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Pesquisa : B01.650.940.800.575.912.250.882 [Categoria DeCS]
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[PMID]:27863835
[Au] Autor:Farag MA; Fahmy S; Choucry MA; Wahdan MO; Elsebai MF
[Ad] Endereço:Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini St., P.B. 11562, Cairo, Egypt. Electronic address: Mohamed.farag@pharma.cu.edu.eg.
[Ti] Título:Metabolites profiling reveals for antimicrobial compositional differences and action mechanism in the toothbrushing stick "miswak" Salvadora persica.
[So] Source:J Pharm Biomed Anal;133:32-40, 2017 Jan 30.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Among many plant species suitable for preparing toothbrushing sticks, miswak (Salvadora persica, family Salvadoraceae) is found the most effective tool for oral hygiene. S. persica possesses antibacterial, antiviral and antifungal effects against oral microbes, mostly due to its benzyl isothiocyanate content. To provide insight into S. persica chemical composition, volatile constituents from roots and stems of S. persica grown in Egypt and Saudi Arabia were profiled using solid-phase microextraction (SPME) coupled to gas chromatography-mass spectrometry (GC-MS). A total of 21 volatiles were identified with sulfur compounds amounting for the major volatile class. Orthogonal projection to latent structures-discriminant analysis (OPLS-DA) revealed for benzyl isothiocyanate (BITC) enrichment in roots versus stems. Primary metabolites contributing to S. persica taste viz. sugars and organic acids were profiled using GC-MS with silylation. Polyols (sugars) viz. arabitol, meso-erythritol, and mannitol were found to predominate sugars composition in S. persica stems being most enriched in meso-erythritol. The impact of saliva on S. persica aroma profile was further assessed and revealing for no enhancement in BITC production with salivation, and further not being detected in toothpaste preparation claimed to contain S. persica extract. This study provides the most complete profile of volatiles, sugars, and organic acids in S. persica organs and more rationalizing its use as a toothbrush.
[Mh] Termos MeSH primário: Anti-Infecciosos/isolamento & purificação
Extratos Vegetais/química
Salvadoraceae/química
Álcoois Açúcares/isolamento & purificação
Compostos Orgânicos Voláteis/isolamento & purificação
[Mh] Termos MeSH secundário: Anti-Infecciosos/análise
Raízes de Plantas/química
Caules de Planta/química
Saliva/metabolismo
Álcoois Açúcares/análise
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 0 (Sugar Alcohols); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:27659804
[Au] Autor:Elkhateeb A; Abdel Latif RR; Marzouk MM; Hussein SR; Kassem ME; Khalil WK; El-Ansari MA
[Ad] Endereço:a Department of Phytochemistry and Plant Systematics , National Research Center , Dokki , Giza , Egypt.
[Ti] Título:Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl -induced changes in the genetic materials in male rats.
[So] Source:Pharm Biol;55(1):139-145, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Dobera glabra (Forssk.) Poir (Salvadoraceae) is a highly valued tree with diverse importance as special mineral sourced feed and a folkloric tool for forecasting droughts. However, there are no reports on its phytochemical and biological investigations. OBJECTIVE: Phytochemical investigation of D. glabra leaves and its protective potential against CCl inducing changes in the genetic materials. MATERIALS AND METHODS: D. glabra extract, DGE (70% MeOH/H O), was applied to polyamide column chromatography, eluting with MeOH/H O of decreasing polarities, followed by preparative chromatographic tools, yielded seven compounds. Three DGE doses (50, 100 and 200 mg/kg bw/d) were administrated for 8 weeks intragastrically to male albino rats prior treated with CCl (0.5 mL/kg/bw). The reactive oxygen species (ROS) levels, expression changes of glutamate transporters (GLAST, GLT-1 and SNAT3) mRNA, DNA fragmentation and glutathione peroxidase (GPx) activity were investigated in the liver tissues of these rats. RESULTS: Isorhamnetin-3-O-ß-glucopyranoside-7-O-α-rhamnopyranoside, isorhamnetin-3-O-α-rhamnopyranoside-7-O-ß-glucopyranoside, kaempferol-3,7-di-O-α-rhamnopyranoside, isorhamnetin-3-O-ß-glucopyranoside, kaempferol-3-O-ß-glucopyranoside, isorhamnetin and kaempferol were identified. DGE (200 mg/kg bw) + CCl exhibited the most significant reduction in ROS levels and DNA fragmentation with 251.3% and141% compared to 523.1% and 273.2% for CCl , respectively. Additionally, it increased significantly the mRNA expression of GLAST, GLT-1 and SNAT3 to 2.16-, 1.72- and 2.09-fold, respectively. Also, GPx activity was increased to 4.8 U/mg protein/min compared to CCl (1.8 U/mg protein/min). DISCUSSION AND CONCLUSION: Flavonoid constituents, antioxidant effect and genotoxic protection activity of D. glabra were first reported. DGE may be valuable in the treatment and hindrance of hepatic oxidative stress and genotoxicity.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Tetracloreto de Carbono
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Dano ao DNA/efeitos dos fármacos
Flavonoides/farmacologia
Fígado/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Salvadoraceae/química
[Mh] Termos MeSH secundário: Sistemas de Transporte de Aminoácidos Neutros/genética
Sistemas de Transporte de Aminoácidos Neutros/metabolismo
Animais
Antioxidantes/isolamento & purificação
Doença Hepática Induzida por Substâncias e Drogas/genética
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Modelos Animais de Doenças
Transportador 1 de Aminoácido Excitatório/genética
Transportador 1 de Aminoácido Excitatório/metabolismo
Transportador 2 de Aminoácido Excitatório/genética
Transportador 2 de Aminoácido Excitatório/metabolismo
Flavonoides/isolamento & purificação
Glutationa Peroxidase/metabolismo
Fígado/metabolismo
Masculino
Metanol/química
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
RNA Mensageiro/metabolismo
Ratos
Espécies Reativas de Oxigênio/metabolismo
Solventes/química
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acid Transport Systems, Neutral); 0 (Antioxidants); 0 (Excitatory Amino Acid Transporter 1); 0 (Excitatory Amino Acid Transporter 2); 0 (Flavonoids); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 0 (Slc1a2 protein, rat); 0 (Slc1a3 protein, rat); 0 (Solvents); 0 (system N protein 1); CL2T97X0V0 (Carbon Tetrachloride); EC 1.11.1.9 (Glutathione Peroxidase); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


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[PMID]:27965502
[Au] Autor:Mustafa M; AlJeaidi Z; AlAajam WH; Dafaalla Mohammed KA
[Ad] Endereço:Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam bin AbdulAziz University, P.O.Box: 153, AlKharj - 11942 Kingdom of Saudi Arabia, Phone: 00966115886240, e-mail: ma.mustafa@psau.edu.sa.
[Ti] Título:Study of Caries Prevalence among Miswak and Non-Miswak Users: A Prospective Study.
[So] Source:J Contemp Dent Pract;17(11):926-929, 2016 Nov 01.
[Is] ISSN:1526-3711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Various types of oral hygiene measures have been practiced by different populations around the world, as there is difference in the oral hygiene products including toothpicks and toothpowders. Miswak or tooth cleaning stick, for mechanical tooth cleaning, can be traced back at least to pre-Islamic times. Currently, many of the world populations still use chewing sticks as the single method for tooth brushing. The present study was done to study the incidence and prevalence of caries among Miswak and non-Miswak users. MATERIALS AND METHODS: The study was done consisting of 120 cases and 120 control group (60 boys and 60 girls in each group) from the secondary school. The materials used were light, explorer, mirror, gloves, upper and lower teeth models, Miswak, and common toothbrush. After the recording of the primary data, Miswak was given to case group and the students were trained to use it on the teeth models. After 2 years, the examination of the teeth was done using the same method as before start of the study and by the same investigators. All the data were recorded, tabulated, and analyzed with the help of Statistical Package for the Social Sciences (SPSS) statistics version 17 using Student's t-test. RESULTS: From the 240 participants, only 211 had continued the study for the total period of time. Out of these, 111 were from the study group and 100 from the control group. On comparison of the decayed-missing-filled (DMF) index scores of the study and control groups, before and after completion of the study, had also shown that the caries index was increased and the difference was found to be statistically significant. CONCLUSION: From the study, it can be concluded that the study group using Miswak had less number of caries incidence than the control group of non-Miswak. CLINICAL SIGNIFICANCE: Miswak can be used as teeth cleaning aid in day-to-day life as it can reduce the caries incidence.
[Mh] Termos MeSH primário: Cárie Dentária/epidemiologia
Prevalência
Salvadoraceae
Escovação Dentária/instrumentação
Escovação Dentária/métodos
[Mh] Termos MeSH secundário: Criança
Placa Dentária/epidemiologia
Feminino
Seres Humanos
Masculino
Higiene Bucal/instrumentação
Higiene Bucal/métodos
Doenças Periodontais
Fitoterapia
Caules de Planta
Plantas Medicinais
Estudos Prospectivos
Saúde da População Rural
Arábia Saudita
Saúde da População Urbana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE


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Registro de Ensaios Clínicos
[PMID]:27903262
[Au] Autor:Abdulbaqi HR; Himratul-Aznita WH; Baharuddin NA
[Ad] Endereço:Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Evaluation of Salvadora persica L. and green tea anti-plaque effect: a randomized controlled crossover clinical trial.
[So] Source:BMC Complement Altern Med;16(1):493, 2016 Dec 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the author's earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adherence effects against primary plaque colonizers biofilm. A clinical trial was needed to support these preliminary in vitro results and to investigate its efficacy as a mouthwash in the control of dental plaque. METHODS: A 24 h plaque re-growth, double-blinded, randomized crossover trial was carried out. Participants (n = 14) randomly rinsed with test formulation, 0.12% chlorhexidine (control) and placebo mouthwashes for 24 h. A week before the trial, all participants received scaling, polishing and oral hygiene education. On the trial day, the participants received polishing at baseline and rinsed with 15 ml of randomly allocated mouthwash twice daily without oral hygiene measures. After 24 h, plaque index was scored and then the participants entered a 6-days washout period with regular oral hygiene measures. The same protocol was repeated for the next 2 mouthwashes. RESULTS: The results were expressed as mean (±SD) plaque index. The test mouthwash (0.931 ± 0.372) significantly reduced plaque accumulation when compared with placebo (1.440 ± 0.498, p < 0.0167) and chlorhexidine (1.317 ± 0.344, p < 0.0167) mouthwashes. No significant difference was found between chlorhexidine and placebo (p > 0.0167). CONCLUSIONS: The test mouthwash has an anti-plaque effect for a 24 h period. Longer-term clinical studies are highly encouraged to investigate its anti-plaque effect for longer periods. TRIAL REGISTRATION: This study was registered in ClinicalTrials.gov as NCT02624336 in December 3, 2015.
[Mh] Termos MeSH primário: Placa Dentária/tratamento farmacológico
Antissépticos Bucais/uso terapêutico
Extratos Vegetais/uso terapêutico
Salvadoraceae/química
Chá
[Mh] Termos MeSH secundário: Adulto
Estudos Cross-Over
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mouthwashes); 0 (Plant Extracts); 0 (Tea)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:27827968
[Au] Autor:Shaik MR; Albalawi GH; Khan ST; Khan M; Adil SF; Kuniyil M; Al-Warthan A; Siddiqui MR; Alkhathlan HZ; Khan M
[Ad] Endereço:Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. rafiskm@gmail.com.
[Ti] Título:"Miswak" Based Green Synthesis of Silver Nanoparticles: Evaluation and Comparison of Their Microbicidal Activities with the Chemical Synthesis.
[So] Source:Molecules;21(11), 2016 Nov 06.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Microbicidal potential of silver nanoparticles (Ag-NPs) can be drastically improved by improving their solubility or wettability in the aqueous medium. In the present study, we report the synthesis of both green and chemical synthesis of Ag-NPs, and evaluate the effect of the dispersion qualities of as-prepared Ag-NPs from both methods on their antimicrobial activities. The green synthesis of Ag-NPs is carried out by using an aqueous solution of readily available L. root extract (RE) as a bioreductant. The formation of highly crystalline Ag-NPs was established by various analytical and microscopic techniques. The rich phenolic contents of L. RE (Miswak) not only promoted the reduction and formation of NPs but they also facilitated the stabilization of the Ag-NPs, which was established by Fourier transform infrared spectroscopy (FT-IR) analysis. Furthermore, the influence of the volume of the RE on the size and the dispersion qualities of the NPs was also evaluated. It was revealed that with increasing the volume of RE the size of the NPs was deteriorated, whereas at lower concentrations of RE smaller size and less aggregated NPs were obtained. During this study, the antimicrobial activities of both chemically and green synthesized Ag-NPs, along with the aqueous RE of L., were evaluated against various microorganisms. It was observed that the green synthesized Ag-NPs exhibit comparable or slightly higher antibacterial activities than the chemically obtained Ag-NPs.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Nanopartículas Metálicas/química
Extratos Vegetais/farmacologia
Substâncias Redutoras/farmacologia
Salvadoraceae/química
Prata/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Química Verde/métodos
Testes de Sensibilidade Microbiana
Tamanho da Partícula
Extratos Vegetais/química
Raízes de Plantas/química
Substâncias Redutoras/química
Prata/química
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 0 (Reducing Agents); 3M4G523W1G (Silver)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27794161
[Au] Autor:Bin-Shuwaish MS
[Ad] Endereço:Department of Restorative Dental Sciences, College of Dentistry King Saud University, Riyadh, Kingdom of Saudi Arabia, e-mail: malshowaish@ksu.edu.sa.
[Ti] Título:Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review.
[So] Source:J Contemp Dent Pract;17(10):867-879, 2016 Oct 01.
[Is] ISSN:1526-3711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The degree of success in the elimination of bacteria during cavity preparation and prior to the insertion of a restoration may increase the longevity of the restoration and therefore the success of the restorative procedure. The complete eradication of bacteria in a caries-affected tooth, during cavity preparation, is considered a difficult clinical task. In addition to weakening the tooth structure, attempts to excavate extensive carious tissue completely, by only mechanical procedures, may affect the vitality of the pulp. Therefore, disinfection of the cavity preparation after caries excavation can aid in the elimination of bacterial remnants that can be responsible for recurrent caries, postoperative sensitivity, and failure of the restoration. However, the effects of disinfectants on the restorative treatment have been a major concern for dental clinicians and researchers. This review aims to explore existing literature and provide information about different materials and techniques that have been used for disinfecting cavity preparations and their effects and effectiveness in operative dentistry and, therefore, helps dental practitioners with clinical decision to use cavity disinfectants during restorative procedures. Antimicrobial effectiveness and effects on the pulp and dental restorations, in addition to possible side effects, were all reviewed in this paper.
[Mh] Termos MeSH primário: Preparo da Cavidade Dentária
Dentística Operatória
Desinfetantes/farmacologia
Procedimentos Cirúrgicos Bucais
[Mh] Termos MeSH secundário: Compostos de Benzalcônio/farmacologia
Clorexidina/análogos & derivados
Clorexidina/farmacologia
Polpa Dentária/efeitos dos fármacos
Compostos de Iodo/farmacologia
Lasers
Morinda
Oxidantes Fotoquímicos/farmacologia
Ozônio/farmacologia
Extratos Vegetais/farmacologia
Própole
Salvadoraceae
Hipoclorito de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzalkonium Compounds); 0 (Disinfectants); 0 (Iodine Compounds); 0 (Oxidants, Photochemical); 0 (Plant Extracts); 66H7ZZK23N (Ozone); 9009-62-5 (Propolis); DY38VHM5OD (Sodium Hypochlorite); MOR84MUD8E (chlorhexidine gluconate); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


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[PMID]:27585261
[Au] Autor:Miri A; Dorani N; Darroudi M; Sarani M
[Ad] Endereço:Zabol University of Medical Sciences Department of Pharmacognosy, Faculty of Pharmacy Zabol Iran.
[Ti] Título:Green synthesis of silver nanoparticles using Salvadora persica L. and its antibacterial activity.
[So] Source:Cell Mol Biol (Noisy-le-grand);62(9):46-50, 2016 Aug 29.
[Is] ISSN:1165-158X
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The silver nanoparticles (AgNPs) shows special physicochemical properties, therefore they use many applications such as catalysis, health, electronic and optical. In this study, AgNPs was synthesized using aqueous extract of Salvadora persica bark. The synthesized AgNPs were characterized by UV-Vis spectroscopy, Powder X-ray diffraction (PXRD) and Transmission electron microscopy (TEM) methods. The optimal synthesis condition to prepare nanoparticles was determined as silver nitrate 3 mM, 5 ml of aqueous extract in the room temperature for 1 h. The TEM image of AgNPs showed the formation of spherical, non-uniform nanoparticles of mean size of 50 nm. The antibacterial activity of synthesized AgNPs was evaluated using disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods on Escherichia coli and Staphylococcus aureus bacteria. The MIC values of AgNPs were 100 and 400 µg/mL on E. coli and S. aureus, respectively. Also the MBC of AgNPs was 200 µg/mL for E. coli and there was no result observed for S. aureus bacteria. The results showed that synthesized nanoparticles have favorable antibacterial properties.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
Nanopartículas Metálicas/toxicidade
Salvadoraceae/química
Prata/química
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Química Verde
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Transmissão
Tamanho da Partícula
Extratos Vegetais/química
Salvadoraceae/metabolismo
Espectrofotometria Ultravioleta
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE


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Texto completo
[PMID]:27570858
[Au] Autor:Al-Dabbagh SA; Qasim HJ; Al-Derzi NA
[Ad] Endereço:Department of Family and Community Medicine, College of Medicine, University of Duhok, Kurdistan region, Iraq. E-mail. samimaldabbagh@yahoo.com.
[Ti] Título:Efficacy of Miswak toothpaste and mouthwash on cariogenic bacteria.
[So] Source:Saudi Med J;37(9):1009-14, 2016 Sep.
[Is] ISSN:0379-5284
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the efficacy of Salvadora persica (Miswak) products on cariogenic bacteria in comparison with ordinary toothpaste.  METHODS: The study was conducted in Zakho city, Kurdistan region, Iraq during the period from October 2013 to January 2014. A randomized controlled clinical trial of 40 students randomly allocated into 4 groups. They were instructed to use Mismark toothpaste, Miswak mouthwash, and ordinary toothpaste with water or with normal saline. Salivary samples were collected at 3-time intervals: before, immediately after use, and after 2 weeks of use. The effect of each method on Streptococcus mutans and Lactobacilli was evaluated by using caries risk test.  RESULTS: One-way repeated measure analysis of variance (ANOVA), one-way ANOVA, and least significant difference tests were used. Miswak wash has a significant reduction effect on both bacteria immediately and after 2 weeks of use. Miswak paste has a similar effect on Lactobacilli, while Streptococcus mutans showed a significant decrease only after 2 weeks of use. Ordinary paste showed a non significant effect on both bacteria at both time intervals; while the addition of normal saline showed a significant effect on both bacteria only after 2 weeks of use.  CONCLUSION: Miswak products, especially mouth wash, were more effective in reducing the growth of cariogenic bacteria than ordinary toothpaste.
[Mh] Termos MeSH primário: Cárie Dentária/microbiologia
Lactobacillus/efeitos dos fármacos
Antissépticos Bucais/farmacologia
Salvadoraceae
Streptococcus mutans/efeitos dos fármacos
Cremes Dentais/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mouthwashes); 0 (Toothpastes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE
[do] DOI:10.15537/smj.2016.9.15855


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[PMID]:27343694
[Au] Autor:Abdulbaqi HR; Himratul-Aznita WH; Baharuddin NA
[Ad] Endereço:Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
[Ti] Título:Anti-plaque effect of a synergistic combination of green tea and Salvadora persica L. against primary colonizers of dental plaque.
[So] Source:Arch Oral Biol;70:117-124, 2016 Oct.
[Is] ISSN:1879-1506
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Green tea (Gt), leafs of Camellia sinensis var. assamica, is widely consumed as healthy beverage since thousands of years in Asian countries. Chewing sticks (miswak) of Salvadora persica L. (Sp) are traditionally used as natural brush to ensure oral health in developing countries. Both Gt and Sp extracts were reported to have anti-bacterial activity against many dental plaque bacteria. However, their combination has never been tested to have anti-bacterial and anti-adherence effect against primary dental plaque colonizers, playing an initial role in the dental plaque development, which was investigated in this study. METHODS: Two-fold serial micro-dilution method was used to measure minimal inhibitory concentration (MIC) of aqueous extracts of Gt, Sp and their combinations. Adsorption to hexadecane was used to determine the cell surface hydrophobicity (CSH) of bacterial cells. Glass beads were used to mimic the hard tissue surfaces, and were coated with saliva to develop experimental pellicles for the adhesion of the primary colonizing bacteria. RESULTS: Gt aqueous extracts exhibited better anti-plaque effect than Sp aqueous extracts. Their combination, equivalent to 1/4 and 1/2 of MIC values of Gt and Sp extracts respectively, showed synergistic anti-plaque properties with fractional inhibitory concentration (FIC) equal to 0.75. This combination was found to significantly reduce CSH (p<0.05) and lower the adherence ability (p<0.003) towards experimental pellicles. CONCLUSION: Combination between Gt and Sp aqueous extracts exhibited synergistic anti-plaque activity, and could be used as a useful active agent to produce oral health care products.
[Mh] Termos MeSH primário: Actinomyces viscosus/efeitos dos fármacos
Placa Dentária/microbiologia
Extratos Vegetais/farmacologia
Salvadoraceae/química
Streptococcus mitis/efeitos dos fármacos
Streptococcus sanguis/efeitos dos fármacos
Chá/química
[Mh] Termos MeSH secundário: Actinomyces viscosus/fisiologia
Antibacterianos/farmacologia
Aderência Bacteriana/efeitos dos fármacos
Biofilmes/efeitos dos fármacos
Película Dentária/microbiologia
Placa Dentária/tratamento farmacológico
Sinergismo Farmacológico
Testes de Sensibilidade Microbiana
Saliva/química
Streptococcus mitis/fisiologia
Streptococcus sanguis/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Tea)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170813
[Lr] Data última revisão:
170813
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160626
[St] Status:MEDLINE


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[PMID]:27177110
[Au] Autor:El-Latif Hesham A; Alrumman SA
[Ad] Endereço:Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
[Ti] Título:Antibacterial activity of Miswak Salvadora persica extracts against isolated and genetically identified oral cavity pathogens.
[So] Source:Technol Health Care;24 Suppl 2:S841-8, 2016 Apr 29.
[Is] ISSN:1878-7401
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite medical progress worldwide, dental caries are still widespread. Miswak is derived from the plant Arak (Salvadora persica). It is used by Muslim peoples as a natural product for the cleansing of teeth, to ensure oral and dental hygiene. OBJECTIVE: This study was conducted to evaluate the antimicrobial effects of ethanol, methanol, and ethanol/methanol extracts of Miswak against three bacterial pathogens of the oral cavity. METHODS: The pathogens were isolated from the oral cavity of volunteers/patients and were identified on the basis of 16S rRNA gene amplification data. Sequence comparisons were made with 16S rRNA gene sequences available in the GenBank database. RESULTS: The results of sequence alignment and phylogenetic analysis identified the three pathogens as being Staphylococcus aureus strain KKU-020, Enterococcus faecalis strain KKU-021 and Klebsiella pneumoniae strain KKU-022. All Miswak extracts showed powerful antimicrobial activity against the three pathogens. The maximum zone of inhibition (40.67 ± 0.88 mm) was observed against E. faecalis KKU-021 with ethanolic extracts whilst methanolic extracts showed the minimum zone of inhibition (10.33 ± 0.88 mm) against K. pneumonia KKU-022. CONCLUSION: Based upon the significant effects of the Miswak extracts, against the oral cavity pathogens in our study, we recommend that Miswak could be used as a dental hygiene method to prevent tooth caries.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Antibacterianos/farmacologia
Enterococcus faecalis/efeitos dos fármacos
Klebsiella/efeitos dos fármacos
Boca/microbiologia
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Salvadoraceae
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Bases de Dados Genéticas
Cárie Dentária/prevenção & controle
Placa Dentária/prevenção & controle
Genes de RNAr
Seres Humanos
Higiene Bucal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.3233/THC-161214



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