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Pesquisa : B01.650.940.800.575.912.250.859.937.222 [Categoria DeCS]
Referências encontradas : 30 [refinar]
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[PMID]:28500228
[Au] Autor:Jud NA; Nelson CW
[Ad] Endereço:L.H. Bailey Hortorium, Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, New York 14853, USA nathan.jud@cornell.edu.
[Ti] Título:A liana from the lower Miocene of Panama and the fossil record of Connaraceae.
[So] Source:Am J Bot;104(5):685-693, 2017 May.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Permineralized wood is common in the Miocene beds exposed during the expansion of the Panama Canal. We describe a stem with the distinctive anatomy of a liana and evaluate the evolutionary, biogeographic, and ecological significance of this discovery. METHODS: The object of the study was obtained from a collection of fossil woods and fruits from a locality in the lower Miocene Cucaracha Formation, where the formation is exposed by the Culebra Cut of the Panama Canal. Thin sections were prepared using the cellulose acetate peel technique and examined using transmitted light microscopy. We described the anatomy and compared it with that of extant and fossil species. We also reviewed and evaluated published reports of fossils attributed to Connaraceae. KEY RESULTS: The anatomy of this fossil wood matches the genus (Connaraceae). The stem is only 1 cm in diameter, but vessels >200 µm in diameter also occur, indicating the perennial climbing habit. We evaluated 12 other pre-Quaternary occurrences attributed to Connaraceae. Four are accepted, three are rejected, and we consider five unknown or uncertain. CONCLUSIONS: The discovery of this stem confirms the presence of Connaraceae in the Neotropics by the early Miocene, provides the oldest evidence of the climbing habit in the family, and contributes to our understanding of the flora of Panama 19 mya. Although the fossil record of Connaraceae is sparse, reliable occurrences span three continents and indicate that the family originated as early as the Late Cretaceous-Paleocene and was widespread by the early Miocene.
[Mh] Termos MeSH primário: Evolução Biológica
Connaraceae/classificação
Filogenia
[Mh] Termos MeSH secundário: Fósseis
Panamá
Caules de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1700080


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[PMID]:27399811
[Au] Autor:Ishola IO; Akinleye MO; Oduola MD; Adeyemi OO
[Ad] Endereço:Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, PMB 12003, Idi-araba, Lagos, Nigeria.
[Ti] Título:Roles of monoaminergic, antioxidant defense and neuroendocrine systems in antidepressant-like effect of Cnestis ferruginea Vahl ex DC (Connaraceae) in rats.
[So] Source:Biomed Pharmacother;83:340-348, 2016 Oct.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:We have earlier reported antidepressant-like effect of Cnestis ferruginea and its bioflavonoid constituent, amentoflavone in behavioural paradigms but its effects on neurochemical and neuroendocrine systems are yet to be elucidated. This study sought to investigate the effect of subchronic treatment of C. ferruginea (CF) on monoamines system, hypothalamo-pituitary adrenal axis and nitrosative/oxidative stresses. Male albino rats (150-200g) randomly divided into seven groups; Group I: vehicle treated (0.2% / Tween 80 in normal saline (10ml/kg; p.o.; unstressed), Group II: vehicle treated+restraint stress, Group III: imipramine (20mg/kg; p.o.), Group IV-VI: CF (12.5, 50, or 100mg/kg; p.o., respectively), Group VII: CF 6.25+imipramine 5mg/kg. One hour post-treatment, animals were subjected to 20min restraint stress and 6min, forced swim test (FST) for a period of 14 days. CF (12.5, 50 and 100mg/kg) produced significant reduction in immobility time and an increase in climbing behaviour. CF attenuated repeated restraint stress×FST-induced serum corticosterone [F(6,28)=5.45,P<0.01]. Exposure of rats to FST+restraint stress paradigms produced significant (P<0.05) increase in malondialdehyde and nitrite level, also reduced the glutathione level and superoxide dismutase activity which was reversed by subchronic treatment of rats with CF. Restraint stress×FST significantly decreased NA, DA and 5-HT concentrations, with increased DA and 5-HT turnover ratios in discrete brain regions which was ameliorated by CF or imipramine subchronic treatment. These results suggest that the antidepressant-like effect of C. ferruginea involved enhancement of monoamines and antioxidant as well as normalization of neuroendocrine systems.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Antioxidantes/metabolismo
Monoaminas Biogênicas/metabolismo
Connaraceae/química
Sistemas Neurossecretores/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Corticosterona/sangue
Masculino
Metaboloma/efeitos dos fármacos
Sistemas Neurossecretores/efeitos dos fármacos
Neurotransmissores/metabolismo
Nitrosação
Estresse Oxidativo/efeitos dos fármacos
Raízes de Plantas/química
Ratos Sprague-Dawley
Natação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Antioxidants); 0 (Biogenic Monoamines); 0 (Neurotransmitter Agents); 0 (Plant Extracts); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


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[PMID]:26940897
[Au] Autor:Silva TP; Moura VM; Souza MC; Santos VN; Silva KA; Mendes MG; Nunez CV; Almeida PD; Lima ES; Mourão RH; Dos-Santos MC
[Ad] Endereço:Programa Multi-Institucional de Pós-graduação em Biotecnologia, Laboratório de Imunoquímica, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, AM, Brazil; Laboratório de Imunoquímica, Departamento de Parasitologia, Instituto de Ciências Biológ
[Ti] Título:Connarus favosus Planch.: An inhibitor of the hemorrhagic activity of Bothrops atrox venom and a potential antioxidant and antibacterial agent.
[So] Source:J Ethnopharmacol;183:166-75, 2016 May 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The plant species Connarus favosus is used in folk medicine in the west of Pará state, Brazil, to treat snakebites. AIM OF THE STUDY: To investigate the potential of the aqueous extract of Connarus favosus (AECf) to inhibit hemorrhagic and phospholipase A2 activities induced by Bothrops atrox venom (BaV) and to determine the antioxidant and antimicrobial potentials of the extract. MATERIALS AND METHODS: AECf was analyzed phytochemically for phenolics (condensed tannins and hydrolyzable tannins) by colorimetry. Antioxidant activity was evaluated by quantitative assays using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Fe(3+)/phenanthroline. Antimicrobial activity was evaluated by the minimal inhibitory concentration test, and cytotoxicity was evaluated using human fibroblast cells (MRC-5). Inhibition of BaV-induced hemorrhagic activity was assessed after oral administration of the extract using pre-treatment, post-treatment and combined (BA plus AECf) treatment protocols. Inhibition of indirect hemolysis caused by phospholipase A2 (PLA2) was investigated in vitro. Interaction between AECf and BaV was investigated by SDS-PAGE electrophoresis, Western blot (Wb) and zymography. RESULTS: The phytochemical profile of AECf revealed ten secondary metabolite classes, and colorimetry showed high total phenolic and total (condensed and hydrolyzable) tannin content. AECf exhibited high antioxidant and antimicrobial potentials. The IC50 for the cytotoxic effect was 51.91 (46.86-57.50)µg/mL. Inhibition of BaV-induced hemorrhagic activity was significant in all the protocols, and inhibition of PLA2 activity was significant with the two highest concentrations. The BaV/AECf mixture produced the same bands as BaV by itself in SDS-PAGE and Wb although the bands were much fainter. Zymography confirmed the proteolytic activity of BaV, but when the venom was pre-incubated with AECf this activity was blocked. CONCLUSION: AECf was effective in reducing BaV-induced hemorrhagic activity when administered by the same route as that used in folk medicine and exhibited antioxidant and antimicrobial potentials.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antivenenos/farmacologia
Connaraceae/química
Venenos de Crotalídeos/administração & dosagem
Hemorragia/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antioxidantes/farmacologia
Antivenenos/química
Bothrops
Brasil
Feminino
Hemorragia/metabolismo
Masculino
Medicina Tradicional/métodos
Camundongos
Fosfolipases A2/metabolismo
Compostos Fitoquímicos/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/química
Mordeduras de Serpentes/tratamento farmacológico
Taninos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Antivenins); 0 (Crotalid Venoms); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Tannins); EC 3.1.1.4 (Phospholipases A2)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE


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[PMID]:26789652
[Au] Autor:Owope TE; Ishola IO; Akinleye MO; Oyebade R; Adeyemi OO
[Ad] Endereço:Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Science, College of Medicine, University of Lagos, Lagos, Nigeria.
[Ti] Título:Antidepressant Effect of Cnestis ferruginea Vahl ex DC (Connaraceae): Involvement of Cholinergic, Monoaminergic and L-arginine-nitric Oxide Pathways.
[So] Source:Drug Res (Stuttg);66(5):235-45, 2016 May.
[Is] ISSN:2194-9387
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We have previously reported antidepressant effect of Cnestis ferruginea (CF) in behavioral models of depression. Due to the promise shown by this extract, this study was carried out to investigate the contribution of monoaminergic, cholinergic and nitrergic systems to the antidepressant-like effect elicited by CF. METHODS: Male albino mice were pretreated with monoaminergic or cholinergic receptor antagonists, L-arginine or N(G)-nitro-L-arginine (nitric oxide synthase inhibitor) (at doses reported to block the in vivo effect of the agonists), 15 min before oral administration of CF (100 mg/kg), 1 h later, the forced swim test (FST) in mice was carried out. RESULTS: CF treatment produced significant changes in the duration of swimming (F(5,42)=9.86, P<0.001), climbing behaviour (F(5,42)=4.51, P=0.004) and mean time spent immobile (F(5,42)=11.55, P<0.001) vs. vehicle-treated control. Co-administration of CF with fluoxetine or imipramine potentiated their effect. However, pretreatment of mice with reserpine (F(1,16)=119.20, P<0.001), prazosin (F(1,16)=68.98, P<0.001), sulpiride (F(1,16)=15.46, P<0.01), RS 127445 ((F(1,20)=8.22, P<0.01), SB 399885 ((F(1,20)=38.44, P<0.001), atropine (F(1,16)=53.77, P<0.001), or L-arginine (nitric oxide precursor) (F(1,16)=10.35, P<0.01) prevented CF-induced antidepressant-like effect in mice. In addition, pretreatment of mice with L-NNA (10 mg/kg) augmented the effect of CF. CONCLUSION: C. ferruginea exerts its antidepressant-like action through interaction with α-adrenoceptor, dopamine D2, 5-HT2B, 5-HT6 and muscarinic cholinergi1c receptors as well as L-arginine-nitric oxide systems. C. ferruginea could be used as adjuvant with conventional antidepressants in the treatment of major depressive disorder.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Connaraceae/química
Depressão/tratamento farmacológico
Medicina Tradicional Africana/métodos
Extratos Vegetais/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antidepressivos/uso terapêutico
Arginina/metabolismo
Arginina/farmacologia
Comportamento Animal/efeitos dos fármacos
Antagonistas Colinérgicos/farmacologia
Modelos Animais de Doenças
Masculino
Camundongos
Atividade Motora/efeitos dos fármacos
Nigéria
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase/antagonistas & inibidores
Nitroarginina/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Ratos Sprague-Dawley
Receptores Colinérgicos/metabolismo
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Cholinergic Antagonists); 0 (Plant Extracts); 0 (Receptors, Cholinergic); 2149-70-4 (Nitroarginine); 31C4KY9ESH (Nitric Oxide); 94ZLA3W45F (Arginine); EC 1.14.13.39 (Nitric Oxide Synthase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160121
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1565174


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Almeida, Maria das Gracas
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[PMID]:24800671
[Au] Autor:Kalegari M; Gemin CA; Araújo-Silva G; Brito NJ; López JA; Tozetto Sde O; Almeida Md; Miguel MD; Stien D; Miguel OG
[Ad] Endereço:Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brazil; Institut de Chimie de Substances Naturelles, CNRS, Gif-sur-Yvette, France.
[Ti] Título:Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats.
[So] Source:Nutrition;30(6):713-8, 2014 Jun.
[Is] ISSN:1873-1244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to evaluate the flavonoid content of an ethanolic leaf extract from the medicinal plant Rourea induta Planch. (RIEE) and to investigate its hepatoprotective potential and in vivo antioxidant effects. METHODS: Using samples from carbon tetrachloride-treated Wistar female rats treated orally with or without RIEE, we evaluated the aspartate aminotransferase, alanine aminotransferase, and total bilirubin levels in plasma; the levels of the hepatic oxidative stress markers catalase, superoxide dismutase, glutathione peroxidase, and reduced glutathione in liver homogenates; and the thiobarbituric acid reactive substance levels. A histopathology study was performed. A quantitative analysis of the RIEE extract was performed using high-performance liquid chromatography to evaluate its flavonoid content. RESULTS: Oral administration of RIEE significantly reduced carbon tetrachloride-induced elevations in the levels of plasma markers of hepatic damage and lipid peroxidation. It also rescued histopathologic alterations observed in the liver and levels of oxidative stress markers. CONCLUSIONS: RIEE exhibits antioxidant and hepatoprotective activities in vivo, which may be attributable to its flavonoids composition [hyperin (2), quercetin-3-O-ß-xyloside (4), quercetin-3-O-α-arabinofuranoside (5), and quercetin (6)].
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Connaraceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/química
Aspartato Aminotransferases/sangue
Bilirrubina/sangue
Catalase/metabolismo
Feminino
Flavonoides/química
Flavonoides/farmacologia
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Folhas de Planta/química
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances); CL2T97X0V0 (Carbon Tetrachloride); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140508
[St] Status:MEDLINE


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[PMID]:24680990
[Au] Autor:Kalegari M; Cerutti ML; Macedo-Júnior SJ; Bobinski F; Miguel MD; Eparvier V; Santos AR; Stien D; Miguel OG
[Ad] Endereço:Departamento de Farmácia, Setor de Ciências da Saúde, Universidade Federal do Paraná, Av. Prefeito Lothário Meissner, 632 Jardim Botânico, 80210-170 Curitiba, PR, Brazil; Institut de Chimie de Substances Naturelles, CNRS, 1 Avenue de La Terrasse, 91198 Gif-sur-Yvette, France.
[Ti] Título:Chemical composition and antinociceptive effect of aqueous extract from Rourea induta Planch. leaves in acute and chronic pain models.
[So] Source:J Ethnopharmacol;153(3):801-9, 2014 May 14.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Rourea induta Planch. is a small tree or shrub growing wild in Brazil and belonging to the Connaraceae family. It is used for the treatment of Chagas disease and as antirheumatic in folk medicine. This study was designed to investigate the antinociceptive activity of the aqueous extract (AERi) of Rourea induta leaves in rodents, as well as isolate and identify components that can be responsible for its effect. MATERIAL AND METHODS: The antinociceptive effect of orally administered AERi was evaluated in behavioral models of acute (formalin) and chronic [complete Freund׳s adjuvant (CFA)] pain in mice. We also investigated the possible involvement of opioid receptors and proinflammatory cytokines (interleukin-1ß and tumor necrosis factor-α) in the antinociceptive effect of the AERi. In addition, a nonspecific effect of AERi was evaluated by measuring locomotor activity and corporal temperature. Finally, we performed a phytochemical analysis of AERi. RESULTS: HPLC titration revealed the presence of hyperin (21.6 mg/g), quercetin-3-O-ß-xyloside (4.4 mg/g), quercetin-3-O-α-arabinofuranoside (12.0 mg/g), and quercetin (2.1 mg/g). It was also possible to isolate minor constituents׳ chlorogenic acid, neochlorogenic acid and procyanidin C1. The oral administration of AERi (100 mg/kg) significantly inhibited the neurogenic (37 ± 5%) and inflammatory (34 ± 7%) phases of formalin-induced pain. Acute and repeated treatment of animals with AERi (100 mg/kg, p.o.) once a day markedly reduced the mechanical hypersensitivity response induced by CFA, and this effect was evident until the day 10. Moreover, repeated treatment with AERi (100 mg/kg, p.o.) significantly reduced the levels of IL-1ß and TNF-α in the paw (22 ± 7% and 50 ± 19%) and in the spinal cord (100% and 100%) when compared to the CFA group. The AERi (100 mg/kg, p.o.) markedly reduced biting behavior induced by intrathecal injection of TNF-α (81 ± 11%). Finally, the effect of AERi was not associated with changes in locomotor activity or the corporal temperature of animals. CONCLUSION: These data show that aqueous extract of Rourea induta has significant antinociceptive action, which seems to be associated with an inhibition of pro-inflammatory cytokines activated pathways. These findings support the ethnomedical uses of this plant.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Connaraceae
Dor/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Polifenóis/uso terapêutico
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Connaraceae/química
Feminino
Formaldeído
Adjuvante de Freund
Interleucina-1beta
Masculino
Camundongos
Atividade Motora/efeitos dos fármacos
Dor/induzido quimicamente
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Polifenóis/isolamento & purificação
Polifenóis/farmacologia
Fator de Necrose Tumoral alfa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Interleukin-1beta); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tumor Necrosis Factor-alpha); 1HG84L3525 (Formaldehyde); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140512
[Lr] Data última revisão:
140512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140401
[St] Status:MEDLINE


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[PMID]:24345504
[Au] Autor:Dada OK; Akindele AJ; Morakinyo OA; Sofidiya MO; Ota D
[Ad] Endereço:Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.
[Ti] Título:Hypoglycemic and antioxidant activities of the hydroethanolic leaf extract of Byrsocarpus coccineus Schumach. & Thonn. (Connaraceae).
[So] Source:Chin J Nat Med;11(6):628-37, 2013 Nov.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats. METHODS: The effect of B. coccineus extract (100-800 mg · kg(-1), p.o.) on blood glucose levels in normal and glucose loaded rats, and alloxan-induced diabetic rats was determined. After 10 days of treatment, blood samples were collected from rats for lipid and insulin profiling. Animals were thereafter sacrificed and the kidneys, heart, and liver were harvested for antioxidant indices assay. RESULTS: In normal rats, B. coccineus did not cause significant reduction in blood glucose. At the dose of 800 mg · kg(-1), significant increase in blood glucose level was not observed 30 min. after glucose load. B. coccineus administered acutely did not generally produce significant reduction in blood glucose level in diabetic rats. Administered subacutely, the extract significantly reduced blood glucose level in diabetic rats from the 3(rd) day with peak effect observed at the dose of 800 mg · kg(-1) on the 10(th) day. The extract generally preserved in vivo antioxidant levels in the kidneys, heart, and liver, increased the level of high density lipoprotein and insulin, and reduced the level of triglycerides and low density lipoprotein compared to diabetic control. CONCLUSION: The findings in this study suggest that the hydroethanolic leaf extract Byrsocarpus coccineus possesses antidiabetic activity possibly mediated through inhibition of intestinal glucose absorption, in vivo antioxidant activity, and enhancement of regeneration of beta cells of the pancreas and insulin secretion.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Connaraceae/química
Diabetes Mellitus Tipo 2/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antioxidantes/efeitos adversos
Antioxidantes/química
Glicemia/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Feminino
Seres Humanos
Hipoglicemiantes/efeitos adversos
Hipoglicemiantes/química
Insulina/metabolismo
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/efeitos adversos
Extratos Vegetais/química
Folhas de Planta/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:141224
[Lr] Data última revisão:
141224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131219
[St] Status:MEDLINE


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[PMID]:24026541
[Au] Autor:Adisa RA; Olorunsogo OO
[Ad] Endereço:Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria.
[Ti] Título:Robustaside B and para­hydroxyphenol: phenolic and antioxidant compounds purified from Cnestis ferruginea D.C induced membrane permeability transition in rat liver mitochondria.
[So] Source:Mol Med Rep;8(5):1493-8, 2013 Nov.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The antioxidant properties of robustaside B and para­hydroxyphenol isolated from Cnestis ferruginea were measured as the rate of inhibition of thiobarbituric acid reactive substance (TBARS) production in the Fe2+/ascorbate system. The modulatory effects of the compounds on mitochondrial membrane permeability transition (MMPT) were monitored spectrophotometrically as decreases in light scattering at 540 nm. The varying concentrations of robustaside B and para­hydroxyphenol (0.05, 0.1, 0.2, 0.25, 0.5, 0.75 and 1 mM) significantly reduced (P<0.05) the amount of TBARS generated by the Fe2+/ascorbate system by 85.3, 86.4, 86.0, 86.1, 86.0, 86.0 and 86.0% and 86.7, 81.3, 81.3, 80, 80, 82.6 and 83.1%, respectively. Similarly, quercetin, a standard antioxidant, was found to induce an 80% reduction in the amount of TBARS produced. The same IC50 value of 0.025 mM was observed for robustaside B, para­hydroxyphenol and quercetin. Pre­incubation of varying concentrations of robustaside B (0.125, 0.2, 0.5 and 1 mM) with succinate­energized mitochondria induced MMPT pore opening by 0, ­33.3, ­59.3 and ­218.5%, compared with control mitochondria. Para­hydroxyphenol at 0.1, 0.2, 0.25 and 0.5 mM induced MMPT pore opening in a concentration­dependent manner up to 0.25 mM by ­21, ­54.4 and ­107.0%, respectively. Quercetin at 0.05, 0.1, 0.25, 0.5, 0.75 and 1 mM also induced MMPT pore opening in the absence of calcium in a concentration­dependent manner by 5, 3.7, ­42.6, ­81.5, ­187 and ­161.1%, respectively. The current observations confirm the antioxidant properties of robustaside B and para­hydroxyphenol, and indicate a potential therapeutic use of the compounds for the treatment of diseases requiring the induction of cell death, including cancer.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Permeabilidade da Membrana Celular/efeitos dos fármacos
Connaraceae/química
Glicosídeos/farmacologia
Hidroquinonas/farmacologia
Mitocôndrias Hepáticas/efeitos dos fármacos
Proteínas de Transporte da Membrana Mitocondrial/efeitos dos fármacos
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Cloreto de Cálcio/farmacologia
Masculino
Mitocôndrias Hepáticas/metabolismo
Quercetina/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glycosides); 0 (Hydroquinones); 0 (Mitochondrial Membrane Transport Proteins); 0 (Phenols); 0 (mitochondrial permeability transition pore); 0 (robustaside B); 9IKM0I5T1E (Quercetin); M4I0D6VV5M (Calcium Chloride); XV74C1N1AE (hydroquinone)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130913
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2013.1674


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[PMID]:23627469
[Au] Autor:Ishola IO; Tota S; Adeyemi OO; Agbaje EO; Narender T; Shukla R
[Ad] Endereço:Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria.
[Ti] Título:Protective effect of Cnestis ferruginea and its active constituent on scopolamine-induced memory impairment in mice: a behavioral and biochemical study.
[So] Source:Pharm Biol;51(7):825-35, 2013 Jul.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cnestis ferruginea Vahl ex DC (Connaraceae) (CF) is used in traditional African medicine in the management of CNS disorders. The degeneration and dysfunction of cholinergic neurons is closely associated with the cognitive deficits of Alzheimer's disease (AD) and oxidative stress has been implicated in its pathogenesis. However, the influence of C. ferruginea on the cholinergic system and oxidative stress parameters has not been explored. OBJECTIVE: The present study investigates the effect of methanol root extract of C. ferruginea and its active constituent amentoflavone (CF-2) on memory, oxidative stress and acetylcholinesterase (AChE) activity in scopolamine-induced amnesia. MATERIALS AND METHODS: Mice were orally treated with CF (25-200 mg/kg), CF-2 (6.25-25 mg/kg) for three days and memory impairment was induced by intraperitoneal injection of scopolamine (3 mg/kg). Memory function was evaluated by passive avoidance and Morris water maze tests. Biochemical parameters of oxidative stress and cholinergic function were estimated in brain after the completion of behavioral studies. RESULTS: Scopolamine caused memory impairment along with increased AChE activity and oxidative stress in mice brain. Oral administration of CF and CF-2 significantly prevented scopolamine-induced memory impairment, inhibited AChE and enhanced antioxidant enzyme activity in the brain following scopolamine injection as compared to vehicle administration in scopolamine (i.p.)-treated mice that were comparable to the effect of tacrine. DISCUSSION AND CONCLUSION: The study demonstrated that C. ferruginea and its constituent have significant protective effect against scopolamine-induced memory deficits in mice that can be attributed to their antioxidant and antiAChE activity.
[Mh] Termos MeSH primário: Biflavonoides/farmacologia
Connaraceae/química
Transtornos da Memória/prevenção & controle
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Administração Oral
Animais
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Aprendizagem da Esquiva/efeitos dos fármacos
Biflavonoides/administração & dosagem
Biflavonoides/isolamento & purificação
Inibidores da Colinesterase/administração & dosagem
Inibidores da Colinesterase/isolamento & purificação
Inibidores da Colinesterase/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Medicina Tradicional Africana
Transtornos da Memória/fisiopatologia
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Hidrobrometo de Escopolamina/toxicidade
Tacrina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biflavonoids); 0 (Cholinesterase Inhibitors); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); 4VX7YNB537 (Tacrine); 9I1VC79L77 (amentoflavone); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130501
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.767360


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[PMID]:23376104
[Au] Autor:Ishola IO; Chaturvedi JP; Rai S; Rajasekar N; Adeyemi OO; Shukla R; Narender T
[Ad] Endereço:Pharmacology Division, Central Drug Research Institute, Lucknow-226 001, Uttar Pradesh, India.
[Ti] Título:Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells.
[So] Source:J Ethnopharmacol;146(2):440-8, 2013 Mar 27.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cnestisferruginea (CF) Vahl ex DC (Connaraceae) is a shrub widely used in traditional African medicine for the treatment of various psychiatric illness and inflammatory conditions. AIM OF THE STUDY: This study was carried out to investigate the effect of amentoflavone isolated from methanolic root extract of CF on lipopolysaccharide (LPS)-induced neuroinflammatory cascade of events associated to the oxidative and nitrative stress, and TNF-α production in rat astrocytoma cell line (C6) and human monocytic leukemia cell line (THP-1), respectively. MATERIALS AND METHODS: Rat astrocytoma cells (C6) were stimulated with LPS (10µg/ml) alone and in the presence of different concentrations of amentoflavone (0.1-3µg/ml) for 24h incubation period. Nitrite release, reactive oxygen species (ROS), malondialdehyde (MDA) and reduced-glutathione (GSH) in C6 cells were estimated; while the TNF-α level was estimated in THP-1 cell lysate. In vivo analgesic activity was evaluated using mouse writhing and hot plate tests while the anti-inflammatory effect was investigated using carrageenan-induced oedema test. RESULTS: LPS (10µg/ml) significantly (P<0.05) stimulated C6 cells to release nitrite, ROS, MDA, and TNF-α generation while GSH was down regulated in comparison to control. However, amentoflavone significantly (P<0.05) attenuated nitrite, ROS, MDA and TNF-α generation and also up regulated the level of GSH. Amentoflavone per se did not have any significant effect on C6 and THP-1 cells. Amentoflavone (6.25-50mg/kg) significantly (P<0.05) reduced number of writhes and also increase pain threshold in hot plate test. It produced time course significant (P<0.05) decrease in oedema formation in rodents. DISCUSSION AND CONCLUSION: Findings in this study demonstrate the anti-neuroinflammatory and antinoceptive effects of amentoflavone which may suggest its beneficial roles in neuroinflammation associated disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Biflavonoides/farmacologia
Connaraceae
[Mh] Termos MeSH secundário: Ácido Acético
Animais
Anti-Inflamatórios/uso terapêutico
Astrocitoma
Biflavonoides/uso terapêutico
Carragenina
Linhagem Celular
Linhagem Celular Tumoral
Sobrevivência Celular
Edema/induzido quimicamente
Edema/tratamento farmacológico
Feminino
Glutationa/metabolismo
Temperatura Alta
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos
Masculino
Malondialdeído/metabolismo
Camundongos
Nitritos/metabolismo
Dor/tratamento farmacológico
Dor/etiologia
Fitoterapia
Raízes de Plantas
Ratos
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biflavonoids); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Nitrites); 0 (Reactive Oxygen Species); 0 (Tumor Necrosis Factor-alpha); 4Y8F71G49Q (Malondialdehyde); 9000-07-1 (Carrageenan); 9I1VC79L77 (amentoflavone); GAN16C9B8O (Glutathione); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130205
[St] Status:MEDLINE



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