Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.055.750 [Categoria DeCS]
Referências encontradas : 560 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 56 ir para página                         

  1 / 560 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29254897
[Au] Autor:Yang HH; Oh KE; Jo YH; Ahn JH; Liu Q; Turk A; Jang JY; Hwang BY; Lee KY; Lee MK
[Ad] Endereço:College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
[Ti] Título:Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay.
[So] Source:Bioorg Med Chem;26(2):509-515, 2018 01 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the screening of natural products for the development as cosmetic ingredients, the EtOAc-soluble fraction of Humulus japonicus showed tyrosinase inhibitory activity. HPLC-MS/MS coupled online tyrosinase assay of EtOAc-soluble fraction of H. japonicus characterized the twenty-eight constituents including two unknown ones and their tyrosinase inhibitory activity. Fractionation of H. japonicus using various chromatographic techniques yielded thirty-eight compounds. The chemical structures of isolated compounds were identified by spectroscopic analysis. As characterized by HPLC-MS/MS analysis, we isolated twenty-four predicted compounds and further identified two unknown ones, named humulusides A (1) and B (2). Additional ten compounds were also identified by purification. Tyrosinase inhibitory activity of isolated compounds were evaluated, which was closely correlated with the results from HPLC-MS/MS coupled online tyrosinase assay. Consistent with predicted data, two major compounds, trans-N-coumaroyltyramine (14) and cis-N-coumaroyltyramine (15) showed tyrosinase inhibition with IC values of 40.6 and 36.4 µM. Taken together, H. japonicus is suggested as whitening ingredient in cosmetic products. In addition, HPLC-MS/MS coupled tyrosinase assay is powerful tool for predicting active compounds with short time and limited amounts, although identification of new compounds and verification of predicted data are also needs to be demonstrated by further experiment.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Humulus/química
Monofenol Mono-Oxigenase/antagonistas & inibidores
Componentes Aéreos da Planta/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Seres Humanos
Estrutura Molecular
Monofenol Mono-Oxigenase/metabolismo
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Relação Estrutura-Atividade
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28964928
[Au] Autor:Keiler AM; Macejova D; Dietz BM; Bolton JL; Pauli GF; Chen SN; van Breemen RB; Nikolic D; Goerl F; Muders MH; Zierau O; Vollmer G
[Ad] Endereço:Chair for Molecular Cell Physiology & Endocrinology, Department of Biology, Technische Universität Dresden, 01062 Dresden, Germany; Institute for Doping Analytics and Sports Biochemistry Dresden (IDAS), Dresdner Str. 12, 01731 Kreischa, Germany.
[Ti] Título:Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.
[So] Source:J Steroid Biochem Mol Biol;174:234-241, 2017 Nov.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Supplements with estrogenic activities are intensively investigated as potential alternatives for the treatment of menopausal symptoms. These investigations include studies on their safety regarding potential breast cancer risks. Therefore, the aim of this study was to assess whether or not a standardized hops (Humulus lupulus) extract, containing 0.42% of the estrogenic flavanone, 8-prenylnaringenin, would stimulate growth of methyl-nitrosourea (MNU) induced mammary cancer in ovariectomized (OVX) Sprague-Dawley (SD) rats or would impact on the proliferative activity within the normal mammary gland of Wistar rats. To induce tumorigenesis SD-rats received an intraperitoneal injection of 50mg/kg body weight of MNU on postnatal days PND 50 and 52. 28days later animals were OVX or were SHAM operated (positive control) and randomly allocated and maintained for 140days on either a phytoestrogen-free placebo diet (SHAM and negative control) or on the hops fortified diet. For the investigations in the normal mammary gland young adult Wistar rats were bilaterally OVX and randomly allocated to a control group fed to a phytoestrogen-free diet, or to a diet supplemented either with E -benzoate or the hops extract. As a major result, the tumor incidence was 15% (3 tumors totally) in OVX controls, whereas it was 85% (39 tumors totally) in SHAM operated positive controls. No tumors were detectable in the hops group. In addition, no estrogenic activity of the hops extract was detectable in uterus and liver of these animals. In investigations on the normal mammary gland, no impact of hops extract on the expression of estrogen dependent proliferation markers or of progesterone receptor became apparent. In conclusion, the lack of growth stimulation of MNU-induced breast cancer in OVX SD-rats and the lack of stimulation proliferative events in the normal mammary gland of OVX Wistar rats by standardized hops extracts provides an important piece of evidence regarding the safety of these extracts in the management of menopausal symptoms.
[Mh] Termos MeSH primário: Humulus
Glândulas Mamárias Animais/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alquilantes
Animais
Proliferação Celular/efeitos dos fármacos
Chalconas/sangue
Chalconas/metabolismo
Feminino
Flavanonas/sangue
Flavanonas/metabolismo
Fígado/efeitos dos fármacos
Fígado/crescimento & desenvolvimento
Fígado/metabolismo
Neoplasias Mamárias Experimentais/induzido quimicamente
Metilnitrosoureia
Tamanho do Órgão/efeitos dos fármacos
Ovariectomia
Ratos Sprague-Dawley
Ratos Wistar
Útero/efeitos dos fármacos
Útero/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkylating Agents); 0 (Chalcones); 0 (Flavanones); 0 (Plant Extracts); 684-93-5 (Methylnitrosourea)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


  3 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28960474
[Au] Autor:Cermak P; Olsovska J; Mikyska A; Dusek M; Kadleckova Z; Vanicek J; Nyc O; Sigler K; Bostikova V; Bostik P
[Ad] Endereço:Thomayer Hospital, Videnska 800, Prague, Czech Republic.
[Ti] Título:Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria.
[So] Source:APMIS;125(11):1033-1038, 2017 Nov.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B. fragilis, C. perfringens and C. difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C. difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107 µg/mL, which are close to those of conventional antibiotics in the strains of bacteria with increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clostridium difficile/efeitos dos fármacos
Cicloexenos/farmacologia
Flavonoides/farmacologia
Humulus/química
Propiofenonas/farmacologia
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Anaerobiose/fisiologia
Antibacterianos/isolamento & purificação
Bacteroides fragilis/efeitos dos fármacos
Bacteroides fragilis/crescimento & desenvolvimento
Clostridium difficile/crescimento & desenvolvimento
Clostridium difficile/patogenicidade
Clostridium perfringens/efeitos dos fármacos
Clostridium perfringens/crescimento & desenvolvimento
Infecção Hospitalar/microbiologia
Cicloexenos/isolamento & purificação
Diarreia/microbiologia
Enterocolite Pseudomembranosa/microbiologia
Flavonoides/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
Propiofenonas/isolamento & purificação
Simbiose/fisiologia
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cyclohexenes); 0 (Flavonoids); 0 (Plant Extracts); 0 (Propiophenones); 0 (Terpenes); B7425USG94 (lupulon); KHB4767H3K (humulon); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12747


  4 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28886174
[Au] Autor:Pokorn T; Radisek S; Javornik B; Stajner N; Jakse J
[Ad] Endereço:Agronomy Department, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
[Ti] Título:Development of hop transcriptome to support research into host-viroid interactions.
[So] Source:PLoS One;12(9):e0184528, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viroids, the smallest known pathogens, unable to encode any proteins, can cause severe diseases in their host plants. One of the proposed mechanisms of their pathogenicity includes silencing the host's genes via viroid-derived small RNAs, which are products of the host's immune response to the viroid's double stranded RNA. Humulus lupulus (hop) plants are hosts to several viroids; two of them, HLVd and CBCVd, are interesting models for studying host-viroid interactions, due to the symptomless infection of the former and severe stunting disease caused by the latter. To study these interactions, we constructed a deep hop NGS transcriptome based on 35 Gb paired-end sequencing data assembled into over 74 Mb of contigs. These transcripts were used for in-silico prediction of target transcripts of vd-sRNA of the two aforementioned viroids, using two different software tools. Prediction models revealed that 1062 and 1387 hop transcripts share nucleotide similarities with HLVd- and CBCVd-derived small RNAs, respectively, so they could be silenced in an RNA interference process. Furthermore, we selected 17 transcripts from 4 groups of targets involved in the metabolism of plant hormones, small RNA biogenesis, transcripts with high complementarity with viroid-derived small RNAs and transcripts targeted by CBCVd-derived small RNAs with high cellular concentrations. Their expression was monitored by reverse transcription quantitative PCR performed using leaf, flower and cone samples. Additionally, the expression of 5 pathogenesis related genes was monitored. Expression analysis confirmed high expression levels of four pathogenesis related genes in leaves of HLVd and CBCVd infected hop plants. Expression fluctuations were observed for the majority of targets, with possible evidence of downregulation of GATA transcription factor by CBCVd- and of linoleate 13S-lipoxygenase by HLVd-derived small RNAs. These results provide a deep transcriptome of hop and the first insights into complex viroid-hop plant interactions.
[Mh] Termos MeSH primário: Interações Hospedeiro-Patógeno/genética
Humulus/genética
Doenças das Plantas/genética
Doenças das Plantas/virologia
Transcriptoma
Viroides/genética
[Mh] Termos MeSH secundário: Biologia Computacional/métodos
Perfilação da Expressão Gênica
Ontologia Genética
Sequenciamento de Nucleotídeos em Larga Escala
Anotação de Sequência Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184528


  5 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28812892
[Au] Autor:Dietz BM; Chen SN; Alvarenga RFR; Dong H; Nikolic D; Biendl M; van Breemen RB; Bolton JL; Pauli GF
[Ti] Título:DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.
[So] Source:J Nat Prod;80(8):2284-2294, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Botanical dietary supplements contain multiple bioactive compounds that target numerous biological pathways. The lack of uniform standardization requirements is one reason that inconsistent clinical effects are reported frequently. The multifaceted biological interactions of active principles can be disentangled by a coupled pharmacological/phytochemical approach using specialized ("knock-out") extracts. This is demonstrated for hops, a botanical for menopausal symptom management. Employing targeted, adsorbent-free countercurrent separation, Humulus lupulus extracts were designed for pre- and postmenopausal women by containing various amounts of the phytoestrogen 8-prenylnaringenin (8-PN) and the chemopreventive constituent xanthohumol (XH). Analysis of their estrogenic (alkaline phosphatase), chemopreventive (NAD(P)H-quinone oxidoreductase 1 [NQO1]), and cytotoxic bioactivities revealed that the estrogenicity of hops is a function of 8-PN, whereas their NQO1 induction and cytotoxic properties depend on XH levels. Antagonization of the estrogenicity of 8-PN by elevated XH concentrations provided evidence for the interdependence of the biological effects. A designed postmenopausal hop extract was prepared to balance 8-PN and XH levels for both estrogenic and chemopreventive properties. An extract designed for premenopausal women contains reduced 8-PN levels and high XH concentrations to minimize estrogenic while retaining chemopreventive properties. This study demonstrates the feasibility of modulating the concentrations of bioactive compounds in botanical extracts for potentially improved efficacy and safety.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Flavanonas/isolamento & purificação
Flavanonas/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacocinética
Humulus/química
Fitoestrógenos/isolamento & purificação
Fitoestrógenos/farmacologia
Propiofenonas/isolamento & purificação
Propiofenonas/farmacocinética
[Mh] Termos MeSH secundário: Suplementos Nutricionais
Estrogênios/química
Feminino
Flavanonas/química
Flavonoides/química
Seres Humanos
Estrutura Molecular
Fitoestrógenos/química
Propiofenonas/química
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-prenylnaringenin); 0 (Estrogens); 0 (Flavanones); 0 (Flavonoids); 0 (Phytoestrogens); 0 (Propiophenones); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00284


  6 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28812343
[Au] Autor:Chen SF; Chen PY; Hsu HJ; Wu MJ; Yen JH
[Ad] Endereço:Department of Molecular Biology and Human Genetics, Tzu Chi University , Hualien 970, Taiwan.
[Ti] Título:Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells.
[So] Source:J Agric Food Chem;65(36):7908-7918, 2017 Sep 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Xanthohumol, a prenylated flavonoid found in hops (Humulus lupulus L.), exhibits multiple biological activities such as antiatherosclerosis and hypolipidemic activities. In this study, we aim to investigate the hypocholesterolemic effects and molecular mechanisms of xanthohumol in hepatic cells. We found that xanthohumol (10 and 20 µM) increased the amount of cell-surface low-density lipoprotein receptor (LDLR) from 100.0 ± 2.1% to 115.0 ± 1.3% and 135.2 ± 2.7%, and enhanced the LDL uptake activity from 100.0 ± 0.9% to 139.1 ± 13.2% in HepG2 cells (p < 0.01). The mRNA levels of LDLR, HMGCR, and PCSK9 were not altered. Xanthohumol (20 µM) reduced the expression of inducible degrader of the LDL receptor (Mylip/Idol) mRNA and protein by approximately 45% (p < 0.01), which was reported to be associated with increases of LDLR level. We demonstrated that xanthohumol suppressed hepatic Mylip/Idol expression via counteracting liver X receptor (LXR) activation. The molecular docking results predicted that xanthohumol has a high binding affinity to interact with the LXRα ligand-binding domain, which may result in attenuation of LXRα-induced Mylip/Idol expression. Finally, we demonstrated that the Mylip/Idol expression and LDLR activity were synergistically changed by a combination of xanthohumol and simvastatin treatment. Our findings indicated that xanthohumol may regulate the LXR-Mylip/Idol axis to modulate hepatic LDLR abundance and activity.
[Mh] Termos MeSH primário: Flavonoides/farmacologia
Humulus/química
Extratos Vegetais/farmacologia
Propiofenonas/farmacologia
Receptores de LDL/metabolismo
Ubiquitina-Proteína Ligases/genética
[Mh] Termos MeSH secundário: Regulação para Baixo/efeitos dos fármacos
Células Hep G2
Seres Humanos
Receptores de LDL/genética
Ubiquitina-Proteína Ligases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Propiophenones); 0 (Receptors, LDL); EC 2.3.2.27 (MYLIP protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02282


  7 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28627872
[Au] Autor:Liu R; Heiss EH; Schachner D; Jiang B; Liu W; Breuss JM; Dirsch VM; Atanasov AG
[Ad] Endereço:School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai, 264005, People's Republic of China.
[Ti] Título:Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.
[So] Source:J Nat Prod;80(7):2146-2150, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was to examine its influence on platelet-derived growth factor (PDGF)-BB-triggered vascular smooth muscle cell (VSMC) proliferation and migration in vitro and on experimentally induced neointima formation in vivo. Quantification of resazurin conversion indicated that 1 can inhibit PDGF-BB-induced VSMC proliferation concentration-dependently (IC = 3.49 µM). Furthermore, in a wound-healing assay 1 potently suppresses PDGF-BB-induced VSMC migration at 15 µM. Tested in a mouse femoral artery cuff model, 1 significantly reduces neointima formation. Taken together, we show that 1 represses PDGF-BB-induced VSMC proliferation and migration in vitro as well as neointima formation in vivo. This novel activity suggests 1 as an interesting candidate for further studies addressing a possible therapeutic application to counteract vascular proliferative disease.
[Mh] Termos MeSH primário: Flavonoides/farmacologia
Humulus/química
Neointima/metabolismo
Propiofenonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Proliferação Celular
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Flavonoides/química
Flavonoides/isolamento & purificação
Sistema de Sinalização das MAP Quinases
Camundongos
Estrutura Molecular
Músculo Liso Vascular/metabolismo
Miócitos de Músculo Liso/metabolismo
Neointima/induzido quimicamente
Oxazinas/metabolismo
Fosforilação
Fator de Crescimento Derivado de Plaquetas/efeitos dos fármacos
Propiofenonas/química
Propiofenonas/isolamento & purificação
Proteínas Proto-Oncogênicas c-sis
Ratos
Ratos Sprague-Dawley
Transdução de Sinais
Cicatrização/efeitos dos fármacos
Xantenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Oxazines); 0 (Platelet-Derived Growth Factor); 0 (Propiophenones); 0 (Proto-Oncogene Proteins c-sis); 0 (Xanthenes); 1B56C968OA (becaplermin); 1FN9YD6968 (resazurin); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00268


  8 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28415075
[Au] Autor:Hill ST; Sudarsanam R; Henning J; Hendrix D
[Ad] Endereço:Electrical Engineering and Computer Science, Oregon State University.
[Ti] Título:HopBase: a unified resource for Humulus genomics.
[So] Source:Database (Oxford);2017(1), 2017 Jan 01.
[Is] ISSN:1758-0463
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hop (Humulus lupulus L. var lupulus) is a dioecious plant of worldwide significance, used primarily for bittering and flavoring in brewing beer. Studies on the medicinal properties of several unique compounds produced by hop have led to additional interest from pharmacy and healthcare industries as well as livestock production as a natural antibiotic. Genomic research in hop has resulted a published draft genome and transcriptome assemblies. As research into the genomics of hop has gained interest, there is a critical need for centralized online genomic resources. To support the growing research community, we report the development of an online resource "HopBase.org." In addition to providing a gene annotation to the existing Shinsuwase draft genome, HopBase makes available genome assemblies and annotations for both the cultivar "Teamaker" and male hop accession number USDA 21422M. These genome assemblies, gene annotations, along with other common data, coupled with a genome browser and BLAST database enable the hop community to enter the genomic age. The HopBase genomic resource is accessible at http://hopbase.org and http://hopbase.cgrb.oregonstate.edu.
[Mh] Termos MeSH primário: Genoma de Planta
Humulus/genética
[Mh] Termos MeSH secundário: RNA Mensageiro/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1093/database/bax009


  9 / 560 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28413193
[Au] Autor:Takahashi K; Osada K
[Ad] Endereço:Department of Agricultural Chemistry, School of Agriculture, Meiji University.
[Ti] Título:Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice.
[So] Source:J Oleo Sci;66(5):531-541, 2017 May 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high-fat diet through regulation of fatty acid metabolism. In this study, we examined the effects of dietary purified xanthohumol from XRHE (PX, ~91.9% xanthohumol) in KK-Ay mice in order to understand the anti-obesity effects of xanthohumol alone because XRHE contains 82% unknown compounds. Dietary consumption of PX significantly inhibited an increase in the visceral fat weight of mice compared to those fed control diet without PX. Plasma leptin level was significantly lower in the PX-fed group than in the control group. Dietary PX lowered hepatic fatty acid synthesis by down-regulation of SREBP1c mRNA expression in the liver. On the other hand, fatty acid ß-oxidation in the liver was promoted by dietary PX through the up-regulation of PPARα mRNA expression. Moreover, the fecal levels of fatty acids and carbohydrates increased by dietary PX. PX inhibited lipase or α-amylase activity in vitro. Thus, we found that PX may exert anti-obesity effects through the regulation of lipid metabolism and inhibition of intestinal fat and carbohydrate absorption, and that xanthohumol alone may exert anti-obesity effects.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Fármacos Antiobesidade
Glicemia/metabolismo
Diabetes Mellitus/metabolismo
Jejum/sangue
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Humulus/química
Metabolismo dos Lipídeos
Obesidade/metabolismo
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Propiofenonas/isolamento & purificação
Propiofenonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Metabolismo dos Carboidratos/efeitos dos fármacos
Modelos Animais de Doenças
Ácidos Graxos/metabolismo
Intestinos/metabolismo
Leptina/sangue
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos
Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Blood Glucose); 0 (Fatty Acids); 0 (Flavonoids); 0 (Leptin); 0 (Plant Extracts); 0 (Propiophenones); 0 (Srebf1 protein, rat); 0 (Sterol Regulatory Element Binding Protein 1); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16234


  10 / 560 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28334066
[Au] Autor:Calderwood L; Cubins J; Vesty D; Darby H
[Ad] Endereço:Department of Plant and Soil Science, University of Vermont, 63 Carrigan Dr., Burlington, VT 05405 (lbc75@cornell.edu; julija.cubins@uvm.edu; dbvesty@uvm.edu).
[Ti] Título:Effect of Drive Row Ground Covers on Hop (Rosales: Cannabaceae) Yard Arthropod Pests in Vermont, USA.
[So] Source:Environ Entomol;46(2):183-190, 2017 04 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alternatives to pesticides are necessary for the management of hop (Humulus lupulus L.) arthropod pests. The three major arthropod pests in northeastern US hop production include two-spotted spider mite, Tetranychus urticae Koch, hop aphid Phorodon humuli (Schrank), and potato leafhopper, Empoasca fabae Harris. This 3-yr study (2012-2014) in Vermont investigated the effect of flowering ground covers on arthropod pest abundance. Hop cultivars 'Nugget' and 'Cascade' were evaluated under a strip-split plot experimental design. Ground cover treatments included 1) Control: mowed red clover (Trifolium pratense) and resident weeds, 2) Clover: red clover, and 3) Diverse: common yarrow (Achillea millefolium), beebalm (Monarda fistulosa), red clover, and annual sunflower (Helianthus annuus). Natural enemies were grouped by associated pest and indicated by our mixed model to be strong predictors of the number of hop aphid and potato leafhopper on hop plants. In year two, ground cover treatment had a significant effect on two-spotted spider mite abundance where fewer two-spotted spider mite were observed on hop plants in Diverse plots. The established, un-mowed Clover treatment was preferred by potato leafhopper over Diverse ground cover and hop plants. This revealed the potential for clover ground cover to serve as a trap crop for potato leafhopper management in northeastern hop yards. Our findings are evidence that ground covers implemented for conservation biological control may serve more specific pest management functions instead of or in addition to boosting top-down pest pressure.
[Mh] Termos MeSH primário: Agricultura/métodos
Humulus/crescimento & desenvolvimento
Magnoliopsida/crescimento & desenvolvimento
Controle Biológico de Vetores
Tetranychidae/fisiologia
[Mh] Termos MeSH secundário: Animais
Afídeos/fisiologia
Hemípteros/fisiologia
Dinâmica Populacional
Estações do Ano
Vermont
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvw069



página 1 de 56 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde