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Pesquisa : B01.650.940.800.575.912.250.898 [Categoria DeCS]
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[PMID]:27169286
[Au] Autor:Xiao H; Zheng RR; Zhang J; Song M; Gao XD; Zhang XQ; Ye WC
[Ti] Título:[Chemical constituents from the twigs and leaves of Harrisonia perforate].
[So] Source:Yao Xue Xue Bao;50(12):1622-4, 2015 Dec.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:This study was performed to investigate the chemical constituents in the twigs and leaves of Harrisonia perforate. Six compounds were isolated from the 95% EtOH extract of the twigs and leaves of Harrisonia perforate by silica gel, ODS, Sephadex LH-20 column chromatographies and preparative HPLC. On the basis of chemical properties and spectra data, these compounds were identified as harriperfin E (1), kihadanin A (2), kihadanin B (3), 6α-acetoxyobacunol acetate (4), gardaubryone C (5), and ß-sitosterol methyl ether (6), respectively. Compound 1 is a new chromone, and compounds 2-6 are isolated from this plant for the first time.
[Mh] Termos MeSH primário: Compostos Fitoquímicos/química
Folhas de Planta/química
Simaroubaceae/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/química
Compostos Fitoquímicos/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Phytochemicals)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160512
[Lr] Data última revisão:
160512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE


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[PMID]:25810025
[Au] Autor:Fang X; Di YT; Zhang Y; Xu ZP; Lu Y; Chen QQ; Zheng QT; Hao XJ
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan (PR China).
[Ti] Título:Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata.
[So] Source:Angew Chem Int Ed Engl;54(19):5592-5, 2015 May 04.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Perforalactone A (1), a new 20S quassinoid with a unique cagelike 2,4-dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X-ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid-type natural products are also discussed.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Coleópteros/efeitos dos fármacos
Inseticidas/farmacologia
Quassinas/farmacologia
Receptores Nicotínicos/metabolismo
Simaroubaceae/química
[Mh] Termos MeSH secundário: Animais
Produtos Biológicos/química
Produtos Biológicos/metabolismo
Relação Dose-Resposta a Droga
Drosophila melanogaster/química
Drosophila melanogaster/metabolismo
Inseticidas/química
Inseticidas/metabolismo
Conformação Molecular
Quassinas/biossíntese
Quassinas/química
Simaroubaceae/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biological Products); 0 (Insecticides); 0 (Quassins); 0 (Receptors, Nicotinic)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150327
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201412126


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[PMID]:25667960
[Au] Autor:Silva RL; Lopes AH; França RO; Vieira SM; Silva EC; Amorim RC; Cunha FQ; Pohlit AM; Cunha TM
[Ad] Endereço:Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo , São Paulo, Brazil.
[Ti] Título:The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
[So] Source:J Nat Prod;78(2):241-9, 2015 Feb 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isobrucein B (1) is a quassinoid isolated from the Amazonian medicinal plant Picrolemma sprucei. Herein we investigate the anti-inflammatory and antihyperalgesic effects of this quassinoid. Isobrucein B (1) (0.5-5 mg/kg) inhibited carrageenan-induced inflammatory hyperalgesia in mice in a dose-dependent manner. Reduced hyperalgesia was associated with reduction in both neutrophil migration and pronociceptive cytokine production. Pretreatment with 1 inhibited in vitro production/release of cytokines TNF, IL-1ß, and KC/CXCL1 by lipopolysaccharide-stimulated macrophages. To investigate its molecular mechanism, RAW 264.7 macrophages with a luciferase reporter gene controlled by the NF-κB promoter were used (RAW 264.7-Luc). Quassinoid 1 reduced the luminescence emission by RAW 264.7-Luc stimulated by different compounds. Unexpectedly, NF-κB translocation to macrophage nuclei was not inhibited by 1 when evaluated by Western blotting and immunofluorescence. Furthermore, quassinoid 1 did not change the levels of TNF mRNA transcription in stimulated macrophages, suggesting post-transcriptional modulation. In addition, constitutive expression of luciferase in RAW 264.7 cells transiently transfected with a plasmid containing a universal promoter was inhibited by 1. Thus, isobrucein B (1) displays anti-inflammatory and antihyperalgesic activities by nonselective post-transcriptional modulation, resulting in decreased production/release of pro-inflammatory cytokines and neutrophil migration.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Hiperalgesia/tratamento farmacológico
Plantas Medicinais/química
Quassinas/farmacologia
Simaroubaceae/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Brasil
Carragenina/efeitos adversos
Ciclo-Oxigenase 2/metabolismo
Dinoprostona/metabolismo
Proteínas I-kappa B/efeitos dos fármacos
Inflamação/induzido quimicamente
Interleucina-1beta/metabolismo
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Masculino
Camundongos
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Estrutura Molecular
NF-kappa B/metabolismo
Óxido Nítrico/biossíntese
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Peroxidase/metabolismo
Quassinas/química
Fator de Necrose Tumoral alfa/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (I-kappa B Proteins); 0 (Interleukin-1beta); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Quassins); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); 53663-03-9 (isobrucein B); 9000-07-1 (Carrageenan); EC 1.11.1.7 (Peroxidase); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.99.1 (Cyclooxygenase 2); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150227
[Lr] Data última revisão:
150227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150211
[St] Status:MEDLINE
[do] DOI:10.1021/np500796f


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[PMID]:25518297
[Au] Autor:Sakpakdeejaroen I; Juckmeta T; Itharat A
[Ti] Título:Development and validation of RP-HPLC method to determine anti-allergic compound in Thai traditional remedy called Benjalokawichien.
[So] Source:J Med Assoc Thai;97 Suppl 8:S76-80, 2014 Aug.
[Is] ISSN:0125-2208
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:Benjalokawichien (BLW) or Ya-Ha-Rak (HR) is a traditional remedy in the Nationaldrug list of herbal medicinal products AD 2012 of Thailand. For traditional use, BLW is used as antipyretic agent. It also has anti-allergic effect, particularly treating allergic rash. The ethanolic extract of BLW exhibited anti-allergic activity via inhibitory effect against a release ofbeta-hexosaminidase in RBL-2H3 cell line. Pectolinarigenin has been identified as the active compound ofBLW extract. In this study, a reversed-phase high performance liquid chromatography (RP-HPLC) method was developed in order to control quality ofpreparation in three aspects such as chemical fingerprint, quantification and stability of the ethanolic extract. The RP-HPLC was performed with a gradient mobile phase composed of 0.1% ortho phosphoric acid and acetronitrile, and peaks were detected at 331 nm. Based on validation results, this analytical method is precise, accurate and stable for quantitative determination ofpectolinarigenin. The amount ofpectolinarigenin in Benjalokawichien extract determined by this method was 18.50 mg/g ofextract. Therefore, this method could be consideredfor quality control ofBLWextract.
[Mh] Termos MeSH primário: Antialérgicos/química
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia de Fase Reversa/métodos
Preparações de Plantas/química
[Mh] Termos MeSH secundário: Capparis/química
Cromonas/química
Clerodendrum/química
Ficus/química
Seres Humanos
Menispermaceae/química
Raízes de Plantas/química
Controle de Qualidade
Simaroubaceae/química
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Chromones); 0 (Plant Preparations); 0 (pectolinarigenin)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:141218
[Lr] Data última revisão:
141218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141219
[St] Status:MEDLINE


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[PMID]:25001554
[Au] Autor:Lee WJ; Moon JS; Kim SI; Kim YT; Nash O; Bahn YS; Kim SU
[Ad] Endereço:Division of Biosystems Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
[Ti] Título:Inhibition of the calcineurin pathway by two tannins, chebulagic acid and chebulanin, isolated from Harrisonia abyssinica Oliv.
[So] Source:J Microbiol Biotechnol;24(10):1377-81, 2014 Oct.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:In order to discover and develop novel signaling inhibitors from plants, a screening system was established targeting the two-component system of Cryptococcus neoformans by using the wild type and a calcineurin mutant of C. neoformans, based on the counter-regulatory action of high-osmolarity glycerol (Hog1) mitogen-activated protein kinase and the calcineurin pathways in C. neoformans. Among 10,000 plant extracts, that from Harrisonia abyssinica Oliv. exhibited the most potent inhibitory activity against C. neoformans var. grubii H99 with fludioxonil. Bioassay-guided fractionation was used to isolate two bioactive compounds from H. abyssinica, and these compounds were identified as chebulagic acid and chebulanin using spectroscopic methods. These compounds specifically inhibited the calcineurin pathway in C. neoformans. Moreover, they exhibited potent antifungal activities against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 µg/ml.
[Mh] Termos MeSH primário: Benzopiranos/metabolismo
Calcineurina/metabolismo
Cryptococcus neoformans/enzimologia
Inibidores Enzimáticos/metabolismo
Glucosídeos/metabolismo
Taninos Hidrolisáveis/metabolismo
Simaroubaceae/química
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Antifúngicos/metabolismo
Benzopiranos/isolamento & purificação
Bioensaio/métodos
Cryptococcus neoformans/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos/métodos
Inibidores Enzimáticos/isolamento & purificação
Glucosídeos/isolamento & purificação
Taninos Hidrolisáveis/isolamento & purificação
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Benzopyrans); 0 (Enzyme Inhibitors); 0 (Glucosides); 0 (Hydrolyzable Tannins); 0 (chebulanin); 23094-71-5 (chebulagic acid); EC 3.1.3.16 (Calcineurin)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:160613
[Lr] Data última revisão:
160613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140709
[St] Status:MEDLINE


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[PMID]:24705958
[Au] Autor:Park MH; Kim IS; Dong MS; Yoo HH
[Ad] Endereço:Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Gyeonggi-do, 426-791, South Korea.
[Ti] Título:Development of an LC-MS/MS method for aromatase inhibitor screening.
[So] Source:Anal Bioanal Chem;406(14):3443-9, 2014 May.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aromatase (CYP 19A1) is a key steroidogenic enzyme that catalyzes the conversion of androgen to estrogen. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for aromatase inhibitor screening was developed and validated. The substrate androstenedione was incubated with human CYP 19A1 supersomes in the presence of NADPH for 30 min, and estrone formation was determined by LC-MS/MS analysis. Cortisone was used as internal standard. The incubation mixture was extracted using a liquid-liquid extraction method with ethyl acetate. Chromatographic separation was achieved using a C18 column (3.0 × 50 mm, 2.7 µm) with a mobile phase consisting of 0.1% formic acid/acetonitrile adopting gradient elution at a flow rate of 0.4 mL/min. The mass spectrometer was operated in positive electrospray ionization mode. The precursor-product ion pairs used for multiple reaction monitoring were m/z 287→97 (androstenedione), m/z 271 → 159 (estrone), and m/z 361 → 163 (IS, cortisone). The developed method met the required criteria for the validation of bioanalytical methods. The validated method was successfully applied to evaluate aromatase inhibitory activity of plants extracts of Simaroubaceae.
[Mh] Termos MeSH primário: Inibidores da Aromatase/análise
Aromatase/química
Cromatografia Líquida/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cortisona/química
Relação Dose-Resposta a Droga
Ensaio de Imunoadsorção Enzimática
Estrona/química
Seres Humanos
Extração Líquido-Líquido
Extratos Vegetais
Reprodutibilidade dos Testes
Simaroubaceae
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aromatase Inhibitors); 0 (Plant Extracts); 2DI9HA706A (Estrone); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human); V27W9254FZ (Cortisone)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:160512
[Lr] Data última revisão:
160512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140408
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-014-7764-1


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[PMID]:24594240
[Au] Autor:Vieira SM; Silva RL; Lemos HP; Amorim RC; Silva EC; Reinach PS; Cunha FQ; Pohlit AM; Cunha TM
[Ad] Endereço:National Institute for Research in the Amazon (INPA), Av Andre Araújo 2936, CEP 69060-001, Manaus, Amazonas State, Brazil; Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av Bandeirantes 3900, CEP 14049-900, Ribeirão Preto, São Paulo State, Brazil.
[Ti] Título:Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei.
[So] Source:Fitoterapia;95:8-15, 2014 Jun.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we determined herein that one of the main constituents found in P. sprucei infusions, the quassinoid isobrucein B (IsoB), reduces some of the pathophysiological effects in a mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced gastritis and provides mechanisms of action. Then, IsoB (1.17 g) was isolated from the roots and stems (6.5 kg) of P. sprucei. Its structure was confirmed by 1D and 2D (1)H and (13)C NMR, ESI-tof-MS, IR and UV. C57BL/6 strain mice were subcutaneously injected with IsoB (0.5-5 mg kg(-1)) or vehicle before oral administration of indomethacin and sacrificed later at different time points. Gastric damage was assessed by measuring lesion length. Leukocyte migration was evaluated based on leukocyte rolling and adhesion using intravital microscopy in the mesenteric microcirculation and tissue MPO activity. Stomach extract cytokine (TNFα, IL-1ß and KC/CXCL1) and prostaglandin E2 (PGE2) levels were measured by ELISA and RIA, respectively. IsoB pre-treatment (0.5-5.0 mg kg(-1)) significantly reduced the formation of indomethacin-induced stomach lesions in a dose-dependent manner. The decrease in stomach lesions was associated with less observed leukocyte rolling, decreased leukocyte adhesion and less neutrophil infiltration (MPO activity). IsoB (1 mg kg(-1)) pre-treatment did not prevent indomethacin-induced decreases in stomach PGE2 levels. However, IL-1ß and KC/CXCL1 levels were inhibited by this same IsoB dosage, whereas TNF-α was unchanged. IsoB may be a prototypic compound to provide protective effects against NSAID-induced gastritis and possibly other gastropathies. Moreover, IsoB gastroprotective action may be due to a reduction in IL-1ß and KC/CXCL1 production/release and leukocyte rolling, adhesion and migration.
[Mh] Termos MeSH primário: Gastrite/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Quassinas/uso terapêutico
Simaroubaceae/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/efeitos adversos
Anti-Inflamatórios não Esteroides/metabolismo
Adesão Celular/efeitos dos fármacos
Citocinas/metabolismo
Dinoprostona/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mucosa Gástrica/efeitos dos fármacos
Gastrite/induzido quimicamente
Indometacina/metabolismo
Leucócitos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Estrutura Molecular
Neutrófilos/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
Caules de Planta/química
Plantas Medicinais
Quassinas/química
Quassinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Plant Extracts); 0 (Quassins); 53663-03-9 (isobrucein B); K7Q1JQR04M (Dinoprostone); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140507
[Lr] Data última revisão:
140507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140306
[St] Status:MEDLINE


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[PMID]:23901646
[Au] Autor:Yan XX; Liang ZF; Wang MY; Wang JR; Wang ZN
[Ad] Endereço:Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences/Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Ministry of Agriculture, Danzhou 571737, China. yxx6232@163.com
[Ti] Título:[Study on the chemical constituents in the fruit of Harrisonia perforata].
[So] Source:Zhong Yao Cai;36(2):223-5, 2013 Feb.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the chemical constituents in the fruit of Harrisonia perforata. METHODS: The chemical constituents were isolated and purified by means of chromatographic techniques and their structures were elucidated by analysis of spectroscopic data and physicochemical properties. RESULTS: Eight compounds were isolated and identified as caryolane-1,9beta-diol (1), gallic acid (2), 4-O-ethylgallic acid (3), syringic acid ethyl ester (4), protocatechuic acid (5), stigmasterol (6), beta-daucoster (7), beta-sitosterol (8). CONCLUSION: Compounds 1, 3 - 5 and 7 are isolated from this plant for the first time. Compounds 1, 3 and 4 are isolated from this genus for the first time.
[Mh] Termos MeSH primário: Frutas/química
Ácido Gálico/análogos & derivados
Hidroxibenzoatos/química
Simaroubaceae/química
beta Caroteno/química
[Mh] Termos MeSH secundário: Cromatografia em Camada Delgada
Ácido Gálico/química
Ácido Gálico/isolamento & purificação
Hidroxibenzoatos/isolamento & purificação
Estrutura Molecular
beta Caroteno/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydroxybenzoates); 01YAE03M7J (beta Carotene); 0XW32QVU6J (3,5-dihydroxy-4-methoxybenzoic acid); 36R5QJ8L4B (protocatechuic acid); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130802
[St] Status:MEDLINE


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[PMID]:23893086
[Au] Autor:Muhr J; Angert A; Negrón-Juárez RI; Muñoz WA; Kraemer G; Chambers JQ; Trumbore SE
[Ad] Endereço:Department of Biogeochemical Processes, Max-Planck Institute for Biogeochemistry, Jena 07745, Germany. jmuhr@bgc-jena.mpg.de
[Ti] Título:Carbon dioxide emitted from live stems of tropical trees is several years old.
[So] Source:Tree Physiol;33(7):743-52, 2013 Jul.
[Is] ISSN:1758-4469
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Storage carbon (C) pools are often assumed to contribute to respiration and growth when assimilation is insufficient to meet the current C demand. However, little is known of the age of stored C and the degree to which it supports respiration in general. We used bomb radiocarbon ((14)C) measurements to determine the mean age of carbon in CO2 emitted from and within stems of three tropical tree species in Peru. Carbon pools fixed >1 year previously contributed to stem CO2 efflux in all trees investigated, in both dry and wet seasons. The average age, i.e., the time elapsed since original fixation of CO2 from the atmosphere by the plant to its loss from the stem, ranged from 0 to 6 years. The average age of CO2 sampled 5-cm deep within the stems ranged from 2 to 6 years for two of the three species, while CO2 in the stem of the third tree species was fixed from 14 to >20 years previously. Given the consistency of (14)C values observed for individuals within each species, it is unlikely that decomposition is the source of the older CO2. Our results are in accordance with other studies that have demonstrated the contribution of storage reserves to the construction of stem wood and root respiration in temperate and boreal forests. We postulate the high (14)C values observed in stem CO2 efflux and stem-internal CO2 result from respiration of storage C pools within the tree. The observed age differences between emitted and stem-internal CO2 indicate an age gradient for sources of CO2 within the tree: CO2 produced in the outer region of the stem is younger, originating from more recent assimilates, whereas the CO2 found deeper within the stem is older, fueled by several-year-old C pools. The CO2 emitted at the stem-atmosphere interface represents a mixture of young and old CO2. These observations were independent of season, even during a time of severe regional drought. Therefore, we postulate that the use of storage C for respiration occurs on a regular basis challenging the assumption that storage pools serve as substrates for respiration only during times of limited assimilation.
[Mh] Termos MeSH primário: Dióxido de Carbono/metabolismo
Fabaceae/metabolismo
Simaroubaceae/metabolismo
[Mh] Termos MeSH secundário: Carbono/análise
Carbono/metabolismo
Dióxido de Carbono/análise
Radioisótopos de Carbono/análise
Peru
Caules de Planta/metabolismo
Chuvas
Estações do Ano
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 142M471B3J (Carbon Dioxide); 7440-44-0 (Carbon)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:130812
[Lr] Data última revisão:
130812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130730
[St] Status:MEDLINE
[do] DOI:10.1093/treephys/tpt049


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[PMID]:23886455
[Au] Autor:Su Z; Hao J; Xu Z; Huang R; Zhang N; Qiu S
[Ad] Endereço:a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , 510650 , People's Republic of China.
[Ti] Título:A new quassinoid from fruits of Brucea javanica.
[So] Source:Nat Prod Res;27(21):2016-21, 2013.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new minor quassinoid named bruceine M (1), together with 12 known quassinoids (2-13), was isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were determined by interpretation of NMR and HR-ESI-MS data. The structures of the known compounds were confirmed by comparison of their spectral data with those reported in the literatures. In vitro cytotoxicity of the isolated compounds against cancer cell lines Bel-7404, MCF-7 and A549 was evaluated. Compounds 4, 6 and 9 exhibited significant growth inhibitory activity against three cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos/química
Brucea/química
Frutas/química
Quassinas/química
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Estrutura Molecular
Quassinas/farmacologia
Simaroubaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Quassins)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131119
[Lr] Data última revisão:
131119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130727
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2013.821119



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