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Pesquisa : B01.650.940.800.575.912.250.888 [Categoria DeCS]
Referências encontradas : 125 [refinar]
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[PMID]:28278686
[Au] Autor:Li C; Li N; Yue J; Song Q; Fan Q
[Ad] Endereço:a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.
[Ti] Título:Two new lignans from Saururus chinensis.
[So] Source:Nat Prod Res;31(14):1598-1603, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new lignans, (Z)-14-bis(3',4'-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo-2-methyl-3-oxo-1-(3',4',5'-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3-17) were isolated from Saururus chinensis. Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activity was screened by MTT assay, compounds 1, 2, 3, 5, 9-11 and 13-15 showed no cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines.
[Mh] Termos MeSH primário: Lignanas/isolamento & purificação
Saururaceae/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Lignanas/química
Estrutura Molecular
Extratos Vegetais/química
Raízes de Plantas/química
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1286483


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[PMID]:27908800
[Au] Autor:Gao X; He J; Wu XD; Peng LY; Shao LD; Li Y; Cheng X; Zhao QS
[Ad] Endereço:College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, People's Republic of China.
[Ti] Título:Sauruchinenols A and B, unprecedented monocyclic diterpenes with new carbon skeleton from the aerial parts of Saururus chinensis.
[So] Source:Fitoterapia;116:116-120, 2017 Jan.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sauruchinenols A (1) and B (2), two novel monocyclic diterpenes with unique carbon skeleton, as well as two new structurally related diterpenes, sauruchinenols C (3) and D (4), were isolated from the aerial part of Saururus chinensis. Their structures were elucidated based on the analysis of spectroscopic data. A hypothetical biogenetic pathway for sauruchinenols A and B was proposed.
[Mh] Termos MeSH primário: Diterpenos/química
Componentes Aéreos da Planta/química
Saururaceae/química
[Mh] Termos MeSH secundário: Animais
Diterpenos/isolamento & purificação
Camundongos
Estrutura Molecular
Óxido Nítrico/metabolismo
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (sauruchinenol A); 0 (sauruchinenol B); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  3 / 125 MEDLINE  
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[PMID]:27618865
[Au] Autor:Lee JH; Lee JJ; Cho WK; Yim NH; Kim HK; Yun B; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu, 700-300, Republic of Korea.
[Ti] Título:KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats.
[So] Source:BMC Complement Altern Med;16:355, 2016 Sep 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: KBH-1 is an herbal mixture of Saururus chinensis, Curcuma longa and Polygala tenuifolia. Each herb has been reported to have various pharmaceutical activities; however, the synergistic effect of this herbal composition on obesity has not yet been determined. We investigated the alleviation effect of KBH-1 and its possible molecular mechanism in obesity-induced hepatic steatosis and leptin resistance in the hypothalamus. METHODS: We used HepG2 cells, primary neuronal cells and a high-fat diet (HFD)-induced obesity rat model to determine the effect of KBH-1 in vitro and in vivo on hepatic steatosis and leptin resistance accompanied by obesity. To identify the alleviation effect on lipid accumulation, HepG2 cells stimulated by FFA were stained with Oil Red O; in addition, immunoblotting and qPCR were performed to determine the effect of KBH-1 on the activation of proteins and nuclear enzymes in HepG2 cells and the steatotic liver of HFD-induced obesity rats. To examine the effect of KBH-1 on the leptin resistance of the hypothalamus and its possible molecular mechanism, we examined the effect of KBH-1 on the activation of the leptin resistance-related protein in primary cultured cortical neuron cells and the hypothalamus of an HFD-induced obesity rat model. In addition, we used HPLC analysis to identify the standard compound of KBH-1. RESULTS: KBH-1 not only suppressed the lipid deposition in HepG2 cells exposed to free fatty acids (FFA) but also significantly down-regulated major factors in lipogenesis and up-regulated major factors in lipolysis. Similarly, in a HFD-induced obesity model, KBH-1 improved hepatic steatosis by alleviating the effects on lipogenic genes and kinases. In addition, KBH-1 significantly improved the leptin-mediated signals impaired by obesity or FFA in the obesity model and primary cultured cortical neuron cells. In addition, KBH-1 was analyzed to include six standard compounds using HPLC analysis, among these compounds, onji-saponin B and curcumin were potently suppressed the level of triglycerides. CONCLUSIONS: KBH-1 exhibits alleviating effects by improving hepatic steatosis and leptin resistance by up-regulating the activation of AMPK and suppressing the expression of PPARγ. These findings show the potential of KBH-1 as a functional food supplement or preventive agent in the treatment of obesity.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Medicamentos de Ervas Chinesas/uso terapêutico
Fígado Gorduroso/tratamento farmacológico
Fígado Gorduroso/metabolismo
Resistência à Insulina
Leptina/metabolismo
[Mh] Termos MeSH secundário: Animais
Curcuma/química
Dieta Hiperlipídica
Células Hep G2
Seres Humanos
Masculino
Polygala/química
Ratos
Ratos Sprague-Dawley
Saururaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Leptin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170222
[Lr] Data última revisão:
170222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1265-z


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[PMID]:26949983
[Au] Autor:Xiao SJ; Guo DL; Zhang MS; Chen F; Ding LS; Zhou Y
[Ad] Endereço:a School of Pharmacy , Zunyi Medical Universty , Zunyi 563000 , China.
[Ti] Título:Three new oxazoline alkaloids from Gymnotheca chinensis.
[So] Source:J Asian Nat Prod Res;18(8):719-23, 2016 Aug.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three novel oxazoline alkaloids, 1-oxa-3-azaspiro [4.5] dec-2-ene-8-one (1), 1-oxa-3-azaspiro [4.5] dec-2, 6-diene-8-one (2), and 1-oxa-3-azaspiro [4.5] dec-10-methoxy-2, 6-diene-8-one (3) were isolated from the methanol extract of the whole plant of Gymnotheca chinensis. The chemical structures were established by means of spectroscopic analysis including one- and two-dimensional NMR spectroscopy.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Oxazóis/isolamento & purificação
Saururaceae/química
Compostos de Espiro/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Oxazóis/química
Compostos de Espiro/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-oxa-3-azaspiro(4.5)dec-10-methoxy-2,6-diene-8-one); 0 (1-oxa-3-azaspiro(4.5)dec-2,6-diene-8-one); 0 (1-oxa-3-azaspiro(4.5)dec-2-ene-8-one); 0 (Alkaloids); 0 (Oxazoles); 0 (Spiro Compounds)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1146255


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[PMID]:26872322
[Au] Autor:Xiao SJ; Guo DL; Xia B; Allen S; Gu YC; Chen F; Ding LS; Zhou Y
[Ad] Endereço:Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China.
[Ti] Título:Polycyclic Spiro Lignans and Biphenyl Tetrahydrofuranone Lignans from Gymnotheca involucrata.
[So] Source:Planta Med;82(8):723-8, 2016 May.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Four rare polycyclic spiro lignans (1-4) and four new biphenyl tetrahydrofuranone lignans (5-8) were isolated from the whole plant of Gymnotheca involucrata. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 was confirmed by single crystal X-ray diffraction. Bioassay results showed that compounds 2 and 6 exhibited weak antifungal activity against Uromyces viciae-fabae at 100 ppm in leaf-disc assays, while compound 3 demonstrated moderate insecticidal activity against Diabrotica balteata at 500 ppm in an artificial diet assay.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Lignanas/isolamento & purificação
Saururaceae/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Antifúngicos/farmacologia
Coleópteros/efeitos dos fármacos
Cristalografia por Raios X
Furanos/química
Furanos/isolamento & purificação
Furanos/farmacologia
Inseticidas/química
Inseticidas/isolamento & purificação
Lignanas/química
Lignanas/farmacologia
Testes de Sensibilidade Microbiana
Estrutura Molecular
Folhas de Planta/química
Compostos Policíclicos/química
Compostos Policíclicos/isolamento & purificação
Compostos Policíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Furans); 0 (Insecticides); 0 (Lignans); 0 (Polycyclic Compounds)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-100915


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[PMID]:26773771
[Au] Autor:Song JW; Seo CS; Cho ES; Kim TI; Won YS; Kwon HJ; Son JK; Son HY
[Ad] Endereço:Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
[Ti] Título:meso-Dihydroguaiaretic acid attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma.
[So] Source:Int Immunopharmacol;31:239-47, 2016 Feb.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:meso-Dihydroguaiaretic acid (MDGA), which is a dibenzylbutane lignin isolated from the ethyl acetate fraction of Saururus chinensis, has various biological activities, including anti-oxidative, anti-inflammatory, anti-bacterial, and neuroprotective effects. However, no report has examined the potential anti-asthmatic activity of MDGA. In this study, we evaluated the protective effects of MDGA on asthmatic responses, particularly airway inflammation and mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma. Intragastric administration of MDGA significantly lowered the productions of interleukin (IL)-4, IL-5, IL-13, tumor necrosis-α (TNF-α), eotaxin, monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), and immunoglobulin (Ig)E in bronchoalveolar lavage fluid (BALF), plasma, or lung tissues. Histological studies showed that MDGA inhibited OVA-induced inflammatory cell infiltration and mucus production in the respiratory tract. Moreover, MDGA markedly attenuated the OVA-induced activations of nuclear factor kappa B (NF-κB), extracellular-signal-regulated kinases 1/2 (ERK1/2), and p38 mitogen-activated protein kinase (p38 MAPK). Together, these results suggest that MDGA effectively inhibits airway inflammation and mucus hypersecretion by downregulating the levels of T helper 2 (Th2) cytokines, chemokines, and adhesion molecules, and inhibiting the activations of NF-κB and MAPKs.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Guaiacol/análogos & derivados
Lignanas/uso terapêutico
Pneumonia/tratamento farmacológico
Saururaceae/imunologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular/efeitos dos fármacos
Quimiocina CCL2/metabolismo
Citocinas/metabolismo
Feminino
Guaiacol/uso terapêutico
Seres Humanos
Imunoglobulina E/metabolismo
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Células Th2/imunologia
Molécula 1 de Adesão de Célula Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Cytokines); 0 (Lignans); 0 (NF-kappa B); 0 (Vascular Cell Adhesion Molecule-1); 36469-60-0 (dihydroguaiaretic acid); 37341-29-0 (Immunoglobulin E); 6JKA7MAH9C (Guaiacol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160117
[St] Status:MEDLINE


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[PMID]:26632199
[Au] Autor:Song JW; Seo CS; Kim TI; Moon OS; Won YS; Son HY; Son JK; Kwon HJ
[Ad] Endereço:Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University.
[Ti] Título:Protective Effects of Manassantin A against Ethanol-Induced Gastric Injury in Rats.
[So] Source:Biol Pharm Bull;39(2):221-9, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Manassantin A, a neolignan isolated from Saururus chinensis, is a major phytochemical compound that has various biological activities, including anti-inflammatory, neuroleptic, and human acyl-CoA : cholesterol acyltransferase (ACAT) inhibitory activities. In this study, we investigated the protective effects of manassantin A against ethanol-induced acute gastric injury in rats. Gastric injury was induced by intragastric administration of 5 mL/kg body weight of absolute ethanol to each rat. The positive control group and the manassantin A group were given oral doses of omeprazole (20 mg/kg) or manassantin A (15 mg/kg), respectively, 1 h prior to the administration of absolute ethanol. Our examinations revealed that manassantin A pretreatment reduced ethanol-induced hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Manassantin A pretreatment also attenuated the increased lipid peroxidation associated with ethanol-induced acute gastric lesions, increased the mucosal glutathione (GSH) content, and enhanced the activities of antioxidant enzymes. The levels of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1ß were clearly decreased in the manassantin A-pretreated group. In addition, manassantin A pretreatment enhanced the levels of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 (PGE2) and reduced the inducible nitric oxide synthase (iNOS) overproduction and nuclear factor kappa B (NF-κB) phosphorylation. Collectively, these results indicate that manassantin A protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.
[Mh] Termos MeSH primário: Antiulcerosos/farmacologia
Lignanas/farmacologia
Gastropatias/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/química
Catalase
Etanol
Glutationa
Lignanas/química
Masculino
Malondialdeído
Estrutura Molecular
Omeprazol/farmacologia
Ratos
Ratos Sprague-Dawley
Saururaceae/química
Gastropatias/prevenção & controle
Superóxido Dismutase
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Lignans); 3K9958V90M (Ethanol); 4Y8F71G49Q (Malondialdehyde); 88497-87-4 (manassantin A); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b15-00642


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[PMID]:26553125
[Au] Autor:Meng X; Kim I; Jeong YJ; Cho YM; Kang SC
[Ad] Endereço:Department of Life Science, Gachon University, Seongnam 461-701, Republic of Korea.
[Ti] Título:Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1.
[So] Source:Exp Biol Med (Maywood);241(4):396-408, 2016 Feb.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Saururus chinensis (Lour.) Baill. is a perennial plant distributed throughout Northeast Asia and its roots have been widely used as a traditional medicine for hepatitis, asthma, pneumonia, and gonorrhea. This study was designed to investigate the anti-inflammatory activity of an extract of S. chinensis of the aerial parts (rather than the root), and the signaling pathway responsible for this effect in lipopolysaccharide-stimulated murine macrophages. The subfraction 4 (SCF4) from the n-hexane layer of the ethanol extract of the aerial parts of S. chinensis exhibited the highest nitrite-inhibitory activity. SCF4 significantly inhibited the production of nitrite and the expression of pro-inflammatory mediators via heme oxygenase-1 upregulation. SCF4 caused significant phosphorylation of p38 MAPK and Akt, which subsequently induced the nuclear translocation of p-p65 nuclear factor-κB and Nrf2. SCF4 also suppressed the phosphorylation of signal transducers and activators of transcription 1 (p-STAT1). The heme oxygenase-1 inhibitor zinc protoporphyrin attenuated the inhibitory effect of SCF4 on lipopolysaccharide-stimulated nitrite production and expression of inflammatory mediators, tumor necrosis factor alpha, and p-STAT1. We identified sauchinone as the active compound in S. chinensis extract and SCF4. Sauchinone was shown to significantly inhibit nitrite production and inflammatory mediators expression via heme oxygenase-1 upregulation. These results suggest that S. chinensis extract, SCF4, and its active compound, sauchinone, could be used as an anti-inflammatory agent.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzopiranos/farmacologia
Dioxóis/farmacologia
Ativação Enzimática
Heme Oxigenase-1/biossíntese
Macrófagos/imunologia
Extratos Vegetais/farmacologia
Saururaceae/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Benzopiranos/isolamento & purificação
Linhagem Celular
Dioxóis/isolamento & purificação
Mediadores da Inflamação/análise
Macrófagos/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Nitritos/análise
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzopyrans); 0 (Dioxoles); 0 (Inflammation Mediators); 0 (Nitrites); 0 (Plant Extracts); 0 (sauchinone); EC 1.14.14.18 (Heme Oxygenase-1)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151111
[St] Status:MEDLINE
[do] DOI:10.1177/1535370215614657


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[PMID]:27352534
[Au] Autor:Zuo YM; Xu YL; Zhang ZL; Liu DH; Cai MT
[Ti] Título:[Chemical Constituents from Saururus chinensis].
[So] Source:Zhong Yao Cai;38(12):2538-40, 2015 Dec.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the chemical constituents of active components of Saururus chinensis on anti-nicotine withdrawal symptoms. METHODS: Various column chromatography were used in the isolation and purification, and physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. RESULTS: Six chemical compounds were isolated from the active part of anti-withdrawal symptoms, and were identified as 4'-hydroxyl-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan (1) ,3-(2-nitroethyl)-1-methoxyindole(2), elemicin (3), erythro-(7R, 8S) - (-) - (3,4,5-trimethoxy-7-hydroxy-1'-allyl-3', 5'-dimethoxy)-8-O-4'-neolignan (4), 3,4,5-trimethoxy-phenylacrylaldehyde (5) and dibutyl phthalate (6). CONCLUSION: Compound 1 is a novel lignan, compounds 2 - 6 are firstly isolated from this plant.
[Mh] Termos MeSH primário: Compostos Fitoquímicos/análise
Plantas Medicinais/química
Saururaceae/química
[Mh] Termos MeSH secundário: Lignanas/análise
Nicotina
Síndrome de Abstinência a Substâncias
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (Phytochemicals); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160629
[Lr] Data última revisão:
160629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE


  10 / 125 MEDLINE  
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[PMID]:26116884
[Au] Autor:Lee AY; Han YA; Kim JE; Hong SH; Park EJ; Cho MH
[Ad] Endereço:Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National, University, Seoul 151-742, Republic of Korea.
[Ti] Título:Saururus chinensis Baill induces apoptosis through endoplasmic reticulum stress in HepG2 hepatocellular carcinoma cells.
[So] Source:Food Chem Toxicol;83:183-92, 2015 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we examined the mechanism underlying the effect of Saururus chinensis Baill (saururaceae) on hepatocellular carcinoma HepG2 cells. HepG2 cells and Chang cells were exposed to various concentrations of S. chinensis Baill extract (SC-E) for 24 h. SC-E affected more significantly HepG2 cells than Chang cells in terms of cell viability and ATP production. Therefore, current study examined detailed mechanism how SC-E affected HepG2 cell survival. We found that SC-E (75 and 150 µg/ml) induced apoptosis via oxidative stress. SC-E also caused CCAAT-enhancer-binding protein homologous protein (CHOP) activation by dissociating the binding immunoglobulin protein (BiP) from inositol-requiring 1α (IRE1α) in the endoplasmic reticulum (ER) and induced Bax, cytochrome c release to cytosol, caspase-3 activation, and poly ADP ribose polymerase (PARP) cleavage, resulting in HepG2 cell apoptosis. Furthermore, SC-E caused ER Ca(2+) leakage into the cytosol; ER dilation and mitochondrial membrane damage were observed in transmission electron microscopy (TEM). Taken together, our results demonstrated that SC-E induced cancer cell apoptosis specifically through ER stress.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Neoplasias Hepáticas/tratamento farmacológico
Extratos Vegetais/farmacologia
Saururaceae/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/efeitos adversos
Sinalização do Cálcio/efeitos dos fármacos
Carcinoma Hepatocelular/metabolismo
Carcinoma Hepatocelular/ultraestrutura
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Núcleo Celular/ultraestrutura
Sobrevivência Celular/efeitos dos fármacos
Retículo Endoplasmático/efeitos dos fármacos
Retículo Endoplasmático/metabolismo
Retículo Endoplasmático/ultraestrutura
Metabolismo Energético/efeitos dos fármacos
Células Hep G2
Hepatócitos/efeitos dos fármacos
Seres Humanos
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/ultraestrutura
Medicina Tradicional do Leste Asiático
Microscopia Eletrônica de Transmissão
Membranas Mitocondriais/efeitos dos fármacos
Membranas Mitocondriais/metabolismo
Membranas Mitocondriais/ultraestrutura
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/efeitos adversos
República da Coreia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150817
[Lr] Data última revisão:
150817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150628
[St] Status:MEDLINE



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