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Pesquisa : B01.650.940.800.575.912.250.859.937.500.793 [Categoria DeCS]
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  1 / 130 MEDLINE  
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[PMID]:28614366
[Au] Autor:Liu C; Dou Y; Guan X; Fu Q; Zhang Z; Hu Z; Zheng J; Lu Y; Li W
[Ad] Endereço:College of Landscape Architecture, Beijing University of Agriculture, Beijing, China.
[Ti] Título:De novo transcriptomic analysis and development of EST-SSRs for Sorbus pohuashanensis (Hance) Hedl.
[So] Source:PLoS One;12(6):e0179219, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sorbus pohuashanensis is a native tree species of northern China that is used for a variety of ecological purposes. The species is often grown as an ornamental landscape tree because of its beautiful form, silver flowers in early summer, attractive pinnate leaves in summer, and red leaves and fruits in autumn. However, development and further utilization of the species are hindered by the lack of comprehensive genetic information, which impedes research into its genetics and molecular biology. Recent advances in de novo transcriptome sequencing (RNA-seq) technology have provided an effective means to obtain genomic information from non-model species. Here, we applied RNA-seq for sequencing S. pohuashanensis leaves and obtained a total of 137,506 clean reads. After assembly, 96,213 unigenes with an average length of 770 bp were obtained. We found that 64.5% of the unigenes could be annotated using bioinformatics tools to analyze gene function and alignment with the NCBI database. Overall, 59,089 unigenes were annotated using the Nr database(non-redundant protein database), 35,225 unigenes were annotated using the GO (Gene Ontology categories) database, and 33,168 unigenes were annotated using COG (Cluster of Orthologous Groups). Analysis of the unigenes using the KEGG (Kyoto Encyclopedia of Genes and Genomes) database indicated that 13,953 unigenes were involved in 322 metabolic pathways. Finally, simple sequence repeat (SSR) site detection identified 6,604 unigenes that included EST-SSRs and a total of 7,473 EST-SSRs in the unigene sequences. Fifteen polymorphic SSRs were screened and found to be of use for future genetic research. These unigene sequences will provide important genetic resources for genetic improvement and investigation of biochemical processes in S. pohuashanensis.
[Mh] Termos MeSH primário: Etiquetas de Sequências Expressas
Perfilação da Expressão Gênica/métodos
Repetições de Microssatélites
Sorbus/genética
[Mh] Termos MeSH secundário: DNA de Plantas/genética
Regulação da Expressão Gênica de Plantas
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Anotação de Sequência Molecular
Folhas de Planta/genética
Análise de Sequência de RNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179219


  2 / 130 MEDLINE  
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[PMID]:28344107
[Au] Autor:Li M; Ohi-Toma T; Gao YD; Xu B; Zhu ZM; Ju WB; Gao XF
[Ad] Endereço:CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China; University of Chinese Academy of
[Ti] Título:Molecular phylogenetics and historical biogeography of Sorbus sensu stricto (Rosaceae).
[So] Source:Mol Phylogenet Evol;111:76-86, 2017 Jun.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Explaining how plants from eastern Asia migrated to other Northern Hemisphere regions is still challenging. The genus Sorbus sensu stricto (including c. 88 species) is considered as a good example to illuminate this scenario, due to the wide distribution in the temperate zone and high diversity in the Himalayas and Hengduan Mountains. Based on four nuclear markers (LEAFY-2, GBSSI-1, SBEI and WD) and one chloroplast marker (rps16-trnK), we reconstructed the phylogenetic relationship of Sorbus using 54 taxa (60% of the genus representing all subgenera, sections, or series and geographical areas in the previous classifications), and estimated divergence time and historical biogeography of the genus. Phylogenetic analyses supported that the subgenera Sorbus and Albo-carmesinae, as defined by traditional morphological characters (such as fruit color), are suitable. However, five clades defined by phylogenetic analysis of the genus are not consistent with traditionally defined sections or series. Molecular dating and biogeographic reconstruction showed that the age of the most recent common ancestor was estimated at 41mya (95% HPD: 49-35mya) in eastern Asia. Four dispersal events are assumed to explain the wide distribution of Sorbus in the temperate zone and diversification in the edges of Qinghai-Tibet Plateau (QTP). Species dispersed from eastern Asia to the Tianshan Mountains, North America and Europe during the Oligocene and Miocene period. We found that polyploidization occurred multiple times in the subgenus Albo-carmesinae, in the Tianshan Mountains, Himalayas, and H-D Mountains. Finally, we suggest that apomixis, polyploidization, and hybridization may have combined with the multistage uplifting of Himalayas and H-D Mountains (and the subsequent increases in geologic, ecological and climatic heterogeneity) to drive the striking species diversity of Sorbus in this region.
[Mh] Termos MeSH primário: Filogenia
Filogeografia
Sorbus/classificação
[Mh] Termos MeSH secundário: Teorema de Bayes
Núcleo Celular/genética
DNA de Cloroplastos/genética
Fósseis
Funções Verossimilhança
Análise de Sequência de DNA
Sorbus/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


  3 / 130 MEDLINE  
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[PMID]:28338629
[Au] Autor:Zeiner M; Juranovic Cindric I; Majic B; Stingeder G
[Ad] Endereço:Division of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, BOKU, Muthgasse 18, 1190 Vienna, Austria. michaela.zeiner@boku.ac.at.
[Ti] Título:Study of the Accumulation of Toxic and Essential Ultra-Trace Elements in Fruits of Sorbus domestica L.
[So] Source:Int J Environ Res Public Health;14(4), 2017 Mar 24.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present work, the accumulation of selected toxic and essential ultra-trace elements in fruits of service tree ( L.) were determined depending on harvest time. Samples were collected from the same sampling area in two different years and within one year in September and October (maturity state). Harvesting the fruits in the same area excludes the influence of metals taken up via roots, thus the impact of airborne contamination by heavy metal translocation can be studied. All samples were dried and digested using an acidic microwave assisted digestion system prior to quantification by inductively coupled plasma-sector field mass spectrometry (ICP-SFMS). The elements chosen were Arsenic and Cadmium as well as Lithium, Molybdenum, and Selenium. The Arsenic content rose with maturity in mesocarp. Cadmium found in the mesocarp was unaffected by ripeness. For Selenium and Molybdenum, no statistically significant effect of ripeness could be found on their content in mesocarp. Lithium could not be detected in the majority of fruit samples. Differences between the metal concentrations based on the year of harvest were found for Arsenic, Molybdenum, and Selenium, depending on precipitation. The drier the season, the more Arsenic was accumulated. For Molybdenum and Selenium, the opposite effect was observed.
[Mh] Termos MeSH primário: Poluentes Ambientais/metabolismo
Frutas/metabolismo
Metais Pesados/metabolismo
Sorbus/metabolismo
Oligoelementos/metabolismo
[Mh] Termos MeSH secundário: Poluentes Ambientais/química
Metais Pesados/química
Chuvas
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy); 0 (Trace Elements)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  4 / 130 MEDLINE  
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[PMID]:28182841
[Au] Autor:Mikulic-Petkovsek M; Krska B; Kiprovski B; Veberic R
[Ad] Endereço:Univ. of Ljubljana, Biotechnical Faculty, Dept. of Agronomy, Chair for Fruit, Viticulture and Vegetable Growing, Ljubljana, Slovenia.
[Ti] Título:Bioactive Components and Antioxidant Capacity of Fruits from Nine Sorbus Genotypes.
[So] Source:J Food Sci;82(3):647-658, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, biochemical profile of fruits of 9 Sorbus genotypes was analyzed. The content of total sugars ranged from 69.7 g/kg ('Titan') to 217.5 g/kg (Sorbus torminalis) and total organic acids from 17.7 g/kg ('Businka') to 40.2 g/kg (S. torminalis). The highest content of total anthocyanins had 'Burka' (871 mg/kg FW) and 'Businka' (856 mg/kg FW). Quercetin derivatives represented more than 95% of total flavonols. 'Alaja krupnaja' had 3.5- to 29-fold higher rutin content than other analyzed genotypes. S. torminalis fruits had the greatest diversity of isorhamnetin and kaempferol derivatives. Chlorogenic acid was the major hydroxycinnamic acid and its share was 33% to 73% of total analyzed hydoxycinnamic acid derivatives. The richest in chlorogenic acid were 'Krasavica' and 'Alaja krupnaja' fruits. Cultivar 'Businka' had the highest content of epicatechin (40.7 mg/kg) and neochlorogenic acid (1061 mg/kg). Different procyanidin oligomers were detected among flavanols in Sorbus fruits. The highest content of total flavanols was measured in 'Alaja Krupnaja' fruits. Cultivars 'Krasavica' (84.5 mg/kg) and 'Burka' (85.1 mg/kg) had 1.2- to 6.9-fold higher amount of total carotenoids. 'Businka' was highlighted as the richest in total tannin and phenolic contents (3768 mg GAE/kg) and consequently, it had the highest antioxidant activity (57.6 mM TE/kg FW). Being abundant in polyphenolics, some extracts of Sorbus genotypes, for example, 'Businka,' 'Burka,' and 'Alaja krupnaja' could serve as valuable resource of bioactive compounds to food and pharmaceutical industries.
[Mh] Termos MeSH primário: Antioxidantes/análise
Carotenoides/análise
Frutas/química
Genótipo
Extratos Vegetais/química
Polifenóis/análise
Sorbus/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Biflavonoides/análise
Catequina/análise
Ácido Clorogênico/análogos & derivados
Ácido Clorogênico/análise
Flavonóis/análise
Quempferóis/análise
Fenóis/análise
Proantocianidinas/análise
Quercetina/análogos & derivados
Quercetina/análise
Ácido Quínico/análogos & derivados
Ácido Quínico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Biflavonoids); 0 (Flavonols); 0 (Kaempferols); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols); 0 (Proanthocyanidins); 058C04BGYI (Quinic Acid); 07X3IB4R4Z (3-methylquercetin); 318ADP12RI (Chlorogenic Acid); 36-88-4 (Carotenoids); 4852-22-6 (procyanidin); 731P2LE49E (kaempferol); 8R1V1STN48 (Catechin); 9IKM0I5T1E (Quercetin); O4601UER1Z (5'-O-caffeoylquinic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13643


  5 / 130 MEDLINE  
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[PMID]:28092839
[Au] Autor:Yu X; Wang Z; Shu Z; Li Z; Ning Y; Yun K; Bai H; Liu R; Liu W
[Ad] Endereço:School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China; College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
[Ti] Título:Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity.
[So] Source:Biomed Pharmacother;88:1-10, 2017 Apr.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The cardiotoxicity of arsenic trioxide (ATO) limits its clinical application in cancer treatment. Evidences suggest that sorbus has antioxidant activity and its consumption has been linked with improved cardioprotection. In this study, we investigated the cardio-protective effect and mechanisms of Sorbus pohuashanensis (Hante) Hedl. flavonoids (SPF) against ATO in BALB/c mice and H9c2 cells. Eleven major flavonoids were confirmed by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-Q-TOF-MS). SPF recovered the ATO-induced disordered electrocardiogram (ECG) and abnormal cardiac structure in the heart of mice. At the same time, SPF significantly reduced levels of creatine kinase (CK), creatine kinase-MB (CK-MB) lactate dehydrogenase (LDH), and glutamic oxaloacetic transaminase (GOT) against ATO-induced injury and inhibited ATO-induced apoptosis both in vivo and in vitro. In addition, SPF regulated ATO-induced oxidative stress damage by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in vivo and in vitro, and reducing reactive oxygen species (ROS). Analysis of the oxidative stress pathways showed that SPF prevented the ATO-induced downregulation of phosphorylated protein kinase B (p-Akt) in vivo and in vitro. Pre-treatment of H9c2 cells with SPF inhibited attenuation of nuclear factor (Nrf2) and heme oxygenase (HO-1). Hence, SPF could be used as a preventive and therapeutic plant ingredient against ATO-induced cardiotoxicity.
[Mh] Termos MeSH primário: Cardiotônicos/uso terapêutico
Cardiotoxicidade/tratamento farmacológico
Flavonoides/uso terapêutico
Óxidos/toxicidade
Sorbus/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Arsenicais
Cardiotônicos/farmacologia
Cardiotoxicidade/patologia
Caspases/metabolismo
Morte Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Flavonoides/farmacologia
L-Lactato Desidrogenase/metabolismo
Masculino
Camundongos Endogâmicos BALB C
Miocárdio/patologia
Estresse Oxidativo/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Arsenicals); 0 (Cardiotonic Agents); 0 (Flavonoids); 0 (Oxides); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Reactive Oxygen Species); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.4.22.- (Caspases); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


  6 / 130 MEDLINE  
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[PMID]:27937005
[Au] Autor:Cheon SM; Jang I; Lee MH; Kim DK; Jeon H; Cha DS
[Ad] Endereço:a College of Pharmacy, Woosuk University , Jeonbuk , Republic of Korea.
[Ti] Título:Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans.
[So] Source:Pharm Biol;55(1):481-486, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neurological disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy of S. alnifolia in Parkinson's disease (PD). OBJECTIVE: This study was conducted to identify the protective effects of the methanol extracts of S. alnifolia (MESA) on the dopaminergic (DA) neurodegeneration in Caenorhabditis elegans. MATERIALS AND METHODS: To test the neuroprotective action of MESA, viability assay was performed after 48 h exposure to 1-methyl-4-phenylpyridine (MMP ) in PC12 cells and C. elegans (400 µM and 2 mM of MMP , respectively). Fluorescence intensity was quantified using transgenic mutants such as BZ555 (Pdat-1::GFP) and and UA57 (Pdat-1::GFP and Pdat-1::CAT-2) to determine MESA's effects on DA neurodegeneration in C. elegans. Aggregation of α-synuclein was observed using NL5901 strain (unc-54p::α-synuclein::YFP). MESA's protective effects on the DA neuronal functions were examined by food-sensing assay. Lifespan assay was conducted to test the effects of MESA on the longevity. RESULTS: MESA restored MPP -induced loss of viability in both PC12 cells and C. elegans (85.8% and 54.9%, respectively). In C. elegans, MESA provided protection against chemically and genetically-induced DA neurodegeneration, respectively. Moreover, food-sensing functions were increased 58.4% by MESA in the DA neuron degraded worms. MESA also prolonged the average lifespan by 25.6%. However, MESA failed to alter α-synuclein aggregation. DISCUSSION AND CONCLUSIONS: These results revealed that MESA protects DA neurodegeneration and recovers diminished DA neuronal functions, thereby can be a valuable candidate for the treatment of PD.
[Mh] Termos MeSH primário: 1-Metil-4-fenilpiridínio/toxicidade
Caenorhabditis elegans/efeitos dos fármacos
Neurônios Dopaminérgicos/efeitos dos fármacos
Degeneração Neural
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Sorbus/química
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Comportamento Animal/efeitos dos fármacos
Caenorhabditis elegans/genética
Caenorhabditis elegans/metabolismo
Proteínas de Caenorhabditis elegans/genética
Proteínas de Caenorhabditis elegans/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Citoproteção
Neurônios Dopaminérgicos/metabolismo
Neurônios Dopaminérgicos/patologia
Relação Dose-Resposta a Droga
Comportamento Alimentar/efeitos dos fármacos
Longevidade/efeitos dos fármacos
Metanol/química
Atividade Motora/efeitos dos fármacos
Fármacos Neuroprotetores/isolamento & purificação
Células PC12
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Agregados Proteicos
Ratos
Solventes/química
Fatores de Tempo
alfa-Sinucleína/genética
alfa-Sinucleína/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Protein Aggregates); 0 (Solvents); 0 (alpha-Synuclein); R865A5OY8J (1-Methyl-4-phenylpyridinium); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  7 / 130 MEDLINE  
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[PMID]:27855899
[Au] Autor:Tian Y; Liimatainen J; Alanne AL; Lindstedt A; Liu P; Sinkkonen J; Kallio H; Yang B
[Ad] Endereço:Food Chemistry and Food Development, Department of Biochemistry, University of Turku, FI-20014 Turku, Finland.
[Ti] Título:Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants.
[So] Source:Food Chem;220:266-281, 2017 Apr 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phenolic compounds of berries and leaves of thirteen various plant species were extracted with aqueous ethanol and analyzed with UPLC-DAD-ESI-MS, HPLC-DAD, and NMR. The total content of phenolics was consistently higher in leaves than in berries (25-7856 vs. 28-711mg/100g fresh weight). Sea buckthorn leaves were richest in phenolic compounds (7856mg/100g f.w.) with ellagitannins as the dominant compound class. Sea buckthorn berries contained mostly isorhamnetin glycosides, whereas quercetin glycosides were typically abundant in most samples investigated. Anthocyanins formed the dominating group of phenolics in most dark-colored berries but phenolic acid derivatives were equally abundant in saskatoon and chokeberry berries. Caffeoylquinic acids constituted 80% of the total phenolic content (1664mg/100g f.w.) in bilberry leaves. B-type procyanidins and caffeoylquinic acids were the major phenolic compounds in hawthorn and rowanberry, respectively. Use of leaves of some species with prunasin, tyramine and ß-p-arbutin, may be limited in food applications.
[Mh] Termos MeSH primário: Frutas/química
Fenóis/análise
Extratos Vegetais/análise
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Cromatografia Líquida de Alta Pressão
Crataegus/química
Glicosídeos/análise
Hippophae/química
Hidroxibenzoatos/análise
Espectroscopia de Ressonância Magnética
Prunus/química
Quercetina/análogos & derivados
Quercetina/análise
Ribes/química
Sorbus/química
Vaccinium macrocarpon/química
Vaccinium myrtillus/química
Vaccinium vitis-Idaea/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Glycosides); 0 (Hydroxybenzoates); 0 (Phenols); 0 (Plant Extracts); 07X3IB4R4Z (3-methylquercetin); 29656-58-4 (phenolic acid); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


  8 / 130 MEDLINE  
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[PMID]:27878717
[Au] Autor:Razina TG; Zueva EP; Ulrich AV; Rybalkina OY; Chaikovskii AV; Isaikina NV; Kalinkina GI; Zhdanov VV; Zyuz'kov GN
[Ad] Endereço:E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. razinatg22@gmail.com.
[Ti] Título:Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms.
[So] Source:Bull Exp Biol Med;162(1):93-97, 2016 Nov.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
[Mh] Termos MeSH primário: Antocianinas/farmacologia
Antineoplásicos Alquilantes/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Carcinoma Pulmonar de Lewis/tratamento farmacológico
Ciclofosfamida/farmacologia
Melanoma Experimental/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Carcinoma Pulmonar de Lewis/patologia
Sinergismo Farmacológico
Quimioterapia Combinada
Feminino
Frutas/química
Injeções Intramusculares
Metástase Linfática
Melanoma Experimental/patologia
Camundongos
Camundongos Endogâmicos C57BL
Transplante de Neoplasias
Células-Tronco Neoplásicas/efeitos dos fármacos
Células-Tronco Neoplásicas/patologia
Extratos Vegetais/isolamento & purificação
Sorbus/química
Carga Tumoral/efeitos dos fármacos
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antineoplastic Agents, Alkylating); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 8N3DW7272P (Cyclophosphamide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


  9 / 130 MEDLINE  
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[PMID]:27649118
[Au] Autor:Zhou L; Yang J; Yang G; Kang C; Xiao W; Lv C; Wang S; Tang J; Guo L
[Ad] Endereço:The State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhouliangyun0501@163.com.
[Ti] Título:Biphenyl Phytoalexin in Sorbus pohuashanensis Suspension Cell Induced by Yeast Extract.
[So] Source:Molecules;21(9), 2016 Sep 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Biphenyls are unique phytoalexins de novo synthesized in plants in response to pathogen attack. These compounds are found in Maloideae, a subfamily of the Rosaceae. The anti-microbial activities of biphenyls have been reported in a number of studies and they appear to represent an important defense strategy against pathogens common in the Maloideae, such as species in Malus, Pyrus, Sorbus, and Chaenomeles. Here, cell suspension cultures of Sorbus pohuashanensis were established to study biphenyl phytoalexins formation after yeast extract (YE) treatment. An ultra-performance liquid chromatography (UPLC) method coupled with quadrupole time of flight mass spectrometry (Q-TOF-MS) LC-MS/MS was applied to determine the time course of these biphenyl biomarkers accumulation in YE-treated S. pohuashanensis suspension cells. The results of quantitative analyses show the content of Noraucuparin, 2'-Hydroxyaucuparin, and their glycosides initially increased, then decreased over time. The Noraucuparin content reached its highest (225.76 µg·g(-1)) at 18 h after treatment, 6 hours earlier than that of Noraucuparin 5-O-ß-d-glucopyranoside. The content of 2'-Hydroxyaucuparin reached its highest (422.75 µg·g(-1)) at 30 h after treatment, also earlier than that of its glycoside. The understanding of phytoalexin metabolism in this study may provide a basis for improving Maloideae resistance to pathogens.
[Mh] Termos MeSH primário: Compostos de Bifenilo/metabolismo
Misturas Complexas/farmacologia
Células Vegetais/metabolismo
Sesquiterpenos/metabolismo
Sorbus/metabolismo
Leveduras/química
[Mh] Termos MeSH secundário: Misturas Complexas/química
Sorbus/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Complex Mixtures); 0 (Sesquiterpenes); 37297-20-4 (phytoalexins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


  10 / 130 MEDLINE  
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[PMID]:27386872
[Au] Autor:Kim CS; Suh WS; Subedi L; Kim SY; Choi SU; Lee KR
[Ad] Endereço:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-ku, Suwon, 16419, Republic of Korea.
[Ti] Título:Neuroprotective Fatty Acids from the Stem Bark of Sorbus commixta.
[So] Source:Lipids;51(8):989-95, 2016 Aug.
[Is] ISSN:1558-9307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the bark from the stems of Sorbus commixta led to the isolation and characterization of a new fatty acid, sorcomic acid (1), along with nine known analogues (2-10). The structure of the new compound (1) was determined through NMR ((1)H and (13)C NMR, HSQC, HMBC, and NOESY), MS, and specific optical rotation. The known compounds (2-10) were identified by comparison of their spectroscopic data with those in the literature. The biological activities of all the isolated compounds (1-10) were evaluated: compounds 1, 5, and 7 potently induced NGF secretion from C6 glioma cells (233.40 ± 12.82, 194.40 ± 8.05, and 185.74 ± 10.25 %, respectively) and compound 10 reduced NO levels with an IC50 value of 71.25 µM in murine microglia BV2 cells stimulated by LPS.
[Mh] Termos MeSH primário: Ácidos Graxos/farmacologia
Fator de Crescimento Neural/metabolismo
Fármacos Neuroprotetores/farmacologia
Sorbus/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ácidos Graxos/análise
Ácidos Graxos/química
Estrutura Molecular
Fármacos Neuroprotetores/análise
Fármacos Neuroprotetores/química
Óxido Nítrico/metabolismo
Casca de Planta/química
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Neuroprotective Agents); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); 9061-61-4 (Nerve Growth Factor)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1007/s11745-016-4172-7



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