Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.779 [Categoria DeCS]
Referências encontradas : 46 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 5 ir para página              

  1 / 46 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28718964
[Au] Autor:Nam SH; Lkhagvasuren K; Seo HW; Kim JK
[Ad] Endereço:Department of Biomedical Science, Catholic University of Daegu, Gyeongsan-si, 38430, Korea.
[Ti] Título:Antiangiogenic Effects of Ziyuglycoside II, a Major Active Compound of Sanguisorba officinalis L.
[So] Source:Phytother Res;31(9):1449-1456, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ziyuglycoside II, a major bioactive compound of Sanguisorba officinalis L., displays anticancer potential against several human cancer cells. However, little information concerning its antiangiogenic properties and possible mechanisms is available. The aim of this study was to investigate the inhibitory effects of ziyuglycoside II on angiogenesis. Ziyuglycoside II inhibited the proliferation, migration, and tubule formation of human umbilical vein endothelial cells, as well as the number of microvessels growing from the aortic rings. The underlying antiangiogenic mechanism of ziyuglycoside II correlated with blocking vascular endothelial growth factor receptor-2 and the fibroblast growth factor receptor-1 mediated signaling pathway. Moreover, an in vivo Matrigel plug assay in mice showed a significant decrease in vascularization and hemoglobin content in the plugs from ziyuglycoside II-treated mice compared with control mice. Overall, these results suggest that ziyuglycoside II inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Neovascularização Patológica/tratamento farmacológico
Sanguisorba/química
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Seres Humanos
Técnicas In Vitro
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Ratos Sprague-Dawley
Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo
Transdução de Sinais/efeitos dos fármacos
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Saponins); 0 (ziyuglycoside II); EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5874


  2 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28323877
[Au] Autor:Ma J; Meng X; Guo X; Lan Y; Zhang S
[Ad] Endereço:Department of Herbology, College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea.
[Ti] Título:Thermal analysis during partial carbonizing process of rhubarb, moutan and burnet.
[So] Source:PLoS One;12(3):e0173946, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Control of temperature and duration of partial carbonization for Chinese medicines have been mainly based on experience of the processors. No quantitative methods and parameters are available that can be used to precisely control the temperature and determine the energy changes during the process. In our research, with a simulated atmosphere air condition, the partial carbonization processes of three Chinese herb medicines rhubarb, moutan and burnet were simulated at different heating rates (5, 10 and 20°C • min-1) and analyzed by thermal gravimetric analysis (TGA) to quantify the upper limits of the temperature. The activation energy was calculated with Friedman, Kissinger-Akahira-Sunose (KAS) method and Ozawa-Flynn-Wall (OFW) methods in iso-conversional models and independent parallel reaction model (IPR). The upper temperatures were calculated to be 280, 184 and 246°C for rhubarb, moutan and burnet, respectively, at corresponding conversion rates of 0.4, 0.2 and 0.1. Calculation of the activation energy has been found impossible with the IPR model. Results obtained from the three iso-conversional methods were different. For rhubarb and burnet, the conversion rates at the upper temperature limits were at the highest or second highest activation energy, while for moutan, it was at the lowest value of activation energy. These results confirmed scientific rationales of traditional Chinese medicine theory that rhubarb and burnet be prepared at high temperature and moutan be prepared at medium temperature. Application of thermal analysis techniques would broaden and deepen traditional Chinese medicine research, and are applicable to the processing of medicinal materials including traditional Chinese medicines. Results obtained from the study could provide new ideas and methods for research to modernize the preparation of traditional Chinese medicines.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Paeonia/química
Rheum/química
Sanguisorba/química
[Mh] Termos MeSH secundário: Carbono/química
Análise Diferencial Térmica
Temperatura Alta
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 7440-44-0 (Carbon)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173946


  3 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28249548
[Au] Autor:Zhao Z; He X; Zhang Q; Wei X; Huang L; Fang JC; Wang X; Zhao M; Bai Y; Zheng X
[Ad] Endereço:* Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University Xi'an 710069, P. R. China.
[Ti] Título:Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Sanguisorba L.
[So] Source:Am J Chin Med;45(2):199-224, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Plants from the genus Sanguisorba have been treated as medicinal ingredients for over 2000 years. This paper reviews advances in the botanical, phytochemical and pharmacological studies of the genus. To date, more than 120 chemical constituents have been isolated and identified from these plants, especially from S. officinalis and S. minor. Among these compounds, triterpenoids, phenols and flavonoids are the primary biologically active constituents. Triterpenoids can be used as quality control markers to determine the quality of medicinal materials and their preparations. In vivo and in vitro studies have shown that plants from the genus Sanguisorba exhibit a wide range of pharmacological properties, including hemostatic, antibacterial, antitumor, neuroprotective and hypoglycemic activities. In Chinese medical practice, many drugs (e.g., tablets and powders) that contain S. officinalis roots have been used to treat leukopenia, hemorrhaging and burns. However, there is still a multitude of Sanguisorba species that have garnered little or no attention. Indeed, there are few reports concerning the clinical use and toxic effects of these plants. Further attention should be focused on the study of these species in order to gather information on their respective toxicology data, any relevant quality-control measures, and the clinical value of the crude extracts, active compounds, and bioactive metabolites from Genus Sanguisorba.
[Mh] Termos MeSH primário: Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Sanguisorba/química
[Mh] Termos MeSH secundário: Animais
Antialérgicos
Antibacterianos
Anti-Inflamatórios
Antineoplásicos Fitogênicos
Antioxidantes
Células Cultivadas
Coagulantes
Flavonoides/isolamento & purificação
Seres Humanos
Hipoglicemiantes
Técnicas In Vitro
Fármacos Neuroprotetores
Fenóis/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Coagulants); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Neuroprotective Agents); 0 (Phenols); 0 (Plant Extracts); 0 (Triterpenes)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500136


  4 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27664921
[Au] Autor:Pawlaczyk-Graja I; Balicki S; Ziewiecki R; Matulová M; Capek P; Gancarz R
[Ad] Endereço:Departament of Organic and Pharmaceutical Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 29, 50-370, Wroclaw, Poland. Electronic address: izabela.pawlaczyk@pwr.wroc.pl.
[Ti] Título:Polyphenolic-polysaccharide conjugates of Sanguisorba officinalis L. with anticoagulant activity mediated mainly by heparin cofactor II.
[So] Source:Int J Biol Macromol;93(Pt A):1019-1029, 2016 Dec.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A macromolecular complex has been isolated from the dried flowering parts of medicinal plant Sanguisorba officinalis L. (So) by multi-step extraction procedure, including that with extraction by organic solvents to degrease the plant material, then with hot alkali, followed by neutralization, partitioning with organic solvents and dialysis. The complex was purified by size-exclusion chromatography into five fractions labeled as So1-So5. Individual fractions differed in the chemical composition and molecular weight distribution patterns. In vitro anticoagulant activity tests showed in all fractions more or less important inhibition of plasma clots, however, So3 and So4 were the most active. The anticoagulant activity of So3 was even more significant than that of the unfractionated complex So. These S. officinalis conjugates were able to inhibit mainly the activity of thrombin when they were mediated by heparin cofactor II, but what was unexpected they were the non-direct inhibitors of factor Xa, mediated by antitrombin, where such mechanism of action is typical for a highly sulphated glycosaminoglycans.
[Mh] Termos MeSH primário: Anticoagulantes/farmacologia
Cofator II da Heparina/fisiologia
Extratos Vegetais/farmacologia
Polifenóis/farmacologia
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Anticoagulantes/isolamento & purificação
Avaliação Pré-Clínica de Medicamentos
Flores/química
Seres Humanos
Tempo de Tromboplastina Parcial
Extratos Vegetais/isolamento & purificação
Polifenóis/isolamento & purificação
Polissacarídeos/isolamento & purificação
Tempo de Protrombina
Sanguisorba/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Plant Extracts); 0 (Polyphenols); 0 (Polysaccharides); 81604-65-1 (Heparin Cofactor II)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  5 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27599590
[Au] Autor:Yang JH; Yoo JM; Cho WK; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
[Ti] Título:Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.
[So] Source:BMC Complement Altern Med;16:347, 2016 Sep 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-contact dermatitis bioactivities. METHODS: In this study, we investigated the mechanism underlying the anti-inflammatory effects of SR water extract (WSR) using human keratinocyte (HaCaT) cells and BALB/c mouse bone marrow-derived mast cells (BMMCs). Viability assays were used to evaluate non-cytotoxic concentrations of WSR in both BMMCs and HaCaT cells. To investigate the effect of WSR treatment on the degranulation of IgE/Ag-activated BMMCs, we measured the release of ß-hexosaminidase (ß-HEX). We determined the production of pro-inflammatory chemokines including thymus and activation regulated chemokine (TARC; CCL17), regulated on activation, normal T-cell expressed and secreted (RANTES; CCL5), macrophage-derived chemokine (MDC; CCL22), and interleukin 8 (IL-8; CXCL8) in stimulated human keratinocytes. The ability of WSR to reduce the expression of pro-inflammatory marker proteins was evaluated by Western blotting in HaCaT cells stimulated with tumor necrosis factor (TNF)-α/interferon (IFN)-γ. RESULT: WSR inhibited IgE/Ag-activated mast cell degranulation in BMMCs. Treatment with various concentrations of WSR decreased ß-HEX release in a dose-dependent manner with an IC50 of 27.5 µg/mL. In keratinocytes, WSR suppressed TNF-α/IFN-γ-induced chemokine production and pro-inflammatory molecules via a blockade STAT-1, Jak-2, p38, and JNK activation. CONCLUSIONS: This results demonstrate that WSR inhibits degranulation of IgE/Ag-activated mast cells and inhibits the production of pro-inflammatory chemokines by suppressing the phosphorylation of p38 and JNK in HaCaT cells.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Degranulação Celular/efeitos dos fármacos
Janus Quinase 2/metabolismo
Mastócitos/efeitos dos fármacos
Extratos Vegetais/química
Fator de Transcrição STAT1/metabolismo
Sanguisorba/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Linhagem Celular Tumoral
Células Cultivadas
Quimiocinas/metabolismo
Seres Humanos
Queratinócitos/citologia
Masculino
Mastócitos/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Chemokines); 0 (Plant Extracts); 0 (STAT1 Transcription Factor); EC 2.7.10.2 (Janus Kinase 2)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1317-4


  6 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27309406
[Au] Autor:Jung DW; Lee OH; Kang IJ
[Ad] Endereço:1 Department of Food Science and Nutrition, Hallym University , Gangwon, Korea.
[Ti] Título:Sanguisorba officinalis L. Extracts Exert Antiobesity Effects in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets.
[So] Source:J Med Food;19(8):768-79, 2016 Aug.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the antiobesity effect of Sanguisorba officinalis L. (SOL) in 3T3-L1 adipocytes and obese C57BL/6J mice. SOL was extracted with water and 30%, 50%, 70%, and 100% ethanol (EtOH). 3T3-L1 adipocytes were treated with SOL extracts (100 µg/mL) during the differentiation period. Triglyceride (TG) accumulation was determined by Oil Red O staining, and the expression of adipocyte-specific proteins was measured by Western blot analysis. C57BL/6J mice were fed a high-fat diet to induce obesity and were orally administered SOL 50% ethanol extract (50, 100, and 200 mg/kg) for 8 weeks. Among the SOL extracts, the 50% EtOH extract considerably inhibited TG accumulation through the downregulation of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. In addition, the 50% ethanol extract reduced body weight and adipose tissue weight and improved serum lipid profiles through downregulation of PPARγ, C/EBPα, FABP4, and ACC and upregulation of adiponectin and CPT-1 in obese C57BL/6J mice fed a high-fat diet. These results suggested that the SOL 50% EtOH extract may have an antiobesity effect through the regulation of transcription factors related to adipogenesis, lipogenesis, and lipolysis.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Fármacos Antiobesidade/farmacologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Obesidade/sangue
Extratos Vegetais/farmacologia
Sanguisorba
Fatores de Transcrição/sangue
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/metabolismo
Adipogenia
Adiponectina/sangue
Animais
Fármacos Antiobesidade/uso terapêutico
Proteína alfa Estimuladora de Ligação a CCAAT/sangue
Dieta Hiperlipídica
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Obesidade/etiologia
PPAR gama/sangue
Fitoterapia
Extratos Vegetais/uso terapêutico
Proteína de Ligação a Elemento Regulador de Esterol 1/sangue
Triglicerídeos/sangue
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Anti-Obesity Agents); 0 (CCAAT-Enhancer-Binding Protein-alpha); 0 (PPAR gamma); 0 (Plant Extracts); 0 (Sterol Regulatory Element Binding Protein 1); 0 (Transcription Factors); 0 (Triglycerides)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.3704


  7 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27065570
[Au] Autor:Yang JH; Yoo JM; Cho WK; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea.
[Ti] Título:Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions.
[So] Source:Mediators Inflamm;2016:2947390, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sanguisorbae Radix (SR) is well known as herbal medicine named "Zi-Yu" in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice model. Oral administration of ESR significantly suppressed DNCB-induced AD-like symptoms such as scratching behavior, ear thickness, epidermal thickness, and IgE levels. To investigate the effects of ESR treatment on degranulation of IgE/Ag-activated mouse bone marrow-derived mast cells (BMMCs), we measured the release of ß-hexosaminidase (ß-HEX, degranulation marker). ESR decreased the infiltration of eosinophils and mast cells into the AD skin lesions. Furthermore, ESR significantly inhibited degranulation of IgE/Ag-activated BMMCs. We have demonstrated that ESR decreased AD symptoms in mice and inhibits degranulation of IgE/Ag-activated mast cells. Our study suggests that ESR may serve as a potential therapeutic candidate for the treatment of AD symptoms.
[Mh] Termos MeSH primário: Dermatite Atópica/patologia
Dinitroclorobenzeno/toxicidade
Etanol/química
Mastócitos/citologia
Mastócitos/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Sanguisorba/química
Dermatopatias/induzido quimicamente
Dermatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Masculino
Mastócitos/patologia
Camundongos
Camundongos Endogâmicos C3H
Dermatopatias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 3K9958V90M (Ethanol); GE3IBT7BMN (Dinitrochlorobenzene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE
[do] DOI:10.1155/2016/2947390


  8 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26655409
[Au] Autor:Yang JH; Hwang YH; Gu MJ; Cho WK; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu, 701-300, Republic of Korea.
[Ti] Título:Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells.
[So] Source:Phytomedicine;22(14):1262-8, 2015 Dec 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sanguisorba officinalis L. (SOL) is a perennial plant widely distributed in Asia, its roots are well-known as a traditional herbal medicine to treat burns, chronic intestinal infections, scalds, and inflammation in Korea. Also, the roots of SOL are used for treatment of many types of allergic skin diseases, including urticarial, eczema, and allergic dermatitis. PURPOSE: In this study we investigated the underlying mechanism of anti-inflammatory effect of an ethanol extract of SOL roots (ESOL). STUDY DESIGN: The ability of ESOL to inhibit inflammatory skin disorder was tested in human keratinocyte HaCaT cells. METHODS: Viability test using MTT assay were used to determine non-cytotoxic concentrations of ESOL on HaCaT cells. ESOL-mediated inhibition of the tumor necrosis factor (TNF)-α/interferon (IFN)-γ-induced production of pro-inflammatory chemokines-such as macrophage-derived chemokine (MDC), regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin (IL)-8, and thymus and activation regulated chemokine (TARC)-at the mRNA level was determined by real-time reverse transcription-polymerase chain reaction (RT-PCR). The ability of ESOL to reduce the expression of pro-inflammatory marker proteins was evaluated by Western blot analysis and immunocytochemistry. RESULTS: ESOL reduced the production of MDC, RANTES, IL-8, and TARC in HaCaT cells stimulated with TNF-α/IFN-γ at both protein and mRNA levels. ESOL also suppressed the phosphorylation of signal transducer and activator of transcription (STAT)-1, extracellular signal-regulated kinase (ERK), and inhibited both nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha (IκB-α) degradation and the nuclear translocation of NF-κB/p65. ESOL exerts anti-inflammatory effects by suppressing the expression of TNF-α/IFN-γ-stimulated chemokines and pro-inflammatory molecules via a blockade NF-κB, STAT-1, and ERK activation. CONCLUSION: Our results suggest the preventive potential of ESOL as a herbal medicine for the treatment of inflammatory skin diseases.
[Mh] Termos MeSH primário: Quimiocinas/metabolismo
Queratinócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Sanguisorba/química
[Mh] Termos MeSH secundário: Linhagem Celular
Quimiocina CCL17/metabolismo
Quimiocina CCL22/metabolismo
Quimiocina CCL5/metabolismo
Dermatite Atópica/tratamento farmacológico
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Proteínas I-kappa B/metabolismo
Inflamação/tratamento farmacológico
Interferon gama/farmacologia
Interleucina-8/metabolismo
Inibidor de NF-kappaB alfa
NF-kappa B/metabolismo
Fosforilação
Fitoterapia
Fator de Transcrição STAT1/metabolismo
Pele/efeitos dos fármacos
Fator de Transcrição RelA/metabolismo
Fator de Necrose Tumoral alfa/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CCL17 protein, human); 0 (CCL5 protein, human); 0 (Chemokine CCL17); 0 (Chemokine CCL22); 0 (Chemokine CCL5); 0 (Chemokines); 0 (I-kappa B Proteins); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (NF-kappa B); 0 (NFKBIA protein, human); 0 (Plant Extracts); 0 (RELA protein, human); 0 (STAT1 Transcription Factor); 0 (STAT1 protein, human); 0 (Transcription Factor RelA); 0 (Tumor Necrosis Factor-alpha); 139874-52-5 (NF-KappaB Inhibitor alpha); 82115-62-6 (Interferon-gamma); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE


  9 / 46 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26454299
[Au] Autor:Chen X; Shang F; Meng Y; Li L; Cui Y; Zhang M; Qi K; Xue T
[Ad] Endereço:School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China.
[Ti] Título:Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formation of methicillin-resistant Staphylococcus aureus in an ica-dependent manner.
[So] Source:J Dairy Sci;98(12):8486-91, 2015 Dec.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen that shows resistance to many antibiotics and is usually associated with serious infections. Having the ability for biofilm formation increases resistance to antibiotics. Sanguisorba officinalis L. is a perennial plant that is distributed in the northern districts of China and has been used as a traditional Chinese medicine. In this study, the effect of S. officinalis on MRSA strain SA3 isolated from a dairy cow with mastitis was evaluated by testing the growth and biofilm formation ability of MRSA cultured with or without ethanol extracts of S. officinalis. The results showed that the ethanol extract of S. officinalis strongly inhibited the biofilm formation of MRSA. With a confocal laser scanning microscope system, we observed that the biofilm structure of the test group with the addition of S. officinalis appeared looser and had less biomass compared with the control group without S. officinalis. Furthermore, we found that the transcript levels of the icaADBC operon remarkably decreased upon addition of the ethanol extract of S. officinalis, indicating that S. officinalis inhibits biofilm formation of MRSA in an ica-dependent manner.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Biofilmes/crescimento & desenvolvimento
Staphylococcus aureus Resistente à Meticilina/fisiologia
Extratos Vegetais/farmacologia
Sanguisorba/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Bovinos
China
Infecção Hospitalar
Etanol
Feminino
Mastite Bovina/microbiologia
Meticilina
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Microscopia Confocal
Fitoterapia
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 3K9958V90M (Ethanol); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151123
[Lr] Data última revisão:
151123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151012
[St] Status:MEDLINE


  10 / 46 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26397864
[Au] Autor:Park S; Kim DS; Kang S; Shin BK
[Ad] Endereço:Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, Chungnam 336­795, Republic of Korea.
[Ti] Título:Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.
[So] Source:Mol Med Rep;12(5):7657-64, 2015 11.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. Therefore, the present study investigated the efficacy of CPE, SOE, and CPE+SOE in the treatment of atopic dermatitis-like symptoms in mice. Following topical application of 1,3­butylen glycol (control), 30% CPE, 30% SOE, 15% CPE+15% SOE or 0.1% hydrocortisone (HC) on the atopic dermatitis­like skin lesions of 2,4-dinitrochlorobenzene­treated NC/Nga mice for 5 weeks, the severity of clinical atopic dermatitis, mast cell infiltration, serum expression levels of immunoglobulin (Ig)E, IgG1, interleukin (IL)-4 and interferon (IFN)-γ, and cytokine expression in the dorsal skin were measured. Compared with the control group, treatment with CPE alleviated the clinical severity of the AD symptoms, with decreased numbers of mast cells, decreased expression levels of serum tumor necrosis factor (TNF)­α, IL­4 and IFN­Î³, and decreased expression levels of inflammatory cytokines in the dorsal lesions. Treatment with SOE did not reduce these expression levels, however, the serum expression levels of IgE and IgG1 were suppressed to similar levels as those in the CPE group. Furthermore, synergistic treatment with CPE and SOE relieved the clinical severity of atopic dermatitis, reduced the serum expression levels of IgE, IgG1, TNF­α, IL­4 and IFN­Î³, and suppressed the mRNA expression levels of TNF­α, IL­4, IL­13, and IFN­Î³ in the dorsal skin lesions. Treatment with CPE+SOE was superior to treatment with HC alone for reducing dermal thickness and suppressing the production of several cytokines. Therefore, combined treatment with CPE and SOE may be an effective alternative intervention for the management of atopic dermatitis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Dermatite Atópica/tratamento farmacológico
Phellodendron/química
Extratos Vegetais/uso terapêutico
Sanguisorba/química
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Anti-Inflamatórios/química
Citocinas/sangue
Dermatite Atópica/sangue
Dermatite Atópica/patologia
Flavonoides/química
Flavonoides/uso terapêutico
Imunoglobulina E/sangue
Masculino
Camundongos
Fenóis/química
Fenóis/uso terapêutico
Extratos Vegetais/química
Sais/química
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Salts); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150924
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2015.4348



página 1 de 5 ir para página              
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde