Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.987.399 [Categoria DeCS]
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  1 / 107 MEDLINE  
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[PMID]:28793307
[Au] Autor:Bashyal B; Li L; Bains T; Debnath A; LaBarbera DV
[Ad] Endereço:Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
[Ti] Título:Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.
[So] Source:PLoS Negl Trop Dis;11(8):e0005832, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Protozoan parasites infect and kill millions of people worldwide every year, particularly in developing countries where access to clean fresh water is limited. Among the most common are intestinal parasites, including Giardia lamblia and Entamoeba histolytica. These parasites wreak havoc on the epithelium lining the small intestines (G. lamblia) and colon (E. histolytica) causing giardiasis and amebiasis, respectively. In addition, there are less common but far more deadly pathogens such as Naegleria fowleri that thrive in warm waters and infect the central nervous systems of their victims via the nasal passages. Despite their prevalence and associated high mortality rates, there remains an unmet need to identify more effective therapeutics for people infected with these opportunistic parasites. To address this unmet need, we have surveyed plants and traditional herbal medicines known throughout the world to identify novel antiparasitic agents with activity against G. lamblia, E. histolytica, and N. fowleri. Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic activity against all three pathogens. This report also characterizes the lignan compound classes, nordihydroguairetic acid and demethoxyisoguaiacin, as novel antiparasitic lead agents to further develop more effective drug therapy options for millions of people worldwide.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Entamoeba histolytica/efeitos dos fármacos
Giardia lamblia/efeitos dos fármacos
Larrea/química
Naegleria fowleri/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antiprotozoários/química
Antiprotozoários/isolamento & purificação
Seres Humanos
Masoprocol/isolamento & purificação
Masoprocol/farmacologia
Naftóis/isolamento & purificação
Naftóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Naphthols); 0 (Plant Extracts); 0 (demethoxyisoguaiacin); 7BO8G1BYQU (Masoprocol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005832


  2 / 107 MEDLINE  
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[PMID]:28226316
[Au] Autor:Alonso MR; Anesini C
[Ad] Endereço:Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR®.
[So] Source:Skin Pharmacol Physiol;30(1):46-54, 2017.
[Is] ISSN:1660-5535
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. An association of extracts of Coffea arabica and Larrea divaricata (ECOHAIR®) is successfully being commercialized in Argentina for hair growth. The aim of this study was to provide scientific support for the efficacy and innocuousness of ECOHAIR® in patients with noncicatricial alopecia during a 3-month treatment. METHODS: The efficacy was determined through the assessment of an increase in hair volume, improvement in hair looks, growth of new hair, and a decrease in hair loss by the test of hair count and hair traction. The capacity to decrease the amount of dandruff was also evaluated as well as the adverse local effects caused by the treatment. RESULTS: ECOHAIR® spray improved the overall hair volume and appearance; it increased its thickness, induced hair growth, and decreased hair loss. Besides, no adverse local reactions were observed upon treatment with the product. CONCLUSION: This study provides scientific support for the clinical use of ECOHAIR® as a treatment to be used in noncicatricial alopecia.
[Mh] Termos MeSH primário: Alopecia/tratamento farmacológico
Coffea
Larrea
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Cabelo/efeitos dos fármacos
Cabelo/crescimento & desenvolvimento
Seres Humanos
Masculino
Meia-Idade
Fitoterapia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; CLINICAL TRIAL, PHASE IV; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1159/000455958


  3 / 107 MEDLINE  
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[PMID]:28058783
[Au] Autor:Jeong H; Kim S; Lee J; Park JY; Zhou W; Liu X; Kim SD; Song YS; Jang CY; Oh SR; Choi S; Chang M
[Ad] Endereço:Graduate School of Biological Sciences, Sookmyung Women's University, 100, Chungparo 47-gil, Seoul, 140-742, Korea.
[Ti] Título:Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds.
[So] Source:Phytother Res;31(1):140-151, 2017 Jan.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Larrea nitida Cav. (LNC), which belongs to the family Zygophyllaceae, is widely indigenous and used in South America to treat various pathological conditions. It contains the antioxidant and antiinflammatory but toxic nordihydroguaiaretic acid (NDGA) as well as O-methylated metabolite of NDGA (MNDGA) as bioactive compounds. The hepatic metabolism-based toxicological potential of extracts of LNC (LNE), NDGA, and MNDGA has not previously been reported. The present study aimed to characterize the phase I and phase II hepatic metabolism and reactive intermediates of LNE, NDGA, and MNDGA and their effects on the major drug-metabolizing enzymes in vitro and ex vivo. A methanol extract of LNC collected from Chile as well as NDGA and MNDGA isolated from LNE were subjected to metabolic stability assays in liver microsomes in the presence of the cofactors reduced nicotinamide dinucleotide phosphate (NADPH) and/or uridine 5'-diphosphoglucuronic acid (UDPGA). Cytochrome P450 (CYP) inhibition assays were performed using CYP isozyme-specific model substrates to examine the inhibitory activities of LNE, NDGA, and MNDGA, which were expressed as % inhibition and IC values. Ex vivo CYP induction potential was investigated in the liver microsomes prepared from the rats intraperitoneally administered with LNE. Glutathione (GSH) adduct formation was monitored by LC-MS analysis of the microsomal incubation samples with either NDGA or MNDGA and an excess of GSH to determine the formation of electrophilic reactive intermediates. Both NDGA and MNDGA were stable to NADPH-dependent phase I metabolism, but labile to glucuronide conjugation. LNE, NDGA, and MNDGA showed significant inhibitory effects on CYP1A2, 2C9, 2D6, and/or 3A4, with IC values in the micromolar range. LNE was found to be a CYP1A2 inducer in ex vivo rat experiments, and mono- and di-GSH adducts of both NDGA and MNDGA were identified by LC-MS analysis. Our study suggests that hepatic clearance is the major elimination route for the lignans NDGA and MNDGA present in LNE. These lignans may possess the ability to modify biomacromolecules via producing reactive intermediates. In addition, LNE, NDGA, and MNDGA are found to be inhibitors for various CYP isozymes such as CYP2C9 and 3A4. Thus, the consumption of LNC as an herbal preparation or NDGA may cause metabolism-driven herb-drug interactions. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Larrea/química
Lignanas/química
Fígado/metabolismo
Microssomos Hepáticos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Interações Ervas-Drogas
Seres Humanos
Lignanas/farmacologia
Ratos
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5742


  4 / 107 MEDLINE  
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[PMID]:28001217
[Au] Autor:Romero CM; Vivacqua CG; Abdulhamid MB; Baigori MD; Slanis AC; Allori MC; Tereschuk ML
[Ad] Endereço:Planta Piloto de Procesos Industriales Microbiológicos, Consejo Nacional de Investigaciones Científicas y Técnicas San Miguel de Tucumán, Tucumán, Argentina.
[Ti] Título:Biofilm inhibition activity of traditional medicinal plants from Northwestern Argentina against native pathogen and environmental microorganisms.
[So] Source:Rev Soc Bras Med Trop;49(6):703-712, 2016 Nov-Dec.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION:: Plants have been commonly used in popular medicine of most cultures for the treatment of disease. The in vitro antimicrobial activity of certain Argentine plants used in traditional medicine has been reported. The aim of this study was to investigate the antimicrobial, anti-biofilm, and anti-cell adherence activities of native plants (Larrea divaricata, Tagetes minuta, Tessaria absinthioides, Lycium chilense, and Schinus fasciculatus) collected in northwestern Argentina. METHODS:: The activities of the five plant species were evaluated in Bacillus strains and clinical strains of coagulase-negative Staphylococcus isolated from northwestern Argentina and identified by 16S rDNA. RESULT:: Lycium chilense and Schinus fasciculatus were the most effective antimicrobial plant extracts (15.62µg/ml and 62.50µg/ml for Staphylococcus sp. Mcr1 and Bacillus sp. Mcn4, respectively). The highest (66%) anti-biofilm activity against Bacillus sp. Mcn4 was observed with T. absinthioides and L. divaricate extracts. The highest (68%) anti-biofilm activity against Staphylococcus sp. Mcr1 was observed with L. chilense extract. T. minuta, T. absinthioides, and L. divaricata showed percentages of anti-biofilm activity of between 55% and 62%. The anti-adherence effects of T. minuta and L. chilense observed in Bacillus sp. Mcn4 reflected a difference of only 22% and 10%, respectively, between anti-adherence and biofilm inhibition. Thus, the inhibition of biofilm could be related to cell adherence. In Staphylococcus sp. Mcr1, all plant extracts produced low anti-adherence percentages. CONCLUSION:: These five species may represent a source of alternative drugs derived from plant extracts, based on ethnobotanical knowledge from northwest Argentina.
[Mh] Termos MeSH primário: Bacillus/efeitos dos fármacos
Biofilmes/efeitos dos fármacos
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Staphylococcus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anacardiaceae/química
Argentina
Biofilmes/crescimento & desenvolvimento
Adesão Celular/efeitos dos fármacos
Microbiologia Ambiental
Seres Humanos
Larrea/química
Lycium/química
Testes de Sensibilidade Microbiana
Plantas Medicinais/classificação
Tagetes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE


  5 / 107 MEDLINE  
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[PMID]:27440793
[Au] Autor:Laport RG; Minckley RL; Ramsey J
[Ad] Endereço:University of Nebraska-Lincoln, School of Biological Sciences, Lincoln, Nebraska 68588 USA rob.laport@gmail.com.
[Ti] Título:Ecological distributions, phenological isolation, and genetic structure in sympatric and parapatric populations of the Larrea tridentata polyploid complex.
[So] Source:Am J Bot;103(7):1358-74, 2016 07.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Polyploidy is widely recognized as a mechanism of diversification. Contributions of polyploidy to specific pre- and postzygotic barriers-and classifications of polyploid speciation as "ecological" vs. "non-ecological"-are more contentious. Evaluation of these issues requires comprehensive studies that test ecological characteristics of cytotypes as well as the coincidence of genetic structure with cytotype distributions. METHODS: We investigated a classical example of autopolyploid speciation, Larrea tridentata, at multiple areas of cytotype co-occurrence. Habitat and phenological differences were compared between diploid, tetraploid, and hexaploid populations on the basis of edaphic, community composition, and flowering time surveys. Frequency of hybridization between diploids and tetraploids was investigated using a diploid-specific chloroplast DNA (cpDNA) marker; genetic structure for all cytotypes was assessed using amplified fragment length polymorphisms (AFLPs). KEY RESULTS: Across contact zones, we found cytotypes in habitats distinguished by soil and vegetation. We observed modest differences in timing and production of flowers, indicating a degree of assortative mating that was asymmetric between cytotypes. Nonetheless, cpDNA analyses in diploid-tetraploid contact zones suggested that ∼5% of tetraploid plants had hybrid origins involving unilateral sexual polyploidization. Genetic structure of AFLPs largely coincided with cytotype distributions in diploid-tetraploid contact zones. In contrast, there was little structure in areas of contact between tetraploids and hexaploids, suggesting intercytotype gene flow or recurrent hexaploid formation. CONCLUSIONS: Diploid, tetraploid, and hexaploid cytotypes of L. tridentata are segregated by environmental distributions and flowering phenology in contact zones, with diploid and tetraploid populations having corresponding differences in genetic structure.
[Mh] Termos MeSH primário: Fluxo Gênico
Estruturas Genéticas
Larrea/genética
Poliploidia
[Mh] Termos MeSH secundário: Diploide
Ecologia
Ecossistema
Flores/anatomia & histologia
Flores/genética
Geografia
Hibridização Genética
Larrea/anatomia & histologia
Fenótipo
Simpatria
Tetraploidia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600105


  6 / 107 MEDLINE  
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[PMID]:27319135
[Au] Autor:Salasa A; Mercadoc MI; Zampini IC; Ponessa GI; Isla MI
[Ti] Título:Determination of Botanical Origin of Propolis from Monte Region of Argentina by Histological and Chemical Methods.
[So] Source:Nat Prod Commun;11(5):627-30, 2016 May.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Propolis production by honey bees is the result of a selective harvest of exudates from plants in the neighborhood of the hive. This product is used in Argentina as a food supplement and alternative medicine. The aim of this study was to determine the botanical origin of propolis from the arid regions of Monte of Argentina using rapid histochemical techniques and by comparison of TLC and HPLC-DAD chromatographic profiles with extract profiles obtained from Zuccagnia punctata, Larrea divaricata and Larrea cuneifolia, plant species that grow in the study area as a natural community named "jarillal". Microscopical analysis revealed the presence of several Z. punctata structures, such as multicellular trichomes, leaflets, stems and young leaves. Remarkable was the richness of the propolis in two bioactive chalcones, also present in Z. punctata resin; these compounds can be regarded as possible markers for propolis identification and justify its use as a dietary supplement, functional food and medicinal product. This study indicates that the source of resin used by honey bees to produce propolis in the Monte region of Argentina is only Z. punctata, a native shrub widespread in this phytogeographical region, while other more abundant species (L. divaricata and L. cuneifolia) in the region were not found, indicating that this propolis could be defined as a mono-resin, type-Zuccagnia.
[Mh] Termos MeSH primário: Fabaceae/citologia
Própole/análise
[Mh] Termos MeSH secundário: Argentina
Larrea/citologia
Própole/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9009-62-5 (Propolis)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160620
[Lr] Data última revisão:
160620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


  7 / 107 MEDLINE  
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[PMID]:27038396
[Au] Autor:Martino R; Arcos ML; Alonso R; Sülsen V; Cremaschi G; Anesini C
[Ad] Endereço:Instituto de Química y Metabolismo del Fármaco - IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 piso 2, 1113, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Polyphenol-Rich Fraction from Larrea divaricata and its Main Flavonoid Quercetin-3-Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress.
[So] Source:Phytother Res;30(7):1128-36, 2016 Jul.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Larrea divaricata is a plant with antiproliferative principles. We have previously identified the flavonoid quercetin-3-methyl ether (Q-3-ME) in an ethyl acetate fraction (EA). Both the extract and Q-3-ME were found to be effective against the EL-4 T lymphoma cell line. However, the mechanism underlying the inhibition of tumor cell proliferation remains to be elucidated. In this work, we analyzed the role of nitric oxide (NO) in the induction of apoptosis mediated by Q-3-ME and EA. Both treatments were able to induce apoptosis in a concentration-dependent and time-dependent manner. The western blot analysis revealed a sequential activation of caspases-9 and 3, followed by poly-(ADP-ribose)-polymerase cleavage. EA and Q-3-ME lowered the mitochondrial membrane potential, showing the activation of the intrinsic pathway of apoptosis. Q-3-ME and EA increased NO production and inducible NO synthase expression in tumor cells. The involvement of NO in cell death was confirmed by the nitric oxide synthases inhibitor L-NAME. In addition, EA and Q-3-ME induced a cell cycle arrest in G0/G1 phase. These drugs did not affect normal cell viability. This data suggested that EA and Q-3-ME induce an increase in NO production that would lead to the cell cycle arrest and the activation of the intrinsic pathway of apoptosis. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Larrea/química
Linfoma/tratamento farmacológico
Extratos Vegetais/farmacologia
Polifenóis/farmacologia
Quercetina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Linfoma/patologia
Camundongos
Camundongos Endogâmicos C57BL
Óxido Nítrico/fisiologia
Quercetina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Polyphenols); 0 (quercetin 3-O-methyl ether); 31C4KY9ESH (Nitric Oxide); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160403
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5615


  8 / 107 MEDLINE  
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[PMID]:26916811
[Au] Autor:Sepúlveda L; de la Cruz R; Buenrostro JJ; Ascacio-Valdés JA; Aguilera-Carbó AF; Prado A; Rodríguez-Herrera R; Aguilar CN
[Ad] Endereço:Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, 25280 Saltillo, Coahuila, Mexico.
[Ti] Título:Effect of different polyphenol sources on the efficiency of ellagic acid release by Aspergillus niger.
[So] Source:Rev Argent Microbiol;48(1):71-7, 2016 Jan-Mar.
[Is] ISSN:0325-7541
[Cp] País de publicação:Argentina
[La] Idioma:eng
[Ab] Resumo:Fungal hydrolysis of ellagitannins produces hexahydroxydiphenic acid, which is considered an intermediate molecule in ellagic acid release. Ellagic acid has important and desirable beneficial health properties. The aim of this work was to identify the effect of different sources of ellagitannins on the efficiency of ellagic acid release by Aspergillus niger. Three strains of A. niger (GH1, PSH and HT4) were assessed for ellagic acid release from different polyphenol sources: cranberry, creosote bush, and pomegranate used as substrate. Polyurethane foam was used as support for solid-state culture in column reactors. Ellagitannase activity was measured for each of the treatments. Ellagic acid was quantified by high performance liquid chromatography. When pomegranate polyphenols were used, a maximum value of ellagic acid (350.21 mg/g) was reached with A. niger HT4 in solid-state culture. The highest amount of ellagitannase (5176.81 U/l) was obtained at 8h of culture when cranberry polyphenols and strain A. niger PSH were used. Results demonstrated the effect of different polyphenol sources and A. niger strains on ellagic acid release. It was observed that the best source for releasing ellagic acid was pomegranate polyphenols and A. niger HT4 strain, which has the ability to degrade these compounds for obtaining a potent bioactive molecule such as ellagic acid.
[Mh] Termos MeSH primário: Aspergillus niger/efeitos dos fármacos
Aspergillus niger/metabolismo
Ácido Elágico/metabolismo
Taninos Hidrolisáveis/farmacologia
Extratos Vegetais/farmacologia
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Larrea
Punicaceae
Vaccinium macrocarpon
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (Polyphenols); 19YRN3ZS9P (Ellagic Acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160328
[Lr] Data última revisão:
160328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE


  9 / 107 MEDLINE  
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[PMID]:26860525
[Au] Autor:Roskar I; Strukelj B; Lunder M
[Ad] Endereço:Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia.
[Ti] Título:Screening of Phenolic Compounds Reveals Inhibitory Activity of Nordihydroguaiaretic Acid Against Three Enzymes Involved in the Regulation of Blood Glucose Level.
[So] Source:Plant Foods Hum Nutr;71(1):88-9, 2016 Mar.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this work we have focused on the inhibition of three different enzymes with a role in postprandial glucose management: α-amylase, α-glucosidase and dipeptidyl peptidase 4. The assortment of 29 monomeric phenolic compounds was first screened at a single concentration. Next, the IC50 values of tested compounds were evaluated for compounds that considerably inhibited any of the enzymes. Nordihydroguaiaretic acid, a phenolic compound abundant in Creosote bush Larrea tridentata, possessed inhibitory activity for all tested enzymes. This in vitro mechanism of action supports traditional use of Creosote bush in diabetes treatment.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico
Hipoglicemiantes/farmacologia
Larrea/química
Masoprocol/farmacologia
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Glicemia/efeitos dos fármacos
Dipeptidil Peptidase 4/metabolismo
Inibidores da Dipeptidil Peptidase IV
Inibidores de Glicosídeo Hidrolases
Seres Humanos
Hipoglicemiantes/química
Hipoglicemiantes/isolamento & purificação
Masoprocol/química
Masoprocol/isolamento & purificação
Fenóis/química
Fenóis/isolamento & purificação
Período Pós-Prandial
alfa-Amilases/antagonistas & inibidores
alfa-Amilases/metabolismo
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Phenols); 7BO8G1BYQU (Masoprocol); EC 3.2.1.1 (alpha-Amylases); EC 3.2.1.20 (alpha-Glucosidases); EC 3.4.14.5 (Dipeptidyl Peptidase 4)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0530-0


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[PMID]:26763703
[Au] Autor:Kurnath P; Merz ND; Dearing MD
[Ad] Endereço:Department of Biology, University of Utah, Salt Lake City, UT 84112, USA patrice.kurnath@utah.edu.
[Ti] Título:Ambient temperature influences tolerance to plant secondary compounds in a mammalian herbivore.
[So] Source:Proc Biol Sci;283(1822), 2016 Jan 13.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Growing evidence suggests that plant secondary compounds (PSCs) ingested by mammals become more toxic at elevated ambient temperatures, a phenomenon known as temperature-dependent toxicity. We investigated temperature-dependent toxicity in the desert woodrat (Neotoma lepida), a herbivorous rodent that naturally encounters PSCs in creosote bush (Larrea tridentata), which is a major component of its diet. First, we determined the maximum dose of creosote resin ingested by woodrats at warm (28-29°C) or cool (21-22°C) temperatures. Second, we controlled the daily dose of creosote resin ingested at warm, cool and room (25°C) temperatures, and measured persistence in feeding trials. At the warm temperature, woodrats ingested significantly less creosote resin; their maximum dose was two-thirds that of animals at the cool temperature. Moreover, woodrats at warm and room temperatures could not persist on the same dose of creosote resin as woodrats at the cool temperature. Our findings demonstrate that warmer temperatures reduce PSC intake and tolerance in herbivorous rodents, highlighting the potentially adverse consequences of temperature-dependent toxicity. These results will advance the field of herbivore ecology and may hone predictions of mammalian responses to climate change.
[Mh] Termos MeSH primário: Herbivoria
Larrea/química
Resinas Vegetais/toxicidade
Sigmodontinae/fisiologia
Temperatura Ambiente
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Animais
Mudança Climática
Comportamento Alimentar
Sigmodontinae/metabolismo
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Resins, Plant); 0 (Toxins, Biological)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE



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