Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.374 [Categoria DeCS]
Referências encontradas : 18 [refinar]
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  1 / 18 MEDLINE  
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[PMID]:27032067
[Au] Autor:Kim HJ; Kang CH; Jayasooriya RGPT; Dilshara MG; Lee S; Choi YH; Seo YT; Kim GY
[Ad] Endereço:Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea.
[Ti] Título:Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway.
[So] Source:Int Immunopharmacol;35:61-69, 2016 Jun.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We previously demonstrated the anti-inflammatory effect of water extract of Hydrangea macrophylla in lipopolysaccharide (LPS)-stimulated macrophage cells. Here, we investigated whether hydrangenol, a bioactive component of H. macrophylla, attenuates the expression of nitric oxide (NO) and its associated gene, inducible NO synthase (iNOS), in LPS-stimulated BV2 microglial cells. Our data showed that low dosages of hydrangenol inhibited LPS-stimulated NO release and iNOS expression without any accompanying cytotoxicity. Hydrangenol also suppressed LPS-induced nuclear translocation of nuclear factor-κB (NF-κB) subunits, consequently inhibiting DNA-binding activity of NF-κB. Additionally, the NF-κB inhibitors, pyrrolidine dithiocarbamate (PDTC) and PS-1145, significantly attenuated LPS-induced iNOS expression, indicating that hydrangenol-induced NF-κB inhibition might be a key regulator of iNOS expression. Furthermore, our data showed that hydrangenol suppresses NO production by inducing heme oxygenase-1 (HO-1). The presence of cobalt protoporphyrin, a specific HO-1 inducer, potently suppressed LPS-induced NO production. Hydrangenol also promoted nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequently increased its binding activity at the specific antioxidant response element sites. Additionally, transient knockdown of Nrf2 significantly downregulated hydrangenol-induced HO-1 expression, indicating that hydrangenol-induced Nrf2 is an upstream regulator of HO-1. Taken together, these data suggest that hydrangenol attenuates NO production and iNOS expression in LPS-stimulated BV2 microglial cells by inhibiting NF-κB activation and by stimulating the Nrf2-mediated HO-1 signaling pathway. Therefore, hydrangenol is a promising therapeutic agent for treatment of LPS-mediated inflammatory diseases.
[Mh] Termos MeSH primário: Heme Oxigenase-1/metabolismo
Hydrangeaceae/imunologia
Inflamação/tratamento farmacológico
Isocumarinas/farmacologia
Proteínas de Membrana/metabolismo
Microglia/efeitos dos fármacos
Fator 2 Relacionado a NF-E2/metabolismo
NF-kappa B/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Heme Oxigenase-1/genética
Lipopolissacarídeos/imunologia
Proteínas de Membrana/genética
Camundongos
Microglia/imunologia
Fator 2 Relacionado a NF-E2/genética
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
RNA Interferente Pequeno/genética
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isocoumarins); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 0 (RNA, Small Interfering); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); TL8PI7PHV1 (hydrangenol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE


  2 / 18 MEDLINE  
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[PMID]:25776523
[Au] Autor:Kim C; Deng T; Wen J; Nie ZL; Sun H
[Ad] Endereço:Key Laboratory for Plant Biodiversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
[Ti] Título:Systematics, biogeography, and character evolution of Deutzia (Hydrangeaceae) inferred from nuclear and chloroplast DNA sequences.
[So] Source:Mol Phylogenet Evol;87:91-104, 2015 Jun.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genus Deutzia (Hydrangeaceae), containing ca. 60 species circumscribed in three sections, is disjunctly distributed in eastern Asia and Central America (Mexico). Although the genus is well delimited, its subdivisions into sections and series have not been the subject of an explicit test of monophyly based on molecular data. A comprehensive examination of the evolutionary relationships within the genus is thus still lacking. We present a fossil-calibrated, molecular phylogeny of Deutzia based on two nuclear ribosomal DNA (ITS and 26S) and three chloroplast DNA regions (matK, rbcL, and trnL-F intergenic spacer). Within this framework, we examine character evolution in petal arrangement, filament shape, and the number of stamens, and infer the ancestral area and biogeographic history of the genus. Our molecular phylogeny suggests that Deutzia is monophyletic. Two major clades are recovered: one composed of the species of sect. Neodeutzia from Mexico, and the other containing all remaining Deutzia species of sections Mesodeutzia and Deutzia from SW China and Northeast Asia. The latter two Asian sections were each revealed to be polyphyletic. The induplicate petals, 2-dentate filaments, and polystemonous androecia are inferred to be ancestral character states. Biogeographic reconstructions suggest a Northeast Asian origin for the genus and subsequent spread to Mexico during the Oligocene and to SW China during the Miocene. Based on our results, a new infrageneric classification of Deutzia inferred from molecular phylogeny is required. We propose to merge sections Mesodeutzia and Deutzia to ensure the monophyly at the sectional level. Cooling trends during the Oligocene resulted in isolation, separating eastern Asian and Mexican taxa, while the warm period during the middle Miocene stimulated the diversification from Northeast Asia to SW China. The uplift in the Qinghai-Tibetan Plateau and monsoon regimes are important in promoting high species diversification of Deutzia in SW China.
[Mh] Termos MeSH primário: Evolução Biológica
Hydrangeaceae/classificação
Filogenia
[Mh] Termos MeSH secundário: Teorema de Bayes
Núcleo Celular/genética
América Central
China
DNA de Cloroplastos/genética
DNA de Plantas/genética
DNA Ribossômico/genética
Extremo Oriente
Fósseis
Hydrangeaceae/genética
México
Modelos Genéticos
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Plant); 0 (DNA, Ribosomal)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150414
[Lr] Data última revisão:
150414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150318
[St] Status:MEDLINE


  3 / 18 MEDLINE  
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[PMID]:24650862
[Au] Autor:Yuan N; Sun Y; Comes HP; Fu CX; Qiu YX
[Ad] Endereço:Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, and College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
[Ti] Título:Understanding population structure and historical demography in a conservation context: population genetics of the endangered Kirengeshoma palmata (Hydrangeaceae).
[So] Source:Am J Bot;101(3):521-9, 2014 Mar.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Both historical and contemporary microevolutionary processes greatly influence the genetic patterns of East Asian plant endemics, but the spatial and temporal contexts of these processes remain poorly understood. Here, we investigate the relative influences of historical and contemporary gene flow and drift on the population genetic structure of Kirengeshoma palmata, a perennial herb from East China and South Japan. METHODS: We used data from nine polymorphic microsatellite loci to assess the levels of genetic diversity, effective population size, and contemporary and historical gene flow for six of the seven known populations. KEY RESULTS: We found high levels of inbreeding and allelic diversity within populations. Both contemporary and historical migration rates among populations were low, and a test of alternate models of population history strongly favored a model of long-term drift-migration equilibrium. We inferred declines in population size ca. 10,000-100,000 yr ago, but failed to detect recent declines. Bayesian clustering divided K. palmata populations into three genetic clusters, two of which were consistent with a glacial refugium hypothesis for two mountain ranges in East China. CONCLUSIONS: These results suggest that anthropogenic fragmentation has had little effect on the genetic characteristics of Chinese K. palmata. Rather, past decline in population size due to Late Pleistocene climate change as well as restricted pollen and seed dispersal may have contributed to low levels of both historical and contemporary gene flow, resulting in high genetic differentiation between adjacent mountain ranges due to genetic drift and inbreeding.
[Mh] Termos MeSH primário: Fluxo Gênico
Variação Genética
Genética Populacional
Hydrangeaceae/genética
[Mh] Termos MeSH secundário: China
Conservação dos Recursos Naturais
Demografia
Ecossistema
Espécies em Perigo de Extinção
Estruturas Genéticas
Genótipo
Geografia
Hydrangeaceae/fisiologia
Japão
Repetições de Microssatélites/genética
Dispersão de Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140321
[Lr] Data última revisão:
140321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140322
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1400043


  4 / 18 MEDLINE  
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[PMID]:24593236
[Au] Autor:Qi XS; Yuan N; Comes HP; Sakaguchi S; Qiu YX
[Ti] Título:A strong 'filter' effect of the East China Sea land bridge for East Asia's temperate plant species: inferences from molecular phylogeography and ecological niche modelling of Platycrater arguta (Hydrangeaceae).
[So] Source:BMC Evol Biol;14(1):41, 2014 Mar 04.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In East Asia, an increasing number of studies on temperate forest tree species find evidence for migration and gene exchange across the East China Sea (ECS) land bridge up until the last glacial maximum (LGM). However, it is less clear when and how lineages diverged in this region, whether in full isolation or in the face of post-divergence gene flow. Here, we investigate the effects of Quaternary changes in climate and sea level on the evolutionary and demographic history of Platycrater arguta, a rare temperate understorey shrub with disjunct distributions in East China (var. sinensis) and South Japan (var. arguta). Molecular data were obtained from 14 P. arguta populations to infer current patterns of molecular structure and diversity in relation to past (Last Interglacial and Last Glacial Maximum) and present distributions based on ecological niche modelling (ENM). A coalescent-based isolation-with-migration (IM) model was used to estimate lineage divergence times and population demographic parameters. RESULTS: Combining information from nuclear/chloroplast sequence data with nuclear microsatellites, our IM analyses identify the two varieties as genetically distinct units that evolved in strict allopatry since the mid-Pleistocene, c. 0.89 (0.51-1.2) Ma. Together with Bayesian Skyeline Plots, our data further suggest that both lineages experienced post-divergence demographic growth, followed by refugial isolation, divergence, and in the case of var. arguta post-glacial admixture. However, past species distribution modelling indicates that the species' overall distribution has not greatly changed over the last glacial cycles. CONCLUSIONS: Our findings highlight the important influence of ancient sea-level changes on the diversification of East Asia's temperate flora. Implicitly, they challenge the notion of general temperate forest expansion across the ECS land bridge, demonstrating instead its 'filter' effect owing to an unsuitable environment for certain species and their biological (e.g., recruitment) properties.
[Mh] Termos MeSH primário: Hydrangeaceae/classificação
Hydrangeaceae/genética
Filogeografia
[Mh] Termos MeSH secundário: Teorema de Bayes
Evolução Biológica
China
Clima
DNA de Cloroplastos/genética
Fluxo Gênico
Japão
Repetições de Microssatélites
Plantas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140306
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2148-14-41


  5 / 18 MEDLINE  
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[PMID]:23063487
[Au] Autor:Granados Mendoza C; Wanke S; Salomo K; Goetghebeur P; Samain MS
[Ad] Endereço:Ghent University, Department of Biology, Research Group Spermatophytes, KL Ledeganckstraat 35, 9000 Gent, Belgium. Carolina.GranadosMendoza@UGent.be
[Ti] Título:Application of the phylogenetic informativeness method to chloroplast markers: a test case of closely related species in tribe Hydrangeeae (Hydrangeaceae).
[So] Source:Mol Phylogenet Evol;66(1):233-42, 2013 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In evolutionary biology appropriate marker selection for the reconstruction of solid phylogenetic hypotheses is fundamental. One of the most challenging tasks addresses the appropriate choice of genomic regions in studies of closely related species. Robust phylogenetic frameworks are central to studies dealing with questions ranging from evolutionary and conservation biology, biogeography to plant breeding. Phylogenetic informativeness profiles provide a quantitative measure of the phylogenetic signal in markers and therefore a method for locus prioritization. The present work profiles phylogenetic informativeness of mostly non-coding chloroplast regions in an angiosperm lineage of closely related species: the popular ornamental tribe Hydrangeeae (Hydrangeaceae, Cornales, Asterids). A recent phylogenetic study denoted a case of resolution contrast between the two strongly supported clades within tribe Hydrangeeae. We evaluate the phylogenetic signal of 13 highly variable plastid markers for estimating relationships within and among the currently recognized monophyletic groups of this tribe. A selection of combined loci based on their phylogenetic informativeness retrieved more robust phylogenetic hypotheses than simply combining individual markers performing best with respect to resolution, nodal support and accuracy or those presenting the highest number of parsimony informative characters. We propose the rpl32-ndhF intergenic spacer (IGS), trnV-ndhC IGS, trnL-rpl32 IGS, psbT-petB region and ndhA intron as the best candidates for future phylogenetic studies in Hydrangeeae and potentially in other Asterids. We also contrasted the phylogenetic informativeness of coded indels against substitutions concluding that, despite their low phylogenetic informativeness, coded indels provide additional phylogenetic signal that is nearly free of noise. Phylogenetic relationships obtained from our total combined analyses showed improved resolution and nodal support with respect to recently published results.
[Mh] Termos MeSH primário: DNA de Cloroplastos/genética
Hydrangeaceae/classificação
Filogenia
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: DNA de Plantas/genética
Marcadores Genéticos
Hydrangeaceae/genética
Modelos Genéticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:121130
[Lr] Data última revisão:
121130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121016
[St] Status:MEDLINE


  6 / 18 MEDLINE  
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[PMID]:22898876
[Au] Autor:Zhang DF; Sun BB; Yue YY; Zhou QJ; Du AF
[Ad] Endereço:Institute of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
[Ti] Título:Anticoccidial activity of traditional Chinese herbal Dichroa febrifuga Lour. extract against Eimeria tenella infection in chickens.
[So] Source:Parasitol Res;111(6):2229-33, 2012 Dec.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The study was conducted on broiler birds to evaluate the anticoccidial efficacy of an extract of Chinese traditional herb Dichroa febrifuga Lour. One hundred broiler birds were assigned to five equal groups. All birds in groups 1-4 were orally infected with 1.5 × 10(4) Eimeira tenella sporulated oocysts and birds in groups 1, 2 and 3 were medicated with 20, 40 mg extract/kg feed and 2 mg diclazuril/kg feed, respectively. The bloody diarrhea, oocyst counts, intestinal lesion scores, and the body weight were recorded to evaluate the anticoccidial efficacy. The results showed that D. febrifuga extract was effective against Eimeria infection; especially 20 mg D. febrifuga extract/kg feed can significantly increase body weight gains and reduce bloody diarrhea, lesion score, and oocyst excretion in comparison to infected-unmedicated control group.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Coccidiose/veterinária
Eimeria tenella/efeitos dos fármacos
Hydrangeaceae/química
Extratos Vegetais/administração & dosagem
Doenças das Aves Domésticas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/isolamento & purificação
Peso Corporal
Galinhas
China
Coccidiose/tratamento farmacológico
Coccidiose/parasitologia
Coccidiose/patologia
Diarreia/tratamento farmacológico
Diarreia/parasitologia
Diarreia/patologia
Diarreia/veterinária
Eimeria tenella/isolamento & purificação
Medicina Herbária
Oocistos/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Doenças das Aves Domésticas/parasitologia
Doenças das Aves Domésticas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120818
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-012-3071-y


  7 / 18 MEDLINE  
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[PMID]:22837408
[Au] Autor:Qi XS; Yuan N; Qiu YX
[Ad] Endereço:Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Zhejiang University, Hangzhou, People's Republic of China.
[Ti] Título:Development of 12 microsatellite markers for Platycrater arguta (Hydrangeaceae) endemic to East Asia.
[So] Source:Am J Bot;99(8):e304-6, 2012 Aug.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Microsatellite markers were characterized in Platycrater arguta, a rare endemic shrub from eastern China and southern Japan, to investigate its population genetic structure, phylogeographic patterns, and breeding system. METHODS AND RESULTS: Using both the Fast Isolation by AFLP of Sequences COntaining repeats (FIASCO) protocol and the compound microsatellite marker technique, we developed 12 microsatellite markers. All primers showed polymorphism when assessed in 43 individuals from two populations in eastern China and southern Japan. Overall, the number of alleles ranged from five to 21, with an average of 14.91 alleles per locus. CONCLUSIONS: These markers can be used in further studies on population genetics, phylogeography, and breeding system of P. arguta.
[Mh] Termos MeSH primário: Hydrangeaceae/genética
Repetições de Microssatélites/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Alelos
Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Sequência de Bases
Cruzamento
China
Primers do DNA/genética
DNA de Plantas/genética
Loci Gênicos
Marcadores Genéticos
Heterozigoto
Hydrangeaceae/classificação
Japão
Dados de Sequência Molecular
Filogeografia
Folhas de Planta/classificação
Folhas de Planta/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:120809
[Lr] Data última revisão:
120809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120728
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1100582


  8 / 18 MEDLINE  
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[PMID]:19945149
[Au] Autor:Kafel A; Nadgórska-Socha A; Gospodarek J; Babczynska A; Skowronek M; Kandziora M; Rozpedek K
[Ad] Endereço:Department of Animal Physiology and Ecotoxicology, University of Silesia, Bankowa 9, PL 40-007 Katowice, Poland. akafel@us.edu.pl
[Ti] Título:The effects of Aphis fabae infestation on the antioxidant response and heavy metal content in field grown Philadelphus coronarius plants.
[So] Source:Sci Total Environ;408(5):1111-9, 2010 Feb 01.
[Is] ISSN:1879-1026
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to explore a possible relationship between the soil availability of metals and their concentrations in various parts of Philadelphuscoronarius plants. Moreover, the possible impact of an aphid infestation on the contamination and antioxidant response of plants from the urban environment of Kraków and the reference rural area of Zagaje Stradowskie (southern Poland) was analyzed. The contents of the glutathione, proline, non-protein -SH groups, antioxidants, and phosphorous and the levels of guaiacol peroxidase and catalase activity in leaves and shoots either infested or not by the aphid Aphis fabae Scop., were measured. The potential bioavailability of metals (Cd; Cu; Ni; Pb; Zn) in the soil and their concentrations in P. coronarius plants originating from both sites were compared. The antioxidant responses were generally elevated in the plants in the polluted area. Such reactions were additionally changed by aphid infestation. Generally, the concentrations of metals in the HNO(3) and CaCl(2) extractants of the soils from two layers at the 0-20 and 20-40 cm depths from the polluted area were higher than in those from the reference area. Such differences were found for nickel and lead (in all examined extractants), zinc (in soil extractants from the layer at 20-40 cm) and cadmium (in HNO(3) extractants). Significant positive relationships between the lead concentrations in the soil and in the plants were found. In the parts of plants from the polluted area, higher concentrations of Pb and Zn (leaves and shoots) and Cd (shoots) were recorded. The shoots and leaves of plants infested with aphids had higher concentrations of Zn but lower Pb. Moreover, their leaves had higher contaminations of Cu and Ni. In conclusion, aphids affected not only the antioxidant response of the plants but also their contamination with metals, especially contamination of the leaves.
[Mh] Termos MeSH primário: Afídeos/fisiologia
Hydrangeaceae/metabolismo
Metais Pesados/análise
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Animais
Monitoramento Ambiental
Metais Pesados/metabolismo
Folhas de Planta/metabolismo
Brotos de Planta/metabolismo
Polônia
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil Pollutants)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:100129
[Lr] Data última revisão:
100129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091201
[St] Status:MEDLINE
[do] DOI:10.1016/j.scitotenv.2009.11.013


  9 / 18 MEDLINE  
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[PMID]:19607899
[Au] Autor:Park SY; Park GY; Ko WS; Kim Y
[Ad] Endereço:Department of Molecular Biology, College of Natural Sciences, Pusan National University, Jangjeon-dong, Keumjeong-gu, Pusan 609-735, Republic of Korea.
[Ti] Título:Dichroa febrifuga Lour. inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB, MAPK and Akt activation in macrophages.
[So] Source:J Ethnopharmacol;125(2):246-51, 2009 Sep 07.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM OF THE STUDY: The roots of Dichroa febrifuga Lour. have been used as a traditional antimalarial drug and also used in the treatment of productive cough and unstable fever caused by infection in China and Korea. In this study, we evaluated the anti-inflammatory effect and underlying molecular mechanism of aqueous extract of Dichroa febrifuga (AEDF) in C57BL/6 mouse peritoneal macrophages. MATERIALS AND METHODS: The effect of AEDF on proinflammatory cytokine (IL-1beta and IL-6) production was analyzed by ELISA and real-time RT-PCR. The effects of AEDF on NF-kappaB/IkappaB-alpha/IKK were measured by reporter assay (in RAW 264.7 cells), EMSA, Western blotting and kinase assay. The effects of AEDF on Akt and MAPKs activity were assayed by Western blotting. RESULTS: AEDF inhibited the production of IL-1beta and IL-6, NF-kappaB activation, IkappaB-alpha degradation, and IKK, Akt, ERK1/2 and JNK activities in LPS-stimulated mouse peritoneal macrophages. CONCLUSIONS: These results suggest that AEDF inhibits proinflammatory cytokine (IL-1beta and IL-6) production in LPS-stimulated mouse peritoneal macrophages, and that these effects are mediated by the inhibition of the activity of IKK/IkappaB/NF-kappaB and the phosphorylation of Akt, ERK1/2, and JNK. Our results provide a molecular basis for understanding the inhibitory effects of Dichroa febrifuga roots on endotoxin-mediated inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Hydrangeaceae
Interleucina-1beta/antagonistas & inibidores
Interleucina-6/antagonistas & inibidores
NF-kappa B/antagonistas & inibidores
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Proteínas I-kappa B/antagonistas & inibidores
Interleucina-1beta/biossíntese
Interleucina-6/biossíntese
Lipopolissacarídeos
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Proteínas Quinases Ativadas por Mitógeno/antagonistas & inibidores
Inibidor de NF-kappaB alfa
Fosforilação
Raízes de Plantas
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
RNA Mensageiro/biossíntese
RNA Mensageiro/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (I-kappa B Proteins); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Nfkbia protein, mouse); 0 (Plant Extracts); 0 (RNA, Messenger); 139874-52-5 (NF-KappaB Inhibitor alpha); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:0912
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090718
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2009.07.003


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[PMID]:19496955
[Au] Autor:Qiu YX; Sun Y; Zhang XP; Lee J; Fu CX; Comes HP
[Ad] Endereço:Laboratory of Systematic and Evolutionary Botany of Zhejiang University, The Ministry of Education, Hangzhou 310058, China.
[Ti] Título:Molecular phylogeography of East Asian Kirengeshoma (Hydrangeaceae) in relation to quaternary climate change and landbridge configurations.
[So] Source:New Phytol;183(2):480-95, 2009.
[Is] ISSN:1469-8137
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Kirengeshoma comprises two species inhabiting warm temperate-deciduous forests in East China/South Japan (Kirengeshoma palmata) and South Korea (Kirengeshoma koreana). A survey of chloroplast (cp) DNA and inter-simple sequence repeats (ISSRs) variation in Kirengeshoma was carried out to determine the population history of a plant taxon around the East China Sea (ECS). CpDNA and ISSRs revealed lower genetic divergence between China and Japan relative to the other contrasts, in line with intrageneric classification. Molecular dating suggests that K. koreana diverged at the Plio-Pleistocene boundary from the Japanese populations, whereas the latter migrated into China during the early-to-mid Pleistocene via the ECS basin. Vicariant segregation of Chinese and Japanese populations likely occurred during the mid-Pleistocene. Mismatch distributions and neutrality tests indicated that Chinese populations expanded their range during the Late Pleistocene, probably during a cold period, whereas those from Japan showed no significant population growth. We conclude that the current distribution and differentiation of components of presently isolated warm temperate-deciduous forests in China, Japan and Korea likely resulted from a combination of relatively ancient vicariant and immigration events, and those from Japan were particularly sensitive to range fragmentation and long-term refugial isolation throughout the Late Pleistocene.
[Mh] Termos MeSH primário: Clima
Geografia
Hydrangeaceae/genética
Filogenia
[Mh] Termos MeSH secundário: Sequência de Bases
China
DNA de Cloroplastos/genética
Extremo Oriente
Haplótipos
Japão
Repetições de Microssatélites/genética
Dados de Sequência Molecular
Polimorfismo Genético
Dinâmica Populacional
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:090714
[Lr] Data última revisão:
090714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090606
[St] Status:MEDLINE
[do] DOI:10.1111/j.1469-8137.2009.02876.x



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