Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937 [Categoria DeCS]
Referências encontradas : 1333 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 134 ir para página                         

  1 / 1333 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28500929
[Au] Autor:Rengifo Carrillo M; Mitaine-Offer AC; Miyamoto T; Tanaka C; Pouységu L; Quideau S; Rojas LB; Rosquete Porcar C; Lacaille-Dubois MA
[Ad] Endereço:Laboratoire de Pharmacognosie, PEPITE EA 4267, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, 7, Bd Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France; Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101, Venezuel
[Ti] Título:Oleanane-type glycosides from Pittosporum tenuifolium "variegatum" and P. tenuifolium "gold star".
[So] Source:Phytochemistry;140:166-173, 2017 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The phytochemical study of two cultivars of Pittosporum tenuifolium Banks & Sol. ex Gaertn, "variegatum" and "gold star", led to the isolation of eight oleanane-type glycosides: seven previously undescribed and a known one. Their aglycons are oxygenated oleanane derivatives as barringtogenol C, camelliagenin A, hederagenin, and 22α-hydroxyoleanolic acid. Their structures were established by 2D NMR spectroscopic techniques and mass spectrometry as 3-O-ß-D-galactopyranosyl-(1 â†’ 2)-[α-L-arabinopyranosyl-(1 â†’ 3)]-ß-D-glucuronopyranosyl-21-O-angeloyl-22-O-acetylbarringtogenol C, 3-O-ß-D-galactopyranosyl-(1 â†’ 2)-[α-L-arabinopyranosyl-(1 â†’ 3)]-ß-D-glucuronopyranosyl-21,22-di-O-angeloylbarringtogenol C, 3-O-ß-D-galactopyranosyl-(1 â†’ 2)-[α-L-arabinopyranosyl-(1 â†’ 3)]-ß-D-glucuronopyranosyl-22-O-angeloylcamelliagenin A, 3-O-ß-D-glucopyranosyl-(1 â†’ 2)-[ß-D-glucopyranosyl-(1 â†’ 6)]-ß-D-glucopyranosyl-22-O-[(6-O-acetyl)-ß-D-glucopyranosyl]camelliagenin A, 3-O-ß-D-galactopyranosyl-(1 â†’ 2)-[α-L-arabinofuranosyl-(1 â†’ 4)]-ß-D-glucuronopyranosylhederagenin 28-O-ß-D-glucopyranosyl ester, 3-O-α-L-arabinofuranosyl-(1 â†’ 4)-ß-D-glucuronopyranosylhederagenin 28-O-ß-D-glucopyranosyl ester, 3-O-ß-D-galactopyranosyl-(1 â†’ 2)-[α-L-arabinofuranosyl-(1 â†’ 4)]-ß-D-glucuronopyranosyl-22α-hydroxyoleanolic acid 28-O-ß-D-glucopyranosyl ester, and the known ilexoside XLIX. These results represent a significative contribution to the chemotaxonomy of the genus Pittosporum, highlighting hederagenin-type saponins as chemotaxonomic markers of P. tenuifolium cultivars.
[Mh] Termos MeSH primário: Glicosídeos/química
Ácido Oleanólico/análogos & derivados
Rosales/química
[Mh] Termos MeSH secundário: Glicosídeos/isolamento & purificação
Estrutura Molecular
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Extratos Vegetais/química
Saponinas/química
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts); 0 (Saponins); 0 (oleanane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


  2 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27903256
[Au] Autor:Daïnou K; Blanc-Jolivet C; Degen B; Kimani P; Ndiade-Bourobou D; Donkpegan AS; Tosso F; Kaymak E; Bourland N; Doucet JL; Hardy OJ
[Ad] Endereço:Nature + asbl / TERRA Research Centre, Central African Forests, Gembloux Agro-Bio Tech, University of Liege, Passage des Déportés 2, 5030, Gembloux, Belgium. k.dainou@natureplus.be.
[Ti] Título:Revealing hidden species diversity in closely related species using nuclear SNPs, SSRs and DNA sequences - a case study in the tree genus Milicia.
[So] Source:BMC Evol Biol;16(1):259, 2016 Dec 01.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Species delimitation in closely related plant taxa can be challenging because (i) reproductive barriers are not always congruent with morphological differentiation, (ii) use of plastid sequences might lead to misinterpretation, (iii) rare species might not be sampled. We revisited molecular-based species delimitation in the African genus Milicia, currently divided into M. regia (West Africa) and M. excelsa (from West to East Africa). We used 435 samples collected in West, Central and East Africa. We genotyped SNP and SSR loci to identify genetic clusters, and sequenced two plastid regions (psbA-trnH, trnC-ycf6) and a nuclear gene (At103) to confirm species' divergence and compare species delimitation methods. We also examined whether ecological niche differentiation was congruent with sampled genetic structure. RESULTS: West African M. regia, West African and East African M. excelsa samples constituted three well distinct genetic clusters according to SNPs and SSRs. In Central Africa, two genetic clusters were consistently inferred by both types of markers, while a few scattered samples, sympatric with the preceding clusters but exhibiting leaf traits of M. regia, were grouped with the West African M. regia cluster based on SNPs or formed a distinct cluster based on SSRs. SSR results were confirmed by sequence data from the nuclear region At103 which revealed three distinct 'Fields For Recombination' corresponding to (i) West African M. regia, (ii) Central African samples with leaf traits of M. regia, and (iii) all M. excelsa samples. None of the plastid sequences provide indication of distinct clades of the three species-like units. Niche modelling techniques yielded a significant correlation between niche overlap and genetic distance. CONCLUSIONS: Our genetic data suggest that three species of Milicia could be recognized. It is surprising that the occurrence of two species in Central Africa was not reported for this well-known timber tree. Globally, our work highlights the importance of collecting samples in a systematic way and the need for combining different nuclear markers when dealing with species complexes. Recognizing cryptic species is particularly crucial for economically exploited species because some hidden taxa might actually be endangered as they are merged with more abundant species.
[Mh] Termos MeSH primário: DNA de Plantas
Repetições de Microssatélites
Polimorfismo de Nucleotídeo Único
Rosales/genética
Árvores/genética
[Mh] Termos MeSH secundário: África Central
África Oriental
África Ocidental
Estruturas Genéticas
Genótipo
Família Multigênica
Filogenia
Rosales/classificação
Análise de Sequência de DNA
Especificidade da Espécie
Simpatria
Árvores/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


  3 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27434060
[Au] Autor:Thakur J; Dwivedi MD; Sourabh P; Uniyal PL; Pandey AK
[Ad] Endereço:Department of Botany, University of Delhi, Delhi, India.
[Ti] Título:Genetic Homogeneity Revealed Using SCoT, ISSR and RAPD Markers in Micropropagated Pittosporum eriocarpum Royle- An Endemic and Endangered Medicinal Plant.
[So] Source:PLoS One;11(7):e0159050, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pittosporum eriocarpum Royle, a medicinally important taxon, is endemic to Uttarakhand region of Himalaya. It has become endangered due to over-collection and the loss of habitats. As raising plants through seeds in this plant is problematic, a reliable protocol for micropropagation using nodal explants has been developed. High shoot regeneration (95%) occurred in MS medium augmented with BA 0.4mg/l in combination IBA 0.6mg/l. In vitro regenerated shoots were rooted in MS medium supplemented with three auxins, of which 0.6 mg/l indole butyric acid proved to be the best for rooting (90%) with maximum number of roots per shoot. Thereafter, rooted plants were hardened and nearly 73% of rooted shoots were successfully acclimatized and established in the field. Start codon targeted (SCoT), inter simple sequence repeats (ISSR) and random amplified polymorphic DNA (RAPD) markers were used to validate the genetic homogeneity amongst nine in vitro raised plantlets with mother plant. DNA fingerprints of in vitro regenerated plantlets displayed monomorphic bands similar to mother plant, indicating homogeneity among the micropropagated plants with donor mother plant. The similarity values were calculated based on SCoT, ISSR and RAPD profiles which ranged from 0.89 to 1.00, 0.91 to 1.00 and 0.95 to 1.00 respectively. The dendrograms generated through Unweighted Pair Group Method with arithmetic mean (UPGMA) analysis revealed 97% similarity amongst micropropagated plants with donor mother plant, thus confirming genetic homogeneity of micropropagated clones. This is the first report on micropropagation and genetic homogeneity assessment of P. eriocarpum. The protocol would be useful for the conservation and large scale production of P. eriocarpum to meet the demand for medicinal formulations and also for the re-introduction of in vitro grown plants in the suitable natural habitats to restore the populations.
[Mh] Termos MeSH primário: Espécies em Perigo de Extinção
Plantas Medicinais/genética
Técnica de Amplificação ao Acaso de DNA Polimórfico/métodos
Rosales/genética
[Mh] Termos MeSH secundário: Códon de Iniciação/genética
Impressões Digitais de DNA
Ácidos Indolacéticos/metabolismo
Repetições de Microssatélites/genética
Sementes/genética
Sementes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Initiator); 0 (Indoleacetic Acids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0159050


  4 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27336837
[Au] Autor:Elansary HO; Skalicka-Wozniak K; King IW
[Ad] Endereço:Biodiversity Institute of Ontario, University of Guelph, Guelph, ON N1G 2W1, Canada; Department of Floriculture, Ornamental Horticulture and Garden Design, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt. Electronic address: hosammail2003@yahoo.com.
[Ti] Título:Enhancing stress growth traits as well as phytochemical and antioxidant contents of Spiraea and Pittosporum under seaweed extract treatments.
[So] Source:Plant Physiol Biochem;105:310-320, 2016 Aug.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Seaweed extracts (SWE) might play an important role in enhancing growth and phytochemical composition of medicinal shrubs. In this study, we investigate the morphological, physiological and biochemical effects of irrigation levels (100% and 50% of the evapotranspiration rate) coupled with a weekly treatment of SWE of Ascophyllum nodosum at 5 and 7 mL L(-1) as a soil drench or foliar spray on Spiraea nipponica "Snowmound" and Pittosporum eugenioides "Variegatum" grown in containers under controlled greenhouse conditions. In addition, the phenolic and flavonoid content, antioxidant capacity and lipid peroxidation in both plant species was largely enhanced while the proline accumulation was reduced. After 8 weeks of treatments, drought condition reduced plant vegetative growth and gas exchange, as well as leaf water potential, but increased the phenolic and flavonoid contents in leaves, their antioxidant capacities and proline content. The application of SWE enhanced the performance of both species during mild drought conditions by means of increasing leaf number and area, dry weights, plant height, gas exchange and leaf water potential. The maximum vegetative growth, physiological performance and phytochemical composition of both species was achieved using the drench SWE treatments (5 and 7 mL L(-1)) in moderate drought conditions, which improved the plant water status, stomatal conductance, and photosynthetic rate. SWE enhanced plant growth and the phytochemical composition and antioxidant capacity of plant leaves of both species during moderate drought conditions.
[Mh] Termos MeSH primário: Antioxidantes/análise
Compostos Fitoquímicos/análise
Característica Quantitativa Herdável
Rosales/crescimento & desenvolvimento
Alga Marinha/química
Spiraea/crescimento & desenvolvimento
Estresse Fisiológico
[Mh] Termos MeSH secundário: Análise de Variância
Biomassa
Peroxidação de Lipídeos
Folhas de Planta/anatomia & histologia
Prolina/metabolismo
Rosales/anatomia & histologia
Rosales/metabolismo
Spiraea/anatomia & histologia
Spiraea/metabolismo
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phytochemicals); 059QF0KO0R (Water); 9DLQ4CIU6V (Proline)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE


  5 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27130641
[Au] Autor:Wandji BA; Tatsinkou Bomba FD; Awouafack MD; Nkeng-Efouet PA; Kamanyi A; Nguelefack TB
[Ad] Endereço:Laboratory of Animal Physiology and Phytopharmacology, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
[So] Source:J Ethnopharmacol;187:224-31, 2016 Jul 01.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Pittosporum mannii (Pittosporaceae) is used in Africa traditional medicine to treat various ailments including pain and inflammation. AIM OF THE STUDY: The present work was undertaken to evaluate the antinociceptive effects of the aqueous (AEPM) and methanol (MEPM) extracts from the leaves of Pittosporum mannii. METHODS: High performance liquid chromatography coupled with mass spectrometry (LCMS) was used for the phytochemical analysis of AEPM prepared as decoction and MEPM prepared as cold maceration. The in vitro cytotoxicity of AEPM and MEPM were evaluated on Artemia salina larvae. AEPM and MEPM antinociceptive effects were evaluated at the doses of 35, 75, 150 and 300mg/kg given orally, against pain induced by acetic acid, formalin, hot plate, capsaicin and glutamate. The rota rod test was also performed at the same doses. To determine the mechanism of action of these extracts, their antinociceptive effects were tested in animals pretreated with yohimbine (α2-adrenergic antagonist), atropine (muscarinic antagonist) or naloxone (an opioids antagonist). RESULT: The LCMS analysis showed that both extracts contain pittovidoside and 1-O-rhamnopyranosyl-23-acetoxyimberbic acid 29-methyl ester, the aqueous extract being more concentrated. Oral administration of both extracts significantly reduced pain symptoms induced by acetic acid, formalin, capsaicin, glutamate and hot plate. The antinociceptive effect of AEPM was significantly inhibited by yohimbine, atropine and naloxone while these inhibitors tend to potentiate the activity of MEPM. Both extracts have no effect on Rota rod test. AEPM and MEPM showed respective LC50 of 2.44 and 0.70mg/ml on Artemia larvae and were therefore, considered non-toxic. CONCLUSION: These results indicate that AEPM and MEPM possesses analgesic effects with different mechanism of action. Although effects of both extracts may involve TRPV1 receptors and glutamatergic pathway, AEPM may in addition, interact with alpha-adrenergic, muscarinic and opioidergic pathways that are not involve in the effects of MEPM.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Dor/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Rosales
[Mh] Termos MeSH secundário: Ácido Acético
Analgésicos/química
Analgésicos/toxicidade
Animais
Artemia/efeitos dos fármacos
Capsaicina
Feminino
Formaldeído
Ácido Glutâmico
Temperatura Alta
Larva/efeitos dos fármacos
Dose Letal Mediana
Masculino
Metanol/química
Camundongos
Atividade Motora/efeitos dos fármacos
Dor/etiologia
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/uso terapêutico
Compostos Fitoquímicos/toxicidade
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Folhas de Planta/química
Teste de Desempenho do Rota-Rod
Solventes/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); 1HG84L3525 (Formaldehyde); 3KX376GY7L (Glutamic Acid); Q40Q9N063P (Acetic Acid); S07O44R1ZM (Capsaicin); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE


  6 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26978036
[Au] Autor:Kaewkla O; Franco CM
[Ad] Endereço:1​ Department of Biology, Faculty of Science, Mahasarakham University, Maha Sarakham Province 44150, Thailand 2​ Department of Medical Biotechnology, School of Medicine, Flinders University, Bedford Park, SA 5042, Australia.
[Ti] Título:Kribbella pittospori sp. nov., an endophytic actinobacterium isolated from the surface-sterilized stem of an Australian native apricot tree, Pittosporum angustifolium.
[So] Source:Int J Syst Evol Microbiol;66(6):2284-90, 2016 Jun.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An endophytic actinobacterium, strain PIP 158T, was isolated from the stem of a native apricot tree (Pittosporum angustifolium) collected from the grounds of Flinders University, Adelaide, Australia. As a result of a polyphasic taxonomic study, this strain was identified as a member of the genus Kribbella. This strain was a Gram-stain-positive, aerobic actinobacterium with well-developed substrate mycelia which were non-motile and with hyphae fragmenting into short to elongated rod-like elements. Phylogenetic evaluation based on 16S rRNA gene sequence analysis placed this isolate in the family Nocardioidaceae, being most closely related to Kribbella sandramycini ATCC 39419T and Kribbella albertanoniae BC640T which share a similarity of 99. 26 and 99.18 % with Kribbella hippodromi S1.4T, respectively. Chemotaxonomic data including cell-wall components, major menaquinones and major fatty acids confirmed the affiliation of strain PIP 158T to the genus Kribbella. The results of the phylogenetic analysis, including physiological and biochemical studies in combination with DNA-DNA hybridization, allowed the genotypic and phenotypic differentiation of strain PIP 158T from the closest related species with validly published names. The name proposed for the novel species is Kribbella pittospori sp. nov. The type strain is PIP 158T (=DSM 23717T=NRRL B-24813T).
[Mh] Termos MeSH primário: Actinomycetales/classificação
Filogenia
Caules de Planta/microbiologia
Rosales/microbiologia
[Mh] Termos MeSH secundário: Actinomycetales/genética
Actinomycetales/isolamento & purificação
Austrália
Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Hibridização de Ácido Nucleico
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001023


  7 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26240190
[Au] Autor:Park JS; Kim IS; Shaheed Ur Rehman; Na CS; Yoo HH
[Ad] Endereço:Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea.
[Ti] Título:HPLC Determination of Bioactive Flavonoids in Hovenia dulcis Fruit Extracts.
[So] Source:J Chromatogr Sci;54(2):130-5, 2016 Feb.
[Is] ISSN:1945-239X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple, accurate and reproducible reversed-phase liquid chromatographic method was developed for qualitative and quantitative determination of four bioactive flavonoids (ampelopsin, taxifolin, myricetin and quercetin) from the fruit-stalk extract of Hovenia dulcis Thunb. Chromatographic separation was performed on a C18 column (4.6 × 150 mm, 3.5 µm) with mobile phase consisting of 0.1% acetic acid and 100% acetonitrile at a flow rate of 1.0 mL/min. The analysis was performed using a diode array detector at 365 nm. The method was validated in terms of selectivity, linearity, accuracy, precision and recovery. Good linearity was observed over the investigated concentration range (10-500 µg/mL), with correlation coefficient values greater than 0.99. The intra- and inter-day precisions over the concentration range were <3.91% (relative standard deviation), and the accuracy was between 91.57 and 106.66%. The mean recovery for all the analytes was 100.87%. This method was successfully applied in the quality assessment of bioactive flavonoids in the fruit-stalk extract of H. dulcis.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Flavonoides/análise
Extratos Vegetais/análise
Rosales/química
[Mh] Termos MeSH secundário: Frutas/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150805
[St] Status:MEDLINE
[do] DOI:10.1093/chromsci/bmv114


  8 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26363280
[Au] Autor:El Dib RA; Eskander J; Mohamed MA; Mohammed NM
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, 11795 Cairo, Egypt; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. Electronic address: reldib@yahoo.com.
[Ti] Título:Two new triterpenoid estersaponins and biological activities of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton leaves.
[So] Source:Fitoterapia;106:272-9, 2015 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS analysis. The investigated 80% aqueous methanol extract showed significant dose dependent inhibition of acetic acid induced abdominal writhing in mice. The n-butanol fraction exerted moderate antimicrobial activity against Staphylococcus aureus and Escherichia coli. In addition, it showed in vitro antioxidant activity with IC50 value (7.3 µg/ml) lower than that of the positive control ascorbic acid (11.2 µg/ml), using DPPH free radical scavenging activity method. Evaluation of its in vitro cytotoxicity showed strong activity against breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and colon carcinoma (HCT) cell lines.
[Mh] Termos MeSH primário: Flavonoides/farmacologia
Extratos Vegetais/farmacologia
Rosales/química
Saponinas/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Escherichia coli/efeitos dos fármacos
Flavonoides/isolamento & purificação
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Masculino
Camundongos
Estrutura Molecular
Folhas de Planta/química
Saponinas/isolamento & purificação
Staphylococcus aureus/efeitos dos fármacos
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151009
[Lr] Data última revisão:
151009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150913
[St] Status:MEDLINE


  9 / 1333 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:26201219
[Au] Autor:Vasfilov SP
[Ti] Título:[Influence of photosynthetic parameters on leaf longevity].
[So] Source:Zh Obshch Biol;76(3):225-43, 2015 May-Jun.
[Is] ISSN:0044-4596
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Higher plants show a wide range of leaf lifespan (LL) variability. LL is calculated as a sum of functional LL(f) (corresponding to the time of active photosynthesis and CO2 accumulation in the leaf) and nonfunctional LL(n) (the time of photosynthetic activity absence). For evergreen species of boreal zones, LL(n) corresponds to the period of winter rest. Photosynthetic potential of leaf (PPL), interpreted as the maximum possible amount of CO2 that can be fixed during its life, can be estimated on the basis of maximum photosynthesis rate (P(a)) dynamics during LL(f); the maximum (P(a max)) being achieved in mature leaf. Photosynthetic potential depends on LL(f) more strongly than on P(a max). The PPL/LL(f) ratio is indicative of the rate of PPL realization over leaf lifespan. As LL(f) shows strong positive correlation with LL, the latter parameter can also characterize the rate of PPL realization. Long LL(f) in evergreen species provides higher PPL, which is advantageous by comparison with deciduous ones. In evergreen species, the PPL itself is realized slower than in deciduous ones. The increase in LL(f) and LL is accompanied by the increase in leaf constructional cost (LCC(a)) as well as the decrease in photosynthesis rate. At that, photosynthesis rate per unit of dry weight (P(m)) decreases much faster than that per unit of leaf area (P(a)). Apparently, when considering dry leaf weight, the apoplast share seems to be much higher in long-living leaves of evergreen species than in short-living leaves of deciduous species. The leaf payback (LP) may be stabilized by unidirectional shifts in PPL and LCC(a). Species with short/long LL(f) and high/low PPL realization rate are typical for early/late succession stages and for habitats with the environmental conditions favorable/adverse for photosynthesis and growth. If the conditions for photosynthesis and growth are favorable, high PPL realization rate provides advantage in competition. The PPL realization rate is coupled with the rate of leaf senescence.
[Mh] Termos MeSH primário: Lauraceae/fisiologia
Modelos Estatísticos
Fotossíntese/fisiologia
Folhas de Planta/fisiologia
Rosales/fisiologia
Theaceae/fisiologia
[Mh] Termos MeSH secundário: Ecossistema
Luz
Estações do Ano
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150723
[Lr] Data última revisão:
150723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150724
[St] Status:MEDLINE


  10 / 1333 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26068425
[Au] Autor:Joseph N; Tom Esther NL; Télesphore Benoît N; Paul Désiré DD; Oumarou Bibi-Farouck A; Théophile D; Pierre K
[Ad] Endereço:Laboratory of Animal Physiology, Department of Animal Biology, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon.
[Ti] Título:Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum.
[So] Source:J Ethnopharmacol;172:1-9, 2015 Aug 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Pittosporum mannii Hook. f. (Pittosporaceae) is a plant widely used in traditional medicine in Cameroon for the treatment of many gastrointestinal disorders including diarrhea. To date, no pharmacological study on the antidiarrheal and the antispasmodic properties of this plant has been reported. The aim of the present study was to evaluate in vitro the relaxant activity of the aqueous extract of stem barks of P. mannii (PMAE) on rat duodenum. MATERIALS AND METHODS: Different concentrations of PMAE were tested separately (10-80 µg/mL) or cumulatively (5-80 µg/mL) on spontaneous and spasmogen (carbachol, histamine and KCl)-induced contractions of isolated rat duodenum strips. RESULTS: At concentrations ranging from 10 to 80 µg/mL, PMAE significantly decreased the tonus and the amplitude of spontaneous contractions. However, at high concentration (80 µg/mL), the extract elicited a transient relaxation was followed by a slight increase of tonus, while the amplitude remained lower compared to the normal spontaneous activity. The relaxant effect of the extract was not significantly affected in the presence of atropine (0.713 µg/mL) and promethazine (0.5 µg/mL). In addition, PMAE (20, 40, and 80 µg/mL) partially but significantly inhibited in a concentration related manner the contractions induced by carbachol (10(-9)-10(-4)M) and histamine (10(-9)-10(-4)M) on rat duodenum. PMAE (10-80 µg/mL) also significantly induced a concentration-dependent relaxation on KCl (20mM, 50mM, 10(-3)-6.10(-3)M)-induced contraction of rat duodenum. CONCLUSIONS: These results show that the aqueous extract of P. mannii stem barks possesses antispasmodic and spasmolytic effects at lower concentrations; therefore, supporting the use of the stem barks of this plant in the folk medicine for the treatment of diarrhea. However, caution should be paid while using higher concentrations that instead might produce spasmogenic effect and might worsen the diarrheal condition. The relaxant effect of PMAE appears to be non-specific of muscarinic or histaminic receptors, but may involve at least in part a mechanism of inhibition of the Ca(2+) influx into the smooth muscle cells through voltage-operated Ca(2+) channels.
[Mh] Termos MeSH primário: Duodeno/efeitos dos fármacos
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Casca de Planta/química
Extratos Vegetais/farmacologia
Caules de Planta/química
Rosales/química
[Mh] Termos MeSH secundário: Animais
Atropina/farmacologia
Carbacol/antagonistas & inibidores
Carbacol/farmacologia
Relação Dose-Resposta a Droga
Duodeno/fisiologia
Histamina/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Técnicas In Vitro
Masculino
Medicina Tradicional
Contração Muscular/fisiologia
Músculo Liso/fisiologia
Parassimpatolíticos/farmacologia
Extratos Vegetais/química
Cloreto de Potássio/antagonistas & inibidores
Cloreto de Potássio/farmacologia
Prometazina/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine Antagonists); 0 (Parasympatholytics); 0 (Plant Extracts); 660YQ98I10 (Potassium Chloride); 7C0697DR9I (Atropine); 820484N8I3 (Histamine); 8Y164V895Y (Carbachol); FF28EJQ494 (Promethazine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150803
[Lr] Data última revisão:
150803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150613
[St] Status:MEDLINE



página 1 de 134 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde