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[PMID]:29413572
[Au] Autor:Li Y; Guo S; Hua T; Wang Y; Wei D; Zhao M; Su S; Duan JA
[Ad] Endereço:Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
[Ti] Título:Comparative pharmacokinetics of triterpenic acids in normal and immunosuppressed rats after oral administration of Jujubae Fructus extract by UPLC-MS/MS.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:13-21, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The fruit of Ziziphus jujuba (Jujubae Fructus) has been used as food and crude drug for thousands of years. Although several chemical and biological studies have revealed triterpenic acid as the main bioactive constituent of Jujubae Fructus responsible for immune-regulatory activity, only few pharmacokinetic studies have been conducted. To comprehend the kinetics of triterpenic acids and promote their curative application, a sensitive and efficient ultra-performance liquid chromatography coupled with mass spectrometry method (UPLC-MS/MS) was established. UPLC-MS/MS was applied for the simultaneous determination of ceanothic acid, epiceanothic acid, pomonic acid, alphitolic acid, maslinic acid, betulinic acid, and betulonic acid in normal and immunosuppressed rat plasma samples. After sample preparation, chromatographic separation was performed on an Acquity UPLC BEH C column (2.1 × 100 mm, 1.7 µm) with acetonitrile: methanol (1:1, v/v) and 0.5% ammonium acetate in water as mobile phase. The established method was validated and found to be specific, accurate, and precise for the seven triterpenic acids, and was successfully applied for the pharmacokinetic study of rat plasma samples. The results showed that the pharmacokinetic parameters (C , T , AUC , AUC and CLz/F) in the plasma samples of immunosuppressed rats were significantly different from those in normal rats, and might provide an insight for the clinical usage of triterpenic acids from Jujubae Fructus.
[Mh] Termos MeSH primário: Triterpenos/sangue
Triterpenos/farmacocinética
Ziziphus
[Mh] Termos MeSH secundário: Administração Oral
Animais
Estabilidade de Medicamentos
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/farmacocinética
Hospedeiro Imunocomprometido
Modelos Lineares
Masculino
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Triterpenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29251470
[Au] Autor:Bagdi DL; Bagri GK
[Ti] Título:Effect of saline irrigation water on gas exchange and proline metabolism in ber (Ziziphus).
[So] Source:J Environ Biol;37(5):873-9, 2016 09.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:An experiment was conducted in pots of 25 kg capacity to study the effect of saline irrigation (EC 0,5,10,15 and 20 dSm-1) prepared by mixing NaCl, NaSO4, CaCl and MgCl2 in 3:1 ratio of chloride and sulphate on gas exchange traits, membrane stability, chlorophyll stability index and osmolytic defense mechanism in Ziziphus rotundifolia and Ziziphus nummularia species of Indian jujube (Z.mauritiana). Result showed that net photosynthetic rate (PN), transpiration (e) and stomatal conductance were comparatively lower in Ziziphus nummularia, which further declined with increasing level of saline irrigation water. Chlorophyll stability and membrane stability also declined significantly in salt stress, with higher magnitude in Ziziphus nummularia. The activity of proline anabolic enzymes; Δ1-Pyrrolline-5-carboxylate reductase, Δ1-Pyrrolline-5-carboxylate synthetase and Ornithine-δ-aminotransferase were recorded higher in Ziziphus rotundifolia with decrease in proline dehydrogenase. The sodium content was observed higher in roots of Ziziphus rotundifolia and leaves of Ziziphus nummularia. Therefore, it is suggested that salt tolerance mechanism was more efficiently operative in Ziziphus rotundifolia owing to better management of physiological attributes, osmolytic defense mechanism and restricted translocation of sodium from root to leaves along with larger accumulation of potassium in its leaves.
[Mh] Termos MeSH primário: Irrigação Agrícola
Transpiração Vegetal/efeitos dos fármacos
Salinidade
Cloreto de Sódio/química
Água/química
Ziziphus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Clorofila/metabolismo
Fotossíntese
Prolina/metabolismo
Ziziphus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 1406-65-1 (Chlorophyll); 451W47IQ8X (Sodium Chloride); 9DLQ4CIU6V (Proline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:28976994
[Au] Autor:Guo M; Li S; Tian S; Wang B; Zhao X
[Ad] Endereço:College of Life Science, Luoyang Normal University, Luoyang, Henan, China.
[Ti] Título:Transcriptome analysis of genes involved in defense against alkaline stress in roots of wild jujube (Ziziphus acidojujuba).
[So] Source:PLoS One;12(10):e0185732, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wild jujube (Ziziphus acidojujuba Mill.) is highly tolerant to alkaline, saline and drought stress; however, no studies have performed transcriptome profiling to study the response of wild jujube to these and other abiotic stresses. In this study, we examined the tolerance of wild jujube to NaHCO3-NaOH solution and analyzed gene expression profiles in response to alkaline stress. Physiological experiments revealed that H2O2 content in leaves increased significantly and root activity decreased quickly during alkaline of pH 9.5 treatment. For transcriptome analysis, wild jujube plants grown hydroponically were treated with NaHCO3-NaOH solution for 0, 1, and 12 h and six transcriptomes from roots were built. In total, 32,758 genes were generated, and 3,604 differentially expressed genes (DEGs) were identified. After 1 h, 853 genes showed significantly different expression between control and treated plants; after 12 h, expression of 2,856 genes was significantly different. The expression pattern of nine genes was validated by quantitative real-time PCR. After gene annotation and gene ontology enrichment analysis, the genes encoding transcriptional factors, serine/threonine-protein kinases, heat shock proteins, cysteine-like kinases, calmodulin-like proteins, and reactive oxygen species (ROS) scavengers were found to be closely involved in alkaline stress response. These results will provide useful insights for elucidating the mechanisms underlying alkaline tolerance in wild jujube.
[Mh] Termos MeSH primário: Álcalis/farmacologia
Genes de Plantas
Raízes de Plantas/genética
Transcriptoma
Ziziphus/genética
[Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Alkalies)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185732


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[PMID]:28903731
[Au] Autor:Noritake SM; Liu J; Kanetake S; Levin CE; Tam C; Cheng LW; Land KM; Friedman M
[Ad] Endereço:Department of Biological Sciences, University of the Pacific, Stockton, CA, 95211, USA.
[Ti] Título:Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.
[So] Source:BMC Complement Altern Med;17(1):461, 2017 Sep 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Trichomonads are increasingly becoming resistant to conventional modes of treatment. It is of interest to test bioactive, natural compounds for efficacy against these pathogens. METHODS: Using a cell assay, black tea, green tea, grape, pomegranate, and jujube extracts, as well as whole dried jujube were tested against three trichomonads: Trichomonas vaginalis strain G3 (found in humans), Tritrichomonas foetus strain D1 (found in cattle), and Tritrichomonas foetus-like organism strain C1 (found in cats). The most effective of the test substances was subsequently tested against two metronidazole-resistant Trichomonas vaginalis strains, and on normal mucosal flora. RESULTS: Black tea extract inhibited all the tested trichomonads, but was most effective against the T. vaginalis organisms. Inhibition by black tea was correlated with the total and individual theaflavin content of the two tea extracts determined by HPLC. Metronidazole-resistant Trichomonas vaginalis strains were also inhibited by the black tea extract. The response of the organisms to the remaining preparations was variable and unique. We observed no effect of the black tea extract on common normal flora bacteria. CONCLUSIONS: The results suggest that the black tea, and to a lesser degree green tea, grape seed, and pomegranate extracts might present possible natural alternative therapeutic agents to treat Trichomonas vaginalis infections in humans and the related trichomonad infections in animals, without negatively affecting the normal flora.
[Mh] Termos MeSH primário: Doenças do Gato/microbiologia
Doenças dos Bovinos/microbiologia
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Tricomoníase/microbiologia
Tricomoníase/veterinária
Trichomonas vaginalis/efeitos dos fármacos
Tritrichomonas foetus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Camellia sinensis/química
Gatos
Bovinos
Seres Humanos
Viabilidade Microbiana/efeitos dos fármacos
Punicaceae/química
Trichomonas vaginalis/genética
Trichomonas vaginalis/crescimento & desenvolvimento
Trichomonas vaginalis/isolamento & purificação
Tritrichomonas foetus/genética
Tritrichomonas foetus/crescimento & desenvolvimento
Tritrichomonas foetus/isolamento & purificação
Vitis/química
Ziziphus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1967-x


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[PMID]:28832644
[Au] Autor:Mitsuhashi Y; Furusawa Y; Aradate T; Zhao QL; Moniruzzaman R; Kanamori M; Noguchi K; Kondo T
[Ad] Endereço:Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.
[Ti] Título:3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response.
[So] Source:PLoS One;12(8):e0183712, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:3-O-trans-p-coumaroyl-alphitolic acid (3OTPCA), a triterpenoid isolated from the plant Zizyphus jujuba (ZJ), is known to be cytotoxic to cancer cells; however, the molecular mechanism underlying 3OTPCA-induced cell death remains unknown. Here, we provide novel evidence that 3OTPCA induces apoptotic cell death in human leukemia cells. We found that 3OPTCA induces DNA fragmentation within 24 h after treatment in U937 cells, which was also observed in other leukemia cell lines, including Molt-4 and Jurkat cells. We then investigated other parameters involved in apoptosis, including phosphatidylserine externalization and caspase-3 cleavage in U937 cells treated with 3OTPCA. 3OTPCA caused significant DNA fragmentation, annexin-V binding, and caspase-3 cleavage, indicating that 3OTPCA exerts cytotoxicity through apoptosis induction. RNA-seq analysis revealed that the expression of transcripts associated with the unfolded protein response (UPR), such as spliced XBP-1 and CHOP, were up-regulated by 3OTPCA treatment. 3OTPCA-induced UPR activation may be due to endoplasmic reticulum (ER) stress because both 3OTPCA and thapsigargin, an endoplasmic Ca2+ transport ATPase inhibitor, increased intracellular calcium levels. 3OTPCA down-regulated the expression of Bcl-2, a target of CHOP, and led to the loss of the mitochondrial membrane, indicating that the intrinsic (mitochondrial) apoptotic pathway was triggered by 3OTPCA, likely through UPR activation. Furthermore, we found that 3OTPCA induced superoxide anion generation and, following p38 MAPK phosphorylation, caspase-8 cleavage without affecting Fas expression. It also induced subsequent Bid cleavage, which may enhance the apoptosis triggered by the intrinsic pathway. These findings reveal for the first time that 3OTPCA induces apoptotic cell death through the generation of reactive oxygen species and activation of UPR.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Leucemia de Células T/patologia
Espécies Reativas de Oxigênio/metabolismo
Triterpenos/farmacologia
Resposta a Proteínas não Dobradas
Ziziphus/química
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Cálcio/metabolismo
Ativação Enzimática
Seres Humanos
Células Jurkat
Leucemia de Células T/metabolismo
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Transcrição Genética/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-O-p-coumaroylalphitolic acid); 0 (Biomarkers); 0 (Reactive Oxygen Species); 0 (Triterpenes); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183712


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[PMID]:28610054
[Au] Autor:Jiao KL; Han PJ; Yang ML; Xiong RC; Wang YH; Bu WJ
[Ad] Endereço:Department of Plant Protection, College of Horticulture and Landscape, Tianjin Agricultural University, 22 Jinjing Road, Tianjin, 300384, China. jiaokelong@163.com.
[Ti] Título:A new species of gall midge (Diptera: Cecidomyiidae) attacking jujube, Ziziphus jujuba in China.
[So] Source:Zootaxa;4247(4):487-493, 2017 Mar 28.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Dasineura jujubifolia Jiao & Bu, sp. nov., a gall midge feeding on jujube, Ziziphus jujuba Miller (Rhamnaceae), a fruit tree cultivated extensively in large areas of China, is described and illustrated based on specimens collected from Alar (Xinjiang, China). The new gall midge species causes rolled leaf galls on Ziziphus jujuba in Northwestern China. Brief notes on the biology of the jujube gall midge are given.
[Mh] Termos MeSH primário: Dípteros
[Mh] Termos MeSH secundário: Animais
China
Chironomidae
Frutas
Ziziphus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4247.4.10


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[PMID]:28573232
[Au] Autor:Shahat AA; Mahmoud EA; Al-Mishari AA; Alsaid MS
[Ad] Endereço:Pharmacognosy Department, College of Pharmacy, King Saud University P.O. Box 2457, Riyadh 11451.
[Ti] Título:ANTIMICROBIAL ACTIVITIES OF SOME SAUDI ARABIAN HERBAL PLANTS.
[So] Source:Afr J Tradit Complement Altern Med;14(2):161-165, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several edible plants are used in Kingdom of Saudi Arabia since early time to control microbial infections. In the present study, twenty-four Saudi Arabian medicinal plants d according to traditionally used were select and investigated for the antimicrobial activities. MATERIALS AND METHODS: This study was designed at evaluating the antimicrobial activities of the methanol extracts of twenty-four species of sixteen plant families used in the traditional medicine by Saudi Arabian people for the treatment of numerous ailments of the microbial and non-microbial origin against four Gram-positive, four Gram-negative bacteria and four fungi and yeast using the agar well diffusion method. RESULTS: Of most of the plants tested were found to be active against two to eight organisms. Five plants were active against eight organisms. The data appeared that extracts of (SY-176), (SY- (SY-181), (SY-188), (SY-197) and (SY-198) have anti-microbial activity against the most of tested bacteria, fungi and yeast. Whereas (SY-, the extracts of (SY-175), (SY-187), and (SY-195) have poor action against the tested bacteria, fungi and yeast. CONCLUSION: The antimicrobial activity of plant extracts against bacteria was more effective than against fungi.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Fungos/efeitos dos fármacos
Magnoliopsida
Extratos Vegetais/farmacologia
Plantas Medicinais
[Mh] Termos MeSH secundário: Artemisia
Bactérias/crescimento & desenvolvimento
Echium
Fungos/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana
Resedaceae
Rumex
Arábia Saudita
Ziziphus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.17


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[PMID]:28513155
[Au] Autor:Jiao L; Li Y; Zhang Y; Liu J; Xie J; Zhang K; Zhou A
[Ti] Título:Degradation Kinetics of 6‴-p-Coumaroylspinosin and Identification of Its Metabolites by Rat Intestinal Flora.
[So] Source:J Agric Food Chem;65(22):4449-4455, 2017 Jun 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:6‴-p-Coumaroylspinosin (P-CS), a bioactive flavonoid, is typically extracted from Semen Ziziphi Spinosae (SZS). In this study, a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed to determine P-CS for investigating the degradation characteristics of P-CS incubated with rat feces. The results showed that P-CS degraded rapidly and the degradation speeds varied depending upon the P-CS concentrations (3, 15, and 30 µg/mL). The degradation of P-CS processes follow first-order kinetics. On the basis of the mass spectrometry (MS) spectrum mode of the product ions, two main metabolites of P-CS were identified. Swertisin was the main metabolite at 3 and 15 µg/mL, while spinosin was produced when the P-CS concentration was 30 µg/mL. Spinosin and swertisin could improve mRNA transcription levels of glutamate receptor K1, K2, and K3 (GluK1, GluK2, and GluK3) subunits in rat hippocampal neurons. In addition, they showed an obvious synergistic effect in this respect. Collectively, the results can be used to explain the metabolic and pharmacological mechanisms of P-CS.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/metabolismo
Flavonoides/química
Flavonoides/metabolismo
Microbioma Gastrointestinal
Intestinos/microbiologia
Ziziphus/metabolismo
[Mh] Termos MeSH secundário: Animais
Bactérias/química
Intestinos/metabolismo
Cinética
Masculino
Estrutura Molecular
Ratos
Ratos Sprague-Dawley
Sementes/química
Sementes/metabolismo
Ziziphus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 72063-39-9 (spinosin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01486


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[PMID]:28446160
[Au] Autor:Boakye-Gyasi E; Henneh IT; Abotsi WKM; Ameyaw EO; Woode E
[Ad] Endereço:Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. ebgyasi.pharm@knust.edu.gh.
[Ti] Título:Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.
[So] Source:BMC Complement Altern Med;17(1):231, 2017 Apr 26.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompounds that might become leads for the discovery of newer, effective and safer alternatives. Various parts of Ziziphus abyssinica have been used in folk medicine in several African countries as painkillers. However, there is no report on the possible anti-nociceptive effects of this plant especially the leaves, hence the need for this current study. METHODS: The possible anti-nociceptive activity of hydro-ethanolic leaf extract of Ziziphus abyssinica (EthE) was assessed in rodents using chemical (acetic acid, formalin and glutamate), thermal (tail-immersion test) and mechanical/inflammatory (carrageenan) models of nociception. RESULTS: EthE (30-300 mg/kg, p.o.) dose-dependently and significantly inhibited chemical-induced nociception with a maximum inhibition of 86.29 ± 2.27%, 76.34 ± 5.67%, 84.97 ± 5.35%, and 82.81 ± 5.97% respectively for acetic acid, formalin (phase 1), formalin (phase 2) and glutamate tests at its highest dose. EthE also dose-dependently and significantly increased reaction times in both tail-immersion and carrageenan-induced hypernociceptive tests. The activities of the extract in the various models were comparable with the effect of morphine hydrochloride and diclofenac sodium used as standard analgesic drugs. CONCLUSION: Oral administration of hydro-ethanolic leaf extract of Ziziphus abyssinica ameliorates nocifensive behaviours associated with chemical-, thermal- and mechanical/inflammatory - induced nociceptive pain.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Dor Nociceptiva/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Ziziphus
[Mh] Termos MeSH secundário: Ácido Acético
África
Analgésicos/uso terapêutico
Animais
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Comportamento Animal
Carragenina
Modelos Animais de Doenças
Feminino
Formaldeído
Ácido Glutâmico
Temperatura Alta
Inflamação/complicações
Masculino
Camundongos Endogâmicos ICR
Dor Nociceptiva/induzido quimicamente
Dor Nociceptiva/etiologia
Dor
Extratos Vegetais/farmacologia
Folhas de Planta
Ratos Sprague-Dawley
Tempo de Reação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 1HG84L3525 (Formaldehyde); 3KX376GY7L (Glutamic Acid); 9000-07-1 (Carrageenan); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1750-z


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[PMID]:28407906
[Au] Autor:Damiano S; Forino M; De A; Vitali LA; Lupidi G; Taglialatela-Scafati O
[Ad] Endereço:School of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy.
[Ti] Título:Antioxidant and antibiofilm activities of secondary metabolites from Ziziphus jujuba leaves used for infusion preparation.
[So] Source:Food Chem;230:24-29, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ziziphus jujuba Mill., jujube, leaf infusions are popular bedtime beverages as they improve sleep by soothing the nerves. With the aim of providing further insights into the polyphenol content of jujube leaf infusion and their antioxidant activities, a 2,2-diphenyl-1-picrylhydrazyl (DPPH)-guided purification of the aqueous extract of Z. jujuba Mill. leaves was conducted. Three major antioxidant polyphenols (i.e. quercitrin, catechin and gallocatechin) of the leaves were identified. In addition, a significant antibiofilm bioactivity against Streptococcus mutans, a causative agent of human dental caries, was detected for the aqueous leaf extract and its bio-guided separation resulted in the identification of the lupane triterpenoid alphitolic acid as the main antibiofilm metabolite. The results herein presented further promote the consumption of jujube leaf infusion as a healthy antioxidant bedtime beverage, and associate it to an unreported anti-caries activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Flavonoides/análise
Folhas de Planta/química
Streptococcus mutans/efeitos dos fármacos
Triterpenos/farmacologia
Ziziphus/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Cárie Dentária/microbiologia
Seres Humanos
Extratos Vegetais/química
Folhas de Planta/metabolismo
Triterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Triterpenes); 464-99-3 (lupane)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE



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