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Pesquisa : B01.650.940.800.575.912.250.910 [Categoria DeCS]
Referências encontradas : 131 [refinar]
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  1 / 131 MEDLINE  
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[PMID]:27684288
[Au] Autor:Huang SZ; Kong FD; Ma QY; Guo ZK; Zhou LM; Wang Q; Dai HF; Zhao YX
[Ad] Endereço:Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101, People's Republic of China.
[Ti] Título:Nematicidal Stemona Alkaloids from Stemona parviflora.
[So] Source:J Nat Prod;79(10):2599-2605, 2016 Oct 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eight new alkaloids, 3ß-n-butylstemonamine (1), 8-oxo-3ß-n-butylstemonamine (2), 3-n-butylneostemonine (3), 10-epi-3-n-butylneostemonine (4), 8-oxo-oxymaistemonine (5) protostemonine N -oxide (6), (19S)-hydroxy-21-methoxystemofoline (7), and parvistemonine A (8), were isolated from the roots of Stemona parviflora, together with 17 known alkaloids. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1-4 were determined by the ECD exciton chirality method and quantum ECD calculations. Protostemonine (10) and stemofoline (12) showed strong nematicidal activity against Panagrellus redivevus, with IC values of 0.10 and 0.46 µM, respectively.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Antinematódeos/isolamento & purificação
Antinematódeos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Stemonaceae/química
[Mh] Termos MeSH secundário: Alcaloides/química
Antinematódeos/química
Medicamentos de Ervas Chinesas/química
Compostos Heterocíclicos de 4 ou mais Anéis
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antinematodal Agents); 0 (Drugs, Chinese Herbal); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (methoxystemofoline); 29881-57-0 (stemofoline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  2 / 131 MEDLINE  
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[PMID]:27179627
[Au] Autor:Wu Y; Ou L; Han D; Tong Y; Zhang M; Xu X; Zhang C
[Ad] Endereço:State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639# Longmian Road, Nanjing 211198, PR China.
[Ti] Título:Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa.
[So] Source:Fitoterapia;112:22-9, 2016 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neotuberostemonine is a potent antitussive alkaloid extracted from Stemona tuberosa. However, the pharmacokinetics, tissue distribution and excretion of pure neotuberostemonine have not been reported. The present study was aimed to investigate the pharmacokinetic parameters of neotuberostemonine by developing an ultra-high performance liquid chromatography-tandem mass spectrometry method. Neotuberostemonine and tetrahydropalmatine (internal standard, IS) in bio-samples were extracted by protein precipitation with methanol and successfully separated on a Zorbax Extend C18 column by using a mobile phase of acetonitrile and a mixture of 0.1% formic acid and 5mM ammonium acetate. The detection was performed by using positive ion electrospray ionization in multiple reaction monitoring mode. The MS/MS ion transitions were monitored at m/z 376.1→302.0 for neotuberostemonine and 355.8→192.0 for IS. After oral administration of neotuberostemonine in rats, the Cmax and AUC0-∞ were 11.37ng/mL and 17.68ng·h/mL at 20mg/kg and 137.6ng/mL and 167.4ng·h/mL at 40mg/kg, and the t1/2 were 2.28 and 3.04h at 20 and 40mg/kg, respectively. The high neotuberostemonine concentrations were found in intestine, stomach and liver, and there was no long-term accumulation of neotuberostemonine in tissues. Total recoveries of neotuberostemonine were only 0.90% (0.19% in bile, 0.05% in urine and 0.66% in feces), which might be resulted from the intestine and liver first-pass effects, indicating that neotuberostemonine may be mainly excreted as its metabolites. All above results would provide helpful information for the further pharmacological and clinical studies of neotuberostemonine and the crude drug.
[Mh] Termos MeSH primário: Alcaloides/farmacocinética
Lactonas/farmacocinética
Stemonaceae/química
[Mh] Termos MeSH secundário: Animais
Bile/química
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/farmacocinética
Fezes/química
Intestinos/química
Fígado/química
Masculino
Ratos
Ratos Sprague-Dawley
Estômago/química
Espectrometria de Massas em Tandem
Distribuição Tecidual
Urina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Lactones); 0 (neotuberostemonine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE


  3 / 131 MEDLINE  
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[PMID]:27144994
[Au] Autor:Xiang J; Cheng S; Feng T; Wu Y; Xie W; Zhang M; Xu X; Zhang C
[Ad] Endereço:State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing 211198, China.
[Ti] Título:Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.
[So] Source:Int Immunopharmacol;36:158-164, 2016 Jul.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour. This study aimed to investigate the effects of NTS on bleomycin (BLM)-induced pulmonary fibrosis in mice and the underlying mechanism. After BLM administration, NTS were orally administered to mice at 20 and 40mg/kg per day from days 8 to 21, with nintedanib as a positive control. The effect of NTS on BLM-induced mice was assessed via histopathological examination by HE and Masson's trichrome staining, TGF-ß1 level and macrophage recruitment by immunohistochemical staining, expression of profibrotic media and M1/M2 polarization by western blot. RAW 264.7 cells were used to evaluate whether NTS (1, 10, 100µM) directly affected macrophages. The results revealed that NTS treatment significantly ameliorated lung histopathological changes and decreased inflammatory cell counts in the bronchoalveolar lavage fluid. The over-expression of collagen, α-SMA and TGF-ß1 was reduced by NTS. Furthermore, NTS markedly lowered the expression of MMP-2 and TIMP-1 while raised the expression of MMP-9. A further analysis showed that NTS was able to decrease the recruitment of macrophages and to inhibit the M2 polarization in mice lung tissues. The experiment in vitro showed that NTS significantly reduced the arginase-1 (marker for M2) expression in a dose-dependent manner but down-regulated the iNOS (marker for M1) expression only at 100µM. In conclusion, our study demonstrated for the first time that NTS has a significant protective effect on BLM-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Lactonas/uso terapêutico
Macrófagos Alveolares/efeitos dos fármacos
Fibrose Pulmonar/tratamento farmacológico
Stemonaceae/imunologia
[Mh] Termos MeSH secundário: Animais
Bleomicina
Movimento Celular/efeitos dos fármacos
Células Cultivadas
Seres Humanos
Imunossupressão
Ativação de Macrófagos/efeitos dos fármacos
Macrófagos Alveolares/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fibrose Pulmonar/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Lactones); 0 (neotuberostemonine); 11056-06-7 (Bleomycin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170805
[Lr] Data última revisão:
170805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160505
[St] Status:MEDLINE


  4 / 131 MEDLINE  
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[PMID]:26902410
[Au] Autor:Jung KH; Kil YS; Jung J; Park S; Shin D; Lee K; Seo EK; Bae H
[Ad] Endereço:Department of Physiology, College of Korean Medicine, Kyung Hee University, #1 Hoekidong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea.
[Ti] Título:Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.
[So] Source:Phytomedicine;23(1):79-86, 2016 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Our previous study demonstrated that a Stemona tuberosa extract had significant effects on cigarette smoking (CS)-induced lung inflammation in mice. The present study evaluated the potential of tuberostemonine N (T.N) to prevent airway inflammation and suppress airway responses in a CS-induced in vivo COPD model. METHODS: T.N was isolated from the root of ST and analyzed using 1D and 2D NMR. The purity of T.N was accessed using HPLC-ELSD analysis. C57BL/6 mice in this study were whole-body exposed to mainstream CS or room air for 4 weeks, and T.N (1, 5 and 10 mg/kg body wt.) was administered to mice via intraperitoneal (i.p.) injection before CS exposure. The number of inflammatory cells, including neutrophils, macrophages and lymphocytes, and the amount of proinflammatory cytokines and chemokines were accessed from bronchoalveolar lavage fluid (BALF) to investigate the anti-inflammatory effects of T.N. Average alveoli size was also measured using histological analyses. RESULTS: Cellular profiles and histopathological analyses revealed that the infiltration of peribronchial and perivascular inflammatory cells decreased significantly in the T.N-treated groups compared to the CS-exposed control group. T.N significantly inhibited the secretion of proinflammatory cytokines and chemokines in BALF and decreased alveoli size in lung tissue. CONCLUSIONS: These data suggest that T.N exerts anti-inflammatory effects against airway inflammation, and T.N may be a novel therapeutic agent for lung diseases, such as COPD.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Pneumonia/tratamento farmacológico
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/química
Quimiocinas/química
Citocinas/química
Feminino
Pulmão/patologia
Linfócitos/citologia
Macrófagos/citologia
Camundongos
Camundongos Endogâmicos C57BL
Neutrófilos/citologia
Raízes de Plantas/química
Pneumonia/induzido quimicamente
Pneumonia/patologia
Stemonaceae/química
Tabaco/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Chemokines); 0 (Cytokines); 0 (Smoke); 6879-01-2 (tuberostemonine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160223
[Lr] Data última revisão:
160223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160224
[St] Status:MEDLINE


  5 / 131 MEDLINE  
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[PMID]:26190165
[Au] Autor:Han L; Ma YM; An L; Zhang Q; Wang CL; Zhao QC
[Ad] Endereço:a Department of Pharmacy , General Hospital of Shenyang Military Area Command , Shenyang 110840 , China.
[Ti] Título:Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells.
[So] Source:Nat Prod Res;30(10):1186-9, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from Stemona sessilifolia significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from S. sessilifolia plays an important role in reversing MDR of cancer as a P-gp modulator in vitro and may be effective in the treatment of multidrug-resistant cancers.
[Mh] Termos MeSH primário: Resistência a Múltiplos Medicamentos/efeitos dos fármacos
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Stemonaceae/química
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Antineoplásicos/farmacologia
Doxorrubicina/farmacologia
Seres Humanos
Células MCF-7
Paclitaxel/farmacologia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABCB1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (Antineoplastic Agents); 0 (Plant Extracts); 80168379AG (Doxorubicin); P88XT4IS4D (Paclitaxel)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150721
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1045507


  6 / 131 MEDLINE  
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[PMID]:26882674
[Au] Autor:Yi M; xia X; Wu HY; Tian HY; Huang C; But PP; Shaw PC; Jiang RW
[Ti] Título:Structures and Chemotaxonomic Significance of Stemona Alkaloids from Stemona japonica.
[So] Source:Nat Prod Commun;10(12):2097-9, 2015 Dec.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A pair of new alkaloid stereo-isomers, stemocochinin (1) and isostemocochinin (2), was obtained from the roots of Stemona japonica Miq., along with seven known alkaloids, stemonamine (3), isostemonamine (4), maistemonine (5), isomaistemonine (6), croomine (7), stemonine (8), and protostemonine (9). The complete structure and stereochemistry of the pair of isomers were established by extensive analysis of the spectral data. Furthermore, our results indicated that S. japonica is chemically closer to S. sessilifolia than S. tuberosa, which are consistent with our previous DNA study on Stemona species.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides/classificação
Stemonaceae/química
[Mh] Termos MeSH secundário: Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160217
[Lr] Data última revisão:
160217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE


  7 / 131 MEDLINE  
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[PMID]:26376282
[Au] Autor:Ideue E; Shimokawa J; Fukuyama T
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
[Ti] Título:Synthesis of the Common Core Structure of the Stemofoline Alkaloids.
[So] Source:Org Lett;17(20):4964-7, 2015 Oct 16.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel synthetic route to the common core structural motif of the stemofoline alkaloids has been developed. The key transformations include (1) an intramolecular 1,3-dipolar cycloaddition reaction of a highly functionalized nitrone, (2) the subsequent formation of a caged structure via lithiated allylic sulfoxide, and (3) the concomitant sila-Pummerer reaction of α-silylalkenyl sulfoxide to prepare a thioester precursor. A series of stereochemistries on the highly caged core structure characteristic of the stemofoline alkaloids was successfully assembled.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Compostos Heterocíclicos de 4 ou mais Anéis/síntese química
Stemonaceae/química
[Mh] Termos MeSH secundário: Alcaloides/química
Reação de Cicloadição
Compostos Heterocíclicos de 4 ou mais Anéis/química
Estrutura Molecular
Óxidos de Nitrogênio/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Nitrogen Oxides); 0 (nitrones); 29881-57-0 (stemofoline)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150917
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.5b02373


  8 / 131 MEDLINE  
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[PMID]:26197559
[Au] Autor:Liu XY; Wang FP
[Ti] Título:Recent Advances in the Synthesis of Stemona Alkaloids.
[So] Source:Nat Prod Commun;10(6):1093-102, 2015 Jun.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stemona alkaloids, featuring polycyclic structures and interesting bioactivities, constitute a distinct class from the Stemonaceae family. In this review, recent advances in the synthesis of these unique alkaloids are briefly discussed, highlighting the application of novel synthetic strategies to access the core structures, as well as creative solutions to the installation of multiple stereogenic centers. The literature reviewed in this article covers the publications from 2010 to November 2014, a period that witnessed the prosperity of the synthesis of Stemona alkaloids.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Medicamentos de Ervas Chinesas/síntese química
Stemonaceae/química
[Mh] Termos MeSH secundário: Alcaloides/química
Medicamentos de Ervas Chinesas/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150722
[Lr] Data última revisão:
150722
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150723
[St] Status:MEDLINE


  9 / 131 MEDLINE  
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[PMID]:25854758
[Au] Autor:Kil YS; Park J; Han AR; Woo HA; Seo EK
[Ad] Endereço:College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea. k_yunseo@naver.com.
[Ti] Título:A new 9,10-dihydrophenanthrene and cell proliferative 3,4-δ-dehydrotocopherols from Stemona tuberosa.
[So] Source:Molecules;20(4):5965-74, 2015 Apr 03.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A new compound, 9,10-dihydro-5-methoxy-8-methyl-2,7-phenanthrenediol (1), was isolated from the roots of Stemona tuberosa Lour. (Stemonaceae) together with two new optically active compounds, (2S,4'R,8'R)-3,4-δ-dehydrotocopherol (2) and (2R,4'R,8'R)-3,4-δ-dehydrotocopherol (3). The structures of compounds 1-3 were determined on the basis of spectroscopic data analysis. Compounds 2 and 3 were each purified from a stereoisomeric mixture of 2 and 3 by preparative HPLC using a chiral column for the first time. The absolute configurations at C-2 of 2 and 3 were determined by Circular Dichroism (CD) experiments. As a part of the research to find natural wound healing agents, all isolates and the mixture of 2 and 3 were evaluated for their cell proliferative effects using a mouse fibroblast NIH3T3 and a HeLa human cervical cancer cell line. As a result, 1, 2, 3, or the mixture of 2 and 3 showed 41.6%, 78.4%, 118.6%, 38.2% increases of cell proliferation in the mouse fibroblast NIH3T3 respectively, compared to 28.4% increase of δ-tocopherol. Moreover, none of them induced cancer cell proliferation. Therefore, 3,4-δ-dehydrotocopherols, especially pure isomers 2 and 3 can be suggested as potential wound healing agents.
[Mh] Termos MeSH primário: Fenantrenos/química
Fenantrenos/farmacologia
Stemonaceae/química
Tocoferóis/química
Tocoferóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Células HeLa
Seres Humanos
Camundongos
Estrutura Molecular
Células NIH 3T3
Fenantrenos/isolamento & purificação
Raízes de Plantas/química
Tocoferóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phenanthrenes); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150410
[St] Status:MEDLINE
[do] DOI:10.3390/molecules20045965


  10 / 131 MEDLINE  
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[PMID]:25835570
[Au] Autor:Chen G; Jürgens A; Shao L; Liu Y; Sun W; Xia C
[Ad] Endereço:Kunming Botanical Garden, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, Yunnan, China.
[Ti] Título:Semen-Like Floral Scents and Pollination Biology of a Sapromyophilous Plant Stemona japonica (Stemonaceae).
[So] Source:J Chem Ecol;41(3):244-52, 2015 Mar.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:By emitting scent resembling that of organic material suitable for oviposition and/or consumption by flies, sapromyophilous flowers use these flies as pollinators. To date, intensive scent analyses of such flowers have been restricted to Apocynaceae, Annonaceae, and Araceae. Recent studies have suggested that the wide range of volatile organic compounds (VOCs) from sapromyophilous flowers play an important role in attracting saprophagous flies by mimicking different types of decomposing substrates (herbivore and carnivore feces, carrion, and the fruiting bodies of fungi, etc.). In this study, we report the flower visitors and the floral VOCs of Stemona japonica (Blume) Miquel, a species native to China. The flowers do not produce rewards, and pollinators were not observed consuming pollen, thus suggesting a deceptive pollination system. Headspace samples of the floral scent were collected via solid-phase micro-extraction and analysed by gas chromatography coupled with mass spectrometry. Main floral scent compounds were 1-pyrroline (59.2%), 2-methyl-1-butanol (27.2%), and 3-methyl-1-butanol (8.8%), and resulted in a semen-like odor of blooming flowers. The floral constituents of S. japonica were significantly different from those found in previous sapromyophilous plants. An olfaction test indicated that 1-pyrroline is responsible for the semen-like odor in S. japonica flowers. Main flower visitors were shoot flies of the genus Atherigona (Muscidae). Bioassays using a mixture of all identified floral volatiles revealed that the synthetic volatiles can attract Atherigona flies in natural habitats. Our results suggest that the foul-smelling flowers of S. japonica may represent a new type of sapromyophily through scent mimicry.
[Mh] Termos MeSH primário: Flores/metabolismo
Odorantes/análise
Feromônios/química
Feromônios/farmacologia
Polinização/efeitos dos fármacos
Sêmen/química
Stemonaceae/fisiologia
[Mh] Termos MeSH secundário: Animais
Bioensaio
Dípteros/efeitos dos fármacos
Feminino
Masculino
Stemonaceae/metabolismo
Compostos Orgânicos Voláteis/química
Compostos Orgânicos Voláteis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pheromones); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150404
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-015-0563-0



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