Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.406.500 [Categoria DeCS]
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[PMID]:29370854
[Au] Autor:Bopage NS; Kamal Bandara Gunaherath GM; Jayawardena KH; Wijeyaratne SC; Abeysekera AM; Somaratne S
[Ad] Endereço:Department of Chemistry, The Open University of Sri Lanka, Nawala, Nugegoda, Sri Lanka.
[Ti] Título:Dual function of active constituents from bark of Ficus racemosa L in wound healing.
[So] Source:BMC Complement Altern Med;18(1):29, 2018 Jan 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Different parts including the latex of Ficus racemosa L. has been used as a medicine for wound healing in the Ayurveda and in the indigenous system of medicine in Sri Lanka. This plant has been evaluated for its wound healing potential using animal models. The aim of this study was to obtain an insight into the wound healing process and identify the potential wound healing active substance/s present in F. racemosa L. bark using scratch wound assay (SWA) as the in-vitro assay method. METHOD: Stem bark extracts of F. racemosa were evaluated using scratch wound assay (SWA) on Baby Hamster Kidney (BHK 21) and Madin-Darby Canine Kidney (MDCK) cell lines and Kirby Bauer disc diffusion assay on common bacteria and fungi for cell migration enhancing ability and antimicrobial activity respectively. Dichloromethane and hexanes extracts which showed cell migration enhancement activity on SWA were subjected to bioactivity directed fractionation using column chromatography followed by preparative thin layer chromatography to identify the compounds responsible for the cell migration enhancement activity. RESULTS: Dichloromethane and hexanes extracts showed cell migration enhancement activity on both cell lines, while EtOAc and MeOH extracts showed antibacterial activity against Staphylococcus and Bacillus species and antifungal activity against Saccharomyces spp. and Candida albicans. Lupeol (1) and ß-sitosterol (2) were isolated as the potential wound healing active compounds which exhibited significant cell migration enhancement activity on BHK 21 and MDCK cell lines (> 80%) in par with the positive control, asiaticoside at a concentration of 25 µM. The optimum concentration of each compound required for the maximum wound healing has been determined as 30 µM and 35 µM for 1 and 2 respectively on both cell lines. It is also established that lupeol acetate (3) isolated from the hexanes extract act as a pro-drug by undergoing hydrolysis into lupeol in the vicinity of cells. CONCLUSION: Different chemical constituents present in stem bark of Ficus racemosa L show enhancement of cell migration (which corresponds to the cell proliferation) as well as antimicrobial activity. This dual action of F. racemosa stem bark provides scientific support for its traditional use in wound healing.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Ficus/química
Extratos Vegetais/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/química
Bactérias/efeitos dos fármacos
Linhagem Celular
Cães
Fungos/efeitos dos fármacos
Células Madin Darby de Rim Canino
Testes de Sensibilidade Microbiana
Casca de Planta/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2089-9


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[PMID]:28521555
[Au] Autor:Qi CC; Fu YH; Chen WH; Chen GY; Dai CY; Song XP; Han CR
[Ad] Endereço:a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
[Ti] Título:A new isoflavone from the roots of Ficus auriculata.
[So] Source:Nat Prod Res;32(1):43-47, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new isoflavone, 5,7,4'-trihydroxy-3'-hydroxymethylisoflavone (1), together with three known isoflavones, 3'-formyl-5,4'-dihydroxy-7-methoxyisoflavone (2), ficuisoflavone (3) and alpinumisoflavone (4), were isolated from the roots of Ficus auriculata. Among them, 1 is a rare isoflavone containing 16 carbon atoms on the carbon skeleton. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All compounds were evaluated for their antibacterial activities against five terrestrial pathogenic bacteria in vitro. Compounds 1-4 showed significant antibacterial activities against various terrestrial pathogenic bacteria with MIC values ranging from 1.30 to 39.93 µM.
[Mh] Termos MeSH primário: Antibacterianos/química
Ficus/química
Isoflavonas/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Isoflavonas/farmacologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Isoflavones); 6Q33HOF94Z (alpinumisoflavone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1329728


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[PMID]:29337062
[Au] Autor:Yang Y; Zheng K; Mei W; Wang Y; Yu C; Yu B; Deng S; Hu J
[Ad] Endereço:Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
[Ti] Título:Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model.
[So] Source:Biochem Biophys Res Commun;496(2):763-769, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bergapten (5-methoxypsoralen), a coumarin-derivate compound isolated from Ficus hirta roots, was evaluated for its anti-inflammatory and proresolution activities in a tail-cutting-induced zebrafish larvae model. Bergapten was evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(corola: eGFP)" to visualize the effects of the recruitment and clearance of neutrophils and macrophages at the injury site. We found that bergapten significantly suppressed the recruitment of neutrophils and macrophages toward the injury site, as well as promoted the clearance of neutrophils and macrophages from the wound site. We also investigated the reactive oxygen species (ROS) and nitric oxide (NO) level of bergapten in a tail-cutting-induced inflammation zebrafish model. The Results revealed that bergapten effectively inhibited the tail-cutting-induced production of ROS and NO in zebrafish larvae. This study reported for the first time the potential anti-inflammatory and proresolution activities of bergapten in an in vivo zebrafish model, suggesting that bergapten may be a potential candidate for inflammation therapy.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Inflamação/tratamento farmacológico
Macrófagos/efeitos dos fármacos
Metoxaleno/análogos & derivados
Neutrófilos/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Modelos Animais de Doenças
Feminino
Ficus/química
Inflamação/imunologia
Macrófagos/imunologia
Masculino
Metoxaleno/química
Metoxaleno/farmacologia
Neutrófilos/imunologia
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/imunologia
Raízes de Plantas/química
Espécies Reativas de Oxigênio/antagonistas & inibidores
Espécies Reativas de Oxigênio/imunologia
Peixe-Zebra/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide); 4FVK84C92X (5-methoxypsoralen); U4VJ29L7BQ (Methoxsalen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:29179735
[Au] Autor:Foyet HS; Tchinda Deffo S; Koagne Yewo P; Antioch I; Zingue S; Asongalem EA; Kamtchouing P; Ciobica A
[Ad] Endereço:Department of Biological Sciences, Faculty of Science, University of Maroua, Cameroon, P.O. Box: 814, Maroua, Cameroon. fharquins@gmail.com.
[Ti] Título:Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats.
[So] Source:BMC Complement Altern Med;17(1):502, 2017 Nov 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerable to oxidative damage mainly due to its high rate of oxygen consumption, abundant lipid content, and relative insufficiency of antioxidant enzymes. Thus, the identification of neural mechanisms underlying resistance and vulnerability to stress is of crucial importance in understanding the pathophysiology of neuropsychiatric disorders and in developing new treatments, since the existing ones are for several reasons subject to increasing limitations. This study was aimed to assess the effects of hydromethanolic extract of Ficus sycomorus stem bark on depression, anxiety and memory impairment induced by unpredictable chronic mild stress (UCMS) in rats. METHODS: These effects were studied using anxiety-related behavior, depression-related behavior, anhedonia-like behavior and the Y maze task. Sucrose test was performed twice (before and after UCMS) to assess anhedonia in rats. Liquid chromatography-mass spectrometry analysis of the extract were performed. The antioxidant activities of the extract were assessed using total glutathione (GSH) content and malondialdehyde (MDA) level (lipid peroxidation) in the rat temporal lobe homogenates. RESULTS: The extract of F. sycomorus in a dose of 100 mg/kg significantly increased the sucrose consumption and the swimming time which had been reduced by the unpredictable chronic mild stress (p < 0.001). The extract also significantly reduced (p < 0.01) the latency time in the novelty-suppressed feeding test. In the elevated plus-maze, the extract (100 and 200 mg/kg) significantly reduced (p < 0.01) the time and the number of entries into the closed arms. The treatment with the extracts also significantly increased alternation in the Y-maze (p < 0.01 for 100 mg/kg). The extract significantly increased the total GSH content and reduced MDA level in rat temporal lobe. For the LC-MS analysis, the major compound in the extract was a flavonoid with formula C H O . CONCLUSIONS: F. sycomorus reversed the harmful effects of UCMS on mood and behaviors in rats and it possesses an antidepressant property that is at least in part mediated through the oxidative pathway.
[Mh] Termos MeSH primário: Anedonia/efeitos dos fármacos
Comportamento Animal/efeitos dos fármacos
Química Encefálica/efeitos dos fármacos
Ficus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Depressão
Modelos Animais de Doenças
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Wistar
Estresse Psicológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2012-9


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[PMID]:28450590
[Au] Autor:Gibbons A
[Ad] Endereço:New Orleans, Louisiana.
[Ti] Título:In surprise, tooth decay afflicts hunter-gatherers.
[So] Source:Science;356(6336):362, 2017 Apr 28.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cárie Dentária/história
Dieta/efeitos adversos
Saúde Bucal/história
[Mh] Termos MeSH secundário: Antropologia
Cárie Dentária/patologia
Hipoplasia do Esmalte Dentário/história
Hipoplasia do Esmalte Dentário/patologia
Feminino
Ficus/efeitos adversos
História Antiga
Mel/efeitos adversos
Seres Humanos
Masculino
Tanzânia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1126/science.356.6336.362


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[PMID]:29073190
[Au] Autor:Chiu YT; Bain A; Deng SL; Ho YC; Chen WH; Tzeng HY
[Ad] Endereço:Department of Forestry, National Chung- Hsing University, Taichung, Taiwan.
[Ti] Título:Effects of climate change on a mutualistic coastal species: Recovery from typhoon damages and risks of population erosion.
[So] Source:PLoS One;12(10):e0186763, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Presently, climate change has increased the frequency of extreme meteorological events such as tropical cyclones. In the western Pacific basin, these cyclones are called typhoons, and in this area, around Taiwan Island, their frequency has almost doubled since 2000. When approaching landmasses, typhoons have devastating effects on coastal vegetation. The increased frequency of these events has challenged the survival of coastal plant species and their posttyphoon recovery. In this study, a population of coastal gynodioecious Ficus pedunculosa var. mearnsii (Mearns fig) was surveyed for two years to investigate its recovery after Typhoon Morakot, which occurred in August 2009. Similar to all the Ficus species, the Mearns fig has an obligate mutualistic association with pollinating fig wasp species, which requires syconia (the closed Ficus inflorescence) to complete its life cycle. Moreover, male gynodioecious fig species produces both pollen and pollen vectors, whereas the female counterpart produces only seeds. The recovery of the Mearns fig was observed to be rapid, with the production of both leaves and syconia. The syconium:leaf ratio was greater for male trees than for female trees, indicating the importance of syconium production for the wasp survival. Pollinating wasps live for approximately 1 day; therefore, receptive syconia are crucial. Every typhoon season, few typhoons pass by the coasts where the Mearns fig grows, destroying all the leaves and syconia. In this paper, we highlight the potential diminution of the fig population that can lead to the extinction of the mutualistic pair of species. The effects of climate change on coastal species warrant wider surveys.
[Mh] Termos MeSH primário: Mudança Climática
Tempestades Ciclônicas
Ficus/crescimento & desenvolvimento
Modelos Biológicos
Polinização
Vespas
[Mh] Termos MeSH secundário: Animais
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186763


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[PMID]:28866085
[Au] Autor:Wang YK; Li JP; Li TT; Liu R; Jia LY; Wei XQ; Xiao JH; Huang DW
[Ad] Endereço:College of Life Science, Hebei University, Baoding, Hebei 071002, China.
[Ti] Título:Comparative profiling of microRNAs and their association with sexual dimorphism in the fig wasp Ceratosolen solmsi.
[So] Source:Gene;633:54-60, 2017 Oct 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:microRNAs (miRNAs) are small noncoding RNAs that regulate various biological processes, including insect metamorphosis and sexual dimorphism. The fig-pollinating wasp, Ceratosolen solmsi, is a member of the super family Chalcidoidea, which have mutualistic relationships with their fig tree hosts. C. solmsi exhibits extreme sexual dimorphism, which corresponds to the distinct lifestyles of both sexes. Our previous studies showed that these dimorphic characteristics are associated with a dimorphic gene expression pattern. In this study, we constructed six small RNA libraries from female and male wasps in three different developmental stages, i.e., larvae, early pupae, and late pupae. We detected known miRNAs and predicted novel miRNAs, and compared their expression patterns in both sexes and among different developmental stages. We focused mainly on the miRNAs with significantly different expression patterns between sexes and among different life stages, as well as their putative associations with metamorphosis and the formation of sexual dimorphism.
[Mh] Termos MeSH primário: MicroRNAs/genética
Caracteres Sexuais
Vespas/genética
[Mh] Termos MeSH secundário: Animais
Regulação para Baixo
Feminino
Ficus/fisiologia
Perfilação da Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Larva/genética
Larva/crescimento & desenvolvimento
Larva/metabolismo
Masculino
MicroRNAs/metabolismo
Polinização
Biossíntese de Proteínas
Pupa/genética
Pupa/crescimento & desenvolvimento
Pupa/metabolismo
Simbiose
Vespas/crescimento & desenvolvimento
Vespas/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28782581
[Au] Autor:Cheng J; Yi X; Chen H; Wang Y; He X
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
[Ti] Título:Anti-inflammatory phenylpropanoids and phenolics from Ficus hirta Vahl.
[So] Source:Fitoterapia;121:229-234, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new phenylpropanoids (1-4) along with ten known phenolics were isolated and purified from the roots of hairy fig (Ficus hirta Vahl.). Their structures were elucidated by the extensive spectroscopic analysis and chemical degradation. The anti-inflammatory activities of the purified compounds were evaluated. Results indicated that the extracts and some purified compounds exhibited pronounced inhibitory effects on the lipopolysaccharides (LPS) induced nitric oxide (NO) production in murine macrophage RAW 264.7 compared to indomethacin, which suggested that hairy fig could be served as an anti-inflammatory agent for health products.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Ficus/química
Macrófagos/efeitos dos fármacos
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Camundongos
Estrutura Molecular
Óxido Nítrico/metabolismo
Fenóis/isolamento & purificação
Extratos Vegetais/química
Raízes de Plantas/química
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Phenols); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE


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[PMID]:28768532
[Au] Autor:Zingue S; Michel T; Nde CBM; Njuh AN; Cisilotto J; Ndinteh DT; Clyne C; Fernandez X; Creczynski-Pasa TB; Njamen D
[Ad] Endereço:Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon. stephanezingue@gmail.com.
[Ti] Título:Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study.
[So] Source:BMC Complement Altern Med;17(1):383, 2017 Aug 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo. METHODS: To do so, in vitro assays using E-screen and reporter gene were done. In vivo, a 3-day uterotrophic assay followed by a postmenopausal-like rat model to characterize MC as well as F. umbellata aqueous extract in ovariectomized Wistar rats was performed. The investigations focused on histological (vaginal and uterine epithelial height) and morphological (uterine wet weight, vagina stratification and cornification) endpoints, bone mass, biochemical parameters and lipid profile. RESULTS: MC induced a significant (p < 0.05) MCF-7 cell proliferation at a concentration of 0.1 µM, but did not inhibit the effect induced by estradiol in both E-screen and reporter gene assays. In vivo, MC treatment did not show an uterotrophic effect in both rat models used. However, MC (1 mg/kg) induced a significant increase (p < 0.01) of vaginal epithelial height. No significant change was observed with MC in abdominal fat weight, serum lipid levels and bone weight. CONCLUSION: These results suggest that MC has a weak estrogenic activity in vitro and in vivo that accounts only in part to the estrogenicity of the whole plant extract. MC could be beneficial with regard to vagina dryness as it showed a tissue specific effect without exposing the uterus to a potential tumorigenic growth.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Ficus/química
Fitoestrógenos/farmacologia
Extratos Vegetais/farmacologia
Umbeliferonas/farmacologia
Útero/efeitos dos fármacos
Vagina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Inibidores da Aromatase/farmacologia
Osso e Ossos/efeitos dos fármacos
Epitélio/efeitos dos fármacos
Estradiol/metabolismo
Estradiol/farmacologia
Antagonistas de Estrogênios/farmacologia
Feminino
Células HEK293
Seres Humanos
Lipídeos/sangue
Células MCF-7
Ovariectomia
Pós-Menopausa
Ratos Wistar
Útero/metabolismo
Vagina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aromatase Inhibitors); 0 (Estrogen Antagonists); 0 (Estrogens); 0 (Lipids); 0 (Phytoestrogens); 0 (Plant Extracts); 0 (Umbelliferones); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1895-9


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[PMID]:28599242
[Au] Autor:Latayada FS; Uy MM; Akihara Y; Ohta E; Nehira T; Ômura H; Ohta S
[Ad] Endereço:Natural Sciences Department, Caraga State University, Ampayon, Butuan City, 8600, Philippines.
[Ti] Título:Ficusnotins A-F: Rare diarylbutanoids from the leaves of Ficus nota.
[So] Source:Phytochemistry;141:98-104, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Six diarylbutanoids, designated as ficusnotins A-F, with a rare carbon skeleton consisting of two aromatic rings separated by an unbranched C4-chain have been isolated from the leaves of Ficus nota (Blanco) Merr. (Moraceae). The structures were determined on the basis of spectroscopic data, as well as X-ray crystallographic analysis. The isolated compounds were evaluated for their antibacterial activity against Bacillus subtilis.
[Mh] Termos MeSH primário: Ficus/química
Compostos Fitoquímicos/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Bacillus subtilis/efeitos dos fármacos
Estrutura Molecular
Compostos Fitoquímicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Phytochemicals)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE



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