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Pesquisa : B01.650.940.800.575.912.250.859.937.280 [Categoria DeCS]
Referências encontradas : 96 [refinar]
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[PMID]:29360848
[Au] Autor:Liu Z; Zhu J; Yang X; Wu H; Wei Q; Wei H; Zhang H
[Ad] Endereço:Research Center of Saline and Alkali Land of State Forestry Administration, Chinese Academy of Forestry, Beijing, P. R. China.
[Ti] Título:Growth performance, organ-level ionic relations and organic osmoregulation of Elaeagnus angustifolia in response to salt stress.
[So] Source:PLoS One;13(1):e0191552, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elaeagnus angustifolia is one of the most extensively afforested tree species in environment-harsh regions of northern China. Despite its exceptional tolerance to saline soil, the intrinsic adaptive physiology has not been revealed. In this study, we investigated the growth, organ-level ionic relations and organic osmoregulation of the seedlings hydroponically treated with 0, 100 and 200 mM NaCl for 30 days. We found that the growth characteristics and the whole-plant dry weight were not obviously stunted, but instead, were even slightly stimulated by the treatment of 100 mM NaCl. In contrast, these traits were significantly inhibited by 200 mM NaCl treatment. Interestingly, as compared with the control (0 mM NaCl), both 100 and 200 mM NaCl treatments had a promotional effect on root growth as evidenced by 26.3% and 2.4% increases in root dry weight, respectively. Roots had the highest Na+ and Cl- concentrations and obviously served as the sink for the net increased Na+ and Cl-, while, stems might maintain the capacity of effective Na+ constraint, resulting in reduced Na+ transport to the leaves. K+, Ca2+ and Mg2+ concentrations in three plant organs of NaCl-treated seedlings presented a substantial decline, eventually leading to an enormously drop of K+/Na+ ratio. As the salt concentration increased, proline and soluble protein contents continuously exhibited a prominent and a relatively tardy accumulation, respectively, whereas soluble sugar firstly fell to a significant level and then regained to a level that is close to that of the control. Taken together, our results provided quantitative measures that revealed some robust adaptive physiological mechanisms underpinning E. angustifolia's moderately high salt tolerance, and those mechanisms comprise scalable capacity for root Na+ and Cl- storage, effectively constrained transportation of Na+ from stems to leaves, root compensatory growth, as well as an immediate and prominent leaf proline accumulation.
[Mh] Termos MeSH primário: Elaeagnaceae/efeitos dos fármacos
Osmorregulação
Cloreto de Sódio/farmacologia
Estresse Fisiológico
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Cloretos/metabolismo
Elaeagnaceae/crescimento & desenvolvimento
Elaeagnaceae/fisiologia
Transporte de Íons
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Potássio/metabolismo
Plântulas/metabolismo
Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191552


  2 / 96 MEDLINE  
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[PMID]:28239062
[Au] Autor:Kan L; Wang L; Ding Q; Wu Y; Ouyang J
[Ad] Endereço:Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Key Laboratory of Forest Food Process and Safety, Beijing Forestry University.
[Ti] Título:Flash Extraction and Physicochemical Characterization of Oil from Elaeagnus mollis Diels Seeds.
[So] Source:J Oleo Sci;66(4):345-352, 2017 Apr 03.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A flash extraction method was used to isolate Elaeagnus mollis oil (EMO). The optimal extraction parameters, sample/solvent ratio and extraction temperature, were determined to be 1:10 (g/mL) and 40°C, respectively. Especially, the extraction yield reached 49.30% when the extraction time was as short as 2 min. No obvious difference was observed in fatty acid composition, iodine value, saponification number, total phenolic content and tocopherol content between flash-extracted EMO and Soxhlet-extracted EMO, but their physicochemical values were lower than those of cold-pressed EMO. Cold-pressed EMO had higher oxidation stability, DPPH (1-diphenyl-2-picrylhydrazyl) and hydroxyl radical-scavenging activities than flash-extracted EMO and Soxlet extracted EMO. The flash extraction is demonstrated to be an alternative, efficient method for the vegetable oil production.
[Mh] Termos MeSH primário: Elaeagnaceae/química
Óleos Vegetais/química
Sementes/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Ácidos Graxos/análise
Radical Hidroxila/química
Extração Líquido-Líquido
Oxirredução
Picratos/química
Óleos Vegetais/isolamento & purificação
Tocoferóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Fatty Acids); 0 (Picrates); 0 (Plant Oils); 3352-57-6 (Hydroxyl Radical); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16200


  3 / 96 MEDLINE  
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[PMID]:28033719
[Au] Autor:Shang YY; Qin Q; Li MS; Xu HY; Ge YB
[Ad] Endereço:a School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , China.
[Ti] Título:Flavonol glycosides from the leaves of Elaeagnus pungens.
[So] Source:Nat Prod Res;31(9):1066-1072, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The leaves of Elaeagnus pungens were extracted and successively purified by a set chromatographic techniques. The structures of the obtained constituents were elucidated on the basis of spectroscopic methods including 1D/2D NMR and high resolution-MS. One new flavonoid glycosides, kaempferol 3-O-ß-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 6)-[α-l-rhamnopyranosyl(1 → 2)]-ß-d-galactopyranoside-7-O-ß-d-glucopyranoside (1), along with five known compounds (2-6) were isolated and identified. The MTT assay in vitro showed that the isolated flavonol glycosides have no proliferating activity, suggesting no aggravating impact on the increased airway smooth muscle cells.
[Mh] Termos MeSH primário: Elaeagnaceae/química
Flavonóis/isolamento & purificação
Glicosídeos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Flavonóis/química
Flavonóis/farmacologia
Glicosídeos/química
Glicosídeos/farmacologia
Masculino
Folhas de Planta/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonols); 0 (Glycosides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1272109


  4 / 96 MEDLINE  
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[PMID]:27706676
[Au] Autor:Xie YH; Li XP; Xu ZX; Qian P; Li XL; Wang YQ
[Ad] Endereço:Staff Room of Diagnosis, Basic Medicine College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
[Ti] Título:Effect of compound Maqin decoction on TGF-ß1/Smad proteins and IL-10 and IL-17 content in lung tissue of asthmatic rats.
[So] Source:Genet Mol Res;15(3), 2016 Sep 02.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:In this research, compound Maqin decoction (CMD) has been shown to positively affect in airway inflammation of asthma models. We evaluated the effects of CMD on the expression of transforming growth factor (TGF)-ß1/Smad proteins, interleukin (IL)-17, and IL-10 in lung tissue of asthmatic rats. Asthma was induced in a rat model using ovalbumin. After a 4-week treatment with CMD, rats were killed to evaluate the expression of TGF-ß1 and Smad proteins in lung tissue. IL-10 and IL-17 levels in lung tissue homogenates were determined by ELISA. The expression of TGF-ß1 and Smad3 protein increased, whereas expression of Smad7 protein decreased upon high-dose or low-dose treatment with CMD or by intervention with dexamethasone, compared to the control. There was a significant difference between treatment with a high dose CMD and the control treatment, but no significant difference was found between high-dose CMD treatment and dexamethasone intervention. The expression of TGF-ß1 and Smad7 protein increased, whereas the expression of Smad3 protein decreased in the model group compared to other groups. In the CMD high-dose group, low-dose group, and dexamethasone intervention group, the IL-17 concentrations in lung tissue homogenates were decreased, while IL-10 levels were increased. Again, there was a significant difference between CMD high-dose and control treatment, but not between CMD high-dose treatment and dexamethasone intervention. Thus, positive effects of CMD against asthmatic airway remodeling may be due to its regulatory effect on TGF-ß1, Smad3, and Smad7 protein levels and on cytokines such as IL-10 and IL-17.
[Mh] Termos MeSH primário: Antiasmáticos/farmacologia
Asma/tratamento farmacológico
Pulmão/efeitos dos fármacos
Extratos Vegetais/farmacologia
Fator de Crescimento Transformador beta1/imunologia
[Mh] Termos MeSH secundário: Remodelação das Vias Aéreas/efeitos dos fármacos
Animais
Antiasmáticos/isolamento & purificação
Asma/induzido quimicamente
Asma/imunologia
Asma/patologia
Berberidaceae/química
Dexametasona/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Elaeagnaceae/química
Ephedra/química
Regulação da Expressão Gênica
Interleucina-10/genética
Interleucina-10/imunologia
Interleucina-17/genética
Interleucina-17/imunologia
Pulmão/imunologia
Pulmão/patologia
Masculino
Ovalbumina
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Scutellaria baicalensis/química
Transdução de Sinais
Proteína Smad3/genética
Proteína Smad3/imunologia
Proteína Smad7/genética
Proteína Smad7/imunologia
Fator de Crescimento Transformador beta1/genética
Xanthium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Interleukin-17); 0 (Madh3 protein, rat); 0 (Plant Extracts); 0 (Smad3 Protein); 0 (Smad7 Protein); 0 (Smad7 protein, rat); 0 (Transforming Growth Factor beta1); 130068-27-8 (Interleukin-10); 7S5I7G3JQL (Dexamethasone); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15037539


  5 / 96 MEDLINE  
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[PMID]:27593387
[Au] Autor:Niknam F; Azadi A; Barzegar A; Faridi P; Tanideh N; Zarshenas MM
[Ti] Título:Phytochemistry and Phytotherapeutic Aspects of Elaeagnus angustifolia L.
[So] Source:Curr Drug Discov Technol;13(4):199-210, 2016.
[Is] ISSN:1875-6220
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:Persian or Russian olive (Elaeagnus angustifolia L.), from the family Elaeagnaceae, is a nitrogen-fixing thorny shrub extensively used in traditional medicine to alleviate pain and treat rheumatoid arthritis, osteoarthritis, gastrointestinal problems, fever, and asthma. The current review has tried to give a concise overview of the phytochemistry and pharmacological properties of the plant from published data. Accordingly, published English literatures on Elaeagnus angustifolia were gathered from popular databases such as PubMed, Scopus, Web of Science, and ScienceDirect up to 31 December 2015. In accordance with traditional and ethnopharmacological uses, different extracts of E. angustifolia have been known for their antioxidant, anti-inflammatory, anti-nociceptive, antimicrobial, muscle relaxant, anti-ulcer and wound-healing capabilities. Additionally, cardioprotective, antitumor and anti-mutagenic effects of the herb have been demonstrated by current assessments. Despite numerous experimental studies, there is a notable lack of profound and comprehensive clinical trials as well as critical research on E. angustifolia toxicity and teratogenicity. With reference to various pharmacological effects based on experimental and animal investigation, it is worthy to mention a frame for respective clinical studies in further studies.
[Mh] Termos MeSH primário: Elaeagnaceae
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Preparações de Plantas/análise
Preparações de Plantas/farmacologia
Preparações de Plantas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Preparations)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE


  6 / 96 MEDLINE  
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[PMID]:27422354
[Au] Autor:Singh A; Singh NB; Hussain I; Singh H; Yadav V; Singh SC
[Ad] Endereço:Plant Physiology Laboratory, Department of Botany, University of Allahabad, Allahabad 211002, U.P., India.
[Ti] Título:Green synthesis of nano zinc oxide and evaluation of its impact on germination and metabolic activity of Solanum lycopersicum.
[So] Source:J Biotechnol;233:84-94, 2016 Sep 10.
[Is] ISSN:1873-4863
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the present study, zinc oxide nanoparticles (ZnO NPs) were rapidly synthesized at room temperature by treating zinc acetate dihydrate with the flower extract of Elaeagnus angustifolia (Russian olive). The formation of ZnO NPs was primarily confirmed by UV-visible absorption spectrum in the range of 250-700nm. XRD analysis and DLS particle size analyzer revealed the size of ZnO NPs. The FTIR spectrum revealed the presence of phytochemicals in the flower extract mediated ZnO NPs. Moreover, the morphology of the ZnO NPs was determined using SEM. Seeds of Solanum lycopersicum (tomato) were separately treated with different concentrations of synthesized ZnO NPs and zinc sulphate (ZnSO4) salt suspensions (common zinc supplement). The effect of these treatments on seed germination, seedling vigor, chlorophyll, protein and sugar contents as well as on the activities of lipid peroxidation and antioxidant enzyme were studied. Leaves of plants treated with 6.1mM concentration of ZnO NPs recorded maximum reflectance while it was minimum in plants treated with 1.2mM concentration of NPs. The effect of synthesized ZnO NPs on seedling vigor, pigment, protein and sugar content was found affirmative at lower concentrations contrary to control and ZnSO4 salt. The inhibitory effect at higher concentration of NPs indicated importance in the precise application of NPs, in Zn deficient system, where plant response varies with concentration. To the best of our knowledge this is the first report on Elaeagnus angustifolia mediated synthesis of ZnO NPs and their effects on germination and physiological activity of tomato.
[Mh] Termos MeSH primário: Germinação/efeitos dos fármacos
Lycopersicon esculentum/efeitos dos fármacos
Nanopartículas Metálicas/química
Extratos Vegetais/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Elaeagnaceae/química
Flores/química
Química Verde
Lycopersicon esculentum/metabolismo
Nanopartículas Metálicas/toxicidade
Folhas de Planta/química
Sementes/efeitos dos fármacos
Óxido de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE


  7 / 96 MEDLINE  
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[PMID]:27209774
[Au] Autor:Ozen SA; Yaman M
[Ti] Título:Examination of Correlation between Histidine and Cadmium Absorption by Eleagnus angustifolia L., Vitis vinifera L. and Nerium oleander L. Using HPLC-MS and ICP-MS.
[So] Source:Guang Pu Xue Yu Guang Pu Fen Xi;36(2):588-92, 2016 Feb.
[Is] ISSN:1000-0593
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:In this study, HPLC-MS and ICP-MS methods wereused for the determination of histidine and cadmium in Eleagnus angustifolia L., Vitis vinifera L. and Nerium oleander L. leaves taken from industrial area including Gaziantep and Bursa cities. To histidine determination by HPLC-MS, flow rate of mobile phase, fragmentor potential, injection volume and column temperature were optimized as 0.2 mL · min⁻¹, 70 V, 15 µL and 20 °C, respectively. For extraction of histidine from plants, distilled water was used by applying on 90 °C and 30 min. The concentrations (as mg · kg⁻¹) of histidine were found to be in range of 8~22 for Eleagnus angustifolia L., 10~33 for Vitis vinifera L. and 6~11 for Nerium oleander L. The concentrations of cadmium were found to be in ranges of 6~21 µg · kg⁻¹ for Vitis vinifera L. 15~110 µg · kg⁻¹ for Eleagnus angustifolia L. and 63~218 µg · kg⁻¹ for Nerium oleander L.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Elaeagnaceae/metabolismo
Histidina/metabolismo
Nerium/metabolismo
Vitis/metabolismo
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Folhas de Planta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
00BH33GNGH (Cadmium); 4QD397987E (Histidine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160523
[Lr] Data última revisão:
160523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


  8 / 96 MEDLINE  
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[PMID]:26930244
[Au] Autor:Nikniaz Z; Mahdavi R; Nikniaz L; Ebrahimi A; Ostadrahimi A
[Ad] Endereço:a Liver and Gastrointestinal Diseases Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
[Ti] Título:Effects of Elaeagnus angustifolia L. on Lipid Profile and Atherogenic Indices in Obese Females: A Randomized Controlled Clinical Trial.
[So] Source:J Diet Suppl;13(6):595-606, 2016 Nov.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present randomized double-blinded placebo-controlled study, the effect of Elaeagnus angustifolia L. (EA) whole fruit and medulla powders on anthropometric indices, serum lipid profile, and atherogenic indices in females with knee osteoarthritis (OA) was investigated. Ninety females with mild to moderate knee osteoarthritis were randomly assigned to one of three groups-medulla powder, whole fruit powder, or placebo. The subjects received 15 g/day of medulla powder of EA, whole fruit powder of EA, or placebo. Lipid profile, weight, and dietary intake were measured at baseline and at the end of the study. Body mass index and atherogenic indices were calculated. Statistical analysis was performed using SPSS version 13.0, and Paired t tests, analysis of variance (ANOVA), analysis of covariance (ANCOVA), and the Tukey post hoc test were used to compare within-group and between-group values. After 8 weeks of supplementations, compared with the baseline, significant reductions in total cholesterol (TC), low density lipoprotein/high density lipoprotein (LDL/HDL), and TC/HDL ratios were observed in the two supplemented groups; however, the reduction of these values was not statistically significant in the placebo group. There were significant differences between the patients who received medulla powder and placebo group in the case of changes in TC/HDL and LDL/HDL ratios (p < .001). However, no significant differences were found between the two supplemented groups in the case of changes in studied values (p > .05). Generally, whole fruit and medulla powders of Elaeagnus angustifolia L. had positive effects, especially in decreasing total cholesterol and atherogenic indices in females with knee OA.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Elaeagnaceae/química
Lipídeos/sangue
Obesidade/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Analgésicos
Antropometria
Aterosclerose/sangue
Índice de Massa Corporal
Colesterol/sangue
Método Duplo-Cego
Feminino
Frutas/química
Seres Humanos
Irã (Geográfico)
Articulação do Joelho
Meia-Idade
Obesidade/sangue
Obesidade/fisiopatologia
Osteoartrite/tratamento farmacológico
Osteoartrite/fisiopatologia
Fitoterapia
Placebos
Extratos Vegetais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Lipids); 0 (Placebos); 0 (Plant Extracts); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.3109/19390211.2016.1150933


  9 / 96 MEDLINE  
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[PMID]:26584455
[Au] Autor:Hui W; Yongliang Y; Yongde C; Guo L; Li L; Zhonglin Y; Hui J; Qinghua H
[Ad] Endereço:School of Pharmacy, China Pharmaceutical University, Nanjing, P. R. China.
[Ti] Título:Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3.
[So] Source:Planta Med;82(4):289-97, 2016 Mar.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Emodinol, 1ß,3ß,23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our research group, has been demonstrated to exhibit uricosuric activity by our previous study. The aim of this study was to evaluate the uricosuric and nephroprotective effects of emodinol and explore its possible mechanisms in potassium oxonate-induced hyperuricemic mice with renal dysfunction. Mice were orally administrated 250 mg/kg of potassium oxonate once daily for 7 consecutive days to induce hyperuricemia with renal dysfunction. Emodinol was given at doses of 25, 50, and 100 mg/kg on the same day 1 h after oxonate treatment, and allopurinol (10 mg/kg) was given as a positive control. After 1 week, serum uric acid, serum creatinine, urine uric acid, urine creatinine, blood urea nitrogen, and hepatic xanthine oxidase activity were determined. The mRNA and protein levels of urate transporter 1, glucose transporter 9, ATP-binding cassette subfamily G member 2, organic anion transporter 1, oncoprotein-induced transcript 3, and organic cation/carnitine transporters in the kidney were detected by real-time polymerase chain reaction and Western blot analysis. In addition, urinary and renal Tamm-Horsfall glycoprotein concentrations were examined by ELISA assays. Emodinol significantly reduced serum urate levels, increased urinary urate levels and fractional excretion of uric acid, and inhibited hepatic xanthine oxidase activity in hyperuricemic mice. Moreover, potassium oxonate administration led to dys expressions of renal urate transporter 1, glucose transporter 9, ATP-binding cassette subfamily G member 2, organic anion transporter 1, and oncoprotein-induced transcript 3 as well as alternations of uromodulin concentrations, which could be reversed by emodinol. On the other hand, treatment of emodinol caused upregulated expressions of organic cation/carnitine transporters, resulting in an improvement of renal function characterized by decreased serum creatinine and blood urea nitrogen levels. Emodinol exhibited hypouricemic and nephroprotective actions by inhibiting xanthine oxidase activity and regulating renal ion transporters and oncoprotein-induced transcript 3, which may be a potential therapeutic agent in hyperuricemia and renal dysfunction.
[Mh] Termos MeSH primário: Elaeagnaceae/química
Hiperuricemia/tratamento farmacológico
Rim/efeitos dos fármacos
Proteínas de Membrana/metabolismo
Ácido Oleanólico/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Hiperuricemia/induzido quimicamente
Hiperuricemia/patologia
Transporte de Íons
Rim/patologia
Masculino
Camundongos
Estrutura Molecular
Ácido Oleanólico/química
Ácido Oleanólico/uso terapêutico
Ácido Oxônico
Substâncias Protetoras/uso terapêutico
Proteinúria/tratamento farmacológico
Ácido Úrico/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid); 0 (LZP protein, mouse); 0 (Membrane Proteins); 0 (Protective Agents); 268B43MJ25 (Uric Acid); 4R7FFA00RX (potassium oxonate); 5VT6420TIG (Oxonic Acid); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151120
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1558212


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[PMID]:26224722
[Au] Autor:Zeinalzadeh S; Akbarzadeh M; Mohagheghzadeh A; Faridi P; Sayadi M
[Ad] Endereço:Department of midwifery, Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Comparison of the Effects of Elaeagnus angustifolia Flower Capsule and Sildenafil Citrate Tablet on Anxiety Resulting From Sexual Dysfunction in Women Referring to the Selected Clinics of Shiraz University of Medical Sciences.
[So] Source:J Evid Based Complementary Altern Med;21(3):186-93, 2016 Jul.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dissatisfaction from sexual relationships can result in deprivation as well as problems, such as depression, anxiety, and destruction of family's mental health. One hundred twenty-five women (18 to 40 years) who suffered from hypoactive sexual desire disorder were divided into Elaeagnus angustifolia flower (4.5 g g daily for 35 days), sildenafil citrate tablet (50 mg for 4 weeks), and control groups. The study data were collected using the Female Sexual Function Index and Spielberger's questionnaire and measurement of thyroid-stimulating hormone and prolactin hormone. In the Elaeagnus angustifolia group, the mean score of state and trait anxiety decreased after the intervention. In the sildenafil citrate group also, the mean score of state anxiety decreased from 22.15 ± 4.98 to 20.1 ± 5.15 (P = .001) and that of trait anxiety decreased from 23.07 ± 4.44 to 21.55 ± 4.82 (P = .002) after the intervention. Consumption of sildenafil citrate tablet was effective in reduction of the mean score of anxiety resulting from sexual dysfunction.
[Mh] Termos MeSH primário: Elaeagnaceae/química
Extratos Vegetais/administração & dosagem
Disfunções Sexuais Fisiológicas/tratamento farmacológico
Citrato de Sildenafila/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Flores/química
Seres Humanos
Satisfação do Paciente
Disfunções Sexuais Fisiológicas/psicologia
Comprimidos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Tablets); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE
[do] DOI:10.1177/2156587215595777



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