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[PMID]: 28967570 [Au] Autor: Welden NA; Wolseley PA; Ashmore MR [Ad] Endereço: Stockholm Environment Institute, University of York, UK; Open University, Milton Keynes, UK. [Ti] Título: Citizen science identifies the effects of nitrogen deposition, climate and tree species on epiphytic lichens across the UK. [So] Source: Environ Pollut;232:80-89, 2018 Jan. [Is] ISSN: 1873-6424 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A national citizen survey quantified the abundance of epiphytic lichens that are known to be either sensitive or tolerant to nitrogen (N) deposition. Records were collected across the UK from over 10,000 individual trees of 22 deciduous species. Mean abundance of tolerant and sensitive lichens was related to mean N deposition rates and climatic variables at a 5 km scale, and the response of lichens was compared on the three most common trees (Quercus, Fraxinus and Acer) and by assigning all 22 tree species to three bark pH groups. The abundance of N-sensitive lichens on trunks decreased with increasing total N deposition, while that of N-tolerant lichens increased. The abundance of N-sensitive lichens on trunks was reduced close to a busy road, while the abundance of N-tolerant lichens increased. The abundance of N-tolerant lichen species on trunks was lower on Quercus and other low bark pH species, but the abundance of N-sensitive lichens was similar on different tree species. Lichen abundance relationships with total N deposition did not differ between tree species or bark pH groups. The response of N-sensitive lichens to reduced nitrogen was greater than to oxidised N, and the response of N-tolerant lichens was greater to oxidised N than to reduced N. There were differences in the response of N-sensitive and N-tolerant lichens to rainfall, humidity and temperature. Relationships with N deposition and climatic variables were similar for lichen presence on twigs as for lichen abundance on trunks, but N-sensitive lichens increased, rather than decreased, on twigs of Quercus/low bark pH species. The results demonstrate the unique power of citizen science to detect and quantify the air pollution impacts over a wide geographical range, and specifically to contribute to understanding of lichen responses to different chemical forms of N deposition, local pollution sources and bark chemistry. [Mh] Termos MeSH primário: Poluentes Atmosféricos/análise Monitoramento Ambiental/métodos Líquens/química Nitrogênio/análise [Mh] Termos MeSH secundário: Acer Poluição do Ar/estatística & dados numéricos Poluição Ambiental Líquens/fisiologia Quercus Árvores Reino Unido [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Air Pollutants); N762921K75 (Nitrogen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171003 [St] Status: MEDLINE

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[PMID]: 29282537 [Au] Autor: Jach R; Knutelski S; Uchman A; Hercman H; Dohnalik M [Ad] Endereço: Institute of Geological Sciences, Jagiellonian University, Gronostajowa 3a, 30-387, Kraków, Poland. renata.jach@uj.edu.pl. [Ti] Título: Subfossil markers of climate change during the Roman Warm Period of the late Holocene. [So] Source: Naturwissenschaften;105(1-2):6, 2017 Dec 27. [Is] ISSN: 1432-1904 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Abundant bog oak trunks occur in alluvial deposits of the Raba River in the village of Targowisko (southern Poland). Several of them contain galleries of the great capricorn beetle (Cerambyx cerdo L.). A well-preserved subfossil larva and pupa, as well as adults of this species, are concealed in some of the galleries. These galleries co-occur with boring galleries of other insects such as ship-timber beetles (Lymexylidae) and metallic wood borers (Buprestidae). A dry larva of a stag beetle (Lucanidae) and a mite (Acari) have been found in the C. cerdo galleries. Selected samples of the trunks and a sample of the C. cerdo larva were dated, using radiocarbon and dendrochronological methods, to the period from 45 BC to AD 554; one sample was dated to the period from 799 to 700 BC. Accumulation of the channel alluvia containing the bog oak trunks is synchronous with the Roman Warm Period (late antiquity/Early Mediaeval times). The most recent part of this period correlates with massive accumulations of fallen oak trunks noted from various river valleys in the Carpathian region and dated to AD 450-570. The results indicate that C. cerdo was more abundant within the study area during the Roman Warm Period than it is today. [Mh] Termos MeSH primário: Mudança Climática Coleópteros/fisiologia [Mh] Termos MeSH secundário: Animais Biomarcadores Ácaros/fisiologia Polônia Quercus Zonas Úmidas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171231 [Lr] Data última revisão: 171231 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171229 [St] Status: MEDLINE [do] DOI: 10.1007/s00114-017-1533-x

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[PMID]: 28973038 [Au] Autor: Fusaro L; Palma A; Salvatori E; Basile A; Maresca V; Asadi Karam E; Manes F [Ad] Endereço: Sapienza University of Rome, Department of Environmental Biology, Rome, Italy. [Ti] Título: Functional indicators of response mechanisms to nitrogen deposition, ozone, and their interaction in two Mediterranean tree species. [So] Source: PLoS One;12(10):e0185836, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The effects of nitrogen (N) deposition, tropospheric ozone (O3) and their interaction were investigated in two Mediterranean tree species, Fraxinus ornus L. (deciduous) and Quercus ilex L. (evergreen), having different leaf habits and resource use strategies. An experiment was conducted under controlled condition to analyse how nitrogen deposition affects the ecophysiological and biochemical traits, and to explore how the nitrogen-induced changes influence the response to O3. For both factors we selected realistic exposures (20 kg N ha-1 yr-1 and 80 ppb h for nitrogen and O3, respectively), in order to elucidate the mechanisms implemented by the plants. Nitrogen addition resulted in higher nitrogen concentration at the leaf level in F. ornus, whereas a slight increase was detected in Q. ilex. Nitrogen enhanced the maximum rate of assimilation and ribulose 1,5-bisphosphate regeneration in both species, whereas it influenced the light harvesting complex only in the deciduous F. ornus that was also affected by O3 (reduced assimilation rate and accelerated senescence-related processes). Conversely, Q. ilex developed an avoidance mechanism to cope with O3, confirming a substantial O3 tolerance of this species. Nitrogen seemed to ameliorate the harmful effects of O3 in F. ornus: the hypothesized mechanism of action involved the production of nitrogen oxide as the first antioxidant barrier, followed by enzymatic antioxidant response. In Q. ilex, the interaction was not detected on gas exchange and photosystem functionality; however, in this species, nitrogen might stimulate an alternative antioxidant response such as the emission of volatile organic compounds. Antioxidant enzyme activity was lower in plants treated with both O3 and nitrogen even though reactive oxygen species production did not differ between the treatments. [Mh] Termos MeSH primário: Fraxinus/fisiologia Nitrogênio/farmacologia Ozônio/farmacologia Fotossíntese/fisiologia Quercus/fisiologia [Mh] Termos MeSH secundário: Fraxinus/efeitos dos fármacos Fotossíntese/efeitos dos fármacos Folhas de Planta/efeitos dos fármacos Folhas de Planta/fisiologia Quercus/efeitos dos fármacos Espécies Reativas de Oxigênio/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Reactive Oxygen Species); 66H7ZZK23N (Ozone); N762921K75 (Nitrogen) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171019 [Lr] Data última revisão: 171019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171004 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0185836

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[PMID]: 28931057 [Au] Autor: Ungaro A; Pech N; Martin JF; McCairns RJS; Mévy JP; Chappaz R; Gilles A [Ad] Endereço: UMR 7263, Équipe Évolution Génome Environnement, Aix Marseille Université, CNRS, IRD, IMBE, Marseille, France. [Ti] Título: Challenges and advances for transcriptome assembly in non-model species. [So] Source: PLoS One;12(9):e0185020, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Analyses of high-throughput transcriptome sequences of non-model organisms are based on two main approaches: de novo assembly and genome-guided assembly using mapping to assign reads prior to assembly. Given the limits of mapping reads to a reference when it is highly divergent, as is frequently the case for non-model species, we evaluate whether using blastn would outperform mapping methods for read assignment in such situations (>15% divergence). We demonstrate its high performance by using simulated reads of lengths corresponding to those generated by the most common sequencing platforms, and over a realistic range of genetic divergence (0% to 30% divergence). Here we focus on gene identification and not on resolving the whole set of transcripts (i.e. the complete transcriptome). For simulated datasets, the transcriptome-guided assembly based on blastn recovers 94.8% of genes irrespective of read length at 0% divergence; however, assignment rate of reads is negatively correlated with both increasing divergence level and reducing read lengths. Nevertheless, we still observe 92.6% of recovered genes at 30% divergence irrespective of read length. This analysis also produces a categorization of genes relative to their assignment, and suggests guidelines for data processing prior to analyses of comparative transcriptomics and gene expression to minimize potential inferential bias associated with incorrect transcript assignment. We also compare the performances of de novo assembly alone vs in combination with a transcriptome-guided assembly based on blastn both via simulation and empirically, using data from a cyprinid fish species and from an oak species. For any simulated scenario, the transcriptome-guided assembly using blastn outperforms the de novo approach alone, including when the divergence level is beyond the reach of traditional mapping methods. Combining de novo assembly and a related reference transcriptome for read assignment also addresses the bias/error in contigs caused by the dependence on a related reference alone. Empirical data corroborate these findings when assembling transcriptomes from the two non-model organisms: Parachondrostoma toxostoma (fish) and Quercus pubescens (plant). For the fish species, out of the 31,944 genes known from D. rerio, the guided and de novo assemblies recover respectively 20,605 and 20,032 genes but the performance of the guided assembly approach is much higher for both the contiguity and completeness metrics. For the oak, out of the 29,971 genes known from Vitis vinifera, the transcriptome-guided and de novo assemblies display similar performance, but the new guided approach detects 16,326 genes where the de novo assembly only detects 9,385 genes. [Mh] Termos MeSH primário: Biologia Computacional/métodos Peixes/genética Perfilação da Expressão Gênica Quercus/genética Análise de Sequência de DNA/métodos Transcriptoma Peixe-Zebra/genética [Mh] Termos MeSH secundário: Animais Mapeamento de Sequências Contíguas Genoma Genômica Sequenciamento de Nucleotídeos em Larga Escala/métodos Modelos Estatísticos Anotação de Sequência Molecular [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170921 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0185020

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[PMID]: 28901768 [Au] Autor: Mazzeo G; Cimmino A; Masi M; Longhi G; Maddau L; Memo M; Evidente A; Abbate S [Ad] Endereço: Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia , Viale Europa 11, 25123 Brescia, Italy. [Ti] Título: Importance and Difficulties in the Use of Chiroptical Methods to Assign the Absolute Configuration of Natural Products: The Case of Phytotoxic Pyrones and Furanones Produced by Diplodia corticola. [So] Source: J Nat Prod;80(9):2406-2415, 2017 Sep 22. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: α-Pyrones and furanones are metabolites produced by Diplodia corticola, a pathogen of cork oak. Previously, the absolute configuration (AC) of diplopyrone was defined by chiroptical methods and Mosher's method. Using X-ray and chiroptical methods, the AC of sapinofuranone C was assigned, while that of the (4S,5S)-enantiomer of sapinofuranone B was established by enantioselective total synthesis. Diplofuranone A and diplobifuranylones A-C ACs are still unassigned. Here electronic and vibrational circular dichroism (ECD and VCD) and optical rotatory dispersion (ORD) spectra are reported and compared with density functional theory computations. The AC of the (4S,5S)-enantiomer of sapinofuranone B and sapinofuranone C is checked for completeness. The AC of diplobifuranylones A-C is assigned as (2S,2'S,5'S,6'S), (2S,2'R,5'S,6'R), and (2S,2'S,5'R,6'R), respectively, with the Mosher's method applied to define the absolute configuration of the carbinol stereogenic carbon. The AC assignment of sapinofuranones is problematic: while diplofuranone A is (4S,9R), sapinofuranones B and C are (4S,5S) according to ORD and VCD, but not to ECD. To eliminate these ambiguities, ECD and VCD spectra of a di-p-bromobenzoate derivative of sapinofuranone C are measured and calculated. For phytotoxicity studies, it is relevant that all six compounds share the S configuration for the stereogenic carbon atom of the lactone moiety. [Mh] Termos MeSH primário: Alcenos/química Produtos Biológicos/química Furanos/química Lactonas/química Pironas/química Quercus/química [Mh] Termos MeSH secundário: Alcenos/toxicidade Ascomicetos Dicroísmo Circular Furanos/toxicidade Lactonas/toxicidade Estrutura Molecular Dispersão Óptica Rotatória Pironas/toxicidade Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alkenes); 0 (Biological Products); 0 (Furans); 0 (Lactones); 0 (Pyrones); 0 (diplobifuranylone A); 0 (diplobifuranylone B); 0 (diplopyrone); 0 (sapinofuranone B) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.7b00119

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[PMID]: 28859145 [Au] Autor: Hermida-Carrera C; Fares MA; Fernández Á; Gil-Pelegrín E; Kapralov MV; Mir A; Molins A; Peguero-Pina JJ; Rocha J; Sancho-Knapik D; Galmés J [Ad] Endereço: Research Group on Plant Biology under Mediterranean Conditions, Universitat de les Illes Balears-INAGEA, Palma, Balearic Islands, Spain. [Ti] Título: Positively selected amino acid replacements within the RuBisCO enzyme of oak trees are associated with ecological adaptations. [So] Source: PLoS One;12(8):e0183970, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Phylogenetic analysis by maximum likelihood (PAML) has become the standard approach to study positive selection at the molecular level, but other methods may provide complementary ways to identify amino acid replacements associated with particular conditions. Here, we compare results of the decision tree (DT) model method with ones of PAML using the key photosynthetic enzyme RuBisCO as a model system to study molecular adaptation to particular ecological conditions in oaks (Quercus). We sequenced the chloroplast rbcL gene encoding RuBisCO large subunit in 158 Quercus species, covering about a third of the global genus diversity. It has been hypothesized that RuBisCO has evolved differentially depending on the environmental conditions and leaf traits governing internal gas diffusion patterns. Here, we show, using PAML, that amino acid replacements at the residue positions 95, 145, 251, 262 and 328 of the RuBisCO large subunit have been the subject of positive selection along particular Quercus lineages associated with the leaf traits and climate characteristics. In parallel, the DT model identified amino acid replacements at sites 95, 219, 262 and 328 being associated with the leaf traits and climate characteristics, exhibiting partial overlap with the results obtained using PAML. [Mh] Termos MeSH primário: Adaptação Fisiológica/genética Substituição de Aminoácidos Fotossíntese/genética Filogenia Quercus/genética Ribulose-Bifosfato Carboxilase/genética [Mh] Termos MeSH secundário: Cloroplastos/genética Cloroplastos/metabolismo Clima Árvores de Decisões Evolução Molecular Expressão Gênica Funções Verossimilhança Modelos Moleculares Mutação Folhas de Planta/genética Folhas de Planta/metabolismo Estrutura Secundária de Proteína Quercus/classificação Quercus/metabolismo Ribulose-Bifosfato Carboxilase/metabolismo Seleção Genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170901 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0183970

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[PMID]: 28846861 [Au] Autor: Jiménez-Morillo NT; Spangenberg JE; Miller AZ; Jordán A; Zavala LM; González-Vila FJ; González-Pérez JA [Ad] Endereço: IRNAS-CSIC, Av. Reina Mercedes, 10, 41012 Seville, Spain. [Ti] Título: Wildfire effects on lipid composition and hydrophobicity of bulk soil and soil size fractions under Quercus suber cover (SW-Spain). [So] Source: Environ Res;159:394-405, 2017 11. [Is] ISSN: 1096-0953 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Soil water repellency (hydrophobicity) prevents water from wetting or infiltrating soils, triggering changes in the ecosystems. Fire may develop, enhance or destroy hydrophobicity in previously wettable or water-repellent soils. Soil water repellency is mostly influenced by the quality and quantity of soil organic matter, particularly the lipid fraction. Here we report the results of a study on the effect of fire on the distribution of soil lipids and their role in the hydrophobicity grade of six particle size fractions (2-1, 1-0.5, 0.5-0.25, 0.25-0.1, 0.1-0.05 and <0.05mm) of an Arenosol under Quercus suber canopy at the Doñana National Park (SW-Spain). Hydrophobicity was determined using water drop penetration time test. Field emission scanning electron microscopy (FESEM) was used to assess the presence and morphology of the inorganic and organic soil components in the particle size fractions. Soil lipids were Soxhlet extracted with a dichloromethane-methanol mixture. Fatty acids (FAs) and neutral lipids were separated, derivatized, identified and quantified by gas chromatography/mass spectrometry and gas chromatography/flame ionization detection. The hydrophobicity values of soil samples and fractions were statistically different (P < 0.05), for both, the unburnt and burnt soils, and particle size fractions. All samples displayed a similar distribution of FAs, straight-chain saturated acids in the C -C range, and neutral lipids (n-alkan-1-ols, n-alkanes), only differing in their relative abundances. Among possible biogeochemical mechanisms responsible for the changes in soil lipids, the observed depletion of long chain FAs (C ) in the coarse fraction is best explained by thermal cracking caused by the heat of the fire. The enrichment of long chain FAs observed in other fractions suggests possible exogenous additions of charred, lipid-rich, material, like cork suberin or other plant-derived macromolecules (cutins). Principal component analysis was used to study the relationships between hydrophobicity with soil organic matter and its different components. Extractable organic matter (EOM) and specifically long chain FAs content were positively correlated to soil hydrophobicity. Therefore, the latter could be used as biomarkers surrogated to hydrophobicity in sandy soils. [Mh] Termos MeSH primário: Fogo Lipídeos/análise Quercus Solo/química [Mh] Termos MeSH secundário: Ecossistema Interações Hidrofóbicas e Hidrofílicas Quercus/química Espanha [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Lipids); 0 (Soil) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171120 [Lr] Data última revisão: 171120 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170829 [St] Status: MEDLINE

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[PMID]: 28774308 [Au] Autor: Ahmed M; Fatima H; Qasim M; Gul B; Ihsan-Ul-Haq [Ad] Endereço: Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. [Ti] Título: Polarity directed optimization of phytochemical and in vitro biological potential of an indigenous folklore: Quercus dilatata Lindl. ex Royle. [So] Source: BMC Complement Altern Med;17(1):386, 2017 Aug 03. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis. Brine shrimp lethality, SRB and MTT assays were employed to test cytotoxicity against Artemia salina and human cancer cell lines respectively. Antileishmanial activity was determined using standard MTT protocol. Glucose modulation was assessed by α-amylase inhibition assay while disc diffusion assay was used to establish protein kinase inhibitory and antifungal spectrum. RESULTS: Among 14 extracts of aerial parts, distilled water-acetone extract demonstrated maximum extract recovery (10.52% w/w), phenolic content (21.37 ± 0.21 µg GAE/mg dry weight (DW)), total antioxidant capacity (4.81 ± 0.98 µg AAE/mg DW) and reducing power potential (20.03 ± 2.4 µg/mg DW). On the other hand, Distilled water extract proficiently extracted flavonoid content (4.78 ± 0.51 µg QE/mg DW). RP-HPLC analysis revealed the presence of significant amounts of phenolic metabolites (0.049 to 15.336 µg/mg extract) including, pyrocatechol, gallic acid, catechin, chlorogenic acid, p-coumaric acid, ferulic acid and quercetin. Highest free radical scavenging capacity was found in Methanol-Ethyl acetate extract (IC 8.1 ± 0.5 µg/ml). In the brine shrimp toxicity assay, most of the tested extracts (57%) showed high cytotoxicity. Among these, Chloroform-Methanol extract had highest cytotoxicity against THP-1 cell line (IC 3.88 ± 0.53 µg/ml). About 50% of the extracts were found to be moderately antiproliferative against Hep G2 cell line. Methanol extract exhibited considerable protein kinase inhibitory activity against Streptomyces 85E strain (28 ± 0.35 mm bald phenotype at 100 µg/disc; MIC = 12.5 µg/ disc) while, Chloroform extract displayed maximum antidiabetic activity (α-amylase inhibition of 21.61 ± 1.53% at 200 µg/ml concentration). The highest antileishmanial potential was found in Ethyl acetate-Acetone extract (12.91 ± 0.02% at 100 µg/ml concentration), while, Q. dilatata extracts also showed a moderate antifungal activity. CONCLUSION: This study proposes that multiple-solvent system is a crucial variable to elucidate pharmacological potential of Q. dilatata and the results of the present findings prospects its potential as a resource for the discovery of novel anticancer, antidiabetic, antileishmanial and antioxidant agents. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia Antioxidantes/farmacologia Hipoglicemiantes/farmacologia Extratos Vegetais/farmacologia Inibidores de Proteínas Quinases/farmacologia Quercus/química Tripanossomicidas/farmacologia [Mh] Termos MeSH secundário: Antibacterianos/farmacologia Antifúngicos/farmacologia Antineoplásicos Fitogênicos/uso terapêutico Antioxidantes/uso terapêutico Flavonoides/isolamento & purificação Flavonoides/farmacologia Flavonoides/uso terapêutico Células Hep G2 Medicina Herbária Seres Humanos Leishmania/efeitos dos fármacos Medicina Tradicional Neoplasias/tratamento farmacológico Fenóis/isolamento & purificação Fenóis/farmacologia Fenóis/uso terapêutico Fitoterapia Componentes Aéreos da Planta Extratos Vegetais/química Extratos Vegetais/uso terapêutico Solventes Streptomyces/efeitos dos fármacos alfa-Amilases/antagonistas & inibidores [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Plant Extracts); 0 (Protein Kinase Inhibitors); 0 (Solvents); 0 (Trypanocidal Agents); EC 3.2.1.1 (alpha-Amylases) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170901 [Lr] Data última revisão: 170901 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170805 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-1894-x

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[PMID]: 28686301 [Au] Autor: Chaves I; Costa BV; Rodrigues AS; Bohn A; Miguel CM [Ad] Endereço: Instituto de Biologia Experimental e Tecnológica (iBET), Oeiras, Portugal. [Ti] Título: miRPursuit-a pipeline for automated analyses of small RNAs in model and nonmodel plants. [So] Source: FEBS Lett;591(15):2261-2268, 2017 Aug. [Is] ISSN: 1873-3468 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: miRPursuit is a pipeline developed for running end-to-end analyses of high-throughput small RNA (sRNA) sequence data in model and nonmodel plants, from raw data to identified and annotated conserved and novel sequences. It consists of a series of UNIX shell scripts, which connect open-source sRNA analysis software. The involved parameters can be combined with convenient workflow management by users without advanced computational skills. miRPursuit presents several advantages when compared to other tools, including the possibility of processing several sRNA libraries in parallel, thus easily allowing a comparison of the differences in sRNA read accumulation among sRNA libraries. We validate miRPursuit by using datasets from a model plant and discuss its performance with the analysis of sRNAs from non-model species. [Mh] Termos MeSH primário: Sequenciamento de Nucleotídeos em Larga Escala/métodos MicroRNAs/análise Quercus/genética RNA de Plantas/análise Software [Mh] Termos MeSH secundário: Automação Bases de Dados Genéticas Reprodutibilidade dos Testes [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (MicroRNAs); 0 (RNA, Plant) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170708 [St] Status: MEDLINE [do] DOI: 10.1002/1873-3468.12746

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[PMID]: 28640277 [Au] Autor: Ledford H [Ti] Título: Ancient oak's youthful genome surprises biologists. [So] Source: Nature;546(7659):460, 2017 06 19. [Is] ISSN: 1476-4687 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Evolução Molecular Genoma Quercus/genética [Pt] Tipo de publicação: NEWS; COMMENT [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171026 [Lr] Data última revisão: 171026 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170623 [St] Status: MEDLINE [do] DOI: 10.1038/546460a

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