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Pesquisa : B01.650.940.800.575.912.250.885.861 [Categoria DeCS]
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[PMID]:29221478
[Au] Autor:Shah M; Parveen Z; Khan MR
[Ad] Endereço:Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
[Ti] Título:Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi.
[So] Source:BMC Complement Altern Med;17(1):526, 2017 Dec 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Saponins are the main constituents of genus Sapindus and have the therapeutic potential for inflammatory disorders. In this study the antioxidant, anti-inflammatory, analgesic and antipyretic potential of the stem bark of soap nut (Sapindus mukorossi) methanol extract and its derived fractions has been investigated. METHODS: Powder of stem bark of the S. mukorossi was extracted with methanol (SMM) and fractionated in order of n-hexane (SMH), chloroform (SMC), ethyl acetate (SME), n-butanol (SMB) and the remaining as aqueous fraction (SMA). Quantitative estimation for the total phenolic and total flavonoid content was carried out in all the extract/fractions. Further, various in vitro antioxidant assays were also performed. Anti-inflammatory (Carrageenan induced paw edema), analgesic (hot plate latency test) and antipyretic (rectal temperature) were determined in Sprague-Dawley rat. RESULTS: Quantitative estimation of total phenolic contents in extract/fractions varied between 252.3 ± 2.41 mg of GAE/g - 594.16 ± 4.3 mg of GAE/g while the total flavonoids estimated were from 11.02 ± 1.3 mg of RUE/g to 96.9 ± 3.2 mg of RUE/g. Standard antioxidant assays such as scavenging of DPPH, hydroxyl radical, nitric oxide, phosphomolybdenum assay, reducing power, inhibition of ß-carotene bleaching, iron chelation activity and inhibition of heat induced protein denaturation indicated the antioxidant potential of the extract/fractions. Carrageenan induced paw edema of rat was effectively inhibited by SMA at 300 mg/kg administration to rat (84.19 ± 1.48%) after 3 h and analgesia (latency time) in hot plate test (55.78 ± 1.22%) after 120 min. SMA at 300 mg/kg distinctly decreased the rectal temperature in brewer's yeast (Saccharomyces cerevisiae) induced pyrexia in rat. CONCLUSION: The resulted obtained in this study suggested the therapeutic importance of stem bark of S. mukorossi in inflammatory related disorders.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Antipiréticos/farmacologia
Extratos Vegetais/farmacologia
Sapindus
[Mh] Termos MeSH secundário: Analgésicos/química
Animais
Anti-Inflamatórios/química
Antioxidantes/química
Antipiréticos/química
Comportamento Animal/efeitos dos fármacos
Compostos de Bifenilo/metabolismo
Temperatura Corporal/efeitos dos fármacos
Edema
Feminino
Flavonoides/química
Flavonoides/farmacologia
Masculino
Picratos/metabolismo
Casca de Planta
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Antipyretics); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2042-3


  2 / 81 MEDLINE  
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[PMID]:27412340
[Au] Autor:Mukhopadhyay S; Mukherjee S; Hashim MA; Sen Gupta B
[Ad] Endereço:Department of Chemical Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Remediation of Arsenic Contaminated Soil Using Phosphate and Colloidal Gas Aphron Suspensions Produced from Sapindus mukorossi.
[So] Source:Bull Environ Contam Toxicol;98(3):366-372, 2017 Mar.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phosphate and colloidal gas aphrons (CGAs) generated from saponin extracted from Sapindus mukorossi fruit, were evaluated for washing low levels of arsenic from an iron rich soil. Phosphate is one of the most commonly dispersed chemicals that increases arsenic mobility in soil due to their structural similarities, making it an important factor in arsenic removal process. Column washing experiments were performed with CGAs in down flow and up flow modes on soil of pH 5 and 6. Soapnut CGAs, when paired with phosphate removed up to 95 % arsenic while soapnut CGAs alone could only remove up to 70 % arsenic. The presence of phosphate improved efficiency of soapnut solution by up to 35 %. SEM image of washed soil revealed minor corrosion of soil surface while using phosphate with soapnut. Therefore, the addition of phosphates would have positive impact on soil washing using soapnut saponin.
[Mh] Termos MeSH primário: Arsênico/análise
Recuperação e Remediação Ambiental/métodos
Microbolhas
Fosfatos/química
Sapindus/química
Solo/química
Suspensões/química
[Mh] Termos MeSH secundário: Saponinas/química
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphates); 0 (Saponins); 0 (Soil); 0 (Soil Pollutants); 0 (Suspensions); N712M78A8G (Arsenic)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-016-1878-4


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[PMID]:27819730
[Au] Autor:Garcia A; Polonio JC; Polli AD; Santos CM; Rhoden SA; Quecine MC; Azevedo JL; Pamphile JA
[Ad] Endereço:Laboratório de Biotecnologia Microbiana, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brasil.
[Ti] Título:Rhizosphere bacteriome of the medicinal plant Sapindus saponaria L. revealed by pyrosequencing.
[So] Source:Genet Mol Res;15(4), 2016 Nov 03.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Sapindus saponaria L. of Sapindaceae family is popularly known as soldier soap and is found in Central and South America. A study of such medicinal plants might reveal a more complex diversity of microorganisms as compared to non-medicinal plants, considering their metabolic potential and the chemical communication between their natural microbiota. Rhizosphere is a highly diverse microbial habitat with respect to both the diversity of species and the size of the community. Rhizosphere bacteriome associated with medicinal plant S. saponaria is still poorly known. The objective of this study was to assess the rhizosphere microbiome of the medicinal plant S. saponaria using pyrosequencing, a culture-independent approach that is increasingly being used to estimate the number of bacterial species present in different environments. In their rhizosphere microbiome, 26 phyla were identified from 5089 sequences of 16S rRNA gene, with a predominance of Actinobacteria (33.54%), Acidobacteria (22.62%), and Proteobacteria (24.72%). The rarefaction curve showed a linear increase, with 2660 operational taxonomic units at 3% distance sequence dissimilarity, indicating that the rhizosphere microbiome associated with S. saponaria was highly diverse with groups of bacteria important for soil management, which could be further exploited for agricultural and biotechnological purposes.
[Mh] Termos MeSH primário: Microbiota
Plantas Medicinais/microbiologia
Rizosfera
Sapindus/genética
Sapindus/microbiologia
Análise de Sequência de DNA/métodos
Temperatura Ambiente
[Mh] Termos MeSH secundário: Bactérias/classificação
Biodiversidade
Filogenia
Plantas Medicinais/genética
RNA Ribossômico 16S/genética
Microbiologia do Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE
[do] DOI:10.4238/gmr15049020


  4 / 81 MEDLINE  
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Svidzinski, Terezinha Inez Estivalet
PubMed Central Texto completo
Texto completo SciELO Brasil
[PMID]:27074319
[Au] Autor:Fiorini A; Rosado FR; Bettega EM; Melo KC; Kukolj C; Bonfim-Mendonça Pde S; Shinobu-Mesquita CS; Ghiraldi LD; Campanerut PA; Capoci IR; Godoy JS; Ferreira IC; Svidzinski TI
[Ad] Endereço:Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, PR, Brazil, drifiorini@gmail.com, eliane.martins.bettega@gmail.com, katiasibin@gmail.com, patbonfim.09@gmail.com, cristianeshinobu@gmail.com, ldghiraldi@gmail.com, paulacampanerut@gmail.com, isiscapoci@gmail.
[Ti] Título:Candida albicans PROTEIN PROFILE CHANGES IN RESPONSE TO THE BUTANOLIC EXTRACT OF Sapindus saponariaL.
[So] Source:Rev Inst Med Trop Sao Paulo;58:25, 2016.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Candida albicans is an opportunistic human pathogen that is capable of causing superficial and systemic infections in immunocompromised patients. Extracts of Sapindus saponaria have been used as antimicrobial agents against various organisms. In the present study, we used a combination of two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) to identify the changes in protein abundance of C. albicans after exposure to the minimal inhibitory concentration (MIC) and sub-minimal inhibitory concentration (sub-MIC) of the butanolic extract (BUTE) of S. saponaria and also to fluconazole. A total of six different proteins with greater than 1.5 fold induction or repression relative to the untreated control cells were identified among the three treatments. In general, proteins/enzymes involved with the glycolysis (GPM1, ENO1, FBA1), amino acid metabolism (ILV5, PDC11) and protein synthesis (ASC1) pathways were detected. In conclusion, our findings reveal antifungal-induced changes in protein abundance of C. albicans. By using the previously identified components of the BUTE of S. saponaria(e.g., saponins and sesquiterpene oligoglycosides), it will be possible to compare the behavior of compounds with unknown mechanisms of action, and this knowledge will help to focus the subsequent biochemical work aimed at defining the effects of these compounds.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Fluconazol/farmacologia
Proteínas Fúngicas/análise
Extratos Vegetais/farmacologia
Sapindus/química
[Mh] Termos MeSH secundário: Candida albicans/química
Eletroforese em Gel Bidimensional
Espectrometria de Massas
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fungal Proteins); 0 (Plant Extracts); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE


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[PMID]:26954087
[Au] Autor:Smulek W; Zdarta A; Luczak M; Krawczyk P; Jesionowski T; Kaczorek E
[Ad] Endereço:Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.
[Ti] Título:Sapindus saponins' impact on hydrocarbon biodegradation by bacteria strains after short- and long-term contact with pollutant.
[So] Source:Colloids Surf B Biointerfaces;142:207-13, 2016 Jun 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The introduction of high toxicity petroleum contaminants to the natural environment causes damage to ecosystems and the aesthetics of the surroundings. Therefore it is critical to enhance microbial community performance to manage the degradation process. This paper analyses the effect of natural surfactants from the tree Sapindus mukorossi on biodegradation of hydrocarbons. Analysis of cell surface hydrophobicity and zeta potential confirmed effective modifications of the cell surface parameters essential for the bioavailability of contaminants to microorganisms. Interestingly, favorable differences were observed only for microorganisms from non-contaminated soil. There was also recorded an increase in diesel oil biodegradation to 41% for Sphingomonas sp. and 56% for Pseudomonas alcaligenes on addition of 100mgL(-1) of Sapindus saponins. The addition of natural surfactants has no significant impact on bacterial strains isolated from long-term contaminated soil. This research demonstrates that the addition of Sapindus extract could be a useful tool to improve the effectiveness of microbial degradation of hydrocarbon pollutants by environmental strains in recently contaminated.
[Mh] Termos MeSH primário: Hidrocarbonetos/metabolismo
Pseudomonas alcaligenes/efeitos dos fármacos
Sapindus/química
Saponinas/farmacologia
Poluentes do Solo/metabolismo
Sphingomonas/efeitos dos fármacos
Tensoativos/farmacologia
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Técnicas Eletroquímicas
Poluição Ambiental
Gasolina
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Consórcios Microbianos/efeitos dos fármacos
Pseudomonas alcaligenes/crescimento & desenvolvimento
Pseudomonas alcaligenes/metabolismo
Saponinas/isolamento & purificação
Sphingomonas/crescimento & desenvolvimento
Sphingomonas/metabolismo
Propriedades de Superfície
Tensoativos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gasoline); 0 (Hydrocarbons); 0 (Saponins); 0 (Soil Pollutants); 0 (Surface-Active Agents)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE


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[PMID]:26158392
[Au] Autor:Zhang XM; Yang DP; Xie ZY; Li Q; Zhu LP; Zhao ZM
[Ad] Endereço:a School of Pharmaceutical Sciences , Sun Yat-sen University (Higher Education Mega Center) , 132 Waihuan Rd East, Panyu District, Guangzhou 510006 , China.
[Ti] Título:Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells.
[So] Source:Nat Prod Res;30(13):1459-63, 2016 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new glycosides (1, 2) and two saponins (3, 4) were isolated from the fruits of Sapindus mukorossi Gaertn. The two glycosides were designated as sapindoside G (1) and 4'',4'''''-O-diacetylmukurozioside IIa (2). All four compounds exhibited inhibitory effects against A549 human lung adenocarcinoma cells with inhibition rates up to 69.2-83.3% at a concentration of 100 µg/mL. Flow cytometric analysis revealed that compounds 1-4 could suppress A549 cell growth by promoting cell apoptosis, which was related to the activation of caspase-3.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Glicosídeos/isolamento & purificação
Neoplasias Pulmonares/tratamento farmacológico
Extratos Vegetais/farmacologia
Sapindus/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Ativação Enzimática
Frutas/química
Glicosídeos/farmacologia
Seres Humanos
Neoplasias Pulmonares/enzimologia
Neoplasias Pulmonares/patologia
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts); 0 (Saponins); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1054283


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[PMID]:26489418
[Au] Autor:Gandreddi VD; Kappala VR; Zaveri K; Patnala K
[Ad] Endereço:Assistant professor, Department of Biochemistry/Bioinformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam, 530045, Andhra Pradesh, India. gvd.divya@gmail.com.
[Ti] Título:Evaluating the role of a trypsin inhibitor from soap nut (Sapindus trifoliatus L. Var. Emarginatus) seeds against larval gut proteases, its purification and characterization.
[So] Source:BMC Biochem;16:23, 2015 Oct 22.
[Is] ISSN:1471-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection against proteolytic enzymes of pathogens. METHODS: An array of chromatographic techniques were employed for purification, homogeneity was assessed by electrophoresis. Specificity, Ki value, nature of inhibition, complex formation was carried out by standard protocols. Action of SNTI on insect gut proteases was computationally evaluated by modeling the proteins by threading and docking studies by piper using Schrodinger tools. RESULTS: We have isolated and purified Soap Nut Trypsin Inhibitor (SNTI) by acetone fractionation, ammonium sulphate precipitation, ion exchange and gel permeation chromatography. The purified inhibitor was homogeneous by both gel filtration and polyacrylamide gel electrophoresis (PAGE). SNTI exhibited a molecular weight of 29 kDa on SDS-PAGE, gel filtration and was negative to Periodic Acid Schiff's stain. SNTI inhibited trypsin and pronase of serine class. SNTI demonstrated non-competitive inhibition with a Ki value of 0.75 ± 0.05×10-10 M. The monoheaded inhibitor formed a stable complex in 1:1 molar ratio. Action of SNTI was computationally evaluated on larval gut proteases from Helicoverpa armigera and Spodoptera frugiperda. SNTI and larval gut proteases were modeled and docked using Schrodinger software. Docking studies revealed strong hydrogen bond interactions between Lys10 and Pro71, Lys299 and Met80 and Van Der Waals interactions between Leu11 and Cys76amino acid residues of SNTI and protease from H. Armigera. Strong hydrogen bonds were observed between SNTI and protease of S. frugiperda at positions Thr79 and Arg80, Asp90 and Gly73, Asp2 and Gly160 respectively. CONCLUSION: We conclude that SNTI potentially inhibits larval gut proteases of insects and the kinetics exhibited by the protease inhibitor further substantiates its efficacy against serine proteases.
[Mh] Termos MeSH primário: Intestinos/enzimologia
Peptídeo Hidrolases/metabolismo
Sapindus/química
Sementes/química
Inibidores da Tripsina/isolamento & purificação
Inibidores da Tripsina/farmacologia
[Mh] Termos MeSH secundário: Animais
Larva/enzimologia
Modelos Moleculares
Peso Molecular
Conformação Proteica
Spodoptera/enzimologia
Inibidores da Tripsina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Trypsin Inhibitors); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151023
[St] Status:MEDLINE
[do] DOI:10.1186/s12858-015-0052-7


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[PMID]:26328472
[Au] Autor:Isenberg SL; Carter MD; Graham LA; Mathews TP; Johnson D; Thomas JD; Pirkle JL; Johnson RC
[Ad] Endereço:Oak Ridge Institute for Science and Education Fellow, ‡Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia 30341, United States.
[Ti] Título:Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine.
[So] Source:Chem Res Toxicol;28(9):1753-9, 2015 Sep 21.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ingestion of soapberry fruit toxins hypoglycin A and methylenecyclopropylglycine has been linked to public health challenges worldwide. In 1976, over 100 years after Jamaican vomiting sickness (JVS) was first reported, the cause of JVS was linked to the ingestion of the toxin hypoglycin A produced by ackee fruit. A structural analogue of hypoglycin A, methylenecyclopropylglycine (MCPG), was implicated as the cause of an acute encephalitis syndrome (AES). Much of the evidence linking hypoglycin A and MCPG to these diseases has been largely circumstantial due to the lack of an analytical method for specific metabolites. This study presents an analytical approach to identify and quantify specific urine metabolites for exposure to hypoglycin A and MCPG. The metabolites are excreted in urine as glycine adducts methylenecyclopropylacetyl-glycine (MCPA-Gly) and methylenecyclopropylformyl-glycine (MCPF-Gly). These metabolites were processed by isotope dilution, separated by reverse-phase liquid chromatography, and monitored by electrospray ionization tandem mass spectrometry. The analytical response ratio was linearly proportional to the concentration of MCPF-Gly and MCPA-Gly in urine from 0.10 to 20 µg/mL with a correlation coefficient of r > 0.99. The assay demonstrated accuracy ≥80% and precision ≤20% RSD across the calibration range. This method has been applied to assess exposure to hypoglycin A and MCPG as part of a larger public health initiative and was used to provide the first reported identification of MCPF-Gly and MCPA-Gly in human urine.
[Mh] Termos MeSH primário: Ciclopropanos/toxicidade
Exposição Ambiental
Glicina/análogos & derivados
Hipoglicinas/toxicidade
Sapindus/química
[Mh] Termos MeSH secundário: Animais
Glicina/toxicidade
Seres Humanos
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Hypoglycins); 156-56-9 (hypoglycin); 2517-07-9 (methylenecyclopropylglycine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150903
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.5b00205


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[PMID]:26208689
[Au] Autor:Singh R; Rai MK; Kumari N
[Ad] Endereço:Department of Botany, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India, reetikasingh.bhu@gmail.com.
[Ti] Título:Somatic Embryogenesis and Plant Regeneration in Sapindus mukorossi Gaertn. from Leaf-Derived Callus Induced with 6-Benzylaminopurine.
[So] Source:Appl Biochem Biotechnol;177(2):498-510, 2015 Sep.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A somatic embryogenesis system was developed for Sapindus mukorossi Gaertn. from leaf explants obtained from fresh flushes of a mature tree. Callus was induced from the midrib region of leaf explants on Murashige and Skoog (MS) medium containing different concentrations of 2,4-dichlorophenoxyacetic acid or 6-benzylaminopurine. Callus induction and somatic embryogenesis was significantly influenced by the size, physiological age, and orientation of leaf explants on the culture medium and plant growth regulators. Adaxial-side-up orientation of leaf explants significantly promoted embryogenesis in comparison with abaxial-side-up orientation. Maximum number of somatic embryos was induced on MS medium supplemented with 8.88 µM 6-benzylaminopurine. Scanning electron microscopy of embryogenic callus revealed somatic embryo origin and the development of globular-, heart-, and cotyledonary-stage somatic embryos. The frequency of maturation as well as germination of somatic embryos was higher on MS medium containing 8.88 µM 6-benzylaminopurine than on medium without 6-benzylaminopurine. Plantlets which developed from somatic embryos were acclimatized successfully with 90 % survival.
[Mh] Termos MeSH primário: Cinetina/farmacologia
Folhas de Planta/fisiologia
Técnicas de Embriogênese Somática de Plantas/métodos
Regeneração/fisiologia
Sapindus/embriologia
Sapindus/fisiologia
[Mh] Termos MeSH secundário: Ácido Abscísico/farmacologia
Aclimatação/efeitos dos fármacos
Compostos de Benzil
Germinação/efeitos dos fármacos
Folhas de Planta/efeitos dos fármacos
Purinas
Regeneração/efeitos dos fármacos
Sapindus/efeitos dos fármacos
Sementes/efeitos dos fármacos
Sementes/ultraestrutura
Sacarose/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Purines); 57-50-1 (Sucrose); 72S9A8J5GW (Abscisic Acid); KXG6A989PS (benzylaminopurine); P39Y9652YJ (Kinetin)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150726
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-015-1758-0


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[PMID]:26007191
[Au] Autor:Shinobu-Mesquita CS; Bonfim-Mendonça PS; Moreira AL; Ferreira IC; Donatti L; Fiorini A; Svidzinski TI
[Ad] Endereço:Departamento Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Av. Colombo 5790, bloco T20, Maringá 87020-900, Brazil. cristianeshinobu@gmail.com.
[Ti] Título:Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.
[So] Source:Molecules;20(5):9405-18, 2015 May 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Vulvovaginal candidiasis (VVC) is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA) cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our group has reported the in vitro antifungal activity of extracts from Sapindus saponaria L. The present study used scanning electron microscopy and transmission electron microscopy to further evaluate the antifungal activity of hydroalcoholic extract from S. saponaria (HE) against yeast obtained from VVC and structural changes induced by HE. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. cerevisae. The results suggest that saponins that are present in HE act on the cell wall or membrane of yeast at the first moments after contact, causing damage to these structures and cell lysis.
[Mh] Termos MeSH primário: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/tratamento farmacológico
Extratos Vegetais/farmacologia
Saccharomyces cerevisiae/efeitos dos fármacos
Sapindus/metabolismo
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Candidíase Vulvovaginal/microbiologia
Membrana Celular/metabolismo
Parede Celular/metabolismo
Feminino
Seres Humanos
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); 0 (Saponins)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150526
[Lr] Data última revisão:
150526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150527
[St] Status:MEDLINE
[do] DOI:10.3390/molecules20059405



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