Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.859.937.500.033 [Categoria DeCS] Referências encontradas : 62 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28458099 [Au] Autor: Seo UM; Nguyen DH; Zhao BT; Min BS; Woo MH [Ad] Endereço: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea. [Ti] Título: Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects. [So] Source: Carbohydr Res;445:75-79, 2017 Jun 05. [Is] ISSN: 1873-426X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-ß-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-ß-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 µM, except compounds 1 and 4 were inactive. [Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo Agrimonia/química Flavanonas/química Glucosídeos/química Glucosídeos/farmacologia Componentes Aéreos da Planta/química [Mh] Termos MeSH secundário: Inibidores da Colinesterase/química Inibidores da Colinesterase/farmacologia Concentração Inibidora 50 [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cholinesterase Inhibitors); 0 (Flavanones); 0 (Glucosides); EC 3.1.1.7 (Acetylcholinesterase) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180125 [Lr] Data última revisão: 180125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 28870184 [Au] Autor: Jang HH; Nam SY; Kim MJ; Kim JB; Choi JS; Kim HR; Lee YM [Ad] Endereço: Functional Food & Nutrition Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea. [Ti] Título: Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response. [So] Source: BMC Complement Altern Med;17(1):442, 2017 Sep 05. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, the effects of aqueous extracts from A. pilosa on insulin-resistant rats have not yet been examined. We investigated the effects of aqueous extract from A. pilosa on impaired glucose metabolism induced by a high-fat diet in rats. METHODS: Male Sprague-Dawley rats were assigned to the following groups: normal-fat diet (NF, n = 9); high-fat diet (HF, n = 9); high-fat diet with 0.1% A. pilosa aqueous extract (HFA, n = 10). Experimental diets were administered for 16 weeks. At the end of the treatment, liver and fat tissues were isolated, and serum was collected for biochemical analysis. RESULTS: The HF group rats had a significantly higher liver weight than the NF group rats did, and increased hepatic lipid accumulation (p < 0.05); however, supplementation with A. pilosa decreased liver weight. Blood glucose levels in the HFA group were lower than levels measured in the HF group 30, 60, and 120 min after glucose administration (p < 0.05). In addition, dietary A. pilosa supplementation decreased tumor necrosis factor α and interleukin 6 levels, while increasing serum adiponectin concentrations (p < 0.05 vs. the HF group). These effects were accompanied by reduced hepatic and adipose tissue expression of inflammation-related genes such as Tnf and Il1b (p < 0.05). CONCLUSIONS: Our findings indicate that A. pilosa aqueous extract can ameliorate insulin resistance in high-fat diet-fed rats by decreasing the inflammatory response. [Mh] Termos MeSH primário: Agrimonia/química Intolerância à Glucose/tratamento farmacológico Extratos Vegetais/administração & dosagem [Mh] Termos MeSH secundário: Animais Glicemia/metabolismo Dieta Hiperlipídica/efeitos adversos Intolerância à Glucose/etiologia Intolerância à Glucose/imunologia Intolerância à Glucose/metabolismo Seres Humanos Insulina/metabolismo Interleucina-6/genética Interleucina-6/imunologia Fígado/metabolismo Masculino Obesidade/tratamento farmacológico Obesidade/etiologia Obesidade/imunologia Obesidade/metabolismo Ratos Ratos Sprague-Dawley Fator de Necrose Tumoral alfa/genética Fator de Necrose Tumoral alfa/imunologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Blood Glucose); 0 (Insulin); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170906 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-1949-z

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[PMID]: 28499190 [Au] Autor: Nguyen DH; Seo UM; Zhao BT; Le DD; Seong SH; Choi JS; Min BS; Woo MH [Ad] Endereço: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province 290000, Viet Nam. [Ti] Título: Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activities. [So] Source: Bioorg Chem;72:293-300, 2017 Jun. [Is] ISSN: 1090-2120 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A new ellagitannin, agritannin (1), a new flavone glycoside, agriflavone (2), and another flavone glycoside with spectroscopic data reported for the first time, kaempferol-3-O-[(S)-3-hydroxy-3-methylglutaryl (1→6)]-ß-d-glucoside (3), along with 16 known compounds were isolated from the aerial parts of Agrimonia pilosa Ledeb. These compounds were evaluated for PTP1B inhibitory activity. Among them, compounds 9 and 18 displayed potential inhibitory activity against PTP1B with IC values of 7.14±1.75 and 7.73±0.24µM, respectively. In addition, compound 1 showed significant inhibitory effect with an IC value of 17.03±0.09µM. Furthermore, these compounds were tested in AChE inhibitory assays. Most of them were found to have moderate inhibitory effects, with IC values ranging from 60.20±1.09 to 92.85±1.12µM. Except compounds 3, 8, and 18 were inactive. [Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo Agrimonia/química Inibidores Enzimáticos/farmacologia Flavonoides/farmacologia Taninos Hidrolisáveis/farmacologia Extratos Vegetais/farmacologia Proteínas Tirosina Fosfatases/antagonistas & inibidores [Mh] Termos MeSH secundário: Butirilcolinesterase/metabolismo Anidrase Carbônica I/antagonistas & inibidores Anidrase Carbônica I/metabolismo Anidrase Carbônica II/antagonistas & inibidores Anidrase Carbônica II/metabolismo Relação Dose-Resposta a Droga Inibidores Enzimáticos/química Inibidores Enzimáticos/isolamento & purificação Flavonoides/química Flavonoides/isolamento & purificação Seres Humanos Taninos Hidrolisáveis/química Taninos Hidrolisáveis/isolamento & purificação Estrutura Molecular Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Proteínas Tirosina Fosfatases/metabolismo Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Enzyme Inhibitors); 0 (Flavonoids); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (ellagitannin); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); EC 3.1.3.48 (Protein Tyrosine Phosphatases); EC 4.2.1.- (Carbonic Anhydrase I); EC 4.2.1.- (Carbonic Anhydrase II) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170513 [St] Status: MEDLINE

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[PMID]: 28245624 [Au] Autor: Zhu L; Chen J; Tan J; Liu X; Wang B [Ad] Endereço: Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China. zhuliancai75@126.com. [Ti] Título: Flavonoids from Agrimonia pilosa Ledeb: Free Radical Scavenging and DNA Oxidative Damage Protection Activities and Analysis of Bioactivity-Structure Relationship Based on Molecular and Electronic Structures. [So] Source: Molecules;22(3), 2017 Feb 26. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: To clarify the substantial basis of the excellent antioxidant capacity of Ledeb. Fourteen flavonoids were isolated and identified from Ledeb, seven of which have notable DPPH radical scavenging activities, i.e., catechin, luteolin, quercetin, quercitrin, hyperoside, rutin, luteolin-7- -ß-glucoside with IC values of 5.06, 7.29, 4.36, 7.12, 6.34, 6.36 and 8.12 µM, respectively. The DNA nicking assay showed that five flavonoids from Ledeb-taxifolin, catechin, hyperoside, quercitrin and rutin-have good protective activity against DNA oxidative damage. Further, we analyzed the bioactivity-structure relationship of these 14 flavonoids by applying quantum theory. According to their O-H bond dissociation enthalpy (BDE), C ring's spin density and stable molecular structure, the relationship between their structures and radical scavenging capacities was evaluated and clarified. We found that among flavonoid aglycones from Ledeb, the O-H BDE of quercetin is lowest with the values of 69.02 and the O-H BDE of apigenin is highest with the values of 79.77. It is interesting that the O-H BDE value of isovitexin (78.55) with glycoside at C-6 position is lower than that of its aglycone (79.77) and vitexin (99.20) with glycoside at C-8 position. Further analysis indicated that the glycosidation of flavonoids at C-6 in the A-ring makes a more uniform distribution of spin density and improves the stability of free radicals leading to the increase in antioxidant capacity. Flavonoids with good antioxidant capacity might contribute to the pharmacological effects of Ledeb. [Mh] Termos MeSH primário: Agrimonia/química Dano ao DNA/efeitos dos fármacos Flavonoides/análise Flavonoides/farmacologia Estresse Oxidativo/efeitos dos fármacos [Mh] Termos MeSH secundário: Catequina/química Catequina/farmacologia Flavonoides/química Estrutura Molecular Extratos Vegetais/química Extratos Vegetais/farmacologia Quercetina/análogos & derivados Quercetina/química Quercetina/farmacologia Rutina/química Rutina/farmacologia Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flavonoids); 0 (Plant Extracts); 2Y8906LC5P (quercitrin); 5G06TVY3R7 (Rutin); 8O1CR18L82 (hyperoside); 8R1V1STN48 (Catechin); 9IKM0I5T1E (Quercetin); 9SOB9E3987 (taxifolin) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170508 [Lr] Data última revisão: 170508 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170302 [St] Status: MEDLINE

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[PMID]: 28237881 [Au] Autor: Tang L; Fu L; Lu C; Hou X; Shan W; Zhan Z [Ad] Endereço: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China. [Ti] Título: New cytotoxic phloroglucinol derivatives from Agrimonia pilosa. [So] Source: Fitoterapia;118:69-72, 2017 Apr. [Is] ISSN: 1873-6971 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Three new phloroglucinol derivatives, namely agripinol A-C (1-3), were isolated from Agrimonia pilosa Ledeb, along with two known ones (4-5). Their structures were characterized by spectroscopic methods, including MS and NMR spectroscopic techniques. The absolute configurations of the new compounds were unambiguously established by single crystal X-ray diffraction analyses. In the cytotoxicity assay, all compounds exhibited more potent cytotoxic activities against HCT-116, MDA-MB-231 and PC-3, as compared with the positive control fluorouracil. [Mh] Termos MeSH primário: Agrimonia/química Antineoplásicos Fitogênicos/química Floroglucinol/química [Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação Linhagem Celular Tumoral Seres Humanos Estrutura Molecular Floroglucinol/isolamento & purificação Difração de Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); DHD7FFG6YS (Phloroglucinol) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170425 [Lr] Data última revisão: 170425 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170227 [St] Status: MEDLINE

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[PMID]: 28208627 [Au] Autor: Kim SB; Hwang SH; Suh HW; Lim SS [Ad] Endereço: Department of Food Science and Nutrition, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do 24252, Korea. jwsbcb0187@naver.com. [Ti] Título: Phytochemical Analysis of Agrimonia pilosa Ledeb, Its Antioxidant Activity and Aldose Reductase Inhibitory Potential. [So] Source: Int J Mol Sci;18(2), 2017 Feb 10. [Is] ISSN: 1422-0067 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: The aim of this study was to determine aldose reductase (AR) inhibitory activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of compounds from Ledeb (AP). We isolated agrimoniin (AM), four flavonoid glucosides and two flavonoid glucuronides from the -butanol fraction of AP 50% methanol extract. In addition to isolated compounds, the AR-inhibitory activity and the DPPH free radical scavenging activity of catechin, 5-flavonoids, and 4-flavonoid glucosides (known components of AP) against rat lens AR (RLAR) and DPPH assay were measured. AM showed IC values of 1.6 and 13.0 µM against RLAR and DPPH scavenging activity, respectively. Additionally, AM, luteolin-7- -glucuronide (LGN), quercitrin (QU), luteolin (LT) and afzelin (AZ) showed high inhibitory activity against AR and were first observed to decrease sorbitol accumulation in the rat lens under high-sorbitol conditions ex vivo with inhibitory values of 47.6%, 91.8%, 76.9%, 91.8% and 93.2%, respectively. Inhibition of recombinant human AR by AM, LGN and AZ exhibited a noncompetitive inhibition pattern. Based on our results, AP and its constituents may play partial roles in RLAR and oxidative radical inhibition. Our results suggest that AM, LGN, QU, LT and AZ may potentially be used as natural drugs for treating diabetic complications. [Mh] Termos MeSH primário: Agrimonia/química Aldeído Redutase/antagonistas & inibidores Antioxidantes/química Antioxidantes/farmacologia Compostos Fitoquímicos/química Extratos Vegetais/química Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão Ativação Enzimática Flavonoides/química Depuradores de Radicais Livres/química Depuradores de Radicais Livres/farmacologia Cinética Estrutura Molecular [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phytochemicals); 0 (Plant Extracts); EC 1.1.1.21 (Aldehyde Reductase) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170420 [Lr] Data última revisão: 170420 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170218 [St] Status: MEDLINE

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[PMID]: 26842885 [Au] Autor: Park S; Kang S; Kim DS; Moon BR [Ad] Endereço: a Department of Food and Nutrition , Obesity/Diabetes Center, Hoseo University , 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795 , South Korea. [Ti] Título: Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in ß-amyloid-infused rats. [So] Source: Nutr Neurosci;20(2):77-88, 2017 Feb. [Is] ISSN: 1476-8305 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: The water extracts of Cinnamomum cassia Blume bark (CCB; Lauraceae), Lonicera japonica Thunb. flower (LJT; Caprifoliaceae), and Agrimonia pilosa Ledeb. leaves (APL; Rosaceae) prevented amyloid-ß (25-35)-induced cell death in PC12 cells in our preliminary study. We evaluated whether long-term oral consumption of CCB, LJT, and APL improves cognitive dysfunction and glucose homeostasis in rats with experimentally induced AD-type dementia. METHODS: Male rats received hippocampal CA1 infusions of amyloid-ß (25-35, AD) or amyloid-ß (35-25, non-plaque forming, normal-controls, Non-AD-CON), at a rate of 3.6 nmol/day for 14 days. AD rats were divided into four groups receiving either 2% lyophilized water extracts of CCB, LJT, or APL or 2% dextrin (AD-CON) in high-fat diets (43% energy as fat). RESULTS: Hippocampal amyloid-ß deposition, tau phosphorylation, and expressions of tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS) (neruoinflammation markers) were increased, and insulin signaling decreased in AD-CON. CCB, LJT, and APL all prevented hippocampal amyloid-ß accumulation and enhanced hippocampal insulin signaling. CCB, LJT, and APL decreased TNF-α and iNOS in the hippocampus and especially APL exhibited the greatest decrease. AD-CON exhibited cognitive dysfunction in passive avoidance and water maze tests, whereas CCB, LJT, and APL protected against cognitive dysfunction, and APL was most effective and was similar to Non-AD-CON. AD-CON had less fat oxidation as an energy fuel, but it was reversed by CCB, LJT, and especially APL. APL-treated rats had less visceral fat than AD-CON rats. AD-CON rats exhibited impaired insulin sensitivity and increased insulin secretion during oral glucose tolerance test compared with Non-AD-CON, but CCB and APL prevented the impairment. DISCUSSION: These results supported that APL, LJT, and CCB effectively prevent the cognitive dysfunction and the impairment of energy and glucose homeostasis induced by amyloid-ß deposition by reducing neuroinflammation and enhancing insulin signaling. APL exhibited the greatest effectiveness for improving cognitive function. [Mh] Termos MeSH primário: Agrimonia/química Doença de Alzheimer/dietoterapia Cinnamomum aromaticum/química Modelos Animais de Doenças Lonicera/química Nootrópicos/uso terapêutico Extratos Vegetais/uso terapêutico [Mh] Termos MeSH secundário: Doença de Alzheimer/metabolismo Doença de Alzheimer/patologia Doença de Alzheimer/fisiopatologia Animais Comportamento Animal Biomarcadores/metabolismo Disfunção Cognitiva/etiologia Disfunção Cognitiva/prevenção & controle Metabolismo Energético Flores/química Intolerância à Glucose/etiologia Intolerância à Glucose/prevenção & controle Hipocampo/imunologia Hipocampo/metabolismo Hipocampo/patologia Hipoglicemiantes/isolamento & purificação Hipoglicemiantes/uso terapêutico Resistência à Insulina Masculino Neurônios/imunologia Neurônios/metabolismo Neurônios/patologia Nootrópicos/isolamento & purificação Casca de Planta/química Extratos Vegetais/isolamento & purificação Folhas de Planta/química Ratos Sprague-Dawley [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Hypoglycemic Agents); 0 (Nootropic Agents); 0 (Plant Extracts) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170313 [Lr] Data última revisão: 170313 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160205 [St] Status: MEDLINE [do] DOI: 10.1080/1028415X.2015.1135572

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[PMID]: 28487904 [Au] Autor: Lee KH; Rhee KH [Ad] Endereço: CKD Research Institute, Chong Kun Dang Pharm., Yongin, 449-797, Republic of Korea. [Ti] Título: ANTI-NOCICEPTIVE EFFECT OF AGRIMONIA EUPATORIA EXTRACT ON A CISPLATIN-INDUCED NEUROPATHIC MODEL. [So] Source: Afr J Tradit Complement Altern Med;13(5):139-144, 2016. [Is] ISSN: 2505-0044 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: BACKGROUND: Natural products including are considered an incomparable source of molecular diversity that has led to the medicines, especially for pain treatment. To investigate the antinociception of , we examined its activity in a rat model of cisplatin neuropathy. MATERIALS AND METHODS: Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin twice a week at a dose of 2 mg/kg (cumulative dose, 20 mg/kg) for 4 weeks. Before each injection, 2 ml of sterile saline solution was given subcutaneously to prevent renal damage via hyperhydration. The mice were treated with gabapetin as a positive control drug with a 100mg/kg intraperitoneal injection. extract of 200mg/kg was solved in saline and then treated by oral administration. RESULTS: The mice treated with showed lower withdrawal duration in the pin-prick and plantar tests, and a higher withdrawal threshold in the paw-withdrawal threshold test as compared to control animals in a cisplatin-induced neuropathic model. In the case of cold-allodynia, treatment increased paw-withdrawal duration in a chemical test. showed a more outstanding effect than gabapentin in all used tests for preventing cisplatin-induced nerve injury for 4 weeks. CONCLUSIONS: Our results suggest that extract showed an antinociceptive effect in the pin-prick test, plantar test, and paw-withdrawal threshold test using a cisplatin-induced neuropathic rat model. [Mh] Termos MeSH primário: Agrimonia/química Analgésicos/farmacologia Neuralgia/tratamento farmacológico Fitoterapia/métodos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Aminas/farmacologia Animais Cisplatino Ácidos Cicloexanocarboxílicos/farmacologia Pé/fisiopatologia Masculino Neuralgia/induzido quimicamente Limiar da Dor/efeitos dos fármacos Ratos Ratos Sprague-Dawley Ácido gama-Aminobutírico/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amines); 0 (Analgesics); 0 (Cyclohexanecarboxylic Acids); 0 (Plant Extracts); 56-12-2 (gamma-Aminobutyric Acid); 6CW7F3G59X (gabapentin); Q20Q21Q62J (Cisplatin) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170812 [Lr] Data última revisão: 170812 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170511 [St] Status: MEDLINE [do] DOI: 10.21010/ajtcam.v13i5.18

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[PMID]: 27588326 [Au] Autor: Kim HW; Park J; Kang KB; Kim TB; Oh WK; Kim J; Sung SH [Ad] Endereço: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea. [Ti] Título: Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa. [So] Source: J Nat Prod;79(9):2376-83, 2016 Sep 23. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells. [Mh] Termos MeSH primário: Agrimonia/química Catequina/isolamento & purificação Medicamentos de Ervas Chinesas/isolamento & purificação Isocumarinas/isolamento & purificação Floroglucinol/análogos & derivados [Mh] Termos MeSH secundário: Animais Biflavonoides Catequina/química Catequina/farmacologia Medicamentos de Ervas Chinesas/química Medicamentos de Ervas Chinesas/farmacologia Glicosídeos/química Glicosídeos/isolamento & purificação Glicosídeos/farmacologia Isocumarinas/química Isocumarinas/farmacologia Lipopolissacarídeos/farmacologia Macrófagos/efeitos dos fármacos Camundongos Estrutura Molecular Óxido Nítrico/biossíntese Ressonância Magnética Nuclear Biomolecular Floroglucinol/química Floroglucinol/isolamento & purificação Proantocianidinas República da Coreia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Isocoumarins); 0 (Lipopolysaccharides); 0 (Proanthocyanidins); 31C4KY9ESH (Nitric Oxide); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); DHD7FFG6YS (Phloroglucinol) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170627 [Lr] Data última revisão: 170627 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160903 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.6b00566

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[PMID]: 27313126 [Au] Autor: Liu WJ; Hou XQ; Chen H; Liang JY; Sun JB [Ad] Endereço: a Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , China. [Ti] Título: Chemical constituents from Agrimonia pilosa Ledeb. and their chemotaxonomic significance. [So] Source: Nat Prod Res;30(21):2495-9, 2016 Nov. [Is] ISSN: 1478-6427 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Phytochemical investigation of the ethanol extract from the whole plant of Agrimonia pilosa led to the isolation of 31 compounds, including 16 flavonoids (1-16), 5 triterpenes (17-21), 1 isocoumarin (22), 5 phenolic acids (23-27), 1 ceramide (28), 2 agrimols (29-30) and 1 fatty acid (31). Their structures were determined by various spectroscopic analyses. Compounds 5, 7 and 20 were firstly isolated from the genus Agrimonia, and compounds 6, 10-11, 15, 26, 28 and 31 were isolated from the family Rosaceae for the first time. Moreover, the chemotaxonomic significance of these compounds was summarised. [Mh] Termos MeSH primário: Agrimonia/química [Mh] Termos MeSH secundário: Agrimonia/classificação Flavonoides/análise Flavonoides/química Extratos Vegetais/análise Triterpenos/análise Triterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flavonoids); 0 (Plant Extracts); 0 (Triterpenes) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160618 [St] Status: MEDLINE [do] DOI: 10.1080/14786419.2016.1198351

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