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[PMID]:28573243
[Au] Autor:Ndhlovu DN; Masika PJ
[Ad] Endereço:Department of Livestock and Pasture Science, University of Fort Hare, P. Bag X 1314, Alice, 5700 RSA, Faculty of Veterinary Science, University of Zimbabwe, MP 167 Mount Pleasant, Harare, Zimbabwe.
[Ti] Título:IN VITRO EFFICACY OF EXTRACTS FROM PLANTS USED BY SMALL-HOLDER FARMERS IN THE TREATMENT OF DERMATOPHILOSIS IN CATTLE.
[So] Source:Afr J Tradit Complement Altern Med;14(2):263-272, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bovine dermatophilosis, an important skin disease of cattle caused by , negatively impacts the livelihoods of small-holder farmers in Zimbabwe. This impact is through, morbidity, loss of draught animal power, costs incurred to manage the disease, losses associated with devalued damaged hides and the resultant culling of some of the affected cattle. Due to the inaccessibility of conventional drugs to manage bovine dermatophilosis, farmers have been reported to use local medicinal plants to manage the disease. The aim of the study was to evaluate the antimicrobial activities of three plants that small-holder farmers in Zimbabwe used to manage bovine dermatophilosis. METHODS: Dried plant materials were ground into powder and extracted individually using, water, 80 % acetone and 80 % methanol. The antimicrobial properties of the plants were evaluated against two Gram-negative and and one Gram-positive reference bacterial strains. They were further evaluated against a field isolate of . The assays used were the disc diffusion, minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). RESULTS: Acetone and methanol extracts had superior inhibitory activities than did those of water. DC extracts had better inhibitory properties with absolute MIC values of 0.156 - 5 mg/ml, L had MIC values in the range 0.156 - 5 mg/ml while that of Thunb, Terveng was 0.156 - 10 mg/ml. was more sensitive to DC average MIC = 0.63 mg/ml than to L average MIC = 1.25 mg/ml and Thunb, Terveng average MIC = 2.08 mg/ml. CONCLUSION: These results suggest the potential antibacterial activities of extracts of the three plants and hence farmers are, in a way, justified in using the plants. Better results (lower MIC) could be obtained by extracting and evaluating pure active compounds of the plants.
[Mh] Termos MeSH primário: Actinobacteria/efeitos dos fármacos
Doenças dos Bovinos/microbiologia
Cissus
Extratos Vegetais/farmacologia
Pterocarpus
Rubiaceae
Dermatopatias/microbiologia
[Mh] Termos MeSH secundário: Actinobacteria/crescimento & desenvolvimento
Criação de Animais Domésticos
Animais
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Etnobotânica
Extratos Vegetais/uso terapêutico
Plantas Medicinais
Dermatopatias/tratamento farmacológico
Dermatopatias/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.28


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[PMID]:28165166
[Au] Autor:Sawangjit R; Puttarak P; Saokaew S; Chaiyakunapruk N
[Ad] Endereço:Clinical Pharmacy Research Unit (CPRU), Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Kamrieng, Kantarawichai District, Maha Sarakham, 44150, Thailand.
[Ti] Título:Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
[So] Source:Phytother Res;31(4):555-567, 2017 Apr.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cissus quadrangularis L. (Cissus) is a medicinal plant commonly used for centuries for various conditions, but lacks critical appraisal of its clinical effects. This study aimed to determine the efficacy and safety of Cissus in all conditions. Publications from 12 electronic databases were searched from inception through November 2016. A total of nine studies with 1108 patients were included. Each outcome was pooled using a random effects model. Effects of Cissus on hemorrhoid symptoms were not different from any comparators but had significant effects on bone pain. Effects of Cissus combination products on body weight reduction, low-density lipoprotein, triglyceride, total cholesterol, and fasting blood sugar were superior to placebo, with weighted mean difference of -5.19 kg (-8.82, -1.55), -14.43 mg/dl (-20.06, -8.80), -37.50 mg/dl (-48.71, -26.29), -50.50 mg/dl (-70.97, -30.04), and -10.39 mg/dl (-14.60, -6.18), respectively. No serious adverse effects were reported. Quality of evidence based on Grades of Recommendations Assessment Development and Evaluation (GRADE) indicated low (bone fractures) to high quality (hemorrhoids, body weight reduction).In conclusion, Cissus had benefit for bone fractures, but not for hemorrhoids. For obesity/overweight, only combination products are pooled and show benefit. However, high-quality studies remain needed. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Cissus/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5783


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[PMID]:28115176
[Au] Autor:Wellington KW; Leboho T; Sakong BM; Adenubi OT; Eloff JN; Fouche G
[Ad] Endereço:CSIR Biosciences, PO Box 395, Pretoria, South Africa. Electronic address: kwellington@csir.co.za.
[Ti] Título:Further studies on South African plants: Acaricidal activity of organic plant extracts against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
[So] Source:Vet Parasitol;234:10-12, 2017 Jan 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The goal of our research is to develop a lower cost eco-friendly tick control method because acaricides that are commonly used to control ticks are often toxic, harmful to the environment or too expensive for resource-limited farmers. Acetone and ethanol extracts were prepared and their acaricidal activities determined against the southern cattle tick, Rhipicephalus (Boophilus) microplus. A 1% solution of each of the plant extracts was prepared for efficacy testing using the adapted Shaw Larval Immersion Test (SLIT). The acetone stem extract from Cissus quadrangularis (Vitaceae) and the ethanol leaf and flower extract from Calpurnia aurea (Fabaceae) had potent activity like that of the commercial acaricide, chlorfenvinphos [corrected mortality (CM)=100.0%]. The ethanol extracts of the stem of C. quadrangularis (CM=98.9%) and that of the roots, leaves and fruit of Senna italica subsp arachoides (CM=96.7%) also had good acaricidal activity. There is potential for the development of botanicals as natural acaricides against R. (B.) microplus that can be used commercially to protect animals against tick infestation. Further studies to isolate the acaricidal active compounds and to determine the environmental fate, species toxicity and skin toxicity of these plants species are, however, required before they can be considered as a treatment against ticks.
[Mh] Termos MeSH primário: Acaricidas
Cissus/química
Fabaceae/química
Extratos Vegetais/farmacologia
Rhipicephalus/efeitos dos fármacos
Controle de Ácaros e Carrapatos
[Mh] Termos MeSH secundário: Acetona/química
Animais
Clorfenvinfos/farmacologia
Etanol/química
Larva/efeitos dos fármacos
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts); 1364PS73AF (Acetone); 3K9958V90M (Ethanol); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:27264191
[Au] Autor:Tasadduq R; Gordon J; Al-Ghanim KA; Lian JB; Van Wijnen AJ; Stein JL; Stein GS; Shakoori AR
[Ad] Endereço:School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore, Pakistan.
[Ti] Título:Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells.
[So] Source:J Cell Physiol;232(3):540-547, 2017 Mar.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Traditional medicinal literature and previous studies have reported the possible role of Cissus quadrangularis (CQ) as an anti-osteoporotic agent. This study examines the effectiveness of CQ in promoting osteoblast differentiation of the murine pre-osteoblast cell line, MC3T3-E1. Ethanolic extract of CQ (CQ-E) was found to affect growth kinetics of MC3T3-E1 cells in a dosage-dependent manner. High concentrations of CQ-E (more than 10 µg/ml) have particularly adverse effects, while lower concentrations of 0.1 and 1 µg/ml were non-toxic and did not affect cell viability. Notably, cell proliferation was significantly increased at the lower concentrations of CQ-E. CQ-E treatment also augmented osteoblast differentiation, as reflected by a substantial increase in expression of the early osteoblast marker ALP activity, and at later stage, by mineralization of extracellular matrix compared to the control group. These findings suggest dose-dependent effect of CQ-E with lower concentrations exhibiting anabolic and osteogenic properties. J. Cell. Physiol. 232: 540-547, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Calcificação Fisiológica/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Cissus/química
Etanol/farmacologia
Osteoblastos/citologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Calcificação Fisiológica/genética
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Cinética
Camundongos
Osteoblastos/efeitos dos fármacos
Osteoblastos/enzimologia
Osteoblastos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3K9958V90M (Ethanol); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25449


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[PMID]:27647420
[Au] Autor:Adams NF; Collinson ME; Smith SY; Bamford MK; Forest F; Malakasi P; Marone F; Sykes D
[Ad] Endereço:Department of Earth Sciences, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK Department of Geography, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK Neil.Adams.2012@live.rhul.ac.uk.
[Ti] Título:X-rays and virtual taphonomy resolve the first Cissus (Vitaceae) macrofossils from Africa as early-diverging members of the genus.
[So] Source:Am J Bot;103(9):1657-77, 2016 09.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Fossilized seeds similar to Cissus (Vitaceae) have been recognized from the Miocene of Kenya, though some were previously assigned to the Menispermaceae. We undertook a comparative survey of extant African Cissus seeds to identify the fossils and consider their implications for the evolution and biogeography of Cissus and for African early Miocene paleoenvironments. METHODS: Micro-computed tomography (µCT) and synchrotron-based X-ray tomographic microscopy (SRXTM) were used to study seed morphology and anatomy. Virtual taphonomy, using SRXTM data sets, produced digital fossils to elucidate seed taphonomy. Phylogenetic relationships within Cissus were reconstructed using existing and newly produced DNA sequences for African species. Paleobiology and paleoecology were inferred from African nearest living relatives. KEY RESULTS: The fossils were assigned to four new Cissus species, related to four modern clades. The fossil plants were interpreted as climbers inhabiting a mosaic of riverine woodland and forest to more open habitats. Virtual taphonomy explained how complex mineral infill processes concealed key seed features, causing the previous taxonomic misidentification. Newly sampled African species, with seeds most similar to the fossils, belong to four clades within core Cissus, two of which are early diverging. CONCLUSIONS: Virtual taphonomy, combined with X-ray imaging, has enabled recognition of the first fossil Cissus and Vitaceae from Africa. Early-divergent members of the core Cissus clade were present in Africa by at least the early Miocene, with an African origin suggested for the Cissus sciaphila clade. The fossils provide supporting evidence for mosaic paleoenvironments inhabited by early Miocene hominoids.
[Mh] Termos MeSH primário: Evolução Biológica
Cissus/anatomia & histologia
Cissus/classificação
Fósseis/anatomia & histologia
[Mh] Termos MeSH secundário: Quênia
Filogenia
Sementes/anatomia & histologia
Sementes/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600177


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[PMID]:27374242
[Au] Autor:Li YJ; Xu CT; Lin DD; Qin JK; Ye GJ; Deng QH
[Ad] Endereço:Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
[Ti] Título:Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
[So] Source:Bioorg Med Chem Lett;26(15):3425-8, 2016 08 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1-8) in LPS-stimulated murine macrophage RAW 264.7 cells were also investigated. Our results revealed that compound 1 inhibited the production of pro-inflammatory mediators NO and PGE2 and the expression of NF-κB, TNF-α, IL-1ß, iNOS and COX-2.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Cissus/química
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/isolamento & purificação
Relação Dose-Resposta a Droga
Lipopolissacarídeos/antagonistas & inibidores
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Estrutura Molecular
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Caules de Planta/química
Polifenóis/química
Polifenóis/isolamento & purificação
Células RAW 264.7
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lipopolysaccharides); 0 (Polyphenols); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE


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[PMID]:27261621
[Au] Autor:Muthusami S; Gopalakrishnan V; Stanley JA; Krishnamoorthy S; Ilangovan R; Gopalakrishnan VK; Srinivasan N
[Ad] Endereço:Department of Biochemistry, Karpagam University, Eachanari, Coimbatore, Tamilnadu 641021, India; Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani campus, Chennai, 600113, India. Electronic address: sridhar.m@kahedu.edu.in.
[Ti] Título:Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats.
[So] Source:Biomed Pharmacother;81:416-23, 2016 Jul.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. METHODS: Twenty four female adult rats, 90days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n=6) were sham operated and Group-II rats were bilaterally ovariectomized (n=18) and treated with C. quadrangularis for sixty days (100mg/kg body weight and 250mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. RESULTS: Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p<0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats. CONCLUSION: C. quadrangularis, a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.
[Mh] Termos MeSH primário: Cissus/química
Fêmur/efeitos dos fármacos
Fêmur/patologia
Ovariectomia/efeitos adversos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Envelhecimento
Fosfatase Alcalina/metabolismo
Animais
Colágeno/metabolismo
Feminino
Fêmur/enzimologia
Glutationa Peroxidase/metabolismo
Glutationa Transferase/metabolismo
Peróxido de Hidrogênio/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Ratos Wistar
Superóxido Dismutase/metabolismo
Fosfatase Ácida Resistente a Tartarato/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 9007-34-5 (Collagen); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


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[PMID]:26826840
[Au] Autor:Sudmoon R; Chaveerach A; Tanee T
[Ad] Endereço:Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand / Genetics and Environmental Toxicology (GET) Research Group, KhonKaen University, Khon Kaen, Thailand.
[Ti] Título:Analysis of genetics and chemical contents relation compared to commonly used Cissus quadrangularis L. and barcode markers of some Thailand Cissus species.
[So] Source:Pak J Pharm Sci;29(1):65-75, 2016 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Several Cissus species are commonly used as traditional and modified medicines, and their chemical constituents are major point for precise usage. However, C. quadrangularis is the only species for which the usages and the chemical composition have been reported. These data should be investigated for other species in the genus. Eight species namely C. assamica, C. carnosa, C. elongata, C. hastata, C. javana, C. pteroclada, C. quadrangular is and C. repens were evaluated for genetic relationships and chemical composition. Constructed dendrogram shows high-powered efficiency of inter-simple sequence repeat (ISSR) data used which can clearly identify different and identical species. Genetic similarity (S) value of the identical species is 0.86, whereas for different species the value can vary from 0.53 to 0.75. Four highly related species (S=0.64-0.72), C. assamica, C. carnosa, C. hastata and C. repens were selected to undergo chemical study by gas chromatography-mass spectrometry (GC-MS) on the methanol crude extract. Only one compound, ß-sitosterol, found in the four species is identical to the compound reported from C. quadrangular is, where there were five identical chemicals found in the selected species. Species-specific barcode with rbcL region was constructed. Nucleotide variation was evaluated indicating genetic distance value of 0.025 to 0.072.
[Mh] Termos MeSH primário: Cissus/química
Cissus/genética
Código de Barras de DNA Taxonômico
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Extratos Vegetais/análise
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160201
[St] Status:MEDLINE


  9 / 92 MEDLINE  
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Vilegas, Wagner
PubMed Central Texto completo
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[PMID]:26805827
[Au] Autor:Beserra FP; Santos Rde C; Périco LL; Rodrigues VP; Kiguti LR; Saldanha LL; Pupo AS; da Rocha LR; Dokkedal AL; Vilegas W; Hiruma-Lima CA
[Ad] Endereço:Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista-UNESP, CEP 18618-970 Botucatu, São Paulo, Brazil. fbeserra@ibb.unesp.br.
[Ti] Título:Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.
[So] Source:Int J Mol Sci;17(2), 2016 Jan 23.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Antidiarreicos/administração & dosagem
Cissus/química
Edema/tratamento farmacológico
Intestinos/patologia
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Antidiarreicos/química
Antidiarreicos/farmacologia
Dinoprostona/metabolismo
Modelos Animais de Doenças
Edema/induzido quimicamente
Edema/metabolismo
Intestinos/efeitos dos fármacos
Masculino
Camundongos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Xilenos/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antidiarrheals); 0 (Plant Extracts); 0 (Xylenes); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


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[PMID]:26723000
[Au] Autor:Marquis G; Ramasamy B; Banwarilal S; Munusamy AP
[Ad] Endereço:Department of Microbiology, Periyar University, Salem 636011, India. Electronic address: gowdhamimarq@gmail.com.
[Ti] Título:Evaluation of antibacterial activity of plant mediated CaO nanoparticles using Cissus quadrangularis extract.
[So] Source:J Photochem Photobiol B;155:28-33, 2016 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:An assessment of antibacterial activity of greenly synthesized nanoparticles using aqueous stem extract of Cissus quadrangularis was carried out. The synthesized nanoparticles were characterized by UV-Vis spectroscopy, SEM, XRD, FTIR and further subjected for antibacterial activity against the pathogens Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysenteriae and Vibrio cholerae. The SEM photograph represents cubic and hexagonal shape of NPs about 58nm respectively whereas the XRD indicated the pure phase of the product and no impurity in peaks of well crystallized products. The FTIR spectrum of nanoparticles showed intensive peaks with blue shift indicating the crystalline and shorten the distance of crystal lattice. The plant mediated CaO nanoparticles showed maximum inhibition on E. coli followed by other strains. In MIC, the plant mediated CaO NPs possess high activity against all the test organisms whereas the CaCl2 and CaO compounds were moderately active. The approach to the synthesis of plant mediated CaO NPs has many advantages as scaled up, economic viability, etc. Application of such ecofriendly nanoparticles in bactericidal, wound healing and other medical applications makes this method potential existing for the large scale synthesis of the inorganic materials.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Compostos de Cálcio/química
Cissus/química
Nanopartículas Metálicas/química
Óxidos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Cissus/metabolismo
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Química Verde
Nanopartículas Metálicas/toxicidade
Nanopartículas Metálicas/ultraestrutura
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Tamanho da Partícula
Caules de Planta/química
Caules de Planta/metabolismo
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Calcium Compounds); 0 (Oxides); 0 (Plant Extracts); C7X2M0VVNH (lime)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160102
[St] Status:MEDLINE



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