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Pesquisa : B01.650.940.800.575.912.250.987 [Categoria DeCS]
Referências encontradas : 59 [refinar]
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[PMID]:28813688
[Au] Autor:Kanwal N; Adhikari A; Hameed A; Hafizur RM; Musharraf SG
[Ad] Endereço:H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
[Ti] Título:Isolation and characterization of non-sulfated and sulfated triterpenoid saponins from Fagonia indica.
[So] Source:Phytochemistry;143:151-159, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven previously undescribed, sulfated triterpenoid glycosides, named nayabin A-G along with a known triterpenoid glycoside were isolated from the whole plant of Fagonia indica. Their structures were elucidated through spectral studies including 1D- ( H and C), 2D-NMR spectroscopy (HSQC, HMBC, COSY and NOESY), and mass spectrometry (ESI-MS/MS). ß-D-Glucopyranosyl 3ß-hydroxy-23-O-ß-D-glucopyranosyloxy-taraxast-20-en-28-oate, a known compound exerts glucose-dependent insulin secretory activity, which seems to exhibit a decreased risk of drug-induced hypoglycemia and may offer distinct advantages as anti-diabetic agent.
[Mh] Termos MeSH primário: Zygophyllaceae/química
[Mh] Termos MeSH secundário: Glicosídeos
Insulina/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Paquistão
Saponinas/química
Espectrometria de Massas em Tandem
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Insulin); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


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[PMID]:28653912
[Au] Autor:Shad AA; Zakirudin -; Bakht J; Jan S
[Ad] Endereço:Department of Agricultural Chemistry, The University of Agriculture Peshawar, KPK Pakistan.
[Ti] Título:Antimicrobial, antioxidant potential and phytochemical screening of Fagonia olivieri.
[So] Source:Pak J Pharm Sci;30(3):697-703, 2017 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present paper investigates antioxidant, antimicrobial and photochemical screening different extracts of Fagonia olivieri. Analysis of the data indicated that the subject plant contained a good amount of flavonoids, tannins, saponins, terpenoids and steroids. Maximum concentrations of phenolic compounds was found in methanol fraction (29.0±6.12 mg GAE/g) while minimum (22.10±6.31mg GAE/g) in methylated spirit fraction. Similarly, ethanol fraction contained higher concentration of flavonoid content (135.4±7.63mg Quercetin/g) followed by methanol fraction (138.4±2.96 mg Quercetin/g). Analysis of the data revealed that maximum antioxidant activity was recorded in mthylated spirit fraction (IC = 10.69±1.66) followed by methanol fraction (IC = 9.10±0.76) while no activity was noted in hexane fraction. The data indicated good antibacterial and antifungal activity against S. typhi, S. aureus, P. aeruginosa and A. flavus.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28122313
[Au] Autor:Rashid U; Khan MR
[Ad] Endereço:Department of Environmental Sciences, GC Women University Sialkot, Sialkot Pakistan. Electronic address: umbreen.rashid@gmail.com.
[Ti] Título:Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat.
[So] Source:Biomed Pharmacother;88:469-479, 2017 Apr.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Gentamicin is used clinically against Gram negative bacteria because of its efficacy. However, it causes renal injuries and failure at clinical dosages on account of induced oxidative stress. Fagonia olivieri is used in kidneys, liver, alimentary canal and cardiovascular disorders in local system of medicine in Pakistan. This study evaluates the protective abilities of methanol extract of F. olivieri (FOM) against the liver and renal injuries induced with gentamicin in rat. Sprague-Dawley male rats were treated with gentamicin (80mg/kg) alone or with silymarin (50mg/kg) as standard antioxidant drug. The other groups of rats were treated with gentamicin along with FOM (200mg/kg, 400mg/kg) or FOM (400mg/kg) alone. Effect of FOM was investigated on body weight, urine and serum biochemical markers, enzymatic antioxidants of renal and liver along with histopathological alterations. FOM was investigated by GC-MS for the presence of bioactive constituents. Treatment of FOM to rats ameliorated the gentamicin induced toxicity and increased the percent increase in body weight while decreased the absolute and relative weight of hepatic and kidneys. Gentamicin increased the level of specific gravity, count of RBCs and WBCs, and urobilinogen in urine; and AST, ALT, ALP, LDH, total bilirubin, total cholesterol, triglycerides and LDL in serum. Level of lipid peroxides in terms of thiobarbituric acid reactive substances (TBARS) and DNA damages increased while the GSH contents and activity level of CAT, SOD, GSH-Px and GR decreased with gentamicin in liver and kidney samples. Co-treatment of FOM, dose dependently, alleviated the injuries induced with gentamicin. Histopathological studies of liver and kidneys supported the protective abilities of FOM. GC-MS analysis indicated the presence of various compounds including hexadecanoic acid, 2-methoxy-4-vinylphenol, benzoic acid and thalicpureine in the FOM. Results of the present investigation suggested the protective potential of FOM against the oxidative injuries of gentamicin that could be attributed by phytochemicals having antioxidant and free radical scavenging abilities.
[Mh] Termos MeSH primário: Gentamicinas/efeitos adversos
Rim/patologia
Fígado/patologia
Extratos Vegetais/farmacologia
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Biomarcadores/sangue
Peso Corporal/efeitos dos fármacos
Dano ao DNA
Cromatografia Gasosa-Espectrometria de Massas
Glutationa/metabolismo
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/enzimologia
Masculino
Metanol
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Ratos Sprague-Dawley
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Gentamicins); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances); GAN16C9B8O (Glutathione); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:27829418
[Au] Autor:Rashid U; Khan MR; Sajid M
[Ad] Endereço:Department of Environmental Sciences, GC Women University Sialkot, Sialkot, Pakistan.
[Ti] Título:Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat.
[So] Source:BMC Complement Altern Med;16(1):449, 2016 Nov 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fagonia olivieri (DC) being used for the treatment of diabetes, cancer, fever and claimed to be effective in many other stress related disorders. In this study we have evaluated the F. olivieri whole methanol extract and its derived fractions for various in vitro and in vivo antioxidant studies. METHODS: The crude methanol extract of the whole plant of F. olivieri (FOM) and its derived fractions; n-hexane (FOH), chloroform (FOC), ethyl acetate (FOE), n-butanol (FOB) and aqueous (FOA) were evaluated for the total phenolic and flavonoid content and in vitro antioxidant abilities. The antioxidant effect of FOM was determined by acetaminophen-induced hepatotoxicity in Sprague-Dawley (Rattus novergicus) male rats. The methanol/fractions were also analysed by HPLC analysis for the presence of polyphenolics. RESULTS: The total phenolic content of the samples ranged from 19.3 ± 0.529 to 106.2 ± 0.892 mg GAE/g extract while total flavonoid content 16.2 ± 0.881 to 50.1 ± 1.764 mg RTE/g extract, respectively. FOA showed highest radical scavenging activity for DPPH (IC = 55.2 ± 1.212 µg/ml), ABTS (IC = 90.2 ± 1.232 µg/ml) superoxide (IC = 37.1 ± 0.643 µg/ml) and for H O (IC = 64 ± 1.463 µg/ml). FOE exhibited the highest antioxidant activities for phosphomolybdenum (IC = 78.2 ± 0.883 µg/ml) and for hydroxyl radical scavenging (IC = 82 ± 2.603 µg/ml). HPLC analysis of FOM and its derived fractions showed the presence of rutin, catechin and gallic acid. Elevated levels of AST, ALT, ALP, LDH and lipid profile in serum and lipid peroxidation and DNA damages in liver; while decreased activity level of CAT, SOD, GSH-Px, GR and reduced glutathione (GSH) concentration induced with acetaminophen in rat were reverted towards the control group with co-administration of FOM. CONCLUSION: Our results showed that F. olivieri is a potential source of natural antioxidants, which justifies its use in folklore medicine.
[Mh] Termos MeSH primário: Acetaminofen/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Fígado/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Substâncias Protetoras/administração & dosagem
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Antioxidantes/química
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Glutationa/metabolismo
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Masculino
Extratos Vegetais/química
Substâncias Protetoras/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 362O9ITL9D (Acetaminophen); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


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[PMID]:26820940
[Au] Autor:Jafri L; Saleem S; Calderwood D; Gillespie A; Mirza B; Green BD
[Ad] Endereço:Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan; Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: lailashah9@gmail.com.
[Ti] Título:Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion.
[So] Source:Peptides;78:51-8, 2016 Apr.
[Is] ISSN:1873-5169
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were tested for GLP-1 and GIP secretory activity in pGIP/neo STC-1 cells. Intracellular levels of incretin hormones and their gene expression were also determined. Crude F. cretica extracts stimulated both GLP-1 and GIP secretion, increased cellular hormone content, and upregulated gene expression of proglucagon, GIP and prohormone convertase. However, ethyl acetate partitioning significantly enriched GLP-1 secretory activity and this fraction underwent bioactivity-guided fractionation. Three isolated compounds were potent and selective GLP-1 secretagogues: quinovic acid (QA) and two QA derivatives, QA-3ß-O-ß-D-glycopyranoside and QA-3ß-O-ß-D-glucopyranosyl-(28→1)-ß-D-glucopyranosyl ester. All QA compounds activated the TGR5 receptor and increased intracellular incretin levels and gene expression. QA derivatives were more potent GLP-1 secretagogues than QA. This is the first time that QA and its naturally-occurring derivatives have been shown to activate TGR5 and stimulate GLP-1 secretion. These data provide a plausible mechanism for the ethnomedicinal use of F. cretica and may assist in the ongoing development of selective GLP-1 agonists.
[Mh] Termos MeSH primário: Células Enteroendócrinas/efeitos dos fármacos
Polipeptídeo Inibidor Gástrico/agonistas
Peptídeo 1 Semelhante ao Glucagon/agonistas
Hipoglicemiantes/farmacologia
Proglucagon/agonistas
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Linhagem Celular
Células Enteroendócrinas/citologia
Células Enteroendócrinas/metabolismo
Polipeptídeo Inibidor Gástrico/biossíntese
Polipeptídeo Inibidor Gástrico/genética
Polipeptídeo Inibidor Gástrico/secreção
Regulação da Expressão Gênica
Peptídeo 1 Semelhante ao Glucagon/biossíntese
Peptídeo 1 Semelhante ao Glucagon/genética
Peptídeo 1 Semelhante ao Glucagon/secreção
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Seres Humanos
Hipoglicemiantes/isolamento & purificação
Incretinas/agonistas
Incretinas/genética
Incretinas/metabolismo
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Proglucagon/biossíntese
Proglucagon/genética
Pró-Proteína Convertases/genética
Pró-Proteína Convertases/metabolismo
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/metabolismo
Transdução de Sinais
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (GPBAR1 protein, human); 0 (Glycosides); 0 (Hypoglycemic Agents); 0 (Incretins); 0 (Plant Extracts); 0 (Receptors, G-Protein-Coupled); 0 (Triterpenes); 55963-74-1 (Proglucagon); 59392-49-3 (Gastric Inhibitory Polypeptide); 89750-14-1 (Glucagon-Like Peptide 1); 9JP167T0ZN (quinovic acid); EC 3.4.21.- (Proprotein Convertases)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE


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[PMID]:26790586
[Au] Autor:Lauterbach M; van der Merwe PW; Keßler L; Pirie MD; Bellstedt DU; Kadereit G
[Ad] Endereço:Institut für Allgemeine und Spezielle Botanik, Johannes Gutenberg-Universität Mainz, 55099 Mainz, Germany. Electronic address: mlauter@uni-mainz.de.
[Ti] Título:Evolution of leaf anatomy in arid environments - A case study in southern African Tetraena and Roepera (Zygophyllaceae).
[So] Source:Mol Phylogenet Evol;97:129-144, 2016 Apr.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The dry biomes of southern Africa (Desert, Nama Karoo and Succulent Karoo) are home to a rich and diverse xerophytic flora. This flora includes two morphologically diverse clades of Zygophyllaceae, Tetraena and Roepera (Zygophylloideae), which inhabit some of the most arid habitats in the region. Using a plastid phylogeny of Zygophylloideae we assess whether the evolution of putatively adaptive traits (leaf shape, vasculature, mode of water storage and photosynthetic type: C3 versus C4) coincides with the successful colonisation of environments with different drought regimes within southern Africa. Our results show general niche conservatism within arid habitats in Tetraena, but niche shifts from arid to more mesic biomes with longer and/or cooler growing season (Fynbos and Thicket) in Roepera. However, these distinct broad-scale biogeographical patterns are not reflected in leaf anatomy, which seems to vary at more local scales. We observed considerable variability and multiple convergences to similar leaf anatomies in both genera, including shifts between "all cell succulence" leaf types and leaf types with distinct chlorenchyma and hydrenchyma. Our survey of C4 photosynthesis in the Zygophylloideae showed that the C4 pathway is restricted to Tetraena simplex, which also having an annual life history and a widespread distribution, is rather atypical for this group.
[Mh] Termos MeSH primário: Evolução Biológica
Clima Desértico
Ecossistema
Folhas de Planta/anatomia & histologia
Zygophyllaceae/anatomia & histologia
Zygophyllaceae/classificação
[Mh] Termos MeSH secundário: África Austral
Secas
Fenótipo
Fotossíntese
Filogenia
Filogeografia
Plastídeos/genética
Zygophyllaceae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170730
[Lr] Data última revisão:
170730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE


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[PMID]:26758711
[Au] Autor:Khan T; Abbasi BH; Khan MA; Shinwari ZK
[Ad] Endereço:Department of Biotechnology, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
[Ti] Título:Differential Effects of Thidiazuron on Production of Anticancer Phenolic Compounds in Callus Cultures of Fagonia indica.
[So] Source:Appl Biochem Biotechnol;179(1):46-58, 2016 Apr.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fagonia indica, a very important anticancer plant, has been less explored for its in vitro potential. This is the first report on thidiazuron (TDZ)-mediated callogenesis and elicitation of commercially important phenolic compounds. Among the five different plant growth regulators tested, TDZ induced comparatively higher fresh biomass, 51.0 g/100 mL and 40.50 g/100 mL for stem and leaf explants, respectively, after 6 weeks of culture time. Maximum total phenolic content (202.8 µg gallic acid equivalent [GAE]/mL for stem-derived callus and 161.3 µg GAE/mL for leaf-derived callus) and total flavonoid content (191.03 µg quercetin equivalent [QE]/mL for stem-derived callus and 164.83 µg QE/mL for leaf-derived callus) were observed in the optimized callus cultures. The high-performance liquid chromatography (HPLC) data indicated higher amounts of commercially important anticancer secondary metabolites such as gallic acid (125.10 ± 5.01 µg/mL), myricetin (32.5 ± 2.05 µg/mL), caffeic acid (12.5 ± 0.52 µg/mL), catechin (9.4 ± 1.2 µg/mL), and apigenin (3.8 ± 0.45 µg/mL). Owing to the greater phenolic content, a better 2-2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity (69.45 % for stem explant and 63.68 % for leaf explant) was observed in optimized calluses. The unusually higher biomass and the enhanced amount of phenolic compounds as a result of lower amounts of TDZ highlight the importance of this multipotent hormone as elicitor in callus cultures of F. indica.
[Mh] Termos MeSH primário: Antioxidantes/química
Fenóis/metabolismo
Extratos Vegetais/química
Zygophyllaceae/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/química
Antineoplásicos/metabolismo
Antioxidantes/farmacologia
Calo Ósseo/efeitos dos fármacos
Calo Ósseo/crescimento & desenvolvimento
Calo Ósseo/metabolismo
Técnicas de Cultura de Células
Flavonoides/química
Fenóis/química
Compostos de Fenilureia/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
Tiadiazóis/farmacologia
Zygophyllaceae/química
Zygophyllaceae/citologia
Zygophyllaceae/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Phenylurea Compounds); 0 (Plant Extracts); 0 (Thiadiazoles); 0091WH7STF (thidiazuron); 76XC01FTOJ (myricetin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170116
[Lr] Data última revisão:
170116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-1978-y


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[PMID]:26471558
[Au] Autor:Ma T; Hu N; Ding C; Zhang Q; Li W; Suo Y; Wang H; Bai B; Ding C
[Ad] Endereço:Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:In vitro and in vivo biological activities of anthocyanins from Nitraria tangutorun Bobr. fruits.
[So] Source:Food Chem;194:296-303, 2016 Mar 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anthocyanins are the main compounds in Nitraria tangutorun Bobr. The enrichment and purification of anthocyanins on macroporous resins were investigated. Regarding anthocyanin purification, static adsorption and desorption were studied. The optimal experimental conditions were the following: resin type: X-5; static adsorption time: 6h; desorption solution: ethanol-water-HCl (80:19:1, V/V/V; pH 1); desorption time: 40min. Furthermore, the in vitro and in vivo biological activities of the anthocyanins were evaluated. The anthocyanins showed ideal scavenging effects on free radicals in vitro, especially on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl free radical (OH). In the animal experiment, blood lipid metabolism of hyperlipidemia rats was regulated by anthocyanin contents. The superoxide dismutase (SOD) activity and the total antioxidant capacity (TAC) of hyperlipidemia rats were also improved by anthocyanins. These results showed that anthocyanins from N. tangutorun Bobr. fruits had potential biological activities in vivo as well as in vitro.
[Mh] Termos MeSH primário: Antocianinas/farmacologia
Antioxidantes/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Hiperlipidemias/tratamento farmacológico
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Animais
Antocianinas/isolamento & purificação
Antocianinas/uso terapêutico
Antioxidantes/isolamento & purificação
Antioxidantes/uso terapêutico
Compostos de Bifenilo/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/uso terapêutico
Radicais Livres/química
Frutas/química
Radical Hidroxila/química
Hiperlipidemias/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Malondialdeído/sangue
Oxirredução
Picratos/química
Extratos Vegetais/química
Ratos
Ratos Wistar
Superóxido Dismutase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Drugs, Chinese Herbal); 0 (Free Radicals); 0 (Picrates); 0 (Plant Extracts); 3352-57-6 (Hydroxyl Radical); 4Y8F71G49Q (Malondialdehyde); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151017
[St] Status:MEDLINE


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[PMID]:25921950
[Au] Autor:Qureshi H; Asif S; Ahmed H; Al-Kahtani HA; Hayat K
[Ad] Endereço:a Department of Botany , PMAS Arid Agriculture University , Rawalpindi 46000 , Pakistan.
[Ti] Título:Chemical composition and medicinal significance of Fagonia cretica: a review.
[So] Source:Nat Prod Res;30(6):625-39, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with serious side effects. Researchers, particularly of the Asian region elaborately studied the chemical composition and pharmacological activities of this plant. But further studies are still required to evaluate this plant in clinical trials in order to save humanity from synthetic chemical drugs yet disputed as 'friends or foe'.
[Mh] Termos MeSH primário: Extratos Vegetais/farmacologia
Plantas Medicinais/química
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Animais
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Medicina Ayurvédica
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Sapogeninas/química
Sapogeninas/isolamento & purificação
Saponinas/química
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Sapogenins); 0 (Saponins)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150430
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1036268


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[PMID]:26552870
[Au] Autor:Shehab NG; Abu-Gharbieh E; Bayoumi FA
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Naglaa_shehab@hotmail.com.
[Ti] Título:Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants.
[So] Source:BMC Complement Altern Med;15:401, 2015 Nov 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Flavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity. OBJECTIVE: To compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Salsola imbricata Forssk. in correlation to their composition especially their phenolic content. METHODS: The influence of extracting solvent on total phenolic and flavonoidal contents was assessed spectrophotometrically. The flavonoid and other polyphenolic components of the methanol extracts were analyzed by RP-HPLC. DPPH radical scavenging potential of the different extracts was estimated. The hepatoprotective and antioxidant activities of the extracts against CCl4-induced hepatotoxicity in mice were evaluated. RESULTS: The flavonol quercitrin and rosmarinic acid were major in the F. indica, C. procera and S. imbricata samples, while rutin prevailed in that of Z. hamiense. The ethanolic and methanolic extracts showed noticeable DPPH radical-scavenging activity as compared to ascorbic acid. Assessment of liver enzymes revealed that oral administration of the extracts did not show any evidence of hepatotoxicity. Moreover, protection against CCl4-induced liver damage was evident upon administration of three plants extracts namely, F. indica, C. procera and S. imbricata. CONCLUSION: Overall, hepatotoxicity induced by CCl4 was effectively prevented by the three plants extracts through scavenging of free radicals and by boosting the antioxidant capacity of the liver. The protective effect of the plants could be attributed to their high quercitrin and rosmarinic acid contents.
[Mh] Termos MeSH primário: Antioxidantes/química
Calotropis/química
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Fenóis/química
Extratos Vegetais/química
Substâncias Protetoras/química
Salsola/química
Zygophyllaceae/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Clima Desértico
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/enzimologia
Masculino
Camundongos
Fenóis/administração & dosagem
Extratos Vegetais/administração & dosagem
Plantas Medicinais/química
Substâncias Protetoras/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151111
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0919-6



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