ISSN:1758-4469
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Cuticular wax layer is the first barrier against the outside environment and the first defense encountered by herbivores and pathogens. The effects of environmental factors on cuticular chemistry, and on the formation of glandular trichomes that account for the storage and secretion of lipophilic compounds to the leaf surface are poorly understood. Low vapor pressure deficit (VPD) has shown to reduce the nitrogen (N) status of plants. Thus, we studied the effects of elevated air humidity, indicated as VPD, and the effect of N fertilization on cuticular waxes and glandular trichome density in silver birch (Betula pendula Roth). Experiments were carried out in growth chambers with juvenile plants and in a long-term field experiment with older trees. Low VPD reduced the glandular trichome density in both experiments, in chamber and in field. The contents of the major triterpenoid and flavonoid aglycones correlated positively with glandular trichome density, which supports the role of trichomes in the exudation of secondary compounds to the leaf surface. A closer examination of the cuticular wax chemistry in the chamber experiment revealed that low VPD and N supply affected the composition of cuticular waxes, but not the total wax content. The deposition of different wax compounds followed a co-ordinated pattern in birch leaves, but different compound groups varied in their responses to N fertilization and low VPD. Low VPD reduced the hydrophobicity of cuticular waxes, as demonstrated by lower alkane content and less hydrophobic flavonoid profile in low VPD than in high VPD. Reduced hydrophobicity of the wax layer is presumed to increase leaf wettability. Together with reduced trichome density in low VPD it may enhance the susceptibility of trees to fungal pathogens and herbivores. High N supply under low VPD reduced the effect of low VPD on the cuticular wax composition. Total fatty acid content and the expression of ß-amyrin synthase were lower under high N supply than under moderate N supply irrespective of VPD treatment. Nitrogen availability and decreasing VPD will modify leaf surface properties in silver birch and thereby affect tree defence against abiotic and biotic stress factors that emerge under climate change.
[Mh] Termos MeSH primário: Betula/fisiologia
Folhas de Planta/química
Tricomas/fisiologia
Pressão de Vapor
Ceras/química
[Mh] Termos MeSH secundário: Mudança Climática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waxes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/treephys/tpx045


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[PMID]:28847088
[Au] Autor:Wang QF; Niu LL; Jiao J; Guo N; Zang YP; Gai QY; Fu YJ
[Ad] Endereço:Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China.
[Ti] Título:Degradation of lignin in birch sawdust treated by a novel Myrothecium verrucaria coupled with ultrasound assistance.
[So] Source:Bioresour Technol;244(Pt 1):969-974, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Combined treatment of a novel fungal endophyte Myrothecium verrucaria coupled with ultrasound assistance was conducted to enhance lignin degradation in birch sawdust. The optimum treatment conditions were confirmed as the materials to liquid ratio 1:20, temperature 30°C, time 4days and pH 7, respectively. The results showed that the combined treatment led to the lignin degradation reaching 67.95±2.14%, while the lignin degradation were 45.50±2.12% and 13.75±0.66% with separate fungal treatment and ultrasound treatment, respectively. Moreover, SEM and FTIR analysis indicated that combined treatment significantly altered surface morphology and chemical structure of birch sawdust. The combined treatment greatly increased lignin removal during short time in mild environment. Therefore, these results demonstrated that the combined treatment of fungal endophyte coupled with ultrasound assistance has the high potential for the removal lignin in lignocellulose.
[Mh] Termos MeSH primário: Betula
Lignina
[Mh] Termos MeSH secundário: Celulose
Fungos
Madeira
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9004-34-6 (Cellulose); 9005-53-2 (Lignin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28787736
[Au] Autor:Scala E; Abeni D; Cecchi L; Guerra EC; Locanto M; Pirrotta L; Giani M; Asero R
[Ad] Endereço:Allergy Unit, IDI-IRCCS, Rome, Italy.
[Ti] Título:Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area.
[So] Source:Int Arch Allergy Immunol;173(3):138-146, 2017.
[Is] ISSN:1423-0097
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The order Fagales represents an important cause of tree-pollen allergy in northern countries. We investigated the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR-10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1). METHODS: A total of 526 PR-10-reactive subjects living in central and southern Italy were studied by ImmunoCAP-ISAC-112 microarray analysis. RESULTS: Overall, Bet v 1 reactivity was the most commonly (74%) observed among PR-10 proteins, but Cor a 1.0101 was the most prevalent in participants aged <6 years, and between 15 and 65 years. Overall, 26% of the PR-10-reactive persons were Bet v 1 negative, whilst 93.6% of the PR-10 polyreactive individuals were Bet v 1 positive. Among the 10 PR-10s evaluated, 100 combinations were recorded. The strongest association was observed between molecules with the highest sequence identities (Bet v 1 and Cor a 1.0101, Cor a 1.0401 or Aln g 1; Mal d 1 and Pru p 1). Bet v 1-, Cor a 1.0101-, and Aln g 1-specific IgE recognition was associated with respiratory symptoms, whilst Ara h 8, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1 were selectively linked to an oral allergic syndrome. CONCLUSIONS: Testing IgE reactivity to a panel of PR-10s in a birch-free area discloses peculiar relationships between clinical phenotypes and sensitization profiles, allowing the identification of novel cluster patterns.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Antígenos de Plantas/imunologia
Hipersensibilidade/sangue
Imunoglobulina E/sangue
Proteínas de Plantas/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Betula
Criança
Pré-Escolar
Feminino
Seres Humanos
Hipersensibilidade/diagnóstico
Imunoglobulina E/imunologia
Lactente
Itália
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Plant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1159/000477565


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[PMID]:28570890
[Au] Autor:Nadgórska-Socha A; Kandziora-Ciupa M; Trzesicki M; Barczyk G
[Ad] Endereço:University of Silesia, Department of Ecology, Bankowa 9, PL 40-007, Katowice, Poland. Electronic address: aleksandra.nadgorska-socha@us.edu.pl.
[Ti] Título:Air pollution tolerance index and heavy metal bioaccumulation in selected plant species from urban biotopes.
[So] Source:Chemosphere;183:471-482, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This research was carried out on plants Taraxacum officinale, Plantago lanceolata, Betula pendula and Robinia pseudoacacia growing in urban biotopes with different levels of heavy metal contamination in the city of Dabrowa Górnicza (southern Poland). Based on the pollution index, the highest heavy metal contamination was determined in the site 4 (connected with industry emitters) and 6 (high traffic). The metal accumulation index (MAI) values ranged within the biotopes in Dabrowa Górnicza between 7.3 and 20.6 for R. pseudoacacia, 4.71-23.1 for P. lanceolata, 4.68-28.1 for T. officinale and 10.5-27.2 for B. pendula. Increasing tendency in proline content in biotopes connected with high traffic was found in the leaves of investigated plants (except R. pseudoacacia). Similar tendency was observed for ascorbic acid content in the foliage of the plants as well as in T. officinalle in stands connected industrial emission. Non-protein thiols content increased especially in the leaves of R. pseudoacacia in biotopes with high traffic emissions as well as in T. officinale in stands connected with industry. The mean values of APTI (Air Pollution Tolerance Index) within the city of Dabrowa Górnicza for investigated plants were found in the following ascending order P. lanceolata < R. pseudoacacia < B. pendula < T. officinale. Among the investigated plants B. pendula and T. officinale may be postulated as appropriate plants in urban areas with considerable soil and air contamination, especially with heavy metals. The results indicate that species deemed tolerant according to APTI are suitable plants in barriers areas to combat atmospheric pollution.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental/métodos
Metais Pesados/análise
Folhas de Planta/metabolismo
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/metabolismo
Ácido Ascórbico/análise
Betula/química
Betula/metabolismo
Cidades
Metais Pesados/metabolismo
Modelos Biológicos
Folhas de Planta/química
Plantago/química
Plantago/metabolismo
Polônia
Robinia/química
Robinia/metabolismo
Estações do Ano
Poluentes do Solo/análise
Especificidade da Espécie
Taraxacum/química
Taraxacum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Metals, Heavy); 0 (Soil Pollutants); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


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[PMID]:28502093
[Au] Autor:Shalaby KH; Al Heialy S; Tsuchiya K; Farahnak S; McGovern TK; Risse PA; Suh WK; Qureshi ST; Martin JG
[Ad] Endereço:Department of Medicine, Meakins-Christie Laboratories, McGill University Health Centre Research Institute, McGill University, Montréal, QC, Canada.
[Ti] Título:The TLR4-TRIF pathway can protect against the development of experimental allergic asthma.
[So] Source:Immunology;152(1):138-149, 2017 Sep.
[Is] ISSN:1365-2567
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Toll-like receptor (TLR) adaptor proteins myeloid differentiating factor 88 (MyD88) and Toll, interleukin-1 receptor and resistance protein (TIR) domain-containing adaptor inducing interferon-ß (TRIF) comprise the two principal limbs of the TLR signalling network. We studied the role of these adaptors in the TLR4-dependent inhibition of allergic airway disease and induction of CD4 ICOS T cells by nasal application of Protollin™, a mucosal adjuvant composed of TLR2 and TLR4 agonists. Wild-type (WT), Trif or Myd88 mice were sensitized to birch pollen extract (BPEx), then received intranasal Protollin followed by consecutive BPEx challenges. Protollin's protection against allergic airway disease was TRIF-dependent and MyD88-independent. TRIF deficiency diminished the CD4 ICOS T-cell subsets in the lymph nodes draining the nasal mucosa, as well as their recruitment to the lungs. Overall, TRIF deficiency reduced the proportion of cervical lymph node and lung CD4 ICOS Foxp3 cells, in particular. Adoptive transfer of cervical lymph node cells supported a role for Protollin-induced CD4 ICOS cells in the TRIF-dependent inhibition of airway hyper-responsiveness. Hence, our data demonstrate that stimulation of the TLR4-TRIF pathway can protect against the development of allergic airway disease and that a TRIF-dependent adjuvant effect on CD4 ICOS T-cell responses may be a contributing mechanism.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transporte Vesicular/metabolismo
Asma/prevenção & controle
Linfócitos T CD4-Positivos/metabolismo
Pulmão/metabolismo
Rinite Alérgica Sazonal/prevenção & controle
Receptor 4 Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transporte Vesicular/genética
Proteínas Adaptadoras de Transporte Vesicular/imunologia
Transferência Adotiva
Animais
Antígenos de Plantas/imunologia
Asma/imunologia
Asma/metabolismo
Asma/fisiopatologia
Betula/imunologia
Hiper-Reatividade Brônquica/imunologia
Hiper-Reatividade Brônquica/metabolismo
Hiper-Reatividade Brônquica/fisiopatologia
Hiper-Reatividade Brônquica/prevenção & controle
Broncoconstrição
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD4-Positivos/transplante
Proliferação Celular
Quimiotaxia de Leucócito
Cisteína Endopeptidases/imunologia
Modelos Animais de Doenças
Combinação de Medicamentos
Feminino
Predisposição Genética para Doença
Proteína Coestimuladora de Linfócitos T Induzíveis/imunologia
Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo
Lipopolissacarídeos/imunologia
Pulmão/imunologia
Pulmão/fisiopatologia
Ativação Linfocitária
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fator 88 de Diferenciação Mieloide/genética
Fator 88 de Diferenciação Mieloide/metabolismo
Fenótipo
Pólen/imunologia
Rinite Alérgica Sazonal/imunologia
Rinite Alérgica Sazonal/metabolismo
Rinite Alérgica Sazonal/fisiopatologia
Transdução de Sinais
Fatores de Tempo
Receptor 4 Toll-Like/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Vesicular Transport); 0 (Antigens, Plant); 0 (Drug Combinations); 0 (Inducible T-Cell Co-Stimulator Protein); 0 (Lipopolysaccharides); 0 (Myd88 protein, mouse); 0 (Myeloid Differentiation Factor 88); 0 (Protollin); 0 (TICAM-1 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); EC 3.4.22.- (Cysteine Endopeptidases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1111/imm.12755


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[PMID]:28497679
[Au] Autor:Asero R
[Ad] Endereço:Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy. E-mail: r.asero@libero.it.
[Ti] Título:Disappearance of severe oral allergy syndrome following omalizumab treatment.
[So] Source:Eur Ann Allergy Clin Immunol;49(3):143-144, 2017 May.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Summary: The first case of disappearance of apple-induced oral allergy syndrome in a birch pollen-allergic patient following omalizumab treatment is reported. This observation in a case of type 2 food allergy suggests that omalizumab is potentially an effective preventive treatment for patients with severe, type 1 food allergies.
[Mh] Termos MeSH primário: Antialérgicos/uso terapêutico
Betula/imunologia
Hipersensibilidade Alimentar/tratamento farmacológico
Malus/imunologia
Omalizumab/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Testes Cutâneos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 2P471X1Z11 (Omalizumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28494455
[Au] Autor:Gellrich D; Eder K; San Nicoló M; Berghaus A; Gröger M
[Ad] Endereço:Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-Universität München, Munich, Germany.
[Ti] Título:The Clinical Impact of Bet v 6 in Birch Pollen-Sensitized Patients.
[So] Source:Int Arch Allergy Immunol;173(1):34-43, 2017.
[Is] ISSN:1423-0097
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bet v 6, a minor birch pollen allergen, is commercially available for allergen-specific IgE antibody testing. However, there is hardly any literature on the clinical impact of Bet v 6. The aim of the present study was to analyze if testing specific IgE against Bet v 6 can add valuable benefit to the standard diagnostics of birch pollen-sensitized patients, especially in patients with unknown sensitization-eliciting allergens. METHODS: Birch pollen-sensitized patients with missing IgE reactivity against Bet v 1, 2, and 4 were tested for specific IgE antibodies against Bet v 6. For comparison, an equal number of randomly selected patients with birch pollen sensitization, regardless of their individual sensitization patterns, were tested for specific anti-Bet v 6. RESULTS: Of 57 cases with missing reactivity against the standard birch pollen allergens, 2 patients were positive for Bet v 6. In the representative sample, 3 patients showed specific IgE against Bet v 6 - resulting in a total prevalence of 5%. None of the Bet v 6-positive patients showed allergic symptoms after exposure to birch pollen or an oral allergy syndrome. An increased prevalence of asthma and a higher degree of sensitization were the only distinctive clinical features in Bet v 6-positive patients. CONCLUSIONS: Among birch pollen-sensitized patients, the prevalence of specific IgE against Bet v 6 is low. Further, sensitization to Bet v 6, which shows characteristics of a panallergen, remains clinically silent. Therefore, determination of anti-Bet v 6 is not considered useful in the clinical routine.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Antígenos de Plantas/imunologia
Betula/imunologia
Proteínas de Plantas/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Masculino
Meia-Idade
Rinite Alérgica Sazonal/sangue
Rinite Alérgica Sazonal/imunologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Plant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1159/000470843


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[PMID]:28481341
[Au] Autor:Salojärvi J; Smolander OP; Nieminen K; Rajaraman S; Safronov O; Safdari P; Lamminmäki A; Immanen J; Lan T; Tanskanen J; Rastas P; Amiryousefi A; Jayaprakash B; Kammonen JI; Hagqvist R; Eswaran G; Ahonen VH; Serra JA; Asiegbu FO; de Dios Barajas-Lopez J; Blande D; Blokhina O; Blomster T; Broholm S; Brosché M; Cui F; Dardick C; Ehonen SE; Elomaa P; Escamez S; Fagerstedt KV; Fujii H; Gauthier A; Gollan PJ; Halimaa P; Heino PI; Himanen K; Hollender C; Kangasjärvi S; Kauppinen L; Kelleher CT; Kontunen-Soppela S; Koskinen JP; Kovalchuk A; Kärenlampi SO; Kärkönen AK; Lim KJ; Leppälä J; Macpherson L; Mikola J
[Ad] Endereço:Division of Plant Biology, Department of Biosciences, University of Helsinki, Helsinki, Finland.
[Ti] Título:Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch.
[So] Source:Nat Genet;49(6):904-912, 2017 Jun.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within 1 year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make birch an attractive model for forest biotechnology. We assembled and chromosomally anchored the nuclear genome of an inbred B. pendula individual. Gene duplicates from the paleohexaploid event were enriched for transcriptional regulation, whereas tandem duplicates were overrepresented by environmental responses. Population resequencing of 80 individuals showed effective population size crashes at major points of climatic upheaval. Selective sweeps were enriched among polyploid duplicates encoding key developmental and physiological triggering functions, suggesting that local adaptation has tuned the timing of and cross-talk between fundamental plant processes. Variation around the tightly-linked light response genes PHYC and FRS10 correlated with latitude and longitude and temperature, and with precipitation for PHYC. Similar associations characterized the growth-promoting cytokinin response regulator ARR1, and the wood development genes KAK and MED5A.
[Mh] Termos MeSH primário: Betula/genética
Genoma de Planta
Proteínas de Plantas/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adaptação Biológica/genética
Betula/fisiologia
Finlândia
Duplicação Gênica
Genética Populacional
Filogenia
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3862



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