Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.987.088 [Categoria DeCS]
Referências encontradas : 38 [refinar]
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[PMID]:28880962
[Au] Autor:Gaisberger H; Kindt R; Loo J; Schmidt M; Bognounou F; Da SS; Diallo OB; Ganaba S; Gnoumou A; Lompo D; Lykke AM; Mbayngone E; Nacoulma BMI; Ouedraogo M; Ouédraogo O; Parkouda C; Porembski S; Savadogo P; Thiombiano A; Zerbo G; Vinceti B
[Ad] Endereço:Bioversity International, Via dei Tre Denari 472/a, Maccarese (Rome), Italy.
[Ti] Título:Spatially explicit multi-threat assessment of food tree species in Burkina Faso: A fine-scale approach.
[So] Source:PLoS One;12(9):e0184457, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Over the last decades agroforestry parklands in Burkina Faso have come under increasing demographic as well as climatic pressures, which are threatening indigenous tree species that contribute substantially to income generation and nutrition in rural households. Analyzing the threats as well as the species vulnerability to them is fundamental for priority setting in conservation planning. Guided by literature and local experts we selected 16 important food tree species (Acacia macrostachya, Acacia senegal, Adansonia digitata, Annona senegalensis, Balanites aegyptiaca, Bombax costatum, Boscia senegalensis, Detarium microcarpum, Lannea microcarpa, Parkia biglobosa, Sclerocarya birrea, Strychnos spinosa, Tamarindus indica, Vitellaria paradoxa, Ximenia americana, Ziziphus mauritiana) and six key threats to them (overexploitation, overgrazing, fire, cotton production, mining and climate change). We developed a species-specific and spatially explicit approach combining freely accessible datasets, species distribution models (SDMs), climate models and expert survey results to predict, at fine scale, where these threats are likely to have the greatest impact. We find that all species face serious threats throughout much of their distribution in Burkina Faso and that climate change is predicted to be the most prevalent threat in the long term, whereas overexploitation and cotton production are the most important short-term threats. Tree populations growing in areas designated as 'highly threatened' due to climate change should be used as seed sources for ex situ conservation and planting in areas where future climate is predicting suitable habitats. Assisted regeneration is suggested for populations in areas where suitable habitat under future climate conditions coincides with high threat levels due to short-term threats. In the case of Vitellaria paradoxa, we suggest collecting seed along the northern margins of its distribution and considering assisted regeneration in the central part where the current threat level is high due to overexploitation. In the same way, population-specific recommendations can be derived from the individual and combined threat maps of the other 15 food tree species. The approach can be easily transferred to other countries and can be used to analyze general and species specific threats at finer and more local as well as at broader (continental) scales in order to plan more selective and efficient conservation actions in time. The concept can be applied anywhere as long as appropriate spatial data are available as well as knowledgeable experts.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
Alimentos
[Mh] Termos MeSH secundário: Acacia
Adansonia
Anacardiaceae
Annona
Balanites
Bombax
Burkina Faso
Mudança Climática
Ecossistema
Olacaceae
Tamarindus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184457


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[PMID]:28236195
[Au] Autor:Yassin AM; El-Deeb NM; Metwaly AM; El Fawal GF; Radwan MM; Hafez EE
[Ad] Endereço:Biopharmaceutical Product Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab City, Alexandria, 21934, Egypt.
[Ti] Título:Induction of Apoptosis in Human Cancer Cells Through Extrinsic and Intrinsic Pathways by Balanites aegyptiaca Furostanol Saponins and Saponin-Coated SilverNanoparticles.
[So] Source:Appl Biochem Biotechnol;182(4):1675-1693, 2017 Aug.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this investigation is to examine the anticancer activities of Balanites aegyptiaca fruit extract with its biogenic silver nanoparticles (AgNPs) against colon and liver cancer cells. B. aegyptiaca aqueous extract was fractionated according to polarity and by biosynthesized AgNP. The cytotoxicity of the extract, semi-purified fractions, and the AgNPs was examined on noncancerous cell lines. The safer fraction was subjected to ultra-performance liquid chromatography-MS to identify the major active constituents. The anticancer activities of the nontoxic doses of all the used treatments were tested against HepG2 and CaCo2 cells. The nontoxic dose of the B. aegyptiaca (0.63 mg/ml) extract showed high anti-proliferative activities against HepG2 and CaCo2 with a percentage of 81 and 77%, respectively. The butanol fraction was safer than the other two fractions with 46.3 and 90.35% anti-proliferative activity against Caco2 and HepG2 cells, respectively. The nontoxic dose of AgNPs (0.63 mg/ml) inhibits both HepG2 and Caco2 cells with a percentage of 84.5 and 83.4%, respectively. In addition, AgNPs regulate the expression of certain genes with folding higher than that of crude extract. Saponin-coated AgNPs showed great abilities to select the most anticancer ingredient(s) from the B. aegyptiaca extract with a more safety pattern than the polarity gradient fractionation.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Balanites/química
Nanopartículas Metálicas/química
Saponinas/química
Saponinas/farmacologia
Prata/química
Esteróis/química
Esteróis/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Células CACO-2
Proliferação Celular/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células Hep G2
Seres Humanos
Espaço Intracelular/efeitos dos fármacos
Espaço Intracelular/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Reactive Oxygen Species); 0 (Saponins); 0 (Sterols); 0 (furostanol saponin I); 059QF0KO0R (Water); 3M4G523W1G (Silver)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-017-2426-3


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[PMID]:27760539
[Au] Autor:Hassan LE; Dahham SS; Saghir SA; Mohammed AM; Eltayeb NM; Majid AM; Majid AS
[Ad] Endereço:EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
[Ti] Título:Chemotherapeutic potentials of the stem bark of Balanite aegyptiaca (L.) Delile: an antiangiogenic, antitumor and antioxidant agent.
[So] Source:BMC Complement Altern Med;16(1):396, 2016 Oct 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Balanite aegyptiaca (L.) Delile, is a plant with extensive medicinal properties. Its stem bark is traditionally known for its spasmolytic and antiepileptic properties and used to treat yellow fever, jaundice and syphilis. Angiogenesis (sprouting of new blood vessels) is crucial for tumor growth and metastasis. The goal of this study is investigate the antiangiogenic, cytotoxicity and antioxidant activity as well as antitumor in vivo properties of B. aegyptiaca stem bark extracts. METHOD: The dried powder of stem bark was extracted sequentially with n-hexane, chloroform, methanol and water. Rat aorta ring assay (RARA) was used as a platform to screen for antiangiogenic affect. The most active extract was subjected to further confirmatory antiangiogenic tests i.e. cell migration, tube formation and VEGF inhibition and finally evaluated for its in vivo antitumor efficacy in nude mice. The cytotoxicity of extracts on four cancer cell lines (HCT-116, K562, U937 and MCF-7) and one normal cells line (HUVEC) was evaluated. To assess the antioxidant activity screening, four methods were used, (DPPH•) and ABTS radical scavenging activity, as well as total flavonoids and phenolic contents. RESULTS: Methanol extract of B. aegyptiaca stem bark (MBA) showed the highest antiangiogenic, antioxidant and anticancer properties. It was found selectively cytotoxic to leukemia cell lines as well as breast cancer cell line MCF-7. (MBA) thus exhibited antiangiogenic in ex-vivo rat aorta ring model; it was found to excel its antiangiogenic effect via inhibition of the key growth factor (VEGF) as well as to halt HUVEC cell migration and tube formation, furthermore animals bearing colon cancer treated with (MBA) showed significant reduction in tumor growth. CONCLUSION: Different extracts of B. aegyptiaca stem bark showed various anticancer and antiangiogenic properties. MBA demonstrated potent antiangiogenic, antioxidant and antitumor in vivo. The outcome of this study suggests the potential of stem bark of the B. aegyptiaca for developing chemotherapeutic agent against solid tumor as well as leukemia.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Antioxidantes/farmacologia
Balanites/química
Casca de Planta/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/química
Animais
Antioxidantes/química
Aorta/citologia
Aorta/efeitos dos fármacos
Aorta/fisiologia
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Células MCF-7
Masculino
Camundongos
Camundongos Nus
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27019854
[Au] Autor:Abou Khalil NS; Abou-Elhamd AS; Wasfy SI; El Mileegy IM; Hamed MY; Ageely HM
[Ad] Endereço:Department of Physiology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt.
[Ti] Título:Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats.
[So] Source:J Diabetes Res;2016:8408326, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts of Balanites aegyptiaca and Petroselinum sativum extracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancreas and the size of the islets of Langerhans and improvement in the histoarchitecture were evident in the treated groups compared to untreated ones. In conclusion, the present study provides a scientific evidence for the traditional use of these extracts as antidiabetic and antioxidant agents in type 1 diabetes mellitus.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Balanites/química
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 1/tratamento farmacológico
Hipoglicemiantes/farmacologia
Petroselinum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Biomarcadores/sangue
Glicemia/efeitos dos fármacos
Glicemia/metabolismo
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/diagnóstico
Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 1/diagnóstico
Frutas
Hipoglicemiantes/isolamento & purificação
Insulina/sangue
Masculino
Estresse Oxidativo/efeitos dos fármacos
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Plantas Medicinais
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170618
[Lr] Data última revisão:
170618
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160329
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8408326


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[PMID]:26275727
[Au] Autor:Farag MA; Porzel A; Wessjohann LA
[Ad] Endereço:Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Kasr el Aini St., P.B. 11562, Egypt. Electronic address: mohamed.farag@pharma.cu.edu.eg.
[Ti] Título:Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR.
[So] Source:J Pharm Biomed Anal;115:383-7, 2015 Nov 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trigonelline (3-carboxy-1-methyl pyridinium) was identified as a relevant bioactivity and taste imparting component in Balanites aegyptiaca fruit, using (1)H NMR of crude extracts without any fractionation or isolation step. The structural integrity of trigonelline was established within the extract matrix via(1)H NMR, (1)H-(1)H COSY, HMQC and HMBC and by comparison with authentic standard. A quantitative (1)H NMR method (qHNMR) was used to determine trigonelline concentrations in the peel and pulp of B. aegyptiaca fruit of 8 and 13mgg(-1), respectively. Trigonelline so far has not been reported from B. aegyptiaca or its genus as it easily escapes LC-MS based detection. Its discovery provides novel insight into the balanite fruits antidiabetic properties as the compound is known for a pronounced hypoglycemic effect. In addition, it is likely to impart the perceptible bitter taste portion to balanites sweet bitter taste. UPLC-MS of the crude extract additionally revealed the fruit flavonoid pattern showing quercetin/isorhamnetin flavonol conjugates in addition to epicatechin, the latter being present at much lower levels.
[Mh] Termos MeSH primário: Alcaloides/análise
Balanites/química
Hipoglicemiantes/análise
Metabolômica/métodos
Extratos Vegetais/análise
Espectroscopia de Prótons por Ressonância Magnética
[Mh] Termos MeSH secundário: Cromatografia Líquida
Frutas
Espectrometria de Massas
Metabolômica/normas
Estrutura Molecular
Espectroscopia de Prótons por Ressonância Magnética/normas
Padrões de Referência
Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 3NQ9N60I00 (trigonelline)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150921
[Lr] Data última revisão:
150921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150816
[St] Status:MEDLINE


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[PMID]:26262605
[Au] Autor:Al-Malki AL; Barbour EK; Abulnaja KO; Moselhy SS
[Ad] Endereço:Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80205, Jeddah 22254, Saudi Arabia. alalmalki@kau.edu.sa.
[Ti] Título:Management of Hyperglycaemia by Ethyl Acetate Extract of Balanites aegyptiaca (Desert Date).
[So] Source:Molecules;20(8):14425-34, 2015 Aug 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Reactive oxygen species play a significant role in the pathogenesis of retinopathy in diabetes patients. The current study aimed to assess the effect of ethyl acetate extract (EAE) from Balanites aegyptiaca (10, 25 or 50 mg/kg b.w.) in experimental diabetic rats. To achieve this aim, five groups of male rats were included: control, diabetic, and diabetic rats treated with 10, 25, and 50 µg/kg b.w. of EAE for eight weeks. Our results suggests a protective role of EAE against oxidative stress induced by streptozocine. EAE treatment produced a reduction in blood glucose levels, HbA1c, malondialdehyde and vascular endothelial growth factor (VEGF) in diabetic retina (p < 0.001), as well as an enhancement in antioxidant capacity against streptozocine-induced oxidative stress. Tumor necrosis factor alpha (TNF-α), interleukin (IL-1ß) and vascular endothelial growth factor (VEGF) were significantly reduced in diabetic rats treated with EAE, compared with untreated diabetic rats. Analysis of EAE by GC-MS indicated the presence of ß-sistosterol. Overall, EAE modulates oxidative stress induced by streptozocine and enhances antioxidant activity, which may provide additional endothelial protection in retina of diabetic rats. These results hold great promise in the management of diabetic complications.
[Mh] Termos MeSH primário: Balanites/química
Diabetes Mellitus Experimental/tratamento farmacológico
Hiperglicemia/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos/química
Animais
Glicemia/metabolismo
Diabetes Mellitus Experimental/sangue
Retinopatia Diabética/sangue
Retinopatia Diabética/tratamento farmacológico
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Hiperglicemia/sangue
Masculino
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Blood Glucose); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150812
[Lr] Data última revisão:
150812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE
[do] DOI:10.3390/molecules200814425


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[PMID]:26220630
[Au] Autor:Abdel Motaal A; El-Askary H; Crockett S; Kunert O; Sakr B; Shaker S; Grigore A; Albulescu R; Bauer R
[Ad] Endereço:Faculty of Pharmacy, Cairo University, Kasr-El-Ainy St., Cairo 11562, Egypt; Faculty of Pharmacy and Drug Technology, Heliopolis University, 2834 El Horreya, Cairo, Egypt. Electronic address: a_motaal@hotmail.com.
[Ti] Título:Aldose reductase inhibition of a saponin-rich fraction and new furostanol saponin derivatives from Balanites aegyptiaca.
[So] Source:Phytomedicine;22(9):829-36, 2015 Aug 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are used to treat hyperglycemia in Egyptian folk medicine and are sold by herbalists in the Egyptian open market for this purpose. Nevertheless, the fruits have not yet been incorporated into pharmaceutical dosage forms. The identity of the bioactive compounds and their possible mechanisms of action were not well understood until now. PURPOSE: Aldose reductase inhibitors are considered vital therapeutic and preventive agents to address complications caused by hyperglycemia. The present study was carried out to identify the primary compounds responsible for the aldose reductase inhibitory activity of Balanites aegyptiaca fruits. STUDY DESIGN: The 70% ethanolic extract of Balanites aegyptiaca fruit mesocarp and its fractions were screened for inhibition of the aldose reductase enzyme. Bio-guided fractionation of the active butanol fraction was performed and the primary compounds present in the saponin-rich fraction (D), which were responsible for the inhibitory activity, were characterized. HPLC chromatographic profiles were established for the different fractions, using the isolated compounds as biomarkers. METHODS: Aldose reductase inhibition was tested in vitro on rat liver homogenate. The butanol fraction of the 70% ethanolic extract was fractionated using vacuum liquid chromatography (VLC, RP-18 column). The most active sub-fraction D, which was eluted with 75% methanol, was subjected to preparative HPLC to isolate the bioactive compounds. RESULTS: The butanol fraction displayed inhibitory activity against the aldose reductase enzyme (IC50 = 55.0 ± 6 µg/ml). Sub-fraction D exhibited the highest inhibitory activity (IC50 = 12.8 ± 1 µg/ml). Five new steroidal saponin derivatives were isolated from this fraction. The isolated compounds were identified as compound 1a/b, a 7:3 mixture of the 25R:25S epimers of 26-O-ß-D-glucopyranosyl-furost-5-ene-3,22,26-triol 3-O-[α-L-rhamnopyranosyl-(1→3)- ß-D-glucopyranosyl-(1→2)]- α-L-rhamnopyranosyl-(1→4)-ß-D-glucopyranoside; compound 2, 26-O-ß-D-glucopyranosyl-(25R)-furost-5-ene-3,22,26-triol 3-O-[ ß-D-glucopyranosyl-(1→2)]- α-L-rhamnopyranosyl-(1→4)-ß-D-glucopyranoside; compound 3, 26-O-ß-D-glucopyranosyl-(25R)-furost-5,20-diene-3,26-diol 3-O-[α-L-rhamnopyranosyl-(1→3)- ß-D-glucopyranosyl-(1→2)]- α-L-rhamnopyranosyl-(1→4)-ß-D-glucopyranoside; compound 4, 26-O-ß-D-glucopyranosyl-(25R)-furost-5,20-diene-3,26-diol 3-O-[ ß-D-glucopyranosyl-(1→2)]- α-L-rhamnopyranosyl-(1→4)-ß-D-glucopyranoside; and compound 5, which is the 25S epimer of compound 4, by using various spectroscopic methods [MS,1D and 2D NMR (HSQC, HMBC, DQF-COSY, HSQC-TOCSY)]. Compounds 1a/b, 2, 3, 4, 5 exhibited highly significant aldose reductase inhibitory activities (IC50 values were 1.9 ± 0.2, 1.3 ± 0.5, 5.6 ± 0.2, 5.1 ± 0.4, 5.1 ± 0.6 µM, respectively) as compared to the activity of the reference standard quercetin (IC50 = 6.6 ± 0.3 µM). CONCLUSION: The aldose reductase inhibitory activity of Balanites fruits is due to the steroidal saponins present. HPLC chromatographic profiles of the crude butanol fraction and its 4 sub-fractions showed that the most highly bioactive fraction D contained the highest amount of steroidal saponins (75%) as compared to the 21% present in the original butanol fraction. The isolated furostanol saponins proved to be highly active in an in vitro assay.
[Mh] Termos MeSH primário: Aldeído Redutase/antagonistas & inibidores
Balanites/química
Extratos Vegetais/química
Saponinas/química
Esteróis/química
[Mh] Termos MeSH secundário: Aldeído Redutase/química
Animais
Inibidores Enzimáticos/química
Frutas/química
Fígado/enzimologia
Estrutura Molecular
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (Saponins); 0 (Sterols); EC 1.1.1.21 (Aldehyde Reductase)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150729
[Lr] Data última revisão:
150729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150730
[St] Status:MEDLINE


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[PMID]:26095745
[Au] Autor:Issa NM; Mansour FK; El-Safti FA; Nooh HZ; El-Sayed IH
[Ad] Endereço:Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Egypt.
[Ti] Título:Effect of Balanites aegyptiaca on Ehrlich Ascitic carcinoma growth and metastasis in Swiss mice.
[So] Source:Exp Toxicol Pathol;67(9):435-41, 2015 Sep.
[Is] ISSN:1618-1433
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The role of Balanites aegyptiaca (B. aegyptiaca) on development and growth of Ehrlich Ascitic carcinoma (EAC) and metastasis (liver and spleen) was evaluated. Balanite (400mg/kg; 10mg in 0.1ml/mouse) was given daily over a period of two weeks started 24h before intraperitoneal injection of EAC (2×10(6)/once). The present study deals with the effect of B. aegyptiaca on the growth of transplantable ascetic tumor, life span of EAC-bearing mice, hepatocellular and splenic histology. Antioxidant and biochemical changes as well as p53 genes expression were recorded. B. aegyptiaca extracts inhibited tumor growth and proliferation in ascetic fluid through a significant decrease in tumor volume, total cell volume, and viable cell count and prolonged the life span of mice. Also, it significantly decreased the levels of lipid peroxidation and increased SOD, CAT levels and P53 expression. Also, balanite inhibited either tumor invaded/or affected hepatic and splenic tissue. This result gives a new insight on beneficial effect of B. aegyptiaca in primary and secondary loci of Ehrlich Ascitic tumor through its antioxidant effect.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Balanites/química
Carcinoma de Ehrlich/tratamento farmacológico
Neoplasias Hepáticas/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Neoplasias Esplênicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/isolamento & purificação
Carcinoma de Ehrlich/patologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Feminino
Frutas/química
Neoplasias Hepáticas/secundário
Camundongos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Neoplasias Esplênicas/secundário
Resultado do Tratamento
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150912
[Lr] Data última revisão:
150912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE


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[PMID]:25666430
[Au] Autor:Anani K; Adjrah Y; Ameyapoh Y; Karou SD; Agbonon A; de Souza C; Gbeassor M
[Ad] Endereço:Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires, Ecole Supérieure des Techniques Biologiques et Alimentaires - Université de Lomé, B.P. 1515 Lomé, Togo; Centre de Formation et de Recherche sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo; Centre de Re
[Ti] Título:Effects of hydroethanolic extracts of Balanites aegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds.
[So] Source:J Ethnopharmacol;164:16-21, 2015 Apr 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The bark of Balanites aegyptiaca (L.) Delile (Balanitaceae) is widely used in the Togolese folk medicine for the treatment of wounds, malaria and skin diseases. This study aimed to evaluate the antioxidant properties and the activity of the bark extract of this plant against some resistant bacteria isolated from wounds. MATERIALS AND METHODS: The antimicrobial activity was assayed using the NCCLS microdilution while the DPPH free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. The susceptibility to conventional antibiotics of bacteria was assessed by an agar disk diffusion method using commercial disk. Phenolics were quantified using spectrophotometric methods. RESULTS: The hydroethanolic extracts of the bark inhibited in vitro the growth of Pseudomonas aeruginosa and Staphylococcus aureus in a dose-dependent manner. Bacteriostatic effects were observed on 15 (33%) and 21 (47%) strains of Staphylococcus aureus and Pseudomonas aeruginosa respectively. The MICs and MBCs against Staphylococcus aureus strains ranged respectively from 2.5 to 12.5 µg/mL and 2.5 to 50 µg/mL. Concerning Pseudomonas aeruginosa, these values were equal (12.5 µg/mL). Multidrug resistance was 95% against six antibiotics for Pseudomonas aeruginosa and 91% against five antibiotics for Staphylococcus aureus. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity, closely linked with the total phenolic contents. CONCLUSION: This study indicated that the bark extract of Balanites aegyptiaca possess bioactive compounds implicated in the free radical scavenging and antibacterial activities, justifying the use of the plant in the traditional medicines.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Balanites
Depuradores de Radicais Livres/farmacologia
Extratos Vegetais/farmacologia
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Farmacorresistência Bacteriana
Testes de Sensibilidade Microbiana
Casca de Planta
Pseudomonas aeruginosa/crescimento & desenvolvimento
Staphylococcus aureus/crescimento & desenvolvimento
Ferimentos e Lesões/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Free Radical Scavengers); 0 (Plant Extracts)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150325
[Lr] Data última revisão:
150325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150211
[St] Status:MEDLINE


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[PMID]:23905025
[Au] Autor:Molla E; Giday M; Erko B
[Ad] Endereço:Dilla University, P.O. Box 419, Dilla, Ethiopia.
[Ti] Título:Laboratory assessment of the molluscicidal and cercariacidal activities of Balanites aegyptiaca.
[So] Source:Asian Pac J Trop Biomed;3(8):657-62; discussion 661, 2013 Aug.
[Is] ISSN:2221-1691
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the molluscicidal and cercariacidal activities of aqueous extracts of Balanites aegyptiaca (B. aegyptiaca) against Ethiopian Biomphalaria pfeifferi (B. pfeifferi), Lymnaea natalensis (L. natalensis) and Schistosoma mansoni (S. mansoni) cercariae. METHODS: Extracts of seeds, endocarp, mesocarp, and fruit of B. aegyptiaca were tested for their activities against adult B. pfeifferi and L. natalensis. The cercariacidal activity of the seeds of the plant was also evaluated against S. mansoni. Bioassays were carried out following the methods recommended by WHO. Snail mortalities were compared between each plant part and snail species, and LC50 and LC90 values for the plant parts tested were computed. The cercariacidal activity of the plant was assessed by exposing the mice to the cercariae pre-exposed to aqueous extract of B. aegyptiaca seeds. RESULTS: For the molluscicidal activities of seeds, endocarp, mesocarp and whole fruit, the LC50 values against B. pfeifferi were 56.32, 77.53, 65.51 and 66.63 mg/L, respectively, while the respective LC90 values were 77.70, 120.04, 89.50 and 97.55 mg/L. Similarly, the LC50 values for the seeds, endocarp, mesocarp and whole fruit against L. natalensis were 80.33, 92.61, 83.52 and 87.84 mg/L, respectively, while the respective LC90 values were 102.30, 138.21, 115.42 and 127.69 mg/L. B. pfeifferi were found to be more susceptible to B. aegyptiaca than L. natalensis. S. mansoni cercariae exposed to 15 mg/L of extract of seeds were incapable of infecting mice. The mean egg load of tissue was reduced in mice infected with the cercariae exposed to 5 and 10 mg/L of the extract. CONCLUSIONS: The aqueous extracts of different parts of B. aegyptiaca exhibited reasonable molluscicidal activity against B. pfeifferi and L. natalensis, as well as cercariacidal activity against S. mansoni cercariae. However, comprehensive laboratory evaluation is recommended prior to field tests of the plant parts since their impact on other aquatic biota is not known.
[Mh] Termos MeSH primário: Antiplatelmínticos/farmacologia
Balanites/química
Moluscocidas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomphalaria/efeitos dos fármacos
Cercárias/efeitos dos fármacos
Dose Letal Mediana
Lymnaea/efeitos dos fármacos
Camundongos
Contagem de Ovos de Parasitas
Schistosoma mansoni/efeitos dos fármacos
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiplatyhelmintic Agents); 0 (Molluscacides); 0 (Plant Extracts)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130802
[St] Status:MEDLINE
[do] DOI:10.1016/S2221-1691(13)60132-X



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