Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.280.500 [Categoria DeCS]
Referências encontradas : 379 [refinar]
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[PMID]:29262676
[Au] Autor:Suvanto J; Tähtinen P; Valkamaa S; Engström MT; Karonen M; Salminen JP
[Ad] Endereço:Natural Chemistry Research Group, Department of Chemistry, University of Turku , FI-20014, Turku, Finland.
[Ti] Título:Variability in Foliar Ellagitannins of Hippophaë rhamnoides L. and Identification of a New Ellagitannin, Hippophaenin C.
[So] Source:J Agric Food Chem;66(3):613-620, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Berries of common sea-buckthorn (Hippophaë rhamnoides L.) are well-known and used for their bioactive components, and while there is a considerable amount of research on the leaves as well, their ellagitannins (ETs) have not been a prominent focus of research. We identified and quantified ten major hydrophilic polyphenols, all ETs, in H. rhamnoides leaves and compared their abundance between 58 plant individuals. Of these compounds, hippophaenin C was characterized as a new ellagitannin by various spectrometric methods. The total concentrations of ETs ranged from 42.5 mg g dry weight (DW) to 109.1 mg g DW between individual plants. Among the ETs, hippophaenin C, stachyurin, and casuarinin were on average the most abundant compounds. Sexes did not differ significantly, while cultivars showed variation in some ETs. These results suggest that H. rhamnoides leaves could be a potential and rich source of several ETs.
[Mh] Termos MeSH primário: Hippophae/química
Taninos Hidrolisáveis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Espectrometria de Massas
Estrutura Molecular
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (ellagitannin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04834


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[PMID]:29324845
[Au] Autor:Yang M; Yang D; Yu X
[Ad] Endereço:Department of Forestry, College of Forestry, Northwest A&F University, Yangling, China.
[Ti] Título:Soil microbial communities and enzyme activities in sea-buckthorn (Hippophae rhamnoides) plantation at different ages.
[So] Source:PLoS One;13(1):e0190959, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the impact of forest age and season on the soil microbial community and enzyme activities in sea-buckthorn plantation system and to determine the relative contributions to soil microbial properties. Soil sampling was carried out in the dry season (April) and wet season (September) in four areas, including: abandoned farmland (NH), an 8-year- old plantation (young plantation, 8Y), a 13-year-old plantation (middle-aged plantation, 13Y), and an 18-year-old plantation (mature plantation, 18Y). The results showed that forest age and season have a significant effect on soil microbial community structure and enzyme activities. The total, bacterial, fungal, Gram-negative (G+), and Gram-positive (G-) PLFAs increased gradually with forest age, with the highest values detected in 18Y. All the detected enzyme activities showed the trend as a consequence of forest age. The microbial PLFAs and soil enzyme activities were higher in the wet season than the dry season. However, there were no significant interactions between forest age and season. A Correlation analysis suggested that soil microbial communities and enzyme activities were significantly and positively correlated with pH, total nitrogen (TN) and available phosphorus (AP). Season had a stronger influence on soil microbial communities than forest age. In general, sea-buckthorn plantations establishment might be a potential tool for maintaining and increasing soil fertility in arid and semi-arid regions.
[Mh] Termos MeSH primário: Florestas
Hippophae/enzimologia
Microbiologia do Solo
[Mh] Termos MeSH secundário: China
Clima Desértico
Análise Discriminante
Ácidos Graxos/análise
Concentração de Íons de Hidrogênio
Nitrogênio/análise
Fósforo/análise
Estações do Ano
Solo/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Soil); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190959


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[PMID]:28466134
[Au] Autor:Czaplicki S; Ogrodowska D; Zadernowski R; Konopka I
[Ad] Endereço:Chair of Plant Food Chemistry and Processing, Faculty of Food Sciences, University of Warmia and Mazury, Plac Cieszynski 1, 10-726, Olsztyn, Poland. selek@go2.pl.
[Ti] Título:Effect of Sea-Buckthorn (Hippophaë rhamnoides L.) Pulp Oil Consumption on Fatty Acids and Vitamin A and E Accumulation in Adipose Tissue and Liver of Rats.
[So] Source:Plant Foods Hum Nutr;72(2):198-204, 2017 Jun.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An in vivo experiment was conducted to determine the effect of sea-buckthorn pulp oil feeding on the fatty acid composition of liver and adipose tissue of Wistar rats and the liver accumulation of retinol, its esters and α-tocopherol. For a period of 28 days, rats were given a modified casein diet (AIN-93) in which sea-buckthorn pulp oil, soybean oil and pork lard were used as sources of fat. Compared to the other fat sources, sea-buckthorn pulp oil was the most abundant in C16 fatty acids, carotenoids (mainly ß-carotene) and tocopherols (mainly α-tocopherol). Its consumption was reflected in an increased share of palmitoleic acid in adipose tissue and the liver and an increased level of retinol in liver tissues (this was not observed for its esters). Although the type of fat did not have a significant effect on the average content of α-tocopherol in the liver, the variation of saturation of this tissue with α-tocopherol was the lowest when rats were fed a diet containing sea-buckthorn oil. This experiment indicates the possibility of affecting adipose tissue and liver by a diet.
[Mh] Termos MeSH primário: Ácidos Graxos/metabolismo
Hippophae/química
Óleos Vegetais/metabolismo
Vitamina A/metabolismo
Vitamina E/metabolismo
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Carotenoides/metabolismo
Gorduras na Dieta/metabolismo
Ácidos Graxos Monoinsaturados/metabolismo
Fígado/metabolismo
Masculino
Óleos Vegetais/química
Ratos
Ratos Wistar
Óleo de Soja/metabolismo
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Plant Oils); 11103-57-4 (Vitamin A); 1406-18-4 (Vitamin E); 209B6YPZ4I (palmitoleic acid); 36-88-4 (Carotenoids); 8001-22-7 (Soybean Oil); SI6O3IW77Z (lard)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-017-0610-9


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[PMID]:28530596
[Au] Autor:Ursache FM; Ghinea IO; Turturica M; Aprodu I; Râpeanu G; Stanciuc N
[Ad] Endereço:Faculty of Food Science and Engineering, Dunarea de Jos University of Galati, Romania.
[Ti] Título:Phytochemicals content and antioxidant properties of sea buckthorn (Hippophae rhamnoides L.) as affected by heat treatment - Quantitative spectroscopic and kinetic approaches.
[So] Source:Food Chem;233:442-449, 2017 Oct 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of thermal processing (50-100°C) on the degradation of the phytochemicals in sea buckthorn extract was investigated using chromatographic, fluorescence and FT-IR spectroscopy techniques and degradation kinetics. Heating the sea buckthorn extract resulted in structural changes that led to red- or blue-shifts in maximum emission, depending on temperature and excitation wavelengths. The attenuated total reflectance analysis of the sea buckthorn extract revealed a satisfactory thermostability of compounds at high temperatures. A fractional conversion kinetic model was used to describe the mechanism of degradation in terms of rate and activation energy. Activation energies for total carotenoids, polyphenolic, flavonoids, and antioxidant activity were 8.45±0.93kJ/mol, 2.50±0.66kJ/mol, 22.50±7.26kJ/mol and 15.22±2.75kJ/mol, respectively. The kinetic parameters evidence a higher thermal stability of carotenoids and polyphenols, suggesting higher degradation rates for flavonoids and antioxidant activity. Our results demonstrate that industrial process optimization in terms of time-temperature combinations demands product specific kinetic data.
[Mh] Termos MeSH primário: Antioxidantes/química
Hippophae/química
Temperatura Alta
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28530574
[Au] Autor:Ma X; Laaksonen O; Heinonen J; Sainio T; Kallio H; Yang B
[Ad] Endereço:Food Chemistry and Food Development, Department of Biochemistry, University of Turku, FI-20014 Turku, Finland. Electronic address: xueying.ma@utu.fi.
[Ti] Título:Sensory profile of ethyl ß-d-glucopyranoside and its contribution to quality of sea buckthorn (Hippophaë rhamnoides L.).
[So] Source:Food Chem;233:263-272, 2017 Oct 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The contribution of ethyl ß-d-glucopyranoside (EG) to sensory profile of sea buckthorn (Hippophaë rhamnoides ssp. rhamnoides) was studied. The content of natural existing EG varied between 0.6 and 19.8g/L in the sea buckthorn studied. The taste threshold of pure EG was estimated in water solution as 1.1±1.3g/L, and the suprathreshold aqueous EG solution (5.0g/L) was perceived mainly as bitter. In aqueous sugar-acid mixtures, acids were the major contributors to sourness and astringency, whereas the added EG or sugars showed little impact on the overall sensory profile. EG addition increased the bitterness of sea buckthorn juice. The sensory profiles of the juices were dominated by intense sourness correlating with the malic acid content. The bitterness of the juices correlated with the EG content as well as the ratios EG/acids and EG/sugars. EG content shall be considered when selecting raw materials for industrial processing.
[Mh] Termos MeSH primário: Hippophae
[Mh] Termos MeSH secundário: Carboidratos
Frutas
Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28489850
[Au] Autor:Qiong; Zhang W; Wang H; Zeng L; Birks HJB; Zhong Y
[Ad] Endereço:Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai, China.
[Ti] Título:Testing the effect of the Himalayan mountains as a physical barrier to gene flow in Hippophae tibetana Schlect. (Elaeagnaceae).
[So] Source:PLoS One;12(5):e0172948, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hippophae tibetana is a small, dioecious wind-pollinated shrub endemic to the Tibetan-Qinghai Plateau. It is one of the shrubs that occur at very high elevations (5250 m a.s.l.). The Himalayan mountains provides a significant geographical barrier to the Qinghai-Tibetan Plateau, dividing the Himalayan area into two regions with Nepal to the south and Tibet to the north. There is no information on how the Himalayan mountains influence gene flow and population differentiation of alpine plants. In this study, we analyzed eight nuclear microsatellite markers and cpDNA trnT-trnF regions to test the role of the Himalayan mountains as a barrier to gene flow between populations of H. tibetana. We also examined the fine-scale genetic structure within a population of H. tibetana on the north slope of Mount (Mt.) Everest. For microsatellite analyses, a total of 241 individuals were sampled from seven populations in our study area (4 from Nepal, 3 from Tibet), including 121 individuals that were spatially mapped within a 100 m × 100 m plot. To test for seed flow, the cpDNA trnT-trnF regions of 100 individuals from 6 populations (4 from Nepal, 2 from Tibet) were also sequenced. Significant genetic differentiation was detected between the two regions by both microsatellite and cpDNA data analyses. These two datasets agree about southern and northern population differentiation, indicating that the Himalayan mountains represent a barrier to H. tibetana limiting gene flow between these two areas. At a fine scale, spatial autocorrelation analysis suggests significant genetic structure within a distance of less than 45 m, which may be attributed mainly to vegetative reproduction and habitat fragmentation, as well as limited gene flow.
[Mh] Termos MeSH primário: Fluxo Gênico
Hippophae/genética
[Mh] Termos MeSH secundário: Haplótipos
Repetições de Microssatélites/genética
Nepal
Filogenia
Tibet
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172948


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[PMID]:28379171
[Au] Autor:Kimura Y; Mori D; Imada T; Izuta Y; Shibuya M; Sakaguchi H; Oonishi E; Okada N; Matsumoto K; Tsubota K
[Ad] Endereço:Gifu Shellac Manufacturing Co., Ltd., Gifu 500-8618, Japan. qqwp4kyq.izt@gmail.com.
[Ti] Título:Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid.
[So] Source:Nutrients;9(4), 2017 Apr 05.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sea buckthorn ( -derived products have traditionally been used as food and medicinal ingredients in Eastern countries. The purpose of this study was to investigate the effect of oral intake of sea buckthorn oil products on tear secretion using a murine dry eye model. Orally administered sea buckthorn pulp oil (not seed oil) restored aqueous tear secretion to its normal value under a dry eye condition. Palmitoleate (C16:1), a fatty acid present in sea buckthorn pulp oil, preserved tear secretion and suppressed inflammatory cytokines in the lacrimal gland to the same extent as that by pulp oil. These results suggest that an oral intake of sea buckthorn pulp oil has a potency to preserve tear secretion capacity in the dry eye state and palmitoleate, its main constituent fatty acid, is an active component of the oil. This effect may enable a potent diet-based treatment for the prevention of dry eye.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/tratamento farmacológico
Ácidos Graxos Monoinsaturados/administração & dosagem
Hippophae/química
Óleos Vegetais/administração & dosagem
Lágrimas/secreção
[Mh] Termos MeSH secundário: Administração Oral
Animais
Gorduras na Dieta/administração & dosagem
Modelos Animais de Doenças
Ácidos Graxos/administração & dosagem
Ácidos Graxos/sangue
Feminino
Camundongos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Plant Oils); 209B6YPZ4I (palmitoleic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28283451
[Au] Autor:Kim J; Lee CM
[Ad] Endereço:Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
[Ti] Título:Wound healing potential of a polyvinyl alcohol-blended pectin hydrogel containing Hippophae rahmnoides L. extract in a rat model.
[So] Source:Int J Biol Macromol;99:586-593, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, we investigated the effect of a polyvinyl alcohol-blended pectin hydrogel (PVA-PT HG) containing the extracts of Hippophae rhamnoides L. (H. rhamnoides L.) leaves on wound healing in a rat model. The total phenolic content in the extract solution was 40.64±2.7 GAE mg/g and that of flavonoids was 13.15±1.8 QE mg/g. Of the total flavonoids in HGs, 61.6 and 50.0% were released at pH 5.5 and 7.4 after 60min. In rat acute wound models, the wound size was reduced significantly and the recovery rate was significantly higher after treatment with HG containing the extracts, compared with treatment with the control and HG only. The wound healing effects of the HG containing the extracts were confirmed by histological evaluation of the wound tissue. Therefore, HG containing extracts from H. rhamnoides L. leaves enhanced wound healing effectively, and so may be developed as a cover to promote wound healing.
[Mh] Termos MeSH primário: Hippophae/química
Hidrogéis/química
Pectinas/química
Pectinas/farmacologia
Álcool de Polivinil/química
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Flavonoides/química
Camundongos
Óxido Nítrico/metabolismo
Pectinas/toxicidade
Células RAW 264.7
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Hydrogels); 0 (Pectins); 31C4KY9ESH (Nitric Oxide); 9002-89-5 (Polyvinyl Alcohol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28256654
[Au] Autor:Jiang F; Guan H; Liu D; Wu X; Fan M; Han J
[Ad] Endereço:College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. hanjianchun@hotmail.com.
[Ti] Título:Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways.
[So] Source:Food Funct;8(3):1313-1322, 2017 Mar 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sea buckthorn has long been used as a functional food to regulate cholesterol, relieve angina, and diminish inflammation. Flavonoids are one of the main active components in sea buckthorn. We investigated the effects of sea buckthorn flavonoid (SF) treatment on two pathways that mediate inflammation, the mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, to explore the anti-inflammatory activity of SFs in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The LPS-induced over-production of nitric oxide (NO) and prostaglandin E2 (PGE ) was inhibited by SFs through a mechanism related to the modulatory effects of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) genes. Additionally, SFs downregulated the production and mRNA expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1ß. Moreover, SFs inhibited the phosphorylation of the p38 and stress-activated protein kinase/jun amino-terminal kinase (SAPK/JNK) MAPK pathways, and they reduced the nuclear translocation of NF-κB to prevent its activation by blocking the phosphorylation and degradation of inhibitor protein of NF-κB α (IκB-α). Based on these findings, SFs may exert their inhibitory effects on inflammation by regulating the release of inflammatory mediators through the MAPK and NF-κB pathways. SFs highlight the potential benefits of using functional foods with anti-inflammatory actions to combat inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Flavonoides/farmacologia
Hippophae/química
Inflamação/tratamento farmacológico
Macrófagos/efeitos dos fármacos
Proteínas Quinases Ativadas por Mitógeno/imunologia
NF-kappa B/imunologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Flavonoides/isolamento & purificação
Seres Humanos
Inflamação/genética
Inflamação/imunologia
Lipopolissacarídeos/efeitos adversos
Lipopolissacarídeos/imunologia
Macrófagos/imunologia
Camundongos
Proteínas Quinases Ativadas por Mitógeno/genética
NF-kappa B/genética
Extratos Vegetais/isolamento & purificação
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Flavonoids); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01873d


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[PMID]:28248545
[Au] Autor:Yang X; Wang Q; Pang ZR; Pan MR; Zhang W
[Ad] Endereço:a School of Life Sciences , East China Normal University , Shanghai , P.R. China.
[Ti] Título:Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.
[So] Source:Pharm Biol;55(1):1207-1214, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited. OBJECTIVE: We sought to determine if FSH can reduce body weight and regulate lipid metabolism disorder in high fat diet (HFD)-induced obese mouse model, and to investigate potential molecular targets involved. MATERIALS AND METHODS: C57BL/6 mice were fed with HFD for 8 weeks to induce obesity. The modeled mice were divided into four groups and treated with vehicle, rosiglitazone (2 mg/kg), low (100 mg/kg) and high (300 mg/kg) dose of FSH, respectively. Normal control was also used. The treatments were administered orally for 9 weeks. We measured the effect of FSH on regulating body weight, various liver and serum parameters, and molecular targets that are key to lipid metabolism. RESULTS: FSH administration at 100 and 300 mg/kg significantly reduced body weight gain by 33.06 and 43.51%, respectively. Additionally, triglyceride concentration in serum and liver were decreased by 15.67 and 49.56%, individually, after FSH (300 mg/kg) treatment. Upon FSH (100 and 300 mg/kg) treatment, PPARα mRNA expression was upregulated in liver (1.24- and 1.42-fold) and in adipose tissue (1.66- and 1.72-fold). Furthermore, FSH downregulated PPARγ protein level both in liver and adipose tissue. Moreover, FSH inhibited macrophage infiltration into adipose tissues, and downregulated TNFα mRNA expression in adipose tissue (38.01-47.70%). CONCLUSION: This effect was mediated via regulation of PPARγ and PPARα gene expression, and suppression of adipose tissue inflammation.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Flavonoides/uso terapêutico
Hippophae
Hipertrigliceridemia/tratamento farmacológico
Fígado/efeitos dos fármacos
Obesidade/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Peso Corporal/fisiologia
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Hipertrigliceridemia/metabolismo
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/metabolismo
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Sementes
Triglicerídeos/antagonistas & inibidores
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Triglycerides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2016.1278454



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