Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.437 [Categoria DeCS]
Referências encontradas : 157 [refinar]
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[PMID]:28704688
[Au] Autor:Boucherle B; Peuchmaur M; Boumendjel A; Haudecoeur R
[Ad] Endereço:Univ. Grenoble-Alpes, CNRS, DPM UMR 5063, CS 40700, 38058, Grenoble, France.
[Ti] Título:Occurrences, biosynthesis and properties of aurones as high-end evolutionary products.
[So] Source:Phytochemistry;142:92-111, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Recent years have witnessed a considerable renewed interest for the uncommon flavonoid class of aurones. The characterization of two major biosynthetic machineries involved in their biosynthesis in flowers has encouraged the revival of phytochemical studies and identification of original structures, a process started almost seventy-five years ago. This review draws up an exhaustive map of natural occurrences of aurones their biosynthetic pathways and roles, with the aim to link their original structural properties among flavonoids to their place in evolution and the selective advantages they bring to some of the most advanced taxa in the plant kingdom.
[Mh] Termos MeSH primário: Benzofuranos/química
Produtos Biológicos
Flavonoides/química
[Mh] Termos MeSH secundário: Anacardiaceae/química
Produtos Biológicos/química
Fabaceae/química
Flores/química
Estrutura Molecular
Rhamnaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzofurans); 0 (Biological Products); 0 (Flavonoids); 0 (aurone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


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[PMID]:28686899
[Au] Autor:Kang KB; Jun JB; Kim JW; Kim HW; Sung SH
[Ad] Endereço:College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
[Ti] Título:Ceanothane- and lupane-type triterpene esters from the roots of Hovenia dulcis and their antiproliferative activity on HSC-T6 cells.
[So] Source:Phytochemistry;142:60-67, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three ceanothane-type and three lupane-type triterpenoids, as well as three known compounds, were isolated from the roots of Hovenia dulcis (Rhamnaceae), based on LC-MS dereplication. The previously undescribed compounds were determined to be 27-O-protocatechuoyl-3-dehydroxyisoceanothanolic acid, 27-O-protocatechuoyl-3-dehydroxycolubrinic acid, 27-O-protocatechuoyl-3-dehydroxyepicolubrinic acid, 27-O-protocatechuoylbetulinic acid, 27-O-p-hydroxybenzoylbetulinic acid, and 27-O-syringoylbetulinic acid by 1D and 2D NMR spectroscopic and HR mass spectrometric data analysis. The isolates were examined for their antiproliferative activity in HSC-T6 hepatic stellate cells; compounds 1, 2, 3, and 6 showed IC values in the range of 15-50 µM.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Raízes de Plantas/química
Rhamnaceae/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Enterococcus faecalis/efeitos dos fármacos
Ésteres
Concentração Inibidora 50
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Staphylococcus aureus/efeitos dos fármacos
Triterpenos/química
Triterpenos/classificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (27-O-protocatechuoyl-3-dehydroxycolubrinic acid); 0 (27-O-protocatechuoyl-3-dehydroxyepicolubrinic acid); 0 (27-O-protocatechuoyl-3-dehydroxyisoceanothanolic acid); 0 (Anti-Bacterial Agents); 0 (Esters); 0 (Triterpenes); 0 (ceanothane); 464-99-3 (lupane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28652183
[Au] Autor:Shao F; Lu Q; Wilson IW; Qiu D
[Ad] Endereço:State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of State Forestry Administration, The Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.
[Ti] Título:Genome-wide identification and characterization of the SPL gene family in Ziziphus jujuba.
[So] Source:Gene;627:315-321, 2017 Sep 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:SQUAMOSA Promoter-Binding Protein-Likes (SPLs) are plant specific transcription factors playing important roles in plant growth and development. The SPL gene family has been studied in various plant species; however, there is no report about SPLs in Zizyphus jujuba. In this study, we identified 18 putative ZjSPL genes in Z. jujuba using a genome-wide analysis. Sequence features, gene structures, conserved domains and motifs were analyzed. The phylogenetic relationships of SPLs in Z. jujuba and A. thaliana were revealed. A total of 5 pairs of ZjSPLs were identified, suggesting the importance of gene duplication in SPL gene expansion in Z. jujuba. In addition, 11 of the 18 ZjSPLs, belonging to G1, G2 and G5 subgroups, were found to be targets of miR156, suggesting the conservation of miR156-mediated posttranscriptional regulation in plants. Expression analysis revealed that eight ZjSPL genes were responsive to the infection of witches'-broom phytoplasma. Our results provide a basis for the further elucidation of the biological function of ZjSPLs and their regulation in witches'-broom disease.
[Mh] Termos MeSH primário: Proteínas de Ligação a DNA/genética
Genoma de Planta
Proteínas de Plantas/genética
Rhamnaceae/genética
[Mh] Termos MeSH secundário: Proteínas de Ligação a DNA/química
Regulação da Expressão Gênica de Plantas
MicroRNAs/genética
Phytoplasma/patogenicidade
Imunidade Vegetal/genética
Proteínas de Plantas/química
Domínios Proteicos
Rhamnaceae/classificação
Rhamnaceae/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (MicroRNAs); 0 (Plant Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28614728
[Au] Autor:Muhammad D; Lalun N; Bobichon H; Le Magrex Debar E; Gangloff SC; Nour M; Voutquenne-Nazabadioko L
[Ad] Endereço:UMR CNRS 7312, Université de Reims Champagne-Ardenne, Bât. 18, Moulin de la Housse, BP 1039, 51687 Reims, Cedex 2, France.
[Ti] Título:Triterpenoid saponins and other glycosides from the stems and bark of Jaffrea xerocarpa and their biological activity.
[So] Source:Phytochemistry;141:121-130, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Six previously undescribed triterpenoid saponins and two previously undescribed norlupane triterpenes were isolated with five known saponins, three known lupane derivatives, 17,20-didehydro-20-deoxyjujubogenin, rutin, (±) 3α-O-ß-d-glucopyranosyl-lyoniresinol, (±) 4-O-ß-d-glucopyranosyl-maesopsin, three phenol glycosides, and uridine from the stems and bark of Jaffrea xerocarpa (Baill.) H. C. Hopkins & Pillon (= Basionym Alphitonia xerocarpus Baill.) (Rhamnaceae), an endemic tree of New Caledonia. The chemical structures of the purified compounds were identified by nuclear magnetic resonance and mass spectrometry. The isolated compounds were tested for their antioxidant, antityrosinase, antibacterial and cytotoxic activities. The aqueous methanol extract showed antioxidant activity (DPPH assay) due to the presence of rutin and other phenolic compounds. Three lupane triterpenes showed good cytotoxic activities against KB cells line (IC from 7.7 to 8.5 µM). The previously undescribed 2α-formyl-A(1)norlup-20(29)-en-28-oic acid showed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with both MIC values of 4 µg/mL.
[Mh] Termos MeSH primário: Rhamnaceae/química
Saponinas/química
Triterpenos/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Enterococcus faecalis/efeitos dos fármacos
Seres Humanos
Células KB
Testes de Sensibilidade Microbiana
Estrutura Molecular
Casca de Planta/química
Caules de Planta/química
Saponinas/isolamento & purificação
Staphylococcus aureus/efeitos dos fármacos
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Saponins); 0 (Triterpenes); 464-99-3 (lupane)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


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[PMID]:28446228
[Au] Autor:Zor M; Aydin S; Güner ND; Basaran N; Basaran AA
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Bülent Ecevit University, 67100, Zonguldak, Turkey.
[Ti] Título:Antigenotoxic properties of Paliurus spina-christi Mill fruits and their active compounds.
[So] Source:BMC Complement Altern Med;17(1):229, 2017 Apr 26.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Paliurus spina-christi Mill. (PS) fruits are widely used for different medical purposes in Turkey. Like in many medicinal herbs the studies concerning their activity, the activities of PS are also not well clarified. The aim of this study is to evaluate the antigenotoxicity of the compounds isolated and identified from the extracts of PS fruits. METHODS: The active compounds were separated, isolated, and determined by chromatographic methods and their structural elucidation was performed by Nuclear Magnetic Resonance (NMR) methods. The compounds were obtained from either ethyl acetate (EA) or n-butanol extracts. The cytotoxicities of the compounds using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the antigenotoxic activities of the compounds using the alkaline single cell gel electrophoresis techniques (comet assay) were evaluated in Chinese hamster lung fibroblast (V79) cell lines. RESULTS: The isolated major compounds were identified as (+/-) catechins and gallocatechin from EA fraction and rutin from n-butanol fraction of PS fruits. Their chemical structures were identified by H-NMR, C-NMR, HMBC, and HMQC techniques. Half-maximal inhibitory concentration of catechins, gallocatechin, and rutin were found to be 734 µg/mL, 220 µg/mL, and 1004 µg/mL, respectively. The methanolic extract of PS (1-100 µg/mL) alone did not induce DNA single-strand breaks while catechins (1-100 µg/mL), gallocatechin (1-50 µg/mL), and rutin (1-50 µg/mL) significantly reduced H O -induced DNA damage. CONCLUSION: It has been suggested that PS fruits and their compounds catechins, gallocatechin and rutin may have beneficial effects in oxidative DNA damage. It seems that PS fruits may be used in protection of the disorders related to DNA damage.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Catequina/farmacologia
Dano ao DNA/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Rhamnaceae/química
Rutina/farmacologia
[Mh] Termos MeSH secundário: Animais
Catequina/análogos & derivados
Catequina/isolamento & purificação
Linhagem Celular Tumoral
Ensaio Cometa
Cricetinae
Frutas/química
Células Hep G2
Seres Humanos
Peróxido de Hidrogênio/metabolismo
Estrutura Molecular
Fitoterapia
Extratos Vegetais/química
Rutina/isolamento & purificação
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 5G06TVY3R7 (Rutin); 7Z197MG6QL (gallocatechol); 8R1V1STN48 (Catechin); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1732-1


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[PMID]:28105505
[Au] Autor:Nouioui I; Del Carmen Montero-Calasanz M; Ghodhbane-Gtari F; Rohde M; Tisa LS; Klenk HP; Gtari M
[Ad] Endereço:Laboratoire Microorganismes et Biomolécules Actives, Université Tunis El Manar (FST) & Université de Carthage (INSAT), 2092, Tunis, Tunisia.
[Ti] Título:Frankia discariae sp. nov.: an infective and effective microsymbiont isolated from the root nodule of Discaria trinervis.
[So] Source:Arch Microbiol;199(5):641-647, 2017 Jul.
[Is] ISSN:1432-072X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Strain BCU110501 was the first isolate reported to fulfill Koch's postulates by inducing effective nodules on its host plant of origin Discaria trinervis (Rhalmnaceae). Based on 16S rRNA gene sequence similarities, the strain was found to be most closely related to the type strain of Frankia elaeagni DSM 46783 (98.6%) followed by F. alni DSM 45986 (98.2%), F. casuarinae DSM 45818 (97.8%) and F. inefficacies DSM 45817 (97.8%). Digital DNA:DNA hybridizations (dDDH) between strain BCU110501 and the type strains of other Frankia species were clearly below the cutoff point of 70%. The G+C content of DNA is 72.36%. The cell wall of strain BCU110501 contained meso-diaminopimelic acid and the cell sugars were galactose, glucose, mannose, xylose and ribose. Polar lipids were phosphatidylinositol (PI), diphosphatidylglycerol (DPG), glycophospholipid (GPL ), phosphatidylglycerol (PG) and an unknown lipid (L). The major fatty acids of strain BCU110501 consisted of iso-C16:0, C17:1 w8c and C16:0. Major menaquinones were MK9 (H ), MK9 (H ) and MK9 (H ). Based on these analyses, strain BCU110501 (=DSM 46785 =CECT 9042 ) should be classified as the type strain of a novel Frankia species, for which the name Frankia discariae sp. nov. is proposed.
[Mh] Termos MeSH primário: Frankia
Rhamnaceae/microbiologia
Nódulos Radiculares de Plantas/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases/genética
Sequência de Bases
Parede Celular/química
DNA Bacteriano/genética
Ácido Diaminopimélico/metabolismo
Ácidos Graxos/análise
Frankia/classificação
Frankia/genética
Frankia/isolamento & purificação
Hibridização de Ácido Nucleico
Filogenia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S); 583-93-7 (Diaminopimelic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1007/s00203-017-1337-6


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[PMID]:28039787
[Au] Autor:Boligon AA; da Rosa Moreira L; Piana M; de Campos MM; Oliveira SM
[Ad] Endereço:Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Avenida Roraima 1000, Camobi Campus, Santa Maria, RS 97105-900, Brazil. Electronic address: alineboligon@hotmail.com.
[Ti] Título:Topical antiedematogenic and anti-inflammatory effect of Scutia buxifolia Reissek gel and stability study.
[So] Source:J Photochem Photobiol B;167:29-35, 2017 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Scutia buxifolia Reissek (Rhamnaceae), popularly known in Brazil as "coronilha", is a plant species used in folk medicine for several disorders, including inflammation. However, no studies have been done with this species to confirm its topical anti-inflammatory action. In this study we evaluate the topical antiedematogenic and anti-inflammatory effects of the gel containing crude extract (CE) and the gel containing ethyl acetate (EtOAc) fraction of S. buxifolia on croton oil or UVB radiation-induced ear edema in mice, and perform gel stability study. Antiedematogenic and anti-inflammatory effects were evaluated through ear edema induced by irritant agent croton oil, UVB irradiation-induced skin injury model and neutrophil infiltration. The gel stability study was performed by analyzing organoleptical aspects, pH, viscosity, and quantification of quercetin and rutin by HPLC. The topical treatment with S. buxifolia gel reduced the ear edema and myeloperoxidase activity. Antiedematogenic and anti-inflammatory effects of S. buxifolia were obtained with concentrations of 0.3, 1 and 3%, with maximal inhibition in the concentration of 1% for gel containing CE (inhibitions of 100, 73±0.05 and 97±0.08% for croton oil- or UVB irradiation-induced ear edema and myeloperoxidase activity, respectively) and EtOAc fraction (inhibitions of 79±0.05, 73±0.05 and 89±0.04% for croton oil- or UVB irradiation-induced ear edema and myeloperoxidase activity, respectively). Such effects may be attributed, at least in part, to rutin and quercetin, as well as other compounds found in this species. No important changes were detected in the stability study, in all aspects analyzed in temperature below 25°C. Our results demonstrate that topically applied S. buxifolia gel presented anti-inflammatory effects, provided that it was maintained at a temperature below 25°C.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Edema/tratamento farmacológico
Géis
Rhamnaceae/química
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Anti-Inflamatórios/administração & dosagem
Óleo de Cróton/toxicidade
Estabilidade de Medicamentos
Edema/etiologia
Masculino
Camundongos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Gels); 8001-28-3 (Croton Oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE


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[PMID]:28027839
[Au] Autor:de Souza Figueiredo F; Celano R; de Sousa Silva D; das Neves Costa F; Hewitson P; Ignatova S; Piccinelli AL; Rastrelli L; Guimarães Leitão S; Guimarães Leitão G
[Ad] Endereço:Universidade Federal do Rio de Janeiro, Instituto de Pesquisas de Produtos Naturais, CCS, bloco H, Ilha do Fundão, 21941-590, RJ, Brazil.
[Ti] Título:Countercurrent chromatography separation of saponins by skeleton type from Ampelozizyphus amazonicus for off-line ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry analysis and characterisation.
[So] Source:J Chromatogr A;1481:92-100, 2017 Jan 20.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ampelozizyphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria, is a climbing shrub, native to the Amazonian region, with jujubogenin glycoside saponins as main compounds. The crude extract of this plant is too complex for any kind of structural identification, and HPLC separation was not sufficient to resolve this issue. Therefore, the aim of this work was to obtain saponin enriched fractions from the bark ethanol extract by countercurrent chromatography (CCC) for further isolation and identification/characterisation of the major saponins by HPLC and MS. The butanol extract was fractionated by CCC with hexane - ethyl acetate - butanol - ethanol - water (1:6:1:1:6; v/v) solvent system yielding 4 group fractions. The collected fractions were analysed by UHPLC-HRMS (ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry) and MS . Group 1 presented mainly oleane type saponins, and group 3 showed mainly jujubogenin glycosides, keto-dammarane type triterpene saponins and saponins with C skeleton. Thus, CCC separated saponins from the butanol-rich extract by skeleton type. A further purification of group 3 by CCC (ethyl acetate - ethanol - water (1:0.2:1; v/v)) and HPLC-RI was performed in order to obtain these unusual aglycones in pure form.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Distribuição Contracorrente/métodos
Espectrometria de Massas/métodos
Rhamnaceae/química
Saponinas/química
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Butanóis/química
Glicosídeos/química
Hexanos/química
Extratos Vegetais/química
Plantas Medicinais/química
Saponinas/análise
Solventes/química
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanols); 0 (Glycosides); 0 (Hexanes); 0 (Plant Extracts); 0 (Saponins); 0 (Solvents); 0 (Triterpenes); 0 (jujubogenin); 2DDG612ED8 (n-hexane); 545-22-2 (dammarane)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE


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[PMID]:27865442
[Au] Autor:Gossan DP; Alabdul Magid A; Yao-Kouassi PA; Ahibo Coffy A; Josse J; Gangloff SC; Morjani H; Voutquenne-Nazabadioko L
[Ad] Endereço:ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims, France; Laboratoire de Chimie Organique et de Substances Naturelles, Université Félix-Houphouët Boigny d'Abidjan-Cocody, 22 BP 582 Abidjan 22, Cote d'Ivoire.
[Ti] Título:Triterpene glycosides from the aerial parts of Gouania longipetala.
[So] Source:Phytochemistry;134:71-77, 2017 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Six previously undescribed triterpenoid saponins, gouaniaside I-VI, were isolated from the aerial parts of Gouania longipetala Hemsl. (Rhamnaceae), in addition to four known triterpenes. The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D- and 2D-NMR and HR-ESI-MS techniques. The inhibitory activity of isolated compounds against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated and jujuboside I exhibited moderate cytotoxicity, with IC values of 13.5 and 21.0 µM, respectively. Among the isolated triterpenes, alphitolic acid exhibited moderate antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (MICs 32, 64 and 128 µg/mL, respectively).
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Glicosídeos/isolamento & purificação
Componentes Aéreos da Planta/química
Rhamnaceae/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Enterococcus faecalis/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Glicosídeos/química
Glicosídeos/farmacologia
Células HL-60
Seres Humanos
Células K562
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Saponinas
Staphylococcus aureus/efeitos dos fármacos
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Glycosides); 0 (Saponins); 0 (Triterpenes); 0 (alphitolic acid); 0 (jujuboside I); 55466-04-1 (jujuboside A)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161121
[St] Status:MEDLINE


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[PMID]:27762456
[Au] Autor:Kim B; Woo MJ; Park CS; Lee SH; Kim JS; Kim B; An S; Kim SH
[Ad] Endereço:College of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea.
[Ti] Título:Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model.
[So] Source:Phytother Res;31(1):132-139, 2017 Jan.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hovenia dulcis Thunb. (HDT) was known to have anti-fatigue, anti-diabetes, neuroprotective, and hepatoprotective effects. In the present study, the anti-fatty liver mechanism of HDT was elucidated in oleic acid (OA)-treated Hep G2 cells and acute hyperlipidemia mouse model using Triton WR-1339. Here, HDT activated p-AMP-activated protein kinase (p-AMPK), proliferator activated receptor-α, carnitine palmitoyltransferase and also inhibited the expression of lipogenesis and cholesterol synthesis proteins, such as 3-hydroxy-3-methylglutaryl-CoA reductase, sterol regulatory element binding protein-1c, SREBP-2, and fatty acid synthase in OA-treated Hep G2 cells. Conversely, AMPK inhibitor compound C blocked the anti-fatty liver effect of HDT to induce AMPK phosphorylation and decrease 3-hydroxy-3-methylglutaryl-CoA reductase and lipid accumulation by oil red O staining in OA-treated Hep G2 cells. Additionally, HDT pretreatment protected against the increase of serum total cholesterol, triglyceride, low-density lipoprotein cholesterol and phospholipid in an acute hyperlipidemia mouse model with enhancement of glutathione reductase, glutathione peroxidase, superoxide dismutase, and catalase activities. Taken together, HDT inhibits OA-induced hepatic lipid accumulation via activation of AMPK and proliferator activated receptor-α/carnitine palmitoyltransferase signaling and enhancement of antioxidant activity as a potent candidate for nonalcoholic fatty liver disease and hyperlipidemia. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Hiperlipidemias/genética
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/patologia
Ácido Oleico/química
PPAR alfa/metabolismo
Rhamnaceae/química
Sementes/química
[Mh] Termos MeSH secundário: Animais
Carnitina O-Palmitoiltransferase/metabolismo
Modelos Animais de Doenças
Seres Humanos
Hiperlipidemias/metabolismo
Lipoproteínas LDL/metabolismo
Camundongos
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Hepatopatia Gordurosa não Alcoólica/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipoproteins, LDL); 0 (PPAR alpha); 2UMI9U37CP (Oleic Acid); EC 2.3.1.21 (Carnitine O-Palmitoyltransferase); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5741



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