Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.750.500.500 [Categoria DeCS]
Referências encontradas : 678 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 68 ir para página                         

  1 / 678 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29478642
[Au] Autor:Ning P; Liu S; Wang C; Li K; Sun X; Tang L; Liu G
[Ad] Endereço:Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
[Ti] Título:Adsorption-oxidation of hydrogen sulfide on Fe/walnut-shell activated carbon surface modified by NH -plasma.
[So] Source:J Environ Sci (China);64:216-226, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Walnut-shell activated carbon (WSAC) supported ferric oxide was modified by non-thermal plasma (NTP), and the removal efficiency for hydrogen sulfide over Fe/WSAC modified by dielectric barrier discharge (DBD) was significantly promoted. The sample modified for 10min and 6.8kV output (30V input voltage) maintained 100% H S conversion over a long reaction time of 390min. The surface properties of adsorbents modified by NTP under different conditions were evaluated by the methods of X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) analysis and in-situ Fourier transform infrared spectroscopy (FTIR), to help understand the effect of the NTP treatment. NTP treatment enhanced the adsorption capacity of Fe/WSAC, which could due to the formation of micro-pores with sizes of 0.4, 0.5 and 0.75nm. XPS revealed that chemisorbed oxygen changed into lattice oxygen after NTP treatment, and lattice oxygen is beneficial for H S oxidation. From the in-situ FTIR result, transformation of the reaction path on Fe/WSAC was observed after NTP modification. The research results indicate that NTP is an effective method to improve the surface properties of the Fe/WSAC catalyst for H S adsorption-oxidation.
[Mh] Termos MeSH primário: Amônia/química
Sulfeto de Hidrogênio/química
Ferro/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Carvão Vegetal/química
Juglans
Oxirredução
Gases em Plasma
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasma Gases); 16291-96-6 (Charcoal); 7664-41-7 (Ammonia); E1UOL152H7 (Iron); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


  2 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29311522
[Au] Autor:Matthäus B; Özcan MM; Juhaimi FA; Adiamo OQ; Alsawmahi ON; Ghafoor K; Babiker EE
[Ad] Endereço:Max Rubner-Institut (MRI) Bundesforschungsinstitut für Ernährung und Lebensmittel Institut für Sicherheit und Qualität bei GetreideSchützenberg.
[Ti] Título:Effect of the Harvest Time on Oil Yield, Fatty Acid, Tocopherol and Sterol Contents of Developing Almond and Walnut Kernels.
[So] Source:J Oleo Sci;67(1):39-45, 2018.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Oil content and bioactive properties of almond and walnut kernels were investigated in developing almond and walnut kernels at 10 days intervals. The oil contents of almond and walnuts after the first harvest (1.H) stage changed between 46.2% and 55.0% to 39.1% and 70.5%, respectively (p<0.05). Oleic acid contents of almond and walnut oils ranged from 71.98% (1.H) to 78.68% (5.H) and 10.51% (1.H) to 16.78% (2.H) depending on harvest (H) times, respectively (p<0.05). In addition, linolenic acid contents of walnut and almond oils were found between 62.35% and 67.78%, and 12.02% and 17.65%, respectively. The almond kernel oil after the first harvest stage contained 1.045, 1.058, 1.018, 0.995 and 0.819 mg/kg É‘-tocopherol, respectively. γ-Tocopherol contents of walnut oil changed between 1.364 (3.H) and 2.954 mg/kg (1.H). The ß-sitosterol contents of both almond and walnut oils were found between 1956.6 (5.H) and 2557.7 (1.H), and 1192.1 (3.H) and 4426.4 mg/kg (1.H). The study exhibited the presence of high percentage of oleic and linoleic for almond and walnut, respectively, and γ-tocopherol and ß-sitosterol.
[Mh] Termos MeSH primário: Produtos Agrícolas/química
Juglans/química
Ácidos Oleicos/análise
Óleos Vegetais/análise
Prunus dulcis/química
Sitosteroides/análise
Ácido alfa-Linolênico/análise
alfa-Tocoferol/análise
gama-Tocoferol/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Cromatografia Líquida de Alta Pressão
Óleos Vegetais/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oleic Acids); 0 (Plant Oils); 0 (Sitosterols); 0RBV727H71 (alpha-Linolenic Acid); 5LI01C78DD (gamma-sitosterol); 66YXD4DKO9 (almond oil); 8EF1Z1238F (gamma-Tocopherol); H4N855PNZ1 (alpha-Tocopherol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17162


  3 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29304036
[Au] Autor:Oren E; Klingeman W; Gazis R; Moulton J; Lambdin P; Coggeshall M; Hulcr J; Seybold SJ; Hadziabdic D
[Ad] Endereço:Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, United States of America.
[Ti] Título:A novel molecular toolkit for rapid detection of the pathogen and primary vector of thousand cankers disease.
[So] Source:PLoS One;13(1):e0185087, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thousand Cankers Disease (TCD) of Juglans and Pterocarya (Juglandaceae) involves a fungal pathogen, Geosmithia morbida, and a primary insect vector, Pityophthorus juglandis. TCD was described originally from dying Juglans nigra trees in the western United States (USA), but it was reported subsequently from the eastern USA and northern Italy. The disease is often difficult to diagnose due to the absence of symptoms or signs on the bark surface of the host. Furthermore, disease symptoms can be confused with those caused by other biotic and abiotic agents. Thus, there is a critical need for a method for rapid detection of the pathogen and vector of TCD. Using species-specific microsatellite DNA markers, we developed a molecular protocol for the detection of G. morbida and P. juglandis. To demonstrate the utility of the method for delineating TCD quarantine zones, we tested whether geographical occurrence of symptoms and signs of TCD was correlated with molecular evidence for the presence of the cryptic TCD organisms. A total of 1600 drill cores were taken from branch sections collected from three regions (n = 40 trees for each location): California-J. hindsii (heavy disease incidence); Tennessee-J. nigra (mild disease incidence); and outside the known TCD zone (Missouri-J. nigra, no record of the disease). California samples had the highest incidence of the TCD organisms (85%, 34/40). Tennessee had intermediate incidence (42.5%, 17/40), whereas neither organism was detected in samples from Missouri. The low cost molecular protocol developed here has a high degree of sensitivity and specificity, and it significantly reduces sample-processing time, making the protocol a powerful tool for rapid detection of TCD.
[Mh] Termos MeSH primário: Hypocreales/genética
Hypocreales/patogenicidade
Insetos Vetores/genética
Insetos Vetores/microbiologia
Juglans/microbiologia
Doenças das Plantas/microbiologia
Gorgulhos/genética
Gorgulhos/microbiologia
[Mh] Termos MeSH secundário: Animais
California
DNA Fúngico/genética
Técnicas Genéticas
Hypocreales/isolamento & purificação
Repetições de Microssatélites
Missouri
Especificidade da Espécie
Tennessee
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185087


  4 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29023476
[Au] Autor:Aradhya M; Velasco D; Ibrahimov Z; Toktoraliev B; Maghradze D; Musayev M; Bobokashvili Z; Preece JE
[Ad] Endereço:National Clonal Germplasm Repository, USDA-ARS, University of California Davis, Davis, California, United States of America.
[Ti] Título:Genetic and ecological insights into glacial refugia of walnut (Juglans regia L.).
[So] Source:PLoS One;12(10):e0185974, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The distribution and survival of trees during the last glacial maximum (LGM) has been of interest to paleoecologists, biogeographers, and geneticists. Ecological niche models that associate species occurrence and abundance with climatic variables are widely used to gain ecological and evolutionary insights and to predict species distributions over space and time. The present study deals with the glacial history of walnut to address questions related to past distributions through genetic analysis and ecological modeling of the present, LGM and Last Interglacial (LIG) periods. A maximum entropy method was used to project the current walnut distribution model on to the LGM (21-18 kyr BP) and LIG (130-116 kyr BP) climatic conditions. Model tuning identified the walnut data set filtered at 10 km spatial resolution as the best for modeling the current distribution and to hindcast past (LGM and LIG) distributions of walnut. The current distribution model predicted southern Caucasus, parts of West and Central Asia extending into South Asia encompassing northern Afghanistan, Pakistan, northwestern Himalayan region, and southwestern Tibet, as the favorable climatic niche matching the modern distribution of walnut. The hindcast of distributions suggested the occurrence of walnut during LGM was somewhat limited to southern latitudes from southern Caucasus, Central and South Asian regions extending into southwestern Tibet, northeastern India, Himalayan region of Sikkim and Bhutan, and southeastern China. Both CCSM and MIROC projections overlapped, except that MIROC projected a significant presence of walnut in the Balkan Peninsula during the LGM. In contrast, genetic analysis of the current walnut distribution suggested a much narrower area in northern Pakistan and the surrounding areas of Afghanistan, northwestern India, and southern Tajikistan as a plausible hotspot of diversity where walnut may have survived glaciations. Overall, the findings suggest that walnut perhaps survived the last glaciations in several refugia across a wide geographic area between 30° and 45° North latitude. However, humans probably played a significant role in the recent history and modern distribution of walnut.
[Mh] Termos MeSH primário: Variação Genética
Juglans/genética
Modelos Genéticos
[Mh] Termos MeSH secundário: Ásia
Ecologia
Genética Populacional
Juglans/fisiologia
Repetições de Microssatélites
Filogeografia
Polimorfismo Genético
Refúgio Biológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185974


  5 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28973569
[Au] Autor:Audley J; Klingeman WE; Mayfield A; Myers S; Taylor A
[Ad] Endereço:Department of Forestry Wildlife and Fisheries, University of Tennessee, 2506 Jacob Drive, Knoxville, TN 37996.
[Ti] Título:Walnut Twig Beetle (Coleoptera: Curculionidae: Scolytinae) Colonization of Eastern Black Walnut Nursery Trees.
[So] Source:J Insect Sci;17(3), 2017 May 01.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thousand cankers disease, caused by the invasive bark beetle Pityophthorus juglandis Blackman and an associated fungal pathogen Geosmithia morbida M.Kolarík, E. Freeland, C. Utley, N. Tisserat, currently threatens the health of eastern black walnut (Juglans nigra L.) in North America. Both the beetle and pathogen have expanded beyond their native range via transport of infested walnut wood. Geosmithia morbida can develop in seedlings following inoculation, but the ability of P. juglandis to colonize young, small diameter trees has not been investigated. This study assessed the beetle's colonization behavior on J. nigra nursery trees. Beetles were caged directly onto the stems of walnut seedlings from five nursery sources representing a range of basal stem diameter classes. Seedlings were also exposed to P. juglandis in a limited choice, field-based experiment comparing pheromone-baited and unbaited stems. When beetles were caged directly onto stems, they probed and attempted to colonize seedlings across the range of diameters and across sources tested, including stems as small as 0.5 cm in diameter. In the field experiment, beetles only attempted to colonize seedlings that were baited with a pheromone lure and appeared to prefer (though not statistically significant) the larger diameter trees. Despite several successful penetrations into the phloem, there was no evidence of successful progeny development within the young trees in either experiment. Further investigation is recommended to better elucidate the risk nursery stock poses as a pathway for thousand cankers disease causal organisms.
[Mh] Termos MeSH primário: Interações Hospedeiro-Parasita
Insetos Vetores/fisiologia
Juglans/parasitologia
Gorgulhos/fisiologia
[Mh] Termos MeSH secundário: Animais
Ascomicetos/fisiologia
Feminino
Herbivoria
Insetos Vetores/microbiologia
Juglans/microbiologia
Masculino
Doenças das Plantas
Gorgulhos/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1093/jisesa/iex046


  6 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28969623
[Au] Autor:Nasiry D; Khalatbary AR; Ahmadvand H; Talebpour Amiri F; Akbari E
[Ad] Endereço:Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
[Ti] Título:Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats.
[So] Source:BMC Complement Altern Med;17(1):476, 2017 Oct 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evidence that Juglans regia L. (GRL) leaf extract, a rich source of phenolic components, has hypoglycemic and antioxidative properties. This study aimed to determine the protective effects of Juglans regia L. leaf extract against streptozotocin-induced diabetic neuropathy in rat. METHODS: The DPN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose of streptozotocin (STZ). A subset of the STZ-induced diabetic rats intragastically administered with GRL leaf extract (200 mg/kg/day) before or after the onset of neuropathy, whereas other diabetic rats received only isotonic saline as the same volume of GRL leaf extract. To evaluate the effects of GRL leaf extract on the diabetic neuropathy various parameters, including histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with nociceptive and biochemical assessments. RESULTS: Degeneration of the sciatic nerves which was detected in the STZ-diabetic rats attenuated after GRL leaf extract administration. Greater caspase-3, COX-2, and iNOS expression could be detected in the STZ-diabetic rats, which were significantly attenuated after GRL leaf extract administration. Also, attenuation of lipid peroxidation and nociceptive response along with improved antioxidant status in the sciatic nerve of diabetic rats were detected after GRL leaf extract administration. In other word, GRL leaf extract ameliorated the behavioral and structural indices of diabetic neuropathy even after the onset of neuropathy, in addition to blood sugar reduction. CONCLUSION: Our results suggest that GRL leaf extract exert preventive and curative effects against STZ-induced diabetic neuropathy in rats which might be due to its antioxidant, anti-inflammatory, and antiapoptotic properties. Protection against neuropathy.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Neuropatias Diabéticas/metabolismo
Juglans/química
Nervos Periféricos/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Glicemia/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Neuropatias Diabéticas/induzido quimicamente
Hipoglicemiantes/farmacologia
Masculino
Nervos Periféricos/patologia
Extratos Vegetais/química
Folhas de Planta/química
Ratos
Ratos Sprague-Dawley
Estreptozocina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1983-x


  7 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28961948
[Au] Autor:Klingeman WE; Bray AM; Oliver JB; Ranger CM; Palmquist DE
[Ad] Endereço:Plant Sciences Department, The University of Tennessee, 2431 Joe Johnson Drive, 252 Ellington PSB, Knoxville, TN 37996.
[Ti] Título:Trap Style, Bait, and Height Deployments in Black Walnut Tree Canopies Help Inform Monitoring Strategies for Bark and Ambrosia Beetles (Coleoptera: Curculionidae: Scolytinae).
[So] Source:Environ Entomol;46(5):1120-1129, 2017 10 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Knowledge about which bark and ambrosia beetle species are active and at what heights in black walnut canopies is not well understood. Neither is the role of these beetles in spreading Thousand Cankers Disease. To assist with future planned research, which will assess the extent to which these beetle species are associated with Geosmithia morbida Kolarík, Freeland, Utley, and Tisserat (Ascomycota: Hypocreales: Bionectriaceae), experiments were undertaken to monitor bark and ambrosia beetles in urban landscapes and parks in Tennessee between 2011 and 2013. Within mature walnut tree canopies, sticky panel, modified soda bottle, and Lindgren traps were deployed at different heights, with and without ethanol as an attractant and with and without walnut stem sections, or in situ limbs that had been girdled or injection with ethanol to simulate stressed tree tissues. Bark and ambrosia beetle species (Coleoptera: Curculionidae: Scolytinae) collected in greatest abundance included Ambrosiodmus rubricollis (Eichhoff), Ambrosiophilus atratus (Eichhoff), Cnestus mutilatus (Blandford), Dryoxylon onoharaense (Murayama), Euwallacea validus (Eichhoff), Monarthrum fasciatum (Say), Monarthrum mali (Fitch), Xyleborinus saxesenii (Ratzeburg), Xyleborus affinis Eichhoff, Xyleborus ferrugineus (Fabricius), Xylosandrus crassiusculus (Motschulsky), and Xylosandrus germanus (Blandford). C. mutilatus, X. saxesenii, and X. crassiusculus were more active higher in trees than most other species and were strongly attracted to ethanol via all means of lure deployment. C. mutilatus, which were captured from April through October and increased in abundance across the 3-yr study, were most abundant in late May with a second activity period in late August.
[Mh] Termos MeSH primário: Controle de Insetos/instrumentação
Juglans
Gorgulhos
[Mh] Termos MeSH secundário: Animais
Etanol
Feminino
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx133


  8 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28831957
[Au] Autor:Bitok E; Jaceldo-Siegl K; Rajaram S; Serra-Mir M; Roth I; Feitas-Simoes T; Ros E; Sabaté J
[Ad] Endereço:1School of Public Health,Center for Nutrition, Lifestyle, and Disease Prevention,Loma Linda University,Loma Linda,CA 92350,USA.
[Ti] Título:Favourable nutrient intake and displacement with long-term walnut supplementation among elderly: results of a randomised trial.
[So] Source:Br J Nutr;118(3):201-209, 2017 Aug.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Older adults tend to require fewer energy content and higher levels of nutrients to promote and maintain optimal health. Regrettably, dietary variety and quality are known to decline with advancing age. We conducted a 2-year prospective, randomised, dietary intervention trial where we asked free-living elderly subjects (63-79 years) on self-selected habitual diets to incorporate walnuts daily into their diet (15 % energy). We then compared their nutrient intake with that of a similar group of concurrent participants on self-selected habitual diets but abstaining from walnut consumption (control). No recipes or advice on use of nuts were provided. Dietary intake was assessed by multiple unannounced 24-h telephone dietary recalls. On average, walnut supplement consumption was 43 g/d or 1171·5 kJ (281 kcal). The mean daily energy intake was 954 kJ (228 kcal) higher in the walnut group than in the control group (P<0·001). Compared with control, participants in the walnut group reported significantly higher intake of total protein, vegetable protein, total PUFA and n-3 and n-6 PUFA; and significantly lower intake of total carbohydrate, animal protein, SFA, and Na. An estimated 19 % of total energy and 25 % of total fat from other food sources was displaced. Displacement of MUFA and total PUFA was 21 and 16 %, respectively. Thus adding a daily supplement of walnuts to an ad libitum diet of older adults can induce favourable modifications to the nutrient profile in a way that addresses declining nutrient intake associated with aging.
[Mh] Termos MeSH primário: Envelhecimento
Dieta
Juglans
Nozes
[Mh] Termos MeSH secundário: Idoso
Índice de Massa Corporal
Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Ácidos Graxos/administração & dosagem
Ácidos Graxos Monoinsaturados/administração & dosagem
Ácidos Graxos Insaturados/administração & dosagem
Feminino
Dieta Saudável
Seres Humanos
Masculino
Rememoração Mental
Meia-Idade
Avaliação Nutricional
Estudos Prospectivos
Sódio na Dieta/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Unsaturated); 0 (Sodium, Dietary)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001957


  9 / 678 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28737396
[Au] Autor:Li Q; Deng AJ; Li L; Wu LQ; Ji M; Zhang HJ; Li ZH; Ma L; Zhang ZH; Chen XG; Qin HL
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
[Ti] Título:Azacyclo-indoles and Phenolics from the Flowers of Juglans regia.
[So] Source:J Nat Prod;80(8):2189-2198, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seven new azacyclo-indoles and phenolics and four known alkaloids were isolated from the flowers of Juglans regia. Spectroscopic and chromatographic data revealed that the structures of the new compounds are 5,6,11,12-tetrahydropyrrolo[1',2':1,2]azepino[4,5-b]indole-3-carbaldehyde (1), (±)-5,6,7,11c-tetrahydro-1H-indolizino[7,8-b]indol-3(2H)-one (2), (±)-9-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-2-carboxamide (3), 5-(ethoxymethyl)-1-(4-hydroxyphenethyl)-1H-pyrrole-2-carbaldehyde (4), (±)-5,8-dihydroxy-4-(1H-indol-3-yl)-3,4-dihydronaphthalen-1(2H)-one (5), (±)-4-(6-amino-9H-purin-9-yl)-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (6), and (±)-4-(6-amino-9H-purin-9-yl)-5-hydroxy-3,4-dihydronaphthalen-1(2H)-one (7). The five pairs of enantiomers were resolved, and the absolute configurations of the enantiomers were assigned via electronic circular dichroism data. Compound 1 exhibited significant in vitro growth inhibition against the HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cancer cell lines, with IC values of 2.87, 1.87, 2.28, 2.86, and 0.96 µM, respectively, and low cytotoxicity toward normal IEC-6 cells, with a 79.6% survival rate at a 10 µM concentration.
[Mh] Termos MeSH primário: Aldeídos/isolamento & purificação
Aldeídos/farmacologia
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Azepinas/isolamento & purificação
Azepinas/farmacologia
Flores/química
Indóis/isolamento & purificação
Indóis/farmacologia
Juglans/química
Fenóis/química
[Mh] Termos MeSH secundário: Aldeídos/química
Alcaloides/química
Azepinas/química
Linhagem Celular Tumoral
Dicroísmo Circular
Seres Humanos
Indóis/química
Concentração Inibidora 50
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5,6,11,12-tetrahydropyrrolo(1',2'-1,2)azepino(4,5-b)indole-3-carbaldehyde); 0 (Aldehydes); 0 (Alkaloids); 0 (Azepines); 0 (Indoles); 0 (Phenols)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00887


  10 / 678 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28712479
[Au] Autor:Meshkini A; Tahmasbi M
[Ad] Endereço:Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: a.meshkini@um.ac.ir.
[Ti] Título:Antiplatelet Aggregation Activity of Walnut Hull Extract via Suppression of Reactive Oxygen Species Generation and Caspase Activation.
[So] Source:J Acupunct Meridian Stud;10(3):193-203, 2017 Jun.
[Is] ISSN:2093-8152
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Walnut hull (wal hull) is an agricultural by-product that is widely used in traditional medicine for alleviating pain and treating skin diseases, however, recently it has gained much attention in modern pharmacology due to its antioxidant properties. The current study was aimed to determine the total phenolic, flavonoid, and tannin content of Persian wal hull extract and evaluate its biological effects on platelet function. Experimental data showed that acetone extract of wal hulls has a high content of polyphenolic compounds and antioxidant properties. The analytical study of crude extract by gas chromatography-mass spectrometry demonstrated different types of high- and low-molecular-weight compounds that are basically and biologically important. Moreover, an in vitro study revealed that wal hull extract at a concentration of 50 µg/mL inhibited thrombin-induced platelet aggregation and protein secretion by 50%, without any cytotoxic effects on platelets. The examined extract suppressed reactive oxygen species generation and also caspase activation in thrombin-stimulated platelets. Identically, N-acetylcysteine inhibited the increase of reactive oxygen species level induced by thrombin in platelets, and supported a link between cellular redox status and caspase activation in activated platelets. Presumably, the antiplatelet activity of wal hull extract is related to its polyphenolic compounds and their antioxidant properties. Therefore, wal hulls can be considered as a candidate for thrombotic disorders.
[Mh] Termos MeSH primário: Antioxidantes/química
Caspases/metabolismo
Flavonoides/farmacologia
Juglans/química
Inibidores da Agregação de Plaquetas/química
Polifenóis/farmacologia
Espécies Reativas de Oxigênio/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adulto
Antioxidantes/farmacologia
Plaquetas/efeitos dos fármacos
Ativação Enzimática/efeitos dos fármacos
Flavonoides/química
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Irã (Geográfico)
Peroxidação de Lipídeos/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Agregação Plaquetária/efeitos dos fármacos
Inibidores da Agregação de Plaquetas/farmacologia
Polifenóis/química
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Platelet Aggregation Inhibitors); 0 (Polyphenols); 0 (Reactive Oxygen Species); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE



página 1 de 68 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde