Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.898.044 [Categoria DeCS]
Referências encontradas : 83 [refinar]
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[PMID]:29225138
[Au] Autor:Jeong M; Kim HM; Ahn JH; Lee KT; Jang DS; Choi JH
[Ad] Endereço:Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, South Korea.
[Ti] Título:9-Hydroxycanthin-6-one isolated from stem bark of Ailanthus altissima induces ovarian cancer cell apoptosis and inhibits the activation of tumor-associated macrophages.
[So] Source:Chem Biol Interact;280:99-108, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The stem bark of Ailanthus altissima is used in traditional medicine in Asia to treat a variety of diseases, including cancer. The aim of this study was to identify compounds with tumoricidal activity from A. altissima stem bark and to investigate their mechanisms of action. Among the 13 compounds isolated from the ethyl acetate fraction of A. altissima stem bark, the ß-carboline alkaloid 9-hydroxycanthin-6-one had potent cytotoxicity in all three ovarian cancer cell types examined. 9-Hydroxycanthin-6-one induced apoptosis through the activation of caspases-3, -8, and -9. 9-Hydroxycanthin-6-one increased the intracellular levels of reactive oxygen species (ROS), and pre-treatment with the antioxidant N-acetyl-l-cysteine (NAC) attenuated the pro-apoptotic activity of 9-hydroxycanthin-6-one. Additionally, 9-hydroxycanthin-6-one was found to decrease the expressions of MCP-1 and RANTES, major determinants of macrophage recruitment at tumor sites, in ovarian cancer cells. Treatment with 9-hydroxycanthin-6-one inhibited the levels of M2 phenotype markers and some cancer-promoting factors, such as MMP-2, MMP-9, and VEGF, in macrophages educated in ovarian cancer conditioned medium. Taken together, these data suggest that 9-hydroxycanthin-6-one isolated from A. altissima stem bark induces apoptosis in human ovarian cancer cells through the caspase- and ROS-dependent pathways and inhibits the activation of tumor-associated macrophages.
[Mh] Termos MeSH primário: Ailanthus/química
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Alcaloides de Indol/farmacologia
Macrófagos/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/farmacologia
Ailanthus/metabolismo
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/farmacologia
Inibidores de Caspase/farmacologia
Caspases/química
Caspases/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Quimiocinas/genética
Quimiocinas/metabolismo
Feminino
Seres Humanos
Alcaloides de Indol/química
Alcaloides de Indol/isolamento & purificação
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Oligopeptídeos/farmacologia
Neoplasias Ovarianas/metabolismo
Neoplasias Ovarianas/patologia
Casca de Planta/química
Casca de Planta/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (9-hydroxycanthin-6-one); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Caspase Inhibitors); 0 (Chemokines); 0 (Indole Alkaloids); 0 (Oligopeptides); 0 (Reactive Oxygen Species); 0 (Vascular Endothelial Growth Factor A); 0 (benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone); EC 3.4.22.- (Caspases); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28334171
[Au] Autor:Aigner BL; Kuhar TP; Herbert DA; Brewster CC; Hogue JW; Aigner JD
[Ad] Endereço:Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0319 (baigner@vt.edu; tkuhar@vt.edu; herbert@vt.edu; carlyleb@vt.edu; hogue@vt.edu; daigner@vt.edu).
[Ti] Título:Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) Infestations in Tree Borders and Subsequent Patterns of Abundance in Soybean Fields.
[So] Source:J Econ Entomol;110(2):487-490, 2017 Apr 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The invasive brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an important pest of soybean (Glycine max L. Merr.) in the Mid-Atlantic United States. In order to assess the influence of nonmanaged wooded borders on H. halys infestation patterns in soybean, 12 soybean fields in Orange and Madison Counties, VA, were sampled each week from July to October in 2013 or 2014 for H. halys. At each location, five 2-min visual counts of H. halys life stages were made on tree of heaven (Ailanthus altissima Mill.) and other favorable host trees along a wooded border, on the adjacent soybean edge, 15 m into the soybean field, and 30 m into the field. Seasonal data showed a clear trend at all locations of H. halys densities building up on A. altissima-dominated wooded borders in July, then, gradually moving into adjacent soybean field edges later in the summer. Halyomorpha halys did not move far from the invading field edge, with approximately half as many bugs being present at 15 m into the field and very few being detected 30 m into the field. These results have implications for continued monitoring and management using field border sprays, particularly on edges adjacent to woods.
[Mh] Termos MeSH primário: Heterópteros/fisiologia
Feijão de Soja
Árvores
[Mh] Termos MeSH secundário: Ailanthus
Animais
Proteção de Cultivos/métodos
Espécies Introduzidas
Dinâmica Populacional
Estações do Ano
Virginia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox047


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[PMID]:28069731
[Au] Autor:Liu H; Mottern J
[Ad] Endereço:Pennsylvania Department of Conservation and Natural Resources, Harrisburg, PA 17105 hliu@pa.gov.
[Ti] Título:An Old Remedy for a New Problem? Identification of Ooencyrtus kuvanae (Hymenoptera: Encyrtidae), an Egg Parasitoid of Lycorma delicatula (Hemiptera: Fulgoridae) in North America.
[So] Source:J Insect Sci;17(1), 2017 Jan.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spotted Lanternfly, Lycorma delicatula (White) is a recently introduced pest of Tree-of-Heaven, Ailanthus altissima (Mill.) Swingle in North America. Natural enemy surveys for this pest in Pennsylvania in 2016 recovered an encyrtid egg parasitoid from both field collections and laboratory rearing of field-collected L. delicatula egg masses. Both molecular and morphological data confirm that the egg parasitoids are Ooencyrtus kuvanae (Howard) (Hymenoptera: Encyrtidae). Ooencyrtus kuvanae (Howard) is primarily an egg parasitoid of gypsy moth, Lymantria dispar (L.), and was introduced to North America in 1908 for gypsy moth biological control. Although O. kuvanae is known to attack multiple host species, to our knowledge, this is the first report of O. kuvanae as a primary parasitoid of a non-lepidopteran host. Potential of O. kuvanae in the biological control of L. delicatula in North America and research needs are discussed.
[Mh] Termos MeSH primário: Hemípteros/parasitologia
Himenópteros/fisiologia
Controle Biológico de Vetores
[Mh] Termos MeSH secundário: Ailanthus/crescimento & desenvolvimento
Animais
Complexo IV da Cadeia de Transporte de Elétrons/genética
Hemípteros/crescimento & desenvolvimento
Himenópteros/anatomia & histologia
Himenópteros/genética
Proteínas de Insetos/genética
Óvulo/parasitologia
Pennsylvania
RNA Ribossômico 28S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Proteins); 0 (RNA, Ribosomal, 28S); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:27890583
[Au] Autor:Thongnest S; Boonsombat J; Prawat H; Mahidol C; Ruchirawat S
[Ad] Endereço:Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand. Electronic address: sanit@cri.or.th.
[Ti] Título:Ailanthusins A-G and nor-lupane triterpenoids from Ailanthus triphysa.
[So] Source:Phytochemistry;134:98-105, 2017 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bioactivity-guided chemical investigation of the CH Cl and CH Cl MeOH extracts of the stem and stem bark material of Ailanthus tryphysa (Simaroubaceae) led to the isolation of five cycloapotirucallanes, ailanthusins A-E, two malabaricanes, ailanthusins F-G, and one nor-lupane triterpenoid, 29-nor-lup-1-ene-3,20-dione along with twenty known compounds. Their structures were elucidated through the application of extensive spectroscopic methods, and the structure of ailanthusin A was further confirmed by single crystal X-ray analysis. Several malabaricane derivatives were prepared from malabaricol and, together with some of the isolates, were evaluated for their cytotoxic activities against human cancer and normal cell lines.
[Mh] Termos MeSH primário: Ailanthus/química
Antineoplásicos Fitogênicos/isolamento & purificação
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Células Hep G2
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Casca de Planta/química
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Triterpenes); 0 (ailanthusin A); 464-99-3 (lupane)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE


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[PMID]:28480373
[Au] Autor:Gong X
[Ad] Endereço:VIP Internal Medicine, No.1 Donggang West Road, Chengguan District, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
[Ti] Título:PROTECTIVE EFFECT OF ROXB IN MYOCARDIAL INFARCTION POST MESENCHYMAL STEM CELL TRANSPLANTATION: STUDY IN CHRONIC ISCHEMIC RAT MODEL.
[So] Source:Afr J Tradit Complement Altern Med;13(6):155-162, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Thia study evaluates the effects of Roxb methanolic extract (AER-ME) in rats induced with Myocardial Infarction (MI) followed by transplantation of MSCs. MATERIAL AND METHODS: Rats were induced with MI by ligation technique of left coronary artery. The sham-operated the control and AER-ME treated group of rats received transplantation of PKH-26 and marked MSCs followed by normal saline and AER-ME treatment (200mg/kg/day of AER-ME extract) respectively for 30 days. Parameters such as cardiac function, inflammation, oxidative stress, apoptosis and differentiation of MSCs (angiogenesis) were evaluated. Histological studies of infracted myocardium reveled anti-inflammatory activity of AER-ME treatment. RESULT AND DISCUSSION: Oxidative stress parameters revealed decrease in levels of malondialdehyde (MDA) and increase in superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHpx) activity significantly indicating antioxidant activity of the extract. There was a reduction in cell death rate of treated rats due to the decrease in apoptotic index with prolongation of MI when compared to both control and sham-operated groups. The expression of Fas protein was parallel to apoptotic index. The vascular density increased significantly in extract treated group. The treatment showed improved cardiac activity with decreased left ventricular end diastolic (LVEDP) and arterial pressure while the left ventricular end systolic pressure (LVEP) and dp/dtmax increased significantly when compared to both control and sham-operated groups respectively showing the protective effect of the extract as necessitated by the transplantation of MSCs. The study marked the protective outcomes of AER-ME treatment for MSCs in microenvironment of infracted myocardium by improving their viability and increasing differentiation into cardiomyocytes.
[Mh] Termos MeSH primário: Ailanthus/química
Metanol/farmacologia
Infarto do Miocárdio/tratamento farmacológico
Fitoterapia/métodos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Modelos Animais de Doenças
Coração/efeitos dos fármacos
Masculino
Transplante de Células-Tronco Mesenquimais/efeitos adversos
Infarto do Miocárdio/etiologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/etiologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.22


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[PMID]:27749263
[Au] Autor:Cudic V; Stojiljkovic D; Jovovic A
[Ti] Título:Phytoremediation potential of wild plants growing on soil contaminated with heavy metals.
[So] Source:Arh Hig Rada Toksikol;67(3):229-239, 2016 Sep 01.
[Is] ISSN:1848-6312
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Phytoremediation is an emerging technology that employs higher plants to cleanup contaminated environments, including metal-polluted soils. Because it produces a biomass rich in extracted toxic metals, further treatment of this biomass is necessary. The aim of our study was to assess the five-year potential of the following native wild plants to produce biomass and remove heavy metals from a polluted site: poplar (Populus ssp.), ailanthus (Ailanthus glandulosa L.), false acacia (Robinia pseudoacacia L.), ragweed (Artemisia artemisiifolia L.), and mullein (Verbascum thapsus L). Average soil contamination with Pb, Cd, Zn, Cu, Ni, Cr, and As in the root zone was 22,948.6 mg kg-1, 865.4 mg kg-1, 85,301.7 mg kg-1, 3,193.3 mg kg-1, 50.7 mg kg-1, 41.7 mg kg-1,and 617.9 mg kg-1, respectively. We measured moisture and ash content, concentrations of Pb, Cd, Zn, Cu, Ni, Cr, and As in the above-ground parts of the plants and in ash produced by combustion of the plants, plus gross calorific values. The plants' phytoextraction and phytostabilisation potential was evaluated based on their bioconcentration factor (BCF) and translocation factor (TF). Mullein was identified as a hyperaccumulator for Cd. It also showed a higher gross calorific value (19,735 kJ kg-1) than ragweed (16,469 kJ kg-1).The results of this study suggest that mullein has a great potential for phytoextraction and for biomass generation, and that ragweed could be an effective tool of phytostabilisation.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Intoxicação por Metais Pesados
Metais Pesados/metabolismo
Raízes de Plantas/metabolismo
Envenenamento/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Ailanthus/metabolismo
Artemisia
Monitoramento Ambiental
Populus/metabolismo
Robinia/metabolismo
Sérvia
Verbascum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil Pollutants)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


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[PMID]:27529695
[Au] Autor:Cabra-Rivas I; Castro-Díez P
[Ad] Endereço:Departamento de Ciencias de la Vida, Unidad Docente de Ecología, Facultad de Biología, Ciencias Ambientales y Química, Universidad de Alcalá, N-II, Km 33.6, PO Box 20, Alcalá de Henares (28805), Madrid, Spain.
[Ti] Título:Comparing the Sexual Reproductive Success of Two Exotic Trees Invading Spanish Riparian Forests vs. a Native Reference.
[So] Source:PLoS One;11(8):e0160831, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A widely accepted hypothesis in invasion ecology is that invasive species have higher survival through the early stages of establishment than do non-invasive species. In this study we explore the hypothesis that the sexual reproductive success of the invasive trees Ailanthus altissima (Mill.) Swingle and Robinia pseudoacacia L. is higher than that of the native Fraxinus angustifolia Vahl., all three species coexisting within the riparian forests of Central Spain. We compared different stages of the early life cycle, namely seed rain, seed infestation by insects, seed removal by local fauna, seed germination under optimal conditions and seedling abundance between the two invasive trees and the native, in order to assess their sexual reproductive success. The exotic species did not differ from the native reference (all three species displaying high seed rain and undergoing seed losses up to 50% due to seed removal by the local fauna). Even if the exotic R. pseudoacacia showed a high percentage of empty and insect-parasited seeds along with a low seedling emergence and the exotic A. altissima was the species with more viable seeds and of higher germinability, no differences were found regarding these variables when comparing them with the native F. angustifolia. Unsuitable conditions might have hampered either seedling emergence and survival, as seedling abundance in the field was lower than expected in all species -especially in R. pseudoacacia-. Our results rather suggest that the sexual reproductive success was not higher in the exotic trees than in the native reference, but studies focusing on long-term recruitment would help to shed light on this issue.
[Mh] Termos MeSH primário: Ailanthus/fisiologia
Florestas
Espécies Introduzidas
Árvores/fisiologia
[Mh] Termos MeSH secundário: Ailanthus/crescimento & desenvolvimento
Germinação
Regeneração
Reprodução
Plântulas/fisiologia
Sementes/crescimento & desenvolvimento
Sementes/fisiologia
Árvores/crescimento & desenvolvimento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160831


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[PMID]:27196883
[Au] Autor:Kim HM; Lee JS; Sezirahiga J; Kwon J; Jeong M; Lee D; Choi JH; Jang DS
[Ad] Endereço:College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. hyemi586@gmail.com.
[Ti] Título:A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle.
[So] Source:Molecules;21(5), 2016 May 16.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present investigation of the chemical constituents of the stem barks of Ailanthus altissima has resulted in the isolation of six canthinone-type alkaloids, including a new compound, (R)-5-(1-hydroxyethyl)-canthine-6-one (1), and five known compounds (2-6). Moreover, four phenyl propanoids (7-10), two lignans (11 and 12), two triterpenoids (13 and 14) and a fatty acid (15) having previously known chemical structures were isolated during the same course of this study. The structure of the new compound was elucidated by physical (m.p., [α]D) and spectroscopic data (¹H-NMR, (13)C-NMR, 2D NMR, and HR-DART-MS) interpretation and its absolute configuration was determined by electronic circular dichroism (ECD) data and quantum chemical calculations. The inflammatory activities of the isolates were screened on lipopolysaccharide (LPS)-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. Among these isolated compounds, six compounds exhibited significant inhibition of NO production, with IC50 values in the range of 5.92 ± 0.9 to 15.09 ± 1.8 µM.
[Mh] Termos MeSH primário: Ailanthus/química
Alcaloides/química
Inflamação/tratamento farmacológico
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Alcaloides/administração & dosagem
Alcaloides/isolamento & purificação
Animais
Inflamação/induzido quimicamente
Lignanas/química
Espectroscopia de Ressonância Magnética
Camundongos
Casca de Planta/química
Propanóis/química
Células RAW 264.7/efeitos dos fármacos
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Lignans); 0 (Plant Extracts); 0 (Propanols); 0 (Triterpenes); 0F897O3O4M (1-phenylpropanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE


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[PMID]:27146531
[Au] Autor:Ranieri E; Fratino U; Petrella A; Torretta V; Rada EC
[Ad] Endereço:Polytechnic University of Bari, DICATECh, 70125, Bari, Italy. ezio.ranieri@poliba.it.
[Ti] Título:Ailanthus Altissima and Phragmites Australis for chromium removal from a contaminated soil.
[So] Source:Environ Sci Pollut Res Int;23(16):15983-9, 2016 Aug.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The comparative effectiveness for hexavalent chromium removal from irrigation water, using two selected plant species (Phragmites australis and Ailanthus altissima) planted in soil contaminated with hexavalent chromium, has been studied in the present work. Total chromium removal from water was ranging from 55 % (Phragmites) to 61 % (Ailanthus). After 360 days, the contaminated soil dropped from 70 (initial) to 36 and 41 mg Cr/kg (dry soil), for Phragmites and Ailanthus, respectively. Phragmites accumulated the highest amount of chromium in the roots (1910 mg Cr/kg(dry tissue)), compared with 358 mg Cr/kg(dry tissue) for Ailanthus roots. Most of chromium was found in trivalent form in all plant tissues. Ailanthus had the lowest affinity for Cr(VI) reduction in the root tissues. Phragmites indicated the highest chromium translocation potential, from roots to stems. Both plant species showed good potentialities to be used in phytoremediation installations for chromium removal.
[Mh] Termos MeSH primário: Ailanthus/metabolismo
Biodegradação Ambiental
Cromo/metabolismo
Poaceae/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Cromo/análise
Raízes de Plantas/química
Plantas
Solo
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6804-0


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[PMID]:26956770
[Au] Autor:Wang R; Xu Q; Liu L; Liang X; Cheng L; Zhang M; Shi Q
[Ad] Endereço:a Department of Medicinal Natural Product Chemistry , School of Pharmaceutical Sciences, Hebei Medical University , Shijiazhuang Hebei Province , China ;
[Ti] Título:Antitumour activity of 2-dihydroailanthone from the bark of Ailanthus altissima against U251.
[So] Source:Pharm Biol;54(9):1641-8, 2016 Sep.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Context The bark of Ailanthus altissima (Mill.) Swingle (Simaroubaceae) is traditionally used to treat ascariasis, diarrhoea, spermatorrhoea, bleeding and gastrointestinal diseases. Objective The objective of this study is to investigate the antitumour activity and mechanism of 2-dihydroailanthone isolated from A. altissima. Materials and methods The U251 cells were treated with 1.00, 4.00 and 8.00 µg/mL of 2-dihydroailanthone for 48 h and the normal cells treated with 20.00 µg/mL of 2-dihydroailanthone were tested as well. Proliferation inhibition of 2-dihydroailanthone on the cells was tested by MTT. Apoptosis and cell-cycle distribution in U251 cells with 1.00, 3.00 and 5.80 µg/mL of 2-dihydroailanthone for 48 h were determined by flow cytometry, respectively. The expression of the apoptosis-related genes and proteins was analysed by RT-PCR and Western blot method, respectively. Results MTT assay revealed that 2-dihydroailanthone inhibited U251 cells proliferation. The cell viability of U251 cells was 62.82, 31.34 and 25.58%, and that of three normal cells was 72.75, 82.74 and 44.92%, respectively. Flow cytometry assay showed that 2-dihydroailanthone induced apoptosis and G0/G1 phase cycle arrest towards U251 cells. The late apoptotic cells were 11.37, 21.73 and 33.83%, and the cells cycle distributed in the G0/G1 accounted for 48.85, 62.77 and 64.40%, respectively. The Western blot and RT-PCR assay showed that up-regulation of pro-apoptotic bax protein and down-regulation of anti-apoptotic bcl-2 protein as well as their mRNA on U251 cells might be related to the apoptosis induction and proliferation inhibition. Conclusion An important bioactive component, 2-dihydroailanthone, has antitumour effects, enlightening a novel source of phytomedicines in tumour therapy.
[Mh] Termos MeSH primário: Ailanthus
Antineoplásicos Fitogênicos/farmacologia
Neoplasias Encefálicas/tratamento farmacológico
Glioma/tratamento farmacológico
Casca de Planta
Extratos Vegetais/farmacologia
Quassinas/farmacologia
[Mh] Termos MeSH secundário: Ailanthus/química
Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Neoplasias Encefálicas/genética
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Regulação Neoplásica da Expressão Gênica
Glioma/genética
Glioma/metabolismo
Glioma/patologia
Células HEK293
Seres Humanos
Células PC12
Fitoterapia
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Quassinas/isolamento & purificação
Ratos
Proteína X Associada a bcl-2/genética
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-dihydroailanthone); 0 (Antineoplastic Agents, Phytogenic); 0 (BAX protein, human); 0 (BCL2 protein, human); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Quassins); 0 (bcl-2-Associated X Protein)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1110827



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