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Pesquisa : B01.650.940.800.575.912.250.859.937.500.522 [Categoria DeCS]
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[PMID]:29351879
[Au] Autor:Szopa A; Starzec A; Ekiert H
[Ad] Endereço:Chair and Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, ul. Medyczna 9, 30-688 Kraków, Poland. Electronic address: a.szopa@uj.edu.pl.
[Ti] Título:The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia נprunifolia.
[So] Source:J Photochem Photobiol B;179:91-97, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Shoot cultures of Aronia melanocarpa, A. arbutifolia and A. × prunifolia were maintained on Murashige and Skoog medium with 1 mg/l each of BA and NAA under monochromatic lights (far-red, red, blue lights, UV-A-irradiation), in darkness, and under white light (control). HPLC-DAD analyses of 19 phenolic acids and 11 flavonoids in methanolic extracts from the shoots revealed in all of them the presence of three depsides (chlorogenic, neochlorogenic and rosmarinic acids), protocatechuic acid, four flavonoid glycosides (cynaroside, quercitrin, hyperoside and rutoside), and additionally, in A. arbutifolia, 3,4-dihydroxyphenylacetic acid. Depending on light quality, the total amounts of these metabolites increased 1.8-5.9 times, reaching maximum values under blue light: 527.40 and 144.61 mg 100 g DW (A. melanocarpa), 543.27 and 85.82 mg 100 g DW (A. arbutifolia) and 1615.18 and 220.65 mg 100 g DW (A. × prunifolia), respectively. The maximum total amounts were 1.3-3.6 times higher than under white light. The quantities of individual metabolites changed from 1.2 to 11.0 times, with high amounts of neochlorogenic acid and quercitrin in A. melanocarpa (243.35 and 75.64 mg 100 g DW), and of chlorogenic and rosmarinic acids and quercitrin in A. arbutifolia (236.52, 219.35 and 51.01 mg 100 g DW). Extremely high amounts of depsides (418.83, 644.68, 548.86 mg 100 g DW) and quercitrin (165.88 mg 100 g DW) were produced in cultures of the hybrid - A. × prunifolia. The results are potentially useful for practical applications. This is the first report documented the importance of light quality on the production of phenolic acids and flavonoids in three aronia in vitro cultures.
[Mh] Termos MeSH primário: Flavonoides/metabolismo
Hidroxibenzoatos/metabolismo
Luz
Photinia/efeitos da radiação
[Mh] Termos MeSH secundário: Biomassa
Ácido Clorogênico/análise
Ácido Clorogênico/metabolismo
Cromatografia Líquida de Alta Pressão
Cinamatos/análise
Cinamatos/metabolismo
Depsídeos/análise
Depsídeos/metabolismo
Flavonoides/análise
Hidroxibenzoatos/análise
Photinia/química
Photinia/metabolismo
Brotos de Planta/química
Brotos de Planta/metabolismo
Brotos de Planta/efeitos da radiação
Quercetina/análogos & derivados
Quercetina/análise
Quercetina/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Depsides); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); 2Y8906LC5P (quercitrin); 318ADP12RI (Chlorogenic Acid); 9IKM0I5T1E (Quercetin); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE


  2 / 164 MEDLINE  
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[PMID]:28842359
[Au] Autor:Song RY; Wang XB; Yin GP; Liu RH; Kong LY; Yang MH
[Ad] Endereço:State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
[Ti] Título:Isocoumarin derivatives from the endophytic fungus, Pestalotiopsis sp.
[So] Source:Fitoterapia;122:115-118, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo (OCOCH ) -induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC value of 3.49±0.21µg/mL.
[Mh] Termos MeSH primário: Antifúngicos/química
Xylariales/química
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Candida glabrata/efeitos dos fármacos
Endófitos/química
Isocumarinas/química
Isocumarinas/isolamento & purificação
Testes de Sensibilidade Microbiana
Estrutura Molecular
Photinia/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Isocoumarins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


  3 / 164 MEDLINE  
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[PMID]:28677983
[Au] Autor:Kang SH; Jeon YD; Moon KH; Lee JH; Kim DG; Kim W; Myung H; Kim JS; Kim HJ; Bang KS; Jin JS
[Ad] Endereço:1 Department of Oriental Pharmacy, College of Pharmacy, Wongkwang-Oriental Medicine Research Institute, Wongkwang University , Iksan, South Korea .
[Ti] Título:Aronia Berry Extract Ameliorates the Severity of Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
[So] Source:J Med Food;20(7):667-675, 2017 Jul.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a group of inflammatory conditions of the colon and small intestine. UC is a chronic inflammatory disorder of the colon and rectum that includes intervals of acute exacerbation. Although recent studies have suggested that proinflammatory cytokines might have initiated the inflammatory responses in UC, its etiology remains unclear. Aronia berries are rich in dietary polyphenols such as phenolic acids, anthocyanins, flavonoids, and proanthocyanidins with various health benefits, including antioxidant, anti-inflammatory, and antiaging activities. The objective of this study was to determine whether Aronia berry can be an effective intervention for the treatment of UC. BALB/c mice were administered 5% dextran sulfate sodium (DSS) to induce UC. They were then given Aronia berry extracts at concentrations of 10 or 100 mg/kg. During the induction of UC, the expression levels of nuclear factor-kappa B were increased in colonic epithelial cells and immune cells, leading to increased proinflammatory cytokine levels. Aronia berry extract significantly improved the clinical signs of DSS-induced UC, including body weight loss, colon length shortening, and disease activity index increase, with histological markers of colon injury. Furthermore, oral administration of Aronia berry extract inhibited prostaglandin E production in DSS-induced colitis and decreased the levels of nitric oxide, interleukin-6, and tumor necrosis factor-α in lipopolysaccharide-stimulated macrophages. These results suggest that Aronia berry extract could efficiently ameliorate clinical signs and inflammatory mediators of UC. Therefore, Aronia berry might be a promising natural treatment for UC.
[Mh] Termos MeSH primário: Colite Ulcerativa/tratamento farmacológico
Photinia/química
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Colite Ulcerativa/induzido quimicamente
Colite Ulcerativa/imunologia
Sulfato de Dextrana/efeitos adversos
Dinoprostona/imunologia
Frutas/química
Seres Humanos
Interleucina-6/genética
Interleucina-6/imunologia
Macrófagos/imunologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/genética
NF-kappa B/imunologia
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 9042-14-2 (Dextran Sulfate); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.3822


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[PMID]:28657734
[Au] Autor:Wei J; Zhang G; Zhang X; Xu D; Gao J; Fan J; Zhou Z
[Ad] Endereço:School of Life Science, Liaoning University , Shenyang, Liaoning 110036, China.
[Ti] Título:Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
[So] Source:J Agric Food Chem;65(29):5973-5984, 2017 Jul 26.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aging is the greatest risk factor for most neurodegenerative diseases, which is associated with decreasing cognitive function and significantly affecting life quality in the elderly. Computational analysis suggested that 4 anthocyanins from chokeberry fruit increased Klotho (aging-suppressor) structural stability, so we hypothesized that chokeberry anthocyanins could antiaging. To explore the effects of anthocyanins treatment on brain aging, mice treated with 15 or 30 mg/kg anthocyanins by gavage and injected D-galactose accelerated aging per day. After 8 weeks, cognitive and noncognitive components of behavior were determined. Our studies showed that anthocyanins blocked age-associated cognitive decline and response capacity in senescence accelerated mice. Furthermore, mice treated with anthocyanins-supplemented showed better balance of redox systems (SOD, GSH-PX, and MDA) in all age tests. Three major monoamines were norepinephrine, dopamine, and 5-hydroxytryptamine, and their levels were significantly increased; the levels of inflammatory cytokines (COX2, TGF-ß1, and IL-1) transcription and DNA damage were decreased significantly in brains of anthocyanins treated mice compared to aged models. The DNA damage signaling pathway was also regulated with anthocyanins. Our results suggested that anthocyanins was a potential approach for maintaining thinking and memory in aging mice, possibly by regulating the balance of redox system and reducing inflammation accumulation, and the most important factor was inhibiting DNA damage.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Antocianinas/administração & dosagem
Encéfalo/efeitos dos fármacos
Photinia/química
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Envelhecimento/psicologia
Animais
Encéfalo/metabolismo
Encéfalo/fisiopatologia
Cognição/efeitos dos fármacos
Suplementos Nutricionais/análise
Frutas/química
Seres Humanos
Interleucina-1/metabolismo
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Interleukin-1); 0 (Plant Extracts); 0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02136


  5 / 164 MEDLINE  
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[PMID]:28524107
[Au] Autor:Juranovic Cindric I; Zeiner M; Mihajlov-Konanov D; Stingeder G
[Ad] Endereço:Division of Analytical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia. ijuranovic@chem.pmf.hr.
[Ti] Título:Inorganic Macro- and Micronutrients in "Superberries" Black Chokeberries (Aronia melanocarpa) and Related Teas.
[So] Source:Int J Environ Res Public Health;14(5), 2017 May 18.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Black chokeberries ( ) are considered to be functional food containing high amounts of anthocyanins, phenols, antioxidants, vitamins and minerals. Whereas organic compounds are well studied, there is little research on the mineral composition of the chokeberries. Thus, the presented study is focused on the determination of Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Se, Sr and Zn in black chokeberry fruits and infusions to study the metals' extractability. The nutrients Ca, K and Mg are present in the fruits (dried matter) at g/kg level, whereas the other elements are present from µg/kg up to mg/kg level. The extraction yields of the metals from the infusion range from 4 (Al, Mn) up to 44% (Na). The toxic elements present do not pose any health risk when berries or infusions are consumed. Concluding, Aronia berries, as well as infusions derived from them, are a good dietary source of essential metals in addition to the organic compounds also contained.
[Mh] Termos MeSH primário: Frutas/química
Metais/análise
Micronutrientes/análise
Photinia
Chás de Ervas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 0 (Micronutrients); 0 (Teas, Herbal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


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[PMID]:28407915
[Au] Autor:Jankovic B; Marinovic-Cincovic M; Jankovic M
[Ad] Endereço:Faculty of Physical Chemistry, Department of General and Physical Chemistry, University of Belgrade, Studentski trg 12-16, P. O. Box 137, 11001 Belgrade, Serbia. Electronic address: bojanjan@ffh.bg.ac.rs.
[Ti] Título:Distribution of apparent activation energy counterparts during thermo - And thermo-oxidative degradation of Aronia melanocarpa (black chokeberry).
[So] Source:Food Chem;230:30-39, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Kinetics of degradation for Aronia melanocarpa fresh fruits in argon and air atmospheres were investigated. The investigation was based on probability distributions of apparent activation energy of counterparts (ε ). Isoconversional analysis results indicated that the degradation process in an inert atmosphere was governed by decomposition reactions of esterified compounds. Also, based on same kinetics approach, it was assumed that in an air atmosphere, the primary compound in degradation pathways could be anthocyanins, which undergo rapid chemical reactions. A new model of reactivity demonstrated that, under inert atmospheres, expectation values for ε occured at levels of statistical probability. These values corresponded to decomposition processes in which polyphenolic compounds might be involved. ε values obeyed laws of binomial distribution. It was established that, for thermo-oxidative degradation, Poisson distribution represented a very successful approximation for ε values where there was additional mechanistic complexity and the binomial distribution was no longer valid.
[Mh] Termos MeSH primário: Antocianinas/química
Modelos Químicos
Photinia/química
[Mh] Termos MeSH secundário: Ar
Cinética
Oxirredução
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  7 / 164 MEDLINE  
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[PMID]:28399910
[Au] Autor:Lee HY; Weon JB; Ryu G; Yang WS; Kim NY; Kim MK; Ma CJ
[Ad] Endereço:Department of Food Science and Engineering, Seowon University, Cheongju, 361-742, Republic of Korea.
[Ti] Título:Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress in HT22 cells.
[So] Source:BMC Complement Altern Med;17(1):207, 2017 Apr 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glutamate (an endogenous excitatory neurotransmitter) at high concentrations contributes to the development of neurodegenerative diseases. Aronia melanocarpa (A. melanocarpa) berries contain anthocyanins and have high antioxidant activities. In this study, we evaluated whether A. melanocarpa berries could protect neuronal cells against glutamate-induced oxidative stress. METHOD: A. melanocarpa berries exerted a protective effect against cytotoxicity in HT22 mouse hippocampal cells by MTT assay. We evaluated oxidative stress parameters including ROS level, intracellular Ca level, glutathione level and antioxidant enzyme activity in HT22 cells to elucidate the mechanism of its neuroprotective effect. RESULTS: A. melanocarpa berries decreased glutamate-induced death of HT22 cells. In addition, A. melanocarpa berries reduced ROS and intracellular Ca levels. Glutathione level, antioxidant enzymes, glutathione reductase and glutathione peroxide activities and mitochondrial membrane potential were also increased in HT22 cells. CONCLUSION: These results suggested that A. melanocarpa berries protected HT22 cells by exerting an antioxidant effect.
[Mh] Termos MeSH primário: Ácido Glutâmico/efeitos adversos
Doenças Neurodegenerativas/metabolismo
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Photinia/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Frutas/química
Glutationa/metabolismo
Seres Humanos
Camundongos
Doenças Neurodegenerativas/tratamento farmacológico
Neurônios/metabolismo
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 3KX376GY7L (Glutamic Acid); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1716-1


  8 / 164 MEDLINE  
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[PMID]:28081181
[Au] Autor:Park CH; Kim JH; Lee EB; Hur W; Kwon OJ; Park HJ; Yoon SK
[Ad] Endereço:Division of Gastroenterology & Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
[Ti] Título:Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation.
[So] Source:PLoS One;12(1):e0169685, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis. Here, effects of Aronia melanocarpa (AM), known to be rich of anthocyanins, on hepatic lipid metabolism and adipogenic genes were determined. AM was treated to C57BL/6N mice fed with high fat diet (HFD) or to FL83B cells treated with free fatty acid (FFA). Changes in levels of lipids, enzymes and hormones were observed, and expressions of adipogenic genes involved in hepatic lipid metabolism were detected by PCR, Western blotting and luciferase assay. In mice, AM significantly reduced the body and liver weight, lipid accumulation in the liver, and levels of biochemical markers such as fatty acid synthase, hepatic triglyceride and leptin. Serum transaminases, indicators for hepatocyte injury, were also suppressed, while superoxide dismutase activity and liver antioxidant capacity were significantly increased. In FL83B cells, AM significantly reduced FFA-induced lipid droplet accumulation. Protein synthesis of an adipogenic transcription factor, peroxisome proliferator-activated receptor γ2 (PPARγ2) was inhibited in vivo. Furthermore, transcriptional activity of PPARγ2 was down-regulated in vitro, and mRNA expression of PPARγ2 and its downstream target genes, adipocyte protein 2 and lipoprotein lipase were down-regulated by AM both in vitro and in vivo. These results show beneficial effects of AM against hepatic lipid accumulation through the inhibition of PPARγ2 expression along with improvements in body weight, liver functions, lipid profiles and antioxidant capacity suggesting the potential therapeutic efficacy of AM on NAFLD.
[Mh] Termos MeSH primário: Regulação para Baixo/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
PPAR gama/genética
Photinia/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Linhagem Celular
Dieta Hiperlipídica
Ácidos Graxos não Esterificados/farmacologia
Leptina/análise
Leptina/sangue
Lipase Lipoproteica/genética
Lipase Lipoproteica/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
PPAR gama/antagonistas & inibidores
Photinia/metabolismo
Extratos Vegetais/química
Interferência de RNA
Superóxido Dismutase/metabolismo
Transaminases/sangue
Triglicerídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); 0 (Leptin); 0 (PPAR gamma); 0 (Plant Extracts); 0 (Triglycerides); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.- (Transaminases); EC 3.1.1.34 (Lipoprotein Lipase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169685


  9 / 164 MEDLINE  
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[PMID]:27992196
[Au] Autor:Wang B; Heinonen M
[Ad] Endereço:Department of Food and Environmental Sciences, Food Chemistry, University of Helsinki , P.O. Box 27, FI-00014 Helsinki, Finland.
[Ti] Título:Protein-Tannin Interactions of Tryptic Digests of α-Lactalbumin and Procyanidins.
[So] Source:J Agric Food Chem;65(1):148-155, 2017 Jan 11.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Protein-tannin interactions on a molecular level were investigated by using a model system containing peptides of α-lactalbumin and berry tannins (procyanidins). Oxidation of isolated tryptic peptide LDQWLCEK (m/z 1034) with procyanidin B2 or procyanidin fraction (PF) isolated from aronia juice was monitored by LC-ESI-MS. Procyanidin B2 and PF showed radical scavenging activities toward oxidation of the peptide with the peptide also preventing procyanidin B2 from degradation. Oxidation enhanced the cleavage of peptide between tryptophan and glutamine. Interaction products arising from WLCEK or WLCE residue and degradation product of procyanidin B2 were also identified using both size exclusion chromatography and LC-MS. Tryptophan and lysine were the amino acids most prone to interact with procyanidin B2. The study shows that protein-tannin interaction takes place during oxidation leading to both degradation of the parent compounds and formation of interaction products. This may in turn affect the quality of protein and tannin containing food.
[Mh] Termos MeSH primário: Biflavonoides/química
Catequina/química
Sucos de Frutas e Vegetais/análise
Lactalbumina/química
Photinia/química
Proantocianidinas/química
Taninos/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida de Alta Pressão
Proteínas na Dieta/química
Oxirredução
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Dietary Proteins); 0 (Proanthocyanidins); 0 (Tannins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); 9013-90-5 (Lactalbumin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04256


  10 / 164 MEDLINE  
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[PMID]:27737614
[Au] Autor:Xu YY; Qiu Y; Ren H; Ju DH; Jia HL
[Ad] Endereço:a Department of Food Science and Engineering, College of Food Science and Engineering , Jilin University , Changchun , China.
[Ti] Título:Optimization of ultrasound-assisted aqueous two-phase system extraction of polyphenolic compounds from Aronia melanocarpa pomace by response surface methodology.
[So] Source:Prep Biochem Biotechnol;47(3):312-321, 2017 Mar 16.
[Is] ISSN:1532-2297
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aronia melanocarpa berries are abundant in polyphenolic compounds. After juice production, the pomace of pressed berries still contains a substantial amount of polyphenolic compounds. For efficient utilization of A. melanocarpa berries and the enhancement of polyphenolic compound yields in Aronia melanocarpa pomace (AMP), total phenolics (TP) and total flavonoids (TF) from AMP were extracted, using ultrasound-assisted aqueous two-phase system (UAE-ATPS) extraction method. First, the influences of ammonium sulfate concentration, ethanol-water ratio, ultrasonic time, and ultrasonic power on TP and TF yields were investigated. On this basis, process variables such as ammonium sulfate concentration (0.30-0.35 g mL ), ethanol-water ratio (0.6-0.8), ultrasonic time (40-60 min), and ultrasonic power (175-225 W) were further optimized by implementing Box-Benhnken design with response surface methodology. The experimental results showed that optimal extraction conditions of TP from AMP were as follows: ammonium sulfate concentration of 0.324 g mL , ethanol-water ratio of 0.69, ultrasonic time of 52 min, and ultrasonic power of 200 W. Meanwhile, ammonium sulfate concentration of 0.320 g mL , ethanol-water ratio of 0.71, ultrasonic time of 50 min, and ultrasonic power of 200 W were determined as optimum extraction conditions of TF in AMP. Experimental validation was performed, where TP and TF yields reached 68.15 ± 1.04 and 11.67 ± 0.63 mg g , respectively. Close agreement was found between experimental and predicted values. Overall, the present results demonstrated that ultrasound-assisted aqueous two-phase system extraction method was successfully used to extract total phenolics and flavonoids in A. melanocarpa pomace.
[Mh] Termos MeSH primário: Fracionamento Químico/métodos
Flavonoides/isolamento & purificação
Photinia/química
Extratos Vegetais/química
Polifenóis/isolamento & purificação
Sonicação/métodos
[Mh] Termos MeSH secundário: Algoritmos
Sulfato de Amônio/química
Etanol/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 059QF0KO0R (Water); 3K9958V90M (Ethanol); SU46BAM238 (Ammonium Sulfate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1080/10826068.2016.1244684



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