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[PMID]:28638868
[Au] Autor:Martínez-Pérez EF; Hernández-Terán F; Serrano-Gallardo LB
[Ad] Endereço:Centro de Investigación Biomédicas (CIBM), Universidad Autónoma de Coahuila, Facultad de Medicina, Torreón, Coahuila, México.
[Ti] Título:IN VIVO EFFECT OF EXTRACT ON HEPATIC CYTOCHROME 3A1 IN RATS.
[So] Source:Afr J Tradit Complement Altern Med;14(4):62-68, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Since the time when drugs began to be used, it became evident that they could produce a therapeutic effect, but also a clinical condition of toxicity or no effect at all on humans, despite using the same doses in different patients. Such untoward effects were termed "drug idiosyncrasy" and also "idiosyncratic drug effects", but the factors producing such diverse responses were never taken into account. MATERIALS AND METHODS: L. (fringed rue) is an herbaceous plant of the Rutaceae family used in traditional medicine due to its properties, such as its analgesic and antipyretic effects. This study used 25 male rats divided into five groups. Plant extract was administered to Groups 1 and 2 at doses of 100 and 30 mg/kg/day, respectively, for three days; Group 3 was administered 100 mg/kg/day of dexamethasone (DEX), as well as 100 mg/kg/day of extract; Group 4 was administered 100 mg/kg/day of DEX and treated as positive control; Group 5 was treated as negative control and was administered a physiological solution. Twenty-four hours after the the last dose, the animals were sacrificed and their livers were extracted. RESULTS: The aqueous extract of , intraperitoneally administered, was able to induce cytochrome 3A1 in doses of 30 mg/kg/day, and a greater inducing effect occurs when the plant is co-administered in doses of 100 mg/kg/day with dexamethasone. CONCLUSION: This study suggests that aqueous extract of can induce cytochrome 3a1. This study helps provide a better understanding of CYP3a regulation. Future work is needed to determine the compounds that produce the cytochrome modulation.
[Mh] Termos MeSH primário: Citocromos a3/metabolismo
Fígado/metabolismo
Extratos Vegetais/administração & dosagem
Ruta/química
[Mh] Termos MeSH secundário: Animais
Fígado/efeitos dos fármacos
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytochromes a3); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.8


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[PMID]:28093914
[Au] Autor:Lin Y; Wang Q; Gu Q; Zhang H; Jiang C; Hu J; Wang Y; Yan Y; Xu J
[Ad] Endereço:Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, People's Republic of China.
[Ti] Título:Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication.
[So] Source:J Nat Prod;80(1):53-60, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:(+)-Rutamarin inhibits EBV lytic DNA replication with an IC of 7.0 µM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin. Altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. Of these, 16 compounds (2a-e, 3b-e, 3g, 4f, 4k, 4m-p) were found to be more potent against EBV lytic DNA replication than (-)-chalepin. Compounds 4m, 4n, and 4p exhibited IC values of 1.5, 0.32, and 0.83 µM and showed selectivity index values (SI) of 801, 211, and >120, respectively. Thus, compounds 4m, 4n, and 4p are considered promising leads for further laboratory investigation.
[Mh] Termos MeSH primário: Antivirais/síntese química
Antivirais/isolamento & purificação
Antivirais/farmacologia
Benzopiranos/síntese química
Benzopiranos/isolamento & purificação
Benzopiranos/farmacologia
Replicação do DNA/efeitos dos fármacos
Furocumarinas/isolamento & purificação
Furocumarinas/farmacologia
Herpesvirus Humano 4/efeitos dos fármacos
Ruta/química
Replicação Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Furocumarinas/química
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Benzopyrans); 0 (Furocoumarins); 13164-04-0 (chalepin); 14882-94-1 (rutamarin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00415


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[PMID]:27925496
[Au] Autor:Khadhri A; Bouali I; Belkhir S; Mokded R; Smiti S; Falé P; Araújo ME; Serralheiro ML
[Ad] Endereço:a Faculty of Sciences, Unity of Research of Vegetal Ecology , University of El-Manar II , Tunis , Tunisia.
[Ti] Título:In vitro digestion, antioxidant and antiacetylcholinesterase activities of two species of Ruta: Ruta chalepensis and Ruta montana.
[So] Source:Pharm Biol;55(1):101-107, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Ruta genus (Rutaceae) is abundantly used and described in the most ancient systematic records of medical practice of the Mediterranean world. In Tunisia, this genus is represented by two medicinal and aromatic shrubs: Ruta chalepensis L. and Ruta montana L. OBJECTIVE: This study investigates the antioxidant and acetylcholinesterase inhibition (AChE) activities before and after in vitro gastrointestinal metabolism of leaf decoction of R. chalepensis and R. montana. MATERIALS AND METHODS: We study, in vitro, the effect of the gastrointestinal juices gastric (1.75 mL) or pancreatic (2.5 mL) juices, on the biological activity by the measurement of the antioxidant activity and AChE inhibition during 4 h of decoction extract obtained from the leaves of the two species of Ruta. RESULTS: The results showed that the ability to inhibit the AChE enzyme was similar; being the greatest inhibitory activity exhibited by the ethanol extract (IC = 12 ± 1.1 µg/mL) obtained from leaves of R. chalepensis. CONCLUSION: In conclusion, we showed that there was no appreciable degradation and that the activity was kept constant after gastric and pancreatic juice digestion.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Inibidores da Colinesterase/farmacologia
Digestão
Fármacos Gastrointestinais/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Ruta/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Inibidores da Colinesterase/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Estabilidade de Medicamentos
Suco Gástrico/química
Fármacos Gastrointestinais/isolamento & purificação
Ferro/química
Oxirredução
Suco Pancreático/química
Fitoterapia
Picratos/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Plantas Medicinais
Ruta/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Cholinesterase Inhibitors); 0 (Gastrointestinal Agents); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); E1UOL152H7 (Iron)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE


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[PMID]:27738859
[Au] Autor:Nakano D; Ishitsuka K; Matsuda N; Kouguchi A; Tsuchihashi R; Okawa M; Okabe H; Tamura K; Kinjo J
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
[Ti] Título:Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens.
[So] Source:J Nat Med;71(1):170-180, 2017 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:During the course of our studies towards the identification of promising chemotherapeutic candidates from plants against two human T-cell lymphotropic virus type I-infected T-cell lines (MT-1 and MT-2), we screened 17 extracts from 9 rutaceous plants against MT-1 and MT-2 cells. The extracts from the aerial parts and roots of Boenninghausenia japonica, as well as the leaves and roots of Ruta graveolens showed potent antiproliferative effects. After activity-guided fractionation, we isolated 44 compounds from two rutaceous plants, including three new compounds (1-3), which were classified into 26 coumarin analogs (13 coumarins, 8 furanocoumarins, 4 dihydrofuranocoumarins and one dihydropyranocoumarin), 15 alkaloid analogs (7 quinolone alkaloids, 4 acridone alkaloids, 3 furanoquinoline alkaloids and one tetrahydroacridone alkaloid) and 3 flavonoid glycosides. Structure-activity relationship studies were also evaluated. The coumarin compounds (2, 3 and 7-9) bearing a 3-dimethylallyl moiety showed potent activity. Similarly, of all the furanocoumarins evaluated in the current study, compound 17 bearing a 3-dimethylallyl group also showed potent activity. A dihydrofuranocoumarin (27) bearing a 3-dimethylallyl moiety showed the most potent activity. Following 27, compound 28 showed potent activity. These results therefore suggested that the presence of a 3-dimethylallyl moiety was important to the antiproliferative activity of these coumarin analogs.
[Mh] Termos MeSH primário: Alcaloides/química
Cumarínicos/química
Furocumarinas/química
Leucemia-Linfoma de Células T do Adulto/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Ruta/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Extratos Vegetais/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Furocoumarins); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-1046-5


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[PMID]:27914569
[Au] Autor:Karp JC; Sanchez C; Guilbert P; Mina W; Demonceaux A; Curé H
[Ad] Endereço:Centre Hospitalier de Troyes, 101, Avenue Anatole France, 10000 Troyes, France. Electronic address: jckarp001@rss.fr.
[Ti] Título:Treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may reduce joint pain and stiffness linked to aromatase inhibitors in women with early breast cancer: results of a pilot observational study.
[So] Source:Homeopathy;105(4):299-308, 2016 Nov.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the possible effect of two homeopathic medicines, Ruta graveolens 5CH and Rhus toxicodendron 9CH, in the prevention of aromatase inhibitor (AI) associated joint pain and/or stiffness in women with early, hormone-receptor positive, breast cancer. METHODS: This prospective, unrandomized observational study was carried out between April and October 2014. Women were recruited in two groups, according to which of the two study centres they attended: one receiving homeopathy in addition to standard treatment (group H) and a control group, receiving standard treatment (group C). All women were treated with an AI. In addition, women in group H also took Ruta graveolens 5CH and Rhus toxicodendron 9CH (5 granules, twice a day) up to 7 days before starting AI treatment. The homeopathic medicines were continued for 3 months. Demographic and clinical data were recorded using a self-assessment questionnaire at inclusion (T0) and 3 months (T3). Primary evaluation criteria were the evolution of scores for joint pain and stiffness, the impact of pain on sleep and analgesic consumption in the two groups after 3 months of treatment. RESULTS: Forty patients (mean age 64.9±8.1 years) were recruited, 20 in each group. Two-thirds of the patients had joint pain before starting AI treatment. There was a significant difference in the evolution of mean composite pain score between T0 and T3 in the two groups (-1.3 in group H vs. +3.4 in group C; p=0.0001). The individual components of the pain score (frequency, intensity and number of sites of pain) also decreased significantly in group H. Nine patients in group C (45%) vs. 1 (5%) in group H increased their analgesic consumption between T0 and T3 (p=0.0076). After 3 months of treatment, joint pain had a worse impact on sleep in patients in group C (35% vs. 0% of patients; p=0.0083). The differences observed in the evolution of morning and daytime stiffness between the two groups were smaller (p=0.053 and p=0.33, respectively), with the exception of time necessary for the disappearance of morning stiffness which was greater in group C (37.7±23.0 vs. 17.9±20.1 min; p=0.0173). CONCLUSION: These preliminary results suggest that treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may decrease joint pain/stiffness in breast cancer patients treated with AIs. A larger-scale randomized study is required to confirm these results.
[Mh] Termos MeSH primário: Inibidores da Aromatase/efeitos adversos
Artralgia/tratamento farmacológico
Neoplasias da Mama/tratamento farmacológico
Homeopatia
Fitoterapia
Ruta/química
Toxicodendron/química
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Analgésicos/uso terapêutico
Feminino
Seres Humanos
Meia-Idade
Projetos Piloto
Estudos Prospectivos
Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Analgesics); 0 (Aromatase Inhibitors)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27729078
[Au] Autor:Richardson JS; Sethi G; Lee GS; Malek SN
[Ad] Endereço:Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells.
[So] Source:BMC Complement Altern Med;16(1):389, 2016 Oct 12.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cancer has been one of the leading causes of mortality in this era. Ruta angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic, emmenagogue and ophthalmic. In Malaysia and Singapore, the local Chinese community used it for the treatment of cancer. METHODS: In this study, the methanol and fractionated extracts (hexane, chloroform, ethyl acetate and water) of R. angustifolia were tested for its cytotoxicity using the sulforhodamide (SRB) cytotoxicity assay against HCT-116, A549, Ca Ski and MRC5 cell lines. Chemical isolation was carried out by using the high performance liquid chromatography (HPLC) and the isolated compounds were tested for its cytotoxicity against A549 cell line. Cellular and nuclear morphological changes were observed in the cells using phase contrast microscopy and Hoechst/PI fluorescent staining. The externalisation of phosphatidylserine was observed through FITC-labelling Annexin V/PI assay whilst DNA fragmentation was observed through the TUNEL assay. Other indication of apoptosis occuring through the mitochondrial pathway were the attenuation of mitochondrial membrane potential and increase in ROS production. Activation of caspase 9 and 3 were monitored. Western blot analysis was done to show the expression levels of apoptotic proteins. RESULTS: The chloroform extract (without chlorophyll) exhibited the highest cytotoxic activity with IC of 10.1 ± 0.15 µg/ml against A549 cell line. Further chemical investigation was thus directed to this fraction which led to the isolation of 12 compounds identified as graveoline, psoralen, kokusaginine, methoxysalen, bergapten, arborinine, moskachan B, chalepin, moskachan D, chalepensin, rutamarin and neophytadiene. Among these compounds, chalepin exhibited excellent cytotoxicity against A549 cell line with an IC value of 8.69 ± 2.43 µg/ml (27.64 µM). In western blot analysis, expression of p53, truncated Bid, Bax and Bak while the anti-apoptotic proteins Bcl-2, survivin, XIAP, Bcl-X ,cFLIP decreased in a time-dependent manner when A549 cells were treated with 36 µg/ml of chalepin. In addition, the level of PARP was found to decrease. CONCLUSION: Hence these findings indicated that chalepin-induced cell death might involve the intrinsic mitochodrial pathway resulting in the upregulation of pro-apoptotic proteins and downregulation of anti-apoptotic proteins. Thus, chalepin could be an excellent candidate for the development of an anticancer agent.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Furocumarinas/farmacologia
Neoplasias Pulmonares
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Extratos Vegetais/química
Ruta/química
[Mh] Termos MeSH secundário: Caspases/metabolismo
Linhagem Celular Tumoral
Furocumarinas/química
Furocumarinas/isolamento & purificação
Seres Humanos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furocoumarins); 0 (Plant Extracts); 13164-04-0 (chalepin); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


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[PMID]:27653470
[Au] Autor:Faria JM; Rodrigues AM; Sena I; Moiteiro C; Bennett RN; Mota M; Figueiredo AC
[Ad] Endereço:Centro de Estudos do Ambiente e do Mar Lisboa, Faculdade de Ciências, Universidade de Lisboa, CBV , C2, Piso 1, Campo Grande, 1749-016 Lisboa, Portugal.
[Ti] Título:Bioactivity of Ruta graveolens and Satureja montana Essential Oils on Solanum tuberosum Hairy Roots and Solanum tuberosum Hairy Roots with Meloidogyne chitwoodi Co-cultures.
[So] Source:J Agric Food Chem;64(40):7452-7458, 2016 Oct 12.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As a nematotoxics screening biotechnological system, Solanum tuberosum hairy roots (StHR) and S. tuberosum hairy roots with Meloidogyne chitwoodi co-cultures (StHR/CRKN) were evaluated, with and without the addition of the essential oils (EOs) of Satureja montana and Ruta graveolens. EOs nematotoxic and phytotoxic effects were followed weekly by evaluating nematode population density in the co-cultures as well as growth and volatile profiles of both in vitro cultures types. Growth, measured by the dissimilation method and by fresh and dry weight determination, was inhibited after EO addition. Nematode population increased in control cultures, while in EO-added cultures numbers were kept stable. In addition to each of the EOs main components, and in vitro cultures constitutive volatiles, new volatiles were detected by gas chromatography and gas chromatography coupled to mass spectrometry in both culture types. StHR with CRKN co-cultures showed to be suitable for preliminary assessment of nematotoxic EOs.
[Mh] Termos MeSH primário: Óleos Voláteis/farmacologia
Raízes de Plantas/efeitos dos fármacos
Ruta/química
Satureja/química
Solanum tuberosum/parasitologia
Tylenchoidea/patogenicidade
[Mh] Termos MeSH secundário: Animais
Técnicas de Cocultura
Cromatografia Gasosa-Espectrometria de Massas
Óleos Voláteis/análise
Óleos Voláteis/química
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/parasitologia
Solanum tuberosum/citologia
Solanum tuberosum/efeitos dos fármacos
Tylenchoidea/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27649128
[Au] Autor:Apostolico I; Aliberti L; Caputo L; De Feo V; Fratianni F; Nazzaro F; Souza LF; Khadhr M
[Ad] Endereço:Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy. i.apostolico1@studenti.unisa.it.
[Ti] Título:Chemical Composition, Antibacterial and Phytotoxic Activities of Peganum harmala Seed Essential Oils from Five Different Localities in Northern Africa.
[So] Source:Molecules;21(9), 2016 Sep 15.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Peganum harmala L., also known as Syrian rue or Pègano, is a herbaceous plant belonging to the Zygohpyllaceae family, and is widely used in traditional medicine. The chemical composition of essential oils of P. harmala seeds from five different regions of Northern Africa (Algeria, Egypt, Libya, Morocco and Tunisia) was studied by GC and GC-MS analyses. A total of 105 compounds were identified, the main components being oxygenated monoterpenes and oxygenated sesquiterpenes. Eugenol is the main component in all oils. The antimicrobial activity of the essential oils was assayed against some bacterial strains: Staphylococcus aureus (DSM 25693), Bacillus cereus (DSM 4313), Bacillus cereus (DSM4384), Escherichia coli (DMS 857) and Pseudomonas aeruginosa (ATCC 50071). All the oils showed different inhibitory activity. In the twentieth century this is an important result; we need possible new botanical drugs because the problem of resistance to antimicrobial drugs has become apparent. Moreover, the essential oils were evaluated for their possible in vitro phytotoxic activity against germination and initial radicle growth of Raphanus sativus L., Lepidium sativum L., and Ruta graveolens L. The results showed that both germination and radical elongation were sensitive to the oils.
[Mh] Termos MeSH primário: Antibacterianos
Bactérias/crescimento & desenvolvimento
Herbicidas
Lepidium sativum/crescimento & desenvolvimento
Óleos Voláteis
Peganum/química
Raphanus/crescimento & desenvolvimento
Ruta/crescimento & desenvolvimento
Sementes/química
[Mh] Termos MeSH secundário: África do Norte
Antibacterianos/química
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Herbicidas/química
Herbicidas/isolamento & purificação
Herbicidas/farmacologia
Óleos Voláteis/química
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Herbicides); 0 (Oils, Volatile)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27592474
[Au] Autor:Saeidinia A; Keihanian F; Delavar SF; Keihanian F; Ranjbar A; Karkan MF
[Ad] Endereço:General Physician, Student Basij Medicinal Plants Research Center, Guilan University of Medical Sciences, Rasht, Iran / Young Researchers Club, Rasht Branch, Islamic Azad University, Rasht, Iran.
[Ti] Título:Lack of antibacterial activity of Ruta graveolens extracts against Enterococcus fecalis.
[So] Source:Pak J Pharm Sci;29(4 Suppl):1371-4, 2016 Jul.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Enterococcus fecalis is responsible for majority of enterococci infections and can cause clinical disorders in adult and pediatrics. In order to adverse effects of synthetic drugs, it has made a positive attitude toward alternative and complementary medicine. Ruta graveolens has a wide therapeutic application for various diseases. Aim of this study was to see the effect of this herb on Enterococcus fecalis growth. In this investigation we used standard Enterococcus fecalis. Effect of hydro-alcoholic, aqueous and methanolic extracts of Ruta graveolens on growth of bacteria has been evaluated by disc diffusion and serial dilution method and compared with eight prevalent antibiotics. None of disks with different extracts in the range of 50 to 400µ/ µl show any non-growth hallo. Disks with 500µg of all type extracts in comparison with antibiotic disks did not avoid from growth of bacteria. Third test showed the growth of bacteria and ineffectiveness of various amount of extracts. It seems that this ineffectiveness is because of low antibacterial substance against the bacteria in extracts of the herb and high resistant nature of Enterococcus fecalis to antibiotics and it needs more studies.
[Mh] Termos MeSH primário: Enterococcus faecalis/efeitos dos fármacos
Extratos Vegetais/farmacologia
Ruta/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana
Testes de Sensibilidade Microbiana
Óleos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160905
[St] Status:MEDLINE


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Fotocópia
[PMID]:27272785
[Au] Autor:Schelz Z; Ocsovszki I; Bózsity N; Hohmann J; Zupkó I
[Ad] Endereço:Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
[Ti] Título:Antiproliferative Effects of Various Furanoacridones Isolated from Ruta graveolens on Human Breast Cancer Cell Lines.
[So] Source:Anticancer Res;36(6):2751-8, 2016 Jun.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Thanks to its biologically active constituents, Ruta graveolens L. (Rutaceae) is a widely used medicinal plant. In our study, six furanoacridone alkaloids isolated from Ruta graveolens were investigated for their antiproliferative and pro-apoptotic effects on human breast cancer cell lines (MCF-7, MDA-MB-361, MDA-MB-231 and T47D). MATERIALS AND METHODS: The cell lines were pretreated with alkaloid components (rutacridone, isogravacridone chlorine (IGC), gravacridonediol monomethyl ether, gravacridonediol, gravacridonetriol, a 1:1 mixture of gravacridonetriol and - diol monoglucosides) and their antiproliferative effects were determined by the MTT assay. RESULTS: IGC had the most marked effect on cell proliferation of MDA-MB-231 (half maximal inhibitory concentration (IC50)=2.27 µM). Cell-cycle analysis was applied to quantify the effect of IGC on subpopulations of MDA-MB-231 and MCF-7 cells. It caused a cell-cycle disturbance by decreasing the G2/M and G0/G1 and increasing the S phase and the appearance of the subdiploid (sub-G1) population. Hoechst 33258-propidium iodide staining was used to evaluate the morphological changes in IGC-pretreated MDA-MB-231 and MCF-7 cells, revealing the appearance of apoptotic features. IGC was found to cause a modest activation of caspase-3 and -9, but not caspase-8, indicating the activation of an intrinsic apoptotic pathway in MDA-MB-231 cells. CONCLUSIONS: These in vitro findings indicate that furanoacridones are suitable candidates for anticancer drug development.
[Mh] Termos MeSH primário: Acridonas/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Ruta/química
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Caspases/metabolismo
Ciclo Celular/efeitos dos fármacos
Feminino
Seres Humanos
Células MCF-7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acridones); 0 (Antineoplastic Agents, Phytogenic); 6BK306GUQA (acridone); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE



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