Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.937.500.808 [Categoria DeCS]
Referências encontradas : 29 [refinar]
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  1 / 29 MEDLINE  
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[PMID]:27336837
[Au] Autor:Elansary HO; Skalicka-Wozniak K; King IW
[Ad] Endereço:Biodiversity Institute of Ontario, University of Guelph, Guelph, ON N1G 2W1, Canada; Department of Floriculture, Ornamental Horticulture and Garden Design, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt. Electronic address: hosammail2003@yahoo.com.
[Ti] Título:Enhancing stress growth traits as well as phytochemical and antioxidant contents of Spiraea and Pittosporum under seaweed extract treatments.
[So] Source:Plant Physiol Biochem;105:310-320, 2016 Aug.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Seaweed extracts (SWE) might play an important role in enhancing growth and phytochemical composition of medicinal shrubs. In this study, we investigate the morphological, physiological and biochemical effects of irrigation levels (100% and 50% of the evapotranspiration rate) coupled with a weekly treatment of SWE of Ascophyllum nodosum at 5 and 7 mL L(-1) as a soil drench or foliar spray on Spiraea nipponica "Snowmound" and Pittosporum eugenioides "Variegatum" grown in containers under controlled greenhouse conditions. In addition, the phenolic and flavonoid content, antioxidant capacity and lipid peroxidation in both plant species was largely enhanced while the proline accumulation was reduced. After 8 weeks of treatments, drought condition reduced plant vegetative growth and gas exchange, as well as leaf water potential, but increased the phenolic and flavonoid contents in leaves, their antioxidant capacities and proline content. The application of SWE enhanced the performance of both species during mild drought conditions by means of increasing leaf number and area, dry weights, plant height, gas exchange and leaf water potential. The maximum vegetative growth, physiological performance and phytochemical composition of both species was achieved using the drench SWE treatments (5 and 7 mL L(-1)) in moderate drought conditions, which improved the plant water status, stomatal conductance, and photosynthetic rate. SWE enhanced plant growth and the phytochemical composition and antioxidant capacity of plant leaves of both species during moderate drought conditions.
[Mh] Termos MeSH primário: Antioxidantes/análise
Compostos Fitoquímicos/análise
Característica Quantitativa Herdável
Rosales/crescimento & desenvolvimento
Alga Marinha/química
Spiraea/crescimento & desenvolvimento
Estresse Fisiológico
[Mh] Termos MeSH secundário: Análise de Variância
Biomassa
Peroxidação de Lipídeos
Folhas de Planta/anatomia & histologia
Prolina/metabolismo
Rosales/anatomia & histologia
Rosales/metabolismo
Spiraea/anatomia & histologia
Spiraea/metabolismo
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phytochemicals); 059QF0KO0R (Water); 9DLQ4CIU6V (Proline)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE


  2 / 29 MEDLINE  
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[PMID]:26837236
[Au] Autor:Tang DH; Ma D; Cheng H; Li YL; Xu L
[Ad] Endereço:Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China. liangxu@scu.edu.cn.
[Ti] Título:A bio-inspired synthetic route to the core ring systems of Spiraea atisine-type diterpenoid alkaloids and related diterpenes.
[So] Source:Org Biomol Chem;14(9):2716-22, 2016 Mar 07.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A bio-inspired synthetic strategy for the efficient construction of the structurally complex azapentacyclic ABEFG ring systems of Spiraea atisine-type diterpenoid alkaloids bearing a characteristic internal carbinolamine ether linkage between C(7) and C(20) has been successfully developed. The highly bridged azapentacyclic core structure was constructed rapidly from a readily prepared trans-6,6-bicyclic AB ring precursor through a 14-step sequence. Highlights of the synthesis include a straightforward formal lactone migration from the tricyclic γ-lactone unit of naturally occurring spiramilactone E, and an efficient biomimetic synthesis of the azapentacyclic ABEFG ring systems of spiramines C and D from the corresponding tetracyclic subunits of spiraminol and spiramilactone B.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Diterpenos/síntese química
Spiraea/química
[Mh] Termos MeSH secundário: Alcaloides/química
Diterpenos/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Diterpenes)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160204
[St] Status:MEDLINE
[do] DOI:10.1039/c6ob00053c


  3 / 29 MEDLINE  
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[PMID]:26625838
[Au] Autor:Ma Y; Mao XY; Huang LJ; Fan YM; Gu W; Yan C; Huang T; Zhang JX; Yuan CM; Hao XJ
[Ad] Endereço:School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, People's Republic of China; The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Guiyang 550002, People's Republic of China.
[Ti] Título:Diterpene alkaloids and diterpenes from Spiraea japonica and their anti-tobacco mosaic virus activity.
[So] Source:Fitoterapia;109:8-13, 2016 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new naturally occurring natural products, including two atisine-type diterpene alkaloids (1 and 2), two atisane-type diterpenes (3 and 4), and a new natural product spiramine C2 (5), along with nine known ones (6-14), were isolated from the ethanolic extracts of the whole plant of Spiraea japonica var. acuminata Franch. Their structures were elucidated by extensive spectroscopic analysis. The anti-tobacco mosaic virus (TMV) activities of all the compounds were evaluated by the conventional half-leaf method. Six compounds (2, 3, 6, 7, 11, and 12) exhibited moderate activities at 100 µg/mL with inhibition rates in the range of 69.4-92.9%, which were higher than that of the positive control, ningnanmycin. Their preliminary structure-activity relationships were also discussed.
[Mh] Termos MeSH primário: Alcaloides/química
Antivirais/química
Diterpenos/química
Spiraea/química
Vírus do Mosaico do Tabaco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Antivirais/isolamento & purificação
Diterpenos/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antiviral Agents); 0 (Diterpenes); 0 (Plant Extracts)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE


  4 / 29 MEDLINE  
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[PMID]:25947443
[Au] Autor:Luo X; Li F; Cai W
[Ad] Endereço:Department of Entomology, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China; Email: unknown.
[Ti] Título:A revision of the Chinese species of Cyamophiliopsis (Hemiptera: Psylloidea: Psyllidae) associated with Spiraea (Rosaceae).
[So] Source:Zootaxa;3936(3):387-407, 2015 Mar 20.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Cyamophiliopsis is a small genus restricted to the Palaearctic Region and associated with Spiraea spp. (Rosaceae). In the present work, following five species are recognized in China: C. pseudofasciata sp. nov., C. sarmatica, C. spinosa sp. nov., C. xinjiangana sp. nov. and C. zaisani. Cyamophiliopsis is diagnosed, redescribed in detail, and its phylogenetic relationships are discussed. All the species are described or redescribed, and the fifth instar immature of C. zaisani is described for the first time. Nomenclatorial problems are discussed concerning the Far East Russian Psylla spiraee which is transferred to Cyamophiliopsis as C. spiraee comb. nov.
[Mh] Termos MeSH primário: Hemípteros/classificação
Spiraea/parasitologia
[Mh] Termos MeSH secundário: Distribuição Animal
Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Tamanho Corporal
China
Ecossistema
Feminino
Hemípteros/anatomia & histologia
Hemípteros/genética
Hemípteros/crescimento & desenvolvimento
Masculino
Tamanho do Órgão
Filogenia
Doenças das Plantas/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150508
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.3936.3.5


  5 / 29 MEDLINE  
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[PMID]:25925344
[Au] Autor:Jang SW; Suh WS; Kim CS; Kim KH; Lee KR
[Ad] Endereço:Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
[Ti] Título:A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs.
[So] Source:Arch Pharm Res;38(11):1943-51, 2015 Nov.
[Is] ISSN:0253-6269
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The phytochemical investigation of the methanol extract from the twigs of Spiraea prunifolia var. simpliciflora (Rosaceae) using column chromatography led to the isolation of a new phenol glycoside, 1-O-(E)-caffeoyl-2-O-p-(E)-coumaroyl-ß-D-glucopyranose (1), together with 16 known phenolic compounds (2-17). The structure of this new compound was elucidated by analysis of spectroscopic data including 1D, 2D nuclear magnetic resonance and HR-FAB-MS data. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Glicosídeos/farmacologia
Fenóis/farmacologia
Spiraea/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Cromatografia em Camada Delgada
Glicosídeos/isolamento & purificação
Seres Humanos
Espectroscopia de Ressonância Magnética
Metanol/química
Neoplasias/tratamento farmacológico
Neoplasias/patologia
Fenóis/isolamento & purificação
Espectrometria de Massas de Bombardeamento Rápido de Átomos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glycosides); 0 (Phenols); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151111
[Lr] Data última revisão:
151111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150501
[St] Status:MEDLINE
[do] DOI:10.1007/s12272-015-0610-y


  6 / 29 MEDLINE  
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[PMID]:25885257
[Au] Autor:Stephan K; Kavanagh KL; Koyama A
[Ad] Endereço:Forest, Rangeland, and Fire Sciences, University of Idaho, Moscow, ID, United States of America; Department of Life and Physical Sciences and Cooperative Research, Lincoln University, Jefferson City, Missouri, United States of America.
[Ti] Título:Comparing the influence of wildfire and prescribed burns on watershed nitrogen biogeochemistry using 15N natural abundance in terrestrial and aquatic ecosystem components.
[So] Source:PLoS One;10(4):e0119560, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated differences in the effects of three low-severity spring prescribed burns and four wildfires on nitrogen (N) biogeochemistry in Rocky Mountain headwater watersheds. We compared paired (burned/unburned) watersheds of four wildfires and three spring prescribed burns for three growing seasons post-fire. To better understand fire effects on the entire watershed ecosystem, we measured N concentrations and δ15N in both the terrestrial and aquatic ecosystems components, i.e., soil, understory plants in upland and riparian areas, streamwater, and in-stream moss. In addition, we measured nitrate reductase activity in foliage of Spiraea betulifolia, a dominant understory species. We found increases of δ15N and N concentrations in both terrestrial and aquatic ecosystem N pools after wildfire, but responses were limited to terrestrial N pools after prescribed burns indicating that N transfer from terrestrial to aquatic ecosystem components did not occur in low-severity prescribed burns. Foliar δ15N differed between wildfire and prescribed burn sites; the δ15N of foliage of upland plants was enriched by 2.9 ‰ (difference between burned and unburned watersheds) in the first two years after wildfire, but only 1.3 ‰ after prescribed burns. In-stream moss δ15N in wildfire-burned watersheds was enriched by 1.3 ‰, but there was no response by moss in prescription-burned watersheds, mirroring patterns of streamwater nitrate concentrations. S. betulifolia showed significantly higher nitrate reductase activity two years after wildfires relative to corresponding unburned watersheds, but no such difference was found after prescribed burns. These responses are consistent with less altered N biogeochemistry after prescribed burns relative to wildfire. We concluded that δ15N values in terrestrial and aquatic plants and streamwater nitrate concentrations after fire can be useful indicators of the magnitude and duration of fire effects and the fate of post-fire available N.
[Mh] Termos MeSH primário: Ecossistema
Nitrogênio/metabolismo
[Mh] Termos MeSH secundário: Fogo
Água Doce/química
Nitrato Redutase/metabolismo
Nitrogênio/química
Isótopos de Nitrogênio/química
Isótopos de Nitrogênio/metabolismo
Solo/química
Spiraea/enzimologia
Spiraea/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nitrogen Isotopes); 0 (Soil); EC 1.7.99.4 (Nitrate Reductase); N762921K75 (Nitrogen)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150418
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0119560


  7 / 29 MEDLINE  
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[PMID]:24684844
[Au] Autor:Yan C; Huang L; Liu HC; Chen DZ; Liu HY; Li XH; Zhang Y; Geng MY; Chen Q; Hao XJ
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China; The Key Laboratory of Chemistry for Natural Product of Guizhou Pr
[Ti] Título:Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.
[So] Source:Bioorg Med Chem Lett;24(8):1884-8, 2014 Apr 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing α,ß-unsaturated ketone induce apoptosis of Bax(-/-)/Bak(-/-) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax(-/-)/Bak(-/-) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with α,ß-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax/Bak-independent manner.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Compostos Heterocíclicos de 4 ou mais Anéis/química
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Proteína Killer-Antagonista Homóloga a bcl-2/efeitos dos fármacos
Proteína X Associada a bcl-2/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antineoplásicos/química
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Deleção de Genes
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Spiraea/química
Proteína Killer-Antagonista Homóloga a bcl-2/genética
Proteína X Associada a bcl-2/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (bcl-2 Homologous Antagonist-Killer Protein); 0 (bcl-2-Associated X Protein); 0 (spiramine C); 0 (spiramine D)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140402
[St] Status:MEDLINE


  8 / 29 MEDLINE  
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[PMID]:24639177
[Au] Autor:Liu HM; Fang L; Che YS; Wu FZ; Yang CP
[Ad] Endereço:College of Forestry, Northeast Forestry University, Harbin, 150040, Heilongjiang, China.
[Ti] Título:Protein expression patterns in two Spiraea species in response to cold treatment.
[So] Source:Mol Biol Rep;41(7):4533-47, 2014 Jul.
[Is] ISSN:1573-4978
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We analyzed the different cold-resistance species Spiraea trichocarpa Nakai and Spiraea bumalda 'Goldmound' for low-temperature protein expression, protein types identification, and investigated the cold resistance mechanisms under different levels of low temperature by two-dimensional gel electrophoresis (2-DE) and mass spectrometry. An average of 668 and 559 protein spots were detected by 2-DE of S. bumalda 'Goldmound' and S. trichocarpa Nakai, respectively, under different low-temperature treatments. Matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy identified 48 proteins, with varying expression, related to metabolism, amino acid synthesis, transportation, stress responses and oxidation-reduction reactions. The results showed that the photosynthesis of S. bumalda 'Goldmound' had been affected, enzymes (RuBisCO large and small subunits) involved in the Calvin cycle were up- and down-regulated, and ATP synthase in photophosphorylation was down-regulated. Cytosolic malate dehydrogenase expression weakened in the TCA cycle, while amino acid synthesis strengthened. The activity of four antioxidant enzymes (superoxide dismutase [Cu-Zn], L-ascorbate peroxidase, glutathione peroxidase and peroxidase) was reduced under varying low temperatures. Enzymes (ribulose-bisphosphate carboxylase and RuBisCO small chain precursor) involved in the photosynthesis of S. trichocarpa Nakai showed obvious up- and down-regulation under low temperatures. Cold treatment influenced the photosynthesis of S. trichocarpa Nakai and S. bumalda 'Goldmound', but the results showed significant differences between the two species, which were supposed to the fact that low temperature modified the metabolic mechanisms and led to the weaker cold resistance in S. bumalda 'Goldmound' than in S. trichocarpa Nakai.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Regulação da Expressão Gênica de Plantas
Folhas de Planta/genética
Spiraea/genética
[Mh] Termos MeSH secundário: Temperatura Baixa
Eletroforese em Gel Bidimensional
Perfilação da Expressão Gênica
Redes e Vias Metabólicas/genética
Anotação de Sequência Molecular
Fotossíntese/genética
Folhas de Planta/metabolismo
Especificidade da Espécie
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Spiraea/metabolismo
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1502
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140319
[St] Status:MEDLINE
[do] DOI:10.1007/s11033-014-3324-1


  9 / 29 MEDLINE  
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[PMID]:24176527
[Au] Autor:Nishikawa K; Fukuda H; Abe M; Nakanishi K; Tazawa Y; Yamaguchi C; Hiradate S; Fujii Y; Okuda K; Shindo M
[Ad] Endereço:Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga-koen, Kasuga 816-8580, Japan.
[Ti] Título:Design and synthesis of conformationally constrained analogues of cis-cinnamic acid and evaluation of their plant growth inhibitory activity.
[So] Source:Phytochemistry;96:223-34, 2013 Dec.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1-O-cis-Cinnamoyl-ß-D-glucopyranose is known to be one of the most potent allelochemical candidates and was isolated from Spiraea thunbergii Sieb by Hiradate et al. (2004), who suggested that it derived its strong inhibitory activity from cis-cinnamic acid, which is crucial for phytotoxicity. In this study, key structural features and substituent effects of cis-cinnamic acid (cis-CA) on lettuce root growth inhibition was investigated. These structure-activity relationship studies indicated the importance of the spatial relationship of the aromatic ring and carboxylic acid moieties. In this context, conformationally constrained cis-CA analogues, in which the aromatic ring and cis-olefin were connected by a carbon bridge, were designed, synthesized, and evaluated as plant growth inhibitors. The results of the present study demonstrated that the inhibitory activities of the five-membered and six-membered bridged compounds were enhanced, up to 0.27 µM, and were ten times higher than cis-CA, while the potency of the other compounds was reduced.
[Mh] Termos MeSH primário: Cinamatos/síntese química
Cinamatos/farmacologia
Desenvolvimento Vegetal/efeitos dos fármacos
Spiraea/química
[Mh] Termos MeSH secundário: Cinamatos/química
Alface/efeitos dos fármacos
Alface/crescimento & desenvolvimento
Conformação Molecular
Estrutura Molecular
Raízes de Plantas/crescimento & desenvolvimento
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cinnamates); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131122
[Lr] Data última revisão:
131122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131102
[St] Status:MEDLINE


  10 / 29 MEDLINE  
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[PMID]:24161492
[Au] Autor:Park SH; Park KH; Oh MH; Kim HH; Choe KI; Kim SR; Park KJ; Lee MW
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
[Ti] Título:Anti-oxidative and anti-inflammatory activities of caffeoyl hemiterpene glycosides from Spiraea prunifolia.
[So] Source:Phytochemistry;96:430-6, 2013 Dec.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Activity guided isolation of a Spiraea prunifolia extract yielded five caffeoyl hemiterpene glycosides: 4'-(6-O-caffeoyl-ß-D-glucopyranosyl)-2'-methyl butyric acid, 1-O-caffeoyl-6-O-(4'-hydroxy-2'-methylene-butyroyl)-ß-D-glucopyranoside, 1,2-O-dicaffeoyl-6-O-(4'-hydroxy-2'-methylene-butyroyl)-ß-D-glucopyranoside, 1-O-caffeoyl-6-O-(4'-caffeoyl-2'-methylene-butyroyl)-ß-D-glucopyranoside, and 1-O-caffeoyl-6-O-(4'-caffeoyl-3'-hydroxy-2'-methylene-butyroyl)-ß-D-glucopyranoside, and nine known compounds. Structures were elucidated by analysis of 1D and 2D NMR spectra and FAB-MS. To evaluate the anti-oxidative and anti-inflammatory properties of all fourteen compounds, DPPH radical scavenging, NBT superoxide scavenging, and inhibition of nitric oxide production in LPS-stimulated RAW264.7 cells were examined. Three of the caffeoyl hemiterpene glycosides exhibited potent anti-oxidative and anti-inflammatory activities compared with Vitamin C and l-NMMA, which were used as positive controls.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Ácidos Cafeicos/isolamento & purificação
Ácidos Cafeicos/farmacologia
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Hemiterpenos/isolamento & purificação
Hemiterpenos/farmacologia
Spiraea/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Antioxidantes/química
Compostos de Bifenilo/farmacologia
Ácidos Cafeicos/química
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Glicosídeos/química
Hemiterpenos/química
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Óxido Nítrico/biossíntese
Ressonância Magnética Nuclear Biomolecular
Picratos/farmacologia
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Caffeic Acids); 0 (Free Radical Scavengers); 0 (Glycosides); 0 (Hemiterpenes); 0 (Lipopolysaccharides); 0 (Picrates); 31C4KY9ESH (Nitric Oxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:161128
[Lr] Data última revisão:
161128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131029
[St] Status:MEDLINE



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