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Pesquisa : B01.650.940.800.575.912.250.859.937.500.055 [Categoria DeCS]
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  1 / 21 MEDLINE  
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[PMID]:28502116
[Au] Autor:Seker Karatoprak G; Ilgün S; Kosar M
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri, 38039, Turkey.
[Ti] Título:Phenolic Composition, Anti-Inflammatory, Antioxidant, and Antimicrobial Activities of Alchemilla mollis (Buser) Rothm.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The current study was designed to evaluate the antioxidant, anti-inflammatory and antimicrobial activities of Alchemilla mollis (Buser) Rothm. (Rosaceae) aerial parts extracts. Chemical composition was analyzed by spectrophotometric and chromatographic (HPLC) techniques. The antioxidant properties assessed included DPPH and ABTS radical scavenging, ß-carotene-linoleic acid co-oxidation assay. Antimicrobial activity was evaluated with disc diffusion and micro dilution method. In order to evaluate toxicity of the extracts, with the sulforhodamine B colorimetric assay L929 cell line (mouse fibroblast) was used. The anti-inflammatory activities of the potent antioxidant extracts (methanol, 70% methanol, and water extracts) were determined by measuring the inhibitory effects on NO production and pro-inflammatory cytokine TNF-α levels in lipopolysaccharide stimulated RAW 264.7 cells. 70% methanol and water extracts which were found to be rich in phenolic compounds (184.79 and 172.60 mg GAE/g extract) showed higher antioxidant activity. Luteolin-7-O-glucoside was the main compound in the extracts. Ethyl acetate and 70% methanol extracts showed higher antibacterial activity against Staphylococcus aureus and Salmonella enteritidis with MIC value of 125 µg/ml. 70% methanol extract potentially inhibited the NO and TNF-α production (18.43 µm and 1556.22 pg/ml, respectively, 6 h).
[Mh] Termos MeSH primário: Alchemilla/química
Anti-Infecciosos/química
Anti-Inflamatórios/química
Antioxidantes/química
Fenóis/química
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Ácido Linoleico/química
Camundongos
Óxido Nítrico/imunologia
Oxirredução/efeitos dos fármacos
Fenóis/isolamento & purificação
Fenóis/farmacologia
Células RAW 264.7
Fator de Necrose Tumoral alfa/imunologia
beta Caroteno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Phenols); 0 (Tumor Necrosis Factor-alpha); 01YAE03M7J (beta Carotene); 31C4KY9ESH (Nitric Oxide); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700150


  2 / 21 MEDLINE  
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[PMID]:27978496
[Au] Autor:Ozbek H; Acikara OB; Keskin I; Kirmizi NI; Ozbilgin S; Oz BE; Kurtul E; Ozrenk BC; Tekin M; Saltan G
[Ad] Endereço:Istanbul Medipol University, Faculty of Medicine, Department of Pharmacology, Istanbul, Turkey.
[Ti] Título:Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis.
[So] Source:Biomed Pharmacother;86:172-176, 2017 Feb.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100mg/kg and 200mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties.
[Mh] Termos MeSH primário: Alchemilla
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Fígado/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/patologia
Avaliação Pré-Clínica de Medicamentos/métodos
Feminino
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/farmacologia
Fígado/patologia
Masculino
Camundongos
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Raízes de Plantas
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/farmacologia
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE


  3 / 21 MEDLINE  
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[PMID]:26520565
[Au] Autor:Gehrke B; Kandziora M; Pirie MD
[Ad] Endereço:Institut für Spezielle Botanik und Botanischer Garten, Johannes Gutenberg Universität, Mainz, Germany and gehrke@uni-mainz.de.
[Ti] Título:The evolution of dwarf shrubs in alpine environments: a case study of Alchemilla in Africa.
[So] Source:Ann Bot;117(1):121-31, 2016 Jan.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Alpine and arctic environments worldwide, including high mountains, are dominated by short-stature woody plants (dwarf shrubs). This conspicuous life form asserts considerable influence on local environmental conditions above the treeline, creating its own microhabitat. This study reconstructs the evolution of dwarf shrubs in Alchemilla in the African tropical alpine environment, where they represent one of the largest clades and are among the most common and abundant plants. METHODS: Different phylogenetic inference methods were used with plastid and nuclear DNA sequence markers, molecular dating (BEAST and RelTime), analyses of diversification rate shifts (MEDUSA and BAMM) and ancestral character and area reconstructions (Mesquite). KEY RESULTS: It is inferred that African Alchemilla species originated following long-distance dispersal to tropical East Africa, but that the evolution of dwarf shrubs occurred in Ethiopia and in tropical East Africa independently. Establishing a timeframe is challenging given inconsistencies in age estimates, but it seems likely that they originated in the Pleistocene, or at the earliest in the late Miocene. The adaptation to alpine-like environments in the form of dwarf shrubs has apparently not led to enhanced diversification rates. Ancestral reconstructions indicate reversals in Alchemilla from plants with a woody base to entirely herbaceous forms, a transition that is rarely reported in angiosperms. CONCLUSIONS: Alchemilla is a clear example of in situ tropical alpine speciation. The dwarf shrub life form typical of African Alchemilla has evolved twice independently, further indicating its selective advantage in these harsh environments. However, it has not influenced diversification, which, although recent, was not rapid.
[Mh] Termos MeSH primário: Alchemilla/fisiologia
Evolução Biológica
Ecossistema
[Mh] Termos MeSH secundário: África
Variação Genética
Geografia
Filogenia
Análise de Sequência de DNA
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151102
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcv159


  4 / 21 MEDLINE  
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[PMID]:26669107
[Au] Autor:Afshar FH; Maggi F; Ferrari S; Peron G; Dall'Acqua S
[Ti] Título:Secondary Metabolites of Alchemilla persica Growing in Iran (East Azarbaijan).
[So] Source:Nat Prod Commun;10(10):1705-8, 2015 Oct.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigations of Alchemilla persica Rothm. growing in Iran were performed taking into account both the volatile and polar constituents. The hydrodistilled essential oil was analysed by GC-MS that revealed the presence of alkanes (27.8%), diterpenoids (19.6%) and sesquiterpene hydrocarbons (17.1%) as the major constituents, while tannins and flavonol glycosides were identified as the most abundant constituents of the methanol extract by HPLC-MS. A. persica can be a valuable source of ellagitannins and polyphenols.
[Mh] Termos MeSH primário: Alchemilla/metabolismo
[Mh] Termos MeSH secundário: Alchemilla/química
Cromatografia Líquida de Alta Pressão
Cromatografia Gasosa-Espectrometria de Massas
Irã (Geográfico)
Óleos Voláteis/química
Componentes Aéreos da Planta/química
Óleos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151216
[Lr] Data última revisão:
151216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151217
[St] Status:MEDLINE


  5 / 21 MEDLINE  
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[PMID]:26434119
[Au] Autor:Krivokuca M; Niketic M; Milenkovic M; Golic N; Masia C; Scaltrito MM; Sisto F; Kundakovic T
[Ti] Título:Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae).
[So] Source:Nat Prod Commun;10(8):1369-71, 2015 Aug.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study evaluated the anti-Helicobacterpylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Fröhner), A. fissa Günther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-ß-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 µg/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 µg/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 µg/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 µg/mL), while the second identified compound, quercetin-3-O-ß-D-glucoside, was also very active in concentration of 2-16 µg/mL.
[Mh] Termos MeSH primário: Alchemilla/química
Antibacterianos/farmacologia
Helicobacter pylori/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Infecções por Helicobacter
Helicobacter pylori/fisiologia
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:151005
[Lr] Data última revisão:
151005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151006
[St] Status:MEDLINE


  6 / 21 MEDLINE  
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[PMID]:25700659
[Au] Autor:Küpeli Akkol E; Demirel MA; Bahadir Acikara O; Süntar I; Ergene B; Ilhan M; Ozbilgin S; Saltan G; Keles H; Tekin M
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey, akkolesra@gmail.com.
[Ti] Título:Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model.
[So] Source:Arch Gynecol Obstet;292(3):619-28, 2015 Sep.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats. METHODS: Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups. The groups were orally treated with the methanol:water (80:20) extracts of aerial parts and roots of A. mollis and A. persica. Buserelin acetate (20 mg) was used as the reference drug. The phytochemical contents of the most active extracts were determined by high performance liquid chromatography. RESULTS: The cystic formation was determined to be significantly decreased with the aerial part extract of A. mollis. A reduction in the endometrioma was also determined for the aerial part extract of A. persica group. However, significant reduction on the levels of cytokine were recorded for the A. mollis aerial part extract group. Therefore, the phytochemical contents of the aerial part extracts of A. mollis. and A. persica were analyzed. CONCLUSION: The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.
[Mh] Termos MeSH primário: Alchemilla/química
Endometriose/tratamento farmacológico
Fitoterapia
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Endometriose/metabolismo
Feminino
Seres Humanos
Masculino
Componentes Aéreos da Planta/química
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150810
[Lr] Data última revisão:
150810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150222
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-015-3665-6


  7 / 21 MEDLINE  
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[PMID]:25451083
[Au] Autor:Juranovic Cindric I; Zeiner M; Pozgaj M; Silic T; Stingeder G
[Ad] Endereço:Laboratory of Analytical Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
[Ti] Título:Elemental characterisation of the medical plant Alchemilla velebitica.
[So] Source:J Trace Elem Med Biol;31:274-8, 2015.
[Is] ISSN:1878-3252
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Alchemilla, commonly called "lady's mantle", is a genus of herbaceous perennial plants belonging to the family Rosaceae. The species Alchemilla velebitica is found only in Southern Europe, like in the Croatian National Park Northern Velebit. Its benefits, such as a astringent and emmenagogue activity as well as wound healing are correlated to the organic compounds found in the plant, but also certain trace elements are known to reduce skin lesions, such as zinc, selenium, copper, manganese, silicon and lithium. Thus the objective of the present study was the elemental characterization of leaves, blossoms and roots of A. velebitica. After acidic microwave assisted digestion the concentrations of selected essential and trace elements were determined by inductively coupled plasma--atomic emission spectrometry and inductively coupled plasma--mass spectrometry. Other minor elements, such as Al, B, Cu, Fe, Mn, Sr and Zn are also found in leaves, blossoms and roots with contents in µg/kg range. The preparation of decoctions and the extraction yields of the elements of interest are calculated.
[Mh] Termos MeSH primário: Alchemilla/química
Plantas Medicinais/química
Chás Medicinais/análise
Oligoelementos/análise
[Mh] Termos MeSH secundário: Cobre/análise
Croácia
Manganês/análise
Espectrometria de Massas/métodos
Micro-Ondas
Extratos Vegetais/análise
Extratos Vegetais/química
Selênio/análise
Zinco/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Trace Elements); 42Z2K6ZL8P (Manganese); 789U1901C5 (Copper); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150525
[Lr] Data última revisão:
150525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  8 / 21 MEDLINE  
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[PMID]:24938755
[Au] Autor:Takir S; Sezgi B; Süzgeç-Selçuk S; Eroglu-Özkan E; Beukelman KJ; Mat A; Uydes-Dogan BS
[Ad] Endereço:a Department of Pharmacology , Faculty of Pharmacy, Istanbul University , Beyazit, 34116 Istanbul , Turkey.
[Ti] Título:Endothelium-dependent vasorelaxant effect of Alchemilla vulgaris methanol extract: a comparison with the aqueous extract in rat aorta.
[So] Source:Nat Prod Res;28(23):2182-5, 2014.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate the vascular effects of methanol extract (ME) and aqueous extract (AE) of Alchemilla vulgaris (Rosaceaea). Increasing concentrations of the ME (0.01-10 mg/mL) produced relaxations in noradrenaline (NA: 10⁻6 M) and K⁺ (40 mM) precontracted aortas while contractions were obtained with the AE (0.01-10 mg/mL). Responses to the ME were inhibited in the presence of putative inhibitors of endothelial vasodilators or after removal of the endothelium. Pretreatment of aortic rings with the ME (10 mg/mL, 20 min) reduced the maximal contractions to NA and K⁺, whereas an enhanced contractility was observed with the AE (10 mg/mL, 20 min). Total flavonoid content was higher in the ME than in the AE. Quercetin was determined particularly high in the ME while gallic acid was high in the AE. Our results indicated that the ME of A. vulgaris displays favourable vascular effects via endothelium-dependent mechanisms.
[Mh] Termos MeSH primário: Aorta/efeitos dos fármacos
Endotélio/metabolismo
Flavonoides/farmacologia
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Alchemilla
Animais
Flavonoides/análise
Flavonoides/química
Metanol
Ratos
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Vasodilator Agents); 059QF0KO0R (Water); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140929
[Lr] Data última revisão:
140929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140619
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.926352


  9 / 21 MEDLINE  
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[PMID]:24270383
[Au] Autor:Makau JN; Watanabe K; Kobayashi N
[Ad] Endereço:Laboratory of Molecular Biology of Infectious Agents, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
[Ti] Título:Anti-influenza activity of Alchemilla mollis extract: possible virucidal activity against influenza virus particles.
[So] Source:Drug Discov Ther;7(5):189-95, 2013 Oct.
[Is] ISSN:1881-7831
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Influenza virus infection is a major public health problem that leads to significant morbidity and mortality. The emergence of resistance to the currently available anti-influenza agents has necessitated the development of new drugs with novel targets. Studying known ethno-medicinal plants is a promising approach for the discovery of new antiviral compounds. Alchemilla mollis is used in traditional medicine in Europe for different indications, including minimizing the symptoms of a sore throat. In this study, we found that A. mollis extract has anti-influenza activity, and investigated the mechanism underlying its inhibition of influenza virus replication. Plaque assays demonstrated that treatment of cells with A. mollis extract prior to infection did not inhibit influenza virus infection. However, plaque formation was markedly reduced when infected cells were overlaid with an agarose gel containing A. mollis extract. In addition, exposure of the virus to A. mollis extract prior to infection and treatment of cells during virus infection significantly suppressed plaque formation. Influenza virus-induced hemagglutination of chicken red blood cells was inhibited by A. mollis extract treatment. The inhibitory effect was observed against influenza A virus subtypes H1N1, H3N2, and H5N2. These findings suggest that A. mollis extract has virucidal or neutralizing activity against influenza virus particles. Furthermore, inhibitory effect of zanamivir synergistically increased after combination with A. mollis extract. Our results suggest that A. mollis extract has the potential to be developed as an antiinfluenza agent.
[Mh] Termos MeSH primário: Alchemilla/química
Antivirais/farmacologia
Extratos Vegetais/farmacologia
Replicação Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antivirais/administração & dosagem
Galinhas
Cães
Sinergismo Farmacológico
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Testes de Inibição da Hemaglutinação
Seres Humanos
Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos
Vírus da Influenza A Subtipo H3N2/efeitos dos fármacos
Vírus da Influenza A Subtipo H5N2/efeitos dos fármacos
Influenza Humana/tratamento farmacológico
Células Madin Darby de Rim Canino
Medicina Tradicional
Orthomyxoviridae/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Zanamivir/administração & dosagem
Zanamivir/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); L6O3XI777I (Zanamivir)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:131125
[Lr] Data última revisão:
131125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131126
[St] Status:MEDLINE


  10 / 21 MEDLINE  
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[PMID]:23687690
[Au] Autor:Duckstein SM; Lotter EM; Meyer U; Lindequist U; Stintzing FC
[Ad] Endereço:WALA Heilmittel GmbH, Department of Research & Development, Dorfstrasse 1, D-73087 Bad Boll/Eckwälden, Germany.
[Ti] Título:Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) Rothm. at different dates of harvest.
[So] Source:Z Naturforsch C;68(1-2):529-40, 2013 Jan-Feb.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Acetone/water extracts from the leaves, including stalks, of Alchemilla vulgaris L. and A. mollis (Buser) Rothm. were investigated for their phenolic composition by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 24 and 27 compounds were detected for A. vulgaris and A. mollis, respectively. Pedunculagin and agrimoniin, as described in earlier reports for A. vulgaris, as well as other monomeric and oligomeric ellagitannins such as sanguiin H-10, castalagin/vescalagin, and galloyl-bis-hexahydroxydiphenoyl (HHDP) hexose constituted the major phenolic fraction of both plant species. Also, gallic and chlorogenic acids were found in both extracts. Interestingly, catechin and a procyanidin trimer were detected only in A. mollis. The flavonoid fraction comprised quercetin glucuronide as major compound in addition to several other quercetin glycosides. Most interestingly, a tentatively identified kaempferol glucuronide and a methylated quercetin glucuronide were exclusively found in A. mollis. Finally, the overall phenolic fingerprints of both Alchemilla species, harvested in May and August, i.e. at the beginning and the end of the flowering period, were compared. A general accumulation of phenolic constituents was observed later in the year, especially with regard to the ellagitannins.
[Mh] Termos MeSH primário: Alchemilla/química
Fenóis/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Líquida
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:CORRECTED AND REPUBLISHED ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:130827
[Lr] Data última revisão:
130827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130522
[St] Status:MEDLINE



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