Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.625.450 [Categoria DeCS]
Referências encontradas : 64 [refinar]
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[PMID]:28873649
[Au] Autor:Jakubíková M; Sádecká J; Kleinová A
[Ad] Endereço:Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic.
[Ti] Título:On the use of the fluorescence, ultraviolet-visible and near infrared spectroscopy with chemometrics for the discrimination between plum brandies of different varietal origins.
[So] Source:Food Chem;239:889-897, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper investigates the use of synchronous fluorescence, UV-Vis and near infrared (NIR) spectroscopy coupled with chemometric methods to discriminate samples of high-quality plum brandies (Slivovica) of different varietal origins (Prunus domestica L.). Synchronous fluorescence spectra (SFS) for wavelength differences in the range of 70-100nm, NIR spectra in the wavenumber range of 4000-7500cm and UV-Vis spectra in the wavelength interval of 220-320nm were compared. The best discrimination models were created by linear discriminant analysis based on principal component analysis applied to SFS recorded with wavelength difference either 80nm or 100nm, allowing the classification of plum brandy according to harvest time as early (summer) and late (autumn) plum varieties; the total correct classifications were 96% and 100% for the calibration and prediction steps, respectively.
[Mh] Termos MeSH primário: Prunus domestica
[Mh] Termos MeSH secundário: Bebidas Alcoólicas
Análise Discriminante
Análise de Componente Principal
Espectroscopia de Luz Próxima ao Infravermelho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28873545
[Au] Autor:Rahman MM; Abd El-Aty AM; Kabir MH; Chung HS; Lee HS; Hacimüftüoglu F; Jeong JH; Chang BJ; Shin HC; Shim JH
[Ad] Endereço:Natural Products Chemistry Lab., College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea.
[Ti] Título:A quick and effective methodology for analyzing dinotefuran and its highly polar metabolites in plum using liquid chromatography-tandem mass spectrometry.
[So] Source:Food Chem;239:1235-1243, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple and effective method was developed for analyzing dinotefuran and its three metabolites (MNG, UF, and DN) in plum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Due to the polarity and high water miscibility, dinotefuran and some of its metabolites (especially DN) have some limitations to be extracted with acetonitrile and salt following the "QuEChERS" sample preparation methodology. Alternatively, the samples were extracted with methanol, and purified with dispersive-solid phase extraction procedure (d-SPE) using primary secondary amine (PSA) and C sorbents after filtration, and mass up. Due to the suppression effect originated from plum matrix, matrix-matched calibration curves, which provided good linearity with coefficient of determination (R )≥0.998, were used for quantification of all analytes. Blank plum samples fortified with 2 spiking levels (10×LOQ and 50×LOQ) yielded satisfactory recoveries for all tested analytes in the range of 83.01 to 110.18% with relative standard deviation (RSD)≤8.91. The method was successfully applied to field-incurred plum samples and dinotefuran and all metabolites were positively detected and quantified. In conclusion, we suggest that the method can be expanded to polar compounds having solvent and partitioning problems in any of the versions of QuEChERS.
[Mh] Termos MeSH primário: Prunus domestica
[Mh] Termos MeSH secundário: Cromatografia Líquida
Guanidinas
Neonicotinoides
Nitrocompostos
Extração em Fase Sólida
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Guanidines); 0 (Neonicotinoids); 0 (Nitro Compounds); 1W509710WF (dinotefuran)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28535789
[Au] Autor:Islam NU; Amin R; Shahid M; Amin M; Zaib S; Iqbal J
[Ad] Endereço:Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, 25000, Pakistan. islanaz@yahoo.com.
[Ti] Título:A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.
[So] Source:BMC Complement Altern Med;17(1):276, 2017 May 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Phytotherapeutics exhibit diverse pharmacological effects that are based on the combined action of a mixture of phytoconstituents. In this study, Prunus domestica gum-loaded, stabilized gold and silver nanoparticles (Au/Ag-NPs) were evaluated for their prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory, and analgesic properties. METHODS: Au/Ag-NPs were biosynthesized and characterized with UV-Vis, FTIR, SEM, EDX, and XRD techniques. The effect of gum and metal ion concentration, reaction temperature, and time on the synthetic stability of nanoparticles was studied along with their post-synthetic stability against varying pH and salt concentrations, long-term storage and extremes of temperature. Nanoparticles were tested for anticancer (HeLa cervical cancer cells), antibacterial (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), urease inhibition (jack-bean urease), anti-inflammatory (carrageenan-induced paw edema), and antinociceptive (abdominal constriction response) activities. RESULTS: The nanoparticles were mostly spherical with an average particle size between 7 and 30 nm (Au-NPs) and 5-30 nm (Ag-NPs). Au/Ag-NPs maintained their colloidal stability and nanoscale characteristics against variations in physicochemical factors. Au/Ag-NPs have potent anticancer potential (IC = 2.14 ± 0.15 µg/mL and 3.45 ± 0.23 µg/mL). Au/Ag-NPs selectively suppressed the growth of S. aureus (10.5 ± 0.6 mm, 19.7 ± 0.4 mm), E. coli (10 ± 0.4 mm, 14.4 ± 0.7 mm), and P. aeruginosa (8.2 ± 0.3 mm, 13.1 ± 0.2 mm), as well as showed preferential inhibition against jack-bean urease (19.2 ± 0.86%, 21.5 ± 1.17%). At doses of 40 and 80 mg/kg, Au-NPs significantly ameliorated the increase in paw edema during the 1st h (P < 0.05, P < 0.01) and 2-5 h (P < 0.001) of carrageenan-induced inflammation compared to the 200 and 400 mg/kg doses of P. domestica gum (P < 0.05, P < 0.001). At similar doses, Au-NPs also significantly abolished (P < 0.01) the tonic visceral, chemically-induced nociception, which was comparable to that of P. domestica gum (200 mg/kg; P < 0.05, 400 mg/kg; P < 0.01).
[Mh] Termos MeSH primário: Analgésicos/química
Antibacterianos/química
Anti-Inflamatórios/química
Inibidores Enzimáticos/química
Extratos Vegetais/administração & dosagem
Gomas Vegetais/administração & dosagem
Prunus domestica/química
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Analgésicos/síntese química
Animais
Antibacterianos/administração & dosagem
Antibacterianos/síntese química
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/síntese química
Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral
Edema/tratamento farmacológico
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/síntese química
Feminino
Ouro/administração & dosagem
Ouro/química
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Nanopartículas/administração & dosagem
Nanopartículas/química
Extratos Vegetais/química
Gomas Vegetais/química
Prata/administração & dosagem
Prata/química
Urease/antagonistas & inibidores
Urease/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (Plant Gums); 3M4G523W1G (Silver); 7440-57-5 (Gold); EC 3.5.1.5 (Urease)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1791-3


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[PMID]:28445075
[Au] Autor:Delgado Cuenca P; Almaiman L; Schenk S; Kern M; Hooshmand S
[Ad] Endereço:1 School of Exercise and Nutritional Sciences, San Diego State University , San Diego, California, USA.
[Ti] Título:Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum.
[So] Source:J Med Food;20(7):653-658, 2017 Jul.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In cell culture studies, dried plum (Prunus domestica L.) polyphenols increased osteoblast alkaline phosphatase (ALP) activity, mineralized nodule formation, and the expression of the bone marker genes runt-related transcription factor 2 (RUNX2) and osterix. The purpose of this study was to determine whether human serum collected 1 and 2 h after dried plum ingestion influenced osteoblast cell activity and gene expression. Five healthy women ingested 100 g of dried plum, and serum samples were collected at baseline (before dried plum ingestion) and 1 and 2 h postingestion of dried plum. MC3T3-E1 osteoblast cells were treated (2% of medium) with these serum samples for 3 or 9 days. Intracellular and extracellular ALP activities were significantly increased after 3 or 9 days of treatment with serum both postingestion time points, with no effect seen in baseline samples. Also, serum obtained 1 and 2 h postingestion significantly increased the mRNA expression of bone markers RUNX2 and connexin43 (CX43) after both 3 and 9 days of incubation periods. Finally, serum obtained 1 and 2 h postingestion increased the mRNA expression of ß-catenin after 9 days of incubation. We conclude that osteoblast activity and function are increased by dried plum ingestion, which may, in part, explain its beneficial effects on bone health.
[Mh] Termos MeSH primário: Diferenciação Celular
Osteoblastos/citologia
Pré-Menopausa/metabolismo
Prunus domestica/metabolismo
[Mh] Termos MeSH secundário: Adulto
Fosfatase Alcalina/metabolismo
Animais
Conexina 43/genética
Conexina 43/metabolismo
Subunidade alfa 1 de Fator de Ligação ao Core/sangue
Feminino
Seres Humanos
Camundongos
Osteoblastos/enzimologia
Osteoblastos/metabolismo
Pré-Menopausa/sangue
Fator de Transcrição Sp7
Fatores de Transcrição/sangue
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexin 43); 0 (Core Binding Factor Alpha 1 Subunit); 0 (Sp7 Transcription Factor); 0 (Sp7 protein, human); 0 (Transcription Factors); 0 (beta Catenin); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0158


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[PMID]:28422064
[Au] Autor:Wallace TC
[Ad] Endereço:Department of Nutrition and Food Studies, George Mason University, Fairfax, VA 22030, USA. taylor.wallace@me.com.
[Ti] Título:Dried Plums, Prunes and Bone Health: A Comprehensive Review.
[So] Source:Nutrients;9(4), 2017 Apr 19.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The 2015-2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.
[Mh] Termos MeSH primário: Densidade Óssea
Osso e Ossos/fisiologia
Dieta
Frutas
Prunus domestica
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Bases de Dados Factuais
Modelos Animais de Doenças
Feminino
Seres Humanos
Osteoblastos/citologia
Osteoclastos/citologia
Osteoporose/prevenção & controle
Osteoporose Pós-Menopausa/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:28334322
[Au] Autor:Rosa JMD; Arioli CJ; Santos JPD; Menezes-Netto AC; Botton M
[Ad] Endereço:Universidade do Estado de Santa Catarina, Laboratório de Entomologia, Lages, SC 88520-000, Brazil ( joatanmachado@gmail.com ).
[Ti] Título:Evaluation of Food Lures for Capture and Monitoring of Anastrepha fraterculus (Diptera: Tephritidae) on Temperate Fruit Trees.
[So] Source:J Econ Entomol;110(3):995-1001, 2017 Jun 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae) is the main pest of fruit trees grown in temperate climates in the southern region of Brazil. The objective of this work was to evaluate the efficiency of the major commercial food lures used in Brazil for trapping and monitoring of A. fraterculus in plum, pear, and feijoa orchards. The assessed lures were hydrolyzed proteins of animal origin (CeraTrap) and plant origin (BioAnastrepha), torula yeast + borax (Torula), and grape juice. Response variables included the rate of adult capture (flies per trap per day, FTD) and the percentage of females captured. We also evaluated the number of times the weekly capture rate exceeded the traditional threshold of 0.5 FTD for each lure. Traps baited with grape juice, currently used for monitoring A. fraterculus in Southern Brazil, captured fewer adults and a lower percentage of females compared with the other lures. CeraTrap trapped a greater number of A. fraterculus adults and, in some cases, a lower percentage of females compared with the other lures in pears. Traps baited with CeraTrap had greater capture rates (FTD), particularly during the stages of fruit maturation and harvest, and even in years with low population density of A. fraterculus, thus demonstrating greater sensitivity in the detection of this pest. These results show that, in order to detect and monitor the presence of A. fraterculus in plum, feijoa, and pear crops, protein-based lures are superior to grape juice, especially the animal protein CeraTrap.
[Mh] Termos MeSH primário: Quimiotaxia
Controle de Insetos/métodos
Feromônios/farmacologia
Tephritidae/fisiologia
[Mh] Termos MeSH secundário: Animais
Brasil
Feijoa/crescimento & desenvolvimento
Feminino
Masculino
Odorantes/análise
Prunus domestica/crescimento & desenvolvimento
Pyrus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pheromones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox084


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[PMID]:28288933
[Au] Autor:Haddadi-Guemghar H; Tlili A; Dairou J; Paul JL; Madani K; Janel N
[Ad] Endereço:Laboratoire de Biomathématiques, Biophysique, Biochimie, et Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia, Algeria.
[Ti] Título:Effect of lyophilized prune extract on hyperhomocysteinemia in mice.
[So] Source:Food Chem Toxicol;103:183-187, 2017 May.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Altered homocysteine metabolism defined as hyperhomocysteinemia is implicated as pathogenic factor in several cardiovascular diseases and atherosclerosis. The purpose of this study was to investigate the efficacy of prune extract, a good source of phenolic antioxidants, on lowering plasma homocysteine level in male hyperhomocysteinemic mice from average weight of 28 g. The administration of lyophilized prune extract was carried out by intraperitoneal injection one day preceding and one hour before sacrifice of mice. Prune extract decreased significantly plasma homocysteine level, correlated with an increased activity of S-adenosylhomocysteine (SAH) hydrolase and NAD(P)H: quinone oxydoreductase-1 activities. Our results suggest a beneficial effect of prune extract on hyperhomocysteinemia with reduction of homocysteine level by its conversion on to SAH by S-adenosylhomocysteine hydrolase, which is activated by NAD , a by-product of NAD(P)H: quinone oxydo reductase-1.
[Mh] Termos MeSH primário: Hiper-Homocisteinemia/dietoterapia
Extratos Vegetais/farmacologia
Prunus domestica/química
[Mh] Termos MeSH secundário: Adenosil-Homocisteinase/metabolismo
Animais
Ácido Clorogênico/farmacologia
Cistationina beta-Sintase/genética
Feminino
Liofilização
Homocisteína/sangue
Hiper-Homocisteinemia/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Camundongos Mutantes
NAD(P)H Desidrogenase (Quinona)/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0LVT1QZ0BA (Homocysteine); 318ADP12RI (Chlorogenic Acid); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (Nqo1 protein, mouse); EC 3.3.1.1 (Adenosylhomocysteinase); EC 4.2.1.22 (Cystathionine beta-Synthase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28202328
[Au] Autor:Tomohara K; Ito T; Onikata S; Kato A; Adachi I
[Ad] Endereço:Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: tomohara@med.u-toyama.ac.jp.
[Ti] Título:Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions.
[So] Source:Bioorg Med Chem Lett;27(7):1620-1623, 2017 04 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study discovered four novel hyaluronan-degrading enzyme (hyaluronidase) inhibitors including chikusetsusaponins and catechins through the activity-guided separation of Panax japonicus and Prunus salicina, respectively. Although the discovery resulted in identification of usual frequent hitters, subsequent mechanistic characterizations under our DMSO-perturbed assay conditions and related protocols revealed that chikusetusaponin IV would serve as an aggregating and non-specific binding inhibitor, while (-)-epicatechin would interact specifically with enzyme at the catalytic site or more likely at a kind of catechin-binding site with a relatively week inhibitory activity. The latter description might provide a possible explanation for the well-known fact that a series of catechin have been described as frequent hitters in biological assays with a moderate activity. Thus, the present study demonstrated a practical and robust methodology to characterize initial screening hits mechanistically molecule-by-molecule in the early stage of natural product-based drug discovery.
[Mh] Termos MeSH primário: Dimetil Sulfóxido/química
Inibidores Enzimáticos/química
Hialuronoglucosaminidase/antagonistas & inibidores
Panax/química
Prunus domestica/química
Saponinas/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Catequina/química
Bovinos
Descoberta de Drogas
Ensaios Enzimáticos
Inibidores Enzimáticos/isolamento & purificação
Ácido Glicirrízico/química
Hialuronoglucosaminidase/química
Masculino
Octoxinol/química
Extratos Vegetais/farmacologia
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (Saponins); 0 (chikusetsusaponin IV); 0 (chikusetsusaponin V); 6FO62043WK (Glycyrrhizic Acid); 8R1V1STN48 (Catechin); 9002-93-1 (Octoxynol); EC 3.2.1.35 (Hyaluronoglucosaminidase); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


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[PMID]:28164731
[Au] Autor:Chiu HF; Huang YC; Lu YY; Han YC; Shen YC; Golovinskaia O; Venkatakrishnan K; Wang CK
[Ad] Endereço:a Department of Chinese Medicine , Taichung Hospital, Ministry of Health and Well-being , Taichung , Taiwan , ROC.
[Ti] Título:Regulatory/modulatory effect of prune essence concentrate on intestinal function and blood lipids.
[So] Source:Pharm Biol;55(1):974-979, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Prunus domestica Linn (Rosaceae) has been considered a functional food, owing to its various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic and anticancer. OBJECTIVE: This placebo-controlled, randomized study was framed to check the beneficial activity of prune essence concentrates (PEC) in corroboration with intestinal function and lipid profile in mildly hypercholesterolemic subjects. MATERIALS AND METHODS: Sixty healthy mild hypercholesterolemic subjects were randomly chosen and segregated into three groups as placebo (consume 50 mL of simulated prune drink), PEC I (consume 50 mL of PEC/day) and PEC II (consume 100 mL of PEC/day) for 4 weeks with 2 weeks of follow-up without PEC consumption. RESULTS: Intake of PEC (I and II) for 4 weeks substantially ameliorated (p < 0.05) the colony number of Bifidobacterium spp. (1.18- and 1.19-fold) and Lactobacillus spp. (1.07- and 1.16-fold), but markedly lowered (p < 0.05) the colony number of Clostridium perfringens (5.97 and 8.35%) and Escherichia coli (6.25 and 9.38%). Meanwhile, the total cholesterol (TC; 5.90 and 6.99%) levels and LDL-c (6.68 and 6.53%) were significantly reduced (p < 0.05), but no change in other lipid parameters. Whereas, the antioxidant capacity was also concomitantly elevated (p < 0.05) upon administration with PEC. DISCUSSION AND CONCLUSION: Overall, the results suggest that the use of PEC may positively regulate the intestinal microflora and thereby effectively lower the TC levels and thus act as a hypocholesterolemic agent.
[Mh] Termos MeSH primário: Anticolesterolemiantes/uso terapêutico
LDL-Colesterol/sangue
Sucos de Frutas e Vegetais
Fármacos Gastrointestinais/uso terapêutico
Microbioma Gastrointestinal/efeitos dos fármacos
Hipercolesterolemia/tratamento farmacológico
Intestinos/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Prunus domestica/química
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticolesterolemiantes/isolamento & purificação
Antioxidantes/isolamento & purificação
Antioxidantes/uso terapêutico
Biomarcadores/sangue
Contagem de Colônia Microbiana
Regulação para Baixo
Fezes/microbiologia
Feminino
Fármacos Gastrointestinais/isolamento & purificação
Seres Humanos
Hipercolesterolemia/sangue
Hipercolesterolemia/diagnóstico
Intestinos/microbiologia
Masculino
Meia-Idade
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Índice de Gravidade de Doença
Taiwan
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Cholesterol, LDL); 0 (Gastrointestinal Agents); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1285323


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[PMID]:28106740
[Au] Autor:Michalska A; Wojdylo A; Lysiak GP; Figiel A
[Ad] Endereço:Institute of Agricultural Engineering, Wroclaw University of Environmental and Life Sciences, 51-630 Wroclaw, Poland. anna.michalska@up.wroc.pl.
[Ti] Título:Chemical Composition and Antioxidant Properties of Powders Obtained from Different Plum Juice Formulations.
[So] Source:Int J Mol Sci;18(1), 2017 Jan 17.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Among popular crops, plum ( L.) has received special attention due to its health-promoting properties. The seasonality of this fruit makes it impossible to consume it throughout the year, so new products in a powder form may offer an alternative to fresh consumption and may be used as high-quality natural food ingredients. A 100% plum (cultivar "Valor") juice was mixed with three different concentrations of maltodextrin or subjected to sugars removal by amberlite-XAD column, and dried using the freeze, spray, and vacuum (40, 60, and 80 °C) drying techniques. The identification and quantification of phenolic acids, flavonols, and anthocyanins in plum powders was performed by LC-MS QTof and UPLC-PDA, respectively. l-ascorbic acid, hydroxymethylfurfural, and antioxidant capacity were measured by the Trolox equivalent antioxidant capacity (TEAC) ABTS and ferric reducing antioxidant potential (FRAP) methods in order to compare the influence of the drying methods on product quality. The results indicated that the profile of polyphenolic compounds in the plum juice powders significantly differed from the whole plum powders. The drying of a sugar free plum extract resulted in higher content of polyphenolic compounds, l-ascorbic acid and antioxidant capacity, but lower content of hydroxymethylfurfural, regardless of drying method applied. Thus, the formulation of plum juice before drying and the drying method should be carefully selected in order to obtain high-quality powders.
[Mh] Termos MeSH primário: Antioxidantes/química
Sucos de Frutas e Vegetais/análise
Pós/química
Prunus domestica/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Ácido Ascórbico/análise
Cromatografia Líquida/métodos
Dessecação/métodos
Flavonóis/análise
Frutas/química
Furaldeído/análogos & derivados
Furaldeído/análise
Espectrometria de Massas/métodos
Fenóis/análise
Extratos Vegetais/química
Polifenóis/análise
Pós/normas
Controle de Qualidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Flavonols); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols); 0 (Powders); 70ETD81LF0 (5-hydroxymethylfurfural); DJ1HGI319P (Furaldehyde); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE



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