Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.222 [Categoria DeCS]
Referências encontradas : 169 [refinar]
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[PMID]:28615062
[Au] Autor:Hadjipieri M; Georgiadou EC; Marin A; Diaz-Mula HM; Goulas V; Fotopoulos V; Tomás-Barberán FA; Manganaris GA
[Ad] Endereço:Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3603, Lemesos, Cyprus.
[Ti] Título:Metabolic and transcriptional elucidation of the carotenoid biosynthesis pathway in peel and flesh tissue of loquat fruit during on-tree development.
[So] Source:BMC Plant Biol;17(1):102, 2017 Jun 14.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Carotenoids are the main colouring substances found in orange-fleshed loquat fruits. The aim of this study was to unravel the carotenoid biosynthetic pathway of loquat fruit (cv. 'Obusa') in peel and flesh tissue during distinct on-tree developmental stages through a targeted analytical and molecular approach. RESULTS: Substantial changes regarding colour parameters, both between peel and flesh and among the different developmental stages, were monitored, concomitant with a significant increment in carotenoid content. Key genes and individual compounds that are implicated in the carotenoid biosynthetic pathway were further dissected with the employment of molecular (RT-qPCR) and advanced analytical techniques (LC-MS). Results revealed significant differences in carotenoid composition between peel and flesh. Thirty-two carotenoids were found in the peel, while only eighteen carotenoids were identified in the flesh. Trans-lutein and trans-ß-carotene were the major carotenoids in the peel; the content of the former decreased with the progress of ripening, while the latter registered a 7.2-fold increase. However, carotenoid profiling of loquat flesh indicated trans-ß-cryptoxanthin, followed by trans-ß-carotene and 5,8-epoxy-ß-carotene to be the most predominant carotenoids. High amounts of trans-ß-carotene in both tissues were supported by significant induction in a chromoplast-specific lycopene ß-cyclase (CYCB) transcript levels. PSY1, ZDS, CYCB and BCH were up-regulated and CRTISO, LCYE, ECH and VDE were down-regulated in most of the developmental stages compared with the immature stage in both peel and flesh tissue. Overall, differential regulation of expression levels with the progress of on-tree fruit development was more evident in the middle and downstream genes of carotenoid biosynthetic pathway. CONCLUSIONS: Carotenoid composition is greatly affected during on-tree loquat development with striking differences between peel and flesh tissue. A link between gene up- or down-regulation during the developmental stages of the loquat fruit, and how their expression affects carotenoid content per tissue (peel or flesh) was established.
[Mh] Termos MeSH primário: Carotenoides/biossíntese
Eriobotrya/genética
[Mh] Termos MeSH secundário: Vias Biossintéticas
Clorofila/análise
Cromatografia Líquida
Frutas/genética
Regulação da Expressão Gênica de Plantas
Espectrometria de Massas
Transcrição Genética
Transcriptoma
Árvores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-65-1 (Chlorophyll); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1186/s12870-017-1041-3


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[PMID]:28490095
[Au] Autor:Song H; Wang X; Hu W; Yang X; Diao E; Shen T; Qiang Q
[Ad] Endereço:Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huai'an 223300, Jiangsu, China; Huaian Key Laboratory of Food Components and Functional Food
[Ti] Título:A cold-induced phytosulfokine peptide is related to the improvement of loquat fruit chilling tolerance.
[So] Source:Food Chem;232:434-442, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel peptidomics approach was used to discover cold-induced peptides in loquat fruit. Twenty unique peptides derived from 18 proproteins were identified, and they were involved in sugar signalling, protein metabolism and stress response. The quantitative analysis revealed 7 peptides with more than 2-fold upregulation, especially a 4.96-fold increase detected in the phytosulfokine (PSK) peptide. To further evaluate effects of PSK1 on fruit chilling tolerance, weight loss, firmness and internal browning were investigated in PSK1-treated loquat fruit at 0°C. By contrast, these chilling injury symptoms were effectively reduced by PSK1. PSK1 markedly delayed decreases of ATP content and energy charge. The PSK1-treated fruit exhibited significantly lower activities of cell-wall degrading enzymes and transcripts of genes related to lignin synthesis. Our results demonstrated that PSK1 improves chilling tolerance of loquat fruit by maintaining high energy status and cell integrity. Peptidomics analysis provides a promising tool to discover some key peptides.
[Mh] Termos MeSH primário: Eriobotrya
Frutas
Hormônios Peptídicos
Proteínas de Plantas
[Mh] Termos MeSH secundário: Carboidratos
Parede Celular
Temperatura Baixa
Peptídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (PSK-alpha protein, plant); 0 (Peptide Hormones); 0 (Peptides); 0 (Plant Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28411320
[Au] Autor:Lin L; Liao M; Lv X; Liang D; Xia H; Wang J; Wang X
[Ad] Endereço:Institute of Pomology and Olericulture, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
[Ti] Título:Addition of straw from hyperaccumulator plants to cadmium-contaminated soil increases cadmium uptake by loquat seedlings.
[So] Source:Environ Monit Assess;189(5):217, 2017 May.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The straw from three different cadmium (Cd) hyperaccumulators (Galinsoga parviflora, Youngia erythrocarpa, and Solanum photeinocarpum) was added to Cd-contaminated soil, and its effects on plant growth and Cd accumulation in loquat seedlings were evaluated. Straw from each of G. parviflora, Y. erythrocarpa, and S. photeinocarpum was added to Cd-contaminated soil before planting seedlings of two varieties of loquat (Dawuxing and Chuanzao). Addition of straw from G. parviflora and S. photeinocarpum increased the root and shoot biomasses of both loquat varieties, compared with that in the control. Addition of straw also increased Cd uptake by loquat seedlings. The treatments could be ranked, from highest Cd contents in roots and shoots of loquat seedlings to lowest, as follows: S. photeinocarpum straw > Y. erythrocarpa straw > G. parviflora straw > control. All three types of hyperaccumulator straw increased the amount of Cd extracted by shoots of two loquat seedlings, with the maximum effect in the S. photeinocarpum straw treatment. Addition of hyperaccumulator straw also resulted in increased soil invertase, urease, and catalase activities to varying degrees. Among the three types of hyperaccumulator straw, S. photeinocarpum straw was the most effective to increase Cd accumulation in loquat seedlings. Therefore, this material has the potential to increase the phytoremediation capacity of loquat seedlings in Cd-contaminated orchards.
[Mh] Termos MeSH primário: Cádmio/análise
Monitoramento Ambiental/métodos
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Biomassa
Eriobotrya
Raízes de Plantas/química
Plântulas/química
Solanum/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5941-3


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[PMID]:28124052
[Au] Autor:Chen B; Long P; Sun Y; Meng Q; Liu X; Cui H; Lv Q; Zhang L
[Ad] Endereço:State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China. zhli2091@sina.com.
[Ti] Título:The chemical profiling of loquat leaf extract by HPLC-DAD-ESI-MS and its effects on hyperlipidemia and hyperglycemia in rats induced by a high-fat and fructose diet.
[So] Source:Food Funct;8(2):687-694, 2017 Feb 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the inhibitory effects of loquat leaf extract (LLE) on pancreatic α-amylase and α-glucosidase, and the preventative effects of LLE on hyperlipidemia and hyperglycemia in rats induced by a high fat and fructose diet have been evaluated. The LLE was chemically described using a high performance liquid chromatography-diode array detector coupled with a mass spectrometer (HPLC-DAD-MS/MS). 20 compounds including phenolic acids, flavonoids and triterpene acids were tentatively identified with authentic compounds or by referring to published articles and accessible databases (e.g. MassBank, METLIN). Enzyme activity measurements showed that the IC values of the LLE on α-amylase and α-glucosidase were 11.34 ± 1.04 mg mL and 50.77 ± 1.04 µg mL , respectively. The calculated Michaelis-Menten constants indicated that the LLE is an effective inhibitor against α-glucosidase in a mixed-model competitive mode. The fluorescence data revealed that the LLE binds with α-amylase and α-glucosidase. The animal experiment results indicated that the LLE significantly decreased the levels of fasting blood glucose, and hepatic and serum triglycerides.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Eriobotrya/química
Frutose/efeitos adversos
Hiperglicemia/tratamento farmacológico
Hiperlipidemias/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/química
Frutose/metabolismo
Seres Humanos
Hiperglicemia/enzimologia
Hiperglicemia/metabolismo
Hiperlipidemias/enzimologia
Hiperlipidemias/metabolismo
Cinética
Masculino
Extratos Vegetais/química
Folhas de Planta/química
Ratos
Espectrometria de Massas em Tandem
alfa-Amilases/antagonistas & inibidores
alfa-Amilases/química
alfa-Amilases/metabolismo
alfa-Glucosidases/química
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); 30237-26-4 (Fructose); EC 3.2.1.1 (alpha-Amylases); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01578f


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[PMID]:28088087
[Au] Autor:Alos E; Martinez-Fuentes A; Reig C; Mesejo C; Rodrigo MJ; Agustí M; Zacarías L
[Ad] Endereço:Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Av. Agustín Escardino 7, 46980 Paterna, Valencia, Spain. Electronic address: enri.alosros@kuleuven.be.
[Ti] Título:Ethylene biosynthesis and perception during ripening of loquat fruit (Eriobotrya japonica Lindl.).
[So] Source:J Plant Physiol;210:64-71, 2017 Mar.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In order to gain insights into the controversial ripening behavior of loquat fruits, in the present study we have analyzed the expression of three genes related to ethylene biosynthesis (ACS1, ACO1 and ACO2), two ethylene receptors (ERS1a and ERS1b), one signal transduction component (CTR1) and one transcription factor (EIL1) in peel and pulp of loquat fruit during natural ripening and also in fruits treated with ethylene (10µLL ) and 1-MCP (10µLL ), an ethylene action inhibitor. In fruits attached to or detached from the tree, a slight increase in ethylene production was detected at the yellow stage, but the respiration rate declined progressively during ripening. Accumulation of transcripts of ethylene biosynthetic genes did not correlate with changes in ethylene production, since the maximum accumulation of ACS1 and ACO1 mRNA was detected in fully coloured fruits. Expression of ethylene receptor and signaling genes followed a different pattern in peel and pulp tissues. After fruit detachment and incubation at 20°C for up to 6days, ACS1 mRNA slightly increased, ACO1 experienced a substantial increment and ACO2 declined. In the peel, these changes were advanced by exogenous ethylene and partially inhibited by 1-MCP. In the pulp, 1-MCP repressed most of the changes in the expression of biosynthetic genes, while ethylene had almost no effects. Expression of ethylene perception and signaling genes was barely affected by ethylene or 1-MCP. Collectively, a differential transcriptional regulation of ethylene biosynthetic genes operates in peel and pulp, and support the notion of non-climacteric ripening in loquat fruits. Ethylene action, however, appears to be required to sustain or maintain the expression of specific genes.
[Mh] Termos MeSH primário: Eriobotrya/metabolismo
Etilenos/biossíntese
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Eriobotrya/genética
Eriobotrya/crescimento & desenvolvimento
Frutas/crescimento & desenvolvimento
Frutas/metabolismo
Regulação da Expressão Gênica de Plantas
Proteínas de Plantas/genética
Receptores de Superfície Celular/genética
Receptores de Superfície Celular/metabolismo
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 0 (Plant Proteins); 0 (Receptors, Cell Surface); 0 (ethylene receptors, plant); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


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[PMID]:27929430
[Au] Autor:Liu Y; Zhang W; Xu C; Li X
[Ad] Endereço:Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zhejiang University, Zijingang Campus, Hangzhou 310058, China. yilongliu@zju.edu.cn.
[Ti] Título:Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review.
[So] Source:Int J Mol Sci;17(12), 2016 Dec 06.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Loquat ( Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and different extracts exhibit bioactivity capable of counteracting inflammation, diabetes, cancer, bacterial infection, aging, pain, allergy and other health issues. Bioactive compounds such as phenolics and terpenoids have been isolated and characterized to provide a better understanding of the chemical mechanisms underlying the biological activities of loquat extracts. As the identification of compounds progresses, studies investigating the in vivo metabolism, bioavailability, and structure-activity relationships, as well as potential toxicity of loquat extracts in animal or cell models are receiving more attention. In addition, genetic studies and breeding of loquat germplasms for high contents of health-benefiting compounds may provide new insight for the loquat industry and research. This review is focused on the main medicinal properties reported and the possible pharmaceutically active compounds identified in different loquat extracts.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Eriobotrya/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27827928
[Au] Autor:Song H; Zhao X; Hu W; Wang X; Shen T; Yang L
[Ad] Endereço:Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, College of Life Science, Huaiyin Normal University, Huai'an 223300, Jiangsu, China. loquathw@163.com.
[Ti] Título:Comparative Transcriptional Analysis of Loquat Fruit Identifies Major Signal Networks Involved in Fruit Development and Ripening Process.
[So] Source:Int J Mol Sci;17(11), 2016 Nov 04.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Loquat ( Lindl.) is an important non-climacteric fruit and rich in essential nutrients such as minerals and carotenoids. During fruit development and ripening, thousands of the differentially expressed genes (DEGs) from various metabolic pathways cause a series of physiological and biochemical changes. To better understand the underlying mechanism of fruit development, the Solexa/Illumina RNA-seq high-throughput sequencing was used to evaluate the global changes of gene transcription levels. More than 51,610,234 high quality reads from ten runs of fruit development were sequenced and assembled into 48,838 unigenes. Among 3256 DEGs, 2304 unigenes could be annotated to the Gene Ontology database. These DEGs were distributed into 119 pathways described in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. A large number of DEGs were involved in carbohydrate metabolism, hormone signaling, and cell-wall degradation. The real-time reverse transcription (qRT)-PCR analyses revealed that several genes related to cell expansion, auxin signaling and ethylene response were differentially expressed during fruit development. Other members of transcription factor families were also identified. There were 952 DEGs considered as novel genes with no annotation in any databases. These unigenes will serve as an invaluable genetic resource for loquat molecular breeding and postharvest storage.
[Mh] Termos MeSH primário: Eriobotrya/genética
Frutas/genética
Regulação da Expressão Gênica de Plantas
Proteínas de Plantas/genética
Transcriptoma
[Mh] Termos MeSH secundário: Carotenoides/biossíntese
Eriobotrya/crescimento & desenvolvimento
Eriobotrya/metabolismo
Etilenos/metabolismo
Frutas/crescimento & desenvolvimento
Frutas/metabolismo
Perfilação da Expressão Gênica
Regulação da Expressão Gênica no Desenvolvimento
Ontologia Genética
Sequenciamento de Nucleotídeos em Larga Escala
Ácidos Indolacéticos/metabolismo
Redes e Vias Metabólicas/genética
Anotação de Sequência Molecular
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 0 (Indoleacetic Acids); 0 (Plant Proteins); 36-88-4 (Carotenoids); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27473288
[Au] Autor:Koeduka T; Kajiyama M; Furuta T; Suzuki H; Tsuge T; Matsui K
[Ad] Endereço:Department of Biological Chemistry, Faculty of Agriculture and Division of Agricultural Sciences, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yamaguchi 753-8515, Japan. Electronic address: takaori@yamaguchi-u.ac.jp.
[Ti] Título:Characterization of an O-methyltransferase specific to guaiacol-type benzenoids from the flowers of loquat (Eriobotrya japonica).
[So] Source:J Biosci Bioeng;122(6):679-684, 2016 Dec.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Volatile benzenoids, including methyl p-methoxybenzoate, p-anisaldehyde, and p-anisalcohol, are responsible for the sweet and characteristic fragrance of loquat (Eriobotrya japonica, Rosaceae) flowers. Although the full pathway of volatile benzenoid synthesis has yet to be elucidated, their chemical structures suggest that O-methyltransferases are present in loquat and function in the methylation of the para-OH groups. In the present study, we used RNA-sequencing to identify four loquat genes (EjOMT1, EjOMT2, EjOMT3, and EjOMT4) that encode O-methyltransferases. We found that EjOMT1 was highly expressed in floral tissues, with an expression pattern that coincided with changes in intracellular volatile benzenoids during flower development. Recombinant EjOMT1 protein expressed in Escherichia coli showed the highest activity towards guaiacol with a K value of 35 µM. Furthermore, the protein also showed lesser activities towards guaiacol-type benzenoids including eugenol, isoeugenol, vanillin, and ferulic acid, in addition to much weaker activities towards catechol and p-hydroxybenzenoid derivatives. However, no activity was shown towards phenylpropenes without m-methoxy substitution, t-anol and chavicol. Taken together, our findings indicate that EjOMT1 has a broad substrate specificity towards compounds with both para-OH and meta-OCH groups, unlike previously characterized O-methyltransferases for volatile benzenoid/phenylpropanoid biosynthesis.
[Mh] Termos MeSH primário: Eriobotrya/genética
Guaiacol/metabolismo
Metiltransferases/genética
Metiltransferases/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Benzaldeídos/metabolismo
Clonagem Molecular
Eriobotrya/enzimologia
Eugenol/análogos & derivados
Eugenol/metabolismo
Flores/química
Flores/genética
Flores/metabolismo
Filogenia
Alinhamento de Sequência
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 3T8H1794QW (Eugenol); 5M0MWY797U (isoeugenol); 6JKA7MAH9C (Guaiacol); 9PA5V6656V (4-anisaldehyde); EC 2.1.1.- (Methyltransferases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE


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[PMID]:27392960
[Au] Autor:Gentile C; Reig C; Corona O; Todaro A; Mazzaglia A; Perrone A; Gianguzzi G; Agusti M; Farina V
[Ad] Endereço:Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze, 90128, Palermo, Italy.
[Ti] Título:Pomological Traits, Sensory Profile and Nutraceutical Properties of Nine Cultivars of Loquat (Eriobotrya japonica Lindl.) Fruits Grown in Mediterranean Area.
[So] Source:Plant Foods Hum Nutr;71(3):330-8, 2016 Sep.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper the diversity of fruit quality within nine loquat cultivars, including five international affirmed cultivars (Algerie, Golden Nugget, Peluche, Bueno, El Buenet) and four local cultivars (Sanfilippara, Nespolone di Trabia, BRT20 and Claudia), were investigated in order to discriminate the variation in pomological characteristics, sensory profile, and antioxidant properties. Finally, to evaluate potential bioactivity, antiproliferative activity of hydrophilic extracts from loquat fruits was assessed, at dietary relevant concentrations, against three human epithelial cell lines. Even though the international cultivars confirmed an appropriate level of commercial qualities in association to high levels in antioxidant compounds, the local cultivars revealed the best performances in a wide range of chemical-physical and sensory characteristics. Concerning bioactivity, our results indicate that hydrophilic extracts from all tested cultivars showed concentration-dependent antiproliferative activity with a significant variability of effects between different cell lines and between different cultivars. HeLa cells, the most sensitive and hydrophilic extracts from Peluche, showed the highest inhibitory effect followed by Nespolone di Trabia and Claudia. The results of this trial provide useful information on the pomological traits and the not yet known specific nutritional and functional properties of loquat fruits. Our data, besides helping to promote specific local cultivars, could serve to establish a database that will permit to improve the utilization of specific genetic resources in breeding programs.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Eriobotrya/química
Frutas/química
Paladar
[Mh] Termos MeSH secundário: Antioxidantes/análise
Antioxidantes/farmacologia
Ácido Ascórbico/análise
Ácido Ascórbico/farmacologia
Células CACO-2
Carotenoides/análise
Carotenoides/farmacologia
Proliferação Celular/efeitos dos fármacos
Fenômenos Químicos
Eriobotrya/classificação
Qualidade dos Alimentos
Células HeLa
Seres Humanos
Células MCF-7
Região do Mediterrâneo
Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/análise
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 36-88-4 (Carotenoids); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0564-3


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[PMID]:27323036
[Au] Autor:Gao YS; Yuan Y; Song G; Lin SQ
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong, China.
[Ti] Título:Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo.
[So] Source:Genet Mol Res;15(2), 2016 May 13.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) and oleanolic acid (OA) from wild loquat were previously found capable of suppressing the proliferation of A549 cells in vitro. In the current study, nude mice were used to determine the inhibitory effect of UA and OA on tumor formation in vivo. The results demonstrate that UA and OA reduced the proliferation of A549 cells in nude mice, and increased the expression of Bid while decreasing the protein levels of MMP-2, Ki-67, and CD34. In this study, we identified potential antitumor activity in a wild loquat extract containing UA and OA, which demonstrates that traditional Chinese medicine may have a role in treating certain types of cancer.
[Mh] Termos MeSH primário: Adenocarcinoma Bronquíolo-Alveolar/tratamento farmacológico
Eriobotrya/química
Ácido Oleanólico/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Células A549
Adenocarcinoma Bronquíolo-Alveolar/patologia
Animais
Antineoplásicos Fitogênicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Feminino
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Folhas de Planta/química
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Triterpenes); 6SMK8R7TGJ (Oleanolic Acid); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15028642



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