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Pesquisa : B01.650.940.800.575.912.250.859.937.937.888 [Categoria DeCS]
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[PMID]:29378100
[Au] Autor:Vengerovsky AI; Yakimova TV; Nasanova ON
[Ti] Título:[The influence of nettle and burdock extracts in combination with different diets on dyslipidemia in diabetes mellitus model].
[So] Source:Vopr Pitan;84(6):69-75, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The influence of low-fat diet, nettle (Urtica dioica) leafs and burdock (Arctium lappa) roots extracts on lipid metabolism and glycosylation reactions has been investigated in experimental diabetes mellitus. These extracts were applied in diets with both high and low fat content. The experiments were performed on 90 noninbred male albino rats (200­220 g) that were divided into 9 experimental groups. Diabetes mellitus was modeled with twice-repeated intraperitoneal streptozotocin (30 mg/kg) injections. The animals received food with increased fat content (proteins ­ 8%, fats ­ 30%, carbohydrates ­ 62% of total daily caloric content) during 4 weeks before streptozotocine injections and 8 weeks after its discontinuation. Simultaneously the rats were daily administered nettle leafs (100 mg/kg), burdock roots (25 mg/kg) extracts or metformin (100 mg/kg) into the stomach during 10 days. During the period of agents introduction half the animals continued to receive food with high fat content, the other half received low fat diet (proteins ­ 20%, fats ­ 8%, carbohydrates ­ 72% of the total daily caloric content). The forth (control) group received low fat food only without extracts or metformin administration. The levels of blood glucose, glycosylated hemoglobin, malonic dialdehyde, lipid and lipoprotein fractions content were measured. It has been shown that after streptozotocine injections and 30% fat diet consumption the blood glucose level increased by 5.3 fold compared to that of the intact animals, the content of atherogenic lipid fractions increased by 2­8.3 fold and the protein glycosylation reactions were intensified by 1.9­2.5 fold. In animals fed with 8% fat diet the blood glucose and malonic dialdehyde content decreased by 1.8­2.3 fold. In this experiment the levels of triglycerides, total cholesterol, cholesterol of nonhigh-density lipoproteins, low-density and very low-density lipoproteins, as well as the cholesterol and protein content of high-density lipoproteins normalized. The low fat food did not cause glycosylation reactions regression. With the administration of nettle, burdock extracts or metformin to animals that continued to receive high fat food the blood glucose, triglycerides, total cholesterol, cholesterol of nonhigh-density lipoproteins, low-density and very low-density lipoproteins levels decreased by l.6­7.l fold as compared to the parameters in streptozotocine diabetes mellitus. Cholesterol and protein content of high-density lipoproteins increased by l.4­3.7 fold. The herbal extracts also prevented malonic dialdehyde formation, high-density lipoproteins and hemoglobin glycosylation. The nettle and burdock extracts more effectively decreased hyperglycemia, hypertriglyceridemia and lipoperoxidation in animals fed with low fat food. Metformin in the experiment with low fat intake decreased the glucose, low-density and very low-density lipoproteins content to a maximal degree and prevented high-density lipoproteins glycosylation.
[Mh] Termos MeSH primário: Arctium/química
Diabetes Mellitus Experimental
Dislipidemias
Extratos Vegetais/farmacologia
Urtica dioica/química
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/tratamento farmacológico
Dislipidemias/sangue
Dislipidemias/tratamento farmacológico
Hemoglobina A Glicada/metabolismo
Masculino
Malondialdeído/sangue
Camundongos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:28573249
[Au] Autor:Koçasli S; Demircan Z
[Ad] Endereço:Yildirim Beyazit Universitesi Ankara, Turkey.
[Ti] Título:HERBAL PRODUCT USE BY THE CANCER PATIENTS IN BOTH THE PRE AND POST SURGERY PERIODS AND DURING CHEMOTHERAPY.
[So] Source:Afr J Tradit Complement Altern Med;14(2):325-333, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to evaluate of the use of herbal products in patients in both pre- and post- surgery periods and during chemotherapy, and to determine the factors behind it. MATERIALS AND METHODS: This study was conducted as a descriptive study with 281 patients in 4 centers. The data of the study were collected by using a survey form prepared by the researcher, depending on literature and interview with the participants face-to-face. RESULTS: While the average age of the patients involved in the study is 49.1±12.8, 51.6% of them were females, 34.6% graduate of elementary school, and 34.5% were housewives. While the prevelance of the use of herbal product prior to surgical treatment is 38.9%, it was observed that this rate increased to 54.1% during chemotherapy. It was observed that the most frequently used product was garlic prior to surgical treatment (19.2%), that it was urtica dioica (13.8%) during chemotherapy. Before the surgical treatment, 94.3% of the patients, and during chemotherapy treatment, 81.7% of the patients, stated that the use of herbal product had not been questioned by the physician or nurse. CONCLUSION: Analysis of the results indicates that health professionals need to obtain information regarding the use of herbal products by cancer patients during both pre- and post- surgery periods, as well as during chemotherapy. Patients should be provided with information and guidance about the advantages and disadvantages of using herbal products.
[Mh] Termos MeSH primário: Neoplasias/tratamento farmacológico
Fitoterapia/utilização
Extratos Vegetais
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Antineoplásicos/efeitos adversos
Antineoplásicos/uso terapêutico
Feminino
Alho
Interações Ervas-Drogas
Seres Humanos
Masculino
Meia-Idade
Neoplasias/cirurgia
Enfermeiras e Enfermeiros
Médicos
Fitoterapia/efeitos adversos
Extratos Vegetais/efeitos adversos
Extratos Vegetais/uso terapêutico
Plantas Medicinais
Relações Profissional-Paciente
Urtica dioica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.34


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[PMID]:28544187
[Au] Autor:Franciskovic M; Gonzalez-Pérez R; Orcic D; Sánchez de Medina F; Martínez-Augustin O; Svircev E; Simin N; Mimica-Dukic N
[Ad] Endereço:University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovica 3, 21000, Novi Sad, Serbia.
[Ti] Título:Chemical Composition and Immuno-Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts.
[So] Source:Phytother Res;31(8):1183-1191, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5-O-caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3-O-glucoside) are present in the aerial parts, while lignans (secoisolariciresinol, 9,9'-bisacetyl-neo-olivil and their glucosides) were detected in the root. Herb and root extracts expressed selective inhibition toward cyclooxygenase and lipoxygenase branches in human platelets: root extracts were better at inhibiting thromboxane production, while herb extracts were more specific toward inhibition of 12-lipoxygenase pathway. Stinging nettle extracts mildly increased monocyte chemoattractant protein-1 and growth-related oncogene release from nonstimulated intestinal epithelial cells, stimulating MyD88/NF-κB/p38 signaling, hence preserving the epithelial integrity and enhancing intestinal steady-state defense. Additionally, root extract reduced lipopolysaccharide-induced monocyte chemoattractant protein-1/growth-related oncogene secretion and cyclooxygenase-2 expression in intestinal epithelial cells, thus showing the potential protective effect against tissue damage caused by inflammation processes. These observations suggest that stinging nettle is an interesting candidate for the development of phytopharmaceuticals or dietary supplements for cotreatment of various inflammatory diseases, particularly inflammatory bowel diseases. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Plaquetas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Urtica dioica/química
[Mh] Termos MeSH secundário: Animais
Araquidonato 12-Lipoxigenase/metabolismo
Linhagem Celular
Quimiocina CCL2/metabolismo
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase 2/química
Inibidores de Ciclo-Oxigenase 2/farmacologia
Seres Humanos
Hidroxibenzoatos/química
Lignanas/química
Lignanas/farmacologia
Inibidores de Lipoxigenase/química
Inibidores de Lipoxigenase/farmacologia
Fator 88 de Diferenciação Mieloide/metabolismo
NF-kappa B/metabolismo
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Raízes de Plantas/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCL2 protein, human); 0 (Chemokine CCL2); 0 (Cyclooxygenase 2 Inhibitors); 0 (Hydroxybenzoates); 0 (Lignans); 0 (Lipoxygenase Inhibitors); 0 (MYD88 protein, human); 0 (Myeloid Differentiation Factor 88); 0 (NF-kappa B); 0 (Plant Extracts); 29656-58-4 (phenolic acid); EC 1.13.11.31 (Arachidonate 12-Lipoxygenase); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS2 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5836


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[PMID]:28385108
[Au] Autor:Zemmouri H; Sekiou O; Ammar S; El Feki A; Bouaziz M; Messarah M; Boumendjel A
[Ad] Endereço:a Laboratory of Biochemistry and Environmental Toxicology , Department of Biochemistry, Faculty of Sciences, University of Badji Mokhtar , Annaba , Algeria.
[Ti] Título:Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model.
[So] Source:Pharm Biol;55(1):1561-1568, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use. OBJECTIVE: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract. MATERIALS AND METHODS: Adult male Wistar rats were divided into four groups: Group I: negative control; group II: Ovalbumin sensitized/challenged rats (positive control); group III: received UD extract (1.5 g/kg/day) orally along the experimental protocol; group IV: received UD extract (1.5 g/kg/day) orally along the experimental protocol and sensitized/challenged with ovalbumin. After 25 days, blood and tissue samples were collected for haematological and histopathological analysis, respectively. The oxidative stress parameters were evaluated in the lungs, liver and erythrocytes. Then, correlations between markers of airway inflammation and markers of oxidative stress were explored. RESULTS: UD extract significantly (p < 0.01) inhibited eosinophilia increases in BALF (-60%) and the levels of leucocytes (-32.75%) and lymphocytes (-29.22%) in serum, and effectively suppressed inflammatory cells recruitment in the asthmatic rat model. Besides, the lipid peroxidation generated by allergen administration was significantly (p < 0.05) diminished by UD treatment in lung tissue (-48.58%). The nettle extract was also investigated for the total phenolic content (30.79 ± 0.96 mg gallic acid/g dry extract) and shows DPPH radical scavenging activity with 152.34 ± 0.37 µg/mL IC value. CONCLUSIONS: The results confirmed that UD administration might be responsible for the protective effects of this extract against airway inflammation.
[Mh] Termos MeSH primário: Antiasmáticos/farmacologia
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Asma/prevenção & controle
Peroxidação de Lipídeos/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Ovalbumina
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Pneumonia/prevenção & controle
Urtica dioica/química
[Mh] Termos MeSH secundário: Animais
Antiasmáticos/química
Antiasmáticos/isolamento & purificação
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Asma/induzido quimicamente
Asma/imunologia
Asma/metabolismo
Compostos de Bifenilo/química
Modelos Animais de Doenças
Pulmão/imunologia
Pulmão/metabolismo
Masculino
Fenóis/isolamento & purificação
Fenóis/farmacologia
Fitoterapia
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Plantas Medicinais
Pneumonia/induzido quimicamente
Pneumonia/imunologia
Pneumonia/metabolismo
Eosinofilia Pulmonar/induzido quimicamente
Eosinofilia Pulmonar/metabolismo
Eosinofilia Pulmonar/prevenção & controle
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 9006-59-1 (Ovalbumin); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1310905


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[PMID]:28188411
[Au] Autor:Kornobis FW; Renco M; Filipiak A
[Ad] Endereço:Department of Zoology, Institute of Plant Protection - National Research Institute, Wladyslawa Wegorka 20, 60-318, Poznan, Poland. f.kornobis@onet.eu.
[Ti] Título:First record and description of juvenile stages of Longidorus artemisiae Rubtsova, Chizhov & Subbotin, 1999 (Nematoda: Longidoridae) in Poland and new data on L. juglandicola Lisková, Robbins & Brown, 1997 based on topotype specimens from Slovakia.
[So] Source:Syst Parasitol;94(3):391-402, 2017 Mar.
[Is] ISSN:1573-5192
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper presents the first geographical record of the needle nematode Longidorus artemisiae Rubtsova, Chizhov & Subbotin, 1999 outside Russia. This species was found in Poland near the city of Skierniewice in association with nettle (Urtica dioica L.). Morphometric and morphological data are provided, including the first description of juveniles of this species. Nematodes of the Polish population differ from the type-population in Russia in possessing a thicker body (lower 'a' index) in both sexes; males having a longer body and longer spicules; different sex ratio (1:2 in Polish population vs 1:1 in the type-population) and somewhat less expanded lips. Molecularly, the Polish population was characterised by sequencing D2-D3 28S rDNA and ITS1 markers. Additionally, new data on these two markers are provided for another species, Longidorus juglandicola Lisková, Robbins & Brown, 1997, obtained from topotype specimens from Slovakia. Surprisingly, despite the high morphological similarity of these two species, analysis of their phylogenetic position did not show close phylogenetic relation and several other species (less similar in general morphology) appeared more closely related to both L. artemisiae and L. juglandicola.
[Mh] Termos MeSH primário: Nematoides/classificação
Filogenia
[Mh] Termos MeSH secundário: Animais
DNA Espaçador Ribossômico/genética
Feminino
Masculino
Nematoides/anatomia & histologia
Nematoides/genética
Raízes de Plantas/parasitologia
Polônia
RNA Ribossômico 28S/genética
Eslováquia
Solo/parasitologia
Especificidade da Espécie
Urtica dioica/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer); 0 (RNA, Ribosomal, 28S); 0 (Soil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1007/s11230-017-9703-y


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[PMID]:27389487
[Au] Autor:Aktas C; Erboga M; Fidanol Erboga Z; Bozdemir Donmez Y; Topcu B; Gurel A
[Ad] Endereço:Department of Histology and Embryology, Faculty of Medicine, University of Namik Kemal, Tekirdag, Turkey.
[Ti] Título:Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats.
[So] Source:Andrologia;49(4), 2017 May.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R + UD (2 mg kg ) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted. The structural deterioration in the testicular on I/R group has reduced after the treatment of UD. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end labelling (TUNEL), and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of UD-treated rats in the I/R group. The I/R + UD group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that protective effects of UD on the I/R testicles are via reduction of histological damage, apoptosis, oxidative stress and lipid peroxidation.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Apoptose/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Traumatismo por Reperfusão/tratamento farmacológico
Testículo/efeitos dos fármacos
Urtica dioica/química
[Mh] Termos MeSH secundário: Animais
Catalase/análise
Proliferação Celular
Modelos Animais de Doenças
Glutationa Peroxidase/análise
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Malondialdeído/análise
Antígeno Nuclear de Célula em Proliferação/análise
Ratos
Sementes
Túbulos Seminíferos/anatomia & histologia
Superóxido Dismutase/análise
Testículo/anatomia & histologia
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Proliferating Cell Nuclear Antigen); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1111/and.12636


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[PMID]:28375121
[Au] Autor:Shad AA; Bakht J; Shah HU; Hayat Y
[Ad] Endereço:Department of Agric. Chemistry, The University of Agriculture Peshawar, KPK Pakistan.
[Ti] Título:Antioxidant activity and nutritional assessment of under-utilized medicinal plants.
[So] Source:Pak J Pharm Sci;29(6):2039-2045, 2016 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study investigates the nutritive and anti-nutritive composition of six species (Allium porrum, Amaranthus spinosis, Apium graveolens, Caralluma edulis, Chenopodium album, Urtica dioica). The studied species contained considerable amount of crude protein (4.53-11.41%), crude fat (1.25-3.74%), vitamin C (7.85-28.09mg 100 g) and ß-Carotene (18.29-169.33mg 100 g). The mineral profile of Chenopodium album is considered as potential source of Zn (14.51±1.14mg 100-1g), Mn (67.71±0.85mg 100 g), Se (8.45±0.49mg 100 g) and Fe (182.08±1.52mg 100-1g) and Caralluma edulis as potential source of Fe (7.28± 0.03mg 100 g). Ca and P content ranged 63-306mg 100 g and 12-392mg 100 g in all studied plants with exceptionally high level was found in Chenopodium album (1084mg 100-1g) and (3924mg 100 g), respectively. Similarly, total phenol, tannin and phytic acid were found in the range of 105-354, 5-90 and 10-85mg 100 g, respectively. Total oxalates and soluble oxalates contents were below 200mg 100 g in five examined plants with the exception of Chenopodium album (413mg 100 g). Antioxidant activity of Caralluma edulis was found maximum while the rest of the examined plants had moderate levels.
[Mh] Termos MeSH primário: Amaranthus/química
Antioxidantes/farmacologia
Apium graveolens/química
Apocynaceae/química
Chenopodium album/química
Valor Nutritivo
Cebolas/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Urtica dioica/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Gorduras/análise
Minerais/análise
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Fitoterapia
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Proteínas de Plantas/análise
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Fats); 0 (Minerals); 0 (Phytochemicals); 0 (Picrates); 0 (Plant Extracts); 0 (Plant Proteins); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:27930707
[Au] Autor:Viktorova J; Jandova Z; Madlenakova M; Prouzova P; Bartunek V; Vrchotova B; Lovecka P; Musilova L; Macek T
[Ad] Endereço:UCT Prague, Faculty of Food and Biochemical Technology, Department of Biochemistry and Microbiology, Technicka 3, Prague, Czech Republic.
[Ti] Título:Native Phytoremediation Potential of Urtica dioica for Removal of PCBs and Heavy Metals Can Be Improved by Genetic Manipulations Using Constitutive CaMV 35S Promoter.
[So] Source:PLoS One;11(12):e0167927, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although stinging nettle (Urtica dioica) has been shown to reduce HM (heavy metal) content in soil, its wider phytoremediation potential has been neglected. Urtica dioica was cultivated in soils contaminated with HMs or polychlorinated biphenyls (PCBs). After four months, up to 33% of the less chlorinated biphenyls and 8% of HMs (Zn, Pb, Cd) had been removed. Bacteria were isolated from the plant tissue, with the endophytic bacteria Bacillus shackletonii and Streptomyces badius shown to have the most significant effect. These bacteria demonstrated not only benefits for plant growth, but also extreme tolerance to As, Zn and Pb. Despite these results, the native phytoremediation potential of nettles could be improved by biotechnologies. Transient expression was used to investigate the functionality of the most common constitutive promoter, CaMV 35S in Urtica dioica. This showed the expression of the CUP and bphC transgenes. Collectively, our findings suggest that remediation by stinging nettle could have a much wider range of applications than previously thought.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Engenharia Genética/métodos
Metais Pesados/metabolismo
Plantas Geneticamente Modificadas/metabolismo
Bifenilos Policlorados/metabolismo
Regiões Promotoras Genéticas
Poluentes do Solo/metabolismo
Urtica dioica/metabolismo
[Mh] Termos MeSH secundário: Cádmio/metabolismo
Regulação da Expressão Gênica de Plantas/genética
Chumbo/metabolismo
Metais Pesados/análise
Plantas Geneticamente Modificadas/genética
Bifenilos Policlorados/análise
Regiões Promotoras Genéticas/genética
Solo/química
Urtica dioica/genética
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 2P299V784P (Lead); DFC2HB4I0K (Polychlorinated Biphenyls); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167927


  9 / 239 MEDLINE  
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[PMID]:27925706
[Au] Autor:Wolska J; Czop M; Jakubczyk K; Janda K
[Ad] Endereço:Pomeranian Medical University in Szczecin, Department of Biochemistry and Human Nutrition, Szczecin, Poland
[Ti] Título:Influence of temperature and brewing time of nettle (Urtica dioica L.) infusions on vitamin C content
[So] Source:Rocz Panstw Zakl Hig;67(4):367-371, 2016.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Stinging nettle (Urtica dioica L.) can be found in temperate climate zones of Europe, Africa and America Nettle may be a source of nutritional ingredients, mineral salts, vitamins and antioxidants. Objective: The aim of the study was to determine the effect of temperature and brewing time Urtica dioica L. infusions from different parts of this plant on vitamin C (ascorbic acid) content. Material and methods: Infusions of nettle leaf, stem and root were prepared at room temperature, 50°C, 60°C, 70°C and 80°C for 10 minutes. Leaf infusions were also brewed for 5, 10, 15 and 20 minutes at initial water temperature of 60°C. The amount of vitamin C was determined by the spectrophotometric method. Results: The best temperature of brewing nettle infusions, in terms of vitamin C concentration, is between 50 °C and 60 °C as it is sufficient to extract the substance, yet not high enough to destroy it. Conclusions: The optimal time of brewing appeared to be 10 minutes as the prolonged exposure to high temperature appeared to be detrimental for ascorbic acid as well.
[Mh] Termos MeSH primário: Ácido Ascórbico/análise
Extratos Vegetais/química
Urtica dioica/química
[Mh] Termos MeSH secundário: Europa (Continente)
Folhas de Planta
Raízes de Plantas/química
Caules de Planta/química
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE


  10 / 239 MEDLINE  
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[PMID]:27788883
[Au] Autor:Tiotiu A; Brazdova A; Longé C; Gallet P; Morisset M; Leduc V; Hilger C; Broussard C; Couderc R; Sutra JP; Sénéchal H; Poncet P
[Ad] Endereço:Pneumology-Allergology Department, University Hospital, Nancy, France.
[Ti] Título:Urtica dioica pollen allergy: Clinical, biological, and allergomics analysis.
[So] Source:Ann Allergy Asthma Immunol;117(5):527-534, 2016 Nov.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The most emblematic members of Urticaceae at allergic risk level are wall pellitories (Parietaria), whereas nettle (Urtica) pollen is considered as poorly allergenic. No allergen from nettle pollen has yet been characterized, whereas 4 are listed for Parietaria pollen by the International Union of Immunological Societies. Clinical and biological profiles of 2 adult men who developed symptoms against nettle pollen and/or leaves were studied. OBJECTIVE: To characterize the allergic reaction and identify the potential nettle pollen sensitizing allergens. METHODS: IgE-mediated reaction to nettle pollen extract was evaluated by skin prick test, immunoassay, nasal provocation, and basophil activation test. To characterize specific nettle pollen allergens, an allergomic (IgE immunoproteomic) analysis was performed combining 1- and 2-dimensional electrophoresis, IgE immunoblots of nettle pollen extract, identification of allergens by mass spectrometry, and database queries. RESULTS: The results of biological and immunochemical analyses revealed that the allergic rhinitis was due to Urtica dioica pollen in both patients. The allergomic analysis of nettle pollen extract allowed the characterization of 4 basic protein allergens: a thaumatin-like protein (osmotin) with a relative molecular mass of 27 to 29 kDa, a pectinesterase (relative molecular mass, 40 kDa), and 2 other basic proteins with relative molecular masses of 14 to 16 kDa and 43 kDa. There is no or only very weak allergen associations between pellitory and nettle pollen. CONCLUSION: Exposure to nettle pollen can be responsible of allergic symptoms, and several allergens were characterized. Unravelling the allergens of this underestimated allergy might help to improve diagnosis and care for patients, to predict cross-reactivities and design adapted specific immunotherapy.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Conjuntivite/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/imunologia
Urtica dioica/imunologia
[Mh] Termos MeSH secundário: Conjuntivite/sangue
Seres Humanos
Imunoglobulina E/imunologia
Masculino
Meia-Idade
Testes de Provocação Nasal
Rinite Alérgica Sazonal/sangue
Testes Cutâneos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



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