Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.859.937.500.288 [Categoria DeCS] Referências encontradas : 45 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28110011 [Au] Autor: Yoon SJ; Hong S; Kwon BO; Ryu J; Lee CH; Nam J; Khim JS [Ad] Endereço: School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea. [Ti] Título: Distributions of persistent organic contaminants in sediments and their potential impact on macrobenthic faunal community of the Geum River Estuary and Saemangeum Coast, Korea. [So] Source: Chemosphere;173:216-226, 2017 Apr. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Over the last 30 years, the Geum River Estuary and Saemangeum Coast have been subject to major environmental changes, including dike construction, reclamation, and development of industrial complexes. This study aimed to: 1) investigate the occurrence of polycyclic aromatic hydrocarbons (PAHs), alkylphenols (APs), and styrene oligomers (SOs), 2) identify the sources of sedimentary organic matter, and 3) determine key environmental factors controlling the macrozoobenthos community structure. A total of 58 surface sediments were collected from the estuary and coastal area in 2014. Specific persistent organic contaminants (POCs), including 24 PAHs, 6 APs, and 10 SOs were measured. PAHs, APs, and SOs were detected in the sediments at all sites, with concentrations varying among sites. Although POCs concentrations were generally below the Canadian sediment quality guidelines, relatively greater concentrations of POCs were found at some sites adjacent to industrial complexes and the estuarine area. Sediment organic carbon, total nitrogen, and the stable carbon isotope ratio (δ C) were determined. Some sites near watergate had about 2-3‰ lighter δ C values compared to other areas, indicating that these sites are affected by terrestrial organic matter. The number of species in the macrofaunal community was significantly correlated with δ C values (p < 0.001), positively, suggesting that the origin of sedimentary organic matter is important for controlling the macrozoobenthos distribution. Overall, this research provides information about the level and sources of sediment pollution, the origins of organic matter, and the relationships with the macrofaunal community. [Mh] Termos MeSH primário: Estuários Sedimentos Geológicos/química Geum/efeitos dos fármacos Hidrocarbonetos Aromáticos Policíclicos/toxicidade Rios/química Poluentes Químicos da Água/toxicidade [Mh] Termos MeSH secundário: Canadá Monitoramento Ambiental Poluição Ambiental Geum/crescimento & desenvolvimento Hidrocarbonetos Aromáticos Policíclicos/análise República da Coreia Poluentes Químicos da Água/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polycyclic Aromatic Hydrocarbons); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170411 [Lr] Data última revisão: 170411 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170123 [St] Status: MEDLINE

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[PMID]: 27474082 [Au] Autor: Shi X; Li C; Zhao L; Si M; Zhu L; Xin K; Chen C; Wang Y; Shen X; Zhang L [Ad] Endereço: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China. [Ti] Título: Rhizobium gei sp. nov., a bacterial endophyte of Geum aleppicum. [So] Source: Int J Syst Evol Microbiol;66(10):4282-4288, 2016 Oct. [Is] ISSN: 1466-5034 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A bacterial strain, designated as ZFJT-2T, was isolated from the stem of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi Province, north-west China. Cells of strain ZFJT-2T were Gram-stain-negative, strictly aerobic, rod-shaped and motile by means of a single polar flagellum. The major fatty acids were summed feature 8 (comprising C18 : 1ω7c and/or C18 : 1ω6c), C16 : 0, 11-methyl C18 : 1ω7c and summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c), and the DNA G+C content was 58.3 mol% (HPLC). Phylogenetic analyses based on 16S rRNA gene sequences showed that strain ZFJT-2T was a member of the genus Rhizobium and was most closely related to Rhizobium giardinii KACC 10720T (98.6 % similarity) and Rhizobium herbae CCBAU 83011T (98.5 %). The low levels of sequence similarity found between the atpD, recA and glnII gene sequences of strain ZFJT-2T and those of recognized species of the genus Rhizobium (no more than 94.4, 87.2 and 89.5 %, respectively) indicated that it may represent a separate species of the genus Rhizobium. The DNA-DNA relatedness values for strain ZFJT-2T with respect to R. giardinii KACC 10720T and R. herbae CCBAU 83011T were 17.6 and 41.9 %, respectively. On the basis of phenotypic, phylogenetic and genotypic data, strain ZFJT-2T is considered to represent a novel species of the genus Rhizobium, for which the name Rhizobium gei sp. nov. is proposed. The type strain is ZFJT-2T (=CCTCC AB 2013015T=KCTC 32301T=LMG 27603T). [Mh] Termos MeSH primário: Geum/microbiologia Filogenia Rhizobium/classificação [Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana Composição de Bases China DNA Bacteriano/genética Endófitos/classificação Ácidos Graxos/química Genes Bacterianos Hibridização de Ácido Nucleico Caules de Planta/microbiologia RNA Ribossômico 16S/genética Rhizobium/genética Rhizobium/isolamento & purificação Análise de Sequência de DNA [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160731 [St] Status: MEDLINE [do] DOI: 10.1099/ijsem.0.001348

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[PMID]: 27353564 [Au] Autor: Lobbens ES; Breydo L; Skamris T; Vestergaard B; Jäger AK; Jorgensen L; Uversky V; van de Weert M [Ad] Endereço: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark. [Ti] Título: Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation. [So] Source: Biochim Biophys Acta;1864(9):1160-1169, 2016 09. [Is] ISSN: 0006-3002 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The presence of Lewy bodies and Lewy neurites is a major pathological hallmark of Parkinson's disease and is hypothesized to be linked to disease development, although this is not yet conclusive. Lewy bodies and Lewy neurites primarily consist of fibrillated α-Synuclein; yet, there is no treatment available targeting stabilization of α-Synuclein in its native state. The aim of the present study was to investigate the inhibitory activity of an ethanolic extract of Geum urbanum against α-Synuclein fibrillation and examine the structural changes of α-Synuclein in the presence of the extract. The anti-fibrillation and anti-aggregation activities of the plant extract were monitored by thioflavin T fibrillation assays and size exclusion chromatography, while structural changes were followed by circular dichroism, Fourier transform infrared spectroscopy, intrinsic fluorescence, small angle X-ray scattering and electron microscopy. Since the extract is a complex mixture, structure-function relationships could not be determined. Under the experimental conditions investigated, Geum urbanum was found to inhibit α-Synuclein fibrillation in a concentration dependent way, and to partly disintegrate preformed α-Synuclein fibrils. Based on the structural changes of α-Synuclein in the presence of extract, we propose that Geum urbanum delays α-Synuclein fibrillation either by reducing the fibrillation ability of one or more of the aggregation prone intermediates or by directing α-Synuclein aggregation towards a non-fibrillar state. However, whether these alterations of the fibrillation pathway lead to less pathogenic species is yet to be determined. [Mh] Termos MeSH primário: Amiloide/química Geum/química Extratos Vegetais/química Agregados Proteicos alfa-Sinucleína/química [Mh] Termos MeSH secundário: Amiloide/antagonistas & inibidores Seres Humanos Soluções Espectrometria de Fluorescência Espectroscopia de Infravermelho com Transformada de Fourier Tiazóis alfa-Sinucleína/antagonistas & inibidores [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Amyloid); 0 (Plant Extracts); 0 (Protein Aggregates); 0 (Solutions); 0 (Thiazoles); 0 (alpha-Synuclein); 2390-54-7 (thioflavin T) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171004 [Lr] Data última revisão: 171004 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160630 [St] Status: MEDLINE

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[PMID]: 27139570 [Au] Autor: Granica S; Klebowska A; Kosinski M; Piwowarski JP; Dudek MK; Kazmierski S; Kiss AK [Ad] Endereço: Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. [Ti] Título: Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases. [So] Source: J Ethnopharmacol;188:1-12, 2016 Jul 21. [Is] ISSN: 1872-7573 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: Geum urbanum L. (wood avens) root infusions and decoctions have been used externally for reducing the bleeding and inflammation of gums (gingivitis), and mucous membranes. AIM OF THE STUDY: Taking into account that primed and hyperactivated neutrophils are an important factor in the transition from gingivitis to periodontitis, we investigated the effects of phytochemically characterised (HPLC-DAD-MS(n)) extracts of different polarity from Geum urbanum root on oxidative burst, elastase, metalloproteinase 9 (MMP-9), interleukin 8 (IL-8) and 1ß (IL-1ß), tumour necrosis factor (TNF-α) release, expression of adhesion molecules (CD62L and CD11b) and delayed apoptosis in stimulated neutrophils. As gemin A is a dominating compound in a raw material, so we considered its activity in parallel with the positive control quercetin. MATERIALS AND METHODS: The extracts were characterised by HPLC-DAD- MS(n) method. The inhibition of ROS production by stimulated neutrophils was determined using luminol dependent chemiluminescence method. The effect on MMP-9, IL-1ß, TNF-α and IL-8 production by neutrophils was measured by enzyme-linked immunosorbent assay (ELISA). Neutrophil elastase release was established spectrophotometrically. The expression of adhesion molecules and the apoptosis of neutrophils was analyzed with flow cytometry. RESULTS: The main compounds detected in the extract belong mainly to the group of ellagitannin: pedunculagin, stachyurin, casuarynin and gemin A, and ellagic acid derivatives. Procyanidins and one complex tannin were found as minor compounds. Gemin A significantly affected the functions of stimulated neutrophils by reducing the surface expression of CD11b, and inhibiting the release of reactive oxygen species, and proteases (elastase, MMP-9), chemokines and cytokines (interleukins IL-8, IL-1ß). Interestingly, gemin A stimulated the release of TNF-α, which may be one of the stimulators of apoptosis of neutrophil cells. The primary aqueous extract, the ethyl acetate and the butanolic fractions, all containing the highest level of gemin A, have exerted similar but weaker activity. CONCLUSION: The modulating effect on the neutrophils function of extracts, and its main constituent gemin A, support the traditional use of this plant material in cavity inflammation including mucositis, gingivitis and periodontosis. [Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia Geum/química Ativação de Neutrófilo/efeitos dos fármacos Neutrófilos/efeitos dos fármacos Doenças Periodontais/tratamento farmacológico Extratos Vegetais/farmacologia Raízes de Plantas/química [Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação Anti-Inflamatórios/toxicidade Apoptose/efeitos dos fármacos Biomarcadores/metabolismo Moléculas de Adesão Celular/metabolismo Células Cultivadas Cromatografia Líquida de Alta Pressão Citocinas/metabolismo Relação Dose-Resposta a Droga Gengivite/tratamento farmacológico Gengivite/imunologia Gengivite/metabolismo Seres Humanos Mediadores da Inflamação/metabolismo Elastase de Leucócito/metabolismo Lipopolissacarídeos/farmacologia Espectrometria de Massas Metaloproteinase 9 da Matriz/metabolismo Mucosite/tratamento farmacológico Mucosite/imunologia Mucosite/metabolismo Neutrófilos/imunologia Neutrófilos/metabolismo Doenças Periodontais/imunologia Doenças Periodontais/metabolismo Periodontite/tratamento farmacológico Periodontite/imunologia Periodontite/metabolismo Fitoterapia Extratos Vegetais/isolamento & purificação Extratos Vegetais/toxicidade Plantas Medicinais Espécies Reativas de Oxigênio/metabolismo Explosão Respiratória/efeitos dos fármacos Transdução de Sinais/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Cell Adhesion Molecules); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Reactive Oxygen Species); EC 3.4.21.37 (Leukocyte Elastase); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170421 [Lr] Data última revisão: 170421 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160504 [St] Status: MEDLINE

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[PMID]: 25604345 [Au] Autor: Zhu L; Si M; Li C; Xin K; Chen C; Shi X; Huang R; Zhao L; Shen X; Zhang L [Ad] Endereço: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR China. [Ti] Título: Sphingomonas gei sp. nov., isolated from roots of Geum aleppicum. [So] Source: Int J Syst Evol Microbiol;65(Pt 4):1160-6, 2015 Apr. [Is] ISSN: 1466-5034 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A yellow-pigmented bacterium, designated strain ZFGT-11(T), was isolated from roots of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi Province, north-west China, and was subjected to a taxonomic study by using a polyphasic approach. Cells of strain ZFGT-11(T) were Gram-stain-negative, strictly aerobic rods that were surrounded by a thick capsule and were motile by means of a single polar flagellum. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain ZFGT-11(T) was a member of the genus Sphingomonas and was closely related to Sphingomonas naasensis KACC 16534(T) (97.6% similarity), Sphingomonas kyeonggiense JCM 18825(T) (96.8%), Sphingomonas asaccharolytica IFO 15499(T) (96.7%) and Sphingomonas leidyi DSM 4733(T) (96.6%). The predominant respiratory quinone was ubiquinone-10 (Q-10) and the major cellular fatty acids were summed feature 8 (comprising C(18 : 1)ω7c and/or C(18 : 1)ω6c), C(17 : 1)ω6c, C(14 : 0) 2-OH, C(16 : 0) and C(15 : 0) 2-OH. The major polyamine of strain ZFGT-11(T) was sym-homospermidine. Phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylmonomethylethanolamine, phosphatidylcholine, sphingoglycolipid, two unidentified aminoglycolipids, two unidentified phospholipids and two unidentified lipids were detected in the polar lipid profile. The DNA G+C content was 66.8 mol%. DNA-DNA relatedness for strain ZFGT-11(T) with respect to its closest phylogenetic relative S. naasensis KACC 16534(T) was 26.2±4.8% (mean±SD). On the basis of data from the present polyphasic taxonomic study, strain ZFGT-11(T) is considered to represent a novel species of the genus Sphingomonas , for which the name Sphingomonas gei sp. nov. is proposed. The type strain is ZFGT-11(T) ( = CCTCC AB 2013306(T) = KCTC 32449(T) = LMG 27608(T)). [Mh] Termos MeSH primário: Geum/microbiologia Filogenia Microbiologia do Solo Sphingomonas/classificação [Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana Composição de Bases China DNA Bacteriano/genética Ácidos Graxos/química Dados de Sequência Molecular Hibridização de Ácido Nucleico Fosfolipídeos/química Pigmentação Raízes de Plantas/microbiologia RNA Ribossômico 16S/genética Análise de Sequência de DNA Espermidina/análogos & derivados Espermidina/química Sphingomonas/genética Sphingomonas/isolamento & purificação Ubiquinona/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 0IJ25X1H4R (sym-homospermidine); 1339-63-5 (Ubiquinone); I7T5V2W47R (Ubiquinone Q2); U87FK77H25 (Spermidine) [Em] Mês de entrada: 1510 [Cu] Atualização por classe: 151124 [Lr] Data última revisão: 151124 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150122 [St] Status: MEDLINE [do] DOI: 10.1099/ijs.0.000074

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[PMID]: 25511044 [Au] Autor: Wang XF; Hassani D; Cheng ZW; Wang CY; Wu J [Ad] Endereço: School of Life and Environment Science, Huangshan University, Huangshan, China wxf74hs@163.com. [Ti] Título: Allelopathy of the invasive plant Bidens frondosa on the seed germination of Geum japonicum var. chinense. [So] Source: Genet Mol Res;13(4):10592-8, 2014 Dec 12. [Is] ISSN: 1676-5680 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Five gradient concentrations (0.02, 0.04, 0.06, 0.08, and 0.10 g/mL) of leaching liquors from the roots, stems, and leaves of the invasive plant Bidens frondosa were used as conditioning fluid to examine its influence on seed germination conditions of the native plant Geum japonicum var. chinense in Huangshan. All leaching liquors of organs suppressed the seed germination of Geum japonicum var. chinense and reduced the final germination percentage and rate, and increased the germination inhibition rate, with a bimodal dependence on concentration. The leaching liquor inhibited the seed germination significantly at the concentration of 0.02 g/mL respectively. The seed germination was also inhibited as the concentration reached to 0.04 g/mL and beyond. Hence the allelopathic effects of the organs were significantly enhanced respectively. This phenomenon represented the presence of allelopathy substances in the root, stem and leaf of Bidens frondosa. [Mh] Termos MeSH primário: Alelopatia/efeitos dos fármacos Germinação/efeitos dos fármacos Geum/efeitos dos fármacos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Bidens/química Geum/crescimento & desenvolvimento Extratos Vegetais/química Folhas de Planta/química Raízes de Plantas/química Caules de Planta/química Plântulas/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Plant Extracts) [Em] Mês de entrada: 1510 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141217 [St] Status: MEDLINE [do] DOI: 10.4238/2014.December.12.22

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[PMID]: 25205798 [Au] Autor: Zhu L; Long M; Si M; Wei L; Li C; Zhao L; Shen X; Wang Y; Zhang L [Ad] Endereço: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR China. [Ti] Título: Asticcacaulis endophyticus sp. nov., a prosthecate bacterium isolated from the root of Geum aleppicum. [So] Source: Int J Syst Evol Microbiol;64(Pt 12):3964-9, 2014 Dec. [Is] ISSN: 1466-5034 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A strictly aerobic, light-yellow-coloured, stalked bacterium, designated strain ZFGT-14(T), was isolated from the root of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi province, north-west China, and was subjected to a taxonomic study using a polyphasic approach. This novel isolate grew at 7-33 °C (optimum 25-28 °C) and pH 6.0-10.0 (optimum pH 7.0-8.0). Flexirubin-type pigments were not produced. Cells were Gram-stain-negative, rod-shaped and motile with a single polar flagellum. The predominant respiratory quinone was Q-10. The major cellular fatty acids were summed feature 8 (comprising C18 : 1ω7c/C18 : 1ω6c), C16 : 0, C19 : 0 cyclo ω8c and summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c) and the major polar lipids were phosphatidylglycerol and glycolipids. The DNA G+C content was 57.8 mol%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain ZFGT-14(T) was most closely related to the genus Asticcacaulis and had low sequence similarity (95.0-95.9 %) with all species with validly published names within the genus Asticcacaulis. Based on the phenotypic, phylogenetic and genotypic data, strain ZFGT-14(T) is considered to represent a novel species of the genus Asticcacaulis, for which the name Asticcacaulis endophyticus sp. nov. is proposed. The type strain is ZFGT-14(T) ( = CCTCC AB 2013012(T) = KCTC 32296(T) = LMG 27605(T)). [Mh] Termos MeSH primário: Caulobacteraceae/classificação Geum/microbiologia Filogenia Raízes de Plantas/microbiologia [Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana Composição de Bases Caulobacteraceae/genética Caulobacteraceae/isolamento & purificação China DNA Bacteriano/genética Ácidos Graxos/química Glicolipídeos/química Dados de Sequência Molecular Fosfatidilgliceróis/química RNA Ribossômico 16S/genética Análise de Sequência de DNA Ubiquinona/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Glycolipids); 0 (Phosphatidylglycerols); 0 (RNA, Ribosomal, 16S); 1339-63-5 (Ubiquinone); I7T5V2W47R (Ubiquinone Q2) [Em] Mês de entrada: 1502 [Cu] Atualização por classe: 151124 [Lr] Data última revisão: 151124 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140911 [St] Status: MEDLINE [do] DOI: 10.1099/ijs.0.066605-0

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[PMID]: 24492623 [Au] Autor: Chen H; Cheng L; Lin X; Zhou X; Cai Z; Li M [Ad] Endereço: 1] The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, PR China [2] Joint Laboratory For Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. [Ti] Título: Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts. [So] Source: Sci Rep;4:3962, 2014 Feb 04. [Is] ISSN: 2045-2322 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Chronic coronary heart disease (cCHD) is characterized by atherosclerosis, which progressively narrows the coronary artery lumen and impairs myocardial blood flow. Restoration of occluded coronary vessels with newly formed collaterals remains an ideal therapeutic approach due to the need for redirecting blood flow into the ischemic heart. In this study, we investigated the effect of an active fraction isolated from Geum joponicum (AFGJ) on angiogenesis in cCHD hearts. Our results demonstrated that AFGJ not only enhanced capillary tube formation of endothelial cells, but also promoted the growth of new coronary collaterals (at the diameter 0.021-0.21 mm) in the ischemic region of hearts in rat cCHD model. Our study also indicated that the growth of new collaterals in ischemic hearts resulted in improved functional recovery of the cCHD hearts as demonstrated by ECG and echocardiography analyses. These data suggest that AFGJ may provide a novel therapeutic method for effective treatment of cCHD. [Mh] Termos MeSH primário: Doença das Coronárias/tratamento farmacológico Geum/metabolismo Infarto do Miocárdio/tratamento farmacológico Neovascularização Fisiológica/efeitos dos fármacos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Animais Aterosclerose/tratamento farmacológico Proliferação Celular Células Cultivadas Vasos Coronários/efeitos dos fármacos Ecocardiografia Coração Masculino Ratos Ratos Sprague-Dawley [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Plant Extracts) [Em] Mês de entrada: 1512 [Cu] Atualização por classe: 140204 [Lr] Data última revisão: 140204 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140205 [St] Status: MEDLINE [do] DOI: 10.1038/srep03962

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[PMID]: 24477814 [Au] Autor: Zhang L; Wei L; Zhu L; Li C; Wang Y; Shen X [Ad] Endereço: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China. [Ti] Título: Pseudoxanthomonas gei sp. nov., a novel endophytic bacterium isolated from the stem of Geum aleppicum. [So] Source: Antonie Van Leeuwenhoek;105(4):653-61, 2014 Apr. [Is] ISSN: 1572-9699 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: A Gram stain-negative, strictly aerobic, rod-shaped, non-motile and deep-yellow-coloured bacterial strain, designated ZFJR-3(T), was isolated from the stem of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi Province, north-west China, and characterized by using a polyphasic approach. The novel isolate grew optimally at 25-28 °C and in the absence of NaCl. Flexirubin-type pigments were produced. The predominant respiratory quinone was ubiquinone-8 (Q-8) and the major cellular fatty acids were iso-C15:0 (29.2 %), iso-C16:0 (18.5 %), summed feature 9 (comprising iso-C17:1 ω9c and/or C16:0 10-methyl; 8.8 %), C16:1 ω7c alcohol (8.8 %), iso-C11:0 3-OH (6.9 %) and iso-C11:0 (6.8 %). The DNA G+C content was 66.1 mol %. The only polyamine was spermidine and the major polar lipids were diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylglycerol. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain ZFJR-3(T) belongs to the genus Pseudoxanthomonas and was most closely related to Pseudoxanthomonas yeongjuensis KCTC 22757(T) (16S rRNA gene sequence similarity, 99.0 %) and Pseudoxanthomonas sacheonensis KCTC 22080(T) (98.0 %). The levels of 16S rRNA gene sequence similarity with respect to other Pseudoxanthomonas species with validly published names were less than 96.5 %. DNA-DNA relatedness values for strain ZFJR-3(T) with respect to its closely related neighbours P. yeongjuensis KCTC 22757(T) and P. sacheonensis KCTC 22080(T) were 48.7 and 36.3 %, respectively. Based on the phenotypic, phylogenetic and genotypic data, strain ZFJR-3(T) is considered to represent a novel species of the genus Pseudoxanthomonas, for which the name Pseudoxanthomonas gei sp. nov. is proposed. The type strain is ZFJR-3(T) (=CCTCC AB 2013020(T) =KCTC 32298(T)). [Mh] Termos MeSH primário: Geum/microbiologia Xanthomonadaceae/classificação Xanthomonadaceae/isolamento & purificação [Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana Composição de Bases China Análise por Conglomerados DNA Bacteriano/química DNA Bacteriano/genética DNA Ribossômico/química DNA Ribossômico/genética Endófitos/classificação Endófitos/genética Endófitos/isolamento & purificação Endófitos/fisiologia Ácidos Graxos/análise Dados de Sequência Molecular Hibridização de Ácido Nucleico Fosfolipídeos/análise Filogenia Poliaminas/análise Quinonas/análise RNA Ribossômico 16S/genética Análise de Sequência de DNA Xanthomonadaceae/genética Xanthomonadaceae/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Fatty Acids); 0 (Phospholipids); 0 (Polyamines); 0 (Quinones); 0 (RNA, Ribosomal, 16S) [Em] Mês de entrada: 1410 [Cu] Atualização por classe: 140310 [Lr] Data última revisão: 140310 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140131 [St] Status: MEDLINE [do] DOI: 10.1007/s10482-014-0119-2

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MEDLINE

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[PMID]: 24112704 [Au] Autor: Dean SL; Farrer EC; Taylor DL; Porras-Alfaro A; Suding KN; Sinsabaugh RL [Ad] Endereço: Department of Biology, University of New Mexico, Albuquerque, NM, USA. [Ti] Título: Nitrogen deposition alters plant-fungal relationships: linking belowground dynamics to aboveground vegetation change. [So] Source: Mol Ecol;23(6):1364-78, 2014 Mar. [Is] ISSN: 1365-294X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Nitrogen (N) deposition rates are increasing globally due to anthropogenic activities. Plant community responses to N are often attributed to altered competitive interactions between plants, but may also be a result of microbial responses to N, particularly root-associated fungi (RAF), which are known to affect plant fitness. In response to N, Deschampsia cespitosa, a codominant plant in the alpine tundra at Niwot Ridge (CO), increases in abundance, while Geum rossii, its principal competitor, declines. Importantly, G. rossii declines with N even in the absence of its competitor. We examined whether contrasting host responses to N are associated with altered plant-fungal symbioses, and whether the effects of N are distinct from effects of altered plant competition on RAF, using 454 pyrosequencing. Host RAF communities were distinct (only 9.4% of OTUs overlapped). N increased RAF diversity in G. rossii, but decreased it in D. cespitosa. D. cespitosa RAF communities were more responsive to N than G. rossii RAF communities, perhaps indicating a flexible microbial community aids host adaptation to nutrient enrichment. Effects of removing D. cespitosa were distinct from effects of N on G. rossii RAF, and D. cespitosa presence reversed RAF diversity response to N. The most dominant G. rossii RAF order, Helotiales, was the most affected by N, declining from 83% to 60% of sequences, perhaps indicating a loss of mutualists under N enrichment. These results highlight the potential importance of belowground microbial dynamics in plant responses to N deposition. [Mh] Termos MeSH primário: Fungos/fisiologia Geum/microbiologia Nitrogênio/química Poaceae/fisiologia Microbiologia do Solo Solo/química [Mh] Termos MeSH secundário: Colorado DNA Fúngico/genética Ecossistema Modelos Genéticos Filogenia Raízes de Plantas/microbiologia Análise de Sequência de DNA Simbiose [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 0 (DNA, Fungal); 0 (Soil); N762921K75 (Nitrogen) [Em] Mês de entrada: 1406 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 131012 [St] Status: MEDLINE [do] DOI: 10.1111/mec.12541

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