Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.406 [Categoria DeCS]
Referências encontradas : 271 [refinar]
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[PMID]:29282044
[Au] Autor:Prasansuklab A; Meemon K; Sobhon P; Tencomnao T
[Ad] Endereço:Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
[Ti] Título:Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans.
[So] Source:BMC Complement Altern Med;17(1):551, 2017 Dec 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although such local herb as Streblus asper (family Moraceae) has long been recognized for traditional folk medicines and important ingredient of traditional longevity formula, its anti-neurodegeneration or anti-aging activity is little known. This study aimed to investigate the neuroprotective effect of S. asper leaf extracts (SA-EE) against toxicity of glutamate-mediated oxidative stress, a crucial factor contributing to the neuronal loss in age-associated neurodegenerative diseases and the underlying mechanism as well as to evaluate its longevity effect. METHODS: Using mouse hippocampal HT22 as a model for glutamate oxidative toxicity, we carried out MTT and LDH assays including Annexin V-FITC/propidium iodide staining to determine the SA-EE effect against glutamate-induced cell death. Antioxidant activities of SA-EE were evaluated using the radical scavenging and DCFH-DA assays. To elucidate the underlying mechanisms, SA-EE treated cells were analyzed for the expressions of mRNA and proteins interested by immunofluorescent staining, western blot analysis and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) techniques. The longevity effect of SA-EE was examined on C. elegans by lifespan assay. RESULTS: We demonstrate that a concentration-dependent reduction of glutamate-induced cytotoxicity was significant after SA-EE treatment as measured by MTT and LDH assays. Annexin V-FITC/propidium iodide and immunofluorescent staining showed that co-treatment of glutamate with SA-EE significantly reduced apoptotic-inducing factor (AIF)-dependent apoptotic cell death. DCFH-DA assay revealed that this extract was capable of dose dependently attenuating the ROS caused by glutamate. Western blot analysis and qRT-PCR showed that nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels in the nucleus, as well as mRNA levels of antioxidant-related genes under Nrf2 regulation were significantly increased by SA-EE. Furthermore, this extract was capable of extending the lifespan of C. elegans. CONCLUSIONS: SA-EE possesses both longevity effects and neuroprotective activity against glutamate-induced cell death, supporting its therapeutic potential for the treatment of age-associated neurodegenerative diseases.
[Mh] Termos MeSH primário: Ácido Glutâmico/toxicidade
Moraceae
Neurônios/efeitos dos fármacos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Caenorhabditis elegans
Linhagem Celular
Sobrevivência Celular
Etanol
Hipocampo/citologia
Longevidade/efeitos dos fármacos
Camundongos
Fator 2 Relacionado a NF-E2/metabolismo
Neurônios/citologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Folhas de Planta/química
Substâncias Protetoras/química
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2); 0 (Plant Extracts); 0 (Protective Agents); 3K9958V90M (Ethanol); 3KX376GY7L (Glutamic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2050-3


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[PMID]:28595959
[Au] Autor:Lee W; Lee Y; Jeong GS; Ku SK; Bae JS
[Ad] Endereço:College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
[Ti] Título:Cudratricusxanthone A attenuates renal injury in septic mice.
[So] Source:Food Chem Toxicol;106(Pt A):404-410, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As a natural compound extracted from the roots of Cudrania tricuspidata Bureau, Cudratricusxanthone A (CTXA) is known to possess hepatoprotective, anti-inflammatory, and anti-proliferative activities. This study was aimed to clarify the role of CTXA in modulating renal functional damage in a mouse model of sepsis and to elucidate its underlying mechanisms. We examined the renal protective effects of CTXA on cecal ligation and puncture (CLP)-induced renal damage by assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity. Post-treatment with CTXA resulted in a significant reduction in the deleterious renal functions by CLP, such as elevated BUN, creatinine, and urine protein. Induction of nitric oxide synthase and excessive production of nitric acid by CLP surgery were significantly reduced by post-treatment with CTXA via inhibiting nuclear factor-κB activation. Furthermore, the plasma levels of interleukin-6 and tumor necrosis factor-α were suppressed by CTXA post-treatment. Concurrently, CTXA treatment potently suppressed the CLP-induced septic lethality, rise of lipid peroxidation and markedly enhanced the antioxidant defense system by restoring the levels of superoxide dismutase, glutathione peroxidase, and catalase in kidney. The present results suggested that CTXA could protect against sepsis-triggered renal injury in mice.
[Mh] Termos MeSH primário: Moraceae/química
Extratos Vegetais/administração & dosagem
Sepse/tratamento farmacológico
Xantonas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Modelos Animais de Doenças
Glutationa Peroxidase/genética
Glutationa Peroxidase/metabolismo
Seres Humanos
Interleucina-6/genética
Interleucina-6/metabolismo
Rim/efeitos dos fármacos
Rim/enzimologia
Rim/lesões
Masculino
Camundongos
NF-kappa B/genética
NF-kappa B/metabolismo
Sepse/enzimologia
Sepse/genética
Sepse/metabolismo
Superóxido Dismutase/genética
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Interleukin-6); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Xanthones); 0 (cudratricusxanthone A); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


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[PMID]:28284566
[Au] Autor:He R; Zhang Y; Wu L; Nie H; Huang Y; Liu B; Deng S; Yang R; Huang S; Nong Z; Li J; Chen H
[Ad] Endereço:State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin, 541006
[Ti] Título:Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner.
[So] Source:Phytochemistry;138:170-177, 2017 Jun.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two pairs of rare benzofuran glucoside epimers, indicuses A and B and indicuses C and D, three biogenetically related compounds indicuses E-G, and one coumarin indicus H, as well as 11 known compounds, were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of indicuses A-H were elucidated by NMR and MS data, as well as by CD. (S)-Marmesinin exhibited moderate antimicrobial activity in vitro against Bacillus subtilis and Saccharomyces cerevisiae. 7,8-Dihydroxy-3-(3-methyl-2-butenyl) coumarin, umbelliferone, and scopoletin displayed strong cytotoxic activity in vitro against human bladder carcinoma cell line EJ. The structure-activity relationships indicate that hydroxylation at C-7 in the cytotoxic compounds is crucial to their activities.
[Mh] Termos MeSH primário: Benzofuranos/química
Cumarínicos/química
Glicosídeos/química
Moraceae/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Bacillus subtilis/efeitos dos fármacos
Benzofuranos/isolamento & purificação
Linhagem Celular Tumoral
Cumarínicos/isolamento & purificação
Furanos/química
Furanos/isolamento & purificação
Glicosídeos/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Casca de Planta/química
Extratos Vegetais/química
Saccharomyces cerevisiae/efeitos dos fármacos
Escopoletina/química
Escopoletina/isolamento & purificação
Relação Estrutura-Atividade
Umbeliferonas/química
Umbeliferonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Benzofurans); 0 (Coumarins); 0 (Furans); 0 (Glycosides); 0 (Plant Extracts); 0 (Umbelliferones); 0 (marmesinin); 60Z60NTL4G (7-hydroxycoumarin); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28213269
[Au] Autor:Tian Y; Li Z; Shen B; Zhang Q; Feng H
[Ad] Endereço:Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR China.
[Ti] Título:Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
[So] Source:Int Immunopharmacol;45:148-155, 2017 Apr.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Morin, a bioactive flavonoid extracted from the bark of Moraceae plants and many medicinal herbs, has anti-inflammatory and antioxidative effects. In this research, we explored the protective effects of morin against lipopolysaccharide (LPS) and d-galactosamine (D-GalN) induced acute liver injury in mice. Mice were given an intraperitoneal injection of morin before LPS and D-GalN treatment and the HepG2 cells were only given morin to investigate its effects. The results showed that morin markedly inhibited the production of serum alanine transaminase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), tumor necrosis factor (TNF-α) and hepatic TNF-α, IL-6, and myeloperoxidase (MPO) induced by LPS/D-GalN. In order to evaluate morin effect in the future, we investigated the expression of nuclear factor E2 related factor 2 (Nrf2), nuclear factor-kappaB (NF-κB), toll like receptor 4 (TLR4) on liver injury. Taken together, these results suggested that morin could exert the anti-inflammatory and anti-oxidative effects against LPS/D-GalN-induced acute liver injury by activating Nrf2 signal pathways and inhibiting NF-κB activation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Flavonoides/uso terapêutico
Fígado/efeitos dos fármacos
Fator 2 Relacionado a NF-E2/metabolismo
NF-kappa B/metabolismo
Receptor 4 Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Galactosamina/imunologia
Heme Oxigenase-1/metabolismo
Células Hep G2
Seres Humanos
Lipopolissacarídeos/imunologia
Fígado/patologia
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Moraceae/imunologia
Transdução de Sinais/efeitos dos fármacos
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Flavonoids); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); 7535-00-4 (Galactosamine); 8NFQ3F76WR (morin); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28099090
[Au] Autor:Ogunlaja OO; Moodley R; Baijnath H; Jonnalagadda SB
[Ad] Endereço:a School of Chemistry and Physics, University of KwaZulu-Natal , Durban , South Africa.
[Ti] Título:Nutritional evaluation, bioaccumulation and toxicological assessment of heavy metals in edible fruits of FicussurForssk (Moraceae).
[So] Source:J Environ Sci Health B;52(2):84-91, 2017 Feb.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ficussur (Moraceae) is an indigenous medicinal plant with a wide distribution in Africa. In this study, the nutritional potential fruit of this indigenous plant to meet domestic food demands and reduce food insecurity in KwaZulu-Natal. South Africa, was investigated. The proximate composition and concentrations of metals in the edible fruits collected from eight different sites in KwaZulu-Natal were determined to assess for nutritional value and the concentrations of metals in the growth soil was determined to evaluate the impact of soil quality on elemental uptake. The fruits contained high levels of moisture (88.8%) and carbohydrates (65.6%). The concentrations of elements in the fruits were found to be in decreasing order of Ca>Mg >Fe >Zn>Cu >Mn> Se with low levels of toxic metals (As, Cd, Co and Pb). This study shows that the consumption of the fruits of F. sur can contribute positively to the nutritional needs of rural communities in South Africa for most essential nutrients without posing the risk of adverse health effects.
[Mh] Termos MeSH primário: Frutas/química
Metais Pesados/farmacocinética
Moraceae/química
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Contaminação de Alimentos/análise
Frutas/efeitos dos fármacos
Frutas/metabolismo
Seres Humanos
Metais Pesados/análise
Metais Pesados/toxicidade
Moraceae/efeitos dos fármacos
Moraceae/metabolismo
Valor Nutritivo
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil Pollutants)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2016.1239974


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[PMID]:28076430
[Au] Autor:Zhao K; Wu Y
[Ad] Endereço:School of Environment and Resources, Anqing Normal University, Anqing, P. R. China.
[Ti] Título:Effects of Zn Deficiency and Bicarbonate on the Growth and Photosynthetic Characteristics of Four Plant Species.
[So] Source:PLoS One;12(1):e0169812, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calcareous soils are characterized by low nutrient contents, high bicarbonate (HCO3-) content, and high alkalinity. The effects of HCO3- addition under zinc-sufficient (+Zn) and zinc-deficient (-Zn) conditions on the growth and photosynthetic characteristics of seedlings of two Moraceae species (Broussonetia papyrifera and Morus alba) and two Brassicaceae species (Orychophragmus violaceus and Brassica napus) were investigated. These four species were hydroponically grown in nutrient solution with 0 mM Zn (-Zn) or 0.02 mM Zn (+Zn) and 0 mM or 10 mM HCO3-. The photosynthetic response to HCO3- treatment, Zn deficiency, or both varied according to plant species. Of the four species, Broussonetia papyrifera showed the best adaptability to Zn deficiency for both the 0 mM and 10 mM HCO3- treatments due to its strong growth and minimal inhibition of photosynthesis and photosystem II (PS II). Brassica napus was sensitive to Zn deficiency, HCO3- treatment, or both as evidenced by the considerable inhibition of photosynthesis and high PS II activity. The results indicated different responses of various plant species to Zn deficiency and excess HCO3-. Broussonetia papyrifera was shown to have potential as a pioneer species in karst regions.
[Mh] Termos MeSH primário: Bicarbonatos/metabolismo
Brassicaceae/metabolismo
Moraceae/metabolismo
Solo/química
Zinco/deficiência
[Mh] Termos MeSH secundário: Bicarbonatos/análise
Brassicaceae/crescimento & desenvolvimento
Moraceae/crescimento & desenvolvimento
Fotossíntese
Zinco/análise
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Soil); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169812


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[PMID]:28013566
[Au] Autor:He R; Deng S; Nie H; Huang Y; Liu B; Yang R; Huang S; Zhou D; Chen H; Li J; Zhang Y
[Ad] Endereço:a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
[Ti] Título:Two new coumarins from the bark of Streblus indicus (Bur.) Corner.
[So] Source:Nat Prod Res;31(9):1052-1058, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new coumarins 7-O-(6-O-(5-O-3,4,5-tri-methoxycinnamate-ß-d-apiofuranosyl-ß-d-glucopyranosyl)-6-methoxy coumarin (1) and 7-O-(6-O-(4-(2-hydroxy-1-hydroxymethyl-ethoxy)-3-methoxy-cinnamyl)-ß-d-glucopyranosyl)-6-methoxy coumarin (2), along with 10 known metabolites, were isolated from the bark of Streblus indicus, their structures were identified by comparison of experimental and published spectroscopic data. (S)-marmesinin (6) and scoparone (7) exhibited moderate antimicrobial activity in vitro against Staphylococcus aureus strain with the MIC values of 62.5 and 125.0 µg/mL, respectively. Betulinic acid showed inhibitory activity in vitro against MCF-7 cell with IC value of 9.5 ± 0.1 µM.
[Mh] Termos MeSH primário: Cumarínicos/isolamento & purificação
Moraceae/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Cumarínicos/química
Cumarínicos/farmacologia
Furanos/farmacologia
Seres Humanos
Casca de Planta/química
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Coumarins); 0 (Furans); 0 (marmesinin); H5841PDT4Y (scoparone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1269098


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[PMID]:27983842
[Au] Autor:Ren Y; Chen WL; Lantvit DD; Sass EJ; Shriwas P; Ninh TN; Chai HB; Zhang X; Soejarto DD; Chen X; Lucas DM; Swanson SM; Burdette JE; Kinghorn AD
[Ti] Título:Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.
[So] Source:J Nat Prod;80(3):648-658, 2017 Mar 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three new (1-3) and two known (4 and 5) cytotoxic cardiac glycosides were isolated and characterized from a medicinal plant, Streblus asper Lour. (Moraceae), collected in Vietnam, with six new analogues and one known derivative (5a-g) synthesized from (+)-strebloside (5). A preliminary structure-activity relationship study indicated that the C-10 formyl and C-5 and C-14 hydroxy groups and C-3 sugar unit play important roles in the mediation of the cytotoxicity of (+)-strebloside (5) against HT-29 human colon cancer cells. When evaluated in NCr nu/nu mice implanted intraperitoneally with hollow fibers facilitated with either MDA-MB-231 human breast or OVCAR3 human ovarian cancer cells, (+)-strebloside (5) showed significant cell growth inhibitory activity in both cases, in the dose range 5-30 mg/kg.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Glicosídeos Cardíacos/isolamento & purificação
Glicosídeos Cardíacos/farmacologia
Moraceae/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Glicosídeos Cardíacos/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células HT29
Seres Humanos
Camundongos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Plantas Medicinais
Relação Estrutura-Atividade
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cardiac Glycosides)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00924


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[PMID]:27902844
[Au] Autor:Jo YH; Kim SB; Liu Q; Hwang BY; Lee MK
[Ad] Endereço:College of Pharmacy, Chungbuk National University, Cheongju, Korea.
[Ti] Título:Prenylated Xanthones from the Roots of Cudrania tricuspidata as Inhibitors of Lipopolysaccharide-Stimulated Nitric Oxide Production.
[So] Source:Arch Pharm (Weinheim);350(1), 2017 Jan.
[Is] ISSN:1521-4184
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Investigation of the CH Cl and EtOAc-soluble fractions of the roots of Cudrania tricuspidata afforded 31 compounds. The structures of the isolated compounds were determined on the basis of spectroscopic data interpretation such as 1D and 2D NMR analysis and elucidated as xanthones with prenyl moieties including four simple xanthones (1-4), five prenylated xanthones with one prenyl moiety (5-7, 20, and 21), and 22 prenylated xanthones with two prenyl moieties (8-19 and 22-31). Among them, three diprenylated xanthones named cudracuspixanthones E-G (16, 29, and 31) were first isolated in nature. Xanthones 2, 5, 6, 12, 19, 21, 22, 25, 27, and 28 showed moderate inhibition of lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC values ranging from 16.1 to 24.8 µM.
[Mh] Termos MeSH primário: Lipopolissacarídeos/antagonistas & inibidores
Moraceae/química
Óxido Nítrico/biossíntese
Raízes de Plantas/química
Xantonas/isolamento & purificação
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Lipopolissacarídeos/farmacologia
Camundongos
Estrutura Molecular
Prenilação
Células RAW 264.7/metabolismo
Relação Estrutura-Atividade
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Xanthones); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1002/ardp.201600263


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[PMID]:27649772
[Au] Autor:Tuan Anh HL; Tuan DT; Trang DT; Tai BH; Nhiem NX; Yen PH; Kiem PV; Minh CV; Duc TM; Kang HK; Kim YC; Kim YH
[Ad] Endereço:a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
[Ti] Título:Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation.
[So] Source:J Asian Nat Prod Res;19(5):510-518, 2017 May.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 µM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC 4.3 ± 0.7 to 18.0 ± 1.7 µM).
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Citoproteção/efeitos dos fármacos
Isoflavonas/isolamento & purificação
Isoflavonas/farmacologia
Óxido Nítrico/biossíntese
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Células HL-60
Seres Humanos
Isoflavonas/química
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Moraceae/química
Raízes de Plantas/química
Prenilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Isoflavones); 0 (cudraisoflavone L); 0 (furowanin B); 0 (millewanin H); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1232253



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