Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.750 [Categoria DeCS]
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[PMID]:29424213
[Au] Autor:Malysheva AG; Rakhmanin YA; Rastyannikov EG; Kozlova NY; Artyushina IY; Shokhin VA
[Ti] Título:[Gas chromatography-mass spectrometric studies of volatile emissions from plants for the assessment of the effectiveness and chemical safety of the implementation of environment improving phytotechnologies].
[So] Source:Gig Sanit;95(6):501-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The chromato-mass-spectrometric studies of volatile emissions of fresh-cut roses have revealed the persistence of wide range of organic compounds. The most large content was consist of terpene hydrocarbons. The contribution of oxygen-containing components (alcohols, ethers, aldehydes and ketones) varied in wide ranges in dependence on the content of the feeding solution. The significant part of plants ' volatiles has no hygienic norm. Among the substances released into the air space ofpremises with volatile emissions ofplants, a significant part has not hygienic standards. Purposeful change in composition of the mixture of volatile organic compounds released by the plants, in the combination with chemical-analytical control of the content of these substances by gas chromatography-mass spectrometry in terms of ecological and hygienic aspects may be useful in the development, use and determination of the optimal conditions of the implementation of environment improving phytotechnologies and evaluation of the efficacy and safety of their impact on public health.
[Mh] Termos MeSH primário: Agroquímicos
Exposição Ambiental
Cromatografia Gasosa-Espectrometria de Massas/métodos
Rosa
Compostos Orgânicos Voláteis
[Mh] Termos MeSH secundário: Agroquímicos/efeitos adversos
Agroquímicos/análise
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Monitoramento Ambiental/métodos
Fertilizantes/efeitos adversos
Fertilizantes/análise
Seres Humanos
Compostos Orgânicos/efeitos adversos
Compostos Orgânicos/análise
Federação Russa/epidemiologia
Compostos Orgânicos Voláteis/efeitos adversos
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Fertilizers); 0 (Organic Chemicals); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:27773731
[Au] Autor:Dadras H; Hayatbakhsh MR; Shelton WL; Golpour A
[Ad] Endereço:University of South Bohemia in Ceské Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátisí 728/II, 389 25, Vodnany, Czech Republic. Electronic address: dadras@frov.jcu.cz.
[Ti] Título:Effects of dietary administration of Rose hip and Safflower on growth performance, haematological, biochemical parameters and innate immune response of Beluga, Huso huso (Linnaeus, 1758).
[So] Source:Fish Shellfish Immunol;59:109-114, 2016 Dec.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate effects of two dietary medicinal herbs, Rose hip (Rosa canina) and Safflower (Carthamus tinctorius) supplementation on growth performance, haematological, biochemical parameters and innate immune response of in juvenile beluga, Huso huso. Fish (26.3 ± 0.4 g) were allocated into 15 tanks (20 fish per tank) and triplicate groups were fed a control diet or diets containing 1% and 2% of medicinal herbs, respectively. Feed conversion ratio (FCR), specific growth rate (SGR) and condition factor (CF) did not show significant differences (P > 0.05) in fish given herbal diets. Significant differences were observed in number of white blood cells (WBC) and haemoglobin (Hb) values among the dietary treatments. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly lower in supplemented diet groups compared with the control. Innate immune responses (lysozyme activity and ACH ) were significantly higher in 2% Safflower-fed fish compared with other groups (P < 0.05). These results indicate that medicinal herbs in diets can be considered as a beneficial dietary supplement for improving the physiological parameters and enhance the immune response of Persian sturgeon.
[Mh] Termos MeSH primário: Carthamus tinctorius/imunologia
Suplementos Nutricionais
Imunidade Inata
Rosa/imunologia
Salmonidae/imunologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Análise Química do Sangue/veterinária
Carthamus tinctorius/química
Dieta/veterinária
Testes Hematológicos/veterinária
Plantas Medicinais/química
Plantas Medicinais/imunologia
Rosa/química
Salmonidae/sangue
Salmonidae/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171203
[Lr] Data última revisão:
171203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:28851456
[Au] Autor:Moein E; Hajimehdipoor H; Toliyat T; Choopani R; Hamzeloo-Moghadam M
[Ad] Endereço:Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method.
[So] Source:Daru;25(1):19, 2017 Aug 29.
[Is] ISSN:2008-2231
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Currently, people are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. In the present investigation, a poly herbal medicine "Ayarij-e-Faiqra" (AF) based on Iranian traditional medicine (ITM) has been formulated and its quality control parameters have been developed. METHODS: The main ingredients of AF including barks of Cinnamomum zeylanicum Blume and Cinnamomum cassia J. Presl, the rhizomes of Nardostachys jatamansi DC., the fruits of Piper cubeba L.f., the flowers of Rosa damascena Herrm., the oleo gum resin of Pistacia terebinthus L. and Aloe spp. dried juice were powdered and used for preparing seven tablet formulations of the herbal mixture. Flowability of the different formulated powders was examined and the best formulations were selected (F6&F7). The tablets were prepared from the selected formulations compared according to the physical characteristics and finally, F7 was selected and coated. Physicochemical characters of core and coated AF tablets were determined and the HPLC method for quantitation of aloin as a marker of tablets was selected and verified according to selectivity, linearity, precision, recovery, LOD and LOQ. RESULTS: The results showed that core and coated AF tablets were in agreement with USP requirements for herbal drugs. They had acceptable appearance, disintegration time, friability, hardness, dissolution behavior, weight variation and content uniformity. The amount of aloin in tablets was found 123.1 mg/tab. The HPLC method for aloin determination in AF tablets was verified according to selectivity, linearity (5-500 µg/ml, r :0.9999), precision (RSD: 1.62%), recovery (108.0%), LOD & LOQ (0.0053 & 0.0161 µg/ml). CONCLUSIONS: The formulated tablets could be a good substitute for powder and capsules of AF in ITM clinics with a feasible and precise method for its quality control. Ayarij-e-Faiqra formulation.
[Mh] Termos MeSH primário: Aloe
Medicina Tradicional
Fitoterapia
[Mh] Termos MeSH secundário: Cinnamomum
Composição de Medicamentos
Emodina/análogos & derivados
Emodina/análise
Emodina/uso terapêutico
Flores
Frutas
Medicina Herbária/métodos
Irã (Geográfico)
Medicina Tradicional/métodos
Nardostachys
Fitoterapia/métodos
Piper
Pistacia
Casca de Planta
Rizoma
Rosa
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tablets); KA46RNI6HN (Emodin); W41H6S09F4 (alloin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1186/s40199-017-0185-x


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[PMID]:28573216
[Au] Autor:Jemaa HB; Jemia AB; Khlifi S; Ahmed HB; Slama FB; Benzarti A; Elati J; Aouidet A
[Ad] Endereço:Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.
[Ti] Título:ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF L.
[So] Source:Afr J Tradit Complement Altern Med;14(2):1-8, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus is one of the most common endocrinal disorders and medicinal plants continue to play an important role in the management of this disease. In this study, was investigated for the antioxidant and α-amylase inhibition activities. MATERIALS AND METHODS: Methanolic extract of was investigated for its potential antioxidant activity. The extracts' total phenolic and flavonoid contents and scavenging capacity for free radicals were evaluated. The α-amylase inhibition assay was also carried. RESULTS: extract exhibits a total Phenolic and flavonoid levels respectively (21.918 mg GAE/g and 2.647mg ER/g). The free radical scavenging activity was found to be prominent against DPPH with an IC50 of 0.668 mg/ml and against ABTS with an IC50 of 0.467 mg/ml. Extract showed a significant ferric ion reducing activities with an IC50 of4.962 mg/ml. CONCLUSION: exerted a higher inhibitory activity against α-amylase. The obtained results support the antidiabetic use of .
[Mh] Termos MeSH primário: Amilases/antagonistas & inibidores
Antioxidantes/farmacologia
Flavonoides/farmacologia
Hipoglicemiantes/farmacologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Rosa/química
[Mh] Termos MeSH secundário: Benzotiazóis/metabolismo
Compostos de Bifenilo/metabolismo
Diabetes Mellitus/enzimologia
Flavonoides/análise
Fenóis/análise
Picratos/metabolismo
Extratos Vegetais/química
Ácidos Sulfônicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 3.2.1.- (Amylases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.1


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[PMID]:28554620
[Au] Autor:Elmastas M; Demir A; Genç N; Dölek Ü; Günes M
[Ad] Endereço:Department of Chemistry, Faculty of Science and Arts, Gaziosmanpasa University, Tokat, Turkey. Electronic address: mahfuz.elmastas@gop.edu.tr.
[Ti] Título:Changes in flavonoid and phenolic acid contents in some Rosa species during ripening.
[So] Source:Food Chem;235:154-159, 2017 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, fruits of Rosa dumalis, R. canina, and R. villosa were cultivated and harvested at six different time points based on colour changes during the ripening period. Phenolic acid and flavonoid contents in fresh hypanthium were determined by HPLC-DAD. Derivatives of organic acid (gallic, caffeic, p-coumaric, and ferulic acids) and flavonoid (catechin, eriocitrin, rutin, apigenin, quercetin, apigenin-7-O-glucoside and kaempferol) were quantified using calibration curves. Phenolic acid contents of the Rosa species increased nonlinearly depending on the harvesting time. The highest amount of catechin was found at the fifth harvest time point (H-5) ranged from 323 to 472mgkg . The highest level of caffeic acid content was found in the R. dumalis ranged from 24 to 77mgkg . The total amount of flavonoid increased up to the fifth harvest time point (H-5), whereas the amount of total phenolic acid tended to decrease until the same harvest period.
[Mh] Termos MeSH primário: Flavonoides/análise
Fenóis/análise
Rosa/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Quercetina
Rutina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phenols); 5G06TVY3R7 (Rutin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28542547
[Au] Autor:Franco-Hermida JJ; Quintero MF; Cabrera RI; Guzman JM
[Ad] Endereço:Technical Department, G.R. Chía S.A., Centro Empresarial Chía, Chía, Colombia.
[Ti] Título:Determination of diagnostic standards on saturated soil extracts for cut roses grown in greenhouses.
[So] Source:PLoS One;12(5):e0178500, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This work comprises the theoretical determination and validation of diagnostic standards for the analysis of saturated soil extracts for cut rose flower crops (Rosa spp.) growing in the Bogota Plateau, Colombia. The data included 684 plant tissue analyses and 684 corresponding analyses of saturated soil extracts, all collected between January 2009 and June 2013. The tissue and soil samples were selected from 13 rose farms, and from cultivars grafted on the 'Natal Briar' rootstock. These concurrent samples of soil and plant tissues represented 251 production units (locations) of approximately 10,000 m2 distributed across the study area. The standards were conceived as a tool to improve the nutritional balance in the leaf tissue of rose plants and thereby define the norms for expressing optimum productive potential relative to nutritional conditions in the soil. To this end, previously determined diagnostic standard for rose leaf tissues were employed to obtain rates of foliar nutritional balance at each analyzed location and as criteria for determining the diagnostic norms for saturated soil extracts. Implementing this methodology to foliar analysis, showed a higher significant correlation for diagnostic indices. A similar behavior was observed in saturated soil extracts analysis, becoming a powerful tool for integrated nutritional diagnosis. Leaf analyses determine the most limiting nutrients for high yield and analyses of saturated soil extracts facilitate the possibility of correcting the fertigation formulations applied to soils or substrates. Recommendations are proposed to improve the balance in soil-plant system with which the possibility of yield increase becomes more probable. The main recommendations to increase and improve rose crop flower yields would be: continuously check pH values of SSE, reduce the amounts of P, Fe, Zn and Cu in fertigation solutions and carefully analyze the situation of Mn in the soil-plant system.
[Mh] Termos MeSH primário: Flores/crescimento & desenvolvimento
Flores/fisiologia
Rosa/crescimento & desenvolvimento
Rosa/fisiologia
[Mh] Termos MeSH secundário: Produtos Agrícolas/crescimento & desenvolvimento
Produtos Agrícolas/fisiologia
Concentração de Íons de Hidrogênio
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/fisiologia
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178500


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[PMID]:28477005
[Au] Autor:Tiwari N; Pandit R; Gaikwad S; Gade A; Rai M
[Ad] Endereço:Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
[Ti] Título:Biosynthesis of zinc oxide nanoparticles by petals extract of L., its formulation as nail paint and evaluation of antifungal activity against fungi causing onychomycosis.
[So] Source:IET Nanobiotechnol;11(2):205-211, 2017 Mar.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of L. (rose). Its efficacy was evaluated against two dermatophytes: namely: and which cause onychomycosis. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with ZnO-NPs. The synthesised ZnO-NPs were preliminary detected by using ultraviolet UV visible spectroscopy, which showed specific absorbance. The ZnO-NPs were further characterised by nanoparticle tracking analysis (NTA), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction and Zetasizer. Moreover, nanoparticles containing nail paint (nanopaint) was formulated and its antifungal activity was also assessed against and . ZnO-NPs and formulated nanopaint containing ZnO-NPs, both showed significant antifungal activity. The maximum activity was noted against and lesser against Minimum inhibitory concentration of ZnO-NPs was also determined against the dermatophytes causing onychomycosis infection. ZnO-NPs can be utilised as a potential antifungal agent for the treatment of onychomycosis after more experimental trials.
[Mh] Termos MeSH primário: Flores/química
Fungos/efeitos dos fármacos
Nanopartículas Metálicas/administração & dosagem
Onicomicose/microbiologia
Extratos Vegetais/química
Rosa/química
Óxido de Zinco/administração & dosagem
[Mh] Termos MeSH secundário: Antifúngicos
Produtos Biológicos
Sobrevivência Celular/efeitos dos fármacos
Cosméticos/administração & dosagem
Cosméticos/síntese química
Cosméticos/metabolismo
Relação Dose-Resposta a Droga
Composição de Medicamentos
Fungos/fisiologia
Seres Humanos
Teste de Materiais
Nanopartículas Metálicas/ultraestrutura
Unhas
Onicomicose/tratamento farmacológico
Onicomicose/patologia
Pintura
Tamanho da Partícula
Extratos Vegetais/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Biological Products); 0 (Cosmetics); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0003


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[PMID]:28402181
[Au] Autor:Jiménez S; Jiménez-Moreno N; Luquin A; Laguna M; Rodríguez-Yoldi MJ; Ancín-Azpilicueta C
[Ad] Endereço:a Departamento de Química Aplicada , Universidad Pública de Navarra , Pamplona , Spain.
[Ti] Título:Chemical composition of rosehips from different Rosa species: an alternative source of antioxidants for the food industry.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(7):1121-1130, 2017 Jul.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It is important to explore new sources of natural additives because the demand for these compounds by consumers is increasing. These products also provide health benefits and help in food preservation. An unexplored source of nutrients and antioxidant compounds is rosehip, the fleshy fruit of roses. This work compares the antioxidant compound (vitamin C, neutral phenols and acidic phenols) content of four Rosa species rosehips: R. pouzinii, R. corymbifera, R. glauca and R. canina from different geographical zones. Results show quantitative variability in ascorbic acids and neutral phenols content, and quantitative and qualitative differences in acidic phenol content, depending on species. Vitamin C concentration was highly variable depending on species, R. canina being the one with the highest concentration and R. pouzinii the one with the lowest content. Variability was found in total neutral polyphenols concentration and a correlation between freshness of the rosehips and concentration of neutral polyphenols was also found. Significant differences were found in the acidic phenols content among the studied species. Generally antioxidant activity was higher in the vitamin C fraction.
[Mh] Termos MeSH primário: Antioxidantes/isolamento & purificação
Indústria Alimentícia
Rosa/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2017.1319071


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[PMID]:28346355
[Au] Autor:Luo H; Deng S; Fu W; Zhang X; Zhang X; Zhang Z; Pang X
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China. hhluo@stu.scau.edu.cn.
[Ti] Título:Characterization of Active Anthocyanin Degradation in the Petals of Rosa chinensis and Brunfelsia calycina Reveals the Effect of Gallated Catechins on Pigment Maintenance.
[So] Source:Int J Mol Sci;18(4), 2017 Mar 25.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Anthocyanin degradation decreases ornamental or nutritional values of horticultural products. To investigate factors that may influence colour change in flower development, anthocyanin degradation was compared between the flowers of and , which show rapid and slow degradation, respectively. In-gel activity assays, high performance liquid chromatography (HPLC) analysis of tannins, enzyme kinetics measurement and immune-detection of anthocyanin degradation related-perioxidases (PODs) were carried out for the comparison. Rose petals possessed significantly lower anthocyanin degradation-related POD activities than petals, which may be related to the high tannin contents. Epicatechin gallate (ECG) and gallocatechin gallate (GCG) were detected in rose as 161.3 ± 12.34 and 273.56 ± 41.23 µg/g FW (Fresh Weight) respectively, while not detected in . ECG and GCG inhibited the activities of the POD with half maximal inhibitory concentrations (IC50s) as 21.5 and 29.7 µM respectively, and increased the colour intensities of the anthocyanins. Catechin and epicatechin did not inhibit the POD activity, while serving as POD substrates, with m (the Michaelis constant) as 0.48 and 1.23 mM. Similar protein levels of the anthocyanin degradation-related 40-kDa PODs were detected in and rose. In summary, high amount of tannins, particularly ECG and GCG, in red rose petals may inhibit the degradation-related enzymes, leading to the maintenance of anthocyanins in vivo.
[Mh] Termos MeSH primário: Antocianinas/metabolismo
Catequina/análogos & derivados
Rosa/metabolismo
Solanaceae/metabolismo
[Mh] Termos MeSH secundário: Catequina/metabolismo
Flores/metabolismo
Peroxidases/metabolismo
Proteínas de Plantas/metabolismo
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Plant Proteins); 0 (epicatechin 5-gallate); 0 (gallocatechin-7-gallate); 8R1V1STN48 (Catechin); EC 1.11.1.- (Peroxidases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170507
[Lr] Data última revisão:
170507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28298541
[Au] Autor:González-Mañán D; D'Espessailles A; Dossi CG; San Martín M; Mancilla RA; Tapia GS
[Ad] Endereço:Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; and.
[Ti] Título:Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-α and NRF2 in C57BL/6J Mice Fed a High-Fat Diet.
[So] Source:J Nutr;147(4):579-588, 2017 Apr.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rosa mosqueta (RM) oil is characterized by high concentrations of antioxidants and α-linolenic acid (ALA; 18:3n-3). We have previously demonstrated in male C57BL/6J mice that RM decreases hepatic steatosis, a condition strongly associated with oxidative stress and inflammation. We studied the molecular mechanisms that underlie the role of RM in preventing high-fat diet (HFD)-induced oxidative stress and inflammation. Male C57BL/6J mice aged 28 d and weighing 12-14 g were divided into the following groups and fed for 12 wk: control diet (CD; 10% fat, 20% protein, and 70% carbohydrates); CD + RM (1.94 mg ALA â‹… g body weight â‹… d administered by oral gavage); HFD (60% fat, 20% protein, and 20% carbohydrates); and HFD + RM. General parameters (body weight, visceral fat, and histology); glucose metabolism [homeostasis model assessment and blood glucose area under the curve (AUC)]; oxidative stress [hepatic nuclear factor (erythroid-derived 2)-like-2 (NRF2) and heme oxygenase 1 (HO-1) concentrations]; and inflammation [hepatic peroxisome proliferator-activated receptor α (PPAR-α) and acyl-coenzyme A oxidase 1 (ACOX1) concentrations, blood tumor necrosis factor α (TNF-α) and interleukin 1ß (IL-1ß) concentrations, and and mRNA expression in liver and visceral adipose tissue] were evaluated. In the HFD + RM mice, the final body weight (24.8 ± 1.1 g) was 19% lower than in the HFD mice (30.6 ± 2.8 g) ( < 0.05). Visceral fat was 34% lower in the HFD + RM mice than in the HFD mice ( < 0.05). The blood glucose AUC was 29% lower and and expression levels were 47% and 59% lower, respectively, in the HFD + RM mice than in the HFD mice ( < 0.05). HFD + RM mice had 40% less hepatic steatosis ( < 0.05) and lower upregulation of PPAR-α (33%), ACOX1 (50%), NRF2 (39%), and HO-1 (68%) protein concentrations than did the HFD mice ( < 0.05). Our findings suggest that RM supplementation prevents the obese phenotype observed in HFD-fed mice by downregulating inflammatory cytokine expression and secretion and stimulating hepatic antioxidant and fatty acid oxidation markers.
[Mh] Termos MeSH primário: Inflamação/tratamento farmacológico
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
PPAR alfa/metabolismo
Óleos Vegetais/farmacologia
Rosa/química
[Mh] Termos MeSH secundário: Animais
Glicemia
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/efeitos adversos
Heme Oxigenase-1/genética
Heme Oxigenase-1/metabolismo
Insulina/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/genética
PPAR alfa/genética
Óleos Vegetais/química
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fats); 0 (Insulin); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (PPAR alpha); 0 (Plant Oils); EC 1.14.14.18 (Heme Oxygenase-1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.3945/jn.116.243261



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