Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.244 [Categoria DeCS]
Referências encontradas : 32 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 4 ir para página            

  1 / 32 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27871982
[Au] Autor:Katanic J; Matic S; Pferschy-Wenzig EM; Kretschmer N; Boroja T; Mihailovic V; Stankovic V; Stankovic N; Mladenovic M; Stanic S; Mihailovic M; Bauer R
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia. Electronic address: jkatanic@kg.ac.rs.
[Ti] Título:Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
[So] Source:Food Chem Toxicol;99:86-102, 2017 Jan.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC > 50 µg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Cisplatino/toxicidade
Filipendula/química
Nefropatias/prevenção & controle
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/toxicidade
Sobrevivência Celular/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Cromatografia Líquida/métodos
Dano ao DNA/efeitos dos fármacos
Rim/metabolismo
Nefropatias/induzido quimicamente
Fígado/metabolismo
Espectrometria de Massas/métodos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


  2 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27827272
[Au] Autor:Bespalov VG; Alexandrov VA; Semenov AL; Kovan'ko EG; Ivanov SD; Vysochina GI; Kostikova VA; Baranenko DA
[Ad] Endereço:a N. N. Petrov Research Institute of Oncology of Ministry of Health of Russian Federation , St. Petersburg , Russia.
[Ti] Título:The inhibitory effect of meadowsweet (Filipendula ulmaria) on radiation-induced carcinogenesis in rats.
[So] Source:Int J Radiat Biol;93(4):394-401, 2017 Apr.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats. MATERIALS AND METHODS: The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. Adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy in animal experiments. One group of irradiated rats served as control while the other group, starting from the 10th day after irradiation and until the end of the experiment, was given meadowsweet as a decoction of the flowers instead of drinking water. The average daily intake of meadowsweet (dry raw material) was 1 g/kg body weight. Rats were observed for 16 months. RESULTS: The analyzed meadowsweet extracts showed a sufficiently high content of flavonoids and tannins. In irradiated rats after 16 months the overall incidence of tumors was 79.6% (in 82 of 103 rats), the incidence of malignant tumors was 43.7% and the overall tumor multiplicity was 1.48. Most tumors were localized in the mammary gland - 57.3%. In rats that received meadowsweet, the incidence of all malignant tumors and overall multiplicity of tumors were significantly decreased by 1.5 and 1.3 times, respectively. The greatest reduction of many parameters has been identified for breast tumors: the overall incidence was decreased by 1.5 (p = 0.0174) and the overall multiplicity and multiplicity of malignant tumors - by 1.6 (p = 0.0002) and 2.2 (p = 0.0383) times, respectively. CONCLUSIONS: Meadowsweet preparation showed inhibiting activity on radiation carcinogenesis.
[Mh] Termos MeSH primário: Filipendula/química
Neoplasias Induzidas por Radiação/patologia
Neoplasias Induzidas por Radiação/prevenção & controle
Extratos Vegetais/administração & dosagem
Protetores contra Radiação/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Carcinogênese/efeitos dos fármacos
Carcinogênese/efeitos da radiação
Relação Dose-Resposta a Droga
Relação Dose-Resposta à Radiação
Feminino
Flores/química
Neoplasias Induzidas por Radiação/etiologia
Dose de Radiação
Ratos
Taxa de Sobrevida
Resultado do Tratamento
Irradiação Corporal Total/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Radiation-Protective Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE
[do] DOI:10.1080/09553002.2016.1257834


  3 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28333678
[Au] Autor:Lupatini NR; Danopoulos P; Swikidisa R; Alves PV
[Ad] Endereço:Juiz de Fora (SUPREMA), Juiz de Fora, MG, Brazil.
[Ti] Título:Evaluation of the Antibacterial Activity of Green Propolis Extract and Meadowsweet Extract Against Staphylococcus aureus Bacteria: Importance in Would Care Compounding Preparations.
[So] Source:Int J Pharm Compd;20(4):333-337, 2016 Jul-Aug.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of natural products in compounded wound care formulas is an exciting avenue to pursue for compounding pharmacists since these natural products may contain compounds that promote healing on their own. The use of these natural extracts as an alternative therapy for wound care may also provide several benefits, such as decreased inflammation, infection, side effects, and treatment costs. Thus far, several studies have demonstrated antimicrobial activity for various natural product extracts, including green propolis and meadowsweet. The antimicrobial properties of these extracts make them particularly interesting for wound care because the healing process is significantly delayed by bacterial infection and colonization at the site of injury. Therefore, to further investigate the antimicrobial properties of green propolis and meadowsweet extracts, we performed minimum inhibitory concentration and minimum bactericidal concentration assays against Staphylococcus aureus, a microorganism known to cause wound infections. The antimicrobial activity of green propolis and meadowsweet extracts was tested in vitro against a standard strain of Staphylococcus aureus in brain heart infusion broth and Mueller-Hinton agar plates. Green propolis extract demonstrated antimicrobial activity against Staphylococcus aureus with a minimum inhibitory concentration of 1.25 mg/mL and a minimum bactericidal concentration of 1.25 mg/mL. In contrast, meadowsweet extract failed to inhibit Staphylococcus aureus growth at the highest concentration tested (30 mg/mL). Green propolis was more effective than meadowsweet extract at inhibiting the growth of Staphylococcus aureus, suggesting that the addition of green propolis extract in wound care formulas might be more beneficial for the treatment of wounds. Therefore, we propose that green propolis extract is a promising natural product for wound care formulations.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Filipendula/química
Extratos Vegetais/farmacologia
Própole/farmacologia
Infecções Cutâneas Estafilocócicas/prevenção & controle
Staphylococcus aureus/efeitos dos fármacos
Infecção da Ferida Cirúrgica/prevenção & controle
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Relação Dose-Resposta a Droga
Composição de Medicamentos
Testes de Sensibilidade Microbiana
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Própole/química
Infecções Cutâneas Estafilocócicas/microbiologia
Infecção da Ferida Cirúrgica/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 9009-62-5 (Propolis)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


  4 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28035976
[Au] Autor:Olennikov DN; Kashchenko NI; Chirikova NK
[Ad] Endereço:Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh'yanovoy Street, 6, Ulan-Ude 670047, Russia. olennikovdn@mail.ru.
[Ti] Título:Meadowsweet Teas as New Functional Beverages: Comparative Analysis of Nutrients, Phytochemicals and Biological Effects of Four Filipendula Species.
[So] Source:Molecules;22(1), 2016 Dec 26.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In recent years, the increased popularity of functional beverages such as herbal teas and decoctions has led to the search for new sources of raw materials that provide appropriate taste and functionality to consumers. The objective of this study was to investigate the nutritional, phytochemical profiles and bioactivities of possible functional beverages produced from and its alternative substitutes ( , , ). The investigated decoctions were analyzed regarding their macronutrient, carbohydrate, organic acid, amino acid and mineral composition. Quantification of the main phenolic compounds in the decoctions of meadowsweet floral teas was performed by a microcolumn RP-HPLC-UV procedure; the highest content was revealed in tea. The investigation of the essential oil of four meadowsweet teas revealed the presence of 28 compounds, including simple phenols, monoterpenes, sesquiterpenes and aliphatic components. The dominance of methyl salicylate and salicylaldehyde was noted in all samples. Studies on the water soluble polysaccharides of flowers allowed us to establish their general affiliation to galactans and/or arabinogalactans with an admixture of glucans of the starch type and galacturonans as minor components. The bioactivity data demonstrated a good ability of meadowsweet teas to inhibit amylase, α-glucosidase and AGE formation. Tea samples showed antioxidant properties by the DPPH , ABTS and Br free radicals scavenging assays and the carotene bleaching assay, caused by the presence of highly active ellagitannins. The anti-complement activity of the water-soluble polysaccharide fraction of meadowsweet teas indicated their possible immune-modulating properties. beverage formulations can be expected to deliver beneficial effects due to their unique nutritional and phytochemical profiles. Potential applications as health-promoting functional products may be suggested.
[Mh] Termos MeSH primário: Antioxidantes/isolamento & purificação
Filipendula/química
Flavonoides/isolamento & purificação
Fatores Imunológicos/isolamento & purificação
Extratos Vegetais/química
Chás de Ervas/análise
[Mh] Termos MeSH secundário: Aldeídos/química
Aldeídos/isolamento & purificação
Aldeídos/farmacologia
Amilases/antagonistas & inibidores
Amilases/genética
Amilases/metabolismo
Antioxidantes/química
Antioxidantes/farmacologia
Benzotiazóis/antagonistas & inibidores
Compostos de Bifenilo/antagonistas & inibidores
Cromatografia Líquida de Alta Pressão/métodos
Proteínas do Sistema Complemento/química
Filipendula/classificação
Flavonoides/química
Flavonoides/farmacologia
Seres Humanos
Taninos Hidrolisáveis/química
Taninos Hidrolisáveis/isolamento & purificação
Taninos Hidrolisáveis/farmacologia
Fatores Imunológicos/química
Fatores Imunológicos/farmacologia
Monoterpenos/química
Monoterpenos/isolamento & purificação
Monoterpenos/farmacologia
Fenóis/química
Fenóis/isolamento & purificação
Fenóis/farmacologia
Picratos/antagonistas & inibidores
Polissacarídeos/química
Polissacarídeos/isolamento & purificação
Polissacarídeos/farmacologia
Receptor para Produtos Finais de Glicação Avançada/antagonistas & inibidores
Receptor para Produtos Finais de Glicação Avançada/genética
Receptor para Produtos Finais de Glicação Avançada/metabolismo
Salicilatos/química
Salicilatos/isolamento & purificação
Salicilatos/farmacologia
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
Especificidade da Espécie
Ácidos Sulfônicos/antagonistas & inibidores
alfa-Glucosidases/genética
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AGER protein, human); 0 (Aldehydes); 0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Hydrolyzable Tannins); 0 (Immunologic Factors); 0 (Monoterpenes); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Polysaccharides); 0 (Receptor for Advanced Glycation End Products); 0 (Salicylates); 0 (Sesquiterpenes); 0 (Sulfonic Acids); 0 (Teas, Herbal); 17K64GZH20 (salicylaldehyde); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 9007-36-7 (Complement System Proteins); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 3.2.1.- (Amylases); EC 3.2.1.20 (alpha-Glucosidases); LAV5U5022Y (methyl salicylate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


  5 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27725238
[Au] Autor:Samardzic S; Tomic M; Pecikoza U; Stepanovic-Petrovic R; Maksimovic Z
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: stevans@pharmacy.bg.ac.rs.
[Ti] Título:Antihyperalgesic activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench in a rat model of inflammation.
[So] Source:J Ethnopharmacol;193:652-656, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Meadowsweet (Filipendula ulmaria (L.) Maxim.), and dropwort (Filipendula vulgaris Moench) flowers are traditionally used to treat various ailments, including inflammatory conditions. The aim of the present study was to validate the aforementioned ethnomedicinal claim by assessing antihyperalgesic and antiedematous activities and toxicity of orally administered lyophilized flower infusions (LFIs) of F. ulmaria and F. vulgaris in experimental animals. MATERIALS AND METHODS: The phytochemical analysis of LFIs was performed by HPLC-DAD. Antihyperalgesic and antiedematous activities were estimated in a rat model of inflammation induced by intraplantar injection of carrageenan using Von Frey anesthesiometer and plethysmometer, respectively. Moreover, acute oral toxicity of LFIs in mice was evaluated by observing changes in animal behavior and mortality for a period of 14 days following the treatment. RESULTS: HPLC-DAD analysis revealed the presence of phenolic acids and flavonoids in LFIs, among which spiraeoside was identified as the principal component (56.27±1.03 and 55.67±1.82mg/g of LFI in F. ulmaria and F. vulgaris, respectively). The LFIs of F. ulmaria and F. vulgaris (100-300mg/kg; p.o.) produced significant and dose-dependent antihyperalgesic effects: ED ±SEM values were 164.8±15.4mg/kg (110.3-246.3mg/kg) and 172.2±6.2mg/kg (147.4-201.3mg/kg) for F. ulmaria and F. vulgaris, respectively. On the other hand, LFIs of both species (100-300mg/kg; p.o.) did not significantly reduce edema. Good safety profiles were evidenced in the toxicological study. The median lethal dose (LD ) of the tested extracts is likely to be greater than 2000mg/kg. CONCLUSION: The results of the present study support the use of F. ulmaria and F. vulgaris flowers in folk medicine for relieving pain in diseases with an inflammatory component.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Edema/tratamento farmacológico
Filipendula/química
Essências Florais/uso terapêutico
Hiperalgesia/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/toxicidade
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Essências Florais/isolamento & purificação
Essências Florais/toxicidade
Dose Letal Mediana
Masculino
Medicina Tradicional
Camundongos
Ratos Wistar
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Flower Essences)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


  6 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27721054
[Au] Autor:Katanic J; Boroja T; Mihailovic V; Nikles S; Pan SP; Rosic G; Selakovic D; Joksimovic J; Mitrovic S; Bauer R
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia. Electronic address: jkatanic@kg.ac.rs.
[Ti] Título:In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent.
[So] Source:J Ethnopharmacol;193:627-636, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Meadowsweet (Filipendula ulmaria (L.) Maxim, Rosaceae) has been traditionally used in most European countries for the treatment of inflammatory diseases due to its antipyretic, analgesic, astringent, and anti-rheumatic properties. However, there is little scientific evidence on F. ulmaria anti-inflammatory effects regarding its impact on cyclooxygenases enzymatic activity and in vivo assessment of anti-inflammatory potential. This study aims to reveal the anti-inflammatory activity of methanolic extracts from the aerial parts (FUA) and roots (FUR) of F. ulmaria, both in in vitro and in vivo conditions. MATERIALS AND METHODS: The characteristic phenolic compounds in F. ulmaria extracts were monitored via high performance thin layer chromatography (HPTLC). The in vitro anti-inflammatory activity of F. ulmaria extracts was evaluated using cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme assays, and an assay for determining COX-2 gene expression. The in vivo anti-inflammatory effect of F. ulmaria extracts was determined in two doses (100 and 200 mg/kg b.w.) with hot plate test and carrageenan-induced paw edema test in rats. Inflammation was also evaluated by histopathological and immunohistochemical analysis. RESULTS: FUA extract showed the presence of rutoside, spiraeoside, and isoquercitrin. Both F. ulmaria extracts at a concentration of 50µg/mL were able to inhibit COX-1 and -2 enzyme activities, whereby FUA extract (62.84% and 46.43% inhibition, respectively) was double as effective as the root extract (32.11% and 20.20%, respectively). Extracts hardly inhibited the level of COX-2 gene expression in THP-1 cells at a concentration of 25µg/mL (10.19% inhibition by FUA and 8.54% by FUR). In the hot plate test, both extracts in two doses (100 and 200mg/kg b.w.), exhibited an increase in latency time when compared with the control group (p<0.05). In the carrageenan-induced acute inflammation test, FUA at doses of 100 and 200mg/kg b.w., and FUR at 200mg/kg, were able to significantly reduce the mean maximal swelling of rat paw until 6h of treatment. Indomethacin, FUA, and FUR extracts significantly decreased inflammation score and this effect was more pronounced after 24h, compared to the control group (p<0.05). CONCLUSIONS: The observed results of in vitro and, for the first time, in vivo anti-inflammatory activity of meadowsweet extracts, provide support of the traditional use of this plant in the treatment of different inflammatory conditions. Further investigation of the anti-inflammatory compounds could reveal the mechanism of anti-inflammatory action of these extracts.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Etnofarmacologia
Filipendula/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/uso terapêutico
Linhagem Celular Tumoral
Ciclo-Oxigenase 1/genética
Ciclo-Oxigenase 1/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase/isolamento & purificação
Inibidores de Ciclo-Oxigenase/farmacologia
Inibidores de Ciclo-Oxigenase/uso terapêutico
Relação Dose-Resposta a Droga
Edema/tratamento farmacológico
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Masculino
Dor Nociceptiva/tratamento farmacológico
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cyclooxygenase Inhibitors); 0 (Plant Extracts); EC 1.14.99.1 (Cyclooxygenase 1); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  7 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26939657
[Au] Autor:Nitta Y; Yasukata F; Kitamoto N; Ito M; Sakaue M; Kikuzaki H; Ueno H
[Ad] Endereço:Department of Nutritional Science, Okayama Prefectural University, Okayama 719-1197, Japan. nitta@fhw.oka-pu.ac.jp.
[Ti] Título:Inhibition of Morganella morganii Histidine Decarboxylase Activity and Histamine Accumulation in Mackerel Muscle Derived from Filipendula ulumaria Extracts.
[So] Source:J Food Prot;79(3):463-7, 2016 Mar.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Filipendula ulmaria, also known as meadowsweet, is an herb; its extract was examined for the prevention of histamine production, primarily that caused by contaminated fish. The efficacy of meadowsweet was assessed using two parameters: inhibition of Morganella morganii histidine decarboxylase (HDC) and inhibition of histamine accumulation in mackerel. Ellagitannins from F. ulmaria (rugosin D, rugosin A methyl ester, tellimagrandin II, and rugosin A) were previously shown to be potent inhibitors of human HDC; and in the present work, these compounds inhibited M. morganii HDC, with half maximal inhibitory concentration values of 1.5, 4.4, 6.1, and 6.8 µM, respectively. Application of the extracts (at 2 wt%) to mackerel meat yielded significantly decreased histamine accumulation compared with treatment with phosphate-buffered saline as a control. Hence, F. ulmaria exhibits inhibitory activity against bacterial HDC and might be effective for preventing food poisoning caused by histamine.
[Mh] Termos MeSH primário: Filipendula/química
Histamina/metabolismo
Histidina Descarboxilase/metabolismo
Morganella morganii/efeitos dos fármacos
Perciformes/microbiologia
Alimentos Marinhos/microbiologia
[Mh] Termos MeSH secundário: Animais
Contaminação de Alimentos/prevenção & controle
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos/prevenção & controle
Histidina Descarboxilase/antagonistas & inibidores
Taninos Hidrolisáveis/farmacologia
Morganella morganii/enzimologia
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts); 820484N8I3 (Histamine); EC 4.1.1.22 (Histidine Decarboxylase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-15-313


  8 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26845709
[Au] Autor:Bijttebier S; Van der Auwera A; Voorspoels S; Noten B; Hermans N; Pieters L; Apers S
[Ad] Endereço:University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
[Ti] Título:A First Step in the Quest for the Active Constituents in Filipendula ulmaria (Meadowsweet): Comprehensive Phytochemical Identification by Liquid Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry.
[So] Source:Planta Med;82(6):559-72, 2016 Apr.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Filipendula ulmaria (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic and antirheumatic. Extracts of Filipendulae herba are on the market in the European Union as food supplements. Nevertheless, its active constituents remain to be revealed. During this study, the phytochemical composition of Filipendulae Ulmariae Herba was comprehensively characterised for the first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass mass spectrometry methods. Selective ion fragmentation experiments with a hybrid quadrupole-orbital trap mass spectrometer significantly contributed to compound identification: a total of 119 compounds were tentatively identified, 69 new to F. ulmaria. A rich diversity of phenolic constituents was detected and only a few non-phenolic phytochemicals were observed. Metabolisation and pharmacological studies should be conducted to investigate which of these constituents or metabolites there of contribute to the activity of F. ulmaria after oral intake.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Filipendula/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Flavonoides/análise
Flavonoides/química
Fenóis/análise
Fenóis/química
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/química
Fitosteróis/análise
Fitosteróis/química
Plantas Medicinais/química
Proantocianidinas/análise
Proantocianidinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phenols); 0 (Phytochemicals); 0 (Phytosterols); 0 (Proanthocyanidins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-101943


  9 / 32 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26303017
[Au] Autor:Matic S; Katanic J; Stanic S; Mladenovic M; Stankovic N; Mihailovic V; Boroja T
[Ad] Endereço:Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia. Electronic address: sanjamatic@kg.ac.rs.
[Ti] Título:In vitro and in vivo assessment of the genotoxicity and antigenotoxicity of the Filipendula hexapetala and Filipendula ulmaria methanol extracts.
[So] Source:J Ethnopharmacol;174:287-92, 2015 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The two species of Filipendula genus, Filipendula hexapetala Gilib. and Filipendula ulmaria (L.) Maxim are a traditional herbal medicine widely used to treat haemorrhoids, diarrhoea, fever, rheumatism and arthritic pain, kidney problems, to stop bleeding, and the common cold, as well as food supplements. However, no scientific study has been performed to validate genotoxic and/or antigenotoxic potentials of these two Filipendula species. AIM OF THE STUDY: The aim of the present study was to examine the genotoxic and possible in vitro and in vivo DNA protection potential of methanol extracts of F. hexapetala and F. ulmaria. MATERIALS AND METHODS: The genotoxicity of different concentrations of F. hexapetala and F. ulmaria methanol extracts from roots and aerial parts (20, 40 and 80 mg/ml), mixed with standard food for Drosophila, was evaluated in vivo in the anterior midgut of Drosophila melanogaster using a modified alkaline comet assay. The protective effects of the highest dose of extracts were observed in somatic cells of third-instar larvae against ethyl methanesulphonate (EMS)-induced genotoxicity. Also, DNA protection activity of methanol extracts from F. hexapetala and F. ulmaria (100, 200, and 400 µg/ml) against hydroxyl radical-induced DNA damage was determined under in vitro conditions. RESULTS: The results showed that methanol extracts from the root and aerial part of F. hexapetala at a concentration of 20mg/ml indicated the absence of genotoxicity. Also, there were no statistically significant differences in total scores between any of the groups treated with F. ulmaria root extract and the negative control group, while F. ulmaria aerial part extract possess weak genotoxic effects depending on the concentrations. The percentage reduction in DNA damage was more evident in the group of larvae simultaneously treated with EMS and the highest dose of F. hexapetala root or aerial part extracts and F. ulmaria root extract (91.02, 80.21, and 87.5%, respectively) and less expressive in the group simultaneously treated with F. ulmaria aerial part extract (54.7%). F. hexapetala root and aerial part extracts and F. ulmaria root extract possess strong capabilities to protect DNA from being damaged by hydroxyl radicals. CONCLUSIONS: It can be concluded that F. hexapetala root and aerial part extracts and F. ulmaria root extract demonstrated the absence of genotoxic activity. The extracts appeared to have antigenotoxic effect, reducing the levels of DNA damage induced by EMS by more than 80%. Also, F. hexapetala root and aerial part extracts and F. ulmaria root extracts could effectively protect against hydroxyl radical-induced DNA damage.
[Mh] Termos MeSH primário: Filipendula
Metanol/toxicidade
Componentes Aéreos da Planta/toxicidade
Extratos Vegetais/toxicidade
Raízes de Plantas/toxicidade
[Mh] Termos MeSH secundário: Animais
Dano ao DNA/efeitos dos fármacos
Dano ao DNA/fisiologia
Drosophila melanogaster
Testes de Mutagenicidade/métodos
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150826
[St] Status:MEDLINE


  10 / 32 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26210209
[Au] Autor:Shilova IV; Suslov NI; Amelchenko VP
[Ad] Endereço:E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, inessashilova@gmail.com.
[Ti] Título:Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions.
[So] Source:Bull Exp Biol Med;159(3):376-9, 2015 Jul.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nootropic activity of water extract fractions from aerial parts of Filipendula vulgaris Moench was demonstrated on the models of hermetic volume hypoxia, conditioned passive avoidance response, open field test, and forced swimming with a load. The fractions stimulated hypoxic resistance, normalized orientation and exploratory behavior, improved conditioned response reproduction during testing after hypoxic injury, and increased exercise tolerance. Fractionation of the extract led to dissociation of the effect components, which suggests that individual constituents have specific characteristics. Ethylacetate fraction exhibited most pronounced nootropic activity and was superior to plant extract by some characteristics. The detected effects seemed to be caused by modulation of the hippocampus activity the under the effects of phenol and triterpene compounds.
[Mh] Termos MeSH primário: Filipendula/química
Nootrópicos/farmacologia
Extratos Vegetais/química
Água/química
[Mh] Termos MeSH secundário: Animais
Comportamento Exploratório/efeitos dos fármacos
Masculino
Camundongos
Nootrópicos/química
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nootropic Agents); 0 (Plant Extracts); 059QF0KO0R (Water)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150811
[Lr] Data última revisão:
150811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150727
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-2967-9



página 1 de 4 ir para página            
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde