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  1 / 31 MEDLINE  
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[PMID]:28028887
[Au] Autor:Tala MF; Talontsi FM; Zeng GZ; Wabo HK; Spiteller M; Tan NH; Tane P
[Ad] Endereço:Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Phytochemical Analysis of a Cytotoxic Fraction of Quassia silvestris using LC-HR-ESI-MS .
[So] Source:Phytochem Anal;28(3):210-216, 2017 May.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The genus Quassia is a promising source of secondary metabolites with biological potential including antimalarial and cytotoxic activities. Limited data are available on the phytochemistry and pharmacology of Quassia silvestris Cheek & Jongkind, a Cameroonian medicinal plant used to treat various ailments. OBJECTIVES: To carry out the bioassay-guided fractionation and LC-HR-ESI-MS analyses of the leaves extract from Q. silvestris; to purify the active fractions and isolate the major compounds using different chromatographic and spectroscopic methods. The obtained compounds will be evaluated for their biological activity. MATERIAL AND METHODS: Following the cytotoxic screening and LC-HR-ESI-MS profiling of fractions obtained from partition of the methanolic extract of Q. silvestris leaves, the CH Cl -soluble fraction which exhibited the highest cytotoxicity was retained for further investigations. RESULTS: Sixteen squalene-derived metabolites were identified with oxasqualenoid derivatives being the most predominant. Among the isolates, structure elucidation of two new oxasqualenoids quassiols E (1) and F (2), were achieved by NMR (one-dimensional (1D) and two-dimensional (2D)) and MS methods. The newly characterised compounds 1 and 2, together with the known tetraol (3) and 3-oxo-oleanoic acid (16) displayed moderate cytotoxicity. CONCLUSION: The identification and structural characterisation of highly oxidised squalene derived metabolites from this plant may provide important insight data for further pharmacological investigations. The LC-HR-ESI-MS method reported here could be developed as a rapid and efficient tool for the analyses of structurally related compounds in the genera Quassia, Simarouba, and Eurycoma of the subfamily Simarouboideae. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Cromatografia Líquida/métodos
Quassia/química
Espectrometria de Massas por Ionização por Electrospray/métodos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Fracionamento Químico
Furanos/química
Seres Humanos
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/análise
Folhas de Planta/química
Plantas Medicinais/química
Piranos/química
Quassia/classificação
Esqualeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Furans); 0 (Plant Extracts); 0 (Pyrans); 0 (quassiol E); 0 (quassiol F); 7QWM220FJH (Squalene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1002/pca.2663


  2 / 31 MEDLINE  
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[PMID]:27039464
[Au] Autor:Nau JY
[Ti] Título:[FRENCH BIO-PIRATES AND QUASSIA AMARA HERBAL PREPARATION AGAINST MALARIA. ].
[Ti] Título:LES BIOPIRATES FRANÇAIS ET LA TISANE DE QUASSIA AMARA CONTRE LE PALUDISME..
[So] Source:Rev Med Suisse;12(506):370-1, 2016 Feb 17.
[Is] ISSN:1660-9379
[Cp] País de publicação:Switzerland
[La] Idioma:fre
[Mh] Termos MeSH primário: Malária/tratamento farmacológico
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Quassia/química
[Mh] Termos MeSH secundário: Bebidas
Bioética
Conflito de Interesses
França
Guiana Francesa
Medicina Herbária/métodos
Seres Humanos
Medicina Tradicional/métodos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160404
[Lr] Data última revisão:
160404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


  3 / 31 MEDLINE  
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[PMID]:26537647
[Au] Autor:Nishizaki Y; Tada A; Ishizuki K; Ito Y; Onoda A; Sugimoto N; Akiyama H
[Ad] Endereço:National Institute of Health Science.
[Ti] Título:[Development of a Novel Method for Quantifying Quassin and Neoquassin in Jamaica Quassia Extracts Using the Molar Absorption Coefficient Ratio].
[So] Source:Shokuhin Eiseigaku Zasshi;56(5):185-93, 2015.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A novel HPLC-based method employing molar absorption coefficient ratios to 4-hydroxybenzoic acid (4HBA) was developed for the determination of quassin and neoquassin in Jamaica quassia extract, which is used as a food additive in Japan. Based on comparisons of quantitative NMR (qNMR) spectra and HPLC chromatograms of an artificial mixture of quassin, neoquassin, and 4HBA, the molar absorption coefficient ratios of quassin and neoquassin to 4HBA were determined as 0.84 and 0.85, respectively. Quassin and neoquassin were quantified in food additives by qNMR and HPLC based on molar absorption coefficient ratios using 1,4-bis(trimethylsilyl)benzene-d4 and 4HBA as internal standards, respectively. The differences in quantitation values between qNMR and HPLC analyses were below 1.2%. Our proposed novel HPLC-based quantitation method employing the molar absorption coefficient ratios is a reliable tool for determining levels of quassin and neoquassin in food additives and processed foods.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Aditivos Alimentares/química
Extratos Vegetais/química
Quassia/química
Quassinas/análise
[Mh] Termos MeSH secundário: Análise de Alimentos/métodos
Hidroxibenzoatos
Espectroscopia de Ressonância Magnética/métodos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 0 (Hydroxybenzoates); 0 (Plant Extracts); 0 (Quassins); 0 (neoquassin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151105
[Lr] Data última revisão:
151105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151106
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.56.185


  4 / 31 MEDLINE  
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[PMID]:25431121
[Au] Autor:Le HL; Jullian V; Claparols C; Vansteelandt M; Haddad M; Cabou C; Deharo E; Fabre N
[Ad] Endereço:Université de Toulouse, UPS, UMR 152 Pharma-DEV, Université Toulouse 3, Faculté des Sciences Pharmaceutiques, F-31062, Toulouse cedex 09, France; Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-DEV, F-31062, Toulouse cedex 09, France.
[Ti] Título:Development and validation of liquid chromatography combined with tandem mass spectrometry methods for the quantitation of simalikalactone E in extracts of Quassia amara L. and in mouse blood.
[So] Source:Phytochem Anal;26(2):111-8, 2015 Mar-Apr.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Simalikalactone E (SkE) from Quassia amara, has been proved to be a valuable anti-malarial and anti-cancer compound. As SkE is very scarce, methods of quantitation are needed in order to optimise its isolation process and to determine pharmacokinetic data. OBJECTIVE: To validate methods using liquid chromatography coupled to mass spectrometry for the quantitation of SkE in plant extracts and in biological fluids. METHODS: High- and ultrahigh-performance liquid chromatography (UHPLC) coupled to ion trap mass spectrometry (MS) with single ion monitoring detection and to triple quadrupole-linear ion trap tandem mass spectrometry with multiple reaction monitoring detection methods were developed. Validation procedure was realised according to the International Conference on Harmonisation guideline. Methanol extracts of dried Quassia amara leaves, and mouse-blood samples obtained after various routes of administration, were analysed for SkE. RESULTS: Methods were validated and gave similar results regarding the content of SkE expressed per kilogram of dry leaves in the traditional decoction (160 ± 12 mg/kg) and in the methanol extract (93 ± 2 mg/kg). The recovery of the analyte from mouse blood ranged from 80.7 to 119.8%. Simalikalactone E was only detected using UHPLC-MS/MS (0.2 ± 0.03 mg/L) in mouse blood after intravenous injection: none was detected following intraperitoneal or oral gavage administration of SkE. CONCLUSION: The LC-MS methods were used for the quantitation of SkE in plant extracts and in mouse blood. These methods open the way for further protocol optimisation of SkE extraction and the determination of its pharmacokinetic data.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Quassia/química
Quassinas/isolamento & purificação
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
Extratos Vegetais/química
Plantas Medicinais
Quassinas/sangue
Quassinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Quassins); 0 (simalikalactone E)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150219
[Lr] Data última revisão:
150219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141129
[St] Status:MEDLINE
[do] DOI:10.1002/pca.2542


  5 / 31 MEDLINE  
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[PMID]:25392586
[Au] Autor:Sama W; Ajaiyeoba EO; Choudhary MI
[Ad] Endereço:Department of Pharmacy, School of Health Medical Sciences, Catholic University of Cameroon (CATUC), Bamenda, Cameroon.
[Ti] Título:Larvicidal properties of simalikalactone D from Quassia africana (Simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae.
[So] Source:Afr J Tradit Complement Altern Med;11(4):84-8, 2014.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Botanical and microbial insecticides have been increasingly used for the control of mosquito given their efficacy and documented nontoxic effects on non-target organisms. The discovery of new insecticides is imperative because of the development of resistance by the mosquitoes to the readily available insecticides. The aim of this study was therefore to isolate and characterize compounds from a local medicinal plant, Quassia africana Baill and Baill (Simaroubaceae) that were toxic to Anopheles gambiae. MATERIAL AND METHODS: The methanol extracts of the leaves, stem and roots of Quassia africana were tested against fourth instar larvae of An. gambiae. The root extract was partitioned into hexane, chloroform and ethyl acetate and the resulting extracts screened for larvicidal properties. The extracts and the fraction with the highest bioactivity were subjected to repeated column chromatography and isolated compounds evaluated for potential toxicity to An. gambiae larvae. The structure of the active compound was elucidated using spectroscopic techniques. The root extract showed the strongest activity profile (LC50 = 17.58 µg/mL). The chloroform soluble fraction obtained after partitioning the crude extract into solvents based on polarities was the most toxic. Further bio-activity-guided chromatographic separation of the chloroform fraction of the root extract led to the identification and isolation of a simalikalactone D as the larvicidal compound in Q. africana (LC50 = 1.25 µg/mL). RESULTS: Results suggest that Q. africana may serve as a source for vector control agent for malaria. CONCLUSION: Simalikalactone D was identified as the larvicidal compound in Q. africana (LC50 = 1.25 µg/mL).
[Mh] Termos MeSH primário: Anopheles/efeitos dos fármacos
Insetos Vetores/efeitos dos fármacos
Inseticidas/farmacologia
Malária
Extratos Vegetais/farmacologia
Quassia/química
Quassinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Larva/efeitos dos fármacos
Malária/prevenção & controle
Malária/transmissão
Folhas de Planta
Raízes de Plantas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Plant Extracts); 0 (Quassins); 35321-80-3 (simalikalactone D)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141114
[St] Status:MEDLINE


  6 / 31 MEDLINE  
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[PMID]:23711829
[Au] Autor:Nsimba MM; Lami JN; Hayakawa Y; Yamamoto C; Kaji T
[Ad] Endereço:Organization for Frontier Research, Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanazawa-machi, Kanazawa 920-1181, Japan.
[Ti] Título:Decreased thrombin activity by a Congolese herbal medicine used in sickle cell anemia.
[So] Source:J Ethnopharmacol;148(3):895-900, 2013 Jul 30.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Aqueous extracts from Ceiba pentandra (Malvaceae/Bombacoideae) and Quassia africana (Simaroubaceae) are used as crude medicines for the management of sickle cell anemia (SCA) in the Democratic Republic of Congo (DR Congo). Since it is postulated that the pathogenesis of SCA is associated with an increased blood coagulation activity, the present study is conducted to determine the effect of the two extracts on the coagulation by assessing the thrombin activity and the plasma clotting time. MATERIALS AND METHODS: Thrombin activity was measured by chromogenic assay in the presence of the aqueous extracts (10, 100 or 200 µg/ml); and plasma clotting times were measured by activated partial thromboplastin time (APTT) and prothrombin time (PT) in the presence of C. pentandra (10, 100 or 200 µg/ml) and Q. africana (5, 20 or 50 µg/ml). RESULTS: Reduced thrombin activity and prolonged plasma clotting time measured by APTT were observed in the presence of C. pentandra extract only. However, plasma clotting time measured by PT was not modified by the use of the two extracts. CONCLUSIONS: This study suggests that the aqueous extract of C. pentandra may contain active components that reduce the thrombin activity and prolong the plasma clotting time by affecting the coagulation intrinsic pathway.
[Mh] Termos MeSH primário: Coagulação Sanguínea/efeitos dos fármacos
Ceiba
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Anemia Falciforme
República Democrática do Congo
Seres Humanos
Medicina Tradicional Africana
Tempo de Tromboplastina Parcial
Casca de Planta
Raízes de Plantas
Tempo de Protrombina
Quassia
Trombina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); EC 3.4.21.5 (Thrombin)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:130709
[Lr] Data última revisão:
130709
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130529
[St] Status:MEDLINE


  7 / 31 MEDLINE  
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[PMID]:23545914
[Au] Autor:Diehl C; Ferrari A
[Ad] Endereço:Universidad Nacional de Córdoba, Córdoba, Argentina. chdiehl@hotmail.com
[Ti] Título:Efficacy of topical 4% Quassia amara gel in facial seborrheic dermatitis:a randomized, double-blind, comparative study.
[So] Source:J Drugs Dermatol;12(3):312-5, 2013 Mar.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Seborrheic dermatitis (SD) is a chronic mild skin disorder with high prevalence. Various treatment options are available, including topical antifungals and anti-inflammatories. Antifungal and anti-inflammatory properties of Quassia amara have been reported. AIM: To check the efficacy and safety of a topical gel with 4% Quassia amara extract and compare it with topical 2% ketoconazole and 1% topical ciclopiroxolamine in the treatment of facial SD. METHODS: A group of 60 patients displaying facial SD were randomly distributed in 3 groups and given either a topical gel with 4% Quassia amara extract, a topical gel with 2% ketoconazole, or a topical gel with 1% ciclopirox olamine for 4 weeks. Disease severity was assessed at the start and weekly along treatment, as well as 4 weeks after the end of treatment. In each selected area, severity of erythema, scaling, pruritus, and papules were scored from 0 to 3, the sum of these values representing the score of SD on the face. This evaluation was conducted at each visit. The decrease in SD score with all 3 products was compared at each visit. At each stage, overall improvement, safety, and tolerability were also assessed. RESULTS: Of the 60 patients, 54 (90%) completed the study. The 3 therapeutic options resulted to be very effective, with a significant advantage in efficacy for 4% Quassia extract. For the other 2 drugs, the results were in line with those previously published in the literature. CONCLUSION: Topical gel with 4% Quassia extract represents a new, safe, and effective treatment for facial SD.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Dermatite Seborreica/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Quassia/química
[Mh] Termos MeSH secundário: Administração Cutânea
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Antifúngicos/administração & dosagem
Antifúngicos/efeitos adversos
Dermatite Seborreica/patologia
Método Duplo-Cego
Dermatoses Faciais/tratamento farmacológico
Dermatoses Faciais/patologia
Feminino
Géis
Seres Humanos
Cetoconazol/administração & dosagem
Cetoconazol/uso terapêutico
Masculino
Meia-Idade
Extratos Vegetais/administração & dosagem
Extratos Vegetais/efeitos adversos
Piridonas/administração & dosagem
Piridonas/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Gels); 0 (Plant Extracts); 0 (Pyridones); 19W019ZDRJ (ciclopirox); R9400W927I (Ketoconazole)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130403
[St] Status:MEDLINE


  8 / 31 MEDLINE  
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[PMID]:23983328
[Au] Autor:Raji Y; Oloyede GK
[Ad] Endereço:Department of Physiology University of Ibadan Ibadan, Nigeria. yinusaraji@gmail.com
[Ti] Título:Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.
[So] Source:Afr J Tradit Complement Altern Med;9(1):112-9, 2012.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:The effects of Quassia amara extract (Q. amara) and its bioactive principles-quassin and 2-methoxycanthin-6-one on gastric ulceration were studied in albino rats. Q. amara (200-800 mg/kg p.o.; 5-20 mg/kg i.p) and 2-methoxycanthin-6-one (12.5, 25.0 and 50.0 mg/kg p.o; 1, 2 and 4 mg/kg i.p) but not quassin (12.5, 25.0 and 50 mg/kg p.o; 1, 2 and 4 mg/kg i.p) significantly inhibited gastric ulceration induced by indomethacin (40mg/kg). Administration of Q. amara (800 mg/kg p.o and 20 mg/kg i.p) and 2-methoxycanthin-6-one (12.5 mg/kg p.o; 4 mg/kg i.p) caused between 77%-85% cytoprotection against indomethacin (40 mg/kg, i.p) - induced gastric ulceration. Quassin did not cause any significant change in indomethacin-induced gastric ulceration. The inhibition of gastric ulceration produced by Q. amara and 2-methoxycanthin-6 one was accompanied by significant dose-dependent decreases (P< 0.01) in total gastric acidity. To investigate the probable mechanism of action, the individual effects of the extract and its principles alone and in combination with histamine (1 mg/kg) or cimetidine (0.12 mg/kg) on gastric acid secretion in situ were studied. Q. amara (20 mg/kg) and 2-methoxycanthin-6-one (4 mg/kg) but not quassin significantly (P< 0.01) inhibited the basal and histamine-induced gastric acid secretion. Inhibition of gastric acid secretion by Q. amara and 2-methoxycanthin-6-one was accentuated by cimetidine. The results suggest that Q. amara and its bioactive principle, 2-methoxycanthin-6-one possess antiulcer activity probably acting via histamine H2 receptor. This could be a potential source of potent and effective antiulcer agents.
[Mh] Termos MeSH primário: Antiulcerosos/uso terapêutico
Carbolinas/uso terapêutico
Ácido Gástrico/secreção
Fitoterapia
Extratos Vegetais/uso terapêutico
Quassia/química
Úlcera Gástrica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/farmacologia
Carbolinas/farmacologia
Cimetidina/farmacologia
Relação Dose-Resposta a Droga
Histamina/farmacologia
Indometacina
Masculino
Extratos Vegetais/farmacologia
Quassinas/farmacologia
Ratos
Ratos Wistar
Úlcera Gástrica/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-methoxycanthin-6-one); 0 (Anti-Ulcer Agents); 0 (Carbolines); 0 (Plant Extracts); 0 (Quassins); 80061L1WGD (Cimetidine); 820484N8I3 (Histamine); QP1YAK6QGK (quassin); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130829
[St] Status:MEDLINE


  9 / 31 MEDLINE  
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[PMID]:22374406
[Au] Autor:Bertani S; Houël E; Jullian V; Bourdy G; Valentin A; Stien D; Deharo E
[Ad] Endereço:USM0307, Laboratoire de Parasitologie Comparée et Modèles Expérimentaux, Muséum National d'Histoire Naturelle (MNHN), Paris, France.
[Ti] Título:New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae).
[So] Source:Exp Parasitol;130(4):341-7, 2012 Apr.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown to be one of the molecules responsible for the antiplasmodial activity of a watery preparation made out of juvenile fresh leaves of this plant. Because of its strong antimalarial activity, we decided to have a further insight of SkD pharmacological properties, alone or in association with classical antimalarials. At concentrations of up to 200µM, we showed herein that SkD did not exert any apoptotic or necrotic activities in vitro on lymphoblastic cells. However, an antiproliferative effect was evident at concentrations higher than 45nM. SkD was inefficient at inhibiting heme biomineralization and the new permeability pathways induced by the parasite in the host erythrocyte membrane. With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier and later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites. In vitro combination studies with conventional antimalarial drugs showed that SkD synergizes with atovaquone (ATO). The activity of ATO on the Plasmodium mitochondrial membrane potential was enhanced by SkD, which on its own had a poor effect on this cellular parameter.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Plasmodium falciparum/efeitos dos fármacos
Plasmodium yoelii/efeitos dos fármacos
Quassia/química
Quassinas/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular/efeitos dos fármacos
Permeabilidade da Membrana Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Membrana Eritrocítica/efeitos dos fármacos
Membrana Eritrocítica/metabolismo
Eritrócitos/efeitos dos fármacos
Eritrócitos/parasitologia
Heme/metabolismo
Seres Humanos
Concentração Inibidora 50
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 0 (Quassins); 35321-80-3 (simalikalactone D); 42VZT0U6YR (Heme)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120301
[St] Status:MEDLINE
[do] DOI:10.1016/j.exppara.2012.02.013


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[PMID]:21343346
[Au] Autor:Ferrari A; Diehl C
[Ad] Endereço:Universidad Nacional de Córdoba, Argentina.
[Ti] Título:Evaluation of the efficacy and tolerance of a topical gel with 4% quassia extract in the treatment of rosacea.
[So] Source:J Clin Pharmacol;52(1):84-8, 2012 Jan.
[Is] ISSN:1552-4604
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There are various treatment options available for rosacea, depending on the subtype, but treatment is still generally unsatisfactory. Some studies have reported antiparasitic and anti-inflammatory properties of Quassia amara. AIM: To check the efficacy and safety of a topical gel with 4% Quassia amara extract in the treatment of various grades of rosacea. METHODS: A group of 30 patients with various grades of rosacea (I-IV) were investigated in a single-center, open-label study. They were treated with a topical gel with 4% Quassia amara extract for 6 weeks. Response was evaluated by the flushing, erythema, telangiectasia, papules, and pustules scores. At the end of therapy, overall improvement, safety, and tolerability were assessed. RESULTS: Twenty-seven of 30 patients (90%) completed the study. The treatment resulted to be very effective, and the results achieved were in line with those published with topical metronidazole and azelaic acid. Safety and tolerability were excellent. CONCLUSION: Topical quassia extract could be a new, efficient, and safe weapon in the armamentarium for the management of rosacea.
[Mh] Termos MeSH primário: Extratos Vegetais/uso terapêutico
Quassia
Rosácea/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Géis
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gels); 0 (Plant Extracts)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:140730
[Lr] Data última revisão:
140730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110224
[St] Status:MEDLINE
[do] DOI:10.1177/0091270010391533



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