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Pesquisa : B01.650.940.800.575.912.250.859.937.055.875 [Categoria DeCS]
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  1 / 20 MEDLINE  
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[PMID]:28810849
[Au] Autor:Olanlokun JO; David OM; Afolayan AJ
[Ad] Endereço:Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. jodel72000@yahoo.com.
[Ti] Título:In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark.
[So] Source:BMC Complement Altern Med;17(1):407, 2017 Aug 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Trema orientalis (T. orientalis Linn) has been used in the management of malaria in the western part of Nigeria and despite its application in ethnomedicine, there is dearth of scientific evidence to justify the acclaimed prophylactic antimalarial usage of the plant. The aim of this study is to assess the in vitro antiplasmodial cell-free assay and chemopreventive efficacy of the methanol extract of the stem bark of T. orientalis and its fractions as a prophylactic regimen for malaria prevention. Also, the antimicrobial activities of the extract and the fractions were investigated. METHOD: Vacuum liquid chromatography was used to obtain dichloromethane, ethylacetate and methanol fractions from the methanol extract of T. orientalis. The fractions were tested for their prophylactic and cell-free antimalarial activity using murine models and ß-hematin formation assay respectively. Disc diffusion method was used to determine the antibacterial activity of the extract and its fractions against both Gram-positive and Gram-negative bacteria. RESULTS: In the prophylactic experiment, dichloromethane (DCMF), methanol fraction (MF) and extract (ME) (in this order) showed significant chemopreventive effects against P. berghei invasion of the red blood cells when compared with both Sulfadoxine-Pyrimethamine (SP) and untreated controls. Results of the in vitro study showed that the DCMF had the highest effect in preventing the formation of ß-hematin when compared with other fractions. The DCMF also had the highest percentage inhibition of ß-hematin formation when compared with chloroquine. The extract and fractions showed a concentration dependent antibacterial activity. Methanol extract had a pronounced inhibitory effect on Enterobacter cloaca ATCC 13047 and Enterococcus faecalis ATCC 29212. Serratia mercescens ATCC 9986 and Pseudomonas aeruginosa ATCC 19582 were the most susceptible bacteria. CONCLUSION: The results obtained showed that both extract and fractions of T. orientalis possessed antiplasmodial and antimicrobial activity.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Malária/prevenção & controle
Fitoterapia
Extratos Vegetais/uso terapêutico
Plasmodium berghei/efeitos dos fármacos
Trema
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Antimaláricos/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Hemeproteínas/metabolismo
Malária/sangue
Malária/parasitologia
Masculino
Camundongos
Casca de Planta
Extratos Vegetais/farmacologia
Caules de Planta
Plasmodium berghei/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antimalarials); 0 (Hemeproteins); 0 (Plant Extracts); 39404-00-7 (hemozoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1914-x


  2 / 20 MEDLINE  
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[PMID]:25902818
[Au] Autor:Emran TB; Rahman MA; Uddin MM; Rahman MM; Uddin MZ; Dash R; Layzu C
[Ad] Endereço:Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4000, Bangladesh. talhabmb@gmail.com.
[Ti] Título:Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis.
[So] Source:BMC Complement Altern Med;15:128, 2015 Apr 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The increasingly high incidence of ischemic stroke caused by thrombosis of the arterial vessels is one of the major factors that threaten people's health and lives in the world. The present treatments for thrombosis are still unsatisfactory. Herbal preparations have been used since ancient times for the treatment of several diseases. The aim of this study was to investigate whether herbal preparations possess thrombolytic activity or not. METHODS: An in vitro thrombolytic model was used to check the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata L. using streptokinase as a positive control and water as a negative control. Briefly, venous blood drawn from twenty healthy volunteers was allowed to form clots which were weighed and treated with the test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis. RESULTS: Using an in vitro thrombolytic model, different fractions of five Bangladeshi medicinal plants namely T. orientalis, B. monnieri, C. frutescens, B. oleracea and U. sinuata showed various range of clot lysis activity. Chloroform fractions of T. orientalis, B. monnieri, C. frutescens, B. oleracea and U. sinuata showed highest significant (P < 0.05 and P < 0.001) clot lysis activity viz., 46.44 ± 2.44%, 48.39 ± 10.12%, 36.87 ± .27%, 30.24 ± 0.95% and 47.89 ± 6.83% respectively compared with positive control standard streptokinase (80.77 ± 1.12%) and negative control sterile distilled water (5.69 ± 3.09%). Other fractions showed moderate to low clot lysis activity. Order of clot lysis activity was found to be: Streptokinase > Chloroform fractions > Methanol (crude) extract > Hydro-methanol fractions > Ethyl acetate fractions > n-hexane fractions > Water. CONCLUSIONS: Our study suggests that thrombolytic activity of T. orientalis, B. monnieri and U. sinuata could be considered as very promising and beneficial for the Bangladeshi traditional medicine. Lower effects of other extracts might suggest the lack of bio-active components and/or insufficient quantities in the extract. In vivo clot dissolving property and active component(s) of T. orientalis and B. monnieri for clot lysis could lead the plants for their therapeutic uses. However, further work will establish whether or not, chloroform soluble phytochemicals from these plants could be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases.
[Mh] Termos MeSH primário: Fibrinólise/efeitos dos fármacos
Fibrinolíticos/uso terapêutico
Magnoliopsida
Fitoterapia
Extratos Vegetais/uso terapêutico
Trombose/tratamento farmacológico
[Mh] Termos MeSH secundário: Bacopa
Bangladesh
Brassica
Capsicum
Fibrinolíticos/farmacologia
Seres Humanos
Malvaceae
Extratos Vegetais/farmacologia
Plantas Medicinais
Estreptoquinase/farmacologia
Acidente Vascular Cerebral/prevenção & controle
Trema
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrinolytic Agents); 0 (Plant Extracts); EC 3.4.- (Streptokinase)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150424
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0643-2


  3 / 20 MEDLINE  
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[PMID]:25222784
[Au] Autor:Rawani A; Ghosh A; Chandra G
[Ti] Título:Mosquito larvicidal potential of four common medicinal plants of India.
[So] Source:Indian J Med Res;140(1):102-8, 2014 Jul.
[Is] ISSN:0971-5916
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & OBJECTIVES: Mosquitoes transmit serious human health diseases, causing millions of deaths every year. Plants may be sources of alternative mosquito control agents. The present study was carried out to assess the role of larvicidal activities of the crude extracts of four plants viz. Alternanthera sessilis L. (Amaranthaceae), Trema orientalis L. (Cannabaceae), Gardenia carinata Smith. (Rubiaceae) and Ruellia tuberosa L. (Acanthaceae) against Culex quinquefasciatus Say in laboratory bioassay. METHODS: Selective concentrations (0.5, 1 and 1.5%) of crude extract of all four plant leaves were tested against I st to IV th instar larvae of Cx. quinquefasciatus. Log probit analysis (at 95% confidence level) revealed the LC50 values. Preliminary qualitative phytochemical analyses of crude extracts were also done. The lethal concentrations (%) of crude extracts at 24 h against III rd instar larvae were also studied on non-target organisms. RESULT: In a 72 h bioassay experiment with crude extract, the highest mortality was recorded in 1.5 per cent extract. A. sessilis showed the highest mortality (76.7%) at 1.5 per cent crude extract against II nd instar larvae having LC50 value of 0.35 per cent, followed by R. tuberosa (LC50 = 1.84%), G. carinata (LC50 = 2.11) and T. orientalis (LC50 = 2.95%). The regression equation showed a dose-dependent mortality, as the rate of mortality (Y) was positively correlated with the concentration (X). Phytochemical analysis of the crude extract showed the presence of many bioactive phytochemicals such as steroids, alkaloids, terpenes, saponins, etc. No changes in the swimming behaviour and survivality of non-target organism were noticed at the studied concentrations. INTERPRETATION & CONCLUSIONS: Crude extract of the four selected plants showed larvicidal activity against Cx. quinquefasciatus. The extracts at the studied concentrations did not produce any harmful effect on non-target organisms.
[Mh] Termos MeSH primário: Acanthaceae/química
Amaranthaceae/química
Culicidae/efeitos dos fármacos
Gardenia/química
Inseticidas/farmacologia
Controle de Mosquitos/métodos
Extratos Vegetais/farmacologia
Trema/química
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Índia
Larva/efeitos dos fármacos
Dose Letal Mediana
Extratos Vegetais/análise
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Plant Extracts)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150804
[Lr] Data última revisão:
150804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140916
[St] Status:MEDLINE


  4 / 20 MEDLINE  
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[PMID]:24292716
[Au] Autor:Osone Y; Yazaki K; Masaki T; Ishida A
[Ad] Endereço:Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji, Tokyo, 192-0397, Japan, ik2s-kkc@asahi-net.or.jp.
[Ti] Título:Responses to nitrogen pulses and growth under low nitrogen availability in invasive and native tree species with differing successional status.
[So] Source:J Plant Res;127(2):315-28, 2014 Mar.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Invasive species are frequently found in recently disturbed sites. To examine how these disturbance-dependent invasive species exploit resource pulses resulting from disturbance, twelve physiological and morphological traits, including age-dependent responsiveness in leaf traits to nitrogen pulse, were compared between Bischofia javanica, an invasive tree species in Ogasawara islands, and three native Ogasawara species, each having a different successional status. When exposed to a nitrogen pulse, invasive B. javanica showed higher increases in photosynthetic capacity, leaf area, epidermal cell number and cell size in leaves of broad age classes, and root nitrogen absorption ability than two native mid-/late or late-successional species, but showed no particular superiority to a native pioneer species in these responses. Under low nitrogen, however, it showed the largest relative growth rate among the four species, while the native pioneer showed the lowest growth. From these results, we concluded that the combination of moderately high responsiveness to resource pulses and the ability to maintain steady growth under resource limitations may give B. javanica a competitive advantage over a series of native species with different successional status from early to late-successional stages.
[Mh] Termos MeSH primário: Magnoliopsida/fisiologia
Nitrogênio/metabolismo
Fotossíntese
[Mh] Termos MeSH secundário: Elaeocarpaceae/anatomia & histologia
Elaeocarpaceae/crescimento & desenvolvimento
Elaeocarpaceae/fisiologia
Elaeocarpaceae/efeitos da radiação
Espécies Introduzidas
Ilhas
Japão
Luz
Magnoliopsida/anatomia & histologia
Magnoliopsida/crescimento & desenvolvimento
Magnoliopsida/efeitos da radiação
Oceano Pacífico
Fenótipo
Folhas de Planta/anatomia & histologia
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/fisiologia
Folhas de Planta/efeitos da radiação
Raízes de Plantas/anatomia & histologia
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/fisiologia
Raízes de Plantas/efeitos da radiação
Transpiração Vegetal
Plântulas/anatomia & histologia
Plântulas/crescimento & desenvolvimento
Plântulas/fisiologia
Plântulas/efeitos da radiação
Especificidade da Espécie
Fatores de Tempo
Árvores
Trema/anatomia & histologia
Trema/crescimento & desenvolvimento
Trema/fisiologia
Trema/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
N762921K75 (Nitrogen)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131203
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-013-0609-8


  5 / 20 MEDLINE  
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[PMID]:23609305
[Au] Autor:Wang F; Li J; Zou B; Xu X; Li Z
[Ad] Endereço:Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510160, People's Republic of China.
[Ti] Título:Effect of prescribed fire on soil properties and N transformation in two vegetation types in South China.
[So] Source:Environ Manage;51(6):1164-73, 2013 Jun.
[Is] ISSN:1432-1009
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prescribed fire is a common site preparation practice in forest management in southern China. However, the effect of fire on soil properties and N transformations is still poorly understood in this region. In this study, soil properties and N transformations in burned and unburned site of two vegetation types (Eucalyptus plantation and shrubland) were compared in rainy and dry seasons after 2 years' prescribed fire. Soil pH and soil NH4-N were all higher in the burned site compared to the unburned control. Furthermore, burned sites had 30-40 % lower of soil total phosphorus than conspecific unburned sites. There was no difference in soil organic matter, total N, soil exchangeable cations, available P or NO3-N. Nitrogen mineralization rate of 0-5 cm soil in the unburned site ranged from 8.24 to 11.6 mg N kg(-1) soil month(-1) in the rainy season, compared to a lower level of 4.82-5.25 mg N kg(-1) soil month(-1) in the burned sites. In contrast, 0-5 cm layer nitrification rate was overall 2.47 mg N kg(-1) soil month(-1) in the rainy season, and was not significantly affected by burning. The reduced understory vegetation coverage after burning may be responsible for the higher soil NH4-N in the burned site. This study highlights that a better understanding the effect of prescribed burning on soil nutrients cycling would provide a critical foundation for management decision and be beneficial to afforestation in southern China.
[Mh] Termos MeSH primário: Fogo
Agricultura Florestal/métodos
Nitrogênio/análise
Solo/química
[Mh] Termos MeSH secundário: Compostos de Amônio/análise
China
Eucalyptus
Myrtaceae
Traqueófitas
Trema
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Soil); N762921K75 (Nitrogen)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130424
[St] Status:MEDLINE
[do] DOI:10.1007/s00267-013-0044-6


  6 / 20 MEDLINE  
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[PMID]:23417165
[Au] Autor:Wouters F; Wouters AT; Watanabe TT; Soares MP; Cruz CE; Driemeier D
[Ad] Endereço:Departamento de Patologia Clínica, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9090, Agronomia, Porto Alegre-RS, Brazil.
[Ti] Título:Pneumotoxicosis in sheep caused by ingestion of trema micrantha.
[So] Source:Vet Pathol;50(5):775-8, 2013 Sep.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trema micrantha, a fast-growing tree distributed throughout the Americas, produces palatable leaves that have been associated with hepatic necrosis and acute death when consumed by livestock. This report describes fatal pulmonary disease of sheep triggered by consumption of Trema micrantha. Affected sheep had severe progressive dyspnea for a few days before death. Subcutaneous and mediastinal emphysema, reddened lungs, interalveolar septal thickening, and diffuse type II pneumocyte proliferation were the main pathological findings. After ingesting 77.5 and 102.5 g/kg (divided in 3 doses, at 30-day intervals) of T. micrantha leaves, 2 additional sheep developed the same condition. These findings indicate that T. micrantha toxicosis should be considered in the differential diagnosis of ovine respiratory disease.
[Mh] Termos MeSH primário: Dispneia/veterinária
Enfisema Mediastínico/veterinária
Envenenamento/veterinária
Doenças dos Ovinos/induzido quimicamente
Doenças dos Ovinos/diagnóstico
Doenças dos Ovinos/patologia
Trema/toxicidade
[Mh] Termos MeSH secundário: Animais
Brasil
Diagnóstico Diferencial
Dispneia/induzido quimicamente
Dispneia/patologia
Evolução Fatal
Pulmão/patologia
Enfisema Mediastínico/induzido quimicamente
Enfisema Mediastínico/patologia
Plantas Tóxicas/efeitos adversos
Envenenamento/diagnóstico
Envenenamento/patologia
Ovinos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1404
[Cu] Atualização por classe:130909
[Lr] Data última revisão:
130909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130219
[St] Status:MEDLINE
[do] DOI:10.1177/0300985813478208


  7 / 20 MEDLINE  
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Langenbach, Tomaz
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[PMID]:22494373
[Au] Autor:Bicalho ST; Langenbach T
[Ad] Endereço:Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. simonetaketa@yahoo.com.br
[Ti] Título:Distribution of the herbicide atrazine in a microcosm with riparian forest plants.
[So] Source:J Environ Sci Health B;47(6):505-11, 2012.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pesticides applied on sugarcane reach the subsoil of riparian forests and probably contaminate the river water. This work was conducted to learn about the phytoremediation of atrazine and subsoil contamination using the common riparian forest species of Cecropia hololeuca Miq. and Trema micranta (L.) Blum. These plants were grown in soil microcosms where (14)C-atrazine at 1/10 of the field-recommended dose was applied at the bottom of the microcosm simulating the movement from contaminated ground water to the upper soil layers and into plants. Residues of (14)C-atrazine were detected in all parts of the microcosm including soil, rhizosphere and the roots in different layers of the microcosm, stem and leaves. Atrazine mineralization was higher (10.2%) in the microcosms with plants than the control microcosms without plants (1.2%). The upward movement of this pesticide from deeper to more superficial soil layers occurred in all the microcosms with plants, powered by evapotranspiration process. From the atrazine applied in this study about 45% was taken up by C. hololeuca and 35% by T. micrantha. The highest amount of radioactivity (%) was found in the fine roots and the specific radioactivity (% g(-1)) showed that thick, fine roots and leaves bioaccumulate atrazine. The enhanced mineralization of atrazine as well the phytostabilization effect of the tree biomass will reduce the bioavailability of these residues and consequently decrease the hazardous effects on the environment.
[Mh] Termos MeSH primário: Atrazina/metabolismo
Cecropia (Planta)/metabolismo
Recuperação e Remediação Ambiental/métodos
Herbicidas/metabolismo
Poluentes do Solo/metabolismo
Árvores/metabolismo
Trema/metabolismo
[Mh] Termos MeSH secundário: Atrazina/análise
Biodegradação Ambiental
Herbicidas/análise
Raízes de Plantas/metabolismo
Poluentes do Solo/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Herbicides); 0 (Soil Pollutants); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120413
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2012.665659


  8 / 20 MEDLINE  
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[PMID]:21491905
[Au] Autor:Kakar S; Sturms R; Tiffany A; Nix JC; DiSpirito AA; Hargrove MS
[Ad] Endereço:Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA.
[Ti] Título:Crystal structures of Parasponia and Trema hemoglobins: differential heme coordination is linked to quaternary structure.
[So] Source:Biochemistry;50(20):4273-80, 2011 May 24.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemoglobins from the plants Parasponia andersonii (ParaHb) and Trema tomentosa (TremaHb) are 93% identical in primary structure but differ in oxygen binding constants in accordance with their distinct physiological functions. Additionally, these proteins are dimeric, and ParaHb exhibits the unusual property of having different heme redox potentials for each subunit. To investigate how these hemoglobins could differ in function despite their shared sequence identity and to determine the cause of subunit heterogeneity in ParaHb, we have measured their crystal structures in the ferric oxidation state. Furthermore, we have made a monomeric ParaHb mutant protein (I43N) and measured its ferrous/ferric heme redox potential to test the hypothesized link between quaternary structure and heme heterogeneity in wild-type ParaHb. Our results demonstrate that TremaHb is a symmetric dimeric hemoglobin similar to other class 1 nonsymbiotic plant hemoglobins but that ParaHb has structurally distinct heme coordination in each of its two subunits that is absent in the monomeric I43N mutant protein. A mechanism for achieving structural heterogeneity in ParaHb in which the Ile(101(F4)) side chain contacts the proximal His(105(F8)) in one subunit but not the other is proposed. These results are discussed in the context of the evolution of plant oxygen transport hemoglobins, and other potential functions of plant hemoglobins.
[Mh] Termos MeSH primário: Heme/química
Hemoglobinas/química
Proteínas de Plantas/química
Estrutura Quaternária de Proteína
Trema
[Mh] Termos MeSH secundário: Transporte Biológico
Cristalografia por Raios X
Hemoglobinas/genética
Hemoglobinas/metabolismo
Modelos Moleculares
Mutagênese Sítio-Dirigida
Oxirredução
Oxigênio/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Subunidades Proteicas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Plant Proteins); 0 (Protein Subunits); 42VZT0U6YR (Heme); S88TT14065 (Oxygen)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110416
[St] Status:MEDLINE
[do] DOI:10.1021/bi2002423


  9 / 20 MEDLINE  
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[PMID]:21297345
[Au] Autor:Hong CE; Lyu SY
[Ti] Título:Genotoxicity detection of five medicinal plants in Nigeria.
[So] Source:J Toxicol Sci;36(1):87-93, 2011 Jan.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study was performed to investigate the safety of Alchornea cordifolia, Cnestis ferruginea, Lonchocarpus sericeus, Trema orientalis, and Senna alata in respect to genotoxicity. These five medicinal plants are widely distributed in Africa. They are used as a traditional medicine in many African counties for the treatment of microbial, inflammatory, and stress-related diseases. To evaluate the bacterial reverse mutation of these five medicinal plants, the in vitro Ames test using Salmonella typhimurium TA98, TA100, TA1535, and TA1537, and Escherichia coli WP2uvrA, with or without the addition of S9 mixture was performed. Concentrations used for this test were 625, 2,500, and 5,000 µg per plate. A. cordifolia, C. ferruginea, L. sericeus, and T. orientalis showed negative results in the bacterial reverse mutation test, suggesting that it is potentially safe for these plants to be used in medicinal plants supplements at high doses. However, our experiments suggest that S. alata is a potent mutagen. Therefore, further studies are needed to evaluate the carcinogenicity of S. alata in order to adequately assess the risks for human health.
[Mh] Termos MeSH primário: Connaraceae
Derris
Euphorbiaceae
Testes de Mutagenicidade/métodos
Extratos Vegetais/toxicidade
Senna (Planta)
Trema
[Mh] Termos MeSH secundário: Escherichia coli/efeitos dos fármacos
Seres Humanos
Nigéria
Salmonella typhimurium/efeitos dos fármacos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:110721
[Lr] Data última revisão:
110721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110208
[St] Status:MEDLINE


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[PMID]:20636784
[Au] Autor:Bandarra PM; Pavarini SP; Raymundo DL; Corrêa AM; Pedroso PM; Driemeier D
[Ad] Endereço:Departmento de Patologia Clínica, Faculdade de Veterinária, UFRGS. Porto Alegre-RS, Brazil.
[Ti] Título:Trema micrantha toxicity in horses in Brazil.
[So] Source:Equine Vet J;42(5):456-9, 2010 Jul.
[Is] ISSN:0425-1644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:After ingesting green leaves of T. micrantha, 2 horses showed apathy, locomotor deficit, blindness, recumbency, paddling, coma and death. The main gross findings were scattered haemorrhages, enhanced lobular pattern of the liver, and cerebral oedema. Histological changes included disseminated haemorrhages, massive hepatocellular necrosis, neuronal degeneration, Alzheimer type II astrocytes and cerebral perivascular oedema. Clinicopathological findings which were comparable with those observed in Trema micrantha poisoned ruminants, associated with epidemiological evidence suggested the diagnosis.Trema micrantha poisoning should be evaluated as a possible cause in the diagnosis of equine hepatopathy and occasional secondary encephalopathy.
[Mh] Termos MeSH primário: Doenças dos Cavalos/induzido quimicamente
Intoxicação por Plantas/veterinária
Plantas Tóxicas/efeitos adversos
Trema/química
[Mh] Termos MeSH secundário: Animais
Brasil/epidemiologia
Cerebelo/efeitos dos fármacos
Cerebelo/patologia
Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/patologia
Cavalos
Insônia Familiar Fatal
Fígado/efeitos dos fármacos
Fígado/patologia
Folhas de Planta/química
Intoxicação por Plantas/epidemiologia
Intoxicação por Plantas/patologia
Ponte/efeitos dos fármacos
Ponte/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1008
[Cu] Atualização por classe:100719
[Lr] Data última revisão:
100719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100720
[St] Status:MEDLINE
[do] DOI:10.1111/j.2042-3306.2010.00035.x



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