Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.406.633 [Categoria DeCS]
Referências encontradas : 873 [refinar]
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[PMID]:29421517
[Au] Autor:Xue J; Li R; Zhao X; Ma C; Lv X; Liu L; Liu P
[Ad] Endereço:Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong Province, People's Republic of China. Electronic address: 201620468@mail.sdu.edu.cn.
[Ti] Título:Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer.
[So] Source:Chem Biol Interact;283:59-74, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Morusin, a prenylated flavonoid extracted from the root bark of Morus australis, has been reported to exhibit anti-tumor activity against various human cancers except EOC. In the present study, we explored the potential anti-cancer activity of morusin against EOC in vitro and in vivo and possible underlying mechanisms for the first time. We first found that morusin effectively inhibited EOC cell proliferation and survival in vitro and suppressed tumor growth in vivo. Then we observed that treatment of EOC cells with morusin resulted in paraptosis-like cell death, a novel mode of non-apoptotic programmed cell death that is characterized by extensive cytoplasmic vacuolation due to dilation of the endoplasmic reticulum (ER) and mitochondria and lack of apoptotic hallmarks. In addition, we discovered that morusin induced obvious increase in mitochondrial Ca levels, accumulation of ER stress markers, generation of reactive oxygen species (ROS), and loss of mitochondrial membrane potential (Δψm) in EOC cells. Furthermore, pretreatment with 4, 4'-diisothiocyanostilbene-2, 2'-disulfonic acid (DIDS), a chemical inhibitor of voltage-dependent anion channel (VDAC) on the outer mitochondrial membrane, effectively inhibited mitochondrial Ca influx, cytoplasmic vacuolation and cell death induced by morusin in EOC cells. Moreover, DIDS pretreatment also suppressed morusin-induced accumulation of ER stress markers, ROS production and depletion of Δψm. Consistently, tumor xenograft assays showed that co-treatment with DIDS partially reversed the inhibitory effects of morusin on tumor growth in vivo and inhibited the increased levels of ER stress markers induced by morusin in tumor tissues. Collectively, our results suggest that VDAC-mediated Ca influx into mitochondria and subsequent mitochondrial Ca overload contribute to mitochondrial swelling and dysfunction, leading to morusin-induced paraptosis-like cell death in EOC. This study may provide alternative therapeutic strategies for EOC exhibiting resistance to apoptosis.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Cálcio/metabolismo
Flavonoides/farmacologia
Mitocôndrias/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Autofagia/efeitos dos fármacos
Linhagem Celular Tumoral
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Feminino
Flavonoides/química
Flavonoides/uso terapêutico
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Mitocôndrias/metabolismo
Morus/química
Morus/metabolismo
Neoplasias Epiteliais e Glandulares/tratamento farmacológico
Neoplasias Epiteliais e Glandulares/metabolismo
Neoplasias Epiteliais e Glandulares/patologia
Neoplasias Ovarianas/tratamento farmacológico
Neoplasias Ovarianas/metabolismo
Neoplasias Ovarianas/patologia
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Flavonoids); 0 (Reactive Oxygen Species); 62596-29-6 (morusin); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE


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[PMID]:29291443
[Au] Autor:Guo YQ; Tang GH; Lou LL; Li W; Zhang B; Liu B; Yin S
[Ad] Endereço:School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
[Ti] Título:Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba: Isolation, modification, and structure-activity relationship study.
[So] Source:Eur J Med Chem;144:758-766, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The bioassay-guided phytochemical study of a traditional Chinese medicine Morus alba led to the isolation of 18 prenylated flavonoids (1-18), of which (±)-cyclomorusin (1/2), a pair of enantiomers, and 14-methoxy-dihydromorusin (3) are the new ones. Subsequent structural modification of the selected components by methylation, esterification, hydrogenation, and oxidative cyclization led to 14 more derivatives (19-32). The small library was screened for its inhibition against phosphodiesterase-4 (PDE4), which is a drug target for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Among them, nine compounds (1-5, 8, 10, 16, and 17) exhibited remarkable activities with IC values ranging from 0.0054 to 0.40 µM, being more active than the positive control rolipram (IC = 0.62 µM). (+)-Cyclomorusin (1), the most active natural PDE4 inhibitor reported so far, also showed a high selectivity across other PDE members with the selective fold greater than 55. The SAR study revealed that the presence of prenyls at C-3 and/or C-8, 2H-pyran ring D, and the phenolic hydroxyl groups were important to the activity, which was further supported by the recognition mechanism study of the inhibitors with PDE4 by using molecular modeling.
[Mh] Termos MeSH primário: Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo
Flavonoides/farmacologia
Morus/química
Inibidores da Fosfodiesterase 4/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Modelos Moleculares
Estrutura Molecular
Inibidores da Fosfodiesterase 4/química
Inibidores da Fosfodiesterase 4/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phosphodiesterase 4 Inhibitors); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:28521570
[Au] Autor:Li M; Wu X; Wang X; Shen T; Ren D
[Ad] Endereço:a Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , P. R. China.
[Ti] Título:Two novel compounds from the root bark of Morus alba L.
[So] Source:Nat Prod Res;32(1):36-42, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2-4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC less than 10 µM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Benzofuranos/farmacologia
Flavonas/farmacologia
Inibidores de Glicosídeo Hidrolases/farmacologia
Morus/química
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos/química
Benzofuranos/química
Flavonas/química
Flavonoides/química
Flavonoides/farmacologia
Inibidores de Glicosídeo Hidrolases/química
Seres Humanos
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Casca de Planta/química
Espectrometria de Massas por Ionização por Electrospray
Estilbenos/química
Estilbenos/farmacologia
Terpenos/química
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Benzofurans); 0 (Flavones); 0 (Flavonoids); 0 (Glycoside Hydrolase Inhibitors); 0 (Stilbenes); 0 (Terpenes); 0 (licoflavone C); 0 (moracin C); 62596-29-6 (morusin); 87085-00-5 (mulberrofuran G)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1327862


  4 / 873 MEDLINE  
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[PMID]:29275228
[Au] Autor:Mascarello A; Orbem Menegatti AC; Calcaterra A; Martins PGA; Chiaradia-Delatorre LD; D'Acquarica I; Ferrari F; Pau V; Sanna A; De Logu A; Botta M; Botta B; Terenzi H; Mori M
[Ad] Endereço:Centro de Biologia Molecular Estrutural, CEBIME-UFSC, Universidade Federal de Santa Catarina, Campus Trindade, 88040-900, Florianopolis, SC, Brazil; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le Aldo Moro 5, 00185, Roma, Italy.
[Ti] Título:Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
[So] Source:Eur J Med Chem;144:277-288, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatases A and B (PtpA and PtpB) have been recognized as potential molecular targets for the development of new therapeutic strategies against tuberculosis (TB). In this context, we have recently reported that the naturally occurring Diels-Alder-type adduct Kuwanol E is an inhibitor of PtpB (K = 1.6 ± 0.1 µM). Here, we describe additional Diels-Alder-type adducts isolated from Morus nigra roots bark that inhibit PtpB at sub-micromolar concentrations. The two most potent compounds, namely Kuwanon G and Kuwanon H, showed K values of 0.39 ± 0.27 and 0.20 ± 0.01 µM, respectively, and interacted with the active site of the enzyme as suggested by kinetics and mass spectrometry studies. Molecular docking coupled with intrinsic fluorescence analysis and isothermal titration calorimetry (ITC) further characterized the interaction of these promising PtpB inhibitors. Notably, in an Mtb survival assay inside macrophages, Kuwanon G showed inhibition of Mtb growth by 61.3%. All these results point to the common Diels-Alder-type adduct scaffold, and highlight its relevance for the development of PtpB inhibitors as candidate therapeutics for TB.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Flavonoides/farmacologia
Morus/química
Mycobacterium tuberculosis/enzimologia
Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Linhagem Celular
Reação de Cicloadição
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Cinética
Modelos Moleculares
Estrutura Molecular
Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Flavonoids); 0 (kuwanol E); EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


  5 / 873 MEDLINE  
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[PMID]:29210099
[Au] Autor:Fuller G; Murray A; Thueme M; McGuire M; Vonk J; Allard S
[Ad] Endereço:Center for Zoo Animal Welfare and Ethics, Detroit Zoological Society, Royal Oak, Michigan.
[Ti] Título:Behavioral and hormonal responses to the availability of forage material in Western lowland gorillas (Gorilla gorilla gorilla).
[So] Source:Zoo Biol;37(1):23-34, 2018 Jan.
[Is] ISSN:1098-2361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated how forage material affects indicators of welfare in three male Western lowland gorillas (Gorilla gorilla gorilla) at the Detroit Zoo. In addition to their maintenance diet and enrichment foods, the gorillas generally received forage material four times a week. From this baseline, we systematically manipulated how much forage material the group received on a weekly basis, with either daily or bi (twice)-weekly presentation of browse (mulberry, Morus sp.) or alfalfa hay. We collected behavioral data (60 hr per gorilla) and measured fecal glucocorticoid metabolites (FGM). Mixed models indicated that the presence of forage material significantly increased time feeding (F = 9.58, p < 0.001), and decreased rates of noncontact aggression (F = 3.69, p = 0.03), and regurgitation and reingestion (F = 4.70, p = 0.01). Regurgitation and reingestion were never observed during the condition when forage material was provided daily. When forage material was provided, time spent feeding was similar across gorillas, compared to a disproportionately greater amount of time spent feeding by the dominant individual when forage material was absent. Providing forage material in addition to the regular diet likely created more opportunities for equitable feeding for the subordinate gorillas. FGM concentrations did not vary based on the presence or type of forage material available and, instead, likely reflected group social dynamics. In general, alfalfa and mulberry had similar impacts on behavior, indicating that alfalfa can be an adequate behavioral substitute during times when browse is less readily available for gorillas housed in seasonally variable climates.
[Mh] Termos MeSH primário: Ração Animal/análise
Comportamento Animal
Glucocorticoides/metabolismo
Gorilla gorilla
Medicago sativa
Morus
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Animais de Zoológico
Fezes/química
Glucocorticoides/química
Masculino
Atividade Motora
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1002/zoo.21393


  6 / 873 MEDLINE  
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[PMID]:29277319
[Au] Autor:Fan W; Guo Q; Liu C; Liu X; Zhang M; Long D; Xiang Z; Zhao A
[Ad] Endereço:State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, Chongqing 400716, China.
[Ti] Título:Two mulberry phytochelatin synthase genes confer zinc/cadmium tolerance and accumulation in transgenic Arabidopsis and tobacco.
[So] Source:Gene;645:95-104, 2018 Mar 01.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytochelatin synthase (PCS) is an enzyme involved in the synthesis of phytochelatins, cysteine-rich peptides which play a key role in heavy metal (HM) detoxification of plants. Mulberry (Morus L.), one of the most ecologically and economically important tree genera, has the potential to remediate HM-contaminated soils. However, genes involved in HM detoxification in Morus, such as the PCS genes, have not been identified and characterized. In this study, we identified two Morus notabilis PCS genes based on a genome-wide analysis of the Morus genome database. Full-length MnPCS1 and MnPCS2 cDNAs were 1509 and 1491bp long, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed that, under 200µM Zn or either 30 or 100µM Cd stress, the relative expression of each of the two MaPCSs (from Morus alba) was induced in root, stem and leaf tissues within 24h of exposure to the metals, with Cd inducing expression more strongly than did Zn . Based on the analysis of total root length and fresh weight of seedlings, overexpression of MnPCS1 and MnPCS2 in Arabidopsis and tobacco enhanced Zn /Cd tolerance in most transgenic individuals. The results of transgenic Arabidopsis lines overexpressing MnPCS1and MnPCS2 suggest that MnPCS1 play a more important role in Cd detoxification than MnPCS2. Zn /Cd concentrations in both shoots and roots of the transgenic Arabidopsis seedlings were higher than in wild type (WT) seedlings at two Zn /Cd concentrations. In addition, there was a positive correlation between Zn accumulation and the expression level of MnPCS1 or MnPCS2. Our results indicated that the Morus PCS1 and PCS2 genes play important roles in HM stress tolerance and accumulation, providing a useful genetic resource for enhancing tolerance to HMs and for increasing the HM phytoremediation potential of these plants.
[Mh] Termos MeSH primário: Aminoaciltransferases/genética
Arabidopsis/genética
Morus/enzimologia
Tabaco/genética
[Mh] Termos MeSH secundário: Aminoaciltransferases/metabolismo
Arabidopsis/crescimento & desenvolvimento
Cádmio/metabolismo
Regulação da Expressão Gênica de Plantas
Morus/genética
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Raízes de Plantas/genética
Brotos de Planta/genética
Plantas Geneticamente Modificadas/crescimento & desenvolvimento
Estresse Fisiológico
Tabaco/crescimento & desenvolvimento
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 00BH33GNGH (Cadmium); EC 2.3.2.- (Aminoacyltransferases); EC 2.3.2.15 (glutathione gamma-glutamylcysteinyltransferase); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  7 / 873 MEDLINE  
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[PMID]:29274907
[Au] Autor:Guan Q; Yu J; Zhu W; Yang B; Li Y; Zhang L; Tian J
[Ad] Endereço:College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, PR China.
[Ti] Título:RNA-Seq transcriptomic analysis of the Morus alba L. leaves exposed to high-level UVB with or without dark treatment.
[So] Source:Gene;645:60-68, 2018 Mar 01.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ultraviolet-B (UVB) irradiation induces oxidative stress in plant cells due to the generation of excessive reactive oxygen species. Morus alba L. (M. abla) is an important medicinal plant used for the treatment of human diseases. Also, its leaves are widely used as food for silkworms. In our previous research, we found that a high level of UVB irradiation with dark incubation led to the accumulation of secondary metabolites in M. abla leaf. The aim of the present study was to describe and compare M. alba leaf transcriptomics with different treatments (control, UVB, UVB+dark). Leaf transcripts from M. alba were sequenced using an Illumina Hiseq 2000 system, which produced 14.27Gb of data including 153,204,462 paired-end reads among the three libraries. We de novo assembled 133,002 transcripts with an average length of 1270bp and filtered 69,728 non-redundant unigenes. A similarity search was performed against the non-redundant National Center of Biotechnology Information (NCBI) protein database, which returned 41.08% hits. Among the 20,040 unigenes annotated in UniProtKB/SwissProt database, 16,683 unigenes were assigned 102,232 gene ontology terms and 6667 unigenes were identified in 287 known metabolic pathways. Results of differential gene expression analysis together with real-time quantitative PCR tests indicated that UVB irradiation with dark incubation enhanced the flavonoid biosynthesis in M. alba leaf. Our findings provided a valuable proof for a better understanding of the metabolic mechanism under abiotic stresses in M. alba leaf.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica/métodos
Morus/efeitos da radiação
Proteínas de Plantas/genética
Análise de Sequência de RNA/métodos
[Mh] Termos MeSH secundário: Bases de Dados de Proteínas
Flavonoides/biossíntese
Regulação da Expressão Gênica de Plantas/efeitos da radiação
Ontologia Genética
Morus/genética
Morus/metabolismo
Folhas de Planta/genética
Folhas de Planta/efeitos da radiação
Proteínas de Plantas/efeitos da radiação
Reação em Cadeia da Polimerase em Tempo Real
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


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[PMID]:29231728
[Au] Autor:Woo H; Lee J; Park D; Jung E
[Ad] Endereço:Biospectrum Life Science Institute , A-1805, U-Tower, 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do Republic of Korea.
[Ti] Título:Protective Effect of Mulberry (Morus alba L.) Extract against Benzo[a]pyrene Induced Skin Damage through Inhibition of Aryl Hydrocarbon Receptor Signaling.
[So] Source:J Agric Food Chem;65(50):10925-10932, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Benzo[a]pyrene (B[a]P), a type of polycyclic aromatic hydrocarbon, is present in the atmosphere surrounding our environment. Although B[a]P is a procarcinogen, enzymatically metabolized benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) could intercalate into DNA to form bulky BPDE-DNA adducts as an ultimate carcinogenic product in human keratinocytes. The aim of this study was to evaluate the protective effect of mulberry extract, purified from the fruit of Morus Alba L., on B[a]P-induced cytotoxicity in human keratinocytes and its mechanisms of action. In this study, we confirmed that B[a]P induced nuclear translocation and the activation of aryl hydrocarbon receptor (AhR) were decreased by pretreatment of mulberry extract. Mulberry extract could decrease DNA damage through the suppression of B[a]P derived DNA adduct formation and restoration of cell cycle retardation at S phase in a dose-dependent manner. Additionally, cyanidin-3-glucoside (C3G), a major active compound of mulberry extract, showed biological activities to protect the cells from B[a]P exposure, similar to the effectivity of the mulberry extract. These results indicated that the inhibitory effect of C3G against B[a]P inducing skin cancer is attributable to repress the AhR signaling pathway.
[Mh] Termos MeSH primário: Benzo(a)pireno/toxicidade
Morus/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
Receptores de Hidrocarboneto Arílico/metabolismo
Transdução de Sinais/efeitos dos fármacos
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antocianinas/farmacologia
Adutos de DNA/genética
Adutos de DNA/metabolismo
Dano ao DNA/efeitos dos fármacos
Feminino
Glucosídeos/farmacologia
Seres Humanos
Técnicas In Vitro
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Meia-Idade
Receptores de Hidrocarboneto Arílico/antagonistas & inibidores
Receptores de Hidrocarboneto Arílico/genética
Pele/citologia
Pele/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (DNA Adducts); 0 (Glucosides); 0 (Plant Extracts); 0 (Protective Agents); 0 (Receptors, Aryl Hydrocarbon); 3417WMA06D (Benzo(a)pyrene); 7084-24-4 (cyanidin 3-O-glucoside)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04044


  9 / 873 MEDLINE  
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[PMID]:29210238
[Au] Autor:Diez JM; Ibáñez I; Silander JA; Primack R; Higuchi H; Kobori H; Sen A; James TY
[Ti] Título:Beyond seasonal climate: statistical estimation of phenological responses to weather.
[So] Source:Ecol Appl;24(7):1793-802, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phenological events, such as the timing of flowering or insect emergence, are influenced by a complex combination of climatic and non-climatic factors. Although temperature is generally considered most important, other weather events such as frosts and precipitation events can also influence many species' phenology. Non-climatic variables such as photoperiod and site-specific habitat characteristics can also have important effects on phenology. Forecasting phenological shifts due to climate change requires understanding and quantifying how these multiple factors combine to affect phenology. However, current approaches to analyzing phenological data have a limited ability for quantifying multiple drivers simultaneously. Here, we use a novel statistical approach to estimate the combined effects of multiple variables, including local weather events, on the phenology of several taxa (a tree, an insect, and a fungus). We found that thermal forcing had a significant positive effect on each species, frost events delayed the phenology of the tree and butterfly, and precipitation had a positive effect on fungal fruiting. Using data from sites across latitudinal gradients, we found that these effects are remarkably consistent across sites once latitude and other site effects are accounted for. This consistency suggests an underlying biological response to these variables that is not commonly estimated using data from field observations. This approach's flexibility will be useful for forecasting ongoing phenological responses to changes in climate variability in addition to seasonal trends.
[Mh] Termos MeSH primário: Ascomicetos/fisiologia
Modelos Biológicos
Morus/fisiologia
Mariposas/fisiologia
Estações do Ano
Tempo (Meteorologia)
[Mh] Termos MeSH secundário: Animais
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29199592
[Au] Autor:Gupta G; Chellappan DK; Kikuchi IS; Pinto TJA; Pabreja K; Agrawal M; Singh Y; Tiwari J; Dua K
[Ad] Endereço:Jaipur National University, School of Pharmaceutical Sciences, Jagatpura, 302017, Jaipur, India; University of Newcastle, School of Medicine and Public Health, Newcastle, NSW 2308, Australia.
[Ti] Título:Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside.
[So] Source:J Environ Pathol Toxicol Oncol;36(2):113-119, 2017.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.
[Mh] Termos MeSH primário: Acetaminofen/toxicidade
Analgésicos não Entorpecentes/toxicidade
Rim/efeitos dos fármacos
Morus/química
Substâncias Protetoras/farmacologia
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Casca de Planta/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Plant Extracts); 0 (Protective Agents); 0 (Steroids); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1615/JEnvironPatholToxicolOncol.2017019457



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