Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.110 [Categoria DeCS]
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  1 / 43 MEDLINE  
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[PMID]:28009846
[Au] Autor:Parra Pessoa I; Lopes Neto JJ; Silva de Almeida T; Felipe Farias D; Vieira LR; Lima de Medeiros J; Augusti Boligon A; Peijnenburg A; Castelar I; Fontenele Urano Carvalho A
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60020-181 Fortaleza, CE, Brazil. igorppessoa@gmail.com.
[Ti] Título:Polyphenol Composition, Antioxidant Activity and Cytotoxicity of Seeds from Two Underexploited Wild Licania Species: L. rigida and L. tomentosa.
[So] Source:Molecules;21(12), 2016 Dec 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Studies have shown the benefit of antioxidants in the prevention or treatment of human diseases and promoted a growing interest in new sources of plant antioxidants for pharmacological use. This study aimed to add value to two underexploited wild plant species ( and ) from Brazilian flora. Thus, the phenolic compounds profile of their seed ethanol extract and derived fractions were elucidated by HPLC, the antioxidant capacity was assessed by in vitro chemical tests and the cytotoxicity determined using the human carcinoma cell lines MCF-7 and Caco-2. Eleven phenolic compounds were identified in the extracts of each species. The extracts and fractions showed excellent antioxidant activity in the DPPH assay (SC , ranging from 9.15 to 248.8 µg/mL). The aqueous fraction of seeds was most effective in preventing lipid peroxidation under basal conditions (IC 60.80 µg/mL) whereas, in the presence of stress inducer, the methanolic fraction of performed best (IC 8.55 µg/mL). None of the samples showed iron chelating capacity. Ethanolic seed extracts of both species did not reveal any cytotoxicity against MCF-7 and Caco-2 cells. Both plant species showed a promising phenolic profile with potent antioxidant capacity and deserve attention to be sustainably explored.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Chrysobalanaceae/química
Flavonoides/farmacologia
Fenóis/farmacologia
Sementes/química
Taninos/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/antagonistas & inibidores
Células CACO-2
Sobrevivência Celular/efeitos dos fármacos
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Células MCF-7
Metanol/química
Fenóis/química
Fenóis/isolamento & purificação
Picratos/antagonistas & inibidores
Extratos Vegetais/química
Solventes/química
Taninos/química
Taninos/isolamento & purificação
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 0 (Tannins); 0 (Thiobarbituric Acid Reactive Substances); 059QF0KO0R (Water); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE


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[PMID]:27549624
[Au] Autor:Gororo M; Chimponda T; Chirisa E; Mukanganyama S
[Ad] Endereço:School of Pharmacy, College of Health Sciences, University of Zimbabwe, Mt. Pleasant, Harare, Zimbabwe.
[Ti] Título:Multiple cellular effects of leaf extracts from Parinari curatellifolia.
[So] Source:BMC Complement Altern Med;16(1):305, 2016 Aug 22.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parinari curatellifolia is a prominent plant in folk medicine in Sub-Saharan Africa. The plant decoctions are used to treat various ailments, including the treatment of cancer, pneumonia, fever, microbial infections and anti-inflammation. The aims of the study were to investigate the effects of P. curatellifolia leaf extracts on cell inflammatory and proliferative activity. METHODS: Parinari curatellifolia fresh leaves were collected from Centenary in Mashonaland Central Province of Zimbabwe. Plant extracts were prepared using methanol, water, acetone and ethanol. Firstly, the effects of the extracts were determined on xanthine oxidase activity. Kinetic constants were determined for the extracts that showed inhibitory effects. Then the effects of Parinari curatellifolia water extract on LPS, menadione and hydrogen peroxide-activated nitric oxide production in RAW 264.7 cells was determined by quantifying the amount of nitrites formed. Finally, the effects of P. curatellifolia on the proliferation of Jurkat-T cells as well as its modulation of cisplatin-induced cell- cytotoxicity was investigated on a Jurkat human T-cell lymphoma cell line. RESULTS: There was significant XO inhibitory activity by the ethanol and methanol extracts at 15.6 µg/ml and 3.9 µg/ml respectively. The IC50 determination for allopurinol, ethanol extract and methanol extract were 0.43 µg/ml, 1.38 µg/ml and 2.19 µg/ml respectively. The kinetic results showed that the ethanol and methanol extracts were allosteric inhibitors of XO. The water extract of P. curatellifolia inhibited NO production in RAW cells when LPS was used as an activator. P. curatellifolia and cisplatin showed dose-dependent cytotoxicity on Jurkat-T cells. Isolated DNA from the cells showed that there was DNA cleavage on cells exposed to P. curatellifolia indicating that apoptosis may be a mechanism by which P. curatellifolia exerts its cytotoxicity on Jurkat-T cells. CONCLUSIONS: These results scientifically support the use of P. curatellifolia leaf extracts in the management of pain, inflammatory and neoplastic conditions. P. curatellifolia thus has multiple biological effects, thus, validating its use in traditional medical uses.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Chrysobalanaceae/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Células Jurkat
Camundongos
Óxido Nítrico/metabolismo
Extratos Vegetais/química
Substâncias Protetoras/química
Células RAW 264.7
Xantina Oxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Protective Agents); 31C4KY9ESH (Nitric Oxide); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1287-6


  3 / 43 MEDLINE  
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Antunes, Lusânia Maria Greggi
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[PMID]:27494754
[Au] Autor:Venancio VP; Marques MC; Almeida MR; Mariutti LR; Souza VC; Barbosa F; Pires Bianchi ML; Marzocchi-Machado CM; Mercadante AZ; Antunes LM
[Ad] Endereço:a School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , São Paulo , Brazil.
[Ti] Título:Chrysobalanus icaco L. fruits inhibit NADPH oxidase complex and protect DNA against doxorubicin-induced damage in Wistar male rats.
[So] Source:J Toxicol Environ Health A;79(20):885-93, 2016.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chrysobalanus icaco L. is an underexplored plant found in tropical areas around the globe. Currently, there is no apparent information regarding the effects C. icaco fruits may exert in vivo or potential role in health promotion. This study aimed at providing evidence regarding the in vivo influence of this fruit on antigenotoxicity, antimutagenicity, and oxidative stress in rats. Male Wistar rats were treated with 100, 200, or 400 mg/kg body weight (bw)/d C. icaco fruit for 14 d. Doxorubicin (DXR, 15 mg/kg bw, ip) was used for DNA damaging and as an oxidant to generate reactive oxygen species (ROS). Genomic instability was assessed by the comet assay and micronucleus (MN) test, while antioxidant activity was determined by oxidative burst of neutrophils. Chrysobalanus icaco fruit polyphenols were quantified and characterized by high-performance liquid chromatography coupled to a diode array detector and tandem mass spectrometer (HPLC-DAD-MS/MS). The concentrations of 19 chemical elements were determined by inductively coupled plasma-mass spectroscopy (ICP-MS). Significant amounts of polyphenols, magnesium, and selenium were found in C. icaco fruit. This fruit displayed in vivo antioxidant activity against DXR-induced damage in rat peripheral blood neutrophils, antigenotoxicity in peripheral blood cells, and antimutagenicity in bone-marrow cells and peripheral blood cells. Correlation analyses between endpoints examined indicated that the mechanism underlying chemopreventive actions of C. icaco fruit was attributed to inhibition of NADPH oxidase complex manifested as low levels of DNA damage in animals exposed to DXR. Data indicate that phytochemicals and minerals in C. icaco fruit protect DNA against damage in vivo associated with their antioxidant properties.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Chrysobalanaceae/química
Dano ao DNA/efeitos dos fármacos
NADPH Oxidases/metabolismo
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Doxorrubicina/toxicidade
Frutas/química
Masculino
Substâncias Protetoras/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Protective Agents); 80168379AG (Doxorubicin); EC 1.6.3.- (NADPH Oxidases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2016.1193454


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[PMID]:27457758
[Au] Autor:Gweshelo D; Muswe R; Mukanganyama S
[Ad] Endereço:School of Pharmacy, College of Health Sciences, University of Zimbabwe, Mt. Pleasant, Harare, Zimbabwe.
[Ti] Título:In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae).
[So] Source:BMC Complement Altern Med;16:238, 2016 Jul 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parinari curatellifolia and Combretum zeyheri are medicinal plants used in Zimbabwe and other Southern African countries for stomach ailments, fever, body aches, wound healing, cancer and tuberculosis. Glutathione transferases (GSTs) are mammalian enzymes that play a significant role in the detoxification and metabolism of many xenobiotic and endogenous compounds and as such can interact with many exogenous compounds including herbal medicines. The effects of Parinari curatellifolia and Combretum zeyheri leaf extracts on glutathione transferases of male Sprague-Dawley rats were investigated in vivo and in vitro after oral administration of either leaf ethanol or water extracts of each plant. METHODS: For Parinari curatellifolia, 18 male Sprague-Dawley rats were administered with 0, 500 and 1000 mg/kg body weight of the leaf extracts in corn oil or saline. Animals were sacrificed after 96 h and the kidney and liver samples were removed and used to prepare the cytosolic fractions. GST activity was determined using 1-chloro-2, 4-dinitrobezene. For Combretum zeyheri, twenty four male Sprague-Dawley rats were randomly divided into two groups. These two groups were further divided into three groups of four animals each. They were given either the aqueous or ethanol extract at doses of C. zeyheri at 0, 50 mg/kg body weight and 200 mg/kg body weight. The extracts were administered orally by oral gavage for four consecutive days and the rats were sacrificed by cervical dislocation on the fifth day. RESULTS: In animals administered with C. zeyheri, GST activity was significantly increased by the 200 mg/kg aqueous extract in the kidneys and livers in vivo whilst the ethanolic extract at 200 mg/kg decreased enzyme activity significantly both organs. Both the ethanol and aqueous extracts inhibited GST activity in vitro with the ethanol extract being more potent inhibitor than ethacrynic acid, a standard GST inhibitor. The increased GST activity in vivo and versus inhibition in vitro suggests that metabolites may be responsible for the effects observed in vivo. For P. curatellifolia, a dose-dependent decrease in GST activity was observed in vivo for the animals given the aqueous extract but no changes were observed with the ethanol extract. There was a concentration-dependent inhibition of cytosolic GSTs when P. curatellifolia leaf extracts in vitro. The ethanol extract of P. curatellifolia exhibited GST-inhibitory activity in the liver with an IC50 value of 12 µg/mL and for ethacrynic acid, the IC50 was found to be 10 µg/mL. This showed that this extract was a potent inhibitor of GSTs in vitro. CONCLUSIONS: C. zeyheri had an inductive effect on GST activity when administered in aqueous solution but inhibited GST in vitro whilst P. curatellifolia inhibited GST activity in vivo. Induction of GSTs would be cytoprotective against the toxic effects electrophilic chemicals. Since GSTs are responsible for the synthesis of prostaglandins, the inhibition of GST activity of by these two plants in vivo maybe one of the reasons that makes the plants important for use in the treatment pain and fever in ethnopharmacology.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Chrysobalanaceae/química
Combretum/química
Glutationa Transferase/antagonistas & inibidores
Fígado/enzimologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Folhas de Planta/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1235-5


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[PMID]:27329943
[Au] Autor:Bardon L; Sothers C; Prance GT; Malé PJ; Xi Z; Davis CC; Murienne J; García-Villacorta R; Coissac E; Lavergne S; Chave J
[Ad] Endereço:Laboratoire Evolution et Diversité Biologique UMR 5174 CNRS, ENFA, Université Paul Sabatier 31062 Toulouse, France.
[Ti] Título:Unraveling the biogeographical history of Chrysobalanaceae from plastid genomes.
[So] Source:Am J Bot;103(6):1089-102, 2016 06.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: The complex geological and climatic history of the Neotropics has had major implications on the diversification of plant lineages. Chrysobalanaceae is a pantropical family of trees and shrubs with 75% of its 531 species found in the Neotropics, and a time-calibrated phylogeny of this family should shed light on the tempo of diversification in the Neotropical flora. Previously published phylogenetic hypotheses of this family were poorly supported, and its biogeography remains unclear. METHODS: We assembled the complete plastid genome of 51 Chrysobalanaceae species, and increased taxon sampling by Sanger-sequencing of five plastid regions for an additional 88 species. We generated a time-calibrated tree including all 139 Chrsyobalanaceae species and 23 outgroups. We then conducted an ancestral area reconstruction analysis and estimated diversification rates in the family. KEY RESULTS: The tree generated with the plastid genome alignment was almost fully resolved. It supports the polyphyly of Licania and Hirtella. The family has diversified starting around the Eocene-Oligocene transition. An ancestral area reconstruction confirms a Paleotropical origin for Chrysobalanaceae with several transoceanic dispersal events. The main Neotropical clade likely resulted from a single migration event from Africa around 28 mya ago, which subsequently underwent rapid diversification. CONCLUSIONS: Given the diverse ecologies exhibited by extant species, we hypothesize that the rapid diversification of Chrysobalanaceae following the colonization of the Neotropics was triggered by habitat specialization during the complex geological and paleoclimatic history of the Neotropics.
[Mh] Termos MeSH primário: Chrysobalanaceae/classificação
Chrysobalanaceae/genética
Genomas de Plastídeos
Filogeografia
[Mh] Termos MeSH secundário: Sequência de Bases
Extinção Biológica
Especiação Genética
Variação Genética
Filogenia
Análise de Sequência de DNA
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1500463


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[PMID]:27319132
[Au] Autor:Adjapmoh MF; Toze FA; Songue JL; Langat MK; Kapche GD; Hameed A; Lateef M; Shaiq MA; Mbaze LM; Wansi JD; Kamdem AF
[Ti] Título:A New Ceramide and Biflavonoid from the Leaves of Parinari hypochrysea (Chrysobalanaceae).
[So] Source:Nat Prod Commun;11(5):615-20, 2016 May.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new ceramide and a new biflavonoid named parinaramide (1) and sparinaritin (2), respectively, have been isolated along with ten known compounds, kaempferol, quercetin, taxifolin, taxifolin-3-O-rhamnoside, lupeol, betulinic acid, ursolic acid, 2α-hydroxy-ursolic acid, 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone, and sucrose, from the leaves of Parinari hypochrysea (Chrysobalanaceae). Structures were determined using 1D- and 2D-NMR, MS and by chemical analysis. The methanol extract of leaves, stem bark and roots of P. hypochrysea were screened for their antioxidant and lipoxygenase inhibition potential and found to be inactive.
[Mh] Termos MeSH primário: Biflavonoides/isolamento & purificação
Ceramidas/isolamento & purificação
Chrysobalanaceae/química
[Mh] Termos MeSH secundário: Biflavonoides/química
Ceramidas/química
Estrutura Molecular
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Ceramides); 0 (parinaramide); 0 (sparinaritin)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160620
[Lr] Data última revisão:
160620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:26865122
[Au] Autor:Jud NA; Nelson CW; Herrera F
[Ad] Endereço:Florida Museum of Natural History, University of Florida, Gainesville, Florida 32611 USA najud@flmnh.ufl.edu.
[Ti] Título:Fruits and wood of Parinari from the early Miocene of Panama and the fossil record of Chrysobalanaceae.
[So] Source:Am J Bot;103(2):277-89, 2016 Feb.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Chrysobalanaceae are woody plants with over 500 species in 20 genera. They are among the most common trees in tropical forests, but a sparse fossil record has limited our ability to test evolutionary and biogeographic hypotheses, and several previous reports of Chrysobalanaceae megafossils are doubtful. METHODS: We prepared fossil endocarps and wood collected from the lower Miocene beds along the Panama Canal using the cellulose acetate peel technique and examined them using light microscopy. We compared the fossil endocarps with previously published fossils and with fruits from herbarium specimens. We compared the fossil wood with photographs and descriptions of extant species. KEY RESULTS: Parinari endocarps can be distinguished from other genera within Chrysobalanaceae by a suite of features, i.e., thick wall, a secondary septum, seminal cavities lined with dense, woolly trichomes, and two ovate to lingulate basal germination plugs. Fossil endocarps from the Cucaracha, Culebra, and La Boca Formations confirm that Parinari was present in the neotropics by the early Miocene. CONCLUSIONS: The earliest unequivocal evidence of crown-group Chrysobalanaceae is late Oligocene-early Miocene, and the genus Parinari was distinct by at least 19 million years ago. Parinari and other Chrysobalanaceae likely reached the neotropics via long-distance dispersal rather than vicariance. The presence of Parinari in the Cucaracha flora supports the interpretation of a riparian, moist tropical forest environment. Parinari was probably a canopy-dominant tree in the Cucaracha forest and took advantage of the local megafauna for seed dispersal.
[Mh] Termos MeSH primário: Chrysobalanaceae/anatomia & histologia
Meio Ambiente
Fósseis/anatomia & histologia
Dispersão Vegetal
[Mh] Termos MeSH secundário: Evolução Biológica
Chrysobalanaceae/classificação
Frutas/anatomia & histologia
Panamá
Madeira/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160218
[Lr] Data última revisão:
160218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1500425


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[PMID]:26854845
[Au] Autor:White PA; Araújo JM; Cercato LM; Souza LA; Barbosa AP; Quintans-Junior LJ; Machado UF; Camargo EA; Brito LC; Santos MR
[Ad] Endereço:1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
[Ti] Título:Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.
[So] Source:J Med Food;19(2):155-60, 2016 Feb.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chrysobalanus icaco L. is a medicinal plant present in the Brazilian coastline and known for its hypoglicemic and antioxidant properties. Here, we assessed the beneficial metabolic effects of the aqueous extract of C. icaco (AECI) leaves in diet-induced obese mice. Swiss mice were fed standard chow (SC used as controls) or high-fat diet (HFD) to induce obesity. After 10 weeks, mice on each diet were divided into two groups with one group used as control while the other group treated with AECI for 4 weeks resulting in four groups of mice: SC; SC treated with AECI (SC + AECI); HFD; and HFD treated with AECI (HFD + AECI). AECI was administered drinking water at about 200 mg/kg. AECI was able to normalize insulin (13,682 ± 1090 vs. 9828 ± 485 AU, P < .05) and fasting blood glucose (192.8 ± 14.2 vs. 132.3 ± 6.4 mg/dL, P < .05) and inhibit weight gain (39 ± 5.7%) and fat storage in liver (72.60 ± 3.83%, P < .0001), despite the high-fat intake. These findings reinforce the use of AECI in hyperglycemia and highlight the potential extract's effect in preventing weight gain and fat accumulation in liver of diet-induced obese mice.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Chrysobalanaceae/química
Resistência à Insulina
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Alanina Transaminase/sangue
Animais
Antioxidantes/farmacologia
Aspartato Aminotransferases/sangue
Peso Corporal
Brasil
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Creatinina/sangue
Dieta Hiperlipídica
Teste de Tolerância a Glucose
Insulina/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Obesos
Obesidade/tratamento farmacológico
Triglicerídeos/sangue
Ureia/sangue
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Insulin); 0 (Plant Extracts); 0 (Triglycerides); 8W8T17847W (Urea); AYI8EX34EU (Creatinine); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160209
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2015.0034


  9 / 43 MEDLINE  
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[PMID]:26723470
[Au] Autor:White PA; Cercato LM; Batista VS; Camargo EA; De Lucca W; Oliveira AS; Silva FT; Goes TC; Oliveira ER; Moraes VR; Nogueira PC; De Oliveira E Silva AM; Quintans-Junior LJ; Lima BS; Araújo AA; Santos MR
[Ad] Endereço:Department of Physiology, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil. Electronic address: pollyannawhite@gmail.com.
[Ti] Título:Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice.
[So] Source:J Ethnopharmacol;179:92-100, 2016 Feb 17.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Due to the rise in obesity, the necessity for resources and treatments that could reduce the morbidity and mortality associated to this pandemia has emerged. The development of new anti-obesity drugs through herbal sources has been increasing in the past decades which are being used not only as medicine but also as food supplements. Previous studies with the aqueous extract of Chrysobalanus icaco L (AECI) have demonstrated activity on lowering blood glucose levels and body weight. AIM OF THE STUDY: Investigate C. icaco effects in overall adiposity and glycemic homeostasis. MATERIAL AND METHODS: C57BL/6J mice were randomly assigned to standard chow (SC) or high-fat diet (HFD) and treated with AECI in 0.35mg/mL or 0.7mg/mL concentrations ad libitum. Food intake, feed efficiency, metabolic efficiency, body, fat pads and gastrocnemius weight, adiposity index, serum lipids, fecal lipid excretion, locomotor activity in the open field test and insulin and glucose tolerance tests were analyzed and compared. The major components of the extract were demonstrated through HPLC and its antioxidant activity analyzed through DPPH and lipid peroxidation. RESULTS: The AECI in the 0.35mg/mL concentration did not affect food intake or body weight. However, it promoted lower adipose tissue gain, TG levels, and fecal lipid excretion, increased locomotor activity and lean mass weight, and normalized insulin sensitivity and glucose tolerance. Moreover, AECI showed the presence of myricetin 3-O-glucuronide, rutin, quercitrin and myricitrin and demonstrated high-antioxidant activity. CONCLUSIONS: AECI in lower concentrations can prevent fat storage or enhance fat utilization through the increase of locomotor activity. Also, this reinforces its ability to maintain glucose homeostasis through the normalization of insulin sensitivity and glucose tolerance despite the high-fat diet intake. These activities could be associated to the extract's polyphenol content.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/uso terapêutico
Chrysobalanaceae/química
Dieta Hiperlipídica
Obesidade/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Depuradores de Radicais Livres/farmacologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Atividade Motora/efeitos dos fármacos
Obesidade/patologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Blood Glucose); 0 (Free Radical Scavengers); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160103
[St] Status:MEDLINE


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[PMID]:26211429
[Au] Autor:Berto A; Ribeiro AB; Sentandreu E; de Souza NE; Mercadante AZ; Chisté RC; Fernandes E
[Ad] Endereço:Postgraduate Program of Chemistry, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
[Ti] Título:The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts.
[So] Source:Food Funct;6(9):3081-90, 2015 Sep.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For the first time, the phenolic compounds and carotenoids in extracts obtained from the pulp, shell and seeds of C. bracteosa fruits are reported, as well as their in vitro scavenging capacities against some reactive oxygen species (ROS) and reactive nitrogen species (RNS). The shell extract presented the highest phenolic compound and carotenoid contents (5540 and 328 µg per g extract, dry basis, respectively), followed by the pulp and seed extracts. The major phenolic compound was acacetin sulphate (one methoxy and two OH groups) (62%) in the shells; however, only seeds presented apigenin sulphate (three OH groups), in which it was the major compound (44%). The high content of apigenin sulphate may explain why the seed extract had the highest scavenging efficiency against all tested ROS/RNS among the studied extracts. Regarding carotenoids, all-trans-neochrome (17%) and all-trans-ß-carotene (16%) were the major carotenoids in the pulp extracts, while all-trans-lutein (44%) was the most prevalent in the shell extracts and all-trans-α-carotene (32%) and all-trans-ß-carotene (29%) were the major ones in the seed extracts.
[Mh] Termos MeSH primário: Chrysobalanaceae/química
Depuradores de Radicais Livres/química
Frutas/química
Extratos Vegetais/química
Espécies Reativas de Nitrogênio/química
Espécies Reativas de Oxigênio/química
Sementes/química
[Mh] Termos MeSH secundário: Espectrometria de Massas
Estrutura Molecular
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Reactive Nitrogen Species); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150903
[Lr] Data última revisão:
150903
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00722d



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