Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.884.833 [Categoria DeCS] Referências encontradas : 92 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28749977 [Au] Autor: Wu C; Wang X [Ad] Endereço: Research Institute of Forest Resource Information Techniques, Chinese Academy of Forestry, Beijing, China. [Ti] Título: Preliminary research on the identification system for anthracnose and powdery mildew of sandalwood leaf based on image processing. [So] Source: PLoS One;12(7):e0181537, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This paper presents a survey on a system that uses digital image processing techniques to identify anthracnose and powdery mildew diseases of sandalwood from digital images. Our main objective is researching the most suitable identification technology for the anthracnose and powdery mildew diseases of the sandalwood leaf, which provides algorithmic support for the real-time machine judgment of the health status and disease level of sandalwood. We conducted real-time monitoring of Hainan sandalwood leaves with varying severity levels of anthracnose and powdery mildew beginning in March 2014. We used image segmentation, feature extraction and digital image classification and recognition technology to carry out a comparative experimental study for the image analysis of powdery mildew, anthracnose disease and healthy leaves in the field. Performing the actual test for a large number of diseased leaves pointed to three conclusions: (1) Distinguishing effects of BP (Back Propagation) neural network method, in all kinds of classical methods, for sandalwood leaf anthracnose and powdery mildew disease are relatively good; the size of the lesion areas were closest to the actual. (2) The differences between two diseases can be shown well by the shape feature, color feature and texture feature of the disease image. (3) Identifying and diagnosing the diseased leaves have ideal results by SVM, which is based on radial basis kernel function. The identification rate of the anthracnose and healthy leaves was 92% respectively, and that of powdery mildew was 84%. Disease identification technology lays the foundation for remote monitoring disease diagnosis, preparing for remote transmission of the disease images, which is a very good guide and reference for further research of the disease identification and diagnosis system in sandalwood and other species of trees. [Mh] Termos MeSH primário: Processamento de Imagem Assistida por Computador Doenças das Plantas/microbiologia Folhas de Planta/microbiologia Santalum/microbiologia [Mh] Termos MeSH secundário: Máquina de Vetores de Suporte [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170929 [Lr] Data última revisão: 170929 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0181537

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[PMID]: 28343686 [Au] Autor: Cagliero C; Bicchi C; Cordero C; Liberto E; Rubiolo P; Sgorbini B [Ad] Endereço: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, I-10125, Torino, Italy. [Ti] Título: Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids. [So] Source: J Chromatogr A;1495:64-75, 2017 Apr 28. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: In the fields of essential oils and fragrances, samples often consist of mixtures of compounds with similar structural and physical characteristics (e.g. mono- and sesquiterpenoids), whose correct identification closely depends on the synergic combination of chromatographic and mass spectral data. This sample complexity means that new GC stationary phases with different selectivities are continually being investigated. Ionic liquids (ILs) are of great interest as GC stationary phases in this field because of their selectivity (significantly different than that of currently phases) and their high temperature stability. A first generation of IL GC columns was found to be competitive when applied to these field, in terms of selectivity and efficiency, compared to conventional columns (polydimethylsiloxane, (e.g. OV-1), methyl-polysiloxane 5%-phenyl (e.g. SE-52), 7%-cyanopropyl, 7%-phenyl polysiloxane (e.g. OV-1701), and polyethylen glycol (e.g. PEG-20M). However, these columns showed significant activity towards polar or active analytes, which primarily affected their quantitative performance. A new generation of highly-inactive columns coated with three of the most widely-used ionic liquid GC stationary phases has recently been introduced; these phases are SLB-IL60i (1,12-di(tripropylphosphonium) dodecane bis(trifluoromethylsulfonyl) imide [NTf ], SLB-IL76i (tri-(tripropylphosphonium-hexanamido)-triethylamine [NTf ]), and SLB-IL111i (1,5-di (2,3-dimethyllimidazolium) pentane [NTf ]). This study carefully tested the new inert IL columns, in view of their routine application in the fragrance and essential oil fields. They were found to have unusually high selectivity, comparable to that of first-generation IL columns, while their inertness and efficiency were competitive with those of currently-used conventional columns. The IL column performance of first and second generations was compared, through the quali-quantitative analysis of components in a group of different complexity samples; these included the Grob test, a standard mixture of "suspected" skin allergens, and the essential oils of chamomile and sandalwood. [Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas Líquidos Iônicos/química Óleos Voláteis/análise [Mh] Termos MeSH secundário: Alérgenos/análise Farneseno Álcool/análise Óleos Voláteis/química Extratos Vegetais/química Santalum/química Santalum/metabolismo Sesquiterpenos/análise Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Allergens); 0 (Ionic Liquids); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 1DGG9VW8SA (santalol); 4602-84-0 (Farnesol) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170502 [Lr] Data última revisão: 170502 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170328 [St] Status: MEDLINE

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[PMID]: 27480682 [Au] Autor: Celedon JM; Bohlmann J [Ad] Endereço: Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada. [Ti] Título: Genomics-Based Discovery of Plant Genes for Synthetic Biology of Terpenoid Fragrances: A Case Study in Sandalwood oil Biosynthesis. [So] Source: Methods Enzymol;576:47-67, 2016. [Is] ISSN: 1557-7988 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Terpenoid fragrances are powerful mediators of ecological interactions in nature and have a long history of traditional and modern industrial applications. Plants produce a great diversity of fragrant terpenoid metabolites, which make them a superb source of biosynthetic genes and enzymes. Advances in fragrance gene discovery have enabled new approaches in synthetic biology of high-value speciality molecules toward applications in the fragrance and flavor, food and beverage, cosmetics, and other industries. Rapid developments in transcriptome and genome sequencing of nonmodel plant species have accelerated the discovery of fragrance biosynthetic pathways. In parallel, advances in metabolic engineering of microbial and plant systems have established platforms for synthetic biology applications of some of the thousands of plant genes that underlie fragrance diversity. While many fragrance molecules (eg, simple monoterpenes) are abundant in readily renewable plant materials, some highly valuable fragrant terpenoids (eg, santalols, ambroxides) are rare in nature and interesting targets for synthetic biology. As a representative example for genomics/transcriptomics enabled gene and enzyme discovery, we describe a strategy used successfully for elucidation of a complete fragrance biosynthetic pathway in sandalwood (Santalum album) and its reconstruction in yeast (Saccharomyces cerevisiae). We address questions related to the discovery of specific genes within large gene families and recovery of rare gene transcripts that are selectively expressed in recalcitrant tissues. To substantiate the validity of the approaches, we describe the combination of methods used in the gene and enzyme discovery of a cytochrome P450 in the fragrant heartwood of tropical sandalwood, responsible for the fragrance defining, final step in the biosynthesis of (Z)-santalols. [Mh] Termos MeSH primário: Genes de Plantas Genômica/métodos Engenharia Metabólica/métodos Óleos Vegetais/metabolismo Santalum/enzimologia Santalum/genética Sesquiterpenos/metabolismo [Mh] Termos MeSH secundário: Vias Biossintéticas Sistema Enzimático do Citocromo P-450/genética Sistema Enzimático do Citocromo P-450/metabolismo Metaboloma Proteínas de Plantas/genética Proteínas de Plantas/metabolismo Saccharomyces cerevisiae/enzimologia Saccharomyces cerevisiae/genética Saccharomyces cerevisiae/metabolismo Santalum/metabolismo Biologia Sintética/métodos Transcriptoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Oils); 0 (Plant Proteins); 0 (Sesquiterpenes); 1DGG9VW8SA (santalol); 9035-51-2 (Cytochrome P-450 Enzyme System); X7X01WMQ5F (sandalwood oil) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160803 [St] Status: MEDLINE

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[PMID]: 27416804 [Au] Autor: Biswas R; Mukherjee PK; Kar A; Bahadur S; Harwansh RK; Biswas S; Al-Dhabi NA; Duraipandiyan V [Ad] Endereço: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India. Electronic address: rajarshi_mpharm@rediff.com. [Ti] Título: Evaluation of Ubtan - A traditional indian skin care formulation. [So] Source: J Ethnopharmacol;192:283-291, 2016 Nov 04. [Is] ISSN: 1872-7573 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: 'Ubtan' is a traditional herbal formulation in the Indian system of medicine being used in India and its subcontinent for a long time. Several commercial skin care formulations are marketed throughout this region as the name of Ubtan. Therefore, it is worthwhile to evaluate Ubtan in respect of its efficacy as skin care formulation. AIM OF THE STUDY: The present study was designed for the preparation of Ubtan and standardization through the chromatographic techniques by using suitable phyto-markers. Further, its antioxidant, sun protection factor (SPF) and anti-tyrosinase potential have been explored. MATERIALS AND METHODS: Four in-house formulations (UF-1, UF-2, UF-3 and UF-4) were prepared by mixing a varied quantity of each powdered plants, i.e. turmeric (Curcuma longa L.), Chickpea (Cicer arietinum L.) and sandalwood (Santalum album L.). Optimization of the formulations was made by evaluating its biological activity through in vitro assay. Evaluation of physicochemical properties of the optimized formulation (UF-1) has been carried out by analysis of pH, flow properties and stability. Moreover, RP-HPLC (reverse phase - high performance liquid chromatography) and HPTLC (high performance thin layer chromatography) standardization of UF-1 was performed for its quantitative and qualitative analysis. RESULTS: Ubtan formulations (UF-1to UF-4) showed free radical scavenging and ferric reducing potential. It may be due to its high phenolic and flavonoid content. Statistically, significant Pearson's correlation (r) was confirmed the positive correlation between phenolic content and SPF of the formulations. The tyrosinase inhibition study indicated that the formulations showed both diphenolase and monophenolase inhibitory activity. Among four formulations, UF-1 showed notable biological activity (p<0.05). The content of curcumin and ascorbic acid was found to be 1.6% and 2.1% w/w respectively in UF-1 through RP-HPLC estimation. Physiochemical properties of the UF-1 exhibited good flow rate and aqueous solubility. From the stability studies, it can be anticipated that the UF-1 was stable at 40°C for longer periods. Microbial load count and heavy metal content (lead-Pb, arsenic-As, mercury-Hg and cadmium-Cd) of the formulation was also within the permissible limit of a pharmacopeial standard. CONCLUSION: This scientific exploration helps to set the quality and safety standard of traditional cosmetic formulation, Ubtan and its further use as an herbal skin care product. [Mh] Termos MeSH primário: Antioxidantes/farmacologia Curcumina/análogos & derivados Fármacos Dermatológicos/farmacologia Inibidores Enzimáticos/farmacologia Monofenol Mono-Oxigenase/antagonistas & inibidores Preparações de Plantas/farmacologia Higiene da Pele/métodos Protetores Solares/farmacologia [Mh] Termos MeSH secundário: Antioxidantes/química Antioxidantes/normas Ácido Ascórbico/farmacologia Carga Bacteriana Compostos de Bifenilo/química Cromatografia Líquida de Alta Pressão Cromatografia de Fase Reversa Cromatografia em Camada Delgada Cicer/química Segurança de Produtos ao Consumidor Curcuma/química Curcumina/química Curcumina/farmacologia Fármacos Dermatológicos/química Fármacos Dermatológicos/normas Relação Dose-Resposta a Droga Composição de Medicamentos Contaminação de Medicamentos Estabilidade de Medicamentos Inibidores Enzimáticos/química Inibidores Enzimáticos/normas Ferricianetos/química Concentração de Íons de Hidrogênio Índia Medicina Tradicional Metais Pesados/análise Oxirredução Fitoterapia Picratos/química Preparações de Plantas/química Preparações de Plantas/normas Plantas Medicinais Pós Controle de Qualidade Reologia Medição de Risco Santalum/química Higiene da Pele/normas Solubilidade Espectrofotometria Atômica Espectrofotometria Ultravioleta Protetores Solares/química Protetores Solares/normas [Pt] Tipo de publicação: COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Dermatologic Agents); 0 (Enzyme Inhibitors); 0 (Ferricyanides); 0 (Metals, Heavy); 0 (Picrates); 0 (Plant Preparations); 0 (Powders); 0 (Sunscreening Agents); 0 (ubtan compound); 13408-62-3 (hexacyanoferrate III); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.14.18.1 (Monophenol Monooxygenase); IT942ZTH98 (Curcumin); PQ6CK8PD0R (Ascorbic Acid) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170912 [Lr] Data última revisão: 170912 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160716 [St] Status: MEDLINE

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[PMID]: 26991058 [Au] Autor: Celedon JM; Chiang A; Yuen MM; Diaz-Chavez ML; Madilao LL; Finnegan PM; Barbour EL; Bohlmann J [Ad] Endereço: Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. [Ti] Título: Heartwood-specific transcriptome and metabolite signatures of tropical sandalwood (Santalum album) reveal the final step of (Z)-santalol fragrance biosynthesis. [So] Source: Plant J;86(4):289-99, 2016 05. [Is] ISSN: 1365-313X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Tropical sandalwood (Santalum album) produces one of the world's most highly prized fragrances, which is extracted from mature heartwood. However, in some places such as southern India, natural populations of this slow-growing tree are threatened by over-exploitation. Sandalwood oil contains four major and fragrance-defining sesquiterpenols: (Z)-α-santalol, (Z)-ß-santalol, (Z)-epi-ß-santalol and (Z)-α-exo-bergamotol. The first committed step in their biosynthesis is catalyzed by a multi-product santalene/bergamotene synthase. Sandalwood cytochromes P450 of the CYP76F sub-family were recently shown to hydroxylate santalenes and bergamotene; however, these enzymes produced mostly (E)-santalols and (E)-α-exo-bergamotol. We hypothesized that different santalene/bergamotene hydroxylases evolved in S. album to stereo-selectively produce (E)- or (Z)-sesquiterpenols, and that genes encoding (Z)-specific P450s contribute to sandalwood oil formation if co-expressed in the heartwood with upstream genes of sesquiterpene biosynthesis. This hypothesis was validated by the discovery of a heartwood-specific transcriptome signature for sesquiterpenoid biosynthesis, including highly expressed SaCYP736A167 transcripts. We characterized SaCYP736A167 as a multi-substrate P450, which stereo-selectively produces (Z)-α-santalol, (Z)-ß-santalol, (Z)-epi-ß-santalol and (Z)-α-exo-bergamotol, matching authentic sandalwood oil. This work completes the discovery of the biosynthetic enzymes of key components of sandalwood fragrance, and highlights the evolutionary diversification of stereo-selective P450s in sesquiterpenoid biosynthesis. Bioengineering of microbial systems using SaCYP736A167, combined with santalene/bergamotene synthase, has potential for development of alternative industrial production systems for sandalwood oil fragrances. [Mh] Termos MeSH primário: Vias Biossintéticas Óleos Vegetais/metabolismo Santalum/metabolismo Sesquiterpenos/metabolismo Transcriptoma [Mh] Termos MeSH secundário: Sistema Enzimático do Citocromo P-450/metabolismo Genes de Plantas Filogenia Óleos Vegetais/química Santalum/enzimologia Santalum/genética Sesquiterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Plant Oils); 0 (Sesquiterpenes); 1DGG9VW8SA (santalol); 9035-51-2 (Cytochrome P-450 Enzyme System); X7X01WMQ5F (sandalwood oil) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160319 [St] Status: MEDLINE [do] DOI: 10.1111/tpj.13162

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[PMID]: 26806578 [Au] Autor: Sabroe RA; Holden CR; Gawkrodger DJ [Ad] Endereço: Department of Dermatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK. [Ti] Título: Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series. [So] Source: Contact Dermatitis;74(4):236-41, 2016 Apr. [Is] ISSN: 1600-0536 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Essential oils are fragrance substances that are labelled on cosmetic products by their INCI names, potentially confusing consumers. OBJECTIVES: To establish whether contact allergy to essential oils might be missed if not specifically tested for. METHODS: We tested 471 patients with 14 essential oils and 2104 patients with Melaleuca alternifolia oil between January 2008 and June 2014. All patients were tested with fragrance mix I, fragrance mix II, hydroxyisohexyl 3-cyclohexene carboxaldehyde, and Myroxylon pereirae. Three hundred and twenty-six patients were tested with hydroperoxides of limonene and linalool. RESULTS: Thirty-four patients had a +/++/+++ reaction to at least one essential oil. Eleven had no reaction to any of the six marker fragrance substances. Thus, 4 of 11 positive reactions to M. alternifolia oil, 2 of 7 reactions to Cymbopogon flexuosus oil, 1 of 5 reactions to Cananga odorata oil, 3 of 4 reactions to Santalum album oil and 2 of 3 reactions to Mentha piperita oil would have been missed without individual testing. CONCLUSION: A small number of patients who are allergic to essential oils could be missed if these are not specifically tested. Labelling by INCI names means that exposure may not be obvious. Careful inspection of so-called 'natural' products and targeted testing is recommended. [Mh] Termos MeSH primário: Alérgenos/efeitos adversos Dermatite Alérgica de Contato/etiologia Óleos Voláteis/efeitos adversos Perfumes/efeitos adversos [Mh] Termos MeSH secundário: Aldeídos/efeitos adversos Cananga/efeitos adversos Cosméticos/efeitos adversos Cosméticos/química Cicloexenos/efeitos adversos Cymbopogon/efeitos adversos Seres Humanos Monoterpenos/efeitos adversos Myroxylon/efeitos adversos Testes do Emplastro Óleos Vegetais/efeitos adversos Rotulagem de Produtos Estudos Retrospectivos Santalum/efeitos adversos Óleo de Melaleuca/efeitos adversos Terpenos/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aldehydes); 0 (Allergens); 0 (Cosmetics); 0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Perfume); 0 (Plant Oils); 0 (Terpenes); 68647-73-4 (Tea Tree Oil); 9MC3I34447 (limonene); AV092KU4JH (peppermint oil); D81QY6I88E (linalool); QUE43B9Z2Q (hydroxyisohexyl 3-cyclohexene carboxaldehyde) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160126 [St] Status: MEDLINE [do] DOI: 10.1111/cod.12528

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[PMID]: 26745967 [Au] Autor: Teixeira da Silva JA; Kher MM; Soner D; Page T; Zhang X; Nataraj M; Ma G [Ad] Endereço: , P. O. Box 7, Miki-cho Post Office, 3011-2, Ikenobe, Kagawa-ken, 761-0799, Japan. jaimetex@yahoo.com. [Ti] Título: Sandalwood: basic biology, tissue culture, and genetic transformation. [So] Source: Planta;243(4):847-87, 2016 Apr. [Is] ISSN: 1432-2048 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: MAIN CONCLUSION: Sustainable resource preservation of Santalum species that yield commercially important forest products is needed. This review provides an understanding of their basic biology, propagation, hemi-parasitic nature, reproductive biology, and biotechnology. Many species of the genus Santalum (Santalaceae) have been exploited unremittingly for centuries, resulting in the extinction of one and the threatened status of three other species. This reduction in biodiversity of sandalwood has resulted from the commercial exploitation of its oil-rich fragrant heartwood. In a bid to conserve the remaining germplasm, biotechnology provides a feasible, and effective, means of propagating members of this genus. This review provides a detailed understanding of the biological mechanisms underlying the success or failure of traditional propagation, including a synopsis of the process of hemi-parasitism in S. album, and of the suitability of host plants to sustain the growth of seedlings and plants under forestry production. For the mass production of economically important metabolites, and to improve uniformity of essential oils, the use of clonal material of similar genetic background for cultivation is important. This review summarizes traditional methods of sandalwood production with complementary and more advanced in vitro technologies to provide a basis for researchers, conservationists and industry to implement sustainable programs of research and development for this revered genus. [Mh] Termos MeSH primário: Técnicas de Embriogênese Somática de Plantas/métodos Santalum/fisiologia Técnicas de Cultura de Tecidos/métodos [Mh] Termos MeSH secundário: Biotecnologia/métodos Agricultura Florestal/métodos Especificidade de Hospedeiro Santalum/genética Plântulas/crescimento & desenvolvimento Autoincompatibilidade em Angiospermas [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 171005 [Lr] Data última revisão: 171005 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160110 [St] Status: MEDLINE [do] DOI: 10.1007/s00425-015-2452-8

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[PMID]: 26410184 [Au] Autor: Pantò S; Sciarrone D; Maimone M; Ragonese C; Giofrè S; Donato P; Farnetti S; Mondello L [Ad] Endereço: "Scienze del Farmaco e Prodotti per la Salute" Department, University of Messina, viale Annunziata, 98168 Messina, Italy. [Ti] Título: Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography-two-dimensional gas chromatography for the collection of volatile constituents. [So] Source: J Chromatogr A;1417:96-103, 2015 Oct 23. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The present research deals with the multi-collection of the most important sesquiterpene alcohols belonging to sandalwood essential oil, as reported by the international regulations: (Z)-α-santalol, (Z)-α-trans bergamotol, (Z)-ß-santalol, epi-(Z)-ß-santalol, α-bisabolol, (Z)-lanceol, and (Z)-nuciferol. A versatile multidimensional preparative system, based on the hyphenation of liquid and gas chromatography techniques, was operated in the LC-GC-GC-prep or GC-GC-GC-prep configuration, depending on the concentration to be collected from the sample, without any hardware or software modification. The system was equipped with a silica LC column in combination with polyethylene glycol-poly(5% diphenyl/95% dimethylsiloxane)-medium polarity ionic liquid or ß-cyclodextrin based GC stationary phases. The GC-GC-GC-prep configuration was exploited for the collection of four components, by using a conventional split/splitless injector, while the LC-GC-GC-prep approach was applied for three low abundant components (<5%), in order to increase the quantity collected within a single run, by the LC injection of a high sample amount. All target compounds, whose determination is hampered by the unavailability of commercial standards, were collected at milligram levels and with a high degree of purity (>87%). [Mh] Termos MeSH primário: Cromatografia Gasosa/métodos Cromatografia Líquida/métodos Óleos Voláteis/análise [Mh] Termos MeSH secundário: Dimetilpolisiloxanos Óleos Vegetais/análise Polietilenoglicóis Santalum/química Sesquiterpenos/análise Dióxido de Silício beta-Ciclodextrinas/análise [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Dimethylpolysiloxanes); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (beta-Cyclodextrins); 1DGG9VW8SA (santalol); 24WE03BX2T (bisabolol); 30IQX730WE (Polyethylene Glycols); 7631-86-9 (Silicon Dioxide); JV039JZZ3A (betadex); X7X01WMQ5F (sandalwood oil) [Em] Mês de entrada: 1605 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150928 [St] Status: MEDLINE

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[PMID]: 26369011 [Au] Autor: Kitture R; Chordiya K; Gaware S; Ghosh S; More PA; Kulkarni P; Chopade BA; Kale SN [Ti] Título: ZnO Nanoparticles-Red Sandalwood Conjugate: A Promising Anti-Diabetic Agent. [So] Source: J Nanosci Nanotechnol;15(6):4046-51, 2015 Jun. [Is] ISSN: 1533-4880 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: With the advances in nanoscience and nanotechnology the interest of researchers has expanded to interdisciplinary domain like bio-medical applications. Among such domains, one of the most important areas explored meticulously is the development of promising solutions in diabetes therapeutics. The disease associated with metabolic disorder, is one of the major challenges, due to its ever-increasing number of patients. The adverse effects of the synthetic enzymes like α-amylase and α-glucosidase inhibitors have invited many scientists to develop promising contender with minimal side-effects. On the other hand, Zinc has strong role in insulin synthesis, storage and secretion and thus its deficiency can be related to diabetes. In this context we have explored natural extract of Red Sandalwood (RSW) as a potent anti-diabetic agent, in conjugation with ZnO nanoparticles. ZnO nanoparticles have been synthesized via soft chemistry routes and duly characterized for their phase formation with the help of X-ray diffraction technique and Field-Emission Scanning Electron Microscopy. These monodispersed nanoparticles, -20 nm in size, were further conjugated to RSW extract. The conjugation chemistry was studied via Fourier transform infrared spectroscopy, UV-visible spectroscopy. Extract loading percentage was found from thermo-gravimetric analysis. 65% of the RSW extract was found conjugated to the ZnO nanoparticles. The anti-diabetic activity was assessed with the help of like α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts. It was observed that the conjugated ZnO-RSW nanoparticles showed excellent activity against the crude murine pancreatic glucosidase as compared to the individual ZnO nanoparticles and the RSW extract. The ZnO-RSW conjugate showed 61.93% of inhibition while the bare ZnO nanoparticles and RSW showed 21.48% and 5.90% respectively. [Mh] Termos MeSH primário: Hipoglicemiantes/química Nanopartículas Metálicas/química Extratos Vegetais/química Santalum/química Óxido de Zinco/química [Mh] Termos MeSH secundário: Animais Glucosidases/antagonistas & inibidores Glucosidases/efeitos dos fármacos Glucosidases/metabolismo Hipoglicemiantes/farmacologia Masculino Camundongos Extratos Vegetais/farmacologia Suínos alfa-Amilases/antagonistas & inibidores alfa-Amilases/efeitos dos fármacos alfa-Amilases/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hypoglycemic Agents); 0 (Plant Extracts); EC 3.2.1.- (Glucosidases); EC 3.2.1.1 (alpha-Amylases); SOI2LOH54Z (Zinc Oxide) [Em] Mês de entrada: 1511 [Cu] Atualização por classe: 150915 [Lr] Data última revisão: 150915 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150916 [St] Status: MEDLINE

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[PMID]: 26026073 [Au] Autor: Santha S; Dwivedi C [Ad] Endereço: Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, U.S.A. [Ti] Título: Anticancer Effects of Sandalwood (Santalum album). [So] Source: Anticancer Res;35(6):3137-45, 2015 Jun. [Is] ISSN: 1791-7530 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: Effective management of tumorigenesis requires development of better anticancer agents with greater efficacy and fewer side-effects. Natural products are important sources for the development of chemotherapeutic agents and almost 60% of anticancer drugs are of natural origin. α-Santlol, a sesquiterpene isolated from Sandalwood, is known for a variety of therapeutic properties including anti-inflammatory, anti-oxidant, anti-viral and anti-bacterial activities. Cell line and animal studies reported chemopreventive effects of sandalwood oil and α-santalol without causing toxic side-effects. Our laboratory identified its anticancer effects in chemically-induced skin carcinogenesis in CD-1 and SENCAR mice, ultraviolet-B-induced skin carcinogenesis in SKH-1 mice and in vitro models of melanoma, non-melanoma, breast and prostate cancer. Its ability to induce cell-cycle arrest and apoptosis in cancer cells is its most reported anticancer mechanism of action. The present review discusses studies that support the anticancer effect and the mode of action of sandalwood oil and α-santalol in carcinogenesis. [Mh] Termos MeSH primário: Carcinogênese/efeitos dos fármacos Óleos Vegetais/uso terapêutico Santalum/química Neoplasias Cutâneas/tratamento farmacológico [Mh] Termos MeSH secundário: Animais Apoptose/efeitos dos fármacos Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Seres Humanos Camundongos Extratos Vegetais/química Extratos Vegetais/uso terapêutico Neoplasias Cutâneas/induzido quimicamente [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Plant Extracts); 0 (Plant Oils) [Em] Mês de entrada: 1508 [Cu] Atualização por classe: 150530 [Lr] Data última revisão: 150530 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150531 [St] Status: MEDLINE

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