Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.889 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:26930483
[Au] Autor:Zhang L; Xiang L; Liu Y; Venkatraman P; Chong L; Cho J; Bonilla S; Jin ZB; Pang CP; Ko KM; Ma P; Zhang M; Leung YF
[Ad] Endereço:Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN, 47907, United States of America.
[Ti] Título:A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration.
[So] Source:PLoS One;11(3):e0149663, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retinal degeneration is often progressive. This feature has provided a therapeutic window for intervention that may extend functional vision in patients. Even though this approach is feasible, few promising drug candidates are available. The scarcity of new drugs has motivated research to discover novel compounds through different sources. One such example is Schisandrin B (SchB), an active component isolated from the five-flavor fruit (Fructus Schisandrae) that is postulated in traditional Chinese medicines to exert prophylactic visual benefit. This SchB benefit was investigated in this study in pde6cw59, a zebrafish retinal-degeneration model. In this model, the pde6c gene (phosphodiesterase 6C, cGMP-specific, cone, alpha prime) carried a mutation which caused cone degeneration. This altered the local environment and caused the bystander rods to degenerate too. To test SchB on the pde6cw59 mutants, a treatment concentration was first determined that would not cause morphological defects, and would initiate known physiological response. Then, the mutants were treated with the optimized SchB concentration before the appearance of retinal degeneration at 3 days postfertilization (dpf). The light sensation of animals was evaluated at 6 dpf by the visual motor response (VMR), a visual startle that could be initiated by drastic light onset and offset. The results show that the VMR of pde6cw59 mutants towards light onset was enhanced by the SchB treatment, and that the initial phase of the enhancement was primarily mediated through the mutants' eyes. Further immunostaining analysis indicates that the treatment specifically reduced the size of the abnormally large rods. These observations implicate an interesting hypothesis: that the morphologically-improved rods drive the observed VMR enhancement. Together, these investigations have identified a possible visual benefit of SchB on retinal degeneration, a benefit that can potentially be further developed to extend functional vision in patients.
[Mh] Termos MeSH primário: Lignanas/uso terapêutico
Compostos Policíclicos/uso terapêutico
Degeneração Retiniana/tratamento farmacológico
Células Fotorreceptoras Retinianas Bastonetes/efeitos dos fármacos
Visão Ocular/efeitos dos fármacos
Peixe-Zebra
[Mh] Termos MeSH secundário: Animais
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/genética
Ciclo-Octanos/química
Ciclo-Octanos/uso terapêutico
Modelos Animais de Doenças
Larva/efeitos dos fármacos
Lignanas/química
Mutação
Compostos Policíclicos/química
Degeneração Retiniana/genética
Degeneração Retiniana/metabolismo
Degeneração Retiniana/patologia
Células Fotorreceptoras Retinianas Bastonetes/patologia
Schisandraceae/química
Peixe-Zebra/crescimento & desenvolvimento
Peixe-Zebra/fisiologia
Proteínas de Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Cyclooctanes); 0 (Lignans); 0 (Polycyclic Compounds); 0 (Zebrafish Proteins); 02XA4X3KZW (schizandrin B); EC 3.1.4.- (Pde6c protein, zebrafish); EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 6)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0149663


  2 / 27 MEDLINE  
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[PMID]:26329870
[Au] Autor:Kim HM; Ryu B; Lee JS; Choi JH; Jang DS
[Ad] Endereço:College of Pharmacy, Kyung Hee University.
[Ti] Título:Schisandrosides A-D, Dibenzocyclooctadiene Lignan Glucosides from the Roots of Schisandra chinensis.
[So] Source:Chem Pharm Bull (Tokyo);63(9):746-51, 2015.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Four new dibenzocyclooctadiene lignan glucosides, schisandrosides A-D (1-4), as well as two known rare nortriterpenoids, micrandilactone C (5) and propindilactone Q (6), were isolated from the roots of Schisandra chinensis BAILLON (Schisandraceae). The structure of compounds 1-4 were elucidated by physical and spectroscopic data interpretation. To the best of our knowledge, schisandrosides A-D (1-4) represent the first example of a dibenzocyclooctadiene lignan glycoside.
[Mh] Termos MeSH primário: Ciclo-Octanos/química
Glucosídeos/química
Lignanas/química
Extratos Vegetais/química
Raízes de Plantas/química
Schisandraceae/química
[Mh] Termos MeSH secundário: Ciclo-Octanos/isolamento & purificação
Glucosídeos/isolamento & purificação
Lignanas/isolamento & purificação
Conformação Molecular
Extratos Vegetais/isolamento & purificação
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclooctanes); 0 (Glucosides); 0 (Lignans); 0 (Plant Extracts); 0 (dibenzocyclooctadiene lignan)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150902
[Lr] Data última revisão:
150902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150903
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c15-00400


  3 / 27 MEDLINE  
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[PMID]:25938480
[Au] Autor:Zhang J; Chen M; Dong X; Lin R; Fan J; Chen Z
[Ad] Endereço:State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, P.R. China.
[Ti] Título:Evaluation of four commonly used DNA barcoding Loci for chinese medicinal plants of the family schisandraceae.
[So] Source:PLoS One;10(5):e0125574, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many species of Schisandraceae are used in traditional Chinese medicine and are faced with contamination and substitution risks due to inaccurate identification. Here, we investigated the discriminatory power of four commonly used DNA barcoding loci (ITS, trnH-psbA, matK, and rbcL) and corresponding multi-locus combinations for 135 individuals from 33 species of Schisandraceae, using distance-, tree-, similarity-, and character-based methods, at both the family level and the genus level. Our results showed that the two spacer regions (ITS and trnH-psbA) possess higher species-resolving power than the two coding regions (matK and rbcL). The degree of species resolution increased with most of the multi-locus combinations. Furthermore, our results implied that the best DNA barcode for the species discrimination at the family level might not always be the most suitable one at the genus level. Here we propose the combination of ITS+trnH-psbA+matK+rbcL as the most ideal DNA barcode for discriminating the medicinal plants of Schisandra and Kadsura, and the combination of ITS+trnH-psbA as the most suitable barcode for Illicium species. In addition, the closely related species Schisandra rubriflora Rehder & E. H. Wilson and Schisandra grandiflora Hook.f. & Thomson, were paraphyletic with each other on phylogenetic trees, suggesting that they should not be distinct species. Furthermore, the samples of these two species from the southern Hengduan Mountains region formed a distinct cluster that was separated from the samples of other regions, implying the presence of cryptic diversity. The feasibility of DNA barcodes for identification of geographical authenticity was also verified here. The database and paradigm that we provide in this study could be used as reference for the authentication of traditional Chinese medicinal plants utilizing DNA barcoding.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico/métodos
Loci Gênicos
Plantas Medicinais/genética
Schisandraceae/genética
[Mh] Termos MeSH secundário: DNA de Plantas/genética
Filogenia
Análise de Sequência de DNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150505
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0125574


  4 / 27 MEDLINE  
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[PMID]:25483912
[Au] Autor:Shi YM; Xiao WL; Pu JX; Sun HD
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China. hdsun@mail.kib.ac.cn.
[Ti] Título:Triterpenoids from the Schisandraceae family: an update.
[So] Source:Nat Prod Rep;32(3):367-410, 2015 Mar.
[Is] ISSN:1460-4752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several significant advances in the field of phytochemistry were made between 2008 and 2014 because of the high level of interest in Schisandraceae triterpenoids. In addition to a dramatic increase in the number of newly identified triterpenoids, the first complete synthesis of a schinortriterpenoid was accomplished. There has also been substantial progress in investigations of biological activity and mechanism of action. In this update, we review more than 250 new triterpenoids and describe their structures, classifications, biogenetic pathways, syntheses, and bioactivities.
[Mh] Termos MeSH primário: Schisandraceae/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Estrutura Molecular
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Triterpenes)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150226
[Lr] Data última revisão:
150226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141209
[St] Status:MEDLINE
[do] DOI:10.1039/c4np00117f


  5 / 27 MEDLINE  
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[PMID]:23583286
[Au] Autor:Han YS; Xiao WL; Quashie PK; Mesplède T; Xu H; Deprez E; Delelis O; Pu JX; Sun HD; Wainberg MA
[Ad] Endereço:McGill University AIDS Centre, Lady Davis for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
[Ti] Título:Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.
[So] Source:Antiviral Res;98(3):441-8, 2013 Jun.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Human immunodeficiency virus integrase (HIV-1 IN) inhibitors that are currently approved or are in advanced clinical trials specifically target the strand transfer step of integration. However, considerable cross-resistance exists among some members of this class of IN inhibitors. Intriguingly, though, HIV-1 IN possesses multiple sites, distinct from those involved in the strand transfer step, that could be targeted to develop new HIV-1 IN inhibitors. We have developed a fluorescent HIV-1 IN DNA binding assay that can identify small molecules termed IN binding inhibitors (INBIs) that inhibit IN binding to viral DNA. This assay has been optimized with respect to concentrations of each protein, long terminal repeat (LTR) DNA substrate, salt, and time, and has been used successfully to measure the HIV-1 IN DNA binding activity of a well-characterized INBI termed FZ41. In addition, we have used the assay to screen a small library of natural products, resulting in the identification of nigranoic acid as a new INBI. The proposed fluorescence assay is easy and inexpensive, and provides a high-throughput detection method for determination of HIV-1 IN DNA binding activity, monitoring of enzyme kinetics, and high-throughput screening for the identification of new INBIs.
[Mh] Termos MeSH primário: DNA Viral/metabolismo
Inibidores de Integrase de HIV/isolamento & purificação
Integrase de HIV/metabolismo
HIV-1/enzimologia
Ensaios de Triagem em Larga Escala/métodos
[Mh] Termos MeSH secundário: Ligação Competitiva
Fluorescência
Corantes Fluorescentes/metabolismo
Integrase de HIV/genética
Inibidores de Integrase de HIV/metabolismo
Repetição Terminal Longa de HIV
HIV-1/genética
Ligação Proteica
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Schisandraceae/metabolismo
Sensibilidade e Especificidade
Sesquiterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Fluorescent Dyes); 0 (HIV Integrase Inhibitors); 0 (Recombinant Proteins); 0 (Sesquiterpenes); 0 (Triterpenes); 0 (nigranoic acid); EC 2.7.7.- (HIV Integrase)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130522
[Lr] Data última revisão:
130522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130416
[St] Status:MEDLINE


  6 / 27 MEDLINE  
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[PMID]:22860441
[Au] Autor:Liu H; Qi Y; Xu L; Peng Y; Zhang B; Xiao P
[Ad] Endereço:Key Laboratory of Bioactive Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
[Ti] Título:[Ethno-pharmacological investigation of Schisandraceae plants in China].
[So] Source:Zhongguo Zhong Yao Za Zhi;37(10):1353-9, 2012 May.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate and arrange the ethno-pharmacological information of Schisandraceae plants in China. METHOD: The information was obtained by literature search, specimen inspection, field resource investigation and samples collection. RESULT: Twenty-six Schisandraece plants (inlcuding 4 varieties) have been used as folk medicines in different regions of China, the identical medicinal parts of different species in one genus show the similar usage, action and indications, and different medicinal parts with different administrated ways show different action and indications. CONCLUSION: The results provide reliable information for resource development and comprehensive utilization of Schisandraece plant resource in China.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Schisandraceae
[Mh] Termos MeSH secundário: China
Etnofarmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:120806
[Lr] Data última revisão:
120806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120807
[St] Status:MEDLINE


  7 / 27 MEDLINE  
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[PMID]:21895737
[Au] Autor:Leong PK; Chen N; Ko KM
[Ad] Endereço:Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
[Ti] Título:Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases.
[So] Source:Clin Exp Pharmacol Physiol;39(3):256-64, 2012 Mar.
[Is] ISSN:1440-1681
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:1. The mitochondrial free radical theory of ageing (MFRTA) proposes a primary role for mitochondrial reactive oxygen species (ROS) in the ageing process. The reductive hot spot hypothesis of mammalian ageing serves as a supplement to the MFRTA by explaining how the relatively few cells that have lost oxidative phosphorylation capacity due to mitochondrial DNA mutations can be toxic to the rest of the body and result in the development of age-related diseases. 2. Schisandrin B (SchB), which can induce both a glutathione anti-oxidant and a heat shock response via redox-sensitive signalling pathways, is a hormetic agent potentially useful for increasing the resistance of tissues to oxidative damage. The enhanced cellular/mitochondrial anti-oxidant status and heat shock response afforded by SchB can preserve the structural and functional integrity of mitochondria, suggesting a potential role for SchB in ameliorating age-related diseases. 3. Future studies will focus on investigating whether SchB can produce the hormetic response in humans.
[Mh] Termos MeSH primário: Envelhecimento/metabolismo
Hormese/fisiologia
Lignanas/farmacologia
Mitocôndrias/metabolismo
Compostos Policíclicos/farmacologia
Qi
Schisandraceae
[Mh] Termos MeSH secundário: Envelhecimento/efeitos dos fármacos
Envelhecimento/patologia
Animais
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Ciclo-Octanos/farmacologia
Ciclo-Octanos/uso terapêutico
Hormese/efeitos dos fármacos
Seres Humanos
Lignanas/uso terapêutico
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Compostos Policíclicos/uso terapêutico
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cyclooctanes); 0 (Lignans); 0 (Polycyclic Compounds); 0 (Reactive Oxygen Species); 02XA4X3KZW (schizandrin B)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110908
[St] Status:MEDLINE
[do] DOI:10.1111/j.1440-1681.2011.05600.x


  8 / 27 MEDLINE  
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[PMID]:22013615
[Au] Autor:Yan B; A JY; Hao HP; Wang GJ; Liu LS; Zha WB; Zhang Y; Gu SH
[Ad] Endereço:Department of Clinical Pharmacology, Beijing Hospital, Ministry of Health, Beijing 100730, China.
[Ti] Título:[Metabonomic phenotype of "formula corresponding to pattern types" based on "qi and yin deficiency pattern" of myocardial ischemia rat model].
[So] Source:Yao Xue Xue Bao;46(8):976-82, 2011 Aug.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:In order to explore the scientific connotation of "Fangzhengduiying (formula corresponding to pattern types)", "Qiyinliangxuzheng (Qi and Yin deficiency pattern)" of myocardial ischemia rat model and GC-TOF/MS based metabonomic method were used for comparing the effects of Sheng-mai injection, Salvia injection and propranolol in the present study. After data processing and pattern recognition, Sheng-mai injection showed better efficacy than the other two drugs in accordance with not only visual observation from PLS-DA scores plots but also the number of abnormal endogenous compounds restored to the normal level. Further studies showed that Sheng-mai injection could normalize the level of plasma endothelin-1, the index related to cardiovascular diseases and sleep disorders, which verified the results of metabonomics. Finally, the regulated metabolites and related metabolic pathways were analyzed, and it was supposed that the effects of Sheng-mai injection involved in the alternation of energy metabolism, lipid metabolism, amino acids metabolism, and so on. These findings provided scientific evidence to Shengmai "Fang" used for "Qi and Yin deficiency pattern" correspondingly, indicating that metabonomics has great potential in traditional Chinese medical research, which provides a novel approach and way to modernization of traditional Chinese medicine.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Endotelina-1/sangue
Medicina Tradicional Chinesa
Isquemia Miocárdica/metabolismo
Qi
Deficiência da Energia Yin/metabolismo
[Mh] Termos MeSH secundário: Animais
Antiarrítmicos/farmacologia
Combinação de Medicamentos
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/isolamento & purificação
Cromatografia Gasosa-Espectrometria de Massas/métodos
Injeções
Masculino
Metabolômica/métodos
Isquemia Miocárdica/sangue
Isquemia Miocárdica/patologia
Panax/química
Plantas Medicinais/química
Propranolol/farmacologia
Ratos
Ratos Sprague-Dawley
Salvia/química
Schisandraceae/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 0 (Drug Combinations); 0 (Drugs, Chinese Herbal); 0 (Endothelin-1); 0 (fructus schizandrae, radix ginseng, radix ophiopogonis drug combination); 9Y8NXQ24VQ (Propranolol)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111022
[St] Status:MEDLINE


  9 / 27 MEDLINE  
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[PMID]:21739547
[Au] Autor:Xiao Q; Ren WW; Chen ZX; Sun TW; Li Y; Ye QD; Gong JX; Meng FK; You L; Liu YF; Zhao MZ; Xu LM; Shan ZH; Shi Y; Tang YF; Chen JH; Yang Z
[Ad] Endereço:Department of Chemistry, Peking University, HaiDian District, Beijing, China.
[Ti] Título:Diastereoselective total synthesis of (±)-schindilactone A.
[So] Source:Angew Chem Int Ed Engl;50(32):7373-7, 2011 Aug 01.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Lactonas/química
Triterpenos/síntese química
[Mh] Termos MeSH secundário: Catálise
Cobalto/química
Cristalografia por Raios X
Ciclização
Lactonas/síntese química
Conformação Molecular
Paládio/química
Schisandraceae/química
Estereoisomerismo
Tioureia/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lactones); 0 (Triterpenes); 0 (schindilactone A); 3G0H8C9362 (Cobalt); 5TWQ1V240M (Palladium); GYV9AM2QAG (Thiourea)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110709
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201103088


  10 / 27 MEDLINE  
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[PMID]:21351433
[Au] Autor:Peng ZG; Xu LJ; Ye WC; Xiao PG; Chen HS
[Ad] Endereço:Institute of Medicinal and Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
[Ti] Título:[Effective components against HIV-1 replicative enzymes isolated from plants].
[So] Source:Yao Xue Xue Bao;45(2):235-40, 2010 Feb.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Plant active components characterized of many different structures and activities on multiple targets, have made them to be the important sources of inhibitors on HIV-1. For finding leading compounds with new structure against HIV-1, three key HIV-1 replicative enzymes (reverse transcriptase, protease and integrase) were used as screening models. The in vitro activities of 45 plant derived components isolated from Schisandraceae, Rutaceae and Ranunculaceae were reported. Within twelve triterpene components isolated, eight compounds were found to inhibit HIV-1 protease, in these eight active compounds, kadsuranic acid A (7) and nigranoic acid (8), inhibited both HIV-1 protease and integrase; Among fifteen lignans, meso-dihydroguaiaretic acid (15) and kadsurarin (16) were active on HIV-1 reverse transcriptase, and 4, 4-di(4-hydroxy-3-methoxyphenly)-2, 3-dimethylbutanol (13) active on HIV-1 integrase. All of the six alkaloids, seven flavones, and five others compounds were not active or only with low activities against HIV-1 replicative enzymes. Further studies of the triterpene components showing strong inhibitory activities on HIV-1 were warranted.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Integrase de HIV/efeitos dos fármacos
Protease de HIV/efeitos dos fármacos
Transcriptase Reversa do HIV/antagonistas & inibidores
Plantas Medicinais
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Fármacos Anti-HIV/química
Fármacos Anti-HIV/isolamento & purificação
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Flavonas/química
Flavonas/isolamento & purificação
Flavonas/farmacologia
Guaiacol/análogos & derivados
Guaiacol/química
Guaiacol/isolamento & purificação
Guaiacol/farmacologia
Lignanas/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
Plantas Medicinais/química
Ranunculaceae/química
Rutaceae/química
Schisandraceae/química
Triterpenos/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-HIV Agents); 0 (Drugs, Chinese Herbal); 0 (Flavones); 0 (Lignans); 0 (Triterpenes); 0 (nigranoic acid); 36469-60-0 (dihydroguaiaretic acid); 6JKA7MAH9C (Guaiacol); EC 2.7.7.- (HIV Integrase); EC 2.7.7.49 (HIV Reverse Transcriptase); EC 3.4.23.- (HIV Protease)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110301
[St] Status:MEDLINE



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