Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.898.111 [Categoria DeCS]
Referências encontradas : 94 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 10 ir para página                        

  1 / 94 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28455552
[Au] Autor:Chumkaew P; Pechwang J; Srisawat T
[Ad] Endereço:Faculty of Science and Industrial Technology, Prince of Songkla University, Suratthani Campus, Suratthani, 84000, Thailand. parinuch.c@gmail.com.
[Ti] Título:Two new antimalarial quassinoid derivatives from the stems of Brucea javanica.
[So] Source:J Nat Med;71(3):570-573, 2017 Jul.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3-8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC values of 1.41 and 1.06 µM, respectively.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Brucea/química
Malária/parasitologia
Extratos Vegetais/farmacologia
Plasmodium falciparum/efeitos dos fármacos
Quassinas/farmacologia
[Mh] Termos MeSH secundário: Antimaláricos/química
Antimaláricos/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
Caules de Planta/química
Plasmodium falciparum/crescimento & desenvolvimento
Quassinas/química
Quassinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 0 (Quassins); 0 (brujavanol C); 0 (brujavanol D)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-017-1089-2


  2 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28731697
[Au] Autor:Scarpi D; Faggi C; Occhiato EG
[Ad] Endereço:Dipartimento di Chimica "U. Schiff", Università degli Studi di Firenze , Via della Lastruccia 13, 50019, Sesto Fiorentino (FI), Italy.
[Ti] Título:Total Synthesis of Bruceolline I.
[So] Source:J Nat Prod;80(8):2384-2388, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first total synthesis of the natural product bruceolline I, isolated in small quantities from the ethanol extract of Brucea mollis stems, was achieved in 29% yield over nine steps and with high enantiomeric purity (>98%). The key step of the process is the tandem gold-catalyzed rearrangement/Nazarov reaction of a propargylic acetate derivative. This synthesis provides a sufficient amount of synthesized bruceolline I for further bioassays.
[Mh] Termos MeSH primário: Brucea/química
Ciclopentanos/síntese química
Indóis/síntese química
Caules de Planta/química
[Mh] Termos MeSH secundário: Produtos Biológicos
Catálise
Ciclopentanos/química
Ciclopentanos/isolamento & purificação
Indóis/química
Indóis/isolamento & purificação
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Cyclopentanes); 0 (Indoles); 0 (bruceolline I)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00311


  3 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28587214
[Au] Autor:Wu Z; Li L; Li N; Zhang T; Pu Y; Zhang X; Zhang Y; Wang B
[Ad] Endereço:Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New District, Shanghai 201203, China. m18700957985@163.com.
[Ti] Título:Optimization of Ultrasonic-assisted Extraction of Fatty Acids in Seeds of Brucea Javanica (L.) Merr. from Different Sources and Simultaneous Analysis Using High-Performance Liquid Chromatography with Charged Aerosol Detection.
[So] Source:Molecules;22(6), 2017 Jun 04.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Our research aimed to optimize the oil extraction process and determine the fatty acids in (L.) Merr. seeds. The extraction technology was optimized using response surface methodology. A Box-Behnken design was employed to investigate the effects of three independent variables on an ultrasonic-assisted extraction technique, namely, sonication time (X1: 20-40 min), liquid-solid ratio (X2: 16:1 mL/g-24:1 mL/g), and ethanol concentration (X3: 90%-100%). The optimum conditions of sonication time, liquid-solid ratio, and ethanol concentration were 40 min, 24:1 mL/g, and 100%, respectively. The content of fatty acids and the oil yield were 14.64 mg/g and 16.87%, respectively, which match well with the predicted models. The optimum number of extraction times was eventually identified as two. A new rapid method for the qualitative and quantitative analysis of the fatty acids of (L.) Merr. seed oil using HPLC with a charged aerosol detector was described. The fatty acid contents of 14 batches of (L.) Merr. seed oil were determined, and the relevance and difference were analyzed by fingerprint analysis. The fingerprint has five common peaks, and the similarity was greater than 0.991. HPLC analysis represents a specialized and rational approach for the quality identification and comprehensive evaluation of (L.) Merr. seed oils.
[Mh] Termos MeSH primário: Brucea/química
Ácidos Graxos/análise
Óleos Vegetais/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Ácidos Graxos/química
Sementes/química
Sonicação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Plant Oils)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  4 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28407533
[Au] Autor:Guo N; Zhang X; Bu F; Wang L; Cao Z; Geng C; Guo R; Ren D; Wen Q
[Ad] Endereço:Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan, China.
[Ti] Título:Determination of brusatol in plasma and tissues by LC-MS method and its application to a pharmacokinetic and distribution study in mice.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1053:20-26, 2017 May 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The quassinoid brusatol, which can be isolated from Brucea javanica (L.) Merr., becomes popularly studied because of its anti-tumor activity. In order to further investigate brusatol and extend its applications, a sensitive analytical method for determination of brusatol in biological samples is essential. However, few methods had been reported until now. In this study, a highly sensitive and reproducible LC-MS method for simultaneous quantification of brusatol in mouse plasma and tissues was developed and validated. METHOD: Plasma samples and tissue homogenate were extracted with diethyl ether after addition of the internal standard solution(IS). The supernatant was blown to dryness with nitrogen and residual was reconstituted with 100µl of methanol. The separation was performed on an Intersil ODS-3 column and gradient elution was conducted with the mobile phase of water and methanol (0-5min 47:53, 5-5.5min 47:53-10:90, 5.5-9min 10:90, posttime 4min 47:53) at a flow rate of 0.8mL/min. Quantification was performed in the selected ion monitoring (SIM) mode at m/z 543.2 for brusatol and 220.0 for IS (ornidazole). The method was validated by analyzing quality control plasma and tissue homogenate samples, and was applied to analyze samples obtained from mice after injections of brusatol via the tail vein. RESULTS: With ornidazole as the internal standard, calibration curve of the method ranged from 10 to 320ng/ml for plasma and 10-240ng/ml for tissues. Recovery rate of brusatol from plasma and tissues were between 71.09%-94.91%. Relative standard deviation (RSD) for inter- and intra-day precision was less than 15%, and the accuracy was between 96.1%-111.8%. The pharmacokinetics and distribution study of brusatol in mice after three single doses via the tail vein were carried out based on this method. The concentration of brusatol in plasma decreased rapidly and a more than 10 fold concentration of brusatol was found as compared to that in other tissues. CONCLUSIONS: This is the first reported LC-MS method for detecting brusatol in tissues and can accurately determine the concentrations of these compounds in plasma and different tissues. Further research on the metabolism of brusatol in vivo is still needed.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacocinética
Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas/métodos
Quassinas/farmacocinética
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/sangue
Antineoplásicos Fitogênicos/química
Brucea/química
Feminino
Limite de Detecção
Masculino
Camundongos
Quassinas/sangue
Quassinas/química
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Quassins); 14907-98-3 (brusatol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  5 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28285062
[Au] Autor:Zou A; Li Y; Chen Y; Angelova A; Garamus VM; Li N; Drechsler M; Angelov B; Gong Y
[Ad] Endereço:Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address: aihuazou@ecust.
[Ti] Título:Self-assembled stable sponge-type nanocarries for Brucea javanica oil delivery.
[So] Source:Colloids Surf B Biointerfaces;153:310-319, 2017 May 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sponge-type nanocarriers (spongosomes) are produced upon dispersion of a liquid crystalline sponge phase formed by self-assembly of an amphiphilic lipid in excess aqueous phase. The inner organization of the spongosomes is built-up by randomly ordered bicontinuous lipid membranes and their surfaces are stabilized by alginate chains providing stealth properties and colloidal stability. The present study elaborates spongosomes for improved encapsulation of Brucea javanica oil (BJO), a traditional Chinese medicine that may strongly inhibit proliferation and metastasis of various cancers. The inner structural organization and the morphology characteristics of BJO-loaded nanocarriers at varying quantities of BJO were determined by cryogenic transmission electron microscopy (Cryo-TEM), small angle X-ray scattering (SAXS) and dynamic light scattering (DLS). Additionally, the drug loading and drug release profiles for BJO-loaded spongosome systems also were determined. We found that the sponge-type liquid crystalline lipid membrane organization provides encapsulation efficiency rate of BJO as high as 90%. In vitro cytotoxicity and apoptosis study of BJO spongosome nanoparticles with A549 cells demonstrated enhanced anti-tumor efficiency. These results suggest potential clinical applications of the obtained safe spongosome formulations.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/farmacologia
Brucea/química
Portadores de Fármacos/química
Portadores de Fármacos/síntese química
Nanopartículas/química
Óleos/administração & dosagem
Óleos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Óleos/química
Tamanho da Partícula
Relação Estrutura-Atividade
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Drug Carriers); 0 (Oils)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  6 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28166749
[Au] Autor:Ablat A; Halabi MF; Mohamad J; Hasnan MH; Hazni H; Teh SH; Shilpi JA; Mohamed Z; Awang K
[Ad] Endereço:Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats.
[So] Source:BMC Complement Altern Med;17(1):94, 2017 Feb 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate with their pharmacological activities. METHODS: A hydroethanolic extract of B. javanica seeds was fractionated with n-hexane, chloroform and ethyl acetate. An active fraction was selected after screening for its ability to inhibit α-glucosidase and glycogen phosphorylase α (GP-α). Isolation and characterization were carried out by using column chromatography, NMR and LCMS/MS. All isolates were assayed for inhibition of GP-α and α-glucosidase. Antidiabetic effect of active fraction was further evaluated in T2D rat model. Blood glucose and body weight were measured weekly. Serum insulin, lipid profile, renal function, liver glycogen and biomarkers of oxidative stress and inflammation were analyzed after 4-week treatment and compared with standard drug glibenclamide. RESULTS: Ethyl acetate fraction (EAF) exerted good inhibitory potential for α-glucosidase and GP-α compared with other fractions. Chromatographic isolation of the EAF led to the identification of seven compounds: vanillic acid (1), bruceine D (2), bruceine E (3), parahydroxybenzoic acid (4), luteolin (5), protocatechuic acid (6), and gallic acid (7). Among them, Compound (5) was identified as the most potent inhibitor of GP-α and α-glucosidase and its GP-α inhibitory activity (IC = 45.08 µM) was 10-fold higher than that of caffeine (IC = 457.34 µM), and α-glucosidase inhibitory activity (IC = 26.41 µM) was 5.5-fold higher than that of acarbose (IC = 145.83 µM), respectively. Compounds (4), (6), and (7) inhibited GP-α activity in a concentration-dependent manner with IC values of 357.88, 297.37, and 214.38 µM, and their inhibitory effect was higher than that of caffeine. These compounds exhibited weak potency on α-glucosidase compared with acarbose. Compounds (1), (2), and (3) showed no inhibition on both GP-α and α-glucosidase. In vivo study showed that EAF treatment significantly reduced blood glucose level, increased insulin and glycogen contents, decreased markers of oxidative stress and inflammation, and lipid levels in T2D rats compared with untreated group. CONCLUSIONS: The EAF has potential therapeutic value for the treatment of T2D via acting as GP-α and α-glucosidase inhibitors by improving hepatic glucose and carbohydrate metabolism, suppressing oxidative stress, and preventing inflammation in T2D rats. According to the results, the efficacy of EAF could be due to the presence of luteolin along with synergistic effect of multiple compounds such as parahydroxybenzoic acid, protocatechuic acid, and gallic acid in B. javanica seeds.
[Mh] Termos MeSH primário: Brucea
Diabetes Mellitus Tipo 2/tratamento farmacológico
Glicoproteínas/efeitos dos fármacos
Hipoglicemiantes/farmacologia
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Teste de Tolerância a Glucose
Hipoglicemiantes/química
Hipoglicemiantes/uso terapêutico
Concentração Inibidora 50
Masculino
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Ratos
Ratos Sprague-Dawley
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoproteins); 0 (Hypoglycemic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1610-x


  7 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28151875
[Au] Autor:Sun Z; Cao Y; Zhai LZ
[Ad] Endereço:aFirst clinical medical college of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong,China bDepartment of Oncology Center, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
[Ti] Título:Java brucea and Chinese herbal medicine for the treatment of cholesterol granuloma in the suprasellar and sellar regions: A case report and literature review.
[So] Source:Medicine (Baltimore);96(5):e5930, 2017 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A cholesterol granuloma (CG) is usually found in the middle ear, papilla, orbits, petrous apex, and choroid plexus, but is highly uncommon in the skull. In spite of benign clinicopathological lesions, bone erosion can be seen occasionally in the patient with CG. The optimal treatment strategy is radical surgery, but complete excision is usually impossible due to anatomical restrictions and a risk of injury to the key structures located nearby. Here, we report a patient with CGs in the suprasellar and sellar regions who was successfully treated with Java brucea and Chinese herbal medicine. PATIENT CONCERNS: A 31-year-old man presenting with progressive decreased vision in both eyes was analyzed. DIAGNOSES: A skull magnetic resonance imaging (MRI) scan showed a low-density tumor in the uprasellar and sellar regions and histopathological examination revealed a CG. INTERVENTIONS: The patient was referred the surgery and radiotherapy. In the meantime, brucea soft capsules and herbal medicine combined were administered to him. OUTCOMES: The related clinical symptoms and signs resolved significantly after several months, as his therapy progressed. The patient showed no sign of recurrence during the treatment period. Furthermore, he was still alive and disease-free at 37 months of follow-up visit. LESSONS: Overall, brucea soft capsules and a Chinese herbal formula treatment combined could be beneficial in improving the patient's quality of life with CG in the skull.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/tratamento farmacológico
Brucea
Medicamentos de Ervas Chinesas/uso terapêutico
Granuloma/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Neoplasias Encefálicas/radioterapia
Medicamentos de Ervas Chinesas/farmacologia
Granuloma/radioterapia
Seres Humanos
Masculino
Qualidade de Vida
Esplenopatias/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005930


  8 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28119098
[Au] Autor:Huang YF; Zhou JT; Qu C; Dou YX; Huang QH; Lin ZX; Xian YF; Xie JH; Xie YL; Lai XP; Su ZR
[Ad] Endereço:Guangdong Provincial Key Laboratory of New Chinese Medicinal Development and Research, College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, People's Republic of China.
[Ti] Título:Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice.
[So] Source:J Ethnopharmacol;198:389-398, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Brucea javanica is an important traditional medicinal herb used for the treatment of dysentery, malaria, inflammation and cancer in southeast Asia for many years. However, the anti-inflammatory mechanism of Brucea javanica in the treatment of dysentery (also known as ulcerative colitis, UC) has not been fully illuminated. Brucea javanica oil emulsion (BJOE) is the major active and most common application form of Brucea javanica oil (BJO), which has a variety of pharmacological activities. The aim of this study was to investigate the potential anti-inflammatory effect of BJOE and possible mechanism of action on dextran sulfate sodium (DSS)-induced UC in mice. MATERIALS AND METHODS: The components of BJOE were determined by gas chromatography-mass spectrometry (GC-MS). Balb/C mice with dextran sulfate sodium (DSS, 30mg/mL) induced colitis were treated with BJOE (0.5, 1 and 2g/kg) and two positive drugs (sulfasalazine, SASP, 200mg/kg; and azathioprine, AZA, 13mg/kg) once daily by gavage for 7 days. Mice in normal control group and DSS group were orally given the same volume of distilled water and soybean lecithin suspension (0.15g/kg) respectively. The effects of BJOE on DSS-induced UC were assessed by determination of body weight loss, disease activity index (DAI), colon length, histological analysis, as well as levels of pro-inflammatory cytokines. The mRNA expression of MPO, iNOS and COX-2 in colon tissues was detected by qRT-PCR. In addition, NF-κB p65, p-p65 and IκB-α, p-IκBα protein expression levels in colon tissues were investigated using Western blotting. RESULTS: The major components of BJOE were found to be oleic acid (62.68%) and linoleic acid (19.53%) as detected by GC-MS. Our results indicated that BJOE, SASP and AZA showed beneficial effect on DSS-induced colitis in mice, and significantly reduced the body weight loss and DAI, restored the colon length, repaired colonic pathological variations, decreased histological scores, and decreased the levels of pro-inflammatory cytokines (TNF-α, IL-1ß, IL-6, IL-8, IL-17 and IFN-γ) as compared with the DSS group. In addition, the mRNA expression of MPO, iNOS and COX-2 induced by DSS treatment was remarkably inhibited by BJOE, SASP or AZA treatments. Furthermore, when compared with DSS-treated mice, the activation of NF-κB was significantly inhibited by AZA and BJOE treatment. CONCLUSIONS: Our study shows that BJOE possessed appreciable anti-inflammatory effect against murine experimental UC induced by DSS. The protective mechanism of BJOE may involve inhibition of NF-κB signal transduction pathways and subsequent down-regulation of inflammatory mediators. These findings suggest that BJOE might be an efficacious and promising therapeutic approach for the treatment of UC. Our investigation might also provide experimental evidence for the traditional application of Brucea javanica in the treatment of dysentery and might add new dimension to the clinical indications for BJOE.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Brucea/química
Colite Ulcerativa/tratamento farmacológico
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Azatioprina/farmacologia
Colite Ulcerativa/patologia
Citocinas/metabolismo
Sulfato de Dextrana
Modelos Animais de Doenças
Emulsões
Cromatografia Gasosa-Espectrometria de Massas
Mediadores da Inflamação/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Transdução de Sinais/efeitos dos fármacos
Sulfassalazina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Emulsions); 0 (Inflammation Mediators); 0 (NF-kappa B); 0 (Plant Oils); 3XC8GUZ6CB (Sulfasalazine); 9042-14-2 (Dextran Sulfate); MRK240IY2L (Azathioprine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


  9 / 94 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27380205
[Au] Autor:Chumkaew P; Srisawat T
[Ad] Endereço:a Faculty of Science and Industrial Technology , Prince of Songkla University , Suratthani Campus, Suratthani 84000 , Thailand.
[Ti] Título:Antimalarial and cytotoxic quassinoids from the roots of Brucea javanica.
[So] Source:J Asian Nat Prod Res;19(3):247-253, 2017 Mar.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new quassinoids, brujavanol A (1) and brujavanol B (2), along with five known quassinoids (3-7), were isolated from the roots of Brucea javanica. Their structures were elucidated by spectroscopic methods. The antimalarial and cytotoxic activities of the isolated compounds were also assessed. Compounds 1 and 2 exhibited significant in vitro cytotoxicity against human oral cavity cancer (KB) cells with IC values of 1.30 and 2.36 µg/ml, respectively, whereas compound 3 showed excellent antiplasmodial activity against the Plasmodium falciparum strains, K1 (IC = 0.58 µg/ml).
[Mh] Termos MeSH primário: Antimaláricos/isolamento & purificação
Antimaláricos/farmacologia
Brucea/química
Raízes de Plantas/química
Plasmodium falciparum/efeitos dos fármacos
Quassinas/isolamento & purificação
Quassinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antimaláricos/química
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Quassinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Quassins); 0 (brujavanol A); 0 (brujavanol B)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1205040


  10 / 94 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27041332
[Au] Autor:Yan Z; Guo GF; Zhang B
[Ad] Endereço:State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.
[Ti] Título:Research of Brucea javanica against cancer.
[So] Source:Chin J Integr Med;23(2):153-160, 2017 Feb.
[Is] ISSN:1672-0415
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Brucea javanica, a Chinese herbal medicine, combined with conventional anticancer modalities, has been widely used for treatment of various cancers. Based on researches over the last decades, authors briefly summarized its active constituents, molecular mechanisms and clinical application for cancer treatment.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Pesquisa Biomédica/tendências
Brucea/química
Medicamentos de Ervas Chinesas/uso terapêutico
Neoplasias/tratamento farmacológico
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Pesquisa Biomédica/métodos
Seres Humanos
Neoplasias/patologia
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1007/s11655-016-2501-6



página 1 de 10 ir para página                        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde