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  1 / 19 MEDLINE  
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[PMID]:27659082
[Au] Autor:Mathew J; George R; Theruvil R; Padavil TC; Tomy L; Kurian A
[Ad] Endereço:Department of Conservative Dentistry and Endodontics St. Gregorios Dental College, Kothamangalam, Kerala, India.
[Ti] Título:Antibacterial Activity of Leaf Extract of Annona muricata and Simarouba glauca on Enterococcus faecalis.
[So] Source:J Contemp Dent Pract;17(8):650-3, 2016 Aug 01.
[Is] ISSN:1526-3711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:AIM: To determine the antimicrobial effect of water extracts of leaves of Annona muricata and Simarouba glauca on Enterococcus faecalis using agar diffusion method. MATERIALS AND METHODS: Dried leaves of A. muricata and S. glauca were powdered and extracted in a soxhlet apparatus. Enterococcus faecalis was grown overnight in Trypticase soy agar plates. About 10 µl of each extract was placed on agar plates and incubated overnight. The zone of inhibition was measured after 24 hours. About 1% sodium hypochlorite and distilled water were used as positive and negative controls. RESULTS: The leaf extract of A. muricata showed similar effectiveness as that of sodium hypochlorite, whereas the leaf extract of S. glauca showed only a slight reduction in growth of E. faecalis. CONCLUSION: Leaf extract of A. muricata can be developed as an alternative to sodium hypochlorite for root canal irrigants. CLINICAL SIGNIFICANCE: Success of endodontic treatment depends on complete disinfection of the root canals. Root canal irrigants have a major role in complete disinfection of the root canals. Chemical root canal irrigants are more or less toxic to the oral environment. In this study, naturally derived leaf extracts of A. muricata and S. glauca are compared with sodium hypochlorite for its effectiveness against E. faecalis - the most common pathogen found in the root canals.
[Mh] Termos MeSH primário: Annona
Antibacterianos/farmacologia
Enterococcus faecalis/efeitos dos fármacos
Extratos Vegetais/farmacologia
Simarouba
[Mh] Termos MeSH secundário: Seres Humanos
Folhas de Planta
Irrigantes do Canal Radicular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Root Canal Irrigants)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


  2 / 19 MEDLINE  
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[PMID]:26427915
[Au] Autor:Roussel JR; Clair B
[Ad] Endereço:CNRS, UMR Ecologie des Forêts de Guyane (EcoFoG), Campus Agronomique, BP 701, 97387 Kourou, France.
[Ti] Título:Evidence of the late lignification of the G-layer in Simarouba tension wood, to assist understanding how non-G-layer species produce tensile stress.
[So] Source:Tree Physiol;35(12):1366-77, 2015 Dec.
[Is] ISSN:1758-4469
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:To recover verticality after disturbance, angiosperm trees produce 'tension wood' allowing them to bend actively. The driving force of the tension has been shown to take place in the G-layer, a specific unlignified layer of the cell wall observed in most temperate species. However, in tropical rain forests, the G-layer is often absent and the mechanism generating the forces to reorient trees remains unclear. A study was carried out on tilted seedlings, saplings and adult Simarouba amara Aubl. trees-a species known to not produce a G-layer. Microscopic observations were done on sections of normal and tension wood after staining or observed under UV light to assess the presence/absence of lignin. We showed that S. amara produces a cell-wall layer with all of the characteristics typical of G-layers, but that this G-layer can be observed only as a temporary stage of the cell-wall development because it is masked by a late lignification. Being thin and lignified, tension wood fibres cannot be distinguished from normal wood fibres in the mature wood of adult trees. These observations indicate that the mechanism generating the high tensile stress in tension wood is likely to be the same as that in species with a typical G-layer and also in species where the G-layer cannot be observed in mature cells.
[Mh] Termos MeSH primário: Lignina/fisiologia
Simarouba/fisiologia
Estresse Mecânico
Madeira/fisiologia
[Mh] Termos MeSH secundário: Parede Celular/fisiologia
Microscopia Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9005-53-2 (Lignin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151003
[St] Status:MEDLINE
[do] DOI:10.1093/treephys/tpv082


  3 / 19 MEDLINE  
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[PMID]:26025643
[Au] Autor:Karthikayan S; Sankaranarayanan G; Karthikeyan R
[Ad] Endereço:Research Scholar, Department of Mechanical Engineering, Sathyabama University, Rajiv Gandhi Road, Chennai 600119, India. Electronic address: sskksmit@gmail.com.
[Ti] Título:Green technology effect of injection pressure, timing and compression ratio in constant pressure heat addition cycle by an eco-friendly material.
[So] Source:Ecotoxicol Environ Saf;121:63-6, 2015 Nov.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Present energy strategies focus on environmental issues, especially environmental pollution prevention and control by eco-friendly green technologies. This includes, increase in the energy supplies, encouraging cleaner and more efficient energy management, addressing air pollution, greenhouse effect, global warming, and climate change. Biofuels provide the panorama of new fiscal opportunities for people in rural area for meeting their need and also the demand of the local market. Biofuels concern protection of the environment and job creation. Renewable energy sources are self-reliance resources, have the potential in energy management with less emissions of air pollutants. Biofuels are expected to reduce dependability on imported crude oil with connected economic susceptibility, reduce greenhouse gases, other pollutants and invigorate the economy by increasing demand and prices for agricultural products. The use of neat paradise tree oil and induction of eco-friendly material Hydrogen through inlet manifold in a constant pressure heat addition cycle engine (diesel engine) with optimized engine operating parameters such as injection timing, injection pressure and compression ratio. The results shows the heat utilization efficiency for neat vegetable oil is 29% and neat oil with 15% Hydrogen as 33%. The exhaust gas temperature (EGT) for 15% of H2 share as 450°C at full load and the heat release of 80J/deg. crank angle for 15% Hydrogen energy share.
[Mh] Termos MeSH primário: Biocombustíveis/análise
Temperatura Alta
Emissões de Veículos/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Poluição do Ar
Mudança Climática
Efeito Estufa
Hidrogênio
Petróleo
Óleos Vegetais
Sementes/química
Simarouba/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Biofuels); 0 (Petroleum); 0 (Plant Oils); 0 (Vehicle Emissions); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150909
[Lr] Data última revisão:
150909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150531
[St] Status:MEDLINE


  4 / 19 MEDLINE  
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[PMID]:25365298
[Au] Autor:Maranhão HM; Vasconcelos CF; Rolim LA; Neto PJ; Neto Jda C; Filho RC; Fernandes MP; Costa-Silva JH; Araújo AV; Wanderley AG
[Ad] Endereço:Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco, Recife 50740-521, Brazil.
[Ti] Título:Hepatoprotective effect of the aqueous extract of Simarouba amara Aublet (Simaroubaceae) stem bark against carbon tetrachloride (CCl4)-induced hepatic damage in rats.
[So] Source:Molecules;19(11):17735-46, 2014 Oct 31.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of the aqueous extract of S. amara stem bark (SAAE) on CCl4-induced hepatic damage in rats. SAAE was evaluated by high performance liquid chromatography. The animals were divided into six groups (n = 6/group). Groups I (vehicle-corn oil), II (control-CCl4), III, IV, V and VI were pretreated during 10 consecutive days, once a day p.o, with Legalon® 50 mg/kg b.w, SAAE at doses 100, 250 and 500 mg/kg b.w, respectively. The hepatotoxicity was induced on 11th day with 2 mL/kg of 20% CCl4 solution. 24 h after injury, the blood samples were collected and their livers were removed to biochemical and immunohistochemical analyzes. The SAAE decreased the levels of liver markers and lipid peroxidation in all doses and increased the catalase levels at doses 250 and 500 mg/kg. Immunohistochemical results suggested hepatocyte proliferation in all doses. These results may be related to catechins present in SAAE. Thus, SAAE prevented the oxidative damage at the same time that increased regenerative and reparative capacities of the liver.
[Mh] Termos MeSH primário: Tetracloreto de Carbono/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Casca de Planta/química
Extratos Vegetais/farmacologia
Caules de Planta/química
Substâncias Protetoras/farmacologia
Simarouba/química
[Mh] Termos MeSH secundário: Animais
Fígado/efeitos dos fármacos
Masculino
Extratos Vegetais/química
Substâncias Protetoras/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Protective Agents); CL2T97X0V0 (Carbon Tetrachloride)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141104
[St] Status:MEDLINE
[do] DOI:10.3390/molecules191117735


  5 / 19 MEDLINE  
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[PMID]:23319076
[Au] Autor:Carvalho NM; Bacha FB; Santos AC; Carvalho AQ; Faccin TC; Pott A; Lemos RA
[Ad] Endereço:Faculty of Veterinary Medicine and Animal Sciences (FAMEZ), Federal University of Mato Grosso do Sul, Av. Senador Filinto Müller 2443, Campo Grande, MS 79074-460, Brazil. nmarques.carvalho@gmail.com
[Ti] Título:Spontaneous and experimental intoxication of cattle by Simarouba versicolor A. St.-Hill (Simaroubaceae).
[So] Source:Toxicon;64:55-9, 2013 Mar 15.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study describes an outbreak of Simarouba versicolor intoxication in cattle from Mato Grosso do Sul, Brazil, and reproduces it experimentally. Clinical signs of the affected animals were weakness, tremors, hind limbs incoordination, reluctance to move, sternal and lateral recumbency and death. The main necropsy findings, observed in the abomasum and in segments of the small and large intestines, were diffuse redness and mucosal and serosal swelling. Histological examination revealed necrosis of lymphoid tissues and necrotizing enterocolitis. One experiment was carried out using 3 male calves to test the toxicity of a single dose of S. versicolor leaves at 15 g/kg, 5 g/kg and 2.5 g/kg. Clinical signs, necropsy findings and histological examination of calves receiving 15 g/kg and 5 g/kg leaves were similar to those of cattle from the intoxication outbreak. The calf fed 2.5 g/kg leaves developed clinical symptoms of poisoning and recovered naturally. In a second experiment, two male calves received daily administration of S. versicolor leaves at 1.5 g/kg and 2.5 g/kg for 10 days. They developed clinical signs of intoxication within 24 h and recovered eight to nine days after the leaves were administered. These findings suggest that S. versicolor was responsible for the outbreak studied, although this plant does not have cumulative intoxication effects on cattle.
[Mh] Termos MeSH primário: Doenças dos Bovinos/epidemiologia
Surtos de Doenças/veterinária
Enterocolite Necrosante/veterinária
Intoxicação por Plantas/veterinária
Plantas Tóxicas/envenenamento
Simarouba/envenenamento
[Mh] Termos MeSH secundário: Abomaso/efeitos dos fármacos
Abomaso/patologia
Animais
Autopsia
Brasil/epidemiologia
Bovinos
Doenças dos Bovinos/induzido quimicamente
Doenças dos Bovinos/patologia
Doenças dos Bovinos/transmissão
Enterocolite Necrosante/induzido quimicamente
Enterocolite Necrosante/patologia
Enterocolite Necrosante/transmissão
Intestino Grosso/efeitos dos fármacos
Intestino Grosso/patologia
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/patologia
Tecido Linfoide/efeitos dos fármacos
Tecido Linfoide/patologia
Masculino
Necrose/induzido quimicamente
Necrose/patologia
Intoxicação por Plantas/etiologia
Intoxicação por Plantas/mortalidade
Intoxicação por Plantas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1307
[Cu] Atualização por classe:130212
[Lr] Data última revisão:
130212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130116
[St] Status:MEDLINE


  6 / 19 MEDLINE  
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[PMID]:21910841
[Au] Autor:Hardesty BD
[Ad] Endereço:Smithsonian Tropical Research Institute, Balboa, Ancón, Panama. denise.hardesty@csiro.au
[Ti] Título:Effectiveness of seed dispersal by ants in a Neotropical tree.
[So] Source:Integr Zool;6(3):222-6, 2011 Sep.
[Is] ISSN:1749-4877
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Seed dispersal and subsequent recruitment is the template on which forest regeneration takes place. Hence, considering the scale over which ecological processes occur is key for understanding the overall impact of various dispersal agents. To explore leafcutter ant (Atta colombica) dispersal effectiveness in space and time, seed movement and subsequent recruitment of a large-seeded predominately vertebrate-dispersed tree, Simarouba amara (Aubl. Simaroubaceae), was investigated on Barro Colorado Island, Panama. At each of 218 reproductive-sized adults (≥20 cm diameter at breast height), presence or absence of a leafcutter ant colony was noted, with extensive checks for Atta activity taking place at or in close proximity to seed and seedling transects, which extended 4 cardinal directions for 30 m from each reproductive female tree (n= 74). Only at 2 S. amara trees were nests observed, and in these areas a dense S. amara seedling carpet was observed. Although nearby nest and dump sites might increase local S. amara recruitment in the short term, mortality at these sites is complete or nearly so. Hence, the seed dispersal effectiveness by leafcutter ants appears to be ephemeral and likely contributes inconsequentially to the long-term recruitment and distribution patterns of the species. This finding highlights the importance of evaluating disperser effectiveness at ecologically relevant spatiotemporal scales.
[Mh] Termos MeSH primário: Formigas/fisiologia
Dispersão de Sementes
Simarouba/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Alimentar
Panamá
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1502
[Cu] Atualização por classe:110913
[Lr] Data última revisão:
110913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110914
[St] Status:MEDLINE
[do] DOI:10.1111/j.1749-4877.2011.00246.x


  7 / 19 MEDLINE  
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[PMID]:20955699
[Au] Autor:Reynertson KA; Charlson ME; Gudas LJ
[Ad] Endereço:Center for Complementary and Integrative Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
[Ti] Título:Induction of murine embryonic stem cell differentiation by medicinal plant extracts.
[So] Source:Exp Cell Res;317(1):82-93, 2011 Jan 01.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epidemiological evidence indicates that diets high in fruits and vegetables provide a measure of cancer chemoprevention due to phytochemical constituents. Natural products are a rich source of cancer chemotherapy drugs, and primarily target rapidly cycling tumor cells. Increasing evidence indicates that many cancers contain small populations of resistant, stem-like cells that have the capacity to regenerate tumors following chemotherapy and radiation, and have been linked to the initiation of metastases. Our goal is to discover natural product-based clinical or dietary interventions that selectively target cancer stem cells, inducing differentiation. We adapted an alkaline phosphatase (AP) stain to assay plant extracts for the capacity to induce differentiation in embryonic stem (ES) cells. AP is a characteristic marker of undifferentiated ES cells, and this represents a novel approach to screening medicinal plant extracts. Following a survey of approximately 100 fractions obtained from 12 species of ethnomedically utilized plants, we found fractions from 3 species that induced differentiation, decreasing AP and transcript levels of pluripotency markers (Nanog, Oct-4, Rex-1). These fractions affected proliferation of murine ES, and human embryonal, prostate, and breast carcinoma cells in a dose-dependent manner. Several phytochemical constituents were isolated; the antioxidant phytochemicals ellagic acid and gallic acid were shown to affect viability of cultured breast carcinoma cells.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Células-Tronco Embrionárias/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Diferenciação Celular/genética
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Relação Dose-Resposta a Droga
Células-Tronco Embrionárias/metabolismo
Células-Tronco Embrionárias/fisiologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Seres Humanos
Camundongos
Plantas Medicinais/química
Quassia/química
Simarouba/química
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Plant Extracts); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101020
[St] Status:MEDLINE
[do] DOI:10.1016/j.yexcr.2010.10.010


  8 / 19 MEDLINE  
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[PMID]:19501276
[Au] Autor:de Mesquita ML; de Paula JE; Pessoa C; de Moraes MO; Costa-Lotufo LV; Grougnet R; Michel S; Tillequin F; Espindola LS
[Ad] Endereço:Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brazil.
[Ti] Título:Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
[So] Source:J Ethnopharmacol;123(3):439-45, 2009 Jun 25.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The search for new anti-cancer drugs is one of the most prominent research areas of natural products. Numerous active compounds isolated from Brazilian Cerrado plant species have been studied with promising results. AIM OF THE STUDY: To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture. MATERIAL AND METHOD: Maceration of 50 plant species resulted in 412 hexane, dichloromethane, ethanol and hydroalcohol extracts. The cytotoxicity of the extracts was tested against human colon carcinoma (HCT-8), melanoma (MDA-MB-435), and brain (SF-295) tumor cell lines, using the thiazolyl blue test (MTT) assay. Bioassay-guided fractionation was performed for one active extract. RESULTS AND CONCLUSIONS: Twenty-eight of the 412 tested extracts demonstrated a substantial antiproliferative effect, at least 85% inhibition of cell proliferation at 50 microg/mL against one or more cell lines. Those extracts are obtained from different parts of Anacardiaceae, Annonaceae, Apocynaceae, Clusiaceae, Flacourtiaceae, Sapindaceae, Sapotaceae, Simaroubaceae and Zingiberaceae. Complete dose-response curves were generated and IC(50) values were calculated for these active extracts against four cell lines HCT-8, MDA-MB-435, SF-295 and HL-60 (leukemia), and their direct cytotoxic effects were determined. In summary, 14 extracts of 13 species showed toxicity in all tested tumor cell lines, with IC(50) values ranging from 0.1 to 19.1 microg/mL. The strongest cytotoxic activity was found for the hexane extract of Casearia sylvestris var. lingua stem bark, with an IC(50) of 0.1 microg/mL for HCT-8, 0.9 microg/mL for SF-295, 1.2 microg/mL for MDA-MB-435, and 1.3 microg/mL for HL-60, and Simarouba versicolor root bark, with an IC(50) of 0.5 microg/mL for HCT-8, 0.7 microg/mL for SF-295, 1.5 microg/mL for MDA-MB-435, 1.1 microg/mL for HL-60. Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied. Further studies of the active extracts are necessary for chemical characterization of the active compounds and more extensive biological evaluations.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Magnoliopsida/química
Medicina Tradicional
Neoplasias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Brasil
Casearia
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Ecossistema
Glaucarubina/análogos & derivados
Glaucarubina/isolamento & purificação
Glaucarubina/farmacologia
Glaucarubina/uso terapêutico
Seres Humanos
Concentração Inibidora 50
Extratos Vegetais/farmacologia
Estruturas Vegetais
Simarouba
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 1259-86-5 (glaucarubinone); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:0910
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090609
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2009.03.018


  9 / 19 MEDLINE  
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[PMID]:19286447
[Au] Autor:Govindaraju K; Darukeshwara J; Srivastava AK
[Ad] Endereço:Department of Protein Chemistry and Technology, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570 020, India.
[Ti] Título:Studies on protein characteristics and toxic constituents of Simarouba glauca oilseed meal.
[So] Source:Food Chem Toxicol;47(6):1327-32, 2009 Jun.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In order to exploit the protein rich (47.7 g/100g) simarouba meal in food/feed, studies were conducted on its chemical composition with emphasis on protein characteristics and toxic constituents. Simarouba meal contained high calcium (143 mg/100g) and sodium (79 mg/100g). Saponins with triterpenoid aglycone (3.7 g/100g), alkaloids (1.01 g/100g), phenolics (0.95 g/100g) and phytic acid (0.73 g/100g) were the major toxic constituents identified in simarouba meal. TLC and HPLC results indicated that among different fractions of simarouba saponins, one dominant fraction accounted for about 28%. Proteins of simarouba recorded high in vitro digestibility (88%). SDS-PAGE revealed four major protein bands in molecular weight ranges of 20-24, 36-45 and 55-66 kDa. Apart from, glutamic acid (23.43 g/100g protein) and arginine (10.75 g/100g protein), simarouba protein contained high essential amino acids like leucine (7.76 g/100g protein), lysine (5.62 g/100g protein) and valine (6.12 g/100g protein). Among nutritional indices, simarouba meal recorded a good EAA Index (75.02), C-PER (1.90) and PDCAAS (1.0-Adult group).
[Mh] Termos MeSH primário: Óleos Vegetais/química
Óleos Vegetais/toxicidade
Proteínas de Plantas/química
Proteínas de Plantas/toxicidade
Simarouba/química
Simarouba/toxicidade
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/toxicidade
Aminoácidos/análise
Eletroforese em Gel de Poliacrilamida
Hemaglutininas/química
Hemólise/efeitos dos fármacos
Seres Humanos
Técnicas In Vitro
Minerais/análise
Nitrogênio/química
Fenóis/química
Fenóis/toxicidade
Ácido Fítico/química
Ácido Fítico/toxicidade
Saponinas/química
Saponinas/toxicidade
Sementes/química
Solubilidade
Inibidores da Tripsina/química
Inibidores da Tripsina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amino Acids); 0 (Hemagglutinins); 0 (Minerals); 0 (Phenols); 0 (Plant Oils); 0 (Plant Proteins); 0 (Saponins); 0 (Trypsin Inhibitors); 7IGF0S7R8I (Phytic Acid); N762921K75 (Nitrogen)
[Em] Mês de entrada:0907
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090317
[St] Status:MEDLINE
[do] DOI:10.1016/j.fct.2009.03.006


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Texto completo SciELO Brasil
[PMID]:18949336
[Au] Autor:Valdés AF; Martínez JM; Lizama RS; Vermeersch M; Cos P; Maes L
[Ad] Endereço:Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Marianao, La Habana, Cuba. ayme@ipk.sld.cu
[Ti] Título:In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L.
[So] Source:Mem Inst Oswaldo Cruz;103(6):615-8, 2008 Sep.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:In the present study, an extensive in vitro antimicrobial profiling was performed for three medicinal plants grown in Cuba, namely Simarouba glauca, Melaleuca leucadendron and Artemisia absinthium. Ethanol extracts were tested for their antiprotozoal potential against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum and Plasmodium falciparum. Antifungal activities were evaluated against Microsporum canis and Candida albicans whereas Escherichia coli and Staphylococcus aureus were used as test organisms for antibacterial activity. Cytotoxicity was assessed against human MRC-5 cells. Only M. leucadendron extract showed selective activity against microorganisms tested. Although S. glauca exhibited strong activity against all protozoa, it must be considered non-specific. The value of integrated evaluation of extracts with particular reference to selectivity is discussed.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Artemisia absinthium/química
Melaleuca/química
Extratos Vegetais/farmacologia
Simarouba/química
[Mh] Termos MeSH secundário: Animais
Células Cultivadas/efeitos dos fármacos
Cuba
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:081024
[Lr] Data última revisão:
081024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081025
[St] Status:MEDLINE



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