Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.875.666 [Categoria DeCS]
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[PMID]:28508668
[Au] Autor:Zang YD; Li CJ; Song XY; Ma J; Yang JZ; Chen NH; Zhang DM
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Total synthesis and neuroprotective effect of O-methylmurrayamine A and 7-methoxymurrayacine.
[So] Source:J Asian Nat Prod Res;19(6):623-629, 2017 Jun.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:O-Methylmurrayamine A (7) and 7-methoxymurrayacine (8) are natural products isolated from Murraya koenigii and Murraya siamensis, respectively. In this paper, we report the synthesis of 7 and 8 which are featured in the key step of cyclization to form carbazole intermediate 5 with mild conditions. The structures were confirmed by H NMR, C NMR, and HR-ESI-MS. In addition, compounds 7 and 8 were tested for their neuroprotective effects against H O -induced PC12 cell damage. The results showed that compounds 7 and 8 have neuroprotective effect.
[Mh] Termos MeSH primário: Carbazóis/síntese química
Carbazóis/farmacologia
Fármacos Neuroprotetores/síntese química
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Carbazóis/química
Seres Humanos
Peróxido de Hidrogênio
Estrutura Molecular
Murraya/química
Fármacos Neuroprotetores/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7-methoxymurrayacine); 0 (Carbazoles); 0 (Neuroprotective Agents); 0 (O-methylmurrayamine A); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1327952


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[PMID]:28222592
[Au] Autor:Steinhaus M
[Ad] Endereço:Deutsche Forschungsanstalt für Lebensmittelchemie (German Research Center for Food Chemistry) , Lise-Meitner-Straße 34, 85354 Freising, Germany.
[Ti] Título:Confirmation of 1-Phenylethane-1-thiol as the Character Impact Aroma Compound in Curry Leaves and Its Behavior during Tissue Disruption, Drying, and Frying.
[So] Source:J Agric Food Chem;65(10):2141-2146, 2017 Mar 15.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The most odor-active compounds previously identified by application of an aroma extract dilution analysis were quantitated in freshly picked curry leaves, either by stable isotope dilution assays in combination with GC-GC-MS or by GC-FID after simultaneous extraction/fractionation. Odor activity values (OAVs) were calculated as ratios of concentrations to odor threshold values. The topmost OAVs were obtained for (3Z)-hex-3-enal (grassy; OAV 180 000), (1S)-1-phenylethane-1-thiol (sulfury, burnt; OAV 150 000), (1R)-1-phenylethane-1-thiol (sulfury, burnt; OAV 120 000), (3R)-linalool (citrusy; OAV 58 000), and myrcene (geranium leaf-like; OAV 23 000). The high OAVs calculated for its enantiomers confirmed 1-phenylethane-1-thiol as character impact compound of the typical sulfury and burnt aroma of curry leaves. The 1-phenylethane-1-thiol concentration in curry leaves decreased upon tissue disruption and drying, as well as upon frying of fresh leaves. By contrast, frying of dried leaves led to an increase of 1-phenylethane-1-thiol, indicating a yet unknown thermolabile precursor.
[Mh] Termos MeSH primário: Aromatizantes/química
Manipulação de Alimentos/métodos
Murraya/química
Folhas de Planta/química
Especiarias/análise
Compostos de Sulfidrila/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Odorantes/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavoring Agents); 0 (Sulfhydryl Compounds); 62EE7Q6MB0 (1-phenylethanethiol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00197


  3 / 176 MEDLINE  
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[PMID]:28195475
[Au] Autor:Mondol MA; Farthouse J; Islam MT; Schüffler A; Laatsch H
[Ad] Endereço:Institute for Organic and Biomolecular Chemistry, Georg-August-University Göttingen , Tamannstrasse 2, D-37077 Göttingen, Germany.
[Ti] Título:Metabolites from the Endophytic Fungus Curvularia sp. M12 Act as Motility Inhibitors against Phytophthora capsici Zoospores.
[So] Source:J Nat Prod;80(2):347-355, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The endophytic fungus Curvularia sp., strain M12, was isolated from a leaf of the medicinal plant Murraya koenigii and cultured on rice medium followed by chemical screening of the culture extract. Chromatographic analysis led to the isolation of four new compounds, murranofuran A (1), murranolide A (2), murranopyrone (3a), and murranoic acid A (4a), along with six known metabolites, N-(2-hydroxy-6-methoxyphenyl)acetamide (5), curvularin (6), (S)-dehydrocurvularin (7), pyrenolide A (8), modiolide A (9), and 8-hydroxy-6-methoxy-3-methylisocoumarin (10). The structures of the known compounds were confirmed by comparing ESI HR mass spectra, H and C NMR, and optical rotation data with values reported in the literature. The planar structures of the new compounds were elucidated by extensive analysis of 1D and 2D NMR and mass data. The absolute configurations of the new compounds were established by coupling constant analysis, modified Mosher's method, and CD data. Compound 8 showed a strong motility impairing activity against Phytophthora capsici zoospores at a low concentration (100% at 0.5 µg/mL) in a short time (30 min). Compounds 2, 3a, 6, 7, 9, and 10 exhibited zoospore motility impairment activity at higher concentrations (IC : 50-100 µg/mL).
[Mh] Termos MeSH primário: Ascomicetos/química
Phytophthora/efeitos dos fármacos
[Mh] Termos MeSH secundário: Bangladesh
Relação Dose-Resposta a Droga
Isocumarinas
Estrutura Molecular
Murraya/microbiologia
Ressonância Magnética Nuclear Biomolecular
Folhas de Planta/microbiologia
Plantas Medicinais/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-hydroxy-6-methoxy-3-methylisocoumarin); 0 (Isocoumarins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00785


  4 / 176 MEDLINE  
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[PMID]:28187403
[Au] Autor:Kumar V; Singh DK; Mohan S; Bano D; Gundampati RK; Hasan SH
[Ad] Endereço:Nano Material Research Laboratory, Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, U.P., India.
[Ti] Título:Green synthesis of silver nanoparticle for the selective and sensitive colorimetric detection of mercury (II) ion.
[So] Source:J Photochem Photobiol B;168:67-77, 2017 Mar.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:An ecofriendly and zero cost approach has been developed for the photoinduced synthesis of more stable AgNPs using an aqueous extract of Murraya koenigii (AEM) as a reducing and stabilizing agent. The exposed reaction mixture of AEM and AgNO to sunlight turned dark brown which primarily confirmed the biosynthesis of AgNPs. The biosynthesis was monitored by UV-vis spectroscopy which exhibited a sharp SPR band at 430nm after 30min of sunlight exposure. The optimum conditions for biosynthesis of AgNPs were 30min of sunlight exposure, 2.0% (v/v) of AEM inoculuam dose and 4.0mM AgNO concentration. TEM analysis confirmed the presence of spherical AgNPs with average size 8.6nm. The crystalline nature of the AgNPs was confirmed by XRD analysis where the Bragg's diffraction pattern at (111), (200), (220) and (311) corresponded to face centered cubic crystal lattice of metallic silver. The surface texture was analyzed by AFM analysis where the average roughness of the synthesized AgNPs was found 1.8nm. FTIR analysis was recorded between 4000 and 400cm which confirmed the involvement of various functional groups in the synthesis of AgNPs. On the basis of the linear relationship between SPR band intensity and different concentration of Hg , the synthesized AgNPs can be used for colorimetric detection of Hg with a linear range from 50nm to 500µM. Based on experimental findings, an oxidation-reduction mechanism between AgNPs and Hg was also proposed.
[Mh] Termos MeSH primário: Química Verde/métodos
Mercúrio/análise
Nanopartículas Metálicas/química
Prata/química
[Mh] Termos MeSH secundário: Colorimetria/métodos
Murraya/metabolismo
Oxirredução
Análise Espectral
Luz Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3M4G523W1G (Silver); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:28096658
[Au] Autor:Iman V; Mohan S; Abdelwahab SI; Karimian H; Nordin N; Fadaeinasab M; Noordin MI; Noor SM
[Ad] Endereço:Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Anticancer and anti-inflammatory activities of girinimbine isolated from .
[So] Source:Drug Des Devel Ther;11:103-121, 2017.
[Is] ISSN:1177-8881
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a carbazole alkaloid isolated from , induced apoptosis and inhibited inflammation in vitro as well as in vivo. Induction of apoptosis in human colon cancer cells (HT-29) by girinimbine revealed decreased cell viability in HT-29, whereas there was no cytotoxic effect on normal colon cells. Changes in mitochondrial membrane potential, nuclear condensation, cell permeability, and cytochrome c translocation in girinimbine-treated HT-29 cells demonstrated involvement of mitochondria in apoptosis. Early-phase apoptosis was shown in both acridine orange/propidium iodide and annexin V results. Girinimbine treatment also resulted in an induction of G0/G1 phase arrest which was further corroborated with the upregulation of two cyclin-dependent kinase proteins, p21 and p27. Girinimbine treatment activated apoptosis through the intrinsic pathway by activation of caspases 3 and 9 as well as cleaved caspases 3 and 9 which ended by triggering the execution pathway. Moreover, apoptosis was confirmed by downregulation of Bcl-2 and upregulation of Bax in girinimbine-treated cells. In addition, the key tumor suppressor protein, p53, was seen to be considerably upregulated upon girinimbine treatment. Induction of apoptosis by girinimbine was also evidenced in vivo in zebrafish embryos, with results demonstrating significant distribution of apoptotic cells in embryos after a 24-hour treatment period. Meanwhile, anti-inflammatory action was evidenced by the significant dose-dependent girinimbine inhibition of nitric oxide production in lipopolysaccharide/interferon-gamma-induced cells along with significant inhibition of nuclear factor-kappa B translocation from the cytoplasm to nucleus in stimulated RAW 264.7 cells. Girinimbine was also shown to have considerable antioxidant activity whereby 20 µg/mL of girinimbine was equivalent to 82.17±1.88 µM of Trolox. In mice with carrageenan-induced peritonitis, oral pretreatment with girinimbine helped limit total leukocyte migration (mainly of neutrophils), and reduced pro-inflammatory cytokine levels (interleukin-1beta and tumor necrosis factor-alpha) in the peritoneal fluid. These findings strongly suggest that girinimbine could act as a chemopreventive and/or chemotherapeutic agent by inducing apoptosis while suppressing inflammation. There is a potential for girinimbine to be further investigated for its applicability in treating early stages of cancer.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Murraya/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Citocinas/antagonistas & inibidores
Citocinas/metabolismo
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células HT29
Seres Humanos
Lipopolissacarídeos/antagonistas & inibidores
Lipopolissacarídeos/farmacologia
Camundongos
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Relação Estrutura-Atividade
Células Tumorais Cultivadas
Peixe-Zebra/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antineoplastic Agents, Phytogenic); 0 (Cytokines); 0 (Lipopolysaccharides); 23095-44-5 (girinimbine); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.2147/DDDT.S115135


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[PMID]:27927082
[Au] Autor:Selestino Neta MC; Vittorazzi C; Guimarães AC; Martins JD; Fronza M; Endringer DC; Scherer R
[Ad] Endereço:a Department of Pharmacy , Post-Graduated Program of Pharmaceutical Sciences University Vila Velha , Espírito Santo , Brazil.
[Ti] Título:Effects of ß-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time-kill curve studies.
[So] Source:Pharm Biol;55(1):190-197, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Orange Jessamine [Murraya paniculata L. (Rutaceae)] has been used worldwide in folk medicine as an anti-inflammatory, antibiotic and analgesic. OBJECTIVE: The objective of this study is to investigate the in vitro antioxidant, cytotoxic, antibacterial and antifungal activity and the time-kill curve studies of orange jessamine essential oil and ß-caryophyllene, as well as the chemical composition of the essential oil. MATERIAL AND METHODS: The cytotoxic activity of M. paniculata and ß-caryophyllene (7.8-500 µg/mL) was evaluated using the MTT assay on normal fibroblasts and hepatoma cells. The minimal inhibitory concentration and time-kill curves (24 h) were evaluated against those of Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Enterococcus faecallis, Aspergillus (niger, fumigates and parasiticum) and F. solani by the broth microdilution method. The antioxidant activity was measured by the DPPH and ABTS assays. Chemical composition was evaluated by GC/MS analyses. RESULTS: GC/MS analyses identified 13 compounds, with ß-caryophyllene as the major compound. The oil exhibited moderate antibacterial activity (MIC <1.0 mg/mL) and strong antifungal activity. Time-kill curve studies showed that either the essential oil or ß-caryophyllene presented rapid bacterial killing (4 h for S. aureus) and fungicidal effect (2-4 h for F. solani); however, both displayed weak free radical scavenger capacity. The cytotoxic activity exhibited a prominent selective effect against hepatoma cancer cells (IC value =63.7 µg/mL) compared with normal fibroblasts (IC value =195.0 µg/mL), whereas the ß-caryophyllene showed low cytotoxicity. DISCUSSION AND CONCLUSION: The experimental data suggest that the activities of M. paniculata essential oil are due to the synergistic action among its components.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Carcinoma Hepatocelular/tratamento farmacológico
Fusarium/efeitos dos fármacos
Neoplasias Hepáticas/tratamento farmacológico
Murraya/química
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
Óleos Vegetais/farmacologia
Sesquiterpenos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Fibroblastos/efeitos dos fármacos
Fibroblastos/patologia
Fusarium/crescimento & desenvolvimento
Cromatografia Gasosa-Espectrometria de Massas
Concentração Inibidora 50
Neoplasias Hepáticas/patologia
Camundongos
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Óleos Vegetais/isolamento & purificação
Plantas Medicinais
Sesquiterpenos/isolamento & purificação
Staphylococcus aureus/crescimento & desenvolvimento
Células Swiss 3T3
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils); 0 (Sesquiterpenes); BHW853AU9H (caryophyllene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27680541
[Au] Autor:Utaipan T; Athipornchai A; Suksamrarn A; Jirachotikoon C; Yuan X; Lertcanawanichakul M; Chunglok W
[Ad] Endereço:School of Allied Health Sciences and Public Health, Walailak University, Nakhon Si Thammarat, 80161, Thailand.
[Ti] Título:Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells.
[So] Source:J Nat Med;71(1):158-169, 2017 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Carbazole alkaloids, a major constituent of Murraya koenigii (L.) Sprengel (Rutaceae), exhibit biological effects such as anticancer activity via the induction of apoptosis, and they represent candidate chemotherapeutic agents. Oral squamous cell carcinoma (OSCC) is the most prevalent cancer of the oral cavity and a growing and serious health problem worldwide. In this study, we investigated the anticancer properties and mechanisms of action of two carbazole alkaloids derived from M. koenigii leaves, mahanine and isomahanine, in the OSCC cell line CLS-354. At 15 µM, mahanine and isomahanine were cytotoxic to CLS-354 cells, triggering apoptosis via caspase-dependent and -independent mechanisms. Autophagosomes, visualised using monodansylcadaverine (MDC) labelling, were numerous in carbazole alkaloid-treated cells. Mahanine and isomahanine markedly induced the expression of the autophagosome marker microtubule-associated protein 1 light chain 3, type II (LC3B-II). Genetic and chemical inhibition of autophagy via silencing of the Autophagy protein 5 gene and exposure to bafilomycin A1 (BafA1), respectively, did not arrest carbazole alkaloid-induced apoptosis, indicating that it occurs independently of autophagic activation. Surprisingly, both carbazole alkaloids caused increased accumulation of p62/sequestosome1 (p62/SQSTM1), with coordinated expression of LC3B-II and cleaved caspase-3, suggesting inhibition of autophagic flux. Our results suggest that inhibition of autophagic flux is associated with carbazole alkaloid-induced apoptosis. Our findings provide evidence of a novel cytotoxic action of natural carbazole alkaloids and support their use as candidate chemotherapeutic agents for the treatment of OSCC.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Medicina Herbária/métodos
Neoplasias Bucais/tratamento farmacológico
Murraya/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Alcaloides
Apoptose
Carcinoma de Células Escamosas
Linhagem Celular Tumoral
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-1045-6


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[PMID]:27663177
[Au] Autor:Jagtap S; Khare P; Mangal P; Kondepudi KK; Bishnoi M; Bhutani KK
[Ad] Endereço:Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India.
[Ti] Título:Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations.
[So] Source:Biofactors;43(2):220-231, 2017 Mar.
[Is] ISSN:1872-8081
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Spices and condiments, small but an integral part of the daily diet, are known to affect physiological functions. This study evaluated the effects of mahanimbine, a major carbazole alkaloid from Murraya koenigii (curry leaves), against progression of high-fat diet (HFD)-induced metabolic complications in mice (male and female). Mahanimbine at 2 mg/kg (HFD + LD) and 4 mg/kg (HFD + HD) of body weight was administered daily along with HFD feeding for 12 weeks. At the end of the study, male HFD + LD and HFD + HD groups showed 51.70 ± 3.59% and 47.37 ± 3.73% weight gain, respectively, as compared with 71.02 ± 6.04% in HFD fed mice whereas female HFD + LD and HFD + HD groups showed 24.31 ± 1.68% and 25.10 ± 2.61% weight gain as compared with HFD group with 36.69 ± 3.60% of weight gain. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Moreover, mahanimbine treatment improved glucose clearance and upregulated the expression of insulin responsive genes in liver and adipose tissue. Male and female mice showed different traits in development of HFD-induced metabolic disturbances; however, mahanimbine treatment exerted similar effects in both the sexes. In addition, mahanimbine lowered the absorption of dietary fat resulting in dietary fat excretion. In conclusion, daily consumption of mahanimbine and thereby curry leaves may alleviate development of HFD-induced metabolic alterations. © 2016 BioFactors, 43(2):220-231, 2017.
[Mh] Termos MeSH primário: Carbazóis/administração & dosagem
Compostos Heterocíclicos de 4 ou mais Anéis/administração & dosagem
Hiperlipidemias/tratamento farmacológico
Inflamação/tratamento farmacológico
Obesidade/tratamento farmacológico
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Adiposidade/efeitos dos fármacos
Animais
Carbazóis/química
Dieta Hiperlipídica/efeitos adversos
Feminino
Compostos Heterocíclicos de 4 ou mais Anéis/química
Seres Humanos
Hiperlipidemias/etiologia
Hiperlipidemias/patologia
Inflamação/etiologia
Inflamação/metabolismo
Inflamação/patologia
Insulina/metabolismo
Resistência à Insulina/genética
Masculino
Camundongos
Murraya/química
Obesidade/etiologia
Obesidade/patologia
Folhas de Planta/química
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbazoles); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Insulin); 0 (mahanimbine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE
[do] DOI:10.1002/biof.1333


  9 / 176 MEDLINE  
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[PMID]:27982755
[Au] Autor:Ismail A; Noolu B; Gogulothu R; Perugu S; Rajanna A; Babu SK
[Ad] Endereço:1 Department of Endocrinology & Metabolism, National Institute of Nutrition , Hyderabad, India .
[Ti] Título:Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from Murraya koenigii Leaves in Breast Cancer Cells-Molecular Docking Studies.
[So] Source:J Med Food;19(12):1155-1165, 2016 Dec.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Murraya koenigii (curry tree) leaves are rich in bioactive compounds such as flavonoids, alkaloids, and coumarins. Alkaloids from M. koenigii leaves have antianalgesic, antiulcerogenic, antiobesity, and antitumor activities. In this study, we tested the cytotoxic and proteasome-inhibitory potential of a total alkaloid extract (TAE) from M. koenigii leaves in the breast cancer cell line MDA-MB-231. The TAE decreased cell viability with an IC of 14.4 µg/mL and altered growth kinetics of breast cancer cells. TAE (32 µg/mL) arrested cells (35%) in the "S" phase of the cell cycle and induced apoptosis. The 26S proteasome, a multicatalytic protease complex, promotes tumor cell proliferation and protects tumor cells from apoptosis. The TAE and mahanine, a carbazole alkaloid present in M. koenigii leaves, preferentially inhibited the trypsin-like, but not the chymotrypsin-like proteolytic activity of the proteasome with an IC of 162 µg/mL and 287 µM, respectively. In silico analysis of 26 compounds from M. koenigii leaves revealed significant docking scores for mahanine and two other carbazole alkaloids with the ß2 and ß5 subunits of the catalytic 20S proteasome. Taken together, this study demonstrates that inhibition of the proteasome is an important biological activity of M. koenigii alkaloids, which may lead to cancer cell death.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Neoplasias da Mama/tratamento farmacológico
Simulação de Acoplamento Molecular
Murraya
Extratos Vegetais/farmacologia
Inibidores de Proteassoma/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos
Apoptose/efeitos dos fármacos
Neoplasias da Mama/patologia
Carbazóis/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Folhas de Planta/química
Complexo de Endopeptidases do Proteassoma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Carbazoles); 0 (Plant Extracts); 0 (Proteasome Inhibitors); 0 (mahanine); EC 3.4.25.1 (Proteasome Endopeptidase Complex)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27902410
[Au] Autor:Ganesh PS; Rai RV
[Ad] Endereço:1​Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India.
[Ti] Título:Inhibition of quorum-sensing-controlled virulence factors of Pseudomonas aeruginosa by Murraya koenigii essential oil: a study in a Caenorhabditis elegans infectious model.
[So] Source:J Med Microbiol;65(12):1528-1535, 2016 Dec.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The global emergence of antibiotic-resistant strains of Pseudomonas aeruginosa poses a major threat in both hospital environments and the community. P. aeruginosa is an opportunistic human pathogen, and it also infects a wide range of model organisms including the nematode Caenorhabditis elegans. Quorum sensing (QS) mediates cell-to-cell communication in bacteria and has an important role in regulating virulence genes, antibiotic resistance and biofilm formation, which are crucial for establishment of the infection. Expression of many virulence factors such as pyocyanin and proteases in P. aeruginosa is under the control of the QS system, and are mediated by small molecules such as acyl homoserine lactones. Thus, interfering with the QS system would provide alternative ways of controlling the pathogenicity. Murraya koenigii is a medicinal plant widely used in India. The present study investigated the in vivo inhibitory activity of M. koenigii essential oil (EO) on QS-controlled virulence factors of P. aeruginosa PAO1 using C. elegans. M. koenigii EO significantly inhibited the pyocyanin production and staphylolytic LasA activity of P. aeruginosa PAO1. As compared to the control group with 100 % killing of C. elegans, M. koenigii EO was able to rescue an average of 60 % of C. elegans from death due to the toxic effect of P. aeruginosa. Thus, the present study suggests the anti-QS potential of M. koenigii EO which therefore can be considered as a future therapeutic agent for management of P. aeruginosa-mediated infections.
[Mh] Termos MeSH primário: Caenorhabditis elegans/microbiologia
Murraya/química
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
Pseudomonas aeruginosa/efeitos dos fármacos
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Biofilmes/efeitos dos fármacos
Modelos Animais de Doenças
Seres Humanos
Índia
Infecções por Pseudomonas/tratamento farmacológico
Infecções por Pseudomonas/microbiologia
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Virulence Factors)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000385



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